bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
lung injury	785
mg kg	751
intensive care	734
septic shock	661
gene expression	632
endothelial cells	611
inflammatory response	581
ng ml	560
immune response	503
present study	492
control group	463
acute lung	432
nitric oxide	414
mechanical ventilation	374
pg ml	373
critically ill	360
care unit	358
mrna expression	357
epithelial cells	351
inflammatory cytokines	351
oxidative stress	324
innate immune	321
significantly higher	318
blood pressure	317
like receptor	311
immune responses	302
cell line	302
significantly increased	301
cell lines	293
critical care	290
immune system	289
protein expression	285
bone marrow	284
ill patients	284
acute respiratory	281
flow cytometry	280
important role	280
significantly reduced	279
peripheral blood	277
blood flow	276
severe sepsis	275
organ failure	273
two groups	271
necrosis factor	270
results suggest	263
apache ii	263
cell death	259
western blot	258
smooth muscle	254
dendritic cells	254
respiratory distress	250
mean age	244
cytokine production	243
patients admitted	235
significant differences	226
statistically significant	225
distress syndrome	223
inflammatory responses	223
dependent manner	223
tumor necrosis	222
cell surface	221
cell proliferation	221
nervous system	219
growth factor	216
mouse model	215
significant difference	213
data suggest	213
cell types	207
endothelial cell	206
transcription factor	206
lung tissue	203
blood samples	199
body weight	195
significant increase	195
mg ml	193
performed using	190
deficient mice	188
statistical analysis	187
septic patients	187
cardiac output	185
cd cd	185
ml kg	184
mrna levels	182
spinal cord	181
risk factors	180
lps stimulation	179
results indicate	177
significantly lower	177
ko mice	176
lps group	175
respiratory failure	175
mortality rate	174
wild type	173
signaling pathways	172
plasma levels	172
animal models	171
multiple organ	171
immune cells	169
cell activation	169
signal transduction	169
transgenic mice	168
taken together	166
protein kinase	165
icu patients	165
central nervous	161
expression levels	161
proinflammatory cytokines	160
organ dysfunction	160
icu admission	155
previous studies	154
reactive oxygen	154
adhesion molecules	154
lps challenge	154
time points	154
severe hepatitis	153
results show	153
time pcr	153
binding protein	153
may contribute	153
heart failure	153
arterial pressure	151
inflammatory cytokine	151
renal failure	150
arterial blood	150
hospital mortality	148
inflammatory mediators	148
amino acid	148
western blotting	148
innate immunity	147
lps injection	146
high levels	145
cardiac surgery	143
lung inflammation	143
induced lung	143
surfactant protein	141
heart rate	141
cardiac arrest	140
blot analysis	140
positive cells	140
icu stay	140
type i	140
wt mice	140
stem cells	139
mononuclear cells	139
significantly decreased	138
tumor cells	138
gestational age	137
like receptors	135
protein levels	134
brain injury	133
molecular mechanisms	133
class i	133
ml min	132
data indicate	131
mast cells	131
pulmonary artery	131
logistic regression	130
oxygen species	130
escherichia coli	130
ex vivo	130
side effects	130
activated protein	129
signaling pathway	129
muscle cells	127
serum levels	127
determine whether	127
acute phase	126
findings suggest	126
vascular permeability	125
care units	124
transcription factors	124
measured using	124
previously described	124
cell responses	123
ii score	122
lps administration	122
cell cycle	121
results showed	120
alveolar macrophages	119
tlr signaling	118
first time	118
mechanically ventilated	118
microglial cells	118
clinical trials	118
control mice	117
lung tissues	116
patients undergoing	115
negative bacteria	115
inhibitory effect	115
dna damage	115
may play	114
university hospital	114
pulmonary vascular	113
whole blood	113
room temperature	113
induced acute	113
pregnant women	112
mhc class	112
vascular endothelial	111
glial cells	111
survival rate	109
tissue damage	109
type mice	108
cell culture	108
may also	106
increased expression	106
oxide synthase	106
knockout mice	105
inflammatory cells	105
cord uid	105
systemic inflammatory	105
multiple sclerosis	105
doc id	105
observational study	104
adhesion molecule	104
liver disease	104
significantly different	104
critical role	103
mean arterial	103
protective effect	103
nkt cells	102
animal model	101
cd cells	101
inflammatory diseases	101
liver failure	101
induced ali	100
extracellular matrix	99
trauma patients	99
adaptive immune	99
patients received	98
plasma membrane	98
time point	98
determined using	98
tlr expression	98
differentially expressed	97
host defense	97
bronchoalveolar lavage	97
patients without	97
medical center	96
results demonstrate	96
culture medium	96
significant reduction	96
heme oxygenase	96
influenza virus	95
tidal volume	95
poly i	95
total rna	95
healthy volunteers	95
hepatic encephalopathy	94
pulmonary disease	94
previously reported	94
central venous	94
monoclonal antibodies	93
amino acids	93
chronic obstructive	92
blood vessels	92
stem cell	92
rheumatoid arthritis	92
data show	91
study period	91
bl mice	91
cell type	91
risk factor	91
rat model	91
cohort study	91
fold increase	91
monoclonal antibody	90
lymph nodes	90
group i	90
pulmonary edema	89
day mortality	89
real time	89
also found	89
type ii	89
prospective study	89
may lead	88
vascular resistance	88
mass spectrometry	88
trained immunity	88
molecular weight	87
key role	87
significant decrease	87
type diabetes	87
mg dl	86
systemic inflammation	86
ang ii	86
long term	86
treated mice	86
recent studies	85
cell adhesion	85
myocardial infarction	85
nuclear factor	84
pulmonary surfactant	84
regression analysis	84
statistical significance	83
blood gas	83
analysis revealed	83
within hours	83
obstructive pulmonary	82
adult patients	82
inflammatory effects	82
increased levels	82
th cells	82
cancer cells	82
increased risk	82
ventilated patients	81
blood cells	81
treated animals	81
adaptive immunity	81
signalling pathway	81
cell migration	81
oxygen saturation	81
replacement therapy	80
activating factor	80
previously shown	80
wistar rats	80
receptor antagonist	80
first trimester	80
white matter	80
class ii	80
venous blood	80
blood mononuclear	79
cardiac index	79
three groups	79
tissue injury	79
endothelial barrier	79
influenza infection	79
sofa score	79
cytokine levels	78
peritoneal macrophages	78
gas exchange	78
higher levels	78
cell viability	78
fatty acid	78
apoptotic cells	78
brain barrier	78
kg min	78
years old	78
emergency department	78
high risk	78
also observed	77
pulmonary hypertension	77
nk cells	77
specific cd	77
breast cancer	77
patients treated	76
nlrp inflammasome	76
retrospective study	76
renal function	76
barrier function	76
way anova	76
protective effects	76
control animals	75
protein level	75
epithelial cell	75
reperfusion injury	75
hospital stay	75
bacterial infection	75
bacterial infections	75
pulmonary fibrosis	75
reactive protein	74
significant changes	74
infectious diseases	74
analyzed using	74
oxygen delivery	74
cell cultures	74
blood glucose	74
lps treatment	74
viral infection	74
mortality rates	74
growth factors	74
united kingdom	73
respiratory tract	73
critical illness	72
two different	72
clinical trial	72
fetal growth	72
previous study	72
consecutive patients	72
left ventricular	72
data demonstrate	72
liver transplantation	72
virus infection	71
blood gases	71
lung disease	71
mm hg	71
chronic inflammatory	71
analysis showed	70
adverse effects	70
days post	70
hemorrhagic shock	70
least one	70
one patient	70
mast cell	70
cytokine release	69
crucial role	69
ali ards	69
hek cells	69
schwann cells	69
pao fio	69
red blood	68
mice showed	68
pivotal role	68
progenitor cells	68
fatty acids	68
assessed using	68
cell membrane	67
healthy controls	67
microglial activation	67
blood loss	67
time course	67
lavage fluid	67
mouse models	67
renal replacement	67
first hours	67
patients died	67
sirna nanoparticles	66
vitro studies	66
icu mortality	66
hydrogen peroxide	66
potential therapeutic	66
kidney injury	66
may provide	66
specific antibodies	66
mechanisms underlying	65
investigate whether	65
acute renal	65
cells expressing	65
vascular smooth	65
widely used	65
saps ii	65
single cell	65
study design	64
inflammatory processes	64
pulmonary inflammation	64
surface expression	64
antigen presentation	64
beneficial effects	64
ob gyn	64
binding site	64
airway pressure	64
skeletal muscle	64
angiotensin ii	63
high mortality	63
dorsal funiculus	63
may represent	63
nod mice	63
major role	63
central role	63
one hour	62
electron microscopy	62
cardiac function	62
sqad vite	62
small intestine	62
current study	62
proinflammatory cytokine	62
microvascular endothelial	62
significantly associated	62
ischemia reperfusion	62
respiratory syndrome	62
tumor cell	62
murine model	62
respiratory rate	62
ttp ko	61
commercially available	61
ms ms	61
coupled receptors	61
coronary artery	61
bovine serum	61
pressure support	61
mesothelial cells	61
high affinity	61
treated cells	61
well plates	61
neutrophil recruitment	61
informed consent	61
tnf production	61
adverse events	61
high dose	61
poorly understood	60
inducible nitric	60
three times	60
pseudomonas aeruginosa	60
predictive value	60
copd patients	60
anp high	60
lung cancer	60
lps induced	60
myeloid cells	60
presenting cells	60
mice compared	59
mice treated	59
protein synthesis	59
investigated whether	59
challenged ttp	59
preliminary results	59
amniotic fluid	59
autoimmune diseases	59
inflammatory bowel	59
considered significant	58
median age	58
acute kidney	58
cells showed	58
united states	58
study showed	58
plasma concentrations	58
significantly elevated	58
increased significantly	58
signalling pathways	57
ics ii	57
birth weight	57
inhibitory effects	57
nuclear translocation	57
following lps	57
control groups	57
human monocytes	57
primary human	57
group ii	57
low dose	57
intestinal epithelial	57
recent years	57
immune cell	57
severe acute	57
viral infections	57
expression level	57
cell response	57
commonly used	56
significantly inhibited	56
chronic liver	56
well known	56
three different	56
receptor expression	56
low levels	56
clinical studies	56
cell receptor	56
study group	56
mice lacking	56
tlr ligands	56
family members	56
highly expressed	56
inkt cells	56
inflammatory effect	56
receptor activation	56
membrane potential	56
gram negative	56
ca i	56
two patients	55
ginsenoside rb	55
inflammatory conditions	55
mechanisms involved	55
treated rats	55
significant correlation	55
staphylococcus aureus	55
showed significant	55
tissue factor	55
liver injury	55
recognition receptors	55
total number	55
year period	54
clinical signs	54
total protein	54
mean values	54
outer membrane	54
fold higher	54
liver cirrhosis	54
antigen presenting	54
brain tissue	54
tyrosine kinase	54
adipose tissue	54
positive control	54
mesenchymal stem	53
cytokine secretion	53
prospective observational	53
acute pancreatitis	53
lactate levels	53
therapeutic potential	53
neurodegenerative diseases	53
healthy subjects	53
blood cell	53
dose dependent	53
endothelial growth	53
ovarian cancer	53
cell growth	53
high concentrations	53
trophoblast cells	53
preterm birth	53
confocal microscopy	53
may result	53
viral replication	52
gel electrophoresis	52
also significantly	52
infl ammatory	52
promoter activity	52
acute inflammation	52
cell population	52
per group	52
month period	52
new therapeutic	52
recombinant human	52
cell differentiation	52
several studies	52
university medical	52
quantitative real	52
santa cruz	51
human lung	51
serum albumin	51
cancer cell	51
liver function	51
bowel disease	51
induced activation	51
tg mice	51
cd expression	51
natural killer	51
also known	51
expression pattern	51
endothelial permeability	51
early stage	51
gastrointestinal tract	51
inclusion criteria	51
cell signaling	50
regulatory factor	50
cell wall	50
antibiotic therapy	50
increased mortality	50
surgical patients	50
vg vd	50
preterm delivery	50
significantly greater	50
traumatic brain	50
mpo activity	50
transforming growth	50
binding sites	50
high pmn	50
remains unclear	49
necrotizing enterocolitis	49
head injury	49
elderly patients	49
mrna level	49
cecal ligation	49
short term	49
differential expression	49
lipid peroxidation	49
future studies	49
induced inflammation	49
different time	49
dendritic cell	49
pharmakologie und	49
negative control	49
tumour necrosis	49
demographic data	49
menstrual cycle	49
health care	49
data obtained	49
even though	49
vite nps	49
animal studies	49
hospital discharge	49
response syndrome	49
linked immunosorbent	49
cardiogenic shock	49
genes involved	49
target genes	49
neutrophil infiltration	49
glucose levels	49
treatment group	48
oxygen consumption	48
tumor growth	48
coupled receptor	48
kg body	48
disease severity	48
diabetes mellitus	48
group compared	48
complement activation	48
lung function	48
standard deviation	48
inflammatory cell	48
studies showed	48
acute inflammatory	48
postoperative period	48
analysis using	48
surfactant proteins	48
endoplasmic reticulum	48
vitro model	48
protective role	48
biological activity	48
animal experiments	48
metabolic acidosis	48
multivariate analysis	48
may help	47
infected cells	47
und toxikologie	47
cell count	47
preterm labor	47
infected mice	47
inflammatory properties	47
wide range	47
dawley rats	47
induced apoptosis	47
growth restriction	47
included patients	47
compared using	47
pilot study	47
patients suffering	47
among patients	47
host response	47
kg day	47
higher mortality	46
blood cultures	46
wound healing	46
san diego	46
three days	46
chronic inflammation	46
first days	46
novel therapeutic	46
human myometrium	46
stimulating factor	46
acute liver	46
uric acid	46
immunosorbent assay	46
bacterial translocation	46
inflammatory stimuli	46
free radicals	46
clinical manifestations	46
pattern recognition	46
weight loss	46
elevated levels	46
patients receiving	46
medical university	45
therapeutic strategy	45
therapeutic strategies	45
free radical	45
cytokine expression	45
blood transfusion	45
clinically relevant	45
chemokine receptor	45
induced inflammatory	45
different types	45
airway inflammation	45
risk assessment	45
fat diet	45
kupffer cells	45
different cell	45
macrophage activation	45
receptor signaling	45
cell survival	45
ethics committee	45
inflammatory reaction	45
may explain	45
age years	45
expressed genes	45
associated molecular	44
monocytes macrophages	44
host cells	44
macrophage cell	44
potential role	44
kg bw	44
significantly improved	44
chain reaction	44
carbon monoxide	44
reactive astrocytes	44
tlr activation	44
pathological changes	44
th day	44
provide evidence	44
umbilical cord	44
heat shock	44
pulmonary embolism	44
cell function	44
umbilical vein	44
i molecules	44
positive correlation	44
therapeutic target	44
similar results	44
nadph oxidase	44
described previously	44
ms patients	44
systemic vascular	44
defi cient	44
heart disease	44
neuropathic pain	43
cardiac hypertrophy	43
mobility group	43
converting enzyme	43
blood volume	43
intraperitoneal injection	43
studies will	43
study demonstrates	43
inflammatory markers	43
urinary tract	43
pregnant rats	43
ros production	43
cells express	43
ards patients	43
flow cytometric	43
cells treated	43
dry weight	43
better understanding	43
vascular tone	43
ng cells	43
therapeutic hypothermia	43
immune activation	43
clinical course	43
body temperature	43
hepatorenal syndrome	43
endotoxic shock	43
intravenous injection	43
beneficial effect	43
closely related	42
weeks gestation	42
derived macrophages	42
intercellular adhesion	42
right ventricular	42
pelvic pain	42
also increased	42
mixed venous	42
clinical practice	42
cell subsets	42
levels increased	42
dna repair	42
cell populations	42
fetal membranes	42
first day	42
ejection fraction	42
organ injury	42
platelet count	42
platelet aggregation	42
ml lps	42
white blood	42
cardiovascular disease	42
portal vein	42
alveolar epithelial	42
map kinase	42
days later	42
blood coagulation	41
therapeutic effect	41
group box	41
large number	41
toxic effects	41
within days	41
cigarette smoke	41
poor outcome	41
activated microglia	41
care medicine	41
weight gain	41
clinical data	41
ad libitum	41
spontaneous breathing	41
fetal brain	41
ug ml	41
human umbilical	41
inflammatory process	41
igg liposomes	41
well tolerated	41
surface area	41
human endothelial	41
quantitative rt	41
sirna nanoparticle	41
male wistar	41
leukocyte recruitment	41
icu discharge	41
urine output	41
factor alpha	41
cancer patients	41
protein concentration	41
immunohistochemical analysis	41
sepsis syndrome	41
injured lungs	41
transcriptional regulation	40
buffered saline	40
induced il	40
bacterial lipopolysaccharide	40
effector cells	40
transgenic mouse	40
th cytokines	40
cell counts	40
analysed using	40
respiratory system	40
preliminary data	40
hemodynamic parameters	40
cesarean section	40
decreased significantly	40
systemic circulation	40
disease progression	40
results obtained	40
pulmonary microvascular	40
pulmonary function	40
cell apoptosis	40
scoring system	40
stromal cells	40
facs analysis	40
studies suggest	40
early phase	40
lps exposure	40
study shows	40
tissue samples	40
expression profiles	40
exact test	40
strand breaks	40
findings indicate	40
cell infiltration	40
cytokine il	40
ion channels	40
disseminated intravascular	40
plasma cells	39
lung epithelial	39
cells using	39
mycobacterium tuberculosis	39
studies using	39
cell development	39
abdominal surgery	39
inos expression	39
time rt	39
molecular patterns	39
target cells	39
bile acid	39
cells may	39
venous pressure	39
surgical icu	39
cystic fibrosis	39
binding proteins	39
plasminogen activator	39
portal hypertension	39
essential role	39
authors declare	39
therapeutic intervention	39
study aimed	39
peritoneal cavity	39
primary outcome	39
platelet activation	39
physiological conditions	39
polymerase chain	39
culture media	39
invasive ventilation	39
control cells	38
brain regions	38
culture system	38
cerebral cortex	38
host immune	38
retrospective cohort	38
pleural effusion	38
pl flux	38
experimental model	38
human peripheral	38
lung diseases	38
high fat	38
usp expression	38
evidence suggests	38
underlying mechanisms	38
crp levels	38
induced expression	38
fluorescence microscopy	38
drinking water	38
exclusion criteria	38
infl ammation	38
quantitative pcr	38
clinical outcomes	38
fl uid	38
bd biosciences	38
immune complexes	38
surface markers	38
cord blood	38
pulmonary arterial	38
streptococcus pneumoniae	38
morphological changes	38
clinical outcome	38
data analysis	38
reporter gene	38
normal human	37
ultrasound stimulation	37
previous reports	37
last years	37
vitro experiments	37
two weeks	37
cell number	37
cytokine response	37
fluid resuscitation	37
linear regression	37
independent experiments	37
candida albicans	37
gene transcription	37
significant change	37
significantly less	37
enzyme activity	37
retrospective analysis	37
also showed	37
female mice	37
induced cytokine	37
blood culture	37
therapeutic targets	37
vivo studies	37
systemic lupus	37
five patients	37
secondary antibody	37
thermo fisher	37
roc curve	37
tlr agonists	37
early diagnosis	37
endothelial dysfunction	37
intravascular coagulation	37
transduction pathways	37
renal dysfunction	36
interferon regulatory	36
cytokine profile	36
shock patients	36
high doses	36
protease inhibitor	36
six patients	36
severe ards	36
takes place	36
oxidative damage	36
women undergoing	36
important roles	36
mice received	36
human skin	36
studied patients	36
cervical ripening	36
pcr analysis	36
differentially regulated	36
cell lysates	36
primary antibodies	36
healthy donors	36
inflamed lungs	36
randomized controlled	36
antibody response	36
mitochondrial membrane	36
serum creatinine	36
one day	36
previously demonstrated	36
molecular mechanism	36
evaluated using	36
cytokine storm	36
cient mice	36
functional role	36
may cause	36
major cause	36
negative regulator	36
controlled trial	35
chemokine receptors	35
patients underwent	35
markedly reduced	35
odds ratio	35
previous work	35
insulin resistance	35
producing cells	35
patients showed	35
body mass	35
cells per	35
major surgery	35
small molecule	35
significantly enhanced	35
possible role	35
normal range	35
lymphoid tissue	35
severe head	35
induced cell	35
three patients	35
human neutrophils	35
group received	35
one year	35
dependent signaling	35
intracellular ca	35
induced ards	35
per day	35
intestinal mucosa	35
induced tnf	35
actin cytoskeleton	35
living cells	35
high level	35
patients required	35
lupus erythematosus	35
tract infection	35
protein kinases	35
mice exhibited	35
cx cr	35
laboratory animals	35
tissue oxygenation	34
artery catheter	34
acute myocardial	34
significant increases	34
two hours	34
cerebral artery	34
may affect	34
square test	34
significantly attenuated	34
neutrophil migration	34
signaling molecules	34
hours later	34
injury induced	34
fusion protein	34
care patients	34
precursor cells	34
year old	34
transient receptor	34
treatment groups	34
receptor potential	34
treated group	34
inflammatory activity	34
glasgow coma	34
plasma samples	34
leukocyte adhesion	34
studies show	34
teaching hospital	34
mechanical stretch	34
lymph node	34
microglia activation	34
clinical symptoms	34
mediated signaling	34
leading cause	34
microarray analysis	34
oral administration	34
tlr ligand	34
severe trauma	34
low concentrations	34
superoxide dismutase	34
tissue sections	34
expression analysis	34
identified using	34
heart surgery	34
using elisa	34
hela cells	34
human macrophages	34
intravital microscopy	34
xanthine oxidase	34
cells stimulated	34
well established	34
animals treated	33
protein coupled	33
stress response	33
tight junction	33
membrane protein	33
mouse lung	33
positive bacteria	33
syncytial virus	33
normal saline	33
kinase inhibitor	33
neural stem	33
dysfunction syndrome	33
cytokines il	33
luciferase reporter	33
experimental models	33
mass index	33
data suggests	33
lower levels	33
acquired pneumonia	33
different concentrations	33
serum il	33
bal fluid	33
mg protein	33
promoter region	33
serum samples	33
survival time	33
data showed	33
first step	33
lung sections	33
pl synthesis	33
plasma concentration	33
remained unchanged	33
respiratory syncytial	33
type iii	32
results indicated	32
hla class	32
multiple trauma	32
marked increase	32
complement system	32
organ damage	32
pathway analysis	32
study suggests	32
coagulation factors	32
estrogen receptor	32
blood lactate	32
one week	32
reverse transcription	32
connective tissue	32
gene silencing	32
neuronal activity	32
cell functions	32
carotid artery	32
artery bypass	32
inflammatory disease	32
jugular vein	32
frequently used	32
rat brain	32
freshly isolated	32
polymicrobial sepsis	32
mouse line	32
low molecular	32
data collection	32
inflammatory disorders	32
blood vessel	32
activated macrophages	32
university school	32
lung surfactant	32
expression patterns	32
poor prognosis	32
therapeutic agents	32
quantified using	32
induced sepsis	32
fisher scientific	32
clinical study	32
inflammatory factors	32
also shown	32
stimulated pbmc	32
healthy individuals	32
natriuretic peptide	32
culture supernatants	32
drug delivery	32
animal care	32
patients developed	32
blood levels	32
lps induces	32
also demonstrated	31
cell numbers	31
mouse lungs	31
average age	31
different levels	31
early pregnancy	31
marrow cells	31
signaling cascade	31
liver diseases	31
atrial fibrillation	31
following treatment	31
cell suspensions	31
negative predictive	31
infected patients	31
severity score	31
pathological conditions	31
endothelial activation	31
arachidonic acid	31
histological analysis	31
splenic ultrasound	31
endotracheal tube	31
underlying mechanism	31
adult mice	31
thermal injury	31
oral insulin	31
first line	31
stroke volume	31
melanoma cells	31
mean sd	31
lg ml	31
male mice	31
pulmonary endothelial	31
transcript levels	31
medical school	31
stranded rna	31
largely unknown	31
weeks old	31
glycyrrhizic acid	31
herpes simplex	31
hospital cardiac	31
expression profile	31
folic acid	31
tlr agonist	31
mammalian cells	31
trend towards	31
lps alone	31
lpeg sirna	31
control study	31
second messenger	31
icu length	30
may influence	30
phagocytic cells	30
adrenergic receptor	30
injury severity	30
two days	30
therapeutic approaches	30
inflammasome activation	30
intracellular calcium	30
cardiopulmonary bypass	30
treated patients	30
mutant mice	30
ng glia	30
human endometrial	30
patients may	30
dependent activation	30
guinea pig	30
partial pressure	30
mean value	30
capillary permeability	30
energy metabolism	30
expression profiling	30
vitro assays	30
lysis buffer	30
cytotoxic effects	30
assay kit	30
opc differentiation	30
dorsal root	30
three independent	30
cellular immune	30
total cell	30
conditioned medium	30
wildtype mice	30
including il	30
associated pneumonia	30
related genes	30
rabbit polyclonal	30
blood monocytes	30
induced increase	30
patients requiring	30
systolic blood	30
within minutes	30
cellular uptake	30
highly conserved	30
general hospital	30
middle cerebral	30
negative controls	30
ct scan	30
highly significant	30
probably due	30
antibiotic treatment	30
cell membranes	30
times higher	30
mapk signaling	30
cells via	30
bacterial endotoxin	30
injected intraperitoneally	30
better understand	30
different stages	30
proinflammatory mediators	30
tissue repair	30
cultured human	30
studies demonstrated	30
mammary gland	30
group showed	30
apoptotic cell	30
receiver operating	29
eoc cells	29
human placenta	29
activated neutrophils	29
decision making	29
polyclonal antibody	29
mediated immune	29
using specific	29
total body	29
inflammatory reactions	29
murine macrophages	29
systematic review	29
per well	29
coma scale	29
tested whether	29
tnf receptor	29
model system	29
conditioned media	29
results provide	29
cells within	29
nkt cell	29
cells transfected	29
vein endothelial	29
sample size	29
rna interference	29
using flow	29
factor receptor	29
almost completely	29
artery pressure	29
may serve	29
challenged mice	29
prothrombin time	29
higher incidence	29
also involved	29
induced arthritis	29
sepsis patients	29
gold standard	29
important factor	29
tight junctions	29
intestinal mucosal	29
femoral head	29
higher concentrations	29
post hoc	29
weight ratio	29
expressing cells	29
acute physiology	29
randomly assigned	29
factors associated	29
butanol extract	29
regulated genes	29
mediated activation	29
low doses	29
clinical use	29
prospectively studied	29
endothelial glycocalyx	29
antibody responses	29
hours post	29
deficient cells	29
bile acids	29
dna adducts	29
flow rate	29
liquid chromatography	29
glial cell	29
considered statistically	29
studies indicate	29
negative correlation	29
fungal infections	29
recently shown	29
significant improvement	29
reduced expression	29
dna methylation	29
abdominal sepsis	29
vascular endothelium	29
gastrointestinal bleeding	29
medical records	29
gas analysis	29
continuous infusion	29
serum lactate	28
data provide	28
seven days	28
host cell	28
new insights	28
activated receptor	28
ulcerative colitis	28
dependent pathway	28
guinea pigs	28
fetal plasma	28
present work	28
human cd	28
differ significantly	28
also reduced	28
cells play	28
phagocytic activity	28
deleterious effects	28
recent data	28
matched controls	28
study demonstrated	28
adult respiratory	28
corticosteroid treatment	28
increased susceptibility	28
inflammatory signaling	28
gene promoter	28
constitutively expressed	28
decidual cells	28
cardiac fibroblasts	28
inflammatory protein	28
glioma cells	28
negative bacterial	28
human keratinocytes	28
secretory phase	28
data set	28
granulosa cells	28
significantly correlated	28
expression data	28
recent study	28
ttp myeko	28
target gene	28
cytokines tnf	28
antigen processing	28
plasma volume	28
like cells	28
ml vs	28
immune function	28
lamina propria	28
listeria monocytogenes	28
public health	28
whitney test	28
normal pregnancy	28
follicular fluid	28
fetal bovine	28
optic nerve	28
study provides	28
serine protease	28
day post	28
wide variety	28
binding activity	28
gap junction	28
prospective cohort	28
simplex virus	28
receptor agonist	28
old male	28
significant role	28
chest pain	28
lung metastasis	28
bronchial epithelial	27
hematopoietic cells	27
mean apache	27
using anti	27
cellular processes	27
patient safety	27
neonatal rat	27
survival rates	27
markedly increased	27
may indicate	27
parenteral nutrition	27
cerebral endothelial	27
liver damage	27
blood donors	27
increased production	27
inhibitory activity	27
fio ratio	27
cytometric analysis	27
independently associated	27
metabolic pathways	27
body surface	27
confidence interval	27
diagnostic criteria	27
intracranial pressure	27
pct levels	27
lps ifn	27
severity scores	27
porcine reproductive	27
trpc channels	27
recently demonstrated	27
might contribute	27
goat anti	27
receptor antagonists	27
antimicrobial activity	27
showed significantly	27
combination therapy	27
phase ii	27
villous explants	27
results demonstrated	27
study included	27
oxygen tension	27
cirrhotic patients	27
human blood	27
early stages	27
two distinct	27
dependent protein	27
fungal infection	27
shock protein	27
paraffin embedded	27
mean duration	27
burn injury	27
allergic asthma	27
human serum	27
shear stress	27
graphpad prism	27
lpz mpsl	27
recent evidence	27
proteins involved	27
high expression	27
chronic pain	27
tract infections	27
independent risk	27
challenged wt	27
oxygen extraction	27
mitochondrial dysfunction	27
elisa kits	27
high mobility	27
evaluate whether	27
signaling via	27
neurological outcome	27
large amounts	27
chi square	27
present data	27
human endometrium	27
two types	27
data support	27
general icu	27
inflammatory mediator	26
statistical analyses	26
cruz biotechnology	26
pulmonary infection	26
fetal sheep	26
anova followed	26
controlled study	26
intestinal inflammation	26
injury model	26
ms lesions	26
much higher	26
cardiovascular diseases	26
improved survival	26
increasing concentrations	26
mice infected	26
jugular bulb	26
sepsis model	26
non invasive	26
fluorescent protein	26
recently identified	26
respiratory signs	26
showed increased	26
dependent increase	26
nursing staff	26
increasing evidence	26
dna binding	26
expression may	26
group iii	26
using spss	26
patients compared	26
carbon dioxide	26
cellular response	26
surviving sepsis	26
fetal lung	26
negative sepsis	26
single dose	26
anp low	26
comet assay	26
increased compared	26
secondary antibodies	26
cell interactions	26
previous findings	26
experimental autoimmune	26
following parameters	26
statistically different	26
neutrophil activation	26
study investigated	26
quantitative analysis	26
died within	26
broad spectrum	26
recipient mice	26
pathways involved	26
neuronal cells	26
use committee	26
cells compared	26
surfactant lipids	26
kupffer cell	26
protects mice	26
host defence	26
lung compliance	26
rat lung	26
steady state	26
experimental conditions	26
antimicrobial peptides	26
mouse macrophages	26
induced pulmonary	26
including tnf	26
nerve injury	26
study aims	26
naturally occurring	26
ten patients	26
high frequency	25
regression model	25
genomic dna	25
increased il	25
human myometrial	25
airway management	25
human health	25
intestinal ischemia	25
effective treatment	25
rough lps	25
cold pbs	25
decreased expression	25
acid residues	25
enzymatic activity	25
fluorescence intensity	25
bacterial clearance	25
results suggested	25
persistent pulmonary	25
per se	25
membrane oxygenation	25
vivo model	25
mdck cells	25
also expressed	25
remains unknown	25
cellular responses	25
molecular biology	25
autoimmune disease	25
kg i	25
results may	25
well understood	25
marginated neutrophils	25
receptor complex	25
significantly suppressed	25
autoimmune encephalomyelitis	25
clinical features	25
therapeutic approach	25
brain damage	25
days following	25
positive blood	25
play important	25
experiments revealed	25
experimental group	25
bacterial growth	25
bovine lactoferrin	25
antithrombin iii	25
chronic lung	25
via tlr	25
irg cad	25
drug development	25
following trauma	25
two major	25
mice deficient	25
abdominal pain	25
invasive mechanical	25
grey matter	25
oxide production	25
support ventilation	25
induced septic	25
normal pregnancies	25
treated controls	25
also present	25
tyrosine phosphorylation	25
mediated immunity	25
maternal plasma	25
injury score	25
cells following	25
barrier dysfunction	25
brain death	25
therapeutic interventions	25
overall mortality	25
induced tlr	25
see table	25
inhalation injury	25
biologically active	25
dna vaccine	25
biological effects	25
food intake	25
much lower	25
research institute	25
correlation coefficient	25
late gestation	25
experimental animals	25
detected using	25
strongly suggest	25
therapeutic effects	25
dna double	25
airway epithelial	25
potential target	25
barrier integrity	25
maternal age	25
arterial oxygen	25
experimental studies	25
well defined	25
chronic hepatitis	25
lesser extent	24
myeloid differentiation	24
pregnant mice	24
early postoperative	24
may occur	24
circulating levels	24
tissue culture	24
first study	24
cerebrospinal fluid	24
specific antibody	24
control subjects	24
cell recruitment	24
palliative care	24
conjugated anti	24
fluid balance	24
also performed	24
double strand	24
cell sorting	24
without affecting	24
intrauterine growth	24
activator inhibitor	24
human disease	24
mice expressing	24
cross talk	24
applied biosystems	24
cycle progression	24
adenylate cyclase	24
synaptic plasticity	24
test whether	24
target proteins	24
demyelinated axons	24
cells derived	24
neuronal death	24
increased pulmonary	24
human monocyte	24
tlr md	24
lineage cells	24
human pulmonary	24
single nucleotide	24
fi rst	24
spleen cells	24
lactic acid	24
monocyte macrophage	24
significant effect	24
one hundred	24
matrix metalloproteinases	24
seven patients	24
prognostic factors	24
fetal weight	24
primary antibody	24
supine position	24
enteral nutrition	24
interquartile range	24
patients presented	24
concentration range	24
cells expressed	24
immune complex	24
medical history	24
new york	24
clinical characteristics	24
cells ml	24
animals received	24
serum amyloid	24
nosocomial infection	24
cerebral blood	24
blood circulation	24
disease activity	24
also used	24
irg expression	24
obstetrics gynecology	24
one case	24
hepatitis patients	24
schwann cell	24
liver tissue	24
medical intensive	24
phase proteins	24
induced dna	24
study conducted	24
inflammatory lung	24
immunoblot analysis	24
patient care	24
colon cancer	24
specific immune	24
trophoblast cell	24
dependent mechanism	24
tnf levels	24
human cells	24
mm nacl	24
per patient	24
coagulation system	24
four patients	24
calculated using	24
tertiary care	24
genes encoding	24
high incidence	23
elisa kit	23
paraffin sections	23
published data	23
inflammatory genes	23
septic complications	23
liver cells	23
initial dose	23
functional changes	23
among others	23
promising therapeutic	23
gene regulation	23
analysis demonstrated	23
might also	23
candidate genes	23
give rise	23
consecutive days	23
kidney disease	23
injured patients	23
primary cultures	23
oligodendrocyte precursor	23
first week	23
infectious disease	23
long time	23
bowel necrosis	23
adult male	23
median time	23
ultrasound treatment	23
examined whether	23
inhibited lps	23
acute brain	23
mouse brain	23
whole body	23
tir domain	23
lipid rafts	23
postoperative day	23
matrix metalloproteinase	23
observation period	23
humoral immune	23
derived cells	23
lung damage	23
protein interactions	23
growth hormone	23
glucose tolerance	23
mediated inhibition	23
stably transfected	23
edema formation	23
experimental groups	23
specific inhibitors	23
cd antibody	23
also measured	23
cells also	23
useful tool	23
multiple comparisons	23
virus infections	23
general anesthesia	23
respiratory mechanics	23
gnrh ii	23
different groups	23
protective immunity	23
fold change	23
femoral artery	23
induced production	23
miu ml	23
induced colitis	23
granulocyte colony	23
antibody production	23
ace activity	23
ng kg	23
aea levels	23
via activation	23
newborn offspring	23
allergic inflammation	23
receptor family	23
mice challenged	23
mice displayed	23
cells well	23
sofa scores	23
still unknown	23
intestinal injury	23
using standard	23
might play	23
major abdominal	23
phosphate buffer	23
urine samples	23
ca influx	23
receptor signalling	23
lung vascular	23
baseline characteristics	23
dose response	23
wet dry	23
different mechanisms	23
mouse monoclonal	23
mechanism underlying	23
increased vascular	23
immunohistochemical staining	23
experiments using	23
intravenous administration	23
extracellular space	23
adaptor protein	23
common complication	23
ventilatory support	23
delivery system	23
steroid hormones	23
may improve	22
er stress	22
mhc i	22
null mice	22
analyses revealed	22
phase protein	22
emergency room	22
primary tumor	22
pge production	22
cns inflammation	22
lymphocyte proliferation	22
intracranial hypertension	22
phase i	22
trizol reagent	22
inflammatory pathways	22
lung fibroblasts	22
fl fl	22
acute exacerbations	22
itaconic acid	22
allergic airway	22
sepsis campaign	22
cell activity	22
vivo experiments	22
mucosal barrier	22
membrane proteins	22
tipe overexpression	22
syndrome virus	22
hemodynamic changes	22
collagen deposition	22
primary mouse	22
surface receptors	22
gene therapy	22
cell specific	22
lung collectins	22
full length	22
soluble tnf	22
hypoxic pulmonary	22
infectious complications	22
patient outcome	22
assay using	22
function tests	22
mediated gene	22
channel activity	22
i min	22
animal testing	22
among women	22
local inflammatory	22
lp group	22
serum tnf	22
positive staining	22
mean sem	22
baseline values	22
cultured astrocytes	22
density gradient	22
nerve fibers	22
transduction pathway	22
mature oligodendrocytes	22
cell damage	22
erk activation	22
cd monocytes	22
pasteurella multocida	22
liquid nitrogen	22
least three	22
myeloid cell	22
showed similar	22
tnf alpha	22
whole genome	22
alveolar macrophage	22
factors may	22
pam csk	22
tlr stimulation	22
higher risk	22
table shows	22
bordetella bronchiseptica	22
four groups	22
cytokine gene	22
cell transformation	22
serum concentrations	22
well characterized	22
tail vein	22
will provide	22
atopic dermatitis	22
cholera toxin	22
metabolic alkalosis	22
adoptive transfer	22
ventricular function	22
competing interests	22
intestinal epithelium	22
may reflect	22
acid use	22
mice fed	22
way analysis	22
scavenger receptor	22
vibrating mesh	22
extracorporeal membrane	22
marrow derived	22
rats subjected	22
two cases	22
molecule expression	22
cells exposed	22
clinical conditions	22
receptor mrna	22
vena cava	21
kinase activity	21
infectious agents	21
studies revealed	21
breathing pattern	21
helicobacter pylori	21
septic mice	21
physiological role	21
also suggest	21
common cause	21
induced phosphorylation	21
cord injury	21
septic animals	21
cognitive impairment	21
signalling molecules	21
medical centre	21
respiratory alkalosis	21
case report	21
prospectively collected	21
macrophage inflammatory	21
drug administration	21
calcium channel	21
brain slices	21
molecular basis	21
treatment significantly	21
placental tissue	21
camp levels	21
adaptor proteins	21
response element	21
surgery patients	21
cardiac dysfunction	21
human uterine	21
severe liver	21
higher level	21
uterine emg	21
human placental	21
factors including	21
sybr green	21
horseradish peroxidase	21
also able	21
protein content	21
rank test	21
induced changes	21
blood transfusions	21
rats treated	21
repeated measures	21
receptor binding	21
icu staff	21
hepatic failure	21
active form	21
allowed us	21
oxygen therapy	21
healthy control	21
also induced	21
dominant negative	21
inflammatory changes	21
polyclonal antibodies	21
surgical intensive	21
vascular dilatation	21
ic bps	21
sensory neurons	21
experimental data	21
intravascular volume	21
results support	21
right ventricle	21
normal controls	21
lung cells	21
may act	21
completely abolished	21
mice injected	21
defense mechanisms	21
mm tris	21
various inflammatory	21
lung wet	21
artery occlusion	21
hepg cells	21
ischemic injury	21
density lipoprotein	21
final concentration	21
vs control	21
muscle cell	21
transcriptional activity	21
nosocomial infections	21
invading pathogens	21
tumor development	21
also tested	21
basal level	21
associated lymphoid	21
ligand binding	21
electrical activity	21
enhanced expression	21
clotting factors	21
vascular leakage	21
mm edta	21
inhaled nitric	21
despite enhanced	21
ii scores	21
cultured cells	21
murine models	21
patients hospitalized	21
following injury	21
low pmn	21
lps binding	21
blood sampling	21
effects may	21
fold lower	21
hospital length	21
improve survival	21
one hand	21
i receptor	21
i levels	21
human fetal	21
respiratory epithelium	21
regulatory mechanisms	21
ge healthcare	21
assess whether	21
postoperative complications	21
pelvic organ	21
relatively low	21
polyacrylamide gel	21
second lps	21
may increase	21
cells isolated	21
risk patients	21
lung infl	21
patients presenting	21
venous catheter	20
sialic acid	20
placebo group	20
induced neutrophil	20
injured mice	20
induced nf	20
main cause	20
nuclear protein	20
written informed	20
physiological functions	20
rat liver	20
mtt assay	20
patient population	20
active site	20
wedge pressure	20
oxygen transport	20
operating characteristic	20
care bundle	20
guanylate cyclase	20
patients included	20
day survival	20
key factor	20
sodium dodecyl	20
oxygen free	20
general population	20
vital signs	20
icu admissions	20
control values	20
caesarean section	20
fully understood	20
hospital admission	20
using high	20
lps elastase	20
bacterial products	20
lung endothelial	20
reduced levels	20
within one	20
left ventricle	20
vitro methods	20
various types	20
human heart	20
tested using	20
complex i	20
alexa fluor	20
neutralizing antibodies	20
interstitial edema	20
cell injury	20
antimicrobial therapy	20
lc ms	20
meconium passage	20
onset preeclampsia	20
oxygen radicals	20
chronic pelvic	20
virus replication	20
primary microglia	20
inspiratory pressure	20
iu ml	20
plasmid dna	20
analysis indicated	20
three weeks	20
neonatal mice	20
multiorgan failure	20
hcv infection	20
deficient pmcs	20
sepsis induced	20
superoxide production	20
ra patients	20
blood products	20
extracellular signal	20
protein sp	20
lps treated	20
pregnancy outcome	20
post infection	20
cardiac myocytes	20
sepsis group	20
gene encoding	20
joint inflammation	20
selective inhibition	20
levels may	20
hyaluronic acid	20
rabbit igg	20
carcinoma cells	20
developmental stages	20
will also	20
mice using	20
four hours	20
ii cells	20
cellular stress	20
vitro models	20
specific binding	20
cognitive decline	20
currently available	20
pulmonary vasoconstriction	20
likely due	20
using trizol	20
conjugated secondary	20
positive effect	20
lymphoid organs	20
treated groups	20
induced vascular	20
luteal cells	20
complement factor	20
maternal blood	20
chronic disease	20
mainly due	20
study population	20
organ system	20
severe disease	20
within min	20
breast milk	20
higher expression	20
untreated cells	20
least two	20
regulatory role	20
mediated inflammation	20
neuronal cell	20
clostridium difficile	20
increased activity	20
also assessed	20
rac nitration	20
remained stable	20
two cell	20
isolated using	20
green fluorescent	20
histological examination	20
lactation period	20
related protein	20
vivo data	20
less pronounced	20
infected individuals	19
right lung	19
transcriptional regulators	19
increased permeability	19
protease inhibitors	19
plasma aea	19
negative feedback	19
hoc test	19
primary rat	19
monocyte chemoattractant	19
life support	19
novel mechanism	19
elective cesarean	19
animals showed	19
immune tolerance	19
inflammatory drugs	19
cell transplantation	19
protein complex	19
expression changes	19
antibodies directed	19
still remains	19
will focus	19
past years	19
pulmonary pathology	19
term outcome	19
hematopoietic stem	19
tlr gene	19
silver nanoparticles	19
potent inhibitor	19
increased blood	19
unclear whether	19
core temperature	19
bacterial sepsis	19
every day	19
took place	19
luciferase activity	19
relatively high	19
respiratory insufficiency	19
cerebral ischemia	19
plasma tnf	19
alternative pathway	19
tnf receptors	19
mice exposed	19
lethal dose	19
palm expression	19
transmission electron	19
bacterial cell	19
per ml	19
also investigated	19
oligodendrocyte progenitor	19
year mortality	19
thrombin generation	19
male offspring	19
collected data	19
activation markers	19
burned patients	19
i ifn	19
inotropic support	19
irf activity	19
reverse transcriptase	19
vivo models	19
endotoxin induced	19
angiotensin converting	19
colorectal cancer	19
change significantly	19
action potential	19
imperial college	19
normal values	19
important mediator	19
colon carcinoma	19
cell maturation	19
undergoing cardiac	19
perfusion pressure	19
small molecules	19
particle size	19
platelet activating	19
every hours	19
human brain	19
randomly divided	19
propidium iodide	19
induced airway	19
energy expenditure	19
glutamate uptake	19
still unclear	19
endotracheal intubation	19
days prior	19
transcriptional level	19
neurite outgrowth	19
recently described	19
tlr signalling	19
care med	19
protein assay	19
endotoxemic mice	19
endothelial function	19
septic response	19
mitogen activated	19
clinical parameters	19
western blots	19
mg day	19
costimulatory molecules	19
using different	19
lung water	19
disease patients	19
euglena tuba	19
intravenous infusion	19
cell tolerance	19
flow cytometer	19
receptor protein	19
plasma endotoxin	19
coagulation cascade	19
patients following	19
reproductive sciences	19
primary cultured	19
also inhibited	19
hours following	19
regulatory proteins	19
nine patients	19
hypovolemic shock	19
monocytic cells	19
also revealed	19
showed higher	19
equal amounts	19
intracellular camp	19
test system	19
cd cell	19
showed high	19
white cell	19
corpus callosum	19
recently reported	19
tlr mrna	19
light microscope	19
may suggest	19
phase response	19
higher rate	19
epidemiological studies	19
adverse outcomes	19
lung transplantation	19
chart review	19
weeks post	19
placental abruption	19
pertussis toxin	19
bacterial lps	19
serum concentration	19
preterm labour	19
base excess	19
may induce	19
pulmonary rehabilitation	19
diseases including	19
mechanisms responsible	19
chemoattractant protein	19
genetic background	19
microvascular permeability	19
one patients	19
shed blood	19
tissue inflammation	19
phosphorylation sites	19
may therefore	19
therapeutic agent	19
vitro stimulation	19
inflammasome pathway	19
potassium channels	19
selectin expression	19
proliferative response	19
alternative splicing	19
vast majority	19
biological processes	19
will help	19
situ hybridization	19
biological activities	19
also evaluated	19
intracellular signaling	19
vagus nerve	19
equal volume	19
culture conditions	19
major component	18
aki stage	18
derived dendritic	18
ml saline	18
graphpad software	18
mesenteric arteries	18
newly developed	18
eight patients	18
concentration dependent	18
pol ii	18
risk stratification	18
plasma il	18
right heart	18
slight increase	18
experimental sepsis	18
science foundation	18
pg kg	18
significant association	18
intubated patients	18
one group	18
refractory ascites	18
neutrophilic inflammation	18
cd foxp	18
tandem mass	18
lactate dehydrogenase	18
evidence indicates	18
adult rats	18
ards mice	18
stimulated macrophages	18
previous results	18
bacterial peritonitis	18
provide new	18
fetal dna	18
cytotoxic effect	18
expressing cd	18
mesenteric lymph	18
remain unclear	18
expiratory flow	18
whole cell	18
traumatic injury	18
tlr ko	18
optical density	18
macrophage polarization	18
cfhr deletion	18
prrsv infection	18
isotype control	18
pharmacological inhibition	18
smooth lps	18
relative expression	18
neonatal outcomes	18
effector functions	18
green tea	18
identifi ed	18
degradation products	18
isolated human	18
inhibits lps	18
cell morphology	18
ringo spy	18
crystal structure	18
ammatory response	18