This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-003055-88q36g00 | Developmental neuroinflammation and schizophrenia Schizophrenia and autism: both shared and disorder- specific pathogenesis via perinatal inflammation? |
| cord-000460-h3owwjao | Chlamydia pneumoniae binds to platelets and triggers P- selectin expression and aggregation: a causal role in cardiovascular disease? |
| cord-007178-h0ordzm9 | Could the current observations on LPS- induced demyelination illuminate the mechanisms involved in the demyelination observed in inflammatory demyelinating disease? |
| cord-006700-df8ard9o | Complete resolution of life- threatening bleomycin- induced pneumonitis after treatment with imatinib mesylate in a patient with Hodgkin's lymphoma: hope for severe chemotherapy- induced toxicity? |
| cord-000959-nk2thkme | The aging of early B- cell precursors Aging of the immune system: how much can the adaptive immune system adapt? |
| cord-103496-8tq78p2z | Acute respiratory failure in COVID-19: is it"typical"ARDS? |
| cord-006605-tsk3pakb | -kB Role of proteaseactivated receptors in airway function: a target for therapeutic intervention? |
| cord-103592-lkngp2u6 | The mercurial nature of neutrophils: still an enigma in ARDS? |
| cord-255578-0ltb9dpa | Is the complement activation product C3a a proinflammatory molecule? |
| cord-006279-ib5z3elq | Oxygenative cleavage requiring cytochrome P-450 Renal ischemia/ reperfusion up- regulates heme oxygenase-1( HSP32) expression and increases cGMP in rat heart Role of endothelial carbon monoxide in attenuated vasoreactivity following chronic hypoxia Carbon monoxide and cerebral microvascular tone in newborn pigs Inhibitory effect of CO on internal anal sphincter: Heme oxygenase inhibitor inhibits NANC relaxation Carbon monoxide as an endogenous modulator of hepatic vascular perfusion Heme oxygenase- carbon monoxide signalling pathway in atherosclerosis: Anti- atherogenic actions of bilirubin and carbon monoxide? |
| cord-294193-xjq9j2gv | O Role of intestinal mucins in innate host defense mechanisms against pathogens Getting a grip on things: how do communities of bacterial symbionts become established in our intestine? |
| cord-310535-ay2cdf2w | kappa B inflammatory bowel disease Selective inhibitors of inducible nitric oxide synthase: potential agents for the treatment of inflammatory diseases? |
| cord-311481-2awvmpyh | New cures sought from old drugs Drug repurposing in chemical genomics: can we learn from the past to improve the future? |
| cord-331887-kagggou1 | Can 486 Chinese Medicine Be Used for Prevention of Corona Virus Disease 2019( COVID-19)? |
| cord-322729-47c9z2gk | The cross- talk between dendritic and regulatory T cells: good or evil? |
| cord-270213-ygb64yxc | do we stand? |
| cord-351310-6p42b144 | What's new? |
| cord-329274-ncvvmkca | interferon- a, tumor necrosis factor- a, interleukin-1 and inflammation during acute influenza in pigs: a possible model for humans? |
| cord-000137-idffrnac | How does HS- activated PMN enhance TLR4 upregulation of TLR2 in AMφ? |
| cord-000137-idffrnac | The acute respiratory distress syndrome Epithelial cell apoptosis and neutrophil recruitment in acute lung injury- a unifying hypothesis? |
| cord-351730-qmbo1dmo | The role of lipid peroxidation in endotoxin- induced hepatic damage and the protective effect of antioxidants Total oligomeric flavonoids of Cyperus rotundus ameliorates neurological deficits, excitotoxicity and behavioral alterations induced by cerebral ischemic- reperfusion injury in rats Cyclooxygenase-2 inhibition improves vascular endothelial dysfunction in a rat model of endotoxic shock: role of inducible nitricoxide synthase and oxidative stress Flavonoids: antioxidants or signalling molecules? |
| cord-261367-i1n8x0uc | Lymphoid follicles in( very) severe COPD: beneficial or harmful? |
| cord-000425-isw6jeir | ( TIF) Estimation of genetic trends in French Large White pigs from 1977 to 1998 for growth and carcass traits using frozen semen Selection for high immune response: an alternative approach to animal health maintenance? |
| cord-000425-isw6jeir | function QTL for traits related to humoral immune response estimated from data of a porcine F2 resource population Mapping quantitative trait loci for cytokines in the pig Deciphering the genetic control of innate and adaptive immune responses in pig: a combined genetic and genomic study Markers to measure immunomodulation in human nutrition intervention studies Immunological parameters: what do they mean? |
| cord-292862-ezrkg0dc | The 2016 ATS bear cage award- winning proposal The mercurial nature of neutrophils: still an enigma in ARDS? |
| cord-292862-ezrkg0dc | The multifaceted functions of neutrophils Neutrophils in the activation and regulation of innate and adaptive immunity What drives neutrophils to the alveoli in ARDS? |
| cord-030385-btf502ju | Biomarkers of sepsis Two decades of mortality trends among patients with severe sepsis: a comparative meta- analysis Incidence and trends of sepsis in US hospitals using clinical vs claims data Biomarker cruises in sepsis: who is the CAPTAIN? |
| cord-030385-btf502ju | catabolism syndrome Penkid: a novel biomarker of reduced GFR in sepsis Adaptation of a biomarker- based sepsis mortality risk stratification tool for pediatric acute respiratory distress syndrome Reconsidering lactate as a sepsis risk biomarker Gender differences in sepsis: genetically determined? |
| cord-349201-d88g5toc | The spleen: the forgotten organ in acute kidney injury of critical illness Splenectomy exacerbates lung injury after ischemic acute kidney injury in mice Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? |
| cord-306577-gq6fss5l | A relation between localization and function? |
| cord-306577-gq6fss5l | Necrotizing enterocolitis in very low birth weight infants: biodemographic and clinical correlates Very low birth weight outcomes of the National Institute of Child Health and Human Development neonatal network Necrotizing enterocolitis- multisystem organ failure of the newborn? |
| cord-012791-dyk5mr1q | Elevated CNS inflammation in patients with preclinical Alzheimer's disease Is'friendly fire'in the brain provoking Alzheimer's disease? |
| cord-012791-dyk5mr1q | Stimulating astrocytes to remember Does rapid and physiological astrocyte- neuron signalling amplify epileptic activity? |
| cord-018969-0zrnfaad | Where have all the bees gone? cord-018969-0zrnfaad What Is Causing CCD? cord-005832-p1joajvn LPS group, DEX? cord-005832-p1joajvn Mice were randomly divided into eight groups: blank control group, LPS group, gossypol( 2.5, 5, 10, 20 and 40 mg/ kg)? cord-005872-w1x1i0im Does elevated nitric oxide production enhance the release of prostacyclin from shear stressed aortic endothelial cells? cord-005872-w1x1i0im To block or enhance its production during sepsis? cord-023026-2r84ndzv Does transplantation of healthy endothelial cells have a beneficial effect on the outcome of ischemic brain damage? cord-302490-em1tiz7s Interfacial sensing by alveolar type II cells: A new concept in lung physiology? cord-302490-em1tiz7s The closer we look the more we see? cord-002411-iiw878w8 Has mortality from acute respiratory distress syndrome decreased over time? cord-002411-iiw878w8 Signaling The mercurial nature of neutrophils: still an enigma in ARDS? cord-257092-r11cgpvs How do immune cells overcome the blood- brain barrier in multiple sclerosis? cord-257092-r11cgpvs Neutralization of macrophage inflammatory protein 2( MIP-2) and MIP-1alpha attenuates neutrophil recruitment in the central nervous system during experimental bacterial meningitis Chemokines: sirens of neutrophil recruitment but is it just one song? cord-264145-73e61rlq Dysbiosis Associated with Derangements in Gut Permeability and Intestinal Cellular Homeostasis Independent of Diet Influence of a high- fat diet on gut microbiota, intestinal permeability and metabolic endotoxemia Involvement of reactive oxygen species in Toll- like receptor 4-dependent activation of NF- kappa B Metabolic endotoxemia with obesity: is it real and is it relevant? cord-264145-73e61rlq SARS- CoV-2 Spike protein binds to bacterial lypopolysaccharide and boosts proinflammatory activity Obesity- related low- grade chronic inflammation: implementation of the dietary inflammatory index in clinical practice is the milestone? cord-336432-tu00gffr Can we trust docking results? cord-336432-tu00gffr China Is it reliable to take the molecular docking top scoring position as the best solution without considering available structural data? cord-006888-qfnukav4 Is Brain Natriuretic Peptide a good marker for Obstructive Sleep Apnea and the efficacy of Continuous Positive Airway Pressure Therapy in Obstructive Sleep Apnea Patients? cord-006888-qfnukav4 The question that this project will address is; are CF neutrophils intrinsically abnormal? cord-006888-qfnukav4 [ yes/ no]? cord-346488-y7r7el4e A critical cysteine is required for HMGB1 binding to Toll- like receptor 4 and activation of macrophage cytokine release Novel signaling interactions between proteinase- activated receptor 2 and Toll- like receptors in vitro and in vivo Variations in the hemagglutinin of the 2009 H1N1 pandemic virus: potential for strains with altered virulence phenotype? cord-346488-y7r7el4e Approaching the asymptote? cord-023935-o2ffxgnn In monitoring her response to these interventions, which of the following should NOT be used as a therapeutic endpoint to monitor her progress? cord-023935-o2ffxgnn There is suffi cient data to justify the use of which of the following adjuvant therapies in pediatric sepsis? cord-023935-o2ffxgnn Which of the following components of coagulation is increased during sepsis? cord-341458-hkopopa6 Pathophysiological implications justifying antioxidant co- therapy Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox? cord-341458-hkopopa6 The enhanced permeability retention effect: A new paradigm for drug targeting in infection Free Radicals in Biology and Medicine Transport mechanisms of squalenoyl- adenosine nanoparticles across the blood- brain barrier Bench- to- bedside review: Targeting antioxidants to mitochondria in sepsis Squalene- adenosine nanoparticles: Ligands of adenosine receptors or adenosine prodrug? cord-012487-s920s5wb ( PlsB) Regulation of phospholipid synthesis in Escherichia coli by guanosine tetraphosphate Regulation of membrane phospholipid synthesis by the relA gene: dependence on ppGpp levels Effect of ppGpp on Escherichia coli cyclopropane fatty acid synthesis is mediated through the RpoS sigma factor( sigmaS) Enzymology, genetics, and regulation of membrane phospholipid synthesis in Escherichia coli Bacterial membrane lipids: where do we stand? cord-012487-s920s5wb But what controls PlsB? cord-012487-s920s5wb What might have caused the transient increase in fatty acid synthesis observed after translation inhibition? cord-354765-abayh871 Innate immune response to viral infection Mechanisms and Therapeutic Relevance of Neuro- immune Communication Acute respiratory failure in COVID-19: is ittypical"ARDS? |
| cord-354765-abayh871 | Peripheral Focused Ultrasound Stimulation( pFUS): New Competitor in Pharmaceutical Markets? |
| cord-354765-abayh871 | Revisited Storm, typhoon, cyclone or hurricane in patients with COVID-19? |
| cord-032181-gmcugd8h | : What do we really know? |
| cord-032181-gmcugd8h | The pathophysiology of trauma- induced coagulopathy Laboratory evidence of hyperfibrinolysis in association with low PAI-1 activity Interventional algorithms for the control of coagulopathic bleeding in surgical, trauma, and postpartum settings: recommendations from the Share Network Group Hyperfibrinolysis and the risk of hemorrhage in stable cirrhotic patients Does negative heparin- platelet factor 4 enzymelinked immunosorbent assay effectively exclude heparin- induced thrombocytopenia? |
| cord-032181-gmcugd8h | The role of antioxidants and zinc in minimal hepatic encephalopathy: a randomized trial Tranilast reduces serum IL-6 and IL-13 and protects against thioacetamide- induced acute liver injury and hepatic encephalopathy Is it worth removing albumin- bound substances in hepatic encephalopathy? |
| cord-252855-xtsnlu1f | A double- edged sword? |
| cord-252855-xtsnlu1f | Endocytosis and use as an iron source by the parasite Entamoeba histolytica Iron- saturated lactoferrin and pathogenic protozoa: Could this protein be an iron source for their parasitic style of life? |
| cord-252855-xtsnlu1f | The inflammatory response triggered by Influenza virus: A two edged sword The effects of corticosteroid on tissue lactoferrin in patients with nasal polyposis Global Epidemiology of Tuberculosis BCG- Different strains, different vaccines? |
| cord-022136-3q24qxsr | 12? |
| cord-022136-3q24qxsr | Is S100A8-SAA3 expression necessary and/or sufficient for premetastatic soil establishment? |
| cord-022136-3q24qxsr | What is the mechanism by which to explain the sustained expression of S100A8 and SAA3 in the lungs while their serum levels decrease 10- 14 days after implantation of tumor cells? |
| cord-022136-3q24qxsr | What will happen when endothelial cells are systemically injured? |
| cord-022252-9yiuuye3 | ( An era of new'magic bullets'?) |
| cord-022252-9yiuuye3 | Could it be that host responses to LPS are, like the complement or the clotting systems, useful in moderation but harmful in excess? |
| cord-022252-9yiuuye3 | Cytolytic pore- forming proteins and peptides: is there a common structural motif? |
| cord-022252-9yiuuye3 | How does CT work? |
| cord-022252-9yiuuye3 | What is the role played by Shiga toxin? |
| cord-252859-zir02q69 | Can gene or protein expression profiles be used to diagnose sepsis in other animal models? |
| cord-252859-zir02q69 | If so, are there predictive gene sets that are common to different types of infection( eg, gram- positive versus gram- negative infections)? |
| cord-252859-zir02q69 | Once the diagnosis has been made, are there markers that indicate response to therapy or prognosis? |
| cord-252859-zir02q69 | What are the optimal computational methods to identify robust predictors from microarray or proteomic data? |
| cord-015147-h0o0yqv8 | Here we report on the development of the PGE2 mimetic combination therapy( DP-837953) that inhibits basal and LPS/ TLR4 induced TNF-?, IL-1ß, and MMP-1, 8, 9, 13 in human and murine synovial membranes and peripheral macrophages. |
| cord-015147-h0o0yqv8 | In a murine model of chronic synovitis( dorsal skin air pouch), DP837953 dramatically inhibited IL-1ß, TNF-?, MIP2, MCP-2 and IL-8 expression, delayed the profile of leukocyte/ neutrophil extravasation and reduced exudate volume. |
| cord-015147-h0o0yqv8 | In addition, TNF-?, IL-1ß, MMP-8 and to a lesser extent MMP-9 expression/ synthesis levels were strongly suppressed as judged by RT- PCR and ELISA measurements |
| cord-015147-h0o0yqv8 | Most of the recent studies have focused on challenge- induced expression of antimicrobial peptides and have addressed the following questions:( 1) which genes are upregulated during various types of bacterial, fungal or viral infections and what are their functions? |
| cord-006318-9r51n241 | A systematic review on more than 34,000 subjects Neutrophil NETs: a novel contributor to preeclampsia- associated placental hypoxia? |
| cord-006318-9r51n241 | Activin A: a novel player and inflammatory marker in inflammatory bowel disease? |
| cord-006318-9r51n241 | The lung in sepsis: guilty or innocent? |
| cord-006318-9r51n241 | betaC and betaE genes are not essential for mouse liver growth, differentiation, and regeneration Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins Functional analysis of activins during mammalian development Beta A versus beta B: is it merely a matter of expression? |
| cord-006318-9r51n241 | key: cord-006318- 9r51n241 authors: Sideras, Paschalis; Apostolou, Eirini; Stavropoulos, Athanasios; Sountoulidis, Alexandros; Gavriil, Arianna; Apostolidou, Anastasia; Andreakos, Evangelos title: Activin, neutrophils, and inflammation: just coincidence? |
| cord-348391-xytmq2f2 | Are they closely related? |
| cord-348391-xytmq2f2 | Characteristics of pediatric SARS- CoV-2 infection and potential evidence for persistent fecal viral shedding The immunology of COVID-19: Is immune modulation an option for treatment? |
| cord-348391-xytmq2f2 | Recombination and complementation between orthomyxoviruses under conditions of abortive infection Why is the flu vaccine so mediocre? |
| cord-348391-xytmq2f2 | The mechanism of cell death during West Nile virus infection is dependent on initial infectious dose Mechanism of cell death during infectious salmon anemia virus infection is cell type- specific Dengue virus infection induces passive release of high mobility group box 1 protein by epithelial cells Systemic release of high mobility group box 1 protein during severe murine influenza HMG-1 as a Late Mediator of Endotoxin Lethality in Mice Pathogenic role of HMGB1 in SARS? |
| cord-348391-xytmq2f2 | Why do RNA viruses recombine? |
| cord-302295-nblmshni | Approaching the asymptote? |
| cord-302295-nblmshni | How important are Toll- like receptors for antimicrobial responses? |
| cord-302295-nblmshni | Sepsis studies need new direction Recombinant human activated protein C as a therapy for severe sepsis: lessons learned? |
| cord-302295-nblmshni | So, how to explore more efficiently new treatment strategies? |
| cord-302295-nblmshni | Targeting Toll- like receptors: emerging therapeutics? |
| cord-302295-nblmshni | The search for effective therapy for sepsis: back to the drawing board? |
| cord-022888-dnsdg04n | /CRTAM on gd T cells? |
| cord-022888-dnsdg04n | As the results show, could there not be a direct relationship between the HLA system and the development of SA or TBC, or in contrast, was the first patient missdiagnosed of TBC being a good prognosis SA? |
| cord-022888-dnsdg04n | Could Carabin play a role of negative regulator of B cell function? |
| cord-022888-dnsdg04n | How is the IGSF4-CRTAM axis regulated in T cells? |
| cord-022888-dnsdg04n | a one- year prospective birth cohort study PC09/16 TO WHAT EXTENT T- SPOT.TB COULD BE USED IN THE DIAGNOSIS OF TUBERCULOSIS IN CHILDREN EXPOSED TO TB INFECTION? |
| cord-006230-xta38e7j | 2´-deoxy- cAMP in human cell lines: Another second messenger? |
| cord-006230-xta38e7j | > Ser Extra- adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean? |
| cord-006230-xta38e7j | Converging of the classical mitochondria- related pathway in Parkinson and nuclear DNA- repair signaling? |
| cord-006230-xta38e7j | Detoxification by conjugation of glutathione? |
| cord-006230-xta38e7j | Is formaldehyde a good example for a"genotoxic carcinogen"with a threshold mode of action? |
| cord-006230-xta38e7j | The transcriptome analyses of human cells showed that additionally to the 30.000 protein coding sequences the human DNA codes for much more( 450.000?) |
| cord-006230-xta38e7j | possible link between diabetes and cancer? |
| cord-005497-w81ysjf9 | ( 1) Are serum- S1P levels affected by cardiac surgery? |
| cord-005497-w81ysjf9 | ( 2) Are potential alterations of serum- S1P levels related to changes of acute- phase proteins, S1P sources or carrier? |
| cord-005497-w81ysjf9 | ( 3) Is the invasiveness of the surgery a factor that may influence serum- S1P levels? |
| cord-005497-w81ysjf9 | A hybrid approach as treatment for coronary artery disease: endo- CABG or PCI first, does it matter? |
| cord-005497-w81ysjf9 | Assessing the volume of blood taken for blood culture and culture positivitydo we need to take less blood? |
| cord-005497-w81ysjf9 | Does the endotoxin adsorption of PMX column saturate in 2 hours? |
| cord-005497-w81ysjf9 | What is the useful coagulation and fibrinolysis marker for predicting extracorporeal membrane oxygenation circuit exchange due to intra- circuit thrombus? |
| cord-006229-7yoilsho | But what would happen if the HFD was switched to normal pellet diet in these diabetic rats? |
| cord-006229-7yoilsho | Core or coating material? |
| cord-006229-7yoilsho | Increased GABA release in human neocortex at high intracellular sodium and low extracellular calcium-an anti- seizure mechanism?] |
| cord-006229-7yoilsho | Occasionally there are specific questions occurring on the ruminant xenobiotic metabolism: 1) are the observed metabolites ruminant specific and formed directly in the rumen? 2) are ruminants able to cleave plant specific metabolites like glycosides to the respective aglycon? |
| cord-006229-7yoilsho | Occasionally there are specific questions occurring on the ruminant xenobiotic metabolism: 1) are the observed metabolites ruminant specific and formed directly in the rumen? 2) are ruminants able to cleave plant specific metabolites like glycosides to the respective aglycon? |
| cord-006229-7yoilsho | The data point to a role of Rac1-regulated filamentous( nuclear?) |
| cord-006229-7yoilsho | The γH2AX Assay for Genotoxic and Nongenotoxic Agents: Comparison of H2AX Phosphorylation with Cell Death Response Perturbation of mitosis through inhibition of histone acetyltransferases: the key to ochratoxin a toxicity and carcinogenicity? |
| cord-006229-7yoilsho | Vitamin D metabolism-Involved in triazole fungicide toxicity? |
| cord-006229-7yoilsho | What dictates the uptake and translocation of nanoparticles in vitro? |
| cord-006229-7yoilsho | What would happen without this exception? |
| cord-015394-uj7fe5y6 | : Do They Change during Pregnancy? |
| cord-015394-uj7fe5y6 | A Role for Intrahepatic GLUT1? |
| cord-015394-uj7fe5y6 | Androgens Influence Human Luteal Cells Function? |
| cord-015394-uj7fe5y6 | Are Contractions at 24- 32 weeks Gestation Less Painful Than Those at Full Term? |
| cord-015394-uj7fe5y6 | Could Confined Placental Mosaicism Account for Adverse Perinatal Outcomes in IVF Pregnancies? |
| cord-015394-uj7fe5y6 | Fact or Fiction? |
| cord-015394-uj7fe5y6 | Following Periconceptional Undernutrition or Twinning in Sheep? |
| cord-015394-uj7fe5y6 | In these experiments we sought to answer the question,'Does anandamide( AEA) work in the same manner as THC?' |
| cord-015394-uj7fe5y6 | Is There Evidence for Aromatase Activity in the Stroma of Postmenopausal Ovaries? |
| cord-015394-uj7fe5y6 | Is There a Role for Fatty Acids in the Pathogenesis of Pre- Eclampsia? |
| cord-015394-uj7fe5y6 | Is There a Seasonal Pattern in the Incidence of Post- Cesarean Endometritis? |
| cord-015394-uj7fe5y6 | Necessary? |
| cord-015394-uj7fe5y6 | Pregnancy Outcome? |
| cord-015394-uj7fe5y6 | Reason To Change Intrauterine Referral Practice in the Netherlands? |
| cord-015394-uj7fe5y6 | Term Preeclampsia: Any Risk for the Neonate? |
| cord-015394-uj7fe5y6 | and What Are the Roles Played by Peroxynitrite in Preeclamptic Women? |
| cord-005727-li8pwigg | ; Hospital readmission within one- year? |
| cord-005727-li8pwigg | AND/ OR CRP HELP IDENTIFY ASSOCIATED BACTERIAL INFECTION IN PATIENTS WITH INFLUENZA PNEUMONIA? |
| cord-005727-li8pwigg | After what duration of onset of AF you consider starting anticoagulation? |
| cord-005727-li8pwigg | Are you aware of any guidelines? |
| cord-005727-li8pwigg | Do you commence anti platelet therapy? |
| cord-005727-li8pwigg | Do you commence anticoagulation for acute onset AF? |
| cord-005727-li8pwigg | How long do you continue anticoagulation? |
| cord-005727-li8pwigg | If yes, which guidelines? |
| cord-005727-li8pwigg | It could be that APACHE II is over estimating the severity of illness in these individuals, or is there something about the way chronic AF is treated that affects the response to critical illness, for example, anticoagulation therapy? |
| cord-005727-li8pwigg | Next, participants were asked to explore the questions'How do you learn the mentioned items?' |
| cord-005727-li8pwigg | Should the use of video laryngoscopy be implemented as a routine for airway management in a critical care setting? |
| cord-005727-li8pwigg | So, what is lost in translation? |
| cord-005727-li8pwigg | Taurine and niacin block lung injury and fibrosis by down- regulating bleomycin- induced activation of transcription nuclear factor- kappaB in mice Antioxidants and sepsis: Can we find the ideal approach? |
| cord-005727-li8pwigg | The questions asked were; is there a protocol in your unit? |
| cord-005727-li8pwigg | What do you use for anticoagulation and in what dose? |
| cord-005727-li8pwigg | When is HIT really HIT? |
| cord-005727-li8pwigg | and'What ways of learning do you find useful or superfluous?' |
| cord-005727-li8pwigg | predict: One- year all- cause mortality in ACS? |
| cord-005727-li8pwigg | should we use? |
| cord-005814-ak5pq312 | * p<0.05 CAN vs NaCI? |
| cord-005814-ak5pq312 | 2) Are whole body changes in VAPCO2 and AVpH associated with parallel changes in regional circulation? |
| cord-005814-ak5pq312 | : We inquired all the nurses of the Intensive Care Unit of an Regional Hospital by an semiestructurated questionary which included personal data: age, sex, contractual relation, professional experience.., and opinion data: do you think to inform relatives is a nurse task?. |
| cord-005814-ak5pq312 | A HEROE? |
| cord-005814-ak5pq312 | A PROGNOSTIC FACTOR? |
| cord-005814-ak5pq312 | After more than 2 years clinical experience two aspects were investigated: What effort is necessary to install and support a CIS, and what is the benefit for patients and personnel on the ICU? |
| cord-005814-ak5pq312 | Are circular circuits safe? |
| cord-005814-ak5pq312 | CO, MAP, CVP, PCWP, PaO?, and Pv~ remained unchan NO administration. |
| cord-005814-ak5pq312 | Case report: A 41 year old man developed typical skin manifestations of HSP following an episode of severe( biliary?) |
| cord-005814-ak5pq312 | GS score difference seems suggestive and can be that an abnormal cerebral activity( hipofisary hormones?) may play a crucial role on onset of ARF in these patients. |
| cord-005814-ak5pq312 | In 35 patients with cardiogenic shock due to ischemic heart disease( N=26), heart failure( N=7) and valvulopathy( N=2), hemod31aamic data including measures of intravascular pressures, cardiac output and mixed venous gases were collected at regular times intervals, at least 3 times a da?. |
| cord-005814-ak5pq312 | In all 13 patients with positive blood cultures the clinical course of S, infection was complicated:? |
| cord-005814-ak5pq312 | In case ot GER persistence at the pH- metry on? |
| cord-005814-ak5pq312 | In this stud?', wc recorded the gastrointestinal motility of critically ill patients with abundant(> 250 mL/24 hours) fasting gastric aspirates. |
| cord-005814-ak5pq312 | Is there any way to individualise the triple H therapy when it is necessary? |
| cord-005814-ak5pq312 | TA Buckle? |
| cord-005814-ak5pq312 | The absence of this mechanism( right heart impairement?) |
| cord-005814-ak5pq312 | Therefore, extreme attention should be paid to the maintenance of an adequate mean arterial blood pressure( above 90 mmHg?) |
| cord-005814-ak5pq312 | We were considered that a patient had Ventilator associated pneumonia( VAP) when the specimens of Bronchoalveolar Lavage( BAL) or Protected Specimen Brush( PSI?,), ebb'ned through the bronchoscope, had one or more microorganisms in concentrations greater than 105 and 103 cfu/ ml respectively. |
| cord-005814-ak5pq312 | Where are we?. |
| cord-005814-ak5pq312 | Which of the next informafions do you think is more important? |
| cord-005814-ak5pq312 | and AVpH also reflect the onset of tissue hypoxia during endotoxemia? |
| cord-005814-ak5pq312 | thrombolytic therapy or pulmonary embolectomy? |
| cord-004282-tox3tuzz | , causing an innate immune response, although this cell line is more resistant to Cd2? |
| cord-004282-tox3tuzz | 3 Cd2? |
| cord-004282-tox3tuzz | After LPS or Cd2? |
| cord-004282-tox3tuzz | Also, a previous study showed that Cd2? |
| cord-004282-tox3tuzz | Cd2? |
| cord-004282-tox3tuzz | Cd2? |
| cord-004282-tox3tuzz | Cd2? |
| cord-004282-tox3tuzz | Cells were treated with 20 lM Cadmium( 4 lg/10 6 cells); then, intracellular concentration of Cd2? |
| cord-004282-tox3tuzz | Concerning the Cd2? |
| cord-004282-tox3tuzz | Data sets were submitted to a Kolmogorov- Smirnov test to check normality of distributions; significant differences within normal distributions were checked by one- way ANOVA followed by a Dunnett's test for gene expression, cytokine release and Cd2? |
| cord-004282-tox3tuzz | Each Cd2? |
| cord-004282-tox3tuzz | Furthermore, Cd2? |
| cord-004282-tox3tuzz | In our study, the exposure of MDCK to Cd2? |
| cord-004282-tox3tuzz | In our study, we treated MDCK with 20 lM Cd2?, which was equivalent to 1.9% of the 4-h DL100( 105 mg/ kg) value after oral administration in dogs( Venugopal and Luckey 1975). |
| cord-004282-tox3tuzz | In particular, Cd2? |
| cord-004282-tox3tuzz | In particular, Cd2? |
| cord-004282-tox3tuzz | In particular, we observed 0.08%, 0.11% and 1.1% Cd2? |
| cord-004282-tox3tuzz | In particular, we observed at different times of incubation with 20 lM Cd2? |
| cord-004282-tox3tuzz | In this study, we chose cadmium( Cd2?) as a noninfectious stressor. |
| cord-004282-tox3tuzz | Indeed, exposure to Cd2? |
| cord-004282-tox3tuzz | MDCK cells showed the ability to absorb low levels of Cd2? |
| cord-004282-tox3tuzz | Many studies demonstrated the ability of Cd2? |
| cord-004282-tox3tuzz | Moreover, low levels of Cd2? |
| cord-004282-tox3tuzz | Our data showed a significant increase of intracellular Cd2? |
| cord-004282-tox3tuzz | Regarding IL-6 release, we observed a significant increase of this cytokine in cell supernatants after 3 h( 54 ± 3.3 pg/ ml) and 24 h( 51 ± 6.8 pg/ ml) of Cd2? |
| cord-004282-tox3tuzz | The effects of CD14 and IL-27 on induction of endotoxin tolerance in human monocytes and macrophages Defective LPS signaling in C3H/ HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene Innate immunity to intracellular LPS Reverse transcription real- time PCR for detection of porcine interferon a and b genes IPEC- J2 cells as reporter system of the anti- inflammatory control actions of interferon- alpha A pig tonsil cell colture model for evaluating oral, low- dose INF- a treatments Effects of cadmium chloride on the functional state of human intestinal cells Cytokine expression in an ex vivo culture system of duodenal samples from dogs with chronic enteropathies: modulation by probiotic bacteria Residual endotoxin contaminations in recombinant proteins are sufficient to activate human CD1c? |
| cord-004282-tox3tuzz | The major mechanism behind Cd2? |
| cord-004282-tox3tuzz | These data outline the negative repercussions of lab contamination by LPS or Cd2? |
| cord-004282-tox3tuzz | We tested the ability of MDCK to adsorb Cd2? |
| cord-004282-tox3tuzz | absorption after 1, 3 and 24 h of exposure, respectively, using 20 lM Cd2? |
| cord-004282-tox3tuzz | at different times after exposure: 1, 3 and 24 h. Cells were treated with 20 lM Cadmium( 4 lg/10 6 cells); then, intracellular concentration of Cd2? |
| cord-004282-tox3tuzz | concentration was checked in quintuplicate and intracellular Cd2? |
| cord-004282-tox3tuzz | exposure caused an inflammatory response characterized by upregulation of genes expression and IL-6 release; this was associated to Cd2? |
| cord-004282-tox3tuzz | lM Cd2? |
| cord-004282-tox3tuzz | toxicity has now been shown in nearly every organ and tissue of the body and the kidney is a critical organ for Cd2? |
| cord-015021-pol2qm74 | ( 3) Should future clinical trials be based on new classifications of illness such as MODS, SIRS, APACHE III, SAP II, MRM, etc., or should trials be dedicated to specific diseases-urinary tract infections, pneumonia, trauma patients, cardiac surgery and other specific problems, rather than generalized problems of sepsis, the sepsis syndrome and other classifications? |
| cord-015021-pol2qm74 | 3-Is the ACCP classification of sepsis useful at the bedside to select oatients? |
| cord-015021-pol2qm74 | Abnormally high skeletal muscle pO 2 in septic patients and its normalization during recovery: Evidence against tissue hypoxia but for impaired oxygen metabolism of skeletal muscle? |
| cord-015021-pol2qm74 | Administration of exogenous IFN? |
| cord-015021-pol2qm74 | And, finally, how can the participants be sure that the trial will be stopped at the right time, to ensure that no treatment is given to any patient that might be harmful? |
| cord-015021-pol2qm74 | Are all eligible patients being studied, and their results reported? |
| cord-015021-pol2qm74 | Are all the participants truly unbiased about the relative merits of the regimens being studied? |
| cord-015021-pol2qm74 | Before using the model for risk of death in septic patients, is it mandatory to validate it( by calibration, i.e. goodness of fit, and discrin'dnation, i.e., ROC curves) first on a data base using the same definition for sepsis as in the trial and secondly on the placebo group of the trial? |
| cord-015021-pol2qm74 | Can it achives a significant improvement in the septic course, organ dysfunction, and final outcome? |
| cord-015021-pol2qm74 | Conversely, administration of anti- IFN? |
| cord-015021-pol2qm74 | Correlatively the RNI inhibitor MMLA induces in vitro a decrease in the rate of bacterial killing, fxom 78% to 57%, in macrophages triggered with IFN-?+ LPS. |
| cord-015021-pol2qm74 | How can organ dysfunction and/or failure be defined? |
| cord-015021-pol2qm74 | How should we decide which of them should be brought to clinical trial? |
| cord-015021-pol2qm74 | If there is agreement that thin is an appropriate antibiotic protocol, should it not be used in all seriously ill septic patients in the hospital? |
| cord-015021-pol2qm74 | In contrast, GF109203X significantly reduced ICAM-1 expression induced by Interferon- y( IFN-?) |
| cord-015021-pol2qm74 | In fact, the IFN-? and IL-1 induced adhesion of PBMC to cytokine treated HUVEC could be downregulated by the PKC- inhibitor, whereas TNFc~-and LPS- mediated adhesion was not influenced. |
| cord-015021-pol2qm74 | In other words, should we now begin to have clinical trials on specific diseases with causes that are known and can be attacked? |
| cord-015021-pol2qm74 | Interferon-? |
| cord-015021-pol2qm74 | Is like being compared with like-are all the end points and the standards for measuring them clearly defined so that they can not be misunderstood? |
| cord-015021-pol2qm74 | Is there any role for antioxidative therapy in sepsis? |
| cord-015021-pol2qm74 | Is truly informed consent being sought that will satisfy not only the patient's right to choose what happens to him, but also the law of the land? |
| cord-015021-pol2qm74 | MIF secretion also was induced by TNFoc( 1 ng/ ml) and IFN? |
| cord-015021-pol2qm74 | MIF secretion is induced by LPS, TNFc~ and IFN?. |
| cord-015021-pol2qm74 | Macrophages of C57BL/10ScCr mice are incapable of producing interferon-~( IFN~) which we could show to be obligatory for the production of IFN? |
| cord-015021-pol2qm74 | On closer investigation the impaired IFN? |
| cord-015021-pol2qm74 | The IFN? |
| cord-015021-pol2qm74 | The absence of sensitization to LPS in Lps d C57BL/10ScCr mice was identified as being due to their inability to produce interferon-7( IFN?). |
| cord-015021-pol2qm74 | The clinical"take"rate o? cultured epithelial autografts( CEA) has been observed to Increase with transplantation to allodermls, but the reasons for the improved clinical performance have not yet been defined. |
| cord-015021-pol2qm74 | The inability to produce adequate amounts of IL-2, most likely attributable to alterations in the transmission of signals from the cell membrane to the nucleus, results in incomplete proliferative T- cell responses to antigenic stimuli, while a lack of? |
| cord-015021-pol2qm74 | There are reports of nentrophil dysfunction in inflammatory disorders of the skin( 2), Are there dysfunctions concerning the unspecific host defense in SIRS, as well? |
| cord-015021-pol2qm74 | This has not happened, however, and the question is"Why not"? |
| cord-015021-pol2qm74 | This might be due to a preexisting( genetic?) or more likely to an epiphenomenal receptor defect. |
| cord-015021-pol2qm74 | We have investigated the proinflaznmatory oytokine secretion patter~ by PMN in patients following major~hermal or tra~ matic injury and in volunteers fellowinq endotoxemia.? |
| cord-015021-pol2qm74 | What are the definitions? |
| cord-015021-pol2qm74 | What are the issues, then, in 1994, to be dealt with at this symposium and congress? |
| cord-015021-pol2qm74 | What are the mechanisms? |
| cord-015021-pol2qm74 | What is the aplpiieability of study results in typical clinical situations? |
| cord-015021-pol2qm74 | What is the availability of speciftc antibiotics at a participating hospital? |
| cord-015021-pol2qm74 | Will the patient's physicians agree to the protocol choice? |
| cord-015021-pol2qm74 | Will they be helpful in the study and esro of patients? |
| cord-015021-pol2qm74 | Will this contribute to better clinical trials, information basis and better research? |
| cord-015021-pol2qm74 | Will we benefit Oleo from a more precise classification and definition of a non- outjty, a hodgu- podge of human disorders which have charsmeristic.s and manifestations of tissue injury, inflammation and infactian? |
| cord-015021-pol2qm74 | and?-IFN and T- helper-2( Th2) acting principally in inducing antibody formation with a secretion of IL-4, IL-5, IL-10 and TNF-[3 has still to be established within the context of major trauma. |
| cord-015021-pol2qm74 | anti- IFN-?( p<0.05). |
| cord-015021-pol2qm74 | or is it better to use a specific model for each trial? |
| cord-015021-pol2qm74 | ~is s?. |
| cord-014996-p6q0f37c | ( G? M), succinate( S) or ascorbate/ TMPD( A/ T) were used as substrates to test the function of complex I, II and IV, respectively. |
| cord-014996-p6q0f37c | ( Na? |
| cord-014996-p6q0f37c | ** Mean ± SD mean ± standard deviation, min minimum, Max, maximum, PBW 50( men) or 45.5( female)? |
| cord-014996-p6q0f37c | ** p\ 0.01 Tables 1??? |
| cord-014996-p6q0f37c | ** p\ 0.01 Tables 1??? |
| cord-014996-p6q0f37c | ** p\ 0.01 Tables 1??? |
| cord-014996-p6q0f37c | -3.61 to? |
| cord-014996-p6q0f37c | /K? |
| cord-014996-p6q0f37c | /K? |
| cord-014996-p6q0f37c | /K? |
| cord-014996-p6q0f37c | /K? |
| cord-014996-p6q0f37c | /K?-ATPase). |
| cord-014996-p6q0f37c | 17 pts received 3- 5 ml/ kg( 250 ml) HHES( 7.2% NaCl? |
| cord-014996-p6q0f37c | 2.02 L, mean arithmetic error ± SD:? |
| cord-014996-p6q0f37c | A brief history of procalcitonin Biomarkers of sepsis: is procalcitonin ready for prime time? |
| cord-014996-p6q0f37c | A protective role of heterozygousity for the functionally relevant TNFRSF1B? |
| cord-014996-p6q0f37c | A similar pattern was seen in the hepatic? |
| cord-014996-p6q0f37c | After 4 h of ventilation, animals were sacrificed and cardiac function was measured ex vivo in a Langendorff setup and expressed as developed pressure and? |
| cord-014996-p6q0f37c | All files were reviewed to assess the diagnosis of early- onset pneumonia P(?), or not P(-) during the first 5 days of ICU stay. |
| cord-014996-p6q0f37c | CD11c? |
| cord-014996-p6q0f37c | Can they be used as a diagnostic tool in conjunction with procalcitonin in order to direct antimicrobial therapy? |
| cord-014996-p6q0f37c | Characteristics of P(?) |
| cord-014996-p6q0f37c | Data of resistance( R rs), elastance( E rs) and total positive end expiratory pressure( PEEP tot) were obtained by fitting the equation Paw= R rs 9 V 0? |
| cord-014996-p6q0f37c | Developed pressure( p\ 0.01) and? |
| cord-014996-p6q0f37c | Four trials of one hour each were performed at a constant FiO 2 60% during( 1) spontaneous breathing( SB) via a Venturi mask,( 2) CPAP 1,( 3) CPAP? |
| cord-014996-p6q0f37c | Glutamate? |
| cord-014996-p6q0f37c | I am the Best Clinical Educator … are you!? |
| cord-014996-p6q0f37c | In the presence of sevoflurane mRNA level of the a 1-subunit mRNA of Na? |
| cord-014996-p6q0f37c | Levels of TNFa were significantly reduced in the LPS? |
| cord-014996-p6q0f37c | Our aim was to investigate the influence of 1 MAC(= 2.2 vol%) sevoflurane on mRNA and protein levels of ENaC and Na? |
| cord-014996-p6q0f37c | Out the total population, 51.6% of patients, with a median( IQR) pre- operative CRS of 7( 5- 8) underwent a coronary- artery bypass grafting( CABG) surgery, whereas 20.7% of them, with a preoperative median( IQR) NYHA of 3( 2.25- 3) needed a valve replacement( VR) and 16.1% of them combined( CABG? VR) operations; moreover, 11.6% of patients underwent other type of cardiac and aortic surgery. |
| cord-014996-p6q0f37c | P(?) was defined by the presence of a new pulmonary infiltrate on chest radiography, persistent for at least 48 h, associated with either positive quantitative culture of the endotracheal aspirates, either, in case of lack of bacteriological sample, conjunction of purulent sputum and hypoxemia( P/ F\ 200). |
| cord-014996-p6q0f37c | Patients were deemed as having hypoactive delirium if they were DSM positive by the reference rater and had RASS-3 to 0, or having hyperactive delirium if their RASS was between? 1 and? 4. |
| cord-014996-p6q0f37c | Patients were deemed as having hypoactive delirium if they were DSM positive by the reference rater and had RASS-3 to 0, or having hyperactive delirium if their RASS was between? 1 and? 4. |
| cord-014996-p6q0f37c | Previous studies have shown that halothane decreases Na? |
| cord-014996-p6q0f37c | Secondary indices derived from the ICP waveform were analyzed by ICM? software. |
| cord-014996-p6q0f37c | Septic shock( SS) has been defined as sepsis related hypotension despite adequate fluid resuscitation? |
| cord-014996-p6q0f37c | Sequential Kaplan- Meier survival analysis of TNFRSF1B? |
| cord-014996-p6q0f37c | Sequential Kaplan- Meier survival analysis of TNFRSF1B? |
| cord-014996-p6q0f37c | T lymphocytes were distinguished from the other lymphocyte subpopulation as cells labeled with anti- CD3 monoclonal antibody but negative for CD56 staining( CD3? |
| cord-014996-p6q0f37c | The fluid- induced changes in invasive(? 20 ± 36%) and non invasive(? |
| cord-014996-p6q0f37c | The fluid- induced changes in invasive(? 20 ± 36%) and non invasive(? |
| cord-014996-p6q0f37c | V T/ C rs? |
| cord-014996-p6q0f37c | What alters physicians'decisions to admit to the coronary care unit? |
| cord-014996-p6q0f37c | a- subunit Na? |
| cord-014996-p6q0f37c | and 2??? |
| cord-014996-p6q0f37c | and 2??? |
| cord-014996-p6q0f37c | and 2??? |
| cord-014996-p6q0f37c | and CD11c- CD123? |
| cord-014996-p6q0f37c | and-1.26 ± 5.41 kg) and slightly better between BWC and AdjTFB( 0.714 and? 0.18 ± 3.68Kg). |
| cord-014996-p6q0f37c | and-308, LTA? |
| cord-014996-p6q0f37c | and-308, LTA? |