This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.
quadgram | frequency |
---|---|
in the presence of | 332 |
of this study was | 326 |
this study was to | 314 |
the aim of this | 288 |
aim of this study | 246 |
has been shown to | 212 |
in the present study | 210 |
an important role in | 195 |
in the pathogenesis of | 194 |
in the absence of | 179 |
acute respiratory distress syndrome | 178 |
as well as the | 177 |
for the treatment of | 163 |
on the other hand | 162 |
in the regulation of | 155 |
in vitro and in | 149 |
vitro and in vivo | 137 |
play a role in | 134 |
the aim of the | 128 |
at the time of | 125 |
in the treatment of | 125 |
at the end of | 122 |
these results suggest that | 121 |
in the development of | 118 |
in this study we | 117 |
in critically ill patients | 116 |
have been shown to | 116 |
play an important role | 114 |
as well as in | 113 |
is one of the | 112 |
been shown to be | 108 |
the present study was | 108 |
in the context of | 107 |
for the first time | 106 |
of the present study | 104 |
the central nervous system | 103 |
a significant increase in | 101 |
in the control group | 99 |
these data suggest that | 98 |
in patients with severe | 97 |
the intensive care unit | 94 |
study was to evaluate | 94 |
one of the most | 92 |
induced acute lung injury | 91 |
the purpose of this | 87 |
the expression of the | 86 |
of this study is | 86 |
the end of the | 86 |
there was no significant | 84 |
plays an important role | 84 |
was associated with a | 84 |
had no effect on | 81 |
purpose of this study | 80 |
aim of the present | 80 |
as a result of | 80 |
was found to be | 79 |
to the development of | 78 |
at the same time | 78 |
there was no difference | 78 |
chronic obstructive pulmonary disease | 78 |
for the development of | 76 |
studies have shown that | 76 |
present study was to | 76 |
a role in the | 76 |
study was to investigate | 76 |
the innate immune system | 75 |
important role in the | 75 |
admitted to the icu | 74 |
little is known about | 74 |
our results suggest that | 73 |
this study is to | 73 |
in the case of | 72 |
study was to determine | 72 |
was to evaluate the | 72 |
was to investigate the | 70 |
were found to be | 68 |
sepsis and septic shock | 68 |
a key role in | 68 |
to be involved in | 67 |
a total of patients | 67 |
presence or absence of | 65 |
patients with septic shock | 64 |
aim of the study | 64 |
peripheral blood mononuclear cells | 64 |
between the two groups | 64 |
is involved in the | 64 |
is associated with a | 63 |
may contribute to the | 63 |
no significant difference in | 63 |
the aim of our | 63 |
it has been shown | 62 |
of acute lung injury | 62 |
cells were treated with | 62 |
there were no significant | 62 |
of the study was | 62 |
of the innate immune | 62 |
in the number of | 61 |
we were able to | 60 |
a critical role in | 60 |
a mouse model of | 60 |
in the expression of | 60 |
in a mouse model | 60 |
these results indicate that | 59 |
in the intensive care | 59 |
role in the pathogenesis | 59 |
were included in the | 59 |
cd and cd t | 59 |
on the basis of | 59 |
involved in the regulation | 59 |
as shown in fig | 58 |
these findings suggest that | 58 |
was no significant difference | 58 |
in the lungs of | 58 |
the study was to | 58 |
was no difference in | 57 |
our results show that | 57 |
we have shown that | 57 |
patients admitted to the | 56 |
patients with severe hepatitis | 56 |
of our study was | 56 |
was to determine the | 56 |
has been reported to | 55 |
there was a significant | 55 |
on the surface of | 55 |
we found that the | 55 |
the role of the | 55 |
the objective of this | 55 |
are involved in the | 55 |
patients with severe sepsis | 54 |
aim of our study | 54 |
analysis was performed using | 54 |
an increase in the | 53 |
we have previously shown | 53 |
was used as a | 53 |
included in the study | 53 |
in response to lps | 53 |
be involved in the | 53 |
the presence or absence | 53 |
our data suggest that | 53 |
our results indicate that | 52 |
objective of this study | 52 |
vascular endothelial growth factor | 52 |
in vivo and in | 52 |
in patients with sepsis | 52 |
the present study we | 52 |
our study was to | 51 |
was significantly higher in | 51 |
is known about the | 51 |
as well as a | 50 |
in the central nervous | 50 |
and cd t cells | 50 |
statistical analysis was performed | 50 |
of reactive oxygen species | 50 |
to be associated with | 50 |
in the pathophysiology of | 50 |
of the immune system | 50 |
can be used to | 49 |
inducible nitric oxide synthase | 49 |
on the expression of | 48 |
has been shown that | 48 |
the innate immune response | 48 |
investigate the role of | 47 |
were significantly higher in | 47 |
it was found that | 47 |
this is the first | 46 |
a pivotal role in | 46 |
no significant differences in | 46 |
in a model of | 45 |
in accordance with the | 45 |
in acute lung injury | 45 |
these data indicate that | 45 |
a significant reduction in | 45 |
have previously shown that | 45 |
acute lung injury in | 45 |
plays a role in | 44 |
vivo and in vitro | 44 |
was observed in the | 44 |
data are expressed as | 44 |
results suggest that the | 44 |
our aim was to | 44 |
in the presence or | 43 |
a major role in | 43 |
in patients with acute | 43 |
vascular smooth muscle cells | 43 |
of cd t cells | 43 |
the regulation of the | 43 |
cecal ligation and puncture | 42 |
in patients with septic | 42 |
at the level of | 42 |
of critically ill patients | 42 |
of the immune response | 42 |
a member of the | 42 |
a significant decrease in | 42 |
associated with an increased | 42 |
a central role in | 41 |
of the inflammatory response | 41 |
divided into two groups | 41 |
in intensive care units | 41 |
severe sepsis and septic | 41 |
study was to assess | 41 |
patients were included in | 41 |
may play a role | 41 |
were no significant differences | 41 |
in a variety of | 41 |
the results showed that | 41 |
it has been reported | 40 |
resulted in a significant | 40 |
a wide range of | 40 |
over a period of | 40 |
investigated the effect of | 40 |
the total number of | 40 |
the presence of a | 40 |
to investigate the role | 40 |
is thought to be | 40 |
has been associated with | 40 |
lung injury in mice | 39 |
as a consequence of | 39 |
was to assess the | 39 |
with an increase in | 39 |
as compared to the | 38 |
is known to be | 38 |
on the cell surface | 38 |
in patients with cirrhosis | 38 |
there were no differences | 38 |
during the study period | 38 |
in the control of | 38 |
investigated the effects of | 38 |
may be due to | 38 |
to play a role | 38 |
the severity of the | 38 |
in the spinal cord | 37 |
no effect on the | 37 |
was significantly lower in | 37 |
the effect of the | 37 |
work was supported by | 37 |
may be involved in | 37 |
the area under the | 37 |
in the induction of | 37 |
the activation of the | 37 |
in the course of | 37 |
a crucial role in | 37 |
data are presented as | 37 |
in the production of | 36 |
a decrease in the | 36 |
the expression levels of | 36 |
the development of the | 36 |
is associated with an | 36 |
with the development of | 36 |
the mechanism by which | 36 |
the results of the | 35 |
the activity of the | 35 |
to the intensive care | 35 |
the acute respiratory distress | 35 |
are expressed as mean | 35 |
evaluate the effect of | 35 |
we conclude that the | 35 |
of tumor necrosis factor | 35 |
study was designed to | 35 |
test the hypothesis that | 35 |
systemic inflammatory response syndrome | 35 |
a murine model of | 35 |
by western blot analysis | 34 |
the inhibitory effect of | 34 |
it is important to | 34 |
we have demonstrated that | 34 |
be due to the | 34 |
at a dose of | 34 |
in the lps group | 34 |
before and after the | 34 |
to test the hypothesis | 34 |
after the onset of | 34 |
innate and adaptive immunity | 34 |
in the management of | 33 |
and the number of | 33 |
the effects of the | 33 |
has been reported that | 33 |
can be used as | 33 |
in contrast to the | 33 |
in order to determine | 33 |
play a key role | 33 |
is associated with increased | 33 |
role in the development | 33 |
of patients with severe | 33 |
tumor necrosis factor alpha | 33 |
blood samples were collected | 33 |
this work was supported | 33 |
with a mean age | 32 |
the course of the | 32 |
the first time that | 32 |
a significant increase of | 32 |
significantly higher in the | 32 |
in the activation of | 32 |
admission to the icu | 32 |
a better understanding of | 32 |
the protective effect of | 32 |
specific cd t cells | 32 |
investigate the effect of | 32 |
h after lps challenge | 32 |
study was to compare | 32 |
the presence of the | 32 |
we investigated the effects | 32 |
when compared to the | 32 |
to evaluate the effect | 32 |
acute lung injury and | 32 |
has been implicated in | 32 |
did not differ between | 31 |
university school of medicine | 31 |
in a murine model | 31 |
the time course of | 31 |
it is likely that | 31 |
a rat model of | 31 |
t cells in the | 31 |
was not associated with | 31 |
of patients admitted to | 31 |
with a history of | 31 |
by an increase in | 31 |
to the pathogenesis of | 31 |
our results demonstrate that | 31 |
of the central nervous | 31 |
at a concentration of | 31 |
play a critical role | 31 |
that the expression of | 31 |
and western blot analysis | 31 |
were admitted to the | 31 |
was used to determine | 31 |
in patients with chronic | 31 |
our objective was to | 31 |
well as in the | 30 |
of cd and cd | 30 |
h at room temperature | 30 |
a mean age of | 30 |
is essential for the | 30 |
critically ill patients with | 30 |
in the first h | 30 |
and the presence of | 30 |
mice were treated with | 30 |
role in the regulation | 30 |
the use of a | 30 |
were divided into two | 30 |
the development of a | 30 |
compared to the control | 30 |
determine the effect of | 30 |
our data show that | 30 |
by the use of | 30 |
icu length of stay | 30 |
by the presence of | 29 |
was significantly higher than | 29 |
been implicated in the | 29 |
both in vitro and | 29 |
mrna and protein expression | 29 |
been reported to be | 29 |
been shown to play | 29 |
at h after lps | 29 |
and is associated with | 29 |
the systemic inflammatory response | 29 |
the expression of cd | 29 |
we sought to determine | 29 |
our findings suggest that | 29 |
levels were measured by | 29 |
was significantly increased in | 29 |
a large number of | 29 |
in addition to the | 29 |
were included in this | 29 |
these data demonstrate that | 29 |
were observed in the | 29 |
was added to the | 29 |
are known to be | 29 |
play a major role | 29 |
in the formation of | 29 |
were more likely to | 28 |
mg kg body weight | 28 |
was supported by the | 28 |
patients with sepsis and | 28 |
length of stay in | 28 |
in the inflammatory response | 28 |
was not affected by | 28 |
to determine the effect | 28 |
for h at room | 28 |
be used as a | 28 |
did not affect the | 28 |
may be associated with | 28 |
it has been suggested | 28 |
length of icu stay | 28 |
significant increase in the | 28 |
plays a critical role | 28 |
of acute respiratory distress | 28 |
was significantly reduced in | 28 |
in the current study | 28 |
in the process of | 28 |
investigate the effects of | 28 |
to play an important | 28 |
as well as to | 28 |
alone or in combination | 28 |
cells as well as | 28 |
c bl j mice | 28 |
in the patients with | 28 |
an in vitro model | 28 |
used to determine the | 28 |
vg vd t cells | 28 |
to the control group | 28 |
were not significantly different | 27 |
our data indicate that | 27 |
adult respiratory distress syndrome | 27 |
these results demonstrate that | 27 |
play a pivotal role | 27 |
in the form of | 27 |
in response to the | 27 |
be related to the | 27 |
total of patients were | 27 |
than in the control | 27 |
may be related to | 27 |
plays a key role | 27 |
here we show that | 27 |
at different time points | 27 |
compared with the control | 27 |
there was no correlation | 27 |
we have developed a | 27 |
in a number of | 27 |
to the activation of | 27 |
balb c mice were | 27 |
were measured by elisa | 27 |
it was shown that | 27 |
significant difference between the | 27 |
was shown to be | 27 |
cells were incubated with | 27 |
is considered to be | 27 |
data suggest that the | 27 |
in order to identify | 27 |
to investigate the effect | 27 |
patients with acute respiratory | 27 |
was performed using the | 27 |
human umbilical vein endothelial | 27 |
we have found that | 27 |
duration of mechanical ventilation | 27 |
one of the major | 27 |
used to assess the | 26 |
the inflammatory response in | 26 |
was significantly associated with | 26 |
increase in the number | 26 |
of a variety of | 26 |
sepsis or septic shock | 26 |
in comparison to the | 26 |
or in combination with | 26 |
an increased risk of | 26 |
no significant differences between | 26 |
data were analyzed by | 26 |
care and use committee | 26 |
it is known that | 26 |
for the diagnosis of | 26 |
umbilical vein endothelial cells | 26 |
significantly increased in the | 26 |
investigated the role of | 26 |
plays a central role | 26 |
one of the main | 26 |
higher in patients with | 26 |
under the control of | 26 |
h after lps administration | 26 |
and the expression of | 26 |
involved in the pathogenesis | 26 |
associated with an increase | 26 |
multiple organ dysfunction syndrome | 26 |
test was used to | 25 |
acute lung injury by | 25 |
for the detection of | 25 |
results indicate that the | 25 |
and tumor necrosis factor | 25 |
be one of the | 25 |
innate and adaptive immune | 25 |
cd t cells in | 25 |
patients with and without | 25 |
the mrna expression of | 25 |
at least in part | 25 |
with the use of | 25 |
for the induction of | 25 |
reproductive and respiratory syndrome | 25 |
total rna was extracted | 25 |
are shown in table | 25 |
studies are needed to | 25 |
for a period of | 25 |
in a rat model | 25 |
a wide variety of | 25 |
used in this study | 25 |
patients were divided into | 25 |
the results of this | 25 |
the expression of il | 25 |
it is possible that | 25 |
the purpose of the | 25 |
the majority of patients | 25 |
porcine reproductive and respiratory | 25 |
these results show that | 25 |
at each time point | 25 |
was associated with an | 25 |
animal care and use | 24 |
to an increase in | 24 |
dose of mg kg | 24 |
high mobility group box | 24 |
at room temperature for | 24 |
area under the curve | 24 |
plays a crucial role | 24 |
of genes involved in | 24 |
in the acute phase | 24 |
was to compare the | 24 |
rna was extracted from | 24 |
the control of the | 24 |
previous studies have shown | 24 |
have been reported to | 24 |
a negative regulator of | 24 |
in line with the | 24 |
was used to assess | 24 |
of the role of | 24 |
appears to be a | 24 |
as one of the | 24 |
we could show that | 24 |
the early phase of | 24 |
we also found that | 24 |
in the levels of | 24 |
has been suggested that | 24 |
no difference in the | 24 |
to investigate the effects | 24 |
was no correlation between | 24 |
our understanding of the | 24 |
a risk factor for | 24 |
the authors declare that | 24 |
for the management of | 24 |
our results showed that | 24 |
significant difference in the | 24 |
a dose of mg | 24 |
assess the effect of | 24 |
the acute phase of | 23 |
to assess the effect | 23 |
and an increase in | 23 |
tested the hypothesis that | 23 |
is responsible for the | 23 |
in any of the | 23 |
of the femoral head | 23 |
was defined as a | 23 |
the number of patients | 23 |
were significantly increased in | 23 |
the production of tnf | 23 |
a significant role in | 23 |
the production of il | 23 |
we investigated the effect | 23 |
included in this study | 23 |
cells in response to | 23 |
cells were cultured in | 23 |
the levels of il | 23 |
and acute lung injury | 23 |
to the presence of | 23 |
was used to compare | 23 |
was approved by the | 23 |
during the first days | 23 |
to test this hypothesis | 22 |
is due to the | 22 |
production of proinflammatory cytokines | 22 |
mechanism of action of | 22 |
in an in vitro | 22 |
the level of the | 22 |
compared to the pbs | 22 |
which is associated with | 22 |
study is to evaluate | 22 |
as a marker of | 22 |
been found to be | 22 |
the production of inflammatory | 22 |
by means of a | 22 |
is based on the | 22 |
of the patients with | 22 |
with persistent pulmonary hypertension | 22 |
was to examine the | 22 |
but not in the | 22 |
was found in the | 22 |
may play an important | 22 |
contribute to the development | 22 |
the mean age was | 22 |
analysis was used to | 22 |
samples were collected from | 22 |
on the day of | 22 |
of multiple organ failure | 22 |
associated with a significant | 22 |
the formation of the | 22 |
in the setting of | 22 |
the mechanisms by which | 22 |
used for statistical analysis | 22 |
we set out to | 22 |
admitted to our icu | 22 |
reduce the incidence of | 22 |
results show that the | 22 |
the results suggest that | 22 |
in the united states | 22 |
major role in the | 22 |
is associated with the | 22 |
way analysis of variance | 22 |
in order to evaluate | 22 |
of the nlrp inflammasome | 22 |
in relation to the | 22 |
mortality in patients with | 22 |
with the control group | 22 |
and the development of | 22 |
is mediated by the | 22 |
have shown that the | 22 |
no significant difference between | 22 |
were no differences in | 22 |
correlation was found between | 22 |
by flow cytometry and | 21 |
on the presence of | 21 |
has no effect on | 21 |
better understanding of the | 21 |
we have investigated the | 21 |
the inhibition of the | 21 |
it is difficult to | 21 |
remains to be elucidated | 21 |
in the serum of | 21 |
admitted to the intensive | 21 |
the results indicate that | 21 |
that there is a | 21 |
study was to examine | 21 |
the results show that | 21 |
hospital length of stay | 21 |
and respiratory syndrome virus | 21 |
to better understand the | 21 |
evaluate the effects of | 21 |
inflammatory response in the | 21 |
might be due to | 21 |
a major cause of | 21 |
production of inflammatory cytokines | 21 |
women with a history | 21 |
in bronchoalveolar lavage fluid | 21 |
the importance of the | 21 |
the goal of this | 21 |
examine the effect of | 21 |
we have previously demonstrated | 21 |
to evaluate the effects | 21 |
induced lung injury in | 21 |
increased the number of | 21 |
the activation of nf | 21 |
the expression of a | 21 |
at the site of | 21 |
group of patients with | 21 |
newborn offspring with persistent | 21 |
mrna and protein levels | 21 |
play important roles in | 21 |
of tlr and tlr | 21 |
who were admitted to | 21 |
compared to wild type | 21 |
is the most common | 21 |
in a dose dependent | 21 |
with the severity of | 21 |
offspring with persistent pulmonary | 21 |
was not significantly different | 21 |
in order to investigate | 21 |
showed a significant increase | 21 |
on the role of | 21 |
at the onset of | 21 |
in intensive care unit | 21 |
the expression of pro | 21 |
and acute respiratory distress | 21 |
have been implicated in | 21 |
the presence of an | 21 |
shown to play a | 21 |
in animal models of | 21 |
data indicate that the | 21 |
a prospective observational study | 21 |
known to be involved | 21 |
and the use of | 21 |
plays a pivotal role | 21 |
study we investigated the | 21 |
the effect of a | 20 |
higher than that of | 20 |
examined the effect of | 20 |
significantly lower in the | 20 |
medical intensive care unit | 20 |
the early stages of | 20 |
a l p r | 20 |
the potential role of | 20 |
is required for the | 20 |
r n a l | 20 |
we tested the hypothesis | 20 |
an intensive care unit | 20 |
in the lung tissues | 20 |
pivotal role in the | 20 |
patients who did not | 20 |
are considered to be | 20 |
of the effects of | 20 |
and the effect of | 20 |
cells were stimulated with | 20 |
use of laboratory animals | 20 |
patients with liver cirrhosis | 20 |
critical role in the | 20 |
also been shown to | 20 |
cd t cells were | 20 |
higher than in the | 20 |
patients were admitted to | 20 |
during the development of | 20 |
the impact of the | 20 |
j o u r | 20 |
in the early phase | 20 |
this study aimed to | 20 |
n a l p | 20 |
the first days of | 20 |
the downregulation of palm | 20 |
of the patients were | 20 |
be used as an | 20 |
a reduction in the | 20 |
with respect to the | 20 |
of the patients who | 20 |
r o o f | 20 |
the presence of ibalt | 20 |
p r o o | 20 |
in comparison with the | 20 |
an essential role in | 20 |
treatment of patients with | 20 |
our data demonstrate that | 20 |
u r n a | 20 |
did not differ significantly | 20 |
we investigated the role | 20 |
l p r e | 20 |
to a lesser extent | 20 |
expression in response to | 20 |
for the identification of | 20 |
with the exception of | 20 |
o u r n | 20 |
to contribute to the | 20 |
sod g a mice | 20 |
care and use of | 20 |
plays a major role | 20 |
has been suggested to | 20 |
of chronic obstructive pulmonary | 19 |
key role in the | 19 |
of the most important | 19 |
shown to be a | 19 |
was to determine whether | 19 |
that they have no | 19 |
the beneficial effects of | 19 |
study was carried out | 19 |
a marked increase in | 19 |
in the small intestine | 19 |
to the formation of | 19 |
to examine the effect | 19 |
in the modulation of | 19 |
compared to control mice | 19 |
as compared to control | 19 |
the production of pro | 19 |
determine the effects of | 19 |
is to evaluate the | 19 |
at the cell surface | 19 |
patients with severe ards | 19 |
c bl mice were | 19 |
associated with a higher | 19 |
cytokines such as il | 19 |
during the first hours | 19 |
the ability of the | 19 |
are presented as mean | 19 |
as well as an | 19 |
our intensive care unit | 19 |
and multiple organ failure | 19 |
in a group of | 19 |
were isolated from the | 19 |
length of stay and | 19 |
compared with control group | 19 |
cd t cells and | 19 |
we show that the | 19 |
in the critically ill | 19 |
and use of laboratory | 19 |
which may contribute to | 19 |
has been identified as | 19 |
were significantly reduced in | 19 |
during the course of | 19 |
further studies are needed | 19 |
with an increased risk | 19 |
group than in the | 19 |
course of the disease | 19 |
severe acute respiratory syndrome | 19 |
stained with hematoxylin and | 19 |
declare that they have | 19 |
no significant changes in | 19 |
was detected in the | 19 |
studied the effects of | 19 |
of a number of | 19 |
the surface of the | 19 |
was measured by elisa | 19 |
a single dose of | 19 |
with regard to the | 18 |
mechanisms involved in the | 18 |
efficacy and safety of | 18 |
we aimed to investigate | 18 |
similar in both groups | 18 |
did not show any | 18 |
seems to be a | 18 |
with a decrease in | 18 |
the treatment of sepsis | 18 |
associated with increased mortality | 18 |
we have recently shown | 18 |
were randomized to receive | 18 |
in an attempt to | 18 |
the majority of the | 18 |
cause of death in | 18 |
in patients with liver | 18 |
induced by lps in | 18 |
in this group of | 18 |
order to determine the | 18 |
the mechanism of action | 18 |
as a function of | 18 |
through the activation of | 18 |
there was a trend | 18 |
the immune response to | 18 |
is characterized by a | 18 |
be explained by the | 18 |
in the lungs and | 18 |
data were analyzed using | 18 |
the first day of | 18 |
present study was designed | 18 |
total rna was isolated | 18 |
of patients with acute | 18 |
our findings indicate that | 18 |
osteonecrosis of the femoral | 18 |
that the presence of | 18 |
this work was to | 18 |
of morbidity and mortality | 18 |
samples were obtained from | 18 |
the cells were treated | 18 |
a significant decrease of | 18 |
a and s a | 18 |
is important for the | 18 |
to a decrease in | 18 |
this study aims to | 18 |
in vascular smooth muscle | 18 |
mhc class i molecules | 18 |
of the transcription factor | 18 |
was significantly lower than | 18 |
of inducible nitric oxide | 18 |
significant differences between the | 18 |
min at room temperature | 18 |
similar results were obtained | 18 |
the apache ii score | 18 |
significant differences in the | 18 |
and adaptive immune responses | 18 |
have been associated with | 18 |
this group of patients | 18 |
study was supported by | 18 |
in the emergency department | 18 |
the care and use | 18 |
to play a key | 18 |
the inflammatory response and | 18 |
an animal model of | 18 |
study was undertaken to | 18 |
the first hours after | 18 |
did not lead to | 18 |
in response to a | 18 |
authors declare that they | 18 |
a retrospective cohort study | 18 |
to be related to | 18 |
is believed to be | 18 |
of this work was | 18 |
not significantly different between | 18 |
have previously demonstrated that | 17 |
be responsible for the | 17 |
coronary artery bypass grafting | 17 |
over the course of | 17 |
the expression of these | 17 |
of neutrophils in the | 17 |
we conducted a prospective | 17 |
it was reported that | 17 |
we performed a retrospective | 17 |
high levels of il | 17 |
in the liver and | 17 |
in the postoperative period | 17 |
surgical intensive care unit | 17 |
area under the roc | 17 |
the inhibitory effects of | 17 |
which are involved in | 17 |
no significant differences were | 17 |
were approved by the | 17 |
in patients admitted to | 17 |
and oxidative stress in | 17 |
more than of the | 17 |
for the care and | 17 |
the levels of tnf | 17 |
were randomly divided into | 17 |
the nature of the | 17 |
these data show that | 17 |
the influence of the | 17 |
with a reduction in | 17 |
in balb c mice | 17 |
associated with a reduction | 17 |
in the present work | 17 |
from the lp group | 17 |
lung injury induced by | 17 |
the basis of the | 17 |
a positive correlation between | 17 |
were randomly assigned to | 17 |
and the activation of | 17 |
all patients admitted to | 17 |
of innate and adaptive | 17 |
in the generation of | 17 |
end of the experiment | 17 |
by the addition of | 17 |
was considered statistically significant | 17 |
we found a significant | 17 |
mice were subjected to | 17 |
studies have demonstrated that | 17 |
under the roc curve | 17 |
results of this study | 17 |
with hematoxylin and eosin | 17 |
in the early stages | 17 |
the functional role of | 17 |
was calculated as the | 17 |
was defined as the | 17 |
absence or presence of | 17 |
at the university of | 17 |
been identified as a | 17 |
and compared to the | 17 |
as compared to controls | 17 |
play a crucial role | 17 |
in mechanically ventilated patients | 17 |
with acute respiratory distress | 17 |
has been proposed as | 17 |
of sqad vite nps | 17 |
when compared to control | 17 |
a significant reduction of | 17 |
study was approved by | 17 |
was carried out in | 17 |
at a density of | 17 |
can be found in | 17 |
may be responsible for | 17 |
aimed to investigate the | 17 |
significant differences were found | 17 |
blood samples were taken | 17 |
the expression of tlr | 17 |
and the severity of | 17 |
was injected into the | 17 |
was used as an | 17 |
an important role of | 17 |
which are known to | 17 |
associated with a high | 17 |
for min at room | 17 |
in an animal model | 17 |
have been found to | 17 |
in the majority of | 17 |
in the first hours | 17 |
for the prevention of | 17 |
it is not clear | 17 |
study the effects of | 17 |
were used to determine | 17 |
the expression pattern of | 17 |
innate immune response to | 17 |
cd t cell responses | 16 |
were purchased from the | 16 |
implicated in the pathogenesis | 16 |
central role in the | 16 |
this article is protected | 16 |
experiments were performed in | 16 |
the leading cause of | 16 |
study is to investigate | 16 |
in view of the | 16 |
innate immune responses in | 16 |
new insights into the | 16 |
for up to h | 16 |
the expression of genes | 16 |
patients at risk of | 16 |
of gd t cells | 16 |
the vast majority of | 16 |
the adaptive immune response | 16 |
studies are required to | 16 |
those who did not | 16 |
were significantly lower in | 16 |
article is protected by | 16 |
days after lps injection | 16 |
the treatment of severe | 16 |
the molecular mechanisms underlying | 16 |
may be useful in | 16 |
is also involved in | 16 |
similar to that of | 16 |
more likely to have | 16 |
study was to identify | 16 |
of cytokines and chemokines | 16 |
was not statistically significant | 16 |
are thought to be | 16 |
have been identified as | 16 |
cd t cells to | 16 |
severe sepsis or septic | 16 |
has been demonstrated to | 16 |
way anova followed by | 16 |
difference between the two | 16 |
was assessed using the | 16 |
been shown to reduce | 16 |
of the patients had | 16 |
it has been proposed | 16 |
s a and s | 16 |
department of obstetrics and | 16 |
inflammatory cytokines such as | 16 |
investigate the impact of | 16 |
been shown to have | 16 |
after the end of | 16 |
but there was no | 16 |
specific cd and cd | 16 |
to the release of | 16 |
to determine the effects | 16 |
was no difference between | 16 |
in the maintenance of | 16 |
the presence of il | 16 |
of severe sepsis and | 16 |
is not associated with | 16 |
with the presence of | 16 |
model was used to | 16 |
length of hospital stay | 16 |
showed an increase in | 16 |
in vitro model of | 16 |
the therapeutic effect of | 16 |
a median age of | 16 |
is protected by copyright | 16 |
of red blood cells | 16 |
icu and hospital mortality | 16 |
an inhibitory effect on | 16 |
in of the patients | 16 |
the analysis of the | 16 |
for the expression of | 16 |
determined by flow cytometry | 16 |
within the first hours | 16 |
pcr and western blot | 16 |
remains to be determined | 16 |
in both cell types | 16 |
patients admitted to our | 16 |
the early stage of | 16 |
blood samples were obtained | 16 |
the first h of | 16 |
was higher in the | 16 |
the present study is | 16 |
challenged ttp ko mice | 16 |
no significant change in | 16 |
is a common complication | 16 |
the protective effects of | 16 |
to study the effects | 16 |
in the peripheral blood | 16 |
in the bone marrow | 16 |
a result of the | 16 |
we did not observe | 15 |
compound was identified as | 15 |
mice challenged with lps | 15 |
the cellular and molecular | 15 |
for more than days | 15 |
cells in the presence | 15 |
the first hours of | 15 |
has not yet been | 15 |
lps and poly i | 15 |
safety and efficacy of | 15 |
it has been demonstrated | 15 |
there was no statistical | 15 |
of the expression of | 15 |
hp and lp groups | 15 |
is a member of | 15 |
the authors declare no | 15 |
cells were exposed to | 15 |
not reach statistical significance | 15 |
to the site of | 15 |
on the level of | 15 |
induced the expression of | 15 |
changes in gene expression | 15 |
can be attributed to | 15 |
c a and c | 15 |
and to a lesser | 15 |
cultured in the presence | 15 |
results showed that the | 15 |
was used to measure | 15 |
compared to healthy controls | 15 |
sequential organ failure assessment | 15 |
the onset of the | 15 |
when compared with the | 15 |
expression of adhesion molecules | 15 |
samples were collected at | 15 |
was also found to | 15 |
for the assessment of | 15 |
cells were pretreated with | 15 |
to be important in | 15 |
the most common cause | 15 |
which is consistent with | 15 |
were used to assess | 15 |
were measured using a | 15 |
a retrospective analysis of | 15 |
can be divided into | 15 |
the pathogenesis of the | 15 |
a lethal dose of | 15 |
the pi k akt | 15 |
was used for statistical | 15 |
did not alter the | 15 |
the outer membrane of | 15 |
a number of studies | 15 |
and the release of | 15 |
statistical analyses were performed | 15 |
play a central role | 15 |
to be responsible for | 15 |
expression of genes involved | 15 |
is supported by the | 15 |
difference between the groups | 15 |
the mechanisms involved in | 15 |
aim of this work | 15 |
is the first study | 15 |
to determine whether the | 15 |
significantly higher than that | 15 |
study was to analyze | 15 |
length of stay was | 15 |
of obstetrics and gynecology | 15 |
be associated with the | 15 |
the relationship between the | 15 |
we hypothesized that the | 15 |
the pathogenesis of ali | 15 |
and negative predictive value | 15 |
was obtained from the | 15 |
cells were isolated from | 15 |
was inserted into the | 15 |
islets in nod mice | 15 |
for up to days | 15 |
were obtained from the | 15 |
are shown in the | 15 |
a significant correlation between | 15 |
after the administration of | 15 |
goal of this study | 15 |
is part of the | 15 |
the function of the | 15 |
as well as for | 15 |
the use of the | 15 |
in women with pcos | 15 |
apache ii score was | 15 |
for the control of | 15 |
has been demonstrated in | 15 |
that the use of | 15 |
most common cause of | 15 |
the role of this | 15 |
were detected in the | 15 |
has the potential to | 15 |
in our previous study | 15 |
were not able to | 15 |
associated with the development | 15 |
were used in the | 15 |
have recently shown that | 15 |
were divided into groups | 15 |
the number of cells | 15 |
and their role in | 15 |
in the two groups | 15 |
the first time the | 15 |
which is characterized by | 15 |
to assess the effects | 15 |
study was to describe | 15 |
to the severity of | 15 |
led to a significant | 15 |
it is necessary to | 15 |
the evaluation of the | 15 |
in the group of | 15 |
cause of morbidity and | 15 |
the molecular mechanisms of | 15 |
assess the effects of | 15 |
we have examined the | 15 |
that can be used | 15 |
the absence of any | 14 |
the production of the | 14 |
of texas medical branch | 14 |
serum levels of il | 14 |
determine the role of | 14 |
a reduction of the | 14 |
and has been shown | 14 |
the integrity of the | 14 |
during the first h | 14 |
at the beginning of | 14 |
was determined by the | 14 |
was assessed by the | 14 |
sections were stained with | 14 |
was measured using a | 14 |
the mrna levels of | 14 |
were present in the | 14 |
has been proposed to | 14 |
on the th day | 14 |
it is possible to | 14 |
from january to december | 14 |
as soon as possible | 14 |
to the production of | 14 |
test was used for | 14 |
for more than hours | 14 |
was used to detect | 14 |
were used in this | 14 |
with chronic obstructive pulmonary | 14 |
with the diagnosis of | 14 |
have a role in | 14 |
a final concentration of | 14 |
were stimulated with lps | 14 |
these results suggested that | 14 |
frozen in liquid nitrogen | 14 |
response and oxidative stress | 14 |
was lower in the | 14 |
the main cause of | 14 |
were enrolled in the | 14 |
an independent risk factor | 14 |
to study the effect | 14 |
been proposed as a | 14 |
has been found to | 14 |
might be involved in | 14 |
cytokines such as tnf | 14 |
cells of the innate | 14 |
the first h after | 14 |
the time of the | 14 |
did not reach statistical | 14 |
of nitric oxide synthase | 14 |
closely related to the | 14 |
to the role of | 14 |
evaluate the influence of | 14 |
with severe sepsis and | 14 |
it is not known | 14 |
was seen in the | 14 |
inflammation and oxidative stress | 14 |
this study was conducted | 14 |
of the gastrointestinal tract | 14 |
as a negative regulator | 14 |
in contrast to other | 14 |
a group of patients | 14 |
evaluate the impact of | 14 |
the protein expression of | 14 |
was performed using a | 14 |
and in patients with | 14 |
no statistically significant differences | 14 |
involved in the development | 14 |
the treatment of patients | 14 |
patients admitted to icu | 14 |
with acute renal failure | 14 |
the adult respiratory distress | 14 |
h and h after | 14 |
flow cytometric analysis of | 14 |
examine the effects of | 14 |
as a model for | 14 |
we did not find | 14 |
was measured by the | 14 |
to further investigate the | 14 |
this study was supported | 14 |
we observed that the | 14 |
morbidity and mortality in | 14 |
gestational age at delivery | 14 |
the production of cytokines | 14 |
the effects of a | 14 |
no conflict of interest | 14 |
investigated the impact of | 14 |
national institutes of health | 14 |
compared to those of | 14 |
term inhibition of dpp | 14 |
of patients with a | 14 |
pulmonary microvascular endothelial cells | 14 |
were no significant changes | 14 |
a potent inhibitor of | 14 |
inflammatory cytokines and chemokines | 14 |
the formation of a | 14 |
more likely to be | 14 |
a and c a | 14 |
of icu stay and | 14 |
cells stimulated with lps | 14 |
mean apache ii score | 14 |
for the generation of | 14 |
the lung tissues were | 14 |
the treatment of acute | 14 |
in the range of | 14 |
could be used as | 14 |
in cells treated with | 14 |
as well as by | 14 |
mode of action of | 14 |
university of texas medical | 14 |
in the dorsal funiculus | 14 |
analysis was performed with | 14 |
were added to the | 14 |
despite enhanced newborn offspring | 14 |
a systemic inflammatory response | 14 |
the safety and efficacy | 14 |
of our study is | 14 |
of the most common | 14 |
to be statistically significant | 14 |
to that observed in | 14 |
of the disease and | 14 |
enhanced newborn offspring with | 14 |
by real time pcr | 14 |
this study we investigated | 14 |
as a positive control | 14 |
the induction of apoptosis | 14 |
objectives of the study | 14 |
this study demonstrates that | 14 |
we examined the effect | 14 |
to participate in the | 14 |
was measured in the | 14 |
with acute lung injury | 14 |
in the lung and | 14 |
did not correlate with | 14 |
the serum levels of | 14 |
it is concluded that | 14 |
outcome of patients with | 14 |
in a university hospital | 14 |
on the development of | 14 |
in the absence or | 14 |
into the systemic circulation | 14 |
significantly higher than in | 14 |
we demonstrate that the | 14 |
diagnosis and treatment of | 14 |
until the end of | 14 |
in health and disease | 14 |
did not result in | 14 |
is the result of | 14 |
we studied the effects | 14 |
our study is to | 14 |
with the help of | 14 |
were cultured in the | 14 |
of the presence of | 14 |
are a family of | 14 |
it is unclear whether | 14 |
that the level of | 14 |
we previously reported that | 13 |
of inflammatory bowel disease | 13 |
were treated with a | 13 |
results are expressed as | 13 |
can be explained by | 13 |
the outcome of patients | 13 |
a protective role of | 13 |
was not influenced by | 13 |
in severe hepatitis patients | 13 |
mrna expression of the | 13 |
to the end of | 13 |
high morbidity and mortality | 13 |
during the acute phase | 13 |
in the immune response | 13 |
expression and function of | 13 |
as tumor necrosis factor | 13 |
has not been investigated | 13 |
it was demonstrated that | 13 |
and protein expression in | 13 |
no correlation was found | 13 |
in the progression of | 13 |
in order to improve | 13 |
role in the induction | 13 |
at the moment of | 13 |
compared to control animals | 13 |
the absence or presence | 13 |
for the study of | 13 |
which leads to the | 13 |
inflammatory response and oxidative | 13 |
the increased expression of | 13 |
to the fact that | 13 |
and the levels of | 13 |
as an indicator of | 13 |
expression of cd and | 13 |
the host response to | 13 |
at xg for minutes | 13 |
the efficacy of the | 13 |
compared with the hp | 13 |
of regulatory t cells | 13 |
compared to the lps | 13 |
endothelial nitric oxide synthase | 13 |
the cells were then | 13 |
were able to show | 13 |
have been suggested to | 13 |
been shown to induce | 13 |
was a significant difference | 13 |
lower than that of | 13 |
of inflammatory cells in | 13 |
have demonstrated that the | 13 |
the development of an | 13 |
during the period of | 13 |
be attributed to the | 13 |
the therapeutic potential of | 13 |
in the level of | 13 |
infection in patients with | 13 |
were similar in both | 13 |
the mean age of | 13 |
of proinflammatory cytokines and | 13 |
a history of early | 13 |
in the early postoperative | 13 |
was increased in the | 13 |
in addition to its | 13 |
a higher incidence of | 13 |
role in the pathophysiology | 13 |
and the percentage of | 13 |
to evaluate the influence | 13 |
in line with this | 13 |
patients with cirrhosis and | 13 |
expression of cd b | 13 |
associated with a decrease | 13 |
the first line of | 13 |
used as a model | 13 |
and then stimulated with | 13 |
apache ii and sofa | 13 |
as part of the | 13 |
infiltration of inflammatory cells | 13 |
to the induction of | 13 |
be taken into account | 13 |
production of reactive oxygen | 13 |
was not detected in | 13 |
in a decrease in | 13 |
pmcs in response to | 13 |
to determine the role | 13 |
have been described in | 13 |
a broad spectrum of | 13 |
with a diagnosis of | 13 |
significant reduction in the | 13 |
of the proinflammatory cytokines | 13 |
as measured by the | 13 |
and the incidence of | 13 |
has been reported in | 13 |
treatment of septic shock | 13 |
considered to be the | 13 |
we found that in | 13 |
patients admitted to a | 13 |
production of nitric oxide | 13 |
and h after the | 13 |
the primary outcome was | 13 |
a dose dependent manner | 13 |
by the administration of | 13 |
in combination with a | 13 |
to be the most | 13 |
differences between the groups | 13 |
with the number of | 13 |
for the activation of | 13 |
in cd t cells | 13 |
analysis was performed by | 13 |
significantly higher levels of | 13 |
t and b cells | 13 |
there was no effect | 13 |
is in line with | 13 |
in both groups of | 13 |
were associated with the | 13 |
in the culture medium | 13 |
to be expressed in | 13 |
in a significant increase | 13 |
the development of ali | 13 |
outer membrane of gram | 13 |
patients undergoing cardiac surgery | 13 |
in the lung tissue | 13 |
than that of the | 13 |
compared with that in | 13 |
and its role in | 13 |
as an inhibitor of | 13 |
at all time points | 13 |
in the icu and | 13 |
inflammatory responses in the | 13 |
in order to study | 13 |
in chronic obstructive pulmonary | 13 |
was also observed in | 13 |
and embedded in paraffin | 13 |
up to h after | 13 |
could be used to | 13 |
has previously been shown | 13 |
of the outer membrane | 13 |
here we demonstrate that | 13 |
this is due to | 13 |
the major cause of | 13 |
as a measure of | 13 |
of the actin cytoskeleton | 13 |
to investigate the impact | 13 |
was significantly decreased in | 13 |
study was conducted in | 13 |
the induction of the | 13 |
to the plasma membrane | 13 |
was to analyze the | 13 |
could be involved in | 13 |
may be a promising | 13 |
was extracted from the | 13 |
levels were measured using | 13 |
no differences in the | 13 |
for the regulation of | 13 |
mitogen activated protein kinase | 13 |
may be an important | 13 |
of patients with sepsis | 13 |
intensive care unit of | 13 |
on the one hand | 13 |
such as tumor necrosis | 13 |
cd t cells from | 13 |
studied the effect of | 13 |
are expressed as the | 13 |
cells of the immune | 13 |
were significantly decreased in | 13 |
findings suggest that the | 13 |
did not show a | 13 |
mean age was years | 13 |
is dependent on the | 13 |
with the occurrence of | 13 |
models of acute lung | 13 |
we have analyzed the | 13 |
differences were observed in | 13 |
were significantly higher than | 13 |
the data indicate that | 13 |
with different concentrations of | 13 |
on the production of | 13 |
in patients treated with | 13 |
with acute respiratory failure | 13 |
was used to evaluate | 13 |
due to the presence | 13 |
and smooth muscle cells | 13 |
critically ill patients is | 13 |
is consistent with the | 13 |
the host immune response | 13 |
turned out to be | 13 |
evaluate the role of | 13 |
it was possible to | 13 |
human pulmonary microvascular endothelial | 13 |
is due to a | 13 |
found to be significantly | 13 |
and a specificity of | 13 |
study the effect of | 13 |
women with and without | 13 |
the pei and pei | 13 |
prevention and treatment of | 13 |
induce the expression of | 13 |
with a median age | 13 |
we are currently investigating | 13 |
determined by western blot | 13 |
examined the role of | 13 |
the role of these | 13 |
analyses were performed using | 13 |
on the first day | 13 |
in c bl mice | 13 |
by the fact that | 13 |
a significant difference in | 13 |
stay in the icu | 13 |
used to evaluate the | 12 |
in the release of | 12 |
has been shown in | 12 |
in order to assess | 12 |
to the lps group | 12 |
molecular mechanisms involved in | 12 |
have the ability to | 12 |
of the menstrual cycle | 12 |
for at least h | 12 |
and this effect was | 12 |
may serve as a | 12 |
and the occurrence of | 12 |
has been demonstrated that | 12 |
is an important mediator | 12 |
in both wt and | 12 |
investigated the influence of | 12 |
simplified acute physiology score | 12 |
at different stages of | 12 |
in wild type mice | 12 |
increased the expression of | 12 |
median age of years | 12 |
cell types in the | 12 |
expression was measured by | 12 |
for a long time | 12 |
and h after lps | 12 |
due to the fact | 12 |
further studies are required | 12 |
did not change significantly | 12 |
be considered as a | 12 |
gene expression in the | 12 |
the application of the | 12 |
the identification of the | 12 |
in the percentage of | 12 |
of the dorsal funiculus | 12 |
experiments were carried out | 12 |
neutrophil recruitment to the | 12 |
glial fibrillary acidic protein | 12 |
was significantly reduced by | 12 |
nuclear factor kappa b | 12 |
arterial and mixed venous | 12 |
with that in the | 12 |
at the start of | 12 |
and tumour necrosis factor | 12 |
analyzed by flow cytometry | 12 |
and is involved in | 12 |
on the activation of | 12 |
as an internal control | 12 |
was associated with increased | 12 |
to a variety of | 12 |
the treatment of septic | 12 |
was higher in patients | 12 |
patients were treated with | 12 |
in the plasma membrane | 12 |
in the mouse lung | 12 |
presence and absence of | 12 |
of this study were | 12 |
with a variety of | 12 |
the lipid peroxide levels | 12 |
is related to the | 12 |
was to study the | 12 |
was added to each | 12 |
to be a major | 12 |
natural science foundation of | 12 |
and protein expression of | 12 |
despite the fact that | 12 |
physiology and chronic health | 12 |
have no competing interests | 12 |
can be used for | 12 |
the development of acute | 12 |
no statistically significant difference | 12 |
lower than in the | 12 |
inhibited the production of | 12 |
the patients in the | 12 |
for the presence of | 12 |
was a significant increase | 12 |
the development of sepsis | 12 |
were subjected to a | 12 |
patients were randomized to | 12 |
used to study the | 12 |
and use committee of | 12 |
a major component of | 12 |
was to describe the | 12 |
the in vivo situation | 12 |
of three independent experiments | 12 |
this was associated with | 12 |
has been studied in | 12 |
the important role of | 12 |
not significantly different from | 12 |
at g for min | 12 |
between innate and adaptive | 12 |
for h and then | 12 |
was carried out by | 12 |
was found that the | 12 |
in utero meconium passage | 12 |
and chronic health evaluation | 12 |
as well as other | 12 |
of the coagulation cascade | 12 |
in human endothelial cells | 12 |
no correlation between the | 12 |
fluorescence resonance energy transfer | 12 |
in the incidence of | 12 |
a change in the | 12 |
the absence of the | 12 |
at rpm for min | 12 |
recent evidence suggests that | 12 |
c h hej mice | 12 |
as well as on | 12 |
the production of no | 12 |
pellets were resuspended in | 12 |
is characterized by the | 12 |
mean arterial blood pressure | 12 |
to evaluate the efficacy | 12 |
to acute lung injury | 12 |
the implementation of the | 12 |
results of our study | 12 |
significantly different between the | 12 |
were incubated for h | 12 |
is a hallmark of | 12 |
changes in the expression | 12 |
was based on the | 12 |
in addition to their | 12 |
as well as their | 12 |
for each of the | 12 |
the hypothesis that the | 12 |
probably due to the | 12 |
it is believed that | 12 |
was similar in both | 12 |
cells were seeded in | 12 |
cxcr and cd l | 12 |
to the degree of | 12 |
a significant difference between | 12 |
at a rate of | 12 |
were used as controls | 12 |
and quality of life | 12 |
are associated with increased | 12 |
of influenza a virus | 12 |
of renal replacement therapy | 12 |
is likely to be | 12 |
was higher than in | 12 |
the inflammatory response to | 12 |
male wistar rats were | 12 |
the regulation of cell | 12 |
during the icu stay | 12 |
the absence of a | 12 |
after the introduction of | 12 |
were determined by elisa | 12 |
ultrasound stimulation of the | 12 |
as well as il | 12 |
aim was to investigate | 12 |
the release of pro | 12 |
order to evaluate the | 12 |
the two groups were | 12 |
guide for the care | 12 |
an important role for | 12 |
of the plasma membrane | 12 |
patients admitted in the | 12 |
a useful tool for | 12 |
for the use of | 12 |
incubated for h at | 12 |
in the brain and | 12 |
and may contribute to | 12 |
with severe head injury | 12 |
to the lack of | 12 |
order to investigate the | 12 |
in our intensive care | 12 |
patients at risk for | 12 |
to be regulated by | 12 |
a period of months | 12 |
to infiltrate into islets | 12 |
at the age of | 12 |
of the patients was | 12 |
in an intensive care | 12 |
number of patients with | 12 |
the present study demonstrated | 12 |
we and others have | 12 |
mice with and without | 12 |
acute physiology and chronic | 12 |
of stay in icu | 12 |
cells in vitro and | 12 |
the liver and spleen | 12 |
of the control group | 12 |
and reactive oxygen species | 12 |
the increase in the | 12 |
cd and cd cells | 12 |
of the complement system | 12 |
sections were incubated with | 12 |
in vitro effects of | 12 |
and mixed venous blood | 12 |
then stimulated with lps | 12 |
a high level of | 12 |
were treated with lps | 12 |
dna double strand breaks | 12 |
to examine the effects | 12 |
in the innate immune | 12 |
study we examined the | 12 |
show for the first | 12 |
was more pronounced in | 12 |
in the last years | 12 |
a potential therapeutic target | 12 |
increase in the expression | 12 |
define the role of | 12 |
were found in the | 12 |
the spinal cord of | 12 |
the lipid a moiety | 12 |
is closely related to | 12 |
the magnitude of the | 12 |
was not observed in | 12 |
for at least hours | 12 |
management of severe sepsis | 12 |
with lps and poly | 12 |
has also been shown | 12 |
epithelial and endothelial cells | 12 |
the possible role of | 12 |
can be considered as | 12 |
cells to infiltrate into | 12 |
blood samples were drawn | 12 |
we focused on the | 12 |
the cell surface and | 12 |
our findings show that | 12 |
cells were stained with | 12 |
the expression level of | 12 |
an experimental model of | 12 |
it is assumed that | 11 |
the result of the | 11 |
is known to induce | 11 |
over a month period | 11 |
the results of our | 11 |
from the bone marrow | 11 |
middle cerebral artery occlusion | 11 |
involved in this process | 11 |
compared to those in | 11 |
time pcr and western | 11 |
human peripheral blood mononuclear | 11 |
significantly reduced in the | 11 |
the following parameters were | 11 |
by cecal ligation and | 11 |
area under the receiver | 11 |
was performed with a | 11 |
the survival rate of | 11 |
the incidence of the | 11 |
levels were higher in | 11 |
may be caused by | 11 |
this study investigated the | 11 |
the mechanisms underlying the | 11 |
to play a major | 11 |
the start of the | 11 |
and their ability to | 11 |
and the outcome of | 11 |
did not change the | 11 |
levels of tumor necrosis | 11 |
immune and inflammatory responses | 11 |
were determined by western | 11 |
to be able to | 11 |
on the activity of | 11 |
and sitagliptin lps group | 11 |
can be induced by | 11 |
the expression of adhesion | 11 |
sought to determine the | 11 |
an important regulator of | 11 |
explore the role of | 11 |
through the use of | 11 |
b f melanoma cells | 11 |
inflammatory cells in the | 11 |
and a decrease in | 11 |
of cells in the | 11 |
to be increased in | 11 |
oxidative stress and inflammation | 11 |
for the maintenance of | 11 |
were identified in the | 11 |
we have previously reported | 11 |
membranes were incubated with | 11 |
also involved in the | 11 |
in the brain of | 11 |
was carried out on | 11 |
by grants from the | 11 |
the nuclear translocation of | 11 |
acute lung injury induced | 11 |
is not sufficient to | 11 |
in the amount of | 11 |
approved by the animal | 11 |
to be present in | 11 |
in this animal model | 11 |
end of the study | 11 |
there was an increase | 11 |
were used to identify | 11 |
was the most common | 11 |
be associated with a | 11 |
highly expressed in the | 11 |
which is involved in | 11 |
can be activated by | 11 |
has been proposed that | 11 |
is a major cause | 11 |
in order to reduce | 11 |
associated with high mortality | 11 |
is necessary for the | 11 |
is not clear whether | 11 |
have been reported in | 11 |
caused an increase in | 11 |
we observed a significant | 11 |
the percentage of cd | 11 |
of intensive care unit | 11 |
animals were sacrificed and | 11 |
which is known to | 11 |
the position of the | 11 |
male c bl mice | 11 |
the introduction of the | 11 |
that in addition to | 11 |
no difference between the | 11 |
of activin a in | 11 |
the molecular mechanisms involved | 11 |
enrolled in the study | 11 |
leads to the activation | 11 |
resulted in a decrease | 11 |
in the development and | 11 |
can be used in | 11 |
this study we have | 11 |
the accuracy of the | 11 |
university medical center groningen | 11 |
were used as control | 11 |
in a state of | 11 |
to be essential for | 11 |
in an increase in | 11 |
that the number of | 11 |
were no statistically significant | 11 |
levels of proinflammatory cytokines | 11 |
were significantly elevated in | 11 |
the plasma levels of | 11 |
and length of stay | 11 |
important roles in the | 11 |
understand the role of | 11 |
pulmonary surfactant protein sp | 11 |
an increased expression of | 11 |
leads to activation of | 11 |
to investigate whether the | 11 |
the pathogenesis of sepsis | 11 |
cells in the lung | 11 |
there was also a | 11 |
to act as a | 11 |
in the early stage | 11 |
is associated with high | 11 |
was used for the | 11 |
the presence of lps | 11 |
fatty acid and pl | 11 |
in comparison to control | 11 |
activation of the nlrp | 11 |
of patients were included | 11 |
for critically ill patients | 11 |
of protein kinase c | 11 |
levels were significantly increased | 11 |
in the face of | 11 |
at day after the | 11 |
is the most important | 11 |
total body surface area | 11 |
taking into account the | 11 |
was followed by a | 11 |
plays an essential role | 11 |
has not been reported | 11 |
in order to achieve | 11 |
examined the effects of | 11 |
is a risk factor | 11 |
is not due to | 11 |
contribute to the pathogenesis | 11 |
the efficacy and safety | 11 |
to reduce the incidence | 11 |
we can conclude that | 11 |
plates at a density | 11 |
of pulmonary surfactant protein | 11 |
between january and december | 11 |
in patients suffering from | 11 |
to determine the expression | 11 |
the pathophysiology of sepsis | 11 |
as an index of | 11 |
these results indicated that | 11 |
significantly higher than those | 11 |
significantly higher in patients | 11 |
male c bl j | 11 |
was determined using a | 11 |
centrifuged at rpm for | 11 |
protein expression in the | 11 |
we have studied the | 11 |
no differences were observed | 11 |
independent risk factor for | 11 |
has been observed in | 11 |
could be due to | 11 |
differences were found in | 11 |
on the effects of | 11 |
multiple organ failure in | 11 |
in the study group | 11 |
may be mediated by | 11 |
of the patients in | 11 |
a broad range of | 11 |
on the use of | 11 |
on admission to the | 11 |
in a previous study | 11 |
the promoter region of | 11 |
for a total of | 11 |
a prospective cohort study | 11 |
stimulation of the spleen | 11 |
less is known about | 11 |
age of the patients | 11 |
and the formation of | 11 |
to evaluate the impact | 11 |
there were no statistically | 11 |
for the indicated time | 11 |
is highly expressed in | 11 |
on the inflammatory response | 11 |
of patients treated with | 11 |
regulate the expression of | 11 |
with acute liver failure | 11 |
a consequence of the | 11 |
between survivors and non | 11 |
was measured using the | 11 |
and the production of | 11 |
thought to play a | 11 |
is the first report | 11 |
for at least days | 11 |
two groups of patients | 11 |
no significant difference was | 11 |
of hla class i | 11 |
of cd t cell | 11 |
has been related to | 11 |
under the receiver operating | 11 |
a flow rate of | 11 |
oxidative stress in the | 11 |
the beneficial effect of | 11 |
in an effort to | 11 |
have been proposed to | 11 |
as described in the | 11 |
evaluate the efficacy of | 11 |
of the extracellular matrix | 11 |
is accompanied by a | 11 |
was observed in patients | 11 |
sought to determine whether | 11 |
have also shown that | 11 |
statistically significant differences between | 11 |
sepsis and multiple organ | 11 |
arterial partial pressure of | 11 |
the role of il | 11 |
both groups of patients | 11 |
in mouse models of | 11 |
when compared to non | 11 |
crucial role in the | 11 |
during the process of | 11 |
as indicated by the | 11 |
and water ad libitum | 11 |
of the activation of | 11 |
in innate and adaptive | 11 |
we hypothesize that the | 11 |
cellular and molecular mechanisms | 11 |
type c bl mice | 11 |
response to lps stimulation | 11 |
the pathogenesis of ards | 11 |
for the initiation of | 11 |
is associated with significant | 11 |
was to determine if | 11 |
in the white matter | 11 |
production of inflammatory mediators | 11 |
of the adaptive immune | 11 |
a high fat diet | 11 |
and apache ii score | 11 |
within the first h | 11 |
critically ill patients and | 11 |
at the protein level | 11 |
the presence and absence | 11 |
levels were significantly higher | 11 |
used in the treatment | 11 |
in group a and | 11 |
involved in regulation of | 11 |
may be a useful | 11 |
from peripheral blood of | 11 |
have not yet been | 11 |
in the amygdala and | 11 |
the contribution of the | 11 |
challenged ttp are mice | 11 |
on day of gestation | 11 |
was identified as a | 11 |
cells in the lungs | 11 |
the secretion of il | 11 |
that the majority of | 11 |
the present study showed | 11 |
a p value of | 11 |
in the use of | 11 |
mice were challenged with | 11 |
pcr and western blotting | 11 |
been shown to inhibit | 11 |
of the effect of | 11 |
group compared with the | 11 |
study was conducted to | 11 |
to assess the impact | 11 |
present study demonstrated that | 11 |
none of the patients | 11 |
h after lps injection | 11 |
expression and activity of | 11 |
we previously showed that | 11 |
and then incubated with | 11 |
the underlying mechanism of | 11 |
of porcine reproductive and | 11 |
expression was determined by | 11 |
smooth muscle cells of | 11 |
institutional animal care and | 11 |
in the brains of | 11 |
due to the lack | 11 |
the outcome of the | 10 |
fold increase in the | 10 |
been shown to improve | 10 |
resulted in an increase | 10 |
in presence or absence | 10 |
vascular cell adhesion molecule | 10 |
a portion of the | 10 |
and the need for | 10 |
the lungs of mice | 10 |
and incubated for h | 10 |
were not affected by | 10 |
that the induction of | 10 |
time pcr was performed | 10 |
but had no effect | 10 |
to a lack of | 10 |
the best of our | 10 |
in intensive care patients | 10 |
a leading cause of | 10 |
the time of admission | 10 |
results are shown in | 10 |
respiratory distress syndrome in | 10 |
significantly lower than in | 10 |
rats were subjected to | 10 |
the onset of labour | 10 |
partial pressure of oxygen | 10 |
significantly decreased in the | 10 |
been related to the | 10 |
of severe sepsis in | 10 |
they have no competing | 10 |
this effect was not | 10 |
the peripheral nervous system | 10 |
were washed three times | 10 |
showed a significant decrease | 10 |
high performance liquid chromatography | 10 |
found in patients with | 10 |
suggest a role for | 10 |
such as multiple sclerosis | 10 |
in septic shock patients | 10 |
by western blotting and | 10 |
organ failure and death | 10 |
of the respiratory system | 10 |
expression of tlr and | 10 |
compared to the non | 10 |
the aims of this | 10 |
rats were divided into | 10 |
the rest of the | 10 |
have also been shown | 10 |
it is associated with | 10 |
the adaptive immune system | 10 |
play a significant role | 10 |
previously been shown to | 10 |
in severe sepsis and | 10 |
the development of onfh | 10 |
data were obtained from | 10 |
were considered to be | 10 |
in the ca region | 10 |
of central nervous system | 10 |
included in the analysis | 10 |
the upper and lower | 10 |
revealed the presence of | 10 |
in patients with or | 10 |
the changes in the | 10 |
the indicated time periods | 10 |
there is a growing | 10 |
and mean arterial pressure | 10 |
after the start of | 10 |
in experimental models of | 10 |
one of the following | 10 |
to evaluate the incidence | 10 |
been shown that the | 10 |
for the determination of | 10 |
be important in the | 10 |
supported by the dfg | 10 |
the development of new | 10 |
extract from folium isatidis | 10 |
effect of ginsenoside rb | 10 |
that is associated with | 10 |
on the effect of | 10 |
innate and adaptive its | 10 |
into the role of | 10 |
to the expression of | 10 |
the characteristics of the | 10 |
lung injury in rats | 10 |
lung tissues were harvested | 10 |
as a regulator of | 10 |
gd t cells in | 10 |
the mortality rate of | 10 |
with the aim of | 10 |
differences between groups were | 10 |
group and in the | 10 |
in a cohort of | 10 |
would like to thank | 10 |
in the diagnosis of | 10 |
at a final concentration | 10 |
and are involved in | 10 |
a growing body of | 10 |
for a number of | 10 |
was measured at nm | 10 |
levels were measured in | 10 |
of patients in the | 10 |
of oxidative stress and | 10 |
in spite of the | 10 |
growing body of evidence | 10 |
the response of the | 10 |
order to study the | 10 |
for more than h | 10 |
patients with or without | 10 |
a positive effect on | 10 |
differences in the expression | 10 |
over a year period | 10 |
were carried out in | 10 |
the absence of il | 10 |
a variety of cells | 10 |
the prevention and treatment | 10 |
during the first week | 10 |
patients with acute renal | 10 |
and contributes to the | 10 |
were excluded from the | 10 |
within the dorsal funiculus | 10 |
study the role of | 10 |
with sepsis and septic | 10 |
was determined by western | 10 |
the acute inflammatory response | 10 |
in both cell lines | 10 |
aim of this project | 10 |
with increased risk of | 10 |
time polymerase chain reaction | 10 |
as well as of | 10 |
measured before and after | 10 |
induced activation of the | 10 |
a period of years | 10 |
recent studies have shown | 10 |
after the injection of | 10 |
in the placebo group | 10 |
in the placenta and | 10 |
by a decrease in | 10 |
the interaction between the | 10 |
have been linked to | 10 |
the mode of action | 10 |
in the hippocampus of | 10 |
exacerbations of chronic obstructive | 10 |
detected in the lungs | 10 |
lower in patients with | 10 |
the difference between the | 10 |
mice were purchased from | 10 |
butanol extract from folium | 10 |
left ventricular ejection fraction | 10 |
support the hypothesis that | 10 |
and septic shock in | 10 |
the structure of the | 10 |
used to examine the | 10 |
could be detected in | 10 |
we have identified a | 10 |
a pulmonary artery catheter | 10 |
of patients who were | 10 |
a slight increase in | 10 |
leading cause of death | 10 |
these findings indicate that | 10 |
as compared to wt | 10 |
anesthesia and intensive care | 10 |
changes were observed in | 10 |
the correlation between the | 10 |
to the best of | 10 |
our goal was to | 10 |
we investigated the impact | 10 |
have the potential to | 10 |
the frequency of the | 10 |
in a significant reduction | 10 |
to be a promising | 10 |
the objective of the | 10 |
of microglia and astrocytes | 10 |
even in the absence | 10 |
the role of cd | 10 |
treatment of severe sepsis | 10 |
the incidence of vap | 10 |
the injection of lps | 10 |
to be due to | 10 |
best of our knowledge | 10 |
the length of icu | 10 |
a potential target for | 10 |
the need for a | 10 |
have been used to | 10 |
that are involved in | 10 |
the expression of several | 10 |
the fact that the | 10 |
support the concept that | 10 |
similar to that observed | 10 |
the cellular response to | 10 |
to determine if the | 10 |
observed in patients with | 10 |
of surfactant protein a | 10 |
patients of group a | 10 |
the number of total | 10 |
national natural science foundation | 10 |
were not different between | 10 |
in our study we | 10 |
was collected from the | 10 |
virus and or lps | 10 |
be due to a | 10 |
are presented as the | 10 |
be the result of | 10 |
the molecular basis of | 10 |
and to assess the | 10 |
here we investigated the | 10 |
the functionality of the | 10 |
klinische pharmakologie und toxikologie | 10 |
centrifuged at g for | 10 |
outcome in patients with | 10 |
the surviving sepsis campaign | 10 |
one of the key | 10 |
science foundation of china | 10 |
mean pulmonary artery pressure | 10 |
activated partial thromboplastin time | 10 |
a key factor in | 10 |
it was observed that | 10 |
expression is increased in | 10 |
significantly lower in patients | 10 |
there is evidence that | 10 |
of vascular smooth muscle | 10 |
in the prevention of | 10 |
the immune system and | 10 |
has been extensively studied | 10 |
blood of patients with | 10 |
findings of this study | 10 |
to the cell surface | 10 |
through the inhibition of | 10 |
in the presence and | 10 |
in mice treated with | 10 |
over the study period | 10 |
the findings of this | 10 |
were extracted from the | 10 |
the goal of the | 10 |
patients with chronic obstructive | 10 |
of high mobility group | 10 |
using an in vitro | 10 |
formation of reactive oxygen | 10 |
and at the end | 10 |
to evaluate the role | 10 |
the number of cd | 10 |
significantly higher than the | 10 |
weaning from mechanical ventilation | 10 |
the clinical course of | 10 |
male balb c mice | 10 |
model of acute lung | 10 |
that in the lps | 10 |
should be considered in | 10 |
of the intestinal mucosa | 10 |
and the rate of | 10 |
under the influence of | 10 |
of s a and | 10 |
the location of the | 10 |
the effect of this | 10 |
had at least one | 10 |
in a prospective study | 10 |
in the gastrointestinal tract | 10 |
have recently demonstrated that | 10 |
was significantly greater in | 10 |
was performed with the | 10 |
of the spinal cord | 10 |
the release of il | 10 |
of the p x | 10 |
have been used in | 10 |
und klinische pharmakologie und | 10 |
proinflammatory cytokines such as | 10 |
by the innate immune | 10 |
has been described as | 10 |
were washed with pbs | 10 |
the severity of sepsis | 10 |
demonstrate for the first | 10 |
statistical analysis was done | 10 |
and stimulated with lps | 10 |
studies have indicated that | 10 |
death in patients with | 10 |
to explore the role | 10 |
and mortality in patients | 10 |
the context of the | 10 |
the introduction of a | 10 |
to interfere with the | 10 |
a beneficial effect on | 10 |
we sought to identify | 10 |
used for the treatment | 10 |
a key regulator of | 10 |
is not involved in | 10 |
the patients with severe | 10 |
induced by lipopolysaccharide in | 10 |
to be mediated by | 10 |
be part of the | 10 |
within the normal range | 10 |
to the inhibition of | 10 |
gene expression in human | 10 |
in some of the | 10 |
outcomes in patients with | 10 |
prevent the development of | 10 |
of stay in the | 10 |
such as rheumatoid arthritis | 10 |
in combination with the | 10 |
for the measurement of | 10 |
due to differences in | 10 |
the most commonly used | 10 |
at various time points | 10 |
showed a significant reduction | 10 |
the predictive value of | 10 |
we have developed an | 10 |
other members of the | 10 |
to study the role | 10 |
that the effect of | 10 |
for the purpose of | 10 |
increases the risk of | 10 |
the early postoperative period | 10 |
cells were cultured for | 10 |
we would like to | 10 |
severity of the disease | 10 |
to a reduction of | 10 |
the data suggest that | 10 |
and function of the | 10 |
will be used to | 10 |
study was to establish | 10 |
on the type of | 10 |
for the production of | 10 |
serum of patients with | 10 |
on cd t cells | 10 |
this study was designed | 10 |
we examined the role | 10 |
found to inhibit the | 10 |
to its ability to | 10 |
inflammatory cytokines in the | 10 |
in the supernatant of | 10 |
we showed that the | 10 |
not differ significantly between | 10 |
for patients with severe | 10 |
the functional relevance of | 10 |
by the expression of | 10 |
study is to assess | 10 |
or a combination of | 10 |
been suggested to be | 10 |
aims of this study | 10 |
and to evaluate the | 10 |
their role in the | 10 |
the strength of the | 10 |
are required for the | 10 |
a high incidence of | 10 |
were used for statistical | 10 |
in the recognition of | 10 |
suggesting a role for | 10 |
among the three groups | 10 |
this study we examined | 10 |
brain microvascular endothelial cells | 10 |
with a combination of | 10 |
experimentelle und klinische pharmakologie | 10 |
with the hp group | 10 |
for the formation of | 10 |
of effector t cells | 10 |
the lung injury score | 10 |
to that of the | 10 |
which was associated with | 10 |
the aim was to | 10 |
in one of the | 10 |
in an in vivo | 10 |
room temperature for h | 10 |
caused a significant increase | 10 |
in mice challenged with | 10 |
shown to interact with | 9 |
were admitted to icu | 9 |
in the respiratory tract | 9 |
expression levels of the | 9 |
t cells to infiltrate | 9 |
the length of the | 9 |
factor in the pathogenesis | 9 |
shown in the table | 9 |
the physiological function of | 9 |
considered to be a | 9 |
phase of influenza infection | 9 |
with ng ml lps | 9 |
induced ards mice and | 9 |
the expression and function | 9 |
regulating the expression of | 9 |
rna was isolated from | 9 |
and the cells were | 9 |
not differ between the | 9 |
of mhc class i | 9 |
coronary artery bypass graft | 9 |
we prospectively studied patients | 9 |
significantly elevated in the | 9 |
the site of infection | 9 |
expression was significantly increased | 9 |
were found to have | 9 |
injury and acute respiratory | 9 |
prior to icu admission | 9 |
immune response in the | 9 |
as shown in table | 9 |
a variety of different | 9 |
evaluated the ability of | 9 |
at the mrna level | 9 |
may account for the | 9 |
of vascular endothelial growth | 9 |
single cell suspensions were | 9 |
are associated with the | 9 |
between the degree of | 9 |
reduced the incidence of | 9 |
was assessed in the | 9 |
associated with increased risk | 9 |
between patients with and | 9 |
was not due to | 9 |
to be independent of | 9 |
majority of patients with | 9 |
data show that the | 9 |
performed in order to | 9 |
the high level of | 9 |
to define the role | 9 |
surfactant proteins a and | 9 |
to investigate the potential | 9 |
results showed that lps | 9 |
t cell proliferation and | 9 |
in mouse and human | 9 |
of gene expression in | 9 |
found to be a | 9 |
is to assess the | 9 |
the treatment of the | 9 |
lipid peroxide levels and | 9 |
patients in intensive care | 9 |
role of nitric oxide | 9 |
risk factors associated with | 9 |
used in combination with | 9 |
does not appear to | 9 |
an increased incidence of | 9 |
we have evaluated the | 9 |
within the first days | 9 |
is critical for the | 9 |
positive cells in the | 9 |
from the peripheral blood | 9 |
study was to characterize | 9 |
as assessed by the | 9 |
increased the production of | 9 |
as a therapeutic target | 9 |
analyzed the effect of | 9 |
of the t cell | 9 |
the release of proinflammatory | 9 |
study demonstrates that the | 9 |
was carried out using | 9 |
guidelines for management of | 9 |
patients with severe acute | 9 |
to the emergency department | 9 |
have been described to | 9 |
patients with chronic liver | 9 |
maternal and fetal plasma | 9 |
from santa cruz biotechnology | 9 |
as in the case | 9 |
the specificity of the | 9 |
the deleterious effects of | 9 |
is regulated by the | 9 |
neutral with regard to | 9 |
we propose that the | 9 |
hours after lps injection | 9 |
and the induction of | 9 |
in a subset of | 9 |
study has shown that | 9 |
sought to determine if | 9 |
the combination of the | 9 |
of bacteria in the | 9 |
which are associated with | 9 |
used to investigate the | 9 |
informed consent was obtained | 9 |
of the fatty acid | 9 |
a statistically significant difference | 9 |
associated with changes in | 9 |
was a trend towards | 9 |
with or without lps | 9 |
do not appear to | 9 |
with the increase in | 9 |
with that of the | 9 |
during the first trimester | 9 |
is to investigate the | 9 |
our study suggests that | 9 |
in the fetal brain | 9 |
to the ability of | 9 |
no differences were found | 9 |
divided in two groups | 9 |
compared to wildtype mice | 9 |
different time points after | 9 |
was not different between | 9 |
in the rate of | 9 |
admitted to intensive care | 9 |
acid and pl synthesis | 9 |
data agreed with those | 9 |
purpose of the present | 9 |
for their ability to | 9 |
into the peritoneal cavity | 9 |