trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
as well as	1310
in patients with	917
the expression of	806
the presence of	750
the role of	667
the effect of	629
the development of	587
study was to	527
in order to	503
the aim of	497
in this study	493
the effects of	488
of this study	481
in response to	470
the present study	469
the number of	430
this study was	415
is associated with	407
in the presence	393
the use of	393
acute lung injury	388
been shown to	373
of patients with	357
one of the	353
cd t cells	352
involved in the	350
role in the	347
we found that	339
there was no	334
the treatment of	333
according to the	327
intensive care unit	323
to determine the	323
to evaluate the	319
aim of this	314
compared to the	313
to investigate the	308
an increase in	306
was used to	301
the production of	295
due to the	293
the activation of	291
has been shown	291
the pathogenesis of	288
the absence of	263
it has been	259
critically ill patients	258
as compared to	258
were treated with	258
in the present	256
the incidence of	253
a total of	251
to assess the	249
in the lung	247
was associated with	246
the regulation of	246
an important role	246
patients with severe	245
of the patients	240
in the lungs	239
results suggest that	235
there was a	232
associated with a	231
the level of	227
cells in the	226
activation of the	226
expression of the	224
the control group	222
respiratory distress syndrome	222
the induction of	218
a role in	216
tumor necrosis factor	215
in addition to	209
we investigated the	209
important role in	206
based on the	205
in the pathogenesis	205
a variety of	204
the levels of	203
the release of	201
in vitro and	199
in the absence	198
found to be	195
the ability of	193
the end of	192
the inflammatory response	189
in contrast to	188
acute respiratory distress	187
the formation of	186
data suggest that	186
to study the	182
in the control	181
well as the	178
contribute to the	178
have shown that	177
and in the	175
there is a	175
a number of	175
was observed in	174
for the treatment	174
to be a	174
increase in the	172
there were no	172
on the other	171
shown to be	170
resulted in a	169
the impact of	168
when compared to	167
of the study	166
the time of	165
were used to	164
the other hand	163
in the first	162
aim of the	161
we conclude that	160
and in vivo	160
in the regulation	159
central nervous system	158
cd and cd	158
changes in the	157
the activity of	157
vitro and in	156
the influence of	155
related to the	155
we show that	154
the cells were	152
results indicate that	152
a decrease in	151
in the icu	151
may contribute to	149
before and after	149
length of stay	149
is involved in	148
compared with the	147
the most common	146
play a role	146
analysis of the	145
admitted to the	145
in critically ill	145
in combination with	145
in both groups	145
the onset of	144
are involved in	144
was determined by	143
the results of	142
associated with the	142
in the treatment	141
a significant increase	140
the severity of	140
we hypothesized that	140
the purpose of	137
these results suggest	137
but not in	137
was measured by	137
compared to control	137
be involved in	137
at the time	136
the intensive care	135
levels of il	135
has been reported	135
has not been	134
observed in the	134
of the disease	133
in the development	132
no effect on	132
in comparison to	132
patients admitted to	132
was assessed by	132
significant increase in	132
the rate of	132
in terms of	131
suggest that the	130
the innate immune	130
for the first	129
is an important	129
the majority of	129
part of the	129
was found to	128
at the end	128
the function of	128
western blot analysis	127
by flow cytometry	127
were measured by	127
reactive oxygen species	127
is one of	126
high levels of	126
with respect to	126
as a result	125
in the brain	125
in the study	125
are associated with	124
of the present	124
effect on the	124
the immune system	124
seems to be	123
results show that	123
may be a	123
with or without	122
were obtained from	122
the risk of	122
the degree of	121
analysis was performed	121
the importance of	121
to the icu	121
to determine whether	120
than in the	120
smooth muscle cells	119
was performed using	119
this study we	119
used as a	119
can be used	118
during the first	118
is known to	118
known to be	118
the course of	117
play an important	117
have been shown	116
of the most	116
no significant difference	115
in a dose	115
the increase in	115
patients with acute	115
were found to	114
the hypothesis that	114
was to evaluate	114
the study was	114
significantly higher in	113
these data suggest	113
the context of	113
the first time	113
well as in	113
were able to	112
present study was	112
data indicate that	112
were included in	112
the immune response	111
the percentage of	111
tlr and tlr	111
of the immune	111
the amount of	110
levels in the	110
intensive care units	109
with septic shock	109
to examine the	109
between the two	108
study is to	108
with and without	108
in the context	108
at room temperature	108
the two groups	108
the administration of	108
patients with sepsis	107
associated with an	107
no significant differences	107
is characterized by	107
in the early	107
materials and methods	107
were subjected to	107
morbidity and mortality	106
this study is	106
multiple organ failure	106
included in the	106
in all patients	105
we have previously	105
differences in the	105
at the same	105
patients with a	105
associated with increased	104
plasma levels of	104
the central nervous	104
expression in the	103
there is no	103
due to a	103
compared to controls	103
the inhibition of	103
was used as	103
cells of the	102
was significantly higher	102
was to investigate	102
was found in	102
appears to be	102
responsible for the	102
we examined the	101
nitric oxide synthase	101
is essential for	101
were incubated with	101
the control of	101
induced lung injury	101
was defined as	101
to play a	101
we aimed to	100
apache ii score	100
role of the	100
end of the	99
were analyzed by	99
was used for	99
the generation of	99
be used to	99
had no effect	99
increased in the	99
in the human	99
was carried out	98
was to determine	98
a result of	98
obstetrics and gynecology	98
regulation of the	98
the need for	98
mouse model of	97
is mediated by	97
be due to	97
in the liver	97
blood samples were	97
the concentration of	97
increased expression of	96
be associated with	96
the diagnosis of	96
studies have shown	96
results showed that	95
and septic shock	95
in the lps	95
were determined by	95
of our study	95
findings suggest that	95
such as the	95
understanding of the	95
in women with	95
lung injury in	94
h after lps	94
are able to	94
were observed in	94
to identify the	94
we sought to	94
the mechanism of	93
by means of	93
serum levels of	93
is required for	93
the efficacy of	93
no difference in	93
a reduction in	93
are known to	93
the occurrence of	92
balb c mice	92
in intensive care	92
is known about	92
a model of	92
in vivo and	92
is able to	92
induced acute lung	91
little is known	91
showed that the	91
were isolated from	91
c bl mice	91
purpose of this	91
the involvement of	91
the interaction of	90
cd t cell	90
of the lung	90
the same time	90
the ability to	90
as shown in	89
we observed that	89
found that the	89
from patients with	89
gene expression in	88
t cells and	88
were used for	88
been reported to	88
depending on the	88
patients were included	88
the lack of	88
to be the	88
innate immune system	87
a role for	87
in our study	87
to test the	87
activity of the	87
of these patients	87
can lead to	87
the surface of	87
mrna and protein	87
plays an important	87
the patients with	86
a mouse model	86
innate immune response	86
may lead to	86
the relationship between	86
supported by the	85
found in the	85
most of the	85
was induced by	85
in the same	85
effects of the	85
innate and adaptive	85
the frequency of	85
an in vitro	85
as previously described	85
expression levels of	84
was no significant	84
the pathophysiology of	84
significant difference in	84
and activation of	84
were associated with	83
by western blot	83
in septic shock	83
a period of	83
significant differences in	82
shown in fig	82
chronic obstructive pulmonary	82
used in the	82
we hypothesize that	82
our results suggest	82
gd t cells	82
systemic inflammatory response	82
a and b	82
are expressed as	82
the management of	82
t cells in	81
is a major	81
we studied the	81
of the inflammatory	81
the duration of	81
did not differ	81
patients in the	81
may play a	81
the cell surface	81
was no difference	81
mean arterial pressure	81
present in the	80
higher in the	80
and h after	80
considered to be	80
for the development	80
show that the	80
was shown to	80
to the development	80
a critical role	80
the case of	80
the in vivo	80
were significantly higher	79
in the case	79
the fact that	79
a key role	79
was performed on	79
indicate that the	79
in the mouse	79
an increase of	79
inhibition of the	79
for patients with	79
to analyze the	78
the patients were	78
did not affect	78
a series of	78
the outcome of	78
in the group	78
obstructive pulmonary disease	78
was evaluated by	78
effect of the	77
increased levels of	77
it is not	77
were exposed to	77
was detected in	76
we have shown	76
with a mean	76
led to a	76
statistical analysis was	76
in relation to	76
the addition of	76
to compare the	76
in septic patients	76
in accordance with	76
the process of	75
of the human	75
the in vitro	75
followed by a	75
of septic shock	75
with regard to	75
these findings suggest	75
inflammatory response in	75
of nitric oxide	75
because of the	74
group of patients	74
of proinflammatory cytokines	74
of mechanical ventilation	74
expressed in the	74
to determine if	74
members of the	74
was performed in	74
the application of	74
is the most	74
in the expression	73
the basis of	73
stimulated with lps	73
is a common	73
the objective of	73
a group of	73
a combination of	73
have demonstrated that	73
the most important	73
and cd t	73
is the first	73
components of the	73
in these patients	73
significantly increased in	73
the molecular mechanisms	72
were divided into	72
response to lps	72
total of patients	72
in line with	72
of acute lung	72
be related to	72
blood mononuclear cells	72
mechanism by which	72
with severe sepsis	72
in which the	72
for min at	72
contributes to the	72
we observed a	71
detected in the	71
difference in the	71
to be involved	71
production of il	71
decrease in the	71
were purchased from	71
is thought to	71
samples were collected	71
in the blood	71
levels of the	71
cells were treated	71
between the groups	71
were detected in	70
peripheral blood mononuclear	70
at least one	70
data show that	70
a significant reduction	70
the lungs of	70
were found in	70
we performed a	70
we analyzed the	70
expression of il	70
levels were measured	70
were measured in	70
be used as	69
the result of	69
within the first	69
key role in	69
the identification of	69
of the innate	69
we showed that	69
of cd t	69
was significantly lower	68
the spinal cord	68
in comparison with	68
was significantly reduced	68
in a mouse	68
t cell activation	68
is due to	68
we found a	68
sepsis and septic	68
induced by lps	68
were used as	68
to reduce the	68
the secretion of	68
or absence of	68
in the patients	68
patients with septic	68
some of the	68
and in vitro	67
the first h	67
results demonstrate that	67
the plasma membrane	67
expression of cd	67
t cell responses	67
difference between the	67
of gene expression	67
oxidative stress and	67
was supported by	67
was added to	67
was able to	67
levels of tnf	67
aim of our	67
presence or absence	66
these results indicate	66
our results show	66
thought to be	66
we evaluated the	66
showed a significant	66
have been reported	66
for h at	66
in the number	66
the recruitment of	66
of patients were	65
of t cells	65
has been demonstrated	65
their ability to	65
of severe sepsis	65
member of the	65
vascular smooth muscle	65
in vitro studies	65
demonstrated that the	65
our study was	65
as compared with	65
of these cells	65
remains to be	65
were no significant	64
which may be	64
we demonstrate that	64
mrna expression of	64
in this model	64
higher levels of	64
h after the	64
the study period	64
lung injury and	64
this is the	64
none of the	64
in patients who	63
in the cns	63
been associated with	63
the association between	63
to elucidate the	63
is regulated by	63
for at least	63
effects on the	63
in endothelial cells	63
the changes in	63
critical role in	63
influenza a virus	63
the lps group	63
of the two	63
aim was to	63
is responsible for	63
did not change	63
compared to those	63
of inflammatory cytokines	62
the extent of	62
this work was	62
this effect was	62
in the rat	62
a significant decrease	62
activated protein kinase	62
as a consequence	62
activation of nf	62
our results indicate	62
area under the	62
we used a	62
significantly higher than	62
objective of this	61
approved by the	61
school of medicine	61
mechanism of action	61
was seen in	61
mean age of	61
that in the	61
is expressed in	61
to explore the	61
been shown that	61
isolated from the	61
been implicated in	61
in animal models	61
the first hours	61
in the intensive	61
significantly associated with	61
was to assess	61
was measured using	60
activity in the	60
could not be	60
to investigate whether	60
the analysis of	60
a crucial role	60
patients who were	60
patients with chronic	60
increased risk of	60
the combination of	60
the transcription factor	60
we were able	60
renal replacement therapy	60
was increased in	60
is based on	60
were admitted to	60
acute respiratory failure	60
acts as a	59
leading to the	59
for more than	59
was performed to	59
significantly lower in	59
were collected from	59
on the basis	59
we demonstrated that	59
innate immune responses	59
in case of	59
correlation between the	59
was higher in	59
inflammatory response and	59
which can be	59
in icu patients	59
were stained with	59
the acute phase	59
significantly reduced in	59
used to determine	59
evaluation of the	59
reduction in the	59
of the cell	58
in the central	58
required for the	58
significant decrease in	58
protective effect of	58
not associated with	58
acute renal failure	58
the animals were	58
the most frequent	58
added to the	58
were performed in	58
after lps injection	58
of the brain	58
this suggests that	58
response to the	58
was confirmed by	58
caused by the	58
mhc class ii	58
has been suggested	58
the contribution of	57
of reactive oxygen	57
the prevalence of	57
fold increase in	57
has also been	57
risk factor for	57
the progression of	57
in the adult	57
which is a	57
with lps and	57
as in the	57
derived from the	57
the mice were	57
have been described	57
in this group	57
was a significant	57
were stimulated with	57
implicated in the	57
significant reduction in	57
a consequence of	57
with severe hepatitis	57
maternal and fetal	57
inhibitory effect of	57
and can be	57
the site of	57
this is a	57
to improve the	57
cytokines such as	57
on the surface	57
in the serum	57
number of patients	57
did not show	57
acute kidney injury	57
data were analyzed	57
a major role	56
in peripheral blood	56
measured by elisa	56
consistent with the	56
the binding of	56
are presented as	56
our data suggest	56
as measured by	56
characterized by a	56
a concentration of	56
of the lps	56
shown that the	56
on the cell	56
cell proliferation and	56
immune response to	56
divided into two	56
severe sepsis and	56
at h after	56
mice treated with	56
patients treated with	56
regulatory t cells	56
not significantly different	56
the detection of	56
vivo and in	56
than that of	55
data demonstrate that	55
was performed by	55
and oxidative stress	55
control of the	55
was measured in	55
to the control	55
animal models of	55
were cultured in	55
in a significant	55
was obtained from	55
inducible nitric oxide	55
of the cells	55
all patients were	55
has been proposed	55
development of the	55
more likely to	55
the modulation of	55
the type of	55
and expression of	55
we tested the	55
were measured using	54
test was used	54
of lung injury	54
of critically ill	54
function of the	54
region of the	54
was significantly increased	54
to inhibit the	54
present study we	54
with an increased	54
injection of lps	54
into two groups	54
leads to a	54
correlated with the	54
admitted to our	54
in each group	54
cytokines and chemokines	54
the presence or	54
of the total	54
further studies are	54
the introduction of	54
and western blot	54
t cells were	54
have previously shown	54
was performed with	53
a reduction of	53
severity of the	53
of mg kg	53
seen in the	53
to that of	53
total rna was	53
used to assess	53
a pivotal role	53
vascular endothelial growth	53
known about the	53
in acute lung	53
used as an	53
determined by the	53
total number of	53
results of the	53
suggesting that the	53
to be associated	53
results in the	53
obtained from the	53
after lps challenge	53
are shown in	53
the current study	53
that of the	53
dependent on the	53
lower in the	53
as a potential	53
component of the	53
mode of action	53
in a model	52
the increase of	52
the mean age	52
were performed using	52
such as il	52
and protein expression	52
in both the	52
patients with cirrhosis	52
its role in	52
appear to be	52
protein expression in	52
experiments were performed	52
which leads to	52
we have recently	52
reported to be	52
endothelial growth factor	52
no differences in	52
the dorsal funiculus	52
in the pathophysiology	52
is a key	52
the existence of	52
of t cell	52
a dose of	52
on the expression	52
it was found	52
leads to the	52
bronchoalveolar lavage fluid	52
resulting in the	51
risk factors for	51
as assessed by	51
the interaction between	51
of inflammatory cells	51
the reduction of	51
of sepsis and	51
a marker of	51
stimulation of the	51
significant differences between	51
our understanding of	51
prior to the	51
have not been	51
an inhibitor of	51
differences between the	51
after lps administration	51
cells in vitro	51
mean age was	51
in of the	51
material and methods	51
mediated by the	51
significant difference between	51
in a murine	51
has to be	51
mhc class i	51
the mechanisms of	51
to have a	51
lead to a	51
mrna expression in	51
a member of	51
led to the	51
were used in	51
of cd and	51
well as a	50
the results showed	50
admission to the	50
inflammatory bowel disease	50
were carried out	50
impact on the	50
in the inflammatory	50
when compared with	50
used for the	50
is dependent on	50
by western blotting	50
were randomized to	50
risk of death	50
the nlrp inflammasome	50
a history of	50
we have developed	50
was determined using	50
quality of life	50
more than of	50
and that the	50
previously shown that	50
and function of	50
we did not	49
of intensive care	49
is caused by	49
the goal of	49
these data indicate	49
in recent years	49
essential for the	49
was present in	49
on the contrary	49
anp high pmn	49
sqad vite nps	49
due to its	49
have been identified	49
after h of	49
lead to the	49
likely to be	49
who did not	49
a central role	49
of the patient	49
is a potent	49
tumour necrosis factor	49
after lps stimulation	49
in group a	49
in a time	49
the patients who	48
the study of	48
suggests that the	48
any of the	48
it is also	48
diseases such as	48
response in the	48
revealed that the	48
rat model of	48
mice were treated	48
patients were admitted	48
insights into the	48
we have demonstrated	48
accordance with the	48
treated with lps	48
the proportion of	48
rna was extracted	48
transforming growth factor	48
for treatment of	48
the t cell	48
inflammatory cytokines and	48
all of the	48
to define the	48
investigate the role	48
the phosphorylation of	48
needs to be	48
we propose that	47
was found that	47
in this process	47
data are expressed	47
only in the	47
may be an	47
expressed as mean	47
plays a role	47
mrna expression was	47
course of the	47
was inhibited by	47
samples were obtained	47
a and il	47
and treatment of	47
its ability to	47
were higher in	47
for up to	47
higher than in	47
compared to non	47
after treatment with	47
is not known	47
was analyzed by	47
were significantly increased	47
of patients who	47
pivotal role in	47
with a high	47
we used the	47
care and use	47
results in a	47
resulting in a	47
in vitro model	47
in the following	47
expression of a	47
not affected by	47
as a model	47
of action of	47
and mg kg	47
significant increase of	46
in nod mice	46
a decrease of	46
were collected at	46
epithelial cells and	46
major role in	46
we compared the	46
pharmakologie und toxikologie	46
objective was to	46
previous studies have	46
male and female	46
specific cd t	46
are the most	46
kg body weight	46
based on a	46
in all the	46
appeared to be	46
with an increase	46
in all cases	46
ligation and puncture	46
during the study	46
which has been	46
mice compared to	46
mechanically ventilated patients	46
was higher than	46
in the last	46
which in turn	46
a range of	46
cause of death	46
our aim was	46
specific t cells	46
due to their	46
in the plasma	46
mechanisms involved in	46
and stored at	46
are needed to	46
the first days	46
may be involved	45
traumatic brain injury	45
this may be	45
the lung tissue	45
red blood cells	45
surfactant protein a	45
different types of	45
of inflammatory mediators	45
and may be	45
and treated with	45
and did not	45
genes involved in	45
in group b	45
were compared to	45
were collected and	45
has been associated	45
analysis showed that	45
of the anti	45
development of a	45
murine model of	45
of adhesion molecules	45
was not affected	45
of patients admitted	45
the quality of	45
be responsible for	45
levels were significantly	45
admitted to icu	45
was designed to	45
the mortality rate	45
similar to that	45
the emergency department	45
were detected by	45
in this context	45
that can be	44
central role in	44
and has been	44
such as tnf	44
to understand the	44
injury in mice	44
mortality rate was	44
to describe the	44
is consistent with	44
of mice with	44
wide range of	44
of icu stay	44
and of the	44
cells were cultured	44
is supported by	44
in the induction	44
the response to	44
in these cells	44
the potential to	44
their role in	44
was to compare	44
of the same	44
of the protein	44
cecal ligation and	44
the initiation of	44
and after the	44
inflammatory response syndrome	44
after stimulation with	44
the loss of	44
oxidative stress in	44
the accumulation of	44
out of the	44
and on the	44
compared to wt	43
microvascular endothelial cells	43
prospective observational study	43
at least in	43
a murine model	43
we conducted a	43
of the il	43
were compared with	43
are essential for	43
the association of	43
of cytokines and	43
immune response in	43
multiple organ dysfunction	43
similar to the	43
of the blood	43
highly expressed in	43
induced by the	43
our results demonstrate	43
be explained by	43
in the current	43
lung tissues were	43
expression in human	43
the possibility of	43
due to an	43
patients suffering from	43
and mortality in	43
and intensive care	43
p and p	43
a wide range	43
and it is	43
the total number	42
important for the	42
septic shock and	42
higher in patients	42
there are no	42
linked immunosorbent assay	42
vg vd t	42
be attributed to	42
patients who died	42
has been described	42
is not clear	42
induced activation of	42
years of age	42
compared to wild	42
but did not	42
the university of	42
treatment with the	42
the pattern of	42
presence of a	42
patients had a	42
at the level	42
was induced in	42
reduction of the	42
the action of	42
in association with	42
and hours after	42
production of tnf	42
study was designed	42
severity of illness	42
is important to	42
was found between	42
with a higher	42
immune response and	42
it is possible	42
in the activation	42
lung injury by	42
data not shown	42
significant changes in	42
analysis of variance	42
is critical for	41
were determined using	41
immune responses in	41
conclude that the	41
days after the	41
it can be	41
in t cells	41
to characterize the	41
that there is	41
carried out in	41
the maintenance of	41
in the course	41
change in the	41
in the acute	41
logistic regression analysis	41
dose of lps	41
the inhibitory effect	41
was assessed using	41
in the fetal	41
as determined by	41
samples were taken	41
the capacity of	41
has been implicated	41
the effectiveness of	41
the concentrations of	41
act as a	41
the possibility that	41
endothelial cells and	41
cytokine production in	41
dose of mg	41
we investigated whether	41
insight into the	41
in a variety	41
concentrations in the	41
compared with control	41
measured by the	41
elevated levels of	41
to contribute to	41
have to be	41
and endothelial cells	41
as part of	41
serve as a	41
low levels of	41
we are currently	41
a lack of	41
c bl j	41
been identified as	41
the potential of	41
demonstrate that the	41
studies showed that	41
was not significantly	41
will be presented	40
cells from the	40
with a significant	40
were no differences	40
was similar in	40
binding to the	40
necrosis factor alpha	40
shown in table	40
half of the	40
each of the	40
cells were incubated	40
or in combination	40
antigen presenting cells	40
should be considered	40
the area under	40
but not the	40
our data indicate	40
a family of	40
the gene expression	40
the expression and	40
the day of	40
investigated the effects	40
in the heart	40
at a dose	40
mechanisms by which	40
the prevention of	40
a significant difference	40
were present in	40
the magnitude of	40
cells treated with	40
the ratio of	40
to this end	40
mobility group box	40
study was conducted	40
of oxidative stress	40
the lungs and	40
by using a	40
the growth of	40
over a period	40
t cells from	40
patients who had	40
an increased risk	40
investigated the effect	40
patients admitted in	40
in the spinal	40
it is a	40
need to be	40
the bone marrow	40
the kinetics of	39
but not by	39
was reduced by	39
was extracted from	39
wild type mice	39
were not significantly	39
is believed to	39
may represent a	39
of the central	39
we have also	39
in a concentration	39
acute liver failure	39
for h and	39
crucial role in	39
and release of	39
better understanding of	39
may be due	39
are expressed in	39
and adaptive immunity	39
been found to	39
a subset of	39
were obtained at	39
use of a	39
a and sp	39
of acute respiratory	39
of the major	39
could be used	39
the authors declare	39
all the patients	39
disruption of the	39
the recognition of	39
gene expression of	39
to be more	39
these results demonstrate	39
tlr expression in	39
did not have	39
at risk for	39
in the two	39
the accuracy of	39
adaptive immune responses	39
significantly reduced the	39
the decrease in	39
of these two	39
and at the	39
the gastrointestinal tract	39
molecular mechanisms of	39
work was supported	39
will be discussed	38
is a novel	38
of endothelial cells	38
polymerase chain reaction	38
cells and the	38
that it is	38
to respond to	38
role in regulating	38
in the hippocampus	38
was accompanied by	38
can be found	38
intestinal epithelial cells	38
accompanied by a	38
and secretion of	38
g for min	38
as described previously	38
mutations in the	38
expression of tlr	38
cm h o	38
may result in	38
differentially expressed genes	38
that the expression	38
analyses were performed	38
characterization of the	38
in the production	38
by using the	38
but it is	38
male wistar rats	38
in the process	38
was significantly decreased	38
activated protein c	38
the range of	38
class i molecules	38
depends on the	38
of up to	38
in our icu	38
included in this	38
challenged with lps	38
the time course	38
in regulation of	38
data were collected	38
protective effects of	38
is the main	38
of neutrophils in	38
is related to	38
the mrna expression	38
in lung tissue	38
the cause of	38
of the lungs	38
tnf and il	38
were evaluated by	38
a in the	38
significant differences were	37
test the hypothesis	37
t cell receptor	37
up to days	37
reduced in the	37
and severity of	37
with the development	37
data are presented	37
it is important	37
did not induce	37
of the liver	37
in the cell	37
h and h	37
is accompanied by	37
in critical care	37
at risk of	37
in the literature	37
were pretreated with	37
is the major	37
we suggest that	37
of death in	37
identified as a	37
flow cytometry and	37
large number of	37
our data show	37
was also observed	37
to be an	37
participate in the	37
it may be	37
disseminated intravascular coagulation	37
mrna levels were	37
evaluate the effect	37
patients who underwent	37
is induced by	37
patients were divided	37
a set of	37
these data demonstrate	37
we determined the	37
the mechanism by	37
and the subsequent	37
s a and	37
may have a	37
mrna levels of	37
from january to	37
different time points	37
study showed that	37
was lower in	37
in all groups	37
inhibitory effect on	37
of tlr and	37
decreased in the	37
secretion of il	37
induction of the	37
the expression levels	37
presence of the	37
in of patients	37
to test this	37
gene expression was	37
seem to be	36
to the intensive	36
and the number	36
the evaluation of	36
measured in the	36
our findings suggest	36
for this purpose	36
the response of	36
were analyzed for	36
the length of	36
b and c	36
real time pcr	36
of inflammation and	36
inflammatory effects of	36
intercellular adhesion molecule	36
production of the	36
between january and	36
were compared using	36
have been used	36
in a rat	36
is activated by	36
in severe hepatitis	36
in the past	36
as indicated by	36
has been identified	36
inflammatory response to	36
the apache ii	36
and compared to	36
b cells and	36
been suggested to	36
injected into the	36
it is likely	36
decrease of the	36
in an in	36
study was performed	36
by an increase	36
significantly increased the	36
we aim to	36
in the kidney	36
a rat model	36
the value of	36
were analyzed using	36
associated molecular patterns	36
to the cell	36
women with a	36
sought to determine	36
the downregulation of	36
is considered to	36
as an important	36
we developed a	36
the last years	36
gene expression and	36
might be a	36
protein expression of	36
increase of the	36
has been found	36
defi cient mice	36
with the control	36
there is an	36
defined as a	36
astrocytes and microglia	36
the survival of	36
signal transduction pathways	36
production of inflammatory	36
was applied to	36
the correlation between	36
been reported that	36
and the expression	36
are required to	36
were significantly lower	36
was identified as	36
of tumor necrosis	36
time course of	35
the critically ill	35
which could be	35
located in the	35
alone or in	35
many of the	35
two groups of	35
the menstrual cycle	35
negative regulator of	35
were quantified by	35
cell death in	35
in the body	35
up to h	35
is present in	35
of innate immunity	35
investigate the effect	35
the uptake of	35
in mice and	35
administration of lps	35
the acute respiratory	35
of the pulmonary	35
data was collected	35
in vitro experiments	35
the nature of	35
in our previous	35
no correlation between	35
in the spleen	35
university medical center	35
vascular endothelial cells	35
t cell response	35
to the nucleus	35
that inhibition of	35
expression of genes	35
may be useful	35
of lps and	35
a role of	35
and inhibition of	35
the differentiation of	35
the protective effect	35
intravenous injection of	35
we could show	35
blood pressure and	35
in vivo studies	35
a mean age	35
arterial blood pressure	35
to develop a	35
leading to a	35
formation of the	35
an inflammatory response	35
the lung tissues	35
interferon regulatory factor	35
characterized by the	35
the cell membrane	35
of the receptor	35
are responsible for	35
mouse and human	35
inflammation in the	35
was followed by	35
to increase the	35
for the diagnosis	35
with the same	35
phase of the	35
of in vitro	35
sensitivity and specificity	35
of the tlr	35
t cell proliferation	35
did not alter	35
significantly lower than	35
was considered significant	35
were similar in	35
we have investigated	35
after the onset	35
mortality in the	35
the most potent	34
it is known	34
linked to the	34
of the pro	34
were assessed by	34
not able to	34
as shown by	34
hours after lps	34
the first day	34
the samples were	34
inflammatory cytokines in	34
be caused by	34
of all patients	34
analysis revealed that	34
in spite of	34
no differences were	34
important in the	34
use of the	34
recruitment to the	34
induced expression of	34
may not be	34
performed using the	34
contrast to the	34
a statistically significant	34
that activation of	34
involved in this	34
pcr was performed	34
stay in icu	34
the proliferation of	34
factor in the	34
within hours of	34
response to a	34
and patients with	34
patients at risk	34
in the placenta	34
stimulation with lps	34
findings indicate that	34
was quantified by	34
central venous pressure	34
the distribution of	34
were significantly reduced	34
in the management	34
to clarify the	34
groups of patients	34
the lungs were	34
in wt mice	34
of the host	34
an in vivo	34
of the p	34
major cause of	34
the group of	34
the systemic circulation	34
assessment of the	34
cytokines in the	34
compared to normal	34
mg kg day	34
is not a	34
in a large	34
icu and hospital	34
was used in	34
focused on the	34
be considered as	34
blood was collected	34
we measured the	34
mesenchymal stem cells	34
of the respiratory	34
a prospective study	34
cells in a	34
level of the	34
believed to be	34
we have found	34
we have identified	34
in the future	34
expression of pro	34
to confirm the	34
neutrophils in the	34
the suppression of	33
was detected by	33
in a prospective	33
at a concentration	33
to interact with	33
the data were	33
is produced by	33
in the formation	33
b and il	33
acute and chronic	33
high concentrations of	33
of the different	33
in mice with	33
were added to	33
leading cause of	33
to those of	33
order to determine	33
respiratory syncytial virus	33
with a history	33
the form of	33
was expressed in	33
of the main	33
as evidenced by	33
play a key	33
patients with liver	33
are thought to	33
it was shown	33
transient receptor potential	33
in the non	33
t cells are	33
used in this	33
concentrations of the	33
to the pathogenesis	33
with acute respiratory	33
systemic lupus erythematosus	33
retrospective cohort study	33
the relevance of	33
was the most	33
ill patients with	33
for statistical analysis	33
a better understanding	33
lung inflammation and	33
in the balf	33
in gene expression	33
at different time	33
exposure to lps	33
women with pcos	33
in the immune	33
animals treated with	33
a large number	33
protein expression was	33
as described in	33
play a critical	33
the start of	33
in the peripheral	33
were determined in	33
has shown that	33
not in the	33
in the skin	33
were shown to	33
both in vitro	33
we also found	33
adaptive immune response	33
plasma concentrations of	33
the small intestine	33
with sepsis and	33
group compared to	33
by treatment with	33
effects in the	33
has been observed	33
of expression of	33
is important for	33
the systemic inflammatory	32
to quantify the	32
determine the effect	32
of the endothelial	32
intraperitoneal injection of	32
indicating that the	32
considered as a	32
of the cellular	32
in these mice	32
injury induced by	32
our previous study	32
have been found	32
was conducted in	32
university school of	32
to patients with	32
and the presence	32
astrocytes in the	32
was based on	32
addition to the	32
a mixture of	32
are likely to	32
important role of	32
resulted in an	32
able to induce	32
was not associated	32
of heme oxygenase	32
could be a	32
during the last	32
after the last	32
study of the	32
lower than in	32
shown in the	32
a significantly higher	32
to the activation	32
an animal model	32
administration of the	32
by measuring the	32
higher than that	32
not differ between	32
months of age	32
indicated that the	32
associated with higher	32
based on these	32
not affect the	32
of the mouse	32
of the intestinal	32
animals were sacrificed	32
is likely to	32
to a significant	32
to be elucidated	32
first time that	32
of cd b	32
can also be	32
of at least	32
to an increase	32
to the lungs	32
be able to	32
hours after the	32
or septic shock	32
structure of the	32
in the second	32
was collected from	32
in patients admitted	32
assessed by the	32
our results showed	32
are present in	32
and in patients	32
were performed by	32
resulted in the	32
produced by the	32
have also been	32
be used for	32
the assessment of	32
of a single	32
the icu and	32
be mediated by	32
t cells to	32
lung epithelial cells	31
result of the	31
no significant changes	31
may provide a	31
patients and methods	31
be useful in	31
the evolution of	31
results were obtained	31
recent studies have	31
in patients undergoing	31
of icu admission	31
were identified by	31
a significant correlation	31
inhibitory effects of	31
production in the	31
treatment of the	31
of the drug	31
not statistically significant	31
our objective was	31
in conjunction with	31
delta t cells	31
in severe sepsis	31
thermo fisher scientific	31
in the other	31
liver and spleen	31
and days after	31
treated with a	31
shown to play	31
bone marrow cells	31
was increased by	31
may also be	31
a and c	31
alterations in the	31
production of pro	31
is increased in	31
was also found	31
be an important	31
of type diabetes	31
properties of the	31
that have been	31
low molecular weight	31
we assessed the	31
a change in	31
is necessary for	31
human endothelial cells	31
result in a	31
effect of a	31
was approved by	31
have found that	31
and respiratory syndrome	31
were enrolled in	31
of stay in	31
as a marker	31
sod g a	31
regions of the	31
length of icu	31
factors such as	31
is likely that	31
in the intestine	31
there was an	31
these results show	31
the synthesis of	31
the sections were	31
evidence suggests that	31
the reduction in	31
been reported in	31
animal model of	31
to analyse the	31
inflammatory responses in	31
the implementation of	31
of patients and	31
the measurement of	31
are required for	31
human umbilical vein	30
incubated for h	30
to detect the	30
and flow cytometry	30
mortality in patients	30
cytokine production by	30
of s a	30
to be important	30
caused by a	30
were studied in	30
males and females	30
systolic blood pressure	30
body mass index	30
surfactant protein d	30
defined as the	30
the patient was	30
compared to lps	30
as a novel	30
of pulmonary surfactant	30
and incubated with	30
significantly different between	30
portion of the	30
cxcr and cxcr	30
mechanism of the	30
the survival rate	30
not due to	30
to the same	30
did not significantly	30
responses in the	30
proved to be	30
acute lung inflammation	30
septic shock patients	30
a protective role	30
even in the	30
shown to have	30
play a major	30
the early phase	30
early phase of	30
ischemia reperfusion injury	30
was lower than	30
the mechanisms underlying	30
as a control	30
is difficult to	30
followed by the	30
be used in	30
was reduced in	30
results of this	30
the upregulation of	30
coronary artery bypass	30
surface expression of	30
diagnosis and treatment	30
a dose dependent	30
a panel of	30
the determination of	30
and stained with	30
expression pattern of	30
is also a	30
to measure the	30
in the postoperative	30
whitney u test	30
to the lung	30
supported by nih	30
probably due to	30
to play an	30
and b cells	30
h at room	30
measured using a	30
led to an	30
middle cerebral artery	30
of the following	30
and multiple organ	30
potential role of	30
was due to	30
to activation of	30
here we show	30
that has been	30
and use of	30
also known as	30
the source of	30
these results are	30
in vitro assays	30
has been used	30
by the presence	30
application of the	30
and is associated	30
pattern recognition receptors	30
served as controls	30
r d systems	30
of apoptotic cells	30
relationship between the	30
we could not	30
may be associated	30
information about the	30
to a lesser	30
acute myocardial infarction	30
study aimed to	30
by the use	30
differences were found	30
icu length of	30
of the experiment	29
mice were sacrificed	29
organ dysfunction syndrome	29
importance of the	29
septic shock in	29
similar results were	29
all patients admitted	29
be found in	29
hematoxylin and eosin	29
of the spleen	29
of patients had	29
were performed on	29
of the cd	29
as early as	29
were increased in	29
is required to	29
and protein levels	29
hepatitis c virus	29
cells transfected with	29
protein kinase c	29
role of this	29
mg kg body	29
organ failure and	29
in this regard	29
a positive correlation	29
model of acute	29
embedded in paraffin	29
presented as mean	29
to bind to	29
in the developing	29
methods and results	29
a previous study	29
rna was isolated	29
by lps in	29
the results are	29
investigate the effects	29
also found that	29
the change in	29
similar in both	29
may be the	29
significantly decreased in	29
lead to an	29
but also in	29
effects of a	29
systemic vascular resistance	29
in t cell	29
as described above	29
higher incidence of	29
similar to those	29
in trauma patients	29
patients with the	29
was purchased from	29
the appearance of	29
and cytokine production	29
in of cases	29
after the first	29
to establish the	29
could show that	29
we have used	29
the supernatant was	29
from the same	29
important roles in	29
treated with the	29
cells as well	29
in in vitro	29
majority of patients	29
of a novel	29
was assessed in	29
injury in the	29
as a key	29
all patients with	29
in the initial	29
mechanical ventilation and	29
surface of the	29
damage in the	29
studies are needed	29
of cells with	29
of heart failure	29
cells were then	29
which is the	29
were analyzed with	29
the results show	29
the extracellular matrix	29
response of the	29
extracted from the	29
to the lps	29
higher than the	29
is used to	29
hla class i	29
the characteristics of	29
cells were stimulated	29
in some cases	28
of the first	28
the endoplasmic reticulum	28
capacity of the	28
safety and efficacy	28
are important for	28
of the enzyme	28
for the detection	28
marked increase in	28
ttp ko mice	28
independent of the	28
of immune cells	28
to be determined	28
in presence of	28
the liver and	28
of the clinical	28
study we investigated	28
been suggested that	28
fetal bovine serum	28
of this work	28
in the dorsal	28
no statistically significant	28
in any of	28
was measured at	28
may be related	28
and nitric oxide	28
beneficial effects of	28
to estimate the	28
is a complex	28
and subjected to	28
of innate immune	28
after days of	28
human peripheral blood	28
wide variety of	28
in children with	28
one of these	28
contributing to the	28
well as to	28
the th day	28
the migration of	28
production of cytokines	28
the adaptive immune	28
differences between groups	28
and is a	28
play a pivotal	28
delivery to the	28
was to examine	28
no difference between	28
pulmonary artery catheter	28
in control group	28
evidence for a	28
induction of apoptosis	28
could be detected	28
impact of the	28
of the right	28
the beginning of	28
the age of	28
diagnosis of sepsis	28
adult respiratory distress	28
as a negative	28
the pi k	28
pulmonary artery pressure	28
in this case	28
in agreement with	28
role for the	28
downregulation of palm	28
group a and	28
compared with those	28
were analysed by	28
to better understand	28
for the study	28
duration of mechanical	28
and to a	28
of women with	28
on the first	28
in bronchoalveolar lavage	28
are capable of	28
the peripheral blood	28
described in the	28
early stage of	28
provide evidence that	28
the period of	28
to validate the	28
umbilical vein endothelial	28
a risk factor	28
vd t cells	28
were measured at	28
nature of the	28
function in the	28
expressed as the	28
the difference between	28
pcr and western	28
were harvested and	28
of this disease	28
and an increase	28
modulation of the	28
were defined as	28
of the nlrp	28
is an essential	28
the present work	28
the protein expression	28
high level of	28
differences were observed	28
the outer membrane	28
in the host	28
also involved in	28
changes of the	28
to control the	28
for each patient	28
is a critical	28
in the culture	28
bl j mice	28
investigated the role	28
this effect is	28
plays a key	28
plays a critical	28
a diagnosis of	28
were more likely	28
number of cells	28
a trend towards	28
after cardiac surgery	28
p x r	27
to our icu	27
of multiple organ	27
data on the	27
study demonstrates that	27
all patients received	27
we generated a	27
were seen in	27
concentration of the	27
oral administration of	27
arterial blood gases	27
activation in the	27
inflammatory cytokine production	27
to our knowledge	27
we speculate that	27
has been recently	27
necessary for the	27
no evidence of	27
the h r	27
flow cytometric analysis	27
the performance of	27
d and d	27
admitted to a	27
response to infection	27
of the three	27
nuclear translocation of	27
were isolated and	27
did not reach	27
severe head injury	27
the significance of	27
were fixed in	27
majority of the	27
the disease is	27
expression of these	27
was significantly associated	27
an essential role	27
have investigated the	27
efficacy of the	27
lps in the	27
the capacity to	27
sepsis or septic	27
was collected and	27
and with the	27
may be of	27
used to evaluate	27
been proposed to	27
of critical care	27
of the femoral	27
age of years	27
adult patients with	27
effector t cells	27
the patients had	27
and development of	27
and dendritic cells	27
studies have demonstrated	27
in both cell	27
were expressed as	27
study shows that	27
was to identify	27
results indicated that	27
used to compare	27
in c bl	27
resulted in increased	27
the culture medium	27
bovine serum albumin	27
and cd cd	27
analysis was used	27
vein endothelial cells	27
and length of	27
apache ii and	27
an average of	27
significant reduction of	27
in a number	27
hospital cardiac arrest	27
to induce a	27
studies suggest that	27
th and th	27
conflict of interest	27
in the pulmonary	27
of the skin	27
cytokine production and	27
in lung tissues	27
were incubated for	27
cells to the	27
knowledge of the	27
stages of the	27
work was to	27
a control group	27
of sepsis in	27
protective role of	27
negative predictive value	27
respect to the	27
in the form	27
two groups were	27
the united states	27
of group a	27
a measure of	27
is to evaluate	27
are presented in	27
in the supernatant	27
was shown that	27
correlation was found	27
the stimulation of	27
arterial blood gas	27
and for the	27
high mobility group	27
glasgow coma scale	27
have been implicated	27
has recently been	27
be a promising	27
order to identify	27
to explain the	27
of patients in	27
the three groups	27
of the control	27
leads to an	27
the lung and	27
is known that	27
each time point	27
was no correlation	27
as one of	27
was isolated from	27
herpes simplex virus	27
to be used	27
considered statistically significant	27
to participate in	27
day after the	27
c mice were	27
of them were	27
phosphorylation of the	27
statistically significant differences	27
protein in the	27
proteins in the	27
it is unclear	27
have developed a	27
treatment of acute	26
under the control	26
plays a central	26
mice were injected	26
especially in the	26
purpose of the	26
one or more	26
characteristics of the	26
referred to as	26
of laboratory animals	26
in a similar	26
and analyzed by	26
carried out by	26
be a useful	26
to evaluate whether	26
after exposure to	26
of tumor cells	26
as soon as	26
the inflammatory process	26
comparison to the	26
parts of the	26
patients were studied	26
day of gestation	26
proteins involved in	26
the decrease of	26
for the induction	26
a prospective observational	26
cultured in the	26
mechanisms underlying the	26
an association between	26
the setting of	26
not only in	26
the study group	26
the finding that	26
did not receive	26
of escherichia coli	26
cells were isolated	26
significant change in	26
upon stimulation with	26
by inhibition of	26
as demonstrated by	26
of more than	26
is possible that	26
in out of	26
are consistent with	26
fetal growth restriction	26
large amounts of	26
endothelial cells in	26
we set out	26
was calculated as	26
specific t cell	26
induced increase in	26
that may be	26
the underlying mechanisms	26
in cases of	26
t cells was	26
in hek cells	26
had a higher	26
the sensitivity of	26
at the cell	26
wt and vim	26
of genes involved	26
of the body	26
be important in	26
regardless of the	26
were collected for	26
anova followed by	26
increased production of	26
and apache ii	26
not yet been	26
to wild type	26
and to determine	26
were characterized by	26
is well known	26
of the gene	26
for a period	26
are characterized by	26
the development and	26
were performed to	26
patients who developed	26
of cell death	26
the concept that	26
of transcription factors	26
patients with and	26
with a median	26
were seeded in	26
divided into groups	26
may help to	26
severe acute respiratory	26
animal care and	26
in human myometrium	26
and adaptive immune	26
no change in	26
least in part	26
were taken from	26
period of time	26
regulated by the	26
was determined in	26
of the coagulation	26
of a variety	26
binds to the	26
several studies have	26
used to identify	26
in those with	26
mechanisms of the	26
using flow cytometry	26
applied to the	26
and s a	26
the complement system	26
pulmonary surfactant protein	26
at day after	26
the peak of	26
in the emergency	26
also in the	26
in some patients	26
be one of	26
and use committee	26
santa cruz biotechnology	26
outcome of patients	26
line with the	26
mortality rate of	26
is a promising	26
observed in patients	26
microglia and astrocytes	26
was not observed	26
and found that	26
were significantly decreased	26
g a mice	26
of body weight	26
more than one	26
different cell types	25
and loss of	25
is the only	25
has previously been	25
in models of	25
of the other	25
of the fetal	25
three independent experiments	25
not observed in	25
treatment of sepsis	25
a wide variety	25
the effect on	25
different stages of	25
lung tissue was	25
were placed in	25
an index of	25
release of pro	25
icu stay and	25
compared to a	25
tested the hypothesis	25
of the acute	25
pi k akt	25
in mechanically ventilated	25
and tumor necrosis	25
a and a	25
in the right	25
immune responses and	25
on the day	25
over the last	25
in vitro in	25
patients with an	25
provided by the	25
the dose of	25