quadgram

This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

quadgram frequency
in the presence of332
of this study was326
this study was to314
the aim of this288
aim of this study246
has been shown to212
in the present study210
an important role in195
in the pathogenesis of194
in the absence of179
acute respiratory distress syndrome178
as well as the177
for the treatment of163
on the other hand162
in the regulation of155
in vitro and in149
vitro and in vivo137
play a role in134
the aim of the128
at the time of125
in the treatment of125
at the end of122
these results suggest that121
in the development of118
in this study we117
in critically ill patients116
have been shown to116
play an important role114
as well as in113
is one of the112
been shown to be108
the present study was108
in the context of107
for the first time106
of the present study104
the central nervous system103
a significant increase in101
in the control group99
these data suggest that98
in patients with severe97
the intensive care unit94
study was to evaluate94
one of the most92
induced acute lung injury91
the purpose of this87
the expression of the86
of this study is86
the end of the86
there was no significant84
plays an important role84
was associated with a84
had no effect on81
purpose of this study80
aim of the present80
as a result of80
was found to be79
to the development of78
at the same time78
there was no difference78
chronic obstructive pulmonary disease78
for the development of76
studies have shown that76
present study was to76
a role in the76
study was to investigate76
the innate immune system75
important role in the75
admitted to the icu74
little is known about74
our results suggest that73
this study is to73
in the case of72
study was to determine72
was to evaluate the72
was to investigate the70
were found to be68
sepsis and septic shock68
a key role in68
to be involved in67
a total of patients67
presence or absence of65
patients with septic shock64
aim of the study64
peripheral blood mononuclear cells64
between the two groups64
is involved in the64
is associated with a63
may contribute to the63
no significant difference in63
the aim of our63
it has been shown62
of acute lung injury62
cells were treated with62
there were no significant62
of the study was62
of the innate immune62
in the number of61
we were able to60
a critical role in60
a mouse model of60
in the expression of60
in a mouse model60
these results indicate that59
in the intensive care59
role in the pathogenesis59
were included in the59
cd and cd t59
on the basis of59
involved in the regulation59
as shown in fig58
these findings suggest that58
was no significant difference58
in the lungs of58
the study was to58
was no difference in57
our results show that57
we have shown that57
patients admitted to the56
patients with severe hepatitis56
of our study was56
was to determine the56
has been reported to55
there was a significant55
on the surface of55
we found that the55
the role of the55
the objective of this55
are involved in the55
patients with severe sepsis54
aim of our study54
analysis was performed using54
an increase in the53
we have previously shown53
was used as a53
included in the study53
in response to lps53
be involved in the53
the presence or absence53
our data suggest that53
our results indicate that52
objective of this study52
vascular endothelial growth factor52
in vivo and in52
in patients with sepsis52
the present study we52
our study was to51
was significantly higher in51
is known about the51
as well as a50
in the central nervous50
and cd t cells50
statistical analysis was performed50
of reactive oxygen species50
to be associated with50
in the pathophysiology of50
of the immune system50
can be used to49
inducible nitric oxide synthase49
on the expression of48
has been shown that48
the innate immune response48
investigate the role of47
were significantly higher in47
it was found that47
this is the first46
a pivotal role in46
no significant differences in46
in a model of45
in accordance with the45
in acute lung injury45
these data indicate that45
a significant reduction in45
have previously shown that45
acute lung injury in45
plays a role in44
vivo and in vitro44
was observed in the44
data are expressed as44
results suggest that the44
our aim was to44
in the presence or43
a major role in43
in patients with acute43
vascular smooth muscle cells43
of cd t cells43
the regulation of the43
cecal ligation and puncture42
in patients with septic42
at the level of42
of critically ill patients42
of the immune response42
a member of the42
a significant decrease in42
associated with an increased42
a central role in41
of the inflammatory response41
divided into two groups41
in intensive care units41
severe sepsis and septic41
study was to assess41
patients were included in41
may play a role41
were no significant differences41
in a variety of41
the results showed that41
it has been reported40
resulted in a significant40
a wide range of40
over a period of40
investigated the effect of40
the total number of40
the presence of a40
to investigate the role40
is thought to be40
has been associated with40
lung injury in mice39
as a consequence of39
was to assess the39
with an increase in39
as compared to the38
is known to be38
on the cell surface38
in patients with cirrhosis38
there were no differences38
during the study period38
in the control of38
investigated the effects of38
may be due to38
to play a role38
the severity of the38
in the spinal cord37
no effect on the37
was significantly lower in37
the effect of the37
work was supported by37
may be involved in37
the area under the37
in the induction of37
the activation of the37
in the course of37
a crucial role in37
data are presented as37
in the production of36
a decrease in the36
the expression levels of36
the development of the36
is associated with an36
with the development of36
the mechanism by which36
the results of the35
the activity of the35
to the intensive care35
the acute respiratory distress35
are expressed as mean35
evaluate the effect of35
we conclude that the35
of tumor necrosis factor35
study was designed to35
test the hypothesis that35
systemic inflammatory response syndrome35
a murine model of35
by western blot analysis34
the inhibitory effect of34
it is important to34
we have demonstrated that34
be due to the34
at a dose of34
in the lps group34
before and after the34
to test the hypothesis34
after the onset of34
innate and adaptive immunity34
in the management of33
and the number of33
the effects of the33
has been reported that33
can be used as33
in contrast to the33
in order to determine33
play a key role33
is associated with increased33
role in the development33
of patients with severe33
tumor necrosis factor alpha33
blood samples were collected33
this work was supported33
with a mean age32
the course of the32
the first time that32
a significant increase of32
significantly higher in the32
in the activation of32
admission to the icu32
a better understanding of32
the protective effect of32
specific cd t cells32
investigate the effect of32
h after lps challenge32
study was to compare32
the presence of the32
we investigated the effects32
when compared to the32
to evaluate the effect32
acute lung injury and32
has been implicated in32
did not differ between31
university school of medicine31
in a murine model31
the time course of31
it is likely that31
a rat model of31
t cells in the31
was not associated with31
of patients admitted to31
with a history of31
by an increase in31
to the pathogenesis of31
our results demonstrate that31
of the central nervous31
at a concentration of31
play a critical role31
that the expression of31
and western blot analysis31
were admitted to the31
was used to determine31
in patients with chronic31
our objective was to31
well as in the30
of cd and cd30
h at room temperature30
a mean age of30
is essential for the30
critically ill patients with30
in the first h30
and the presence of30
mice were treated with30
role in the regulation30
the use of a30
were divided into two30
the development of a30
compared to the control30
determine the effect of30
our data show that30
by the use of30
icu length of stay30
by the presence of29
was significantly higher than29
been implicated in the29
both in vitro and29
mrna and protein expression29
been reported to be29
been shown to play29
at h after lps29
and is associated with29
the systemic inflammatory response29
the expression of cd29
we sought to determine29
our findings suggest that29
levels were measured by29
was significantly increased in29
a large number of29
in addition to the29
were included in this29
these data demonstrate that29
were observed in the29
was added to the29
are known to be29
play a major role29
in the formation of29
were more likely to28
mg kg body weight28
was supported by the28
patients with sepsis and28
length of stay in28
in the inflammatory response28
was not affected by28
to determine the effect28
for h at room28
be used as a28
did not affect the28
may be associated with28
it has been suggested28
length of icu stay28
significant increase in the28
plays a critical role28
of acute respiratory distress28
was significantly reduced in28
in the current study28
in the process of28
investigate the effects of28
to play an important28
as well as to28
alone or in combination28
cells as well as28
c bl j mice28
in the patients with28
an in vitro model28
used to determine the28
vg vd t cells28
to the control group28
were not significantly different27
our data indicate that27
adult respiratory distress syndrome27
these results demonstrate that27
play a pivotal role27
in the form of27
in response to the27
be related to the27
total of patients were27
than in the control27
may be related to27
plays a key role27
here we show that27
at different time points27
compared with the control27
there was no correlation27
we have developed a27
in a number of27
to the activation of27
balb c mice were27
were measured by elisa27
it was shown that27
significant difference between the27
was shown to be27
cells were incubated with27
is considered to be27
data suggest that the27
in order to identify27
to investigate the effect27
patients with acute respiratory27
was performed using the27
human umbilical vein endothelial27
we have found that27
duration of mechanical ventilation27
one of the major27
used to assess the26
the inflammatory response in26
was significantly associated with26
increase in the number26
of a variety of26
sepsis or septic shock26
in comparison to the26
or in combination with26
an increased risk of26
no significant differences between26
data were analyzed by26
care and use committee26
it is known that26
for the diagnosis of26
umbilical vein endothelial cells26
significantly increased in the26
investigated the role of26
plays a central role26
one of the main26
higher in patients with26
under the control of26
h after lps administration26
and the expression of26
involved in the pathogenesis26
associated with an increase26
multiple organ dysfunction syndrome26
test was used to25
acute lung injury by25
for the detection of25
results indicate that the25
and tumor necrosis factor25
be one of the25
innate and adaptive immune25
cd t cells in25
patients with and without25
the mrna expression of25
at least in part25
with the use of25
for the induction of25
reproductive and respiratory syndrome25
total rna was extracted25
are shown in table25
studies are needed to25
for a period of25
in a rat model25
a wide variety of25
used in this study25
patients were divided into25
the results of this25
the expression of il25
it is possible that25
the purpose of the25
the majority of patients25
porcine reproductive and respiratory25
these results show that25
at each time point25
was associated with an25
animal care and use24
to an increase in24
dose of mg kg24
high mobility group box24
at room temperature for24
area under the curve24
plays a crucial role24
of genes involved in24
in the acute phase24
was to compare the24
rna was extracted from24
the control of the24
previous studies have shown24
have been reported to24
a negative regulator of24
in line with the24
was used to assess24
of the role of24
appears to be a24
as one of the24
we could show that24
the early phase of24
we also found that24
in the levels of24
has been suggested that24
no difference in the24
to investigate the effects24
was no correlation between24
our understanding of the24
a risk factor for24
the authors declare that24
for the management of24
our results showed that24
significant difference in the24
a dose of mg24
assess the effect of24
the acute phase of23
to assess the effect23
and an increase in23
tested the hypothesis that23
is responsible for the23
in any of the23
of the femoral head23
was defined as a23
the number of patients23
were significantly increased in23
the production of tnf23
a significant role in23
the production of il23
we investigated the effect23
included in this study23
cells in response to23
cells were cultured in23
the levels of il23
and acute lung injury23
to the presence of23
was used to compare23
was approved by the23
during the first days23
to test this hypothesis22
is due to the22
production of proinflammatory cytokines22
mechanism of action of22
in an in vitro22
the level of the22
compared to the pbs22
which is associated with22
study is to evaluate22
as a marker of22
been found to be22
the production of inflammatory22
by means of a22
is based on the22
of the patients with22
with persistent pulmonary hypertension22
was to examine the22
but not in the22
was found in the22
may play an important22
contribute to the development22
the mean age was22
analysis was used to22
samples were collected from22
on the day of22
of multiple organ failure22
associated with a significant22
the formation of the22
in the setting of22
the mechanisms by which22
used for statistical analysis22
we set out to22
admitted to our icu22
reduce the incidence of22
results show that the22
the results suggest that22
in the united states22
major role in the22
is associated with the22
way analysis of variance22
in order to evaluate22
of the nlrp inflammasome22
in relation to the22
mortality in patients with22
with the control group22
and the development of22
is mediated by the22
have shown that the22
no significant difference between22
were no differences in22
correlation was found between22
by flow cytometry and21
on the presence of21
has no effect on21
better understanding of the21
we have investigated the21
the inhibition of the21
it is difficult to21
remains to be elucidated21
in the serum of21
admitted to the intensive21
the results indicate that21
that there is a21
study was to examine21
the results show that21
hospital length of stay21
and respiratory syndrome virus21
to better understand the21
evaluate the effects of21
inflammatory response in the21
might be due to21
a major cause of21
production of inflammatory cytokines21
women with a history21
in bronchoalveolar lavage fluid21
the importance of the21
the goal of this21
examine the effect of21
we have previously demonstrated21
to evaluate the effects21
induced lung injury in21
increased the number of21
the activation of nf21
the expression of a21
at the site of21
group of patients with21
newborn offspring with persistent21
mrna and protein levels21
play important roles in21
of tlr and tlr21
who were admitted to21
compared to wild type21
is the most common21
in a dose dependent21
with the severity of21
offspring with persistent pulmonary21
was not significantly different21
in order to investigate21
showed a significant increase21
on the role of21
at the onset of21
in intensive care unit21
the expression of pro21
and acute respiratory distress21
have been implicated in21
the presence of an21
shown to play a21
in animal models of21
data indicate that the21
a prospective observational study21
known to be involved21
and the use of21
plays a pivotal role21
study we investigated the21
the effect of a20
higher than that of20
examined the effect of20
significantly lower in the20
medical intensive care unit20
the early stages of20
a l p r20
the potential role of20
is required for the20
r n a l20
we tested the hypothesis20
an intensive care unit20
in the lung tissues20
pivotal role in the20
patients who did not20
are considered to be20
of the effects of20
and the effect of20
cells were stimulated with20
use of laboratory animals20
patients with liver cirrhosis20
critical role in the20
also been shown to20
cd t cells were20
higher than in the20
patients were admitted to20
during the development of20
the impact of the20
j o u r20
in the early phase20
this study aimed to20
n a l p20
the first days of20
the downregulation of palm20
of the patients were20
be used as an20
a reduction in the20
with respect to the20
of the patients who20
r o o f20
the presence of ibalt20
p r o o20
in comparison with the20
an essential role in20
treatment of patients with20
our data demonstrate that20
u r n a20
did not differ significantly20
we investigated the role20
l p r e20
to a lesser extent20
expression in response to20
for the identification of20
with the exception of20
o u r n20
to contribute to the20
sod g a mice20
care and use of20
plays a major role20
has been suggested to20
of chronic obstructive pulmonary19
key role in the19
of the most important19
shown to be a19
was to determine whether19
that they have no19
the beneficial effects of19
study was carried out19
a marked increase in19
in the small intestine19
to the formation of19
to examine the effect19
in the modulation of19
compared to control mice19
as compared to control19
the production of pro19
determine the effects of19
is to evaluate the19
at the cell surface19
patients with severe ards19
c bl mice were19
associated with a higher19
cytokines such as il19
during the first hours19
the ability of the19
are presented as mean19
as well as an19
our intensive care unit19
and multiple organ failure19
in a group of19
were isolated from the19
length of stay and19
compared with control group19
cd t cells and19
we show that the19
in the critically ill19
and use of laboratory19
which may contribute to19
has been identified as19
were significantly reduced in19
during the course of19
further studies are needed19
with an increased risk19
group than in the19
course of the disease19
severe acute respiratory syndrome19
stained with hematoxylin and19
declare that they have19
no significant changes in19
was detected in the19
studied the effects of19
of a number of19
the surface of the19
was measured by elisa19
a single dose of19
with regard to the18
mechanisms involved in the18
efficacy and safety of18
we aimed to investigate18
similar in both groups18
did not show any18
seems to be a18
with a decrease in18
the treatment of sepsis18
associated with increased mortality18
we have recently shown18
were randomized to receive18
in an attempt to18
the majority of the18
cause of death in18
in patients with liver18
induced by lps in18
in this group of18
order to determine the18
the mechanism of action18
as a function of18
through the activation of18
there was a trend18
the immune response to18
is characterized by a18
be explained by the18
in the lungs and18
data were analyzed using18
the first day of18
present study was designed18
total rna was isolated18
of patients with acute18
our findings indicate that18
osteonecrosis of the femoral18
that the presence of18
this work was to18
of morbidity and mortality18
samples were obtained from18
the cells were treated18
a significant decrease of18
a and s a18
is important for the18
to a decrease in18
this study aims to18
in vascular smooth muscle18
mhc class i molecules18
of the transcription factor18
was significantly lower than18
of inducible nitric oxide18
significant differences between the18
min at room temperature18
similar results were obtained18
the apache ii score18
significant differences in the18
and adaptive immune responses18
have been associated with18
this group of patients18
study was supported by18
in the emergency department18
the care and use18
to play a key18
the inflammatory response and18
an animal model of18
study was undertaken to18
the first hours after18
did not lead to18
in response to a18
authors declare that they18
a retrospective cohort study18
to be related to18
is believed to be18
of this work was18
not significantly different between18
have previously demonstrated that17
be responsible for the17
coronary artery bypass grafting17
over the course of17
the expression of these17
of neutrophils in the17
we conducted a prospective17
it was reported that17
we performed a retrospective17
high levels of il17
in the liver and17
in the postoperative period17
surgical intensive care unit17
area under the roc17
the inhibitory effects of17
which are involved in17
no significant differences were17
were approved by the17
in patients admitted to17
and oxidative stress in17
more than of the17
for the care and17
the levels of tnf17
were randomly divided into17
the nature of the17
these data show that17
the influence of the17
with a reduction in17
in balb c mice17
associated with a reduction17
in the present work17
from the lp group17
lung injury induced by17
the basis of the17
a positive correlation between17
were randomly assigned to17
and the activation of17
all patients admitted to17
of innate and adaptive17
in the generation of17
end of the experiment17
by the addition of17
was considered statistically significant17
we found a significant17
mice were subjected to17
studies have demonstrated that17
under the roc curve17
results of this study17
with hematoxylin and eosin17
in the early stages17
the functional role of17
was calculated as the17
was defined as the17
absence or presence of17
at the university of17
been identified as a17
and compared to the17
as compared to controls17
play a crucial role17
in mechanically ventilated patients17
with acute respiratory distress17
has been proposed as17
of sqad vite nps17
when compared to control17
a significant reduction of17
study was approved by17
was carried out in17
at a density of17
can be found in17
may be responsible for17
aimed to investigate the17
significant differences were found17
blood samples were taken17
the expression of tlr17
and the severity of17
was injected into the17
was used as an17
an important role of17
which are known to17
associated with a high17
for min at room17
in an animal model17
have been found to17
in the majority of17
in the first hours17
for the prevention of17
it is not clear17
study the effects of17
were used to determine17
the expression pattern of17
innate immune response to17
cd t cell responses16
were purchased from the16
implicated in the pathogenesis16
central role in the16
this article is protected16
experiments were performed in16
the leading cause of16
study is to investigate16
in view of the16
innate immune responses in16
new insights into the16
for up to h16
the expression of genes16
patients at risk of16
of gd t cells16
the vast majority of16
the adaptive immune response16
studies are required to16
those who did not16
were significantly lower in16
article is protected by16
days after lps injection16
the treatment of severe16
the molecular mechanisms underlying16
may be useful in16
is also involved in16
similar to that of16
more likely to have16
study was to identify16
of cytokines and chemokines16
was not statistically significant16
are thought to be16
have been identified as16
cd t cells to16
severe sepsis or septic16
has been demonstrated to16
way anova followed by16
difference between the two16
was assessed using the16
been shown to reduce16
of the patients had16
it has been proposed16
s a and s16
department of obstetrics and16
inflammatory cytokines such as16
investigate the impact of16
been shown to have16
after the end of16
but there was no16
specific cd and cd16
to the release of16
to determine the effects16
was no difference between16
in the maintenance of16
the presence of il16
of severe sepsis and16
is not associated with16
with the presence of16
model was used to16
length of hospital stay16
showed an increase in16
in vitro model of16
the therapeutic effect of16
a median age of16
is protected by copyright16
of red blood cells16
icu and hospital mortality16
an inhibitory effect on16
in of the patients16
the analysis of the16
for the expression of16
determined by flow cytometry16
within the first hours16
pcr and western blot16
remains to be determined16
in both cell types16
patients admitted to our16
the early stage of16
blood samples were obtained16
the first h of16
was higher in the16
the present study is16
challenged ttp ko mice16
no significant change in16
is a common complication16
the protective effects of16
to study the effects16
in the peripheral blood16
in the bone marrow16
a result of the16
we did not observe15
compound was identified as15
mice challenged with lps15
the cellular and molecular15
for more than days15
cells in the presence15
the first hours of15
has not yet been15
lps and poly i15
safety and efficacy of15
it has been demonstrated15
there was no statistical15
of the expression of15
hp and lp groups15
is a member of15
the authors declare no15
cells were exposed to15
not reach statistical significance15
to the site of15
on the level of15
induced the expression of15
changes in gene expression15
can be attributed to15
c a and c15
and to a lesser15
cultured in the presence15
results showed that the15
was used to measure15
compared to healthy controls15
sequential organ failure assessment15
the onset of the15
when compared with the15
expression of adhesion molecules15
samples were collected at15
was also found to15
for the assessment of15
cells were pretreated with15
to be important in15
the most common cause15
which is consistent with15
were used to assess15
were measured using a15
a retrospective analysis of15
can be divided into15
the pathogenesis of the15
a lethal dose of15
the pi k akt15
was used for statistical15
did not alter the15
the outer membrane of15
a number of studies15
and the release of15
statistical analyses were performed15
play a central role15
to be responsible for15
expression of genes involved15
is supported by the15
difference between the groups15
the mechanisms involved in15
aim of this work15
is the first study15
to determine whether the15
significantly higher than that15
study was to analyze15
length of stay was15
of obstetrics and gynecology15
be associated with the15
the relationship between the15
we hypothesized that the15
the pathogenesis of ali15
and negative predictive value15
was obtained from the15
cells were isolated from15
was inserted into the15
islets in nod mice15
for up to days15
were obtained from the15
are shown in the15
a significant correlation between15
after the administration of15
goal of this study15
is part of the15
the function of the15
as well as for15
the use of the15
in women with pcos15
apache ii score was15
for the control of15
has been demonstrated in15
that the use of15
most common cause of15
the role of this15
were detected in the15
has the potential to15
in our previous study15
were not able to15
associated with the development15
were used in the15
have recently shown that15
were divided into groups15
the number of cells15
and their role in15
in the two groups15
the first time the15
which is characterized by15
to assess the effects15
study was to describe15
to the severity of15
led to a significant15
it is necessary to15
the evaluation of the15
in the group of15
cause of morbidity and15
the molecular mechanisms of15
assess the effects of15
we have examined the15
that can be used15
the absence of any14
the production of the14
of texas medical branch14
serum levels of il14
determine the role of14
a reduction of the14
and has been shown14
the integrity of the14
during the first h14
at the beginning of14
was determined by the14
was assessed by the14
sections were stained with14
was measured using a14
the mrna levels of14
were present in the14
has been proposed to14
on the th day14
it is possible to14
from january to december14
as soon as possible14
to the production of14
test was used for14
for more than hours14
was used to detect14
were used in this14
with chronic obstructive pulmonary14
with the diagnosis of14
have a role in14
a final concentration of14
were stimulated with lps14
these results suggested that14
frozen in liquid nitrogen14
response and oxidative stress14
was lower in the14
the main cause of14
were enrolled in the14
an independent risk factor14
to study the effect14
been proposed as a14
has been found to14
might be involved in14
cytokines such as tnf14
cells of the innate14
the first h after14
the time of the14
did not reach statistical14
of nitric oxide synthase14
closely related to the14
to the role of14
evaluate the influence of14
with severe sepsis and14
it is not known14
was seen in the14
inflammation and oxidative stress14
this study was conducted14
of the gastrointestinal tract14
as a negative regulator14
in contrast to other14
a group of patients14
evaluate the impact of14
the protein expression of14
was performed using a14
and in patients with14
no statistically significant differences14
involved in the development14
the treatment of patients14
patients admitted to icu14
with acute renal failure14
the adult respiratory distress14
h and h after14
flow cytometric analysis of14
examine the effects of14
as a model for14
we did not find14
was measured by the14
to further investigate the14
this study was supported14
we observed that the14
morbidity and mortality in14
gestational age at delivery14
the production of cytokines14
the effects of a14
no conflict of interest14
investigated the impact of14
national institutes of health14
compared to those of14
term inhibition of dpp14
of patients with a14
pulmonary microvascular endothelial cells14
were no significant changes14
a potent inhibitor of14
inflammatory cytokines and chemokines14
the formation of a14
more likely to be14
a and c a14
of icu stay and14
cells stimulated with lps14
mean apache ii score14
for the generation of14
the lung tissues were14
the treatment of acute14
in the range of14
could be used as14
in cells treated with14
as well as by14
mode of action of14
university of texas medical14
in the dorsal funiculus14
analysis was performed with14
were added to the14
despite enhanced newborn offspring14
a systemic inflammatory response14
the safety and efficacy14
of our study is14
of the most common14
to be statistically significant14
to that observed in14
of the disease and14
enhanced newborn offspring with14
by real time pcr14
this study we investigated14
as a positive control14
the induction of apoptosis14
objectives of the study14
this study demonstrates that14
we examined the effect14
to participate in the14
was measured in the14
with acute lung injury14
in the lung and14
did not correlate with14
the serum levels of14
it is concluded that14
outcome of patients with14
in a university hospital14
on the development of14
in the absence or14
into the systemic circulation14
significantly higher than in14
we demonstrate that the14
diagnosis and treatment of14
until the end of14
in health and disease14
did not result in14
is the result of14
we studied the effects14
our study is to14
with the help of14
were cultured in the14
of the presence of14
are a family of14
it is unclear whether14
that the level of14
we previously reported that13
of inflammatory bowel disease13
were treated with a13
results are expressed as13
can be explained by13
the outcome of patients13
a protective role of13
was not influenced by13
in severe hepatitis patients13
mrna expression of the13
to the end of13
high morbidity and mortality13
during the acute phase13
in the immune response13
expression and function of13
as tumor necrosis factor13
has not been investigated13
it was demonstrated that13
and protein expression in13
no correlation was found13
in the progression of13
in order to improve13
role in the induction13
at the moment of13
compared to control animals13
the absence or presence13
for the study of13
which leads to the13
inflammatory response and oxidative13
the increased expression of13
to the fact that13
and the levels of13
as an indicator of13
expression of cd and13
the host response to13
at xg for minutes13
the efficacy of the13
compared with the hp13
of regulatory t cells13
compared to the lps13
endothelial nitric oxide synthase13
the cells were then13
were able to show13
have been suggested to13
been shown to induce13
was a significant difference13
lower than that of13
of inflammatory cells in13
have demonstrated that the13
the development of an13
during the period of13
be attributed to the13
the therapeutic potential of13
in the level of13
infection in patients with13
were similar in both13
the mean age of13
of proinflammatory cytokines and13
a history of early13
in the early postoperative13
was increased in the13
in addition to its13
a higher incidence of13
role in the pathophysiology13
and the percentage of13
to evaluate the influence13
in line with this13
patients with cirrhosis and13
expression of cd b13
associated with a decrease13
the first line of13
used as a model13
and then stimulated with13
apache ii and sofa13
as part of the13
infiltration of inflammatory cells13
to the induction of13
be taken into account13
production of reactive oxygen13
was not detected in13
in a decrease in13
pmcs in response to13
to determine the role13
have been described in13
a broad spectrum of13
with a diagnosis of13
significant reduction in the13
of the proinflammatory cytokines13
as measured by the13
and the incidence of13
has been reported in13
treatment of septic shock13
considered to be the13
we found that in13
patients admitted to a13
production of nitric oxide13
and h after the13
the primary outcome was13
a dose dependent manner13
by the administration of13
in combination with a13
to be the most13
differences between the groups13
with the number of13
for the activation of13
in cd t cells13
analysis was performed by13
significantly higher levels of13
t and b cells13
there was no effect13
is in line with13
in both groups of13
were associated with the13
in the culture medium13
to be expressed in13
in a significant increase13
the development of ali13
outer membrane of gram13
patients undergoing cardiac surgery13
in the lung tissue13
than that of the13
compared with that in13
and its role in13
as an inhibitor of13
at all time points13
in the icu and13
inflammatory responses in the13
in order to study13
in chronic obstructive pulmonary13
was also observed in13
and embedded in paraffin13
up to h after13
could be used to13
has previously been shown13
of the outer membrane13
here we demonstrate that13
this is due to13
the major cause of13
as a measure of13
of the actin cytoskeleton13
to investigate the impact13
was significantly decreased in13
study was conducted in13
the induction of the13
to the plasma membrane13
was to analyze the13
could be involved in13
may be a promising13
was extracted from the13
levels were measured using13
no differences in the13
for the regulation of13
mitogen activated protein kinase13
may be an important13
of patients with sepsis13
intensive care unit of13
on the one hand13
such as tumor necrosis13
cd t cells from13
studied the effect of13
are expressed as the13
cells of the immune13
were significantly decreased in13
findings suggest that the13
did not show a13
mean age was years13
is dependent on the13
with the occurrence of13
models of acute lung13
we have analyzed the13
differences were observed in13
were significantly higher than13
the data indicate that13
with different concentrations of13
on the production of13
in patients treated with13
with acute respiratory failure13
was used to evaluate13
due to the presence13
and smooth muscle cells13
critically ill patients is13
is consistent with the13
the host immune response13
turned out to be13
evaluate the role of13
it was possible to13
human pulmonary microvascular endothelial13
is due to a13
found to be significantly13
and a specificity of13
study the effect of13
women with and without13
the pei and pei13
prevention and treatment of13
induce the expression of13
with a median age13
we are currently investigating13
determined by western blot13
examined the role of13
the role of these13
analyses were performed using13
on the first day13
in c bl mice13
by the fact that13
a significant difference in13
stay in the icu13
used to evaluate the12
in the release of12
has been shown in12
in order to assess12
to the lps group12
molecular mechanisms involved in12
have the ability to12
of the menstrual cycle12
for at least h12
and this effect was12
may serve as a12
and the occurrence of12
has been demonstrated that12
is an important mediator12
in both wt and12
investigated the influence of12
simplified acute physiology score12
at different stages of12
in wild type mice12
increased the expression of12
median age of years12
cell types in the12
expression was measured by12
for a long time12
and h after lps12
due to the fact12
further studies are required12
did not change significantly12
be considered as a12
gene expression in the12
the application of the12
the identification of the12
in the percentage of12
of the dorsal funiculus12
experiments were carried out12
neutrophil recruitment to the12
glial fibrillary acidic protein12
was significantly reduced by12
nuclear factor kappa b12
arterial and mixed venous12
with that in the12
at the start of12
and tumour necrosis factor12
analyzed by flow cytometry12
and is involved in12
on the activation of12
as an internal control12
was associated with increased12
to a variety of12
the treatment of septic12
was higher in patients12
patients were treated with12
in the plasma membrane12
in the mouse lung12
presence and absence of12
of this study were12
with a variety of12
the lipid peroxide levels12
is related to the12
was to study the12
was added to each12
to be a major12
natural science foundation of12
and protein expression of12
despite the fact that12
physiology and chronic health12
have no competing interests12
can be used for12
the development of acute12
no statistically significant difference12
lower than in the12
inhibited the production of12
the patients in the12
for the presence of12
was a significant increase12
the development of sepsis12
were subjected to a12
patients were randomized to12
used to study the12
and use committee of12
a major component of12
was to describe the12
the in vivo situation12
of three independent experiments12
this was associated with12
has been studied in12
the important role of12
not significantly different from12
at g for min12
between innate and adaptive12
for h and then12
was carried out by12
was found that the12
in utero meconium passage12
and chronic health evaluation12
as well as other12
of the coagulation cascade12
in human endothelial cells12
no correlation between the12
fluorescence resonance energy transfer12
in the incidence of12
a change in the12
the absence of the12
at rpm for min12
recent evidence suggests that12
c h hej mice12
as well as on12
the production of no12
pellets were resuspended in12
is characterized by the12
mean arterial blood pressure12
to evaluate the efficacy12
to acute lung injury12
the implementation of the12
results of our study12
significantly different between the12
were incubated for h12
is a hallmark of12
changes in the expression12
was based on the12
in addition to their12
as well as their12
for each of the12
the hypothesis that the12
probably due to the12
it is believed that12
was similar in both12
cells were seeded in12
cxcr and cd l12
to the degree of12
a significant difference between12
at a rate of12
were used as controls12
and quality of life12
are associated with increased12
of influenza a virus12
of renal replacement therapy12
is likely to be12
was higher than in12
the inflammatory response to12
male wistar rats were12
the regulation of cell12
during the icu stay12
the absence of a12
after the introduction of12
were determined by elisa12
ultrasound stimulation of the12
as well as il12
aim was to investigate12
the release of pro12
order to evaluate the12
the two groups were12
guide for the care12
an important role for12
of the plasma membrane12
patients admitted in the12
a useful tool for12
for the use of12
incubated for h at12
in the brain and12
and may contribute to12
with severe head injury12
to the lack of12
order to investigate the12
in our intensive care12
patients at risk for12
to be regulated by12
a period of months12
to infiltrate into islets12
at the age of12
of the patients was12
in an intensive care12
number of patients with12
the present study demonstrated12
we and others have12
mice with and without12
acute physiology and chronic12
of stay in icu12
cells in vitro and12
the liver and spleen12
of the control group12
and reactive oxygen species12
the increase in the12
cd and cd cells12
of the complement system12
sections were incubated with12
in vitro effects of12
and mixed venous blood12
then stimulated with lps12
a high level of12
were treated with lps12
dna double strand breaks12
to examine the effects12
in the innate immune12
study we examined the12
show for the first12
was more pronounced in12
in the last years12
a potential therapeutic target12
increase in the expression12
define the role of12
were found in the12
the spinal cord of12
the lipid a moiety12
is closely related to12
the magnitude of the12
was not observed in12
for at least hours12
management of severe sepsis12
with lps and poly12
has also been shown12
epithelial and endothelial cells12
the possible role of12
can be considered as12
cells to infiltrate into12
blood samples were drawn12
we focused on the12
the cell surface and12
our findings show that12
cells were stained with12
the expression level of12
an experimental model of12
it is assumed that11
the result of the11
is known to induce11
over a month period11
the results of our11
from the bone marrow11
middle cerebral artery occlusion11
involved in this process11
compared to those in11
time pcr and western11
human peripheral blood mononuclear11
significantly reduced in the11
the following parameters were11
by cecal ligation and11
area under the receiver11
was performed with a11
the survival rate of11
the incidence of the11
levels were higher in11
may be caused by11
this study investigated the11
the mechanisms underlying the11
to play a major11
the start of the11
and their ability to11
and the outcome of11
did not change the11
levels of tumor necrosis11
immune and inflammatory responses11
were determined by western11
to be able to11
on the activity of11
and sitagliptin lps group11
can be induced by11
the expression of adhesion11
sought to determine the11
an important regulator of11
explore the role of11
through the use of11
b f melanoma cells11
inflammatory cells in the11
and a decrease in11
of cells in the11
to be increased in11
oxidative stress and inflammation11
for the maintenance of11
were identified in the11
we have previously reported11
membranes were incubated with11
also involved in the11
in the brain of11
was carried out on11
by grants from the11
the nuclear translocation of11
acute lung injury induced11
is not sufficient to11
in the amount of11
approved by the animal11
to be present in11
in this animal model11
end of the study11
there was an increase11
were used to identify11
was the most common11
be associated with a11
highly expressed in the11
which is involved in11
can be activated by11
has been proposed that11
is a major cause11
in order to reduce11
associated with high mortality11
is necessary for the11
is not clear whether11
have been reported in11
caused an increase in11
we observed a significant11
the percentage of cd11
of intensive care unit11
animals were sacrificed and11
which is known to11
the position of the11
male c bl mice11
the introduction of the11
that in addition to11
no difference between the11
of activin a in11
the molecular mechanisms involved11
enrolled in the study11
leads to the activation11
resulted in a decrease11
in the development and11
can be used in11
this study we have11
the accuracy of the11
university medical center groningen11
were used as control11
in a state of11
to be essential for11
in an increase in11
that the number of11
were no statistically significant11
levels of proinflammatory cytokines11
were significantly elevated in11
the plasma levels of11
and length of stay11
important roles in the11
understand the role of11
pulmonary surfactant protein sp11
an increased expression of11
leads to activation of11
to investigate whether the11
the pathogenesis of sepsis11
cells in the lung11
there was also a11
to act as a11
in the early stage11
is associated with high11
was used for the11
the presence of lps11
fatty acid and pl11
in comparison to control11
activation of the nlrp11
of patients were included11
for critically ill patients11
of protein kinase c11
levels were significantly increased11
in the face of11
at day after the11
is the most important11
total body surface area11
taking into account the11
was followed by a11
plays an essential role11
has not been reported11
in order to achieve11
examined the effects of11
is a risk factor11
is not due to11
contribute to the pathogenesis11
the efficacy and safety11
to reduce the incidence11
we can conclude that11
plates at a density11
of pulmonary surfactant protein11
between january and december11
in patients suffering from11
to determine the expression11
the pathophysiology of sepsis11
as an index of11
these results indicated that11
significantly higher than those11
significantly higher in patients11
male c bl j11
was determined using a11
centrifuged at rpm for11
protein expression in the11
we have studied the11
no differences were observed11
independent risk factor for11
has been observed in11
could be due to11
differences were found in11
on the effects of11
multiple organ failure in11
in the study group11
may be mediated by11
of the patients in11
a broad range of11
on the use of11
on admission to the11
in a previous study11
the promoter region of11
for a total of11
a prospective cohort study11
stimulation of the spleen11
less is known about11
age of the patients11
and the formation of11
to evaluate the impact11
there were no statistically11
for the indicated time11
is highly expressed in11
on the inflammatory response11
of patients treated with11
regulate the expression of11
with acute liver failure11
a consequence of the11
between survivors and non11
was measured using the11
and the production of11
thought to play a11
is the first report11
for at least days11
two groups of patients11
no significant difference was11
of hla class i11
of cd t cell11
has been related to11
under the receiver operating11
a flow rate of11
oxidative stress in the11
the beneficial effect of11
in an effort to11
have been proposed to11
as described in the11
evaluate the efficacy of11
of the extracellular matrix11
is accompanied by a11
was observed in patients11
sought to determine whether11
have also shown that11
statistically significant differences between11
sepsis and multiple organ11
arterial partial pressure of11
the role of il11
both groups of patients11
in mouse models of11
when compared to non11
crucial role in the11
during the process of11
as indicated by the11
and water ad libitum11
of the activation of11
in innate and adaptive11
we hypothesize that the11
cellular and molecular mechanisms11
type c bl mice11
response to lps stimulation11
the pathogenesis of ards11
for the initiation of11
is associated with significant11
was to determine if11
in the white matter11
production of inflammatory mediators11
of the adaptive immune11
a high fat diet11
and apache ii score11
within the first h11
critically ill patients and11
at the protein level11
the presence and absence11
levels were significantly higher11
used in the treatment11
in group a and11
involved in regulation of11
may be a useful11
from peripheral blood of11
have not yet been11
in the amygdala and11
the contribution of the11
challenged ttp are mice11
on day of gestation11
was identified as a11
cells in the lungs11
the secretion of il11
that the majority of11
the present study showed11
a p value of11
in the use of11
mice were challenged with11
pcr and western blotting11
been shown to inhibit11
of the effect of11
group compared with the11
study was conducted to11
to assess the impact11
present study demonstrated that11
none of the patients11
h after lps injection11
expression and activity of11
we previously showed that11
and then incubated with11
the underlying mechanism of11
of porcine reproductive and11
expression was determined by11
smooth muscle cells of11
institutional animal care and11
in the brains of11
due to the lack11
the outcome of the10
fold increase in the10
been shown to improve10
resulted in an increase10
in presence or absence10
vascular cell adhesion molecule10
a portion of the10
and the need for10
the lungs of mice10
and incubated for h10
were not affected by10
that the induction of10
time pcr was performed10
but had no effect10
to a lack of10
the best of our10
in intensive care patients10
a leading cause of10
the time of admission10
results are shown in10
respiratory distress syndrome in10
significantly lower than in10
rats were subjected to10
the onset of labour10
partial pressure of oxygen10
significantly decreased in the10
been related to the10
of severe sepsis in10
they have no competing10
this effect was not10
the peripheral nervous system10
were washed three times10
showed a significant decrease10
high performance liquid chromatography10
found in patients with10
suggest a role for10
such as multiple sclerosis10
in septic shock patients10
by western blotting and10
organ failure and death10
of the respiratory system10
expression of tlr and10
compared to the non10
the aims of this10
rats were divided into10
the rest of the10
have also been shown10
it is associated with10
the adaptive immune system10
play a significant role10
previously been shown to10
in severe sepsis and10
the development of onfh10
data were obtained from10
were considered to be10
in the ca region10
of central nervous system10
included in the analysis10
the upper and lower10
revealed the presence of10
in patients with or10
the changes in the10
the indicated time periods10
there is a growing10
and mean arterial pressure10
after the start of10
in experimental models of10
one of the following10
to evaluate the incidence10
been shown that the10
for the determination of10
be important in the10
supported by the dfg10
the development of new10
extract from folium isatidis10
effect of ginsenoside rb10
that is associated with10
on the effect of10
innate and adaptive its10
into the role of10
to the expression of10
the characteristics of the10
lung injury in rats10
lung tissues were harvested10
as a regulator of10
gd t cells in10
the mortality rate of10
with the aim of10
differences between groups were10
group and in the10
in a cohort of10
would like to thank10
in the diagnosis of10
at a final concentration10
and are involved in10
a growing body of10
for a number of10
was measured at nm10
levels were measured in10
of patients in the10
of oxidative stress and10
in spite of the10
growing body of evidence10
the response of the10
order to study the10
for more than h10
patients with or without10
a positive effect on10
differences in the expression10
over a year period10
were carried out in10
the absence of il10
a variety of cells10
the prevention and treatment10
during the first week10
patients with acute renal10
and contributes to the10
were excluded from the10
within the dorsal funiculus10
study the role of10
with sepsis and septic10
was determined by western10
the acute inflammatory response10
in both cell lines10
aim of this project10
with increased risk of10
time polymerase chain reaction10
as well as of10
measured before and after10
induced activation of the10
a period of years10
recent studies have shown10
after the injection of10
in the placebo group10
in the placenta and10
by a decrease in10
the interaction between the10
have been linked to10
the mode of action10
in the hippocampus of10
exacerbations of chronic obstructive10
detected in the lungs10
lower in patients with10
the difference between the10
mice were purchased from10
butanol extract from folium10
left ventricular ejection fraction10
support the hypothesis that10
and septic shock in10
the structure of the10
used to examine the10
could be detected in10
we have identified a10
a pulmonary artery catheter10
of patients who were10
a slight increase in10
leading cause of death10
these findings indicate that10
as compared to wt10
anesthesia and intensive care10
changes were observed in10
the correlation between the10
to the best of10
our goal was to10
we investigated the impact10
have the potential to10
the frequency of the10
in a significant reduction10
to be a promising10
the objective of the10
of microglia and astrocytes10
even in the absence10
the role of cd10
treatment of severe sepsis10
the incidence of vap10
the injection of lps10
to be due to10
best of our knowledge10
the length of icu10
a potential target for10
the need for a10
have been used to10
that are involved in10
the expression of several10
the fact that the10
support the concept that10
similar to that observed10
the cellular response to10
to determine if the10
observed in patients with10
of surfactant protein a10
patients of group a10
the number of total10
national natural science foundation10
were not different between10
in our study we10
was collected from the10
virus and or lps10
be due to a10
are presented as the10
be the result of10
the molecular basis of10
and to assess the10
here we investigated the10
the functionality of the10
klinische pharmakologie und toxikologie10
centrifuged at g for10
outcome in patients with10
the surviving sepsis campaign10
one of the key10
science foundation of china10
mean pulmonary artery pressure10
activated partial thromboplastin time10
a key factor in10
it was observed that10
expression is increased in10
significantly lower in patients10
there is evidence that10
of vascular smooth muscle10
in the prevention of10
the immune system and10
has been extensively studied10
blood of patients with10
findings of this study10
to the cell surface10
through the inhibition of10
in the presence and10
in mice treated with10
over the study period10
the findings of this10
were extracted from the10
the goal of the10
patients with chronic obstructive10
of high mobility group10
using an in vitro10
formation of reactive oxygen10
and at the end10
to evaluate the role10
the number of cd10
significantly higher than the10
weaning from mechanical ventilation10
the clinical course of10
male balb c mice10
model of acute lung10
that in the lps10
should be considered in10
of the intestinal mucosa10
and the rate of10
under the influence of10
of s a and10
the location of the10
the effect of this10
had at least one10
in a prospective study10
in the gastrointestinal tract10
have recently demonstrated that10
was significantly greater in10
was performed with the10
of the spinal cord10
the release of il10
of the p x10
have been used in10
und klinische pharmakologie und10
proinflammatory cytokines such as10
by the innate immune10
has been described as10
were washed with pbs10
the severity of sepsis10
demonstrate for the first10
statistical analysis was done10
and stimulated with lps10
studies have indicated that10
death in patients with10
to explore the role10
and mortality in patients10
the context of the10
the introduction of a10
to interfere with the10
a beneficial effect on10
we sought to identify10
used for the treatment10
a key regulator of10
is not involved in10
the patients with severe10
induced by lipopolysaccharide in10
to be mediated by10
be part of the10
within the normal range10
to the inhibition of10
gene expression in human10
in some of the10
outcomes in patients with10
prevent the development of10
of stay in the10
such as rheumatoid arthritis10
in combination with the10
for the measurement of10
due to differences in10
the most commonly used10
at various time points10
showed a significant reduction10
the predictive value of10
we have developed an10
other members of the10
to study the role10
that the effect of10
for the purpose of10
increases the risk of10
the early postoperative period10
cells were cultured for10
we would like to10
severity of the disease10
to a reduction of10
the data suggest that10
and function of the10
will be used to10
study was to establish10
on the type of10
for the production of10
serum of patients with10
on cd t cells10
this study was designed10
we examined the role10
found to inhibit the10
to its ability to10
inflammatory cytokines in the10
in the supernatant of10
we showed that the10
not differ significantly between10
for patients with severe10
the functional relevance of10
by the expression of10
study is to assess10
or a combination of10
been suggested to be10
aims of this study10
and to evaluate the10
their role in the10
the strength of the10
are required for the10
a high incidence of10
were used for statistical10
in the recognition of10
suggesting a role for10
among the three groups10
this study we examined10
brain microvascular endothelial cells10
with a combination of10
experimentelle und klinische pharmakologie10
with the hp group10
for the formation of10
of effector t cells10
the lung injury score10
to that of the10
which was associated with10
the aim was to10
in one of the10
in an in vivo10
room temperature for h10
caused a significant increase10
in mice challenged with10
shown to interact with9
were admitted to icu9
in the respiratory tract9
expression levels of the9
t cells to infiltrate9
the length of the9
factor in the pathogenesis9
shown in the table9
the physiological function of9
considered to be a9
phase of influenza infection9
with ng ml lps9
induced ards mice and9
the expression and function9
regulating the expression of9
rna was isolated from9
and the cells were9
not differ between the9
of mhc class i9
coronary artery bypass graft9
we prospectively studied patients9
significantly elevated in the9
the site of infection9
expression was significantly increased9
were found to have9
injury and acute respiratory9
prior to icu admission9
immune response in the9
as shown in table9
a variety of different9
evaluated the ability of9
at the mrna level9
may account for the9
of vascular endothelial growth9
single cell suspensions were9
are associated with the9
between the degree of9
reduced the incidence of9
was assessed in the9
associated with increased risk9
between patients with and9
was not due to9
to be independent of9
majority of patients with9
data show that the9
performed in order to9
the high level of9
to define the role9
surfactant proteins a and9
to investigate the potential9
results showed that lps9
t cell proliferation and9
in mouse and human9
of gene expression in9
found to be a9
is to assess the9
the treatment of the9
lipid peroxide levels and9
patients in intensive care9
role of nitric oxide9
risk factors associated with9
used in combination with9
does not appear to9
an increased incidence of9
we have evaluated the9
within the first days9
is critical for the9
positive cells in the9
from the peripheral blood9
study was to characterize9
as assessed by the9
increased the production of9
as a therapeutic target9
analyzed the effect of9
of the t cell9
the release of proinflammatory9
study demonstrates that the9
was carried out using9
guidelines for management of9
patients with severe acute9
to the emergency department9
have been described to9
patients with chronic liver9
maternal and fetal plasma9
from santa cruz biotechnology9
as in the case9
the specificity of the9
the deleterious effects of9
is regulated by the9
neutral with regard to9
we propose that the9
hours after lps injection9
and the induction of9
in a subset of9
study has shown that9
sought to determine if9
the combination of the9
of bacteria in the9
which are associated with9
used to investigate the9
informed consent was obtained9
of the fatty acid9
a statistically significant difference9
associated with changes in9
was a trend towards9
with or without lps9
do not appear to9
with the increase in9
with that of the9
during the first trimester9
is to investigate the9
our study suggests that9
in the fetal brain9
to the ability of9
no differences were found9
divided in two groups9
compared to wildtype mice9
different time points after9
was not different between9
in the rate of9
admitted to intensive care9
acid and pl synthesis9
data agreed with those9
purpose of the present9
for their ability to9
into the peritoneal cavity9