trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
the presence of	399
as well as	293
the treatment of	232
the synthesis of	217
a series of	215
in order to	191
of the compounds	179
found to be	177
in the presence	174
the development of	173
of mannich bases	166
mannich bases of	160
of these compounds	157
based on the	152
one of the	149
the most potent	149
according to the	136
a number of	129
for the treatment	129
was found to	122
mechanism of action	122
activity of the	119
the use of	118
the activity of	113
compared to the	112
the most active	107
due to the	105
on the other	105
more potent than	104
as compared to	101
the other hand	101
a and b	101
the formation of	99
to that of	99
in vitro and	97
for the synthesis	96
position of the	96
the active site	93
cancer cell lines	91
than that of	90
of the compound	89
the compounds were	88
bases derived from	88
the case of	88
were found to	87
in the case	87
of the most	87
in this study	86
mannich bases derived	85
the mechanism of	85
and in vivo	81
synthesis and biological	80
the number of	79
antiviral activity of	78
the inhibition of	77
vitro and in	76
and biological evaluation	76
as shown in	74
the discovery of	73
in the treatment	73
it has been	73
in the range	72
of action of	71
phenolic mannich bases	71
biological evaluation of	71
most of the	70
was carried out	70
to be the	69
the production of	69
at room temperature	68
by means of	68
the antiviral activity	68
at position of	68
a variety of	67
antiviral activity against	67
the range of	66
used as a	65
and in vitro	64
and evaluation of	64
presence of a	63
the effect of	63
antifungal activity of	63
acute respiratory syndrome	61
in addition to	61
to be a	61
severe acute respiratory	61
analysis of the	60
the structure of	59
with ic values	58
the growth of	58
responsible for the	58
structure of the	58
presence of the	58
the introduction of	57
some of the	57
was used as	57
isolated from the	57
well as the	57
the mannich reaction	57
inhibitory activity against	56
wide range of	56
the results of	56
the most promising	55
involved in the	55
these compounds were	54
the importance of	54
of reference drug	54
were carried out	54
as a result	53
antibacterial activity of	53
was treated with	53
led to the	53
the tested compounds	53
the preparation of	52
ic values of	52
mode of action	52
the design of	52
metabolic pathway classes	52
evaluation of the	52
than reference drug	52
the nature of	51
was the most	51
in the same	51
due to their	51
activity of mannich	50
crystal structure of	50
proved to be	50
a wide range	49
the evaluation of	49
the reaction mixture	48
activity against the	48
the role of	47
for the development	47
in terms of	47
as amine reagents	47
at the c	47
mechanisms of action	47
the ability to	47
at a concentration	46
used in the	46
of the enzyme	46
in this series	46
to give compound	46
herpes simplex virus	46
inhibitors of the	45
to inhibit the	45
the ability of	45
to evaluate the	45
showed that the	45
active site of	45
shown to be	45
have been reported	44
of broccoli sprouts	44
that of the	44
it was found	44
to the general	43
that of reference	43
the antibacterial activity	43
the fact that	43
suggested that the	43
the in vitro	43
antimicrobial activity of	43
synthesis and in	43
the reaction of	43
in vitro activity	43
and characterization of	43
for h at	42
nature of the	42
the majority of	42
inhibitory activity of	42
can be used	42
the search for	42
were the most	42
a mixture of	42
a concentration of	42
as inhibitors of	41
related to the	41
then purified by	41
used for the	41
was shown to	41
new class of	41
is one of	41
was used to	41
the aromatic ring	41
to determine the	41
were more potent	41
the absence of	41
the synthesized compounds	41
biological activity of	41
synthesis of novel	41
and then purified	40
has been reported	40
to reference drug	40
chromatography to give	40
was added to	40
of a series	40
due to its	40
the general procedure	39
of the protein	39
reaction mixture was	39
of compound a	39
respiratory syndrome coronavirus	39
a set of	39
activity in the	39
of the molecule	39
in patients with	39
of bioactive compounds	39
in the series	39
derivatives synthesis and	39
comparable to that	38
ketonic mannich bases	38
at the same	38
antifungal activity against	38
the efficacy of	38
large number of	38
been shown to	38
of some new	38
did not show	38
such as the	38
of mg kg	37
shown in table	37
molecular docking studies	37
was found that	37
their ability to	37
group at the	37
a range of	37
in combination with	37
the phenyl ring	37
the cells were	36
series of compounds	36
for treatment of	36
by reverse phase	36
potent inhibitors of	36
the basis of	36
in which the	36
food and drug	36
reverse phase flash	36
the biological activity	36
a panel of	36
phase flash chromatography	36
of psoralea corylifolia	36
in vitro anti	35
the side chain	35
and drug administration	35
the identification of	35
more active than	35
group of the	35
present in the	35
the concentration of	35
none of the	35
ic value of	35
of compounds a	35
activity against a	35
a result of	35
that the presence	35
general procedure a	35
purified by reverse	35
carried out by	34
a dose of	34
broccoli sprouts and	34
are known to	34
for the preparation	34
that these compounds	34
in this context	34
to the formation	34
of the ligand	34
on the basis	34
the qsar model	34
flash chromatography to	34
all of the	34
has also been	34
of a new	34
at a dose	33
evaluated for their	33
in the last	33
a solution of	33
synthesized a series	33
sprouts and microgreens	33
observed in the	33
of the test	33
results showed that	33
as amine reagent	33
some of these	33
inhibition of the	32
the most common	32
mannich bases were	32
the detection of	32
these compounds are	32
a decrease in	32
the percentage of	32
the addition of	32
the ebola virus	32
the mixture was	32
were used as	32
to be more	32
the ic values	32
of the tested	32
secondary aliphatic amines	32
be able to	32
activity of these	32
with the exception	32
compounds were evaluated	32
based on a	32
because of the	32
which is a	32
the cytotoxicity of	31
the first time	31
compounds were tested	31
for the first	31
and its derivatives	31
carried out using	31
known to be	31
as the most	31
added to the	31
it is worth	31
in the mannich	31
the expression of	31
binding free energy	31
the effects of	31
were shown to	31
the level of	31
potent than reference	31
was purified by	31
dose of mg	31
and biological activity	31
development of new	31
mannich bases and	31
of a novel	30
in medicinal chemistry	30
resulted in the	30
were evaluated for	30
ic values in	30
able to inhibit	30
synthesized and evaluated	30
human immunodeficiency virus	30
similar to that	30
with an ic	30
properties of the	30
effect on the	30
all the compounds	30
antibacterial activity against	30
found in the	30
and synthesis of	30
was used for	30
a large number	30
the replication of	30
central nervous system	30
the exception of	30
shown in figure	30
which can be	30
compounds a and	30
be the most	30
of coumarin derivatives	30
values in the	30
the results showed	29
treated with n	29
study of the	29
in the synthesis	29
in this case	29
interaction with the	29
be considered as	29
of the same	29
replacement of the	29
marine natural products	29
associated with the	29
of the two	29
ability to inhibit	29
activity of a	29
are shown in	29
the interaction between	29
compounds in the	29
resulted in a	29
with respect to	29
the interaction of	29
this class of	29
in the aminomethyl	29
biological activities of	29
were synthesized and	28
in this work	28
each of the	28
van der waals	28
lower than that	28
is the most	28
an increase in	28
of the cell	28
of the corresponding	28
results indicated that	28
it was observed	28
the selected compounds	28
were used to	28
based virtual screening	28
of the active	28
were infected with	28
amino acid residues	28
results suggest that	28
of biological activities	28
in comparison to	28
was subjected to	28
a new class	28
been reported to	28
synthesis and evaluation	28
the series of	27
activity of some	27
there is a	27
the test compounds	27
the antifungal activity	27
to the activity	27
when compared to	27
it should be	27
cov cl pro	27
decrease in the	27
shown that the	27
it was shown	27
derived from the	27
and related compounds	27
different concentrations of	27
hepatitis c virus	27
were treated with	27
to increase the	27
was able to	27
in the present	27
the synthesis and	27
for these compounds	27
in the active	26
the h nmr	26
activity of compounds	26
an ic value	26
the structures of	26
led to a	26
of the human	26
studies on the	26
interactions with the	26
the crystal structure	26
series of mannich	26
of influenza virus	26
at mg kg	26
have shown that	26
of the antibiotic	26
part of the	26
was performed using	26
developed for the	26
potent and selective	26
it is a	26
antioxidant activity of	26
a novel series	26
were added to	26
for the design	26
novel series of	26
of the molecules	25
design and synthesis	25
be used as	25
be used to	25
used as the	25
hepatitis b virus	25
point of view	25
in the first	25
activity compared to	25
the mode of	25
and antimicrobial activity	25
found that the	25
compared with the	25
one or more	25
compounds and were	25
the reference drug	25
the study of	25
dopamine d receptor	25
as a potential	25
double mannich bases	25
search for new	25
the application of	25
of the virus	25
obtained from the	25
evaluation of novel	25
shown in scheme	25
showed the highest	25
and antiviral activity	25
is able to	25
the context of	24
of the synthesized	24
compounds with the	24
the binding site	24
site of the	24
synthesis of new	24
tuberculosis h rv	24
found to have	24
of the series	24
increase in the	24
suggests that the	24
in the literature	24
was dissolved in	24
synthesis of coumarin	24
in some cases	24
conflict of interest	24
modification of the	24
of compounds with	24
to those of	24
compounds were also	24
results of the	24
influenza a virus	24
the results indicated	24
the position of	24
value of the	24
the value of	24
respiratory syncytial virus	24
changes in the	24
concentrations of the	24
considered to be	23
values ranging from	23
the potency of	23
the compounds with	23
has not been	23
to be active	23
was determined by	23
class of compounds	23
against a panel	23
i and ii	23
the results were	23
in a similar	23
the binding pocket	23
of the reaction	23
have been used	23
evaluation of their	23
interaction between the	23
of the viral	23
role in the	23
compound was treated	23
concentration of the	23
to study the	23
the most effective	23
this study was	23
synthesis and antimicrobial	23
against hepg cells	23
studies showed that	23
the same time	23
designed and synthesized	23
effect of the	23
compounds have been	23
were tested against	23
the release of	23
in the study	23
corresponding to the	23
the activity against	23
most active compound	23
as in the	23
the potential to	23
in the absence	23
have also been	23
synthesized compounds were	23
of some novel	23
ix and xii	23
development of a	23
the analysis of	23
an important role	23
use of the	23
it is also	23
of the binding	23
has been used	23
qsar model obtained	22
hepg cells and	22
active than the	22
isatis tinctoria l	22
was shown that	22
substitution of the	22
no conflict of	22
in vivo and	22
that can be	22
to investigate the	22
is based on	22
for the detection	22
a total of	22
structures of the	22
the standard drug	22
in vitro evaluation	22
compared to reference	22
important for the	22
of all the	22
higher than that	22
the control of	22
described in the	22
a and a	22
the compounds was	22
ability of the	22
the reaction was	22
to assess the	22
of the triazole	22
less potent than	22
were able to	22
antitumor activity of	22
mixture was stirred	22
the most important	22
potent inhibitor of	22
have been shown	22
activities of some	22
synthesis and anti	22
and inhibition of	22
the type of	22
of compound with	22
positive and gram	22
of the interaction	22
the binding of	22
synthesis of some	22
depending on the	22
respect to the	22
in the search	22
in the context	22
attributed to the	21
broad spectrum of	21
united states food	21
method for the	21
a broad spectrum	21
group at position	21
these compounds have	21
and antimicrobial activities	21
in broccoli sprouts	21
is involved in	21
antimicrobial activities of	21
for further development	21
and of the	21
and antiviral activities	21
importance of the	21
mg kg day	21
compared to that	21
antiviral activity was	21
range of biological	21
b and c	21
a review of	21
activity in vitro	21
inhibitory effect on	21
of the drug	21
evaluation of some	21
been found to	21
of natural products	21
could be used	21
emerged as the	21
these mannich bases	21
of the indole	21
anticonvulsant activity of	21
the activation of	21
the lack of	21
region of the	21
the replacement of	21
compound in the	21
in cell culture	21
varicella zoster virus	21
the authors declare	21
many of the	21
at least one	21
inflammatory activity of	21
in the development	21
states food and	21
to afford the	21
reaction of with	21
tested for their	21
of the new	21
the risk of	21
of secondary metabolites	21
a view to	21
the amino group	21
seems to be	21
activity of novel	21
removal of the	21
with a view	21
as shown by	21
all of these	21
is a potent	21
have been synthesized	21
cl pro inhibitors	21
it may be	21
and development of	20
of the candidates	20
were tested for	20
gel column chromatography	20
the inhibitory activity	20
spectra were recorded	20
of the n	20
be responsible for	20
some of them	20
moderate to good	20
from psoralea corylifolia	20
of this class	20
concentration of compound	20
stability of the	20
and their derivatives	20
of antiviral activity	20
for use in	20
was observed for	20
for c h	20
has been shown	20
cells and mcf	20
in vivo studies	20
characterized by a	20
in comparison with	20
values of the	20
lead to the	20
to give the	20
of the c	20
cells in the	20
activities of the	20
were isolated from	20
a wide variety	20
metabolic pathway class	20
revealed that the	20
of the mannich	20
it is not	20
a positive control	20
of the starting	20
in recent years	20
in a dose	20
to be able	20
wide variety of	20
the title compound	20
in clinical trials	20
formation of a	20
agents synthesis and	20
appears to be	20
prepared compounds were	20
protein data bank	20
in the aromatic	20
formation of the	20
be used in	20
this compound was	20
it can be	20
title compound was	20
that have been	20
in the brain	20
amino group of	20
were obtained from	20
and can be	20
for which the	20
to the active	19
has been developed	19
considered as a	19
the influence of	19
synthesis of a	19
was observed in	19
for peer review	19
detected in the	19
an endophytic fungus	19
and antifungal activity	19
there is no	19
of test compounds	19
were subjected to	19
to the presence	19
worth noting that	19
peer review of	19
against the ebola	19
to reduce the	19
may be a	19
x for peer	19
of compounds were	19
by silica gel	19
indicated that the	19
of the coumarin	19
is worth noting	19
serve as a	19
of the amino	19
be used for	19
and mg ml	19
procedure for the	19
simplex virus type	19
we found that	19
to the development	19
any of the	19
binding to the	19
the fi rst	19
the reduction of	19
as a reference	19
chemical modification of	19
and the results	19
binding site of	19
members of the	19
in contrast to	19
of this compound	19
atom of the	19
carried out on	19
tumor cell lines	19
the new compounds	19
as antibacterial agents	19
to the standard	19
with ec values	19
because of their	19
incubated for h	19
and it is	19
in the human	19
less active than	19
of these candidates	19
world health organization	19
shown by eq	19
that the activity	19
orders of magnitude	19
were calculated using	19
it was suggested	19
most active compounds	18
used to treat	18
that most of	18
well as in	18
the university of	18
was prepared by	18
like protease inhibitors	18
along with the	18
of this study	18
with the active	18
compounds in this	18
middle east respiratory	18
this type of	18
and molecular docking	18
the indole ring	18
mannich bases with	18
compounds isolated from	18
carried out in	18
of the disease	18
potent than the	18
in agreement with	18
to be used	18
and the most	18
the seeds of	18
activity of compound	18
both in vitro	18
in the discovery	18
and some of	18
set of compounds	18
important role in	18
of viral replication	18
the triazole ring	18
that the compound	18
the hypothesis that	18
activity evaluation of	18
a potent inhibitor	18
the influenza virus	18
used as reference	18
all studied compounds	18
authors declare no	18
inhibitors of human	18
were determined by	18
have been identified	18
in animal models	18
selective inhibitors of	18
are able to	18
reactive oxygen species	18
at the end	18
results revealed that	18
human cancer cell	18
was evaluated against	18
to improve the	18
nmr spectra were	18
are presented in	18
a group of	18
a class of	18
silica gel column	18
in the future	18
classes of compounds	18
atoms of the	18
evaluation of a	18
was applied to	18
together with the	17
the present study	17
to the reference	17
the active compounds	17
in the control	17
were exposed to	17
amine reagents in	17
and biological activities	17
between the two	17
breast cancer cells	17
the mic values	17
candidates derived from	17
these results suggest	17
and in the	17
acts as a	17
was suggested that	17
introduction of the	17
were calculated for	17
were performed in	17
compounds with a	17
that it is	17
in the binding	17
to the discovery	17
hydrolysis of the	17
room temperature for	17
mouse model of	17
of the host	17
ec values of	17
are the most	17
new series of	17
the compound was	17
was as shown	17
and incubated for	17
the length of	17
mannich bases as	17
order to obtain	17
caused by the	17
derivatives as potential	17
of isatis tinctoria	17
linked to the	17
performed using the	17
close to the	17
vitro activity against	17
have been found	17
column chromatography using	17
were evaluated in	17
was washed with	17
the most abundant	17
discovery of a	17
the process of	17
were generally more	17
series of novel	17
of patients with	17
used in this	17
addition to the	17
in plasmodium falciparum	17
purified by silica	17
virus yield reduction	17
were used for	17
in case of	17
acyclic nucleoside phosphonates	17
vivo and in	17
seemed to be	17
bases of type	17
means of the	17
of cells in	17
shown to have	17
the end of	17
east respiratory syndrome	17
as a positive	17
was evaluated by	17
as far as	17
antimycobacterial activity of	17
potential of the	17
compounds such as	17
at the concentration	17
are involved in	17
it is possible	17
dependent rna polymerase	17
effects on the	17
anticancer activity of	17
cancer cell line	17
at concentration of	17
a combination of	17
of the aglycone	17
feline infectious peritonitis	17
were also tested	17
with the same	17
ch c h	17
similar to the	16
by the same	16
as potential anti	16
reaction of a	16
be involved in	16
the results obtained	16
indicating that the	16
and in silico	16
to prevent the	16
cells were treated	16
the loss of	16
evaluated in vitro	16
mice treated with	16
compared to those	16
in ml of	16
cytotoxic activity of	16
than the corresponding	16
lipophilicity of the	16
catalyst for the	16
their biological activities	16
using the same	16
appeared to be	16
with that of	16
the lipophilicity of	16
by column chromatography	16
suggesting that the	16
from the seeds	16
of phenolic mannich	16
activity comparable to	16
in the structure	16
of the selected	16
in vero cells	16
in vivo activity	16
effects of the	16
reference drug fluconazole	16
and evaluated their	16
and c nmr	16
the affinity of	16
a to k	16
to obtain a	16
to the synthesis	16
but also in	16
synthesis of compounds	16
c h n	16
and mg kg	16
active against the	16
supported by the	16
of action and	16
nmr spectra of	16
were based on	16
the central nervous	16
resulted to be	16
the prepared compounds	16
for antiviral activity	16
the combination of	16
relative to the	16
is essential for	16
in the field	16
novel mannich bases	16
an attempt to	16
cells infected with	16
the highest activity	16
to give a	16
shows that the	16
of the receptor	16
of mannich base	16
of all studied	16
the cell cycle	16
bioactive compounds and	16
series of new	16
declare no conflict	16
in vitro against	16
leads to the	16
mic values of	16
as a potent	16
docking studies of	16
hrv c pro	16
have been developed	16
can be found	16
the cell membrane	16
are responsible for	16
starting point for	16
compound was prepared	16
observed that the	16
were evaluated against	16
can be considered	16
it was also	16
cov and sars	16
the regulation of	16
was based on	16
from the marine	16
the selection of	16
in response to	16
hairy root cultures	16
were synthesized by	16
characterized by the	16
activity was evaluated	16
the mechanisms of	16
of the peptide	16
found to inhibit	16
belonging to the	16
the metabolism of	16
for this reason	16
the united states	16
demonstrated that the	16
required for the	16
have already been	16
contribute to the	16
the accumulation of	16
for the activity	16
activity against hiv	16
reported to be	16
the relationship between	16
were incubated at	16
as reference drug	16
inhibitor of the	16
the aminomethyl function	16
the coumarin nucleus	16
introduction of a	16
of the phenyl	16
compounds that are	16
compounds from the	15
fold more potent	15
root mean square	15
compounds may be	15
values between and	15
have been evaluated	15
more active against	15
of this enzyme	15
of the cells	15
small molecule inhibitors	15
in the s	15
of compound was	15
was found in	15
the possibility to	15
are given in	15
produced by the	15
as a new	15
cells with ic	15
then reacted with	15
was performed in	15
of a compound	15
in a concentration	15
investigation of the	15
in vitro antiviral	15
of in vitro	15
better than the	15
was more potent	15
means that the	15
the coumarin ring	15
antiviral activity and	15
be noted that	15
alanine and then	15
in a mouse	15
tested in vitro	15
most potent compounds	15
for in vitro	15
growth inhibition of	15
from the literature	15
the binding affinity	15
of bglu activity	15
of the mechanism	15
in relation to	15
groups on the	15
these compounds was	15
the c position	15
substituent at position	15
such as a	15
the host plant	15
was expressed as	15
the survival of	15
with an ec	15
the aim of	15
were screened for	15
of the plant	15
cytotoxicity of these	15
mic values between	15
are important for	15
the last decade	15
on the synthesis	15
proven to be	15
dried over anhydrous	15
after treatment with	15
assay was performed	15
isolated from a	15
the in vivo	15
the research team	15
were active against	15
was observed that	15
interact with the	15
design of new	15
is known to	15
after h of	15
moderate activity against	15
were selected for	15
proliferative activity against	15
the potential of	15
to interact with	15
the inhibitory effect	15
length of the	15
which was transformed	15
insight into the	15
the form of	15
the rest of	15
activity of new	15
of inhibition of	15
by the presence	15
was evaluated in	15
all the tested	15
also in the	15
were identified as	15
substituents on the	15
compounds were added	15
are found to	15
most potent compound	15
mechanism of the	15
the results revealed	15
its ability to	15
molecule inhibitors of	15
of compounds and	15
cells were seeded	15
the substitution of	15
the amount of	15
significant reduction in	15
of these mannich	15
psoralea corylifolia l	15
the degree of	15
more than one	15
of the reference	15
have the potential	15
added to each	15
reaction of the	15
presence of pybop	15
yellow fever virus	15
which is the	15
a reduction in	15
derivatives synthesis of	14
efficacy of the	14
are reported to	14
is an important	14
yang et al	14
as anticancer agents	14
there are no	14
comparison with the	14
cov m pro	14
vesicular stomatitis virus	14
the performance of	14
cells were fixed	14
antibacterial and antifungal	14
and the reaction	14
be due to	14
active site residues	14
and cytotoxicity of	14
inhibition zones of	14
hydrogen bonds with	14
the present work	14
bases of isatin	14
h n o	14
of a drug	14
an inhibitor of	14
on the activity	14
the endophytic fungus	14
with a high	14
compound was the	14
in this review	14
the toxicity of	14
is related to	14
volatile organic compounds	14
affinity for the	14
to identify the	14
of aminopeptidase n	14
antibacterial and antiviral	14
and it was	14
the mentioned compounds	14
to act as	14
of the substituent	14
activity against hepg	14
results indicate that	14
natural and synthetic	14
it is important	14
a yield of	14
the highest concentration	14
tested compounds showed	14
synthesis of the	14
assays were performed	14
new derivatives of	14
were performed using	14
of new n	14
the reason for	14
drugs for the	14
were more active	14
it could be	14
been used to	14
of this group	14
is important for	14
have been tested	14
reduction of the	14
only a few	14
the same year	14
compounds that have	14
have been widely	14
anhydrous na so	14
different types of	14
all compounds were	14
and identification of	14
anand et al	14
conducive to the	14
h n virus	14
activity against influenza	14
development of novel	14
a broad range	14
synthesis and anticonvulsant	14
not show any	14
p r e	14
is believed to	14
a new series	14
as a catalyst	14
comparison of the	14
p r o	14
also known as	14
the protein data	14
compared to other	14
leading to the	14
with different concentrations	14
molecular docking study	14
only in the	14
after oral administration	14
for min at	14
those of the	14
increasing concentrations of	14
to a solution	14
be conducive to	14
fact that the	14
reagents in the	14
of the complex	14
the compounds are	14
the levels of	14
more than of	14
action of these	14
to the corresponding	14
characterization of the	14
over anhydrous na	14
component of the	14
cell viability assay	14
the host cell	14
binding of the	14
can also be	14
for development of	14
broad range of	14
summarized in table	14
owing to the	14
the stability of	14
inhibitory effect of	14
in the plant	14
the prediction of	14
reported in the	14
the antioxidant activity	14
is associated with	14
equipotent to reference	14
known as the	14
and have been	14
is a major	14
the hydroxyl group	14
shown in fig	14
action of the	14
donno et al	14
several mannich bases	14
of the world	14
parts of the	14
of the phenolic	14
of the lmqc	14
for their antiviral	14
as a novel	14
was determined using	14
defined as the	14
were less potent	14
the induction of	14
excellent in vitro	14
their in vitro	14
potent activity against	14
to the cells	14
with mic values	14
the fruits of	14
was transformed to	14
of them were	14
the potential for	14
in the host	14
residues in the	14
substitution on the	14
presented in table	13
was equipotent to	13
mannich base derived	13
was possible to	13
and has been	13
series of coumarin	13
u r n	13
for in vivo	13
of a number	13
with the corresponding	13
base derived from	13
not only in	13
the aminomethyl group	13
antiviral effect of	13
the course of	13
reference drug diclofenac	13
of the side	13
the enzyme active	13
o u r	13
process for the	13
in most cases	13
of the total	13
was detected in	13
the first step	13
the sum of	13
should be noted	13
the virology branch	13
that the compounds	13
a l p	13
and mannich bases	13
hydrogen bonding with	13
and antibacterial activities	13
treatment of the	13
studies were performed	13
showed activity against	13
in the previous	13
is responsible for	13
of compound in	13
future science group	13
in this section	13
was concluded that	13
virtual screening and	13
of the inhibitors	13
were tested in	13
the target of	13
derivatives as potent	13
and the presence	13
high levels of	13
role of the	13
the compounds showed	13
the mixture of	13
against influenza virus	13
of the aromatic	13
was extracted with	13
j o u	13
to the method	13
which could be	13
for inhibition of	13
are present in	13
it was concluded	13
study showed that	13
the product was	13
of cytochrome c	13
for the inhibition	13
the results are	13
interacting with the	13
inhibitory activity and	13
derivatives have been	13
generally more potent	13
be attributed to	13
r n a	13
it was possible	13
these compounds had	13
rest of the	13
concentration of mm	13
coordinates of the	13
the rate of	13
r o o	13
the target compounds	13
an ec of	13
c and c	13
antibacterial activity was	13
l p r	13
then subjected to	13
suggest that the	13
need to be	13
reduction in the	13
in drug discovery	13
moiety in the	13
reported to have	13
play an important	13
was synthesized by	13
plant pathogenic fungi	13
showed the best	13
in the form	13
activity relationships of	13
end of the	13
synthesis and pharmacological	13
as reference compounds	13
oxygen atom of	13
was obtained by	13
o o f	13
the s pocket	13
antiviral effects of	13
in mes test	13
this means that	13
the isolation of	13
groups in the	13
most promising compounds	13
from the virology	13
to bind to	13
described the synthesis	13
comparable to those	13
as determined by	13
serial dilutions of	13
a library of	13
was added and	13
novel inhibitors of	13
to enhance the	13
the compounds in	13
showed that compounds	13
followed by the	13
by increasing the	13
activity relationship studies	13
are capable of	13
were incubated for	13
was stirred for	13
in vitro studies	13
attached to the	13
their biological activity	13
activation of the	13
enzyme active site	13
resistant strains of	13
reference drug indomethacin	13
of each compound	13
the field of	13
been studied in	13
and the mixture	13
was performed on	13
reference drug ciprofloxacin	13
the activities of	13
the mannich bases	13
small number of	13
biologically active compounds	13
logarithm of the	13
the determination of	13
the molecular docking	13
to provide a	13
these derivatives were	13
was confirmed by	13
of the three	13
g g phase	13
group in the	13
n a l	13
inhibit the growth	13
ring and the	13
the effectiveness of	13
the removal of	13
been used as	13
development of resistance	13
the prevention of	13
in the united	13
c pro inhibitors	13
three independent experiments	13
has led to	13
screening of a	13
by reaction with	13
cells were infected	13
interaction of the	13
the current study	13
biological activity and	13
in the cell	13
plaque reduction assay	13
compounds b and	13
determined by the	13
a mouse model	13
effects of these	13
we have previously	12
were detected by	12
compound and its	12
is shown in	12
in a single	12
in this respect	12
and the resulting	12
produced less active	12
three of them	12
in complex with	12
were recorded on	12
activity has been	12
the accuracy of	12
a value of	12
is necessary to	12
discovery and development	12
ccr and cxcr	12
and lmqc structures	12
the generation of	12
for viral replication	12
in the supplementary	12
has been a	12
drug discovery and	12
virus in vitro	12
selected compounds were	12
essential for the	12
compounds of series	12
one of them	12
of hydrogen bond	12
values for the	12
and there is	12
reported a series	12
against botrytis cinerea	12
the binding free	12
be associated with	12
acids and their	12
medicinal chemistry and	12
virtual screening of	12
radical scavenging activity	12
than those of	12
breast cancer cell	12
at mg ml	12
the obtained results	12
new compounds were	12
of virtual screening	12
is important to	12
in the region	12
are summarized in	12
can interact with	12
k i values	12
treated with compound	12
was obtained from	12
the emergence of	12
discovery of novel	12
disease caused by	12
majority of the	12
the roots of	12
most of them	12
on the contrary	12
the antimicrobial activity	12
differences in the	12
by reaction of	12
but they were	12
been used for	12
by contract no	12
advances in the	12
in silico studies	12
were used in	12
of new drugs	12
target for the	12
obtained at a	12
may be useful	12
treatment with compound	12
result of the	12
time of addition	12
their activity against	12
the cell lines	12
not only the	12
be explained by	12
and b viruses	12
the surface of	12
of new derivatives	12
derivatives of the	12
is used for	12
of severe acute	12
its mechanism of	12
of ketonic mannich	12
clinical trials for	12
the interaction with	12
for h and	12
a methyl group	12
target and the	12
in the production	12
influence of the	12
evaluation of mannich	12
the partition coefficient	12
has been found	12
were evaluated as	12
from the same	12
were prepared in	12
fold less potent	12
inhibitory effects on	12
be active against	12
can be seen	12
direct fl uorination	12
methods for the	12
inhibitory effects of	12
a or b	12
over the past	12
active against a	12
basis of the	12
the order of	12
schiff bases of	12
of these inhibitors	12
reported the synthesis	12
was supported by	12
for the discovery	12
is achieved by	12
their antifungal activity	12
tumour cell lines	12
taking into account	12
the pivot molecule	12
an attractive target	12
activity of this	12
recent advances in	12
in hepg cells	12
more effective than	12
cells were then	12
at a yield	12
most of these	12
been synthesized and	12
these results are	12
proposed the synthesis	12
of the chemical	12
to form the	12
in a cell	12
synthesized and tested	12
novel class of	12
with the enzyme	12
oral administration of	12
against influenza a	12
agreement with the	12
of the molecular	12
among the tested	12
in a recent	12
than the parent	12
the phenolic hydroxyl	12
ranging from to	12
from the fruits	12
and their biological	12
of inhibitors of	12
been carried out	12
could be a	12
methyl group at	12
probably because of	12
in view of	12
of new antibiotics	12
under reduced pressure	12
in the design	12
newly synthesized compounds	12
the last years	12
antiproliferative activity of	12
are widely used	12
influenza virus a	12
as potent as	12
not able to	12
cell lines and	12
obtained was as	12
liu et al	12
diseases such as	12
for some of	12
when compared with	12
the catalytic site	12
there are several	12
expressed as the	12
more cytotoxic than	12
of the anti	12
of the first	12
yield reduction assays	12
as described above	12
rat paw edema	12
h nmr spectra	12
act as a	12
and molecular modeling	12
were in the	12
the dipole moment	12
development of the	12
the oxygen atom	12
of small molecules	12
for their antifungal	12
showed ic values	12
with the virus	12
washed with water	12
been developed for	12
were obtained by	12
been isolated from	12
given in table	12
with activity against	12
of the genus	12
compared to compound	12
has been demonstrated	12
there has been	12
that the introduction	12
especially in the	12
influenza a and	12
was superior to	12
activity synthesis and	12
antiviral activities of	12
showed that these	12
against candida albicans	12
against both gram	12
broad spectrum antiviral	12
c and d	12
growth of the	12
it is necessary	12
of the novel	12
purified by column	12
model of the	12
contained in the	12
the ic value	12
of apoptotic cells	12
was stirred at	12
inhibition of virus	12
in the order	11
modes of action	11
loss of activity	11
was achieved by	11
believed to be	11
moiety at position	11
characterization of a	11
reference drug ampicillin	11
and for the	11
the compound is	11
antiprotozoal activity of	11
at the level	11
reverse transcriptase inhibitors	11
belong to the	11
a virtual screening	11
at the position	11
mannich base derivatives	11
the alkyl chain	11
the target products	11
correlated with the	11
cells were incubated	11
are active against	11
of novel mannich	11
in the activity	11
and antitumor activity	11
it is likely	11
mice infected with	11
the management of	11
activity against both	11
by the use	11
was also tested	11
days of incubation	11
virus replication in	11
inhibitory activity on	11
scores for the	11
compounds could be	11
partition coefficient in	11
cell cycle arrest	11
and evaluated as	11
to be of	11
compounds were active	11
presented as mean	11
using mtt assay	11
assessment of the	11
calculated for the	11
at r position	11
potential inhibitors of	11
the benzoxazine ring	11
in the lungs	11
have been obtained	11
in tissue culture	11
this work was	11
as substrates and	11
coxsackie b virus	11
the leaves of	11
activity was found	11
activity against c	11
used as an	11
owing to their	11
to the virus	11
viral replication and	11
to understand the	11
the size of	11
resulting in a	11
of naturally occurring	11
limit of detection	11
plants of the	11
interfere with the	11
crystal structures of	11
in the current	11
for antibacterial activity	11
those derived from	11
balb c mice	11
of the parent	11
hiv activity of	11
the efficiency of	11
performance liquid chromatography	11
derivatives were synthesized	11
the antiproliferative activity	11
with the protein	11
have not been	11
to the control	11
inhibition of hiv	11
human rhinovirus c	11
activity was expressed	11
the highest binding	11
the hydrolysis of	11
to each well	11
the latter is	11
cpe inhibition assay	11
and does not	11
mean square deviation	11
consistent with the	11
and properties of	11
activity against human	11
the binding mode	11
the source of	11
and could be	11
have been studied	11
which the qsar	11
d and f	11
development of potent	11
a systematic review	11
which leads to	11
the nitrogen atom	11
compounds did not	11
that they are	11
compounds for the	11
focused on the	11
compounds were found	11
the most recent	11
model obtained was	11
of the model	11
ec value of	11
plant extracts and	11
compound was obtained	11
was performed by	11
activity was also	11
number of hydrogen	11
of the free	11
inhibition of bglu	11
antioxidant activity in	11
moderately active against	11
the parent compound	11
could be considered	11
from the plant	11
by the reaction	11
anticancer activities of	11
and treated with	11
is required for	11
studies of the	11
is a well	11
was identified as	11
to be effective	11
in the following	11
ii clinical trials	11
bases and their	11
by inhibiting the	11
percentage of cells	11
was defined as	11
an in vitro	11
activity of coumarin	11
are required for	11
carried out with	11
be favorable for	11
compounds based on	11
alkaloids have been	11
on the phenyl	11
and anticonvulsant activity	11
a hydroxyl group	11
and to the	11
of the final	11
was comparable to	11
in a number	11
compound did not	11
results suggested that	11
and as a	11
synthesis and antitumor	11
subjected to the	11
the ns b	11
at physiological ph	11
hydrophobic interactions with	11
in vitro assays	11
have been designed	11
presence of an	11
the newly synthesized	11
of the newly	11
the action of	11
were calculated by	11
of these derivatives	11
para position of	11
number of compounds	11
good activity against	11
in their structure	11
hydroxyl group at	11
from the protein	11
we decided to	11
good antibacterial activity	11
were expressed as	11
compounds was evaluated	11
subjected to a	11
data not shown	11
of the s	11
discovery of new	11
a compounding pharmacy	11
h at room	11
rhinovirus c protease	11
c protease inhibitors	11
their activity was	11
is likely that	11
of the dipole	11
against the tested	11
morbidity and mortality	11
treatment with a	11
showed the most	11
cells treated with	11
the same conditions	11
organic layer was	11
considered as outliers	11
of broccoli seedlings	11
weak to moderate	11
enzyme activity was	11
c nmr spectra	11
may contribute to	11
for the compounds	11
growth factor receptor	11
human coronavirus e	11
were lower than	11
will be discussed	11
of compounds against	11
as a solvent	11
and that the	11
cell line was	11
and antioxidant activity	11
focusing on the	11
bglu activity in	11
and analysis of	11
of chalcone analogues	11
and it has	11
general procedure for	11
h nmr spectrum	11
mg ml and	11
and coworkers prepared	11
fl uorination of	11
was added dropwise	11
model for the	11
into account the	11
of small molecule	11
was attributed to	11
of the amine	11
docking study of	11
phase ii clinical	11
in line with	11
and the other	11
the rhizomes of	11
we have recently	11
size of the	11
of incubation at	11
ic values between	11
docking studies were	11
activity against gram	11
of the partition	11
from a marine	11
their antibacterial activity	11
comfa and comsia	11
seeds of p	11
studies have shown	11
studies have been	11
to the n	11
traditional chinese medicine	11
these prepared compounds	11
inhibition zone of	11
d and e	11
basis for the	11
this compound is	11
well as a	11
human airway epithelial	11
the site of	10
the perspective of	10
carried out to	10
of some mannich	10
of action for	10
in each well	10
appear to be	10
r and r	10
cytotoxicity of the	10
conformations of the	10
among the compounds	10
and double mannich	10
of the sars	10
was also observed	10
methionine aminopeptidase type	10
and in a	10
effects of compounds	10
extracted with etoac	10
of compound and	10
been associated with	10
participate in the	10
the phenolic group	10
than in the	10
concentrations of compounds	10
the concept of	10
activity of broccoli	10
lys and arg	10
side chain and	10
greater than that	10
are in the	10
nuclear magnetic resonance	10
were seeded at	10
form of the	10
of at least	10
demonstrated that compound	10
thanks to a	10
competitive inhibitor of	10
and more potent	10
the ring nitrogen	10
the antiviral effect	10
understanding of the	10
is also a	10
of type i	10
of compounds that	10
inhibitory activity in	10
with those of	10
view of the	10
compounds were calculated	10
for the control	10
a source of	10
lower than the	10
activity against different	10
been reported in	10
to the production	10
number of studies	10
of series i	10
with regard to	10
increase of the	10
did not affect	10
the free energy	10
the other compounds	10
site residues of	10
of cancer cell	10
these results indicate	10
biological evaluation and	10
prepared according to	10
treatment of covid	10
research and development	10
for drug discovery	10
lower than those	10
an ec value	10
on the inhibition	10
on the mechanism	10
plays an important	10
has been the	10
their antiviral activity	10
replication of the	10
of substituents on	10
and hydrogen bonding	10
by using the	10
antiviral activities against	10
potent inhibition of	10
on silica gel	10
it does not	10
was filtered off	10
and antioxidant activities	10
the residue was	10
selected for further	10
is found to	10
for the production	10
the screening of	10
to be safe	10
compound sweet gel	10
of alkaloids in	10
and the origin	10
as a consequence	10
mannich bases was	10
influenza a viruses	10
growth inhibition activity	10
in the ranges	10
reported in this	10
are used in	10
deprotection of the	10
against aspergillus spp	10
virus activity of	10
an animal model	10
the bioactivity scores	10
docking studies showed	10
results were obtained	10
out of the	10
based on this	10
with the aim	10
the most relevant	10
member of the	10
against a variety	10
the distribution of	10
among these compounds	10
and antibacterial activity	10
the crude product	10
of the substituents	10
and anticancer activity	10
necessary for the	10
the carbonyl group	10
replication in the	10
in aqueous solution	10
two of the	10
fl uorinated diazines	10
of these studies	10
patients with severe	10
less active derivatives	10
of plasmodium falciparum	10
observed from eq	10
of the inhibitor	10
were designed and	10
human breast cancer	10
compounds and the	10
of the p	10
compounds showed significant	10
amino acid groups	10
review of the	10
as an outlier	10
amine reagent in	10
randomized clinical trial	10
number of alkaloids	10
upon treatment with	10
of coumarin nucleus	10
by using a	10
the ranges of	10
influence on the	10
derivatives based on	10
the design and	10
are considered as	10
as a promising	10
an ic of	10
to interfere with	10
compound was also	10
attractive target for	10
was associated with	10
dissolved in ml	10
to target the	10
and mechanism of	10
a hydrogen bond	10
as potent and	10
ability of these	10
study was conducted	10
the content of	10
synthesis and structure	10
inhibited the growth	10
we have shown	10
synthesis and characterization	10
than those with	10
substituents at the	10
academy of sciences	10
and evaluated against	10
most potent inhibitor	10
broad singlet at	10
also able to	10
substituents in the	10
higher activity than	10
the least potent	10
properties such as	10
design of novel	10
in triplicate and	10
the proliferation of	10
as described previously	10
found to exhibit	10
were more efficient	10
the novel compounds	10
for drug design	10
should be considered	10
calculation of the	10
been used in	10
of essential oils	10
highly significant linear	10
the compound concentration	10
will be presented	10
of compound causing	10
molecular docking analysis	10
the same compound	10
on the structure	10
influenza virus activity	10
all the synthesized	10
bioactive compounds from	10
in virtual screening	10
in a humidified	10
activity and the	10
primary and secondary	10
the chemical modification	10
atom at position	10
compounds were selected	10
applications in the	10
clinical trials in	10
employed in the	10
the enzyme inhibition	10
inhibitory activity towards	10
overview of the	10
the best compounds	10
compounds and are	10
the same authors	10
cells were exposed	10
and pharmacological evaluation	10
of the target	10
were considered as	10
causal agent of	10
on vero cells	10
activity as a	10
the possibility of	10
the significance of	10
of them are	10
they have been	10
as a target	10
is characterized by	10
the group of	10
attention on the	10
rich compound sweet	10
the selectivity index	10
in the formation	10
source of bioactive	10
exposed to the	10
description of the	10
then incubated at	10
effective in the	10
using srb assay	10
three mannich bases	10
data taken from	10
have been isolated	10
more active compounds	10
was prepared from	10
the compound with	10
the purpose of	10
no effect on	10
state of the	10
in an attempt	10
was calculated by	10
zone of inhibition	10
synthesis and cytotoxicity	10
activity and cytotoxicity	10
isolation and characterization	10
compounds of the	10
of phenolic compounds	10
mg kg and	10
substituents at c	10
rna and dna	10
of action is	10
in isatis tinctoria	10
ca ix and	10
the onset of	10
considered as an	10
for each compound	10
molecules in the	10
with antiviral activity	10
were dissolved in	10
modifications of the	10
group on the	10
was set to	10
the amine moiety	10
hcv rna replication	10
new mannich bases	10
to the fact	10
the hydrophobicity of	10
and anticancer activities	10
the problem of	10
portion of the	10
was tested in	10
relationship between the	10
in an animal	10
point for the	10
fluorescent probe for	10
spectrum of activity	10
and were prepared	10
fold increase in	10
as the major	10
chen et al	10
was isolated from	10
as low as	10
the aromatic rings	10
significant increase in	10
calcd for c	10
a family of	10
further development of	10
inhibition at mm	10
a starting point	10
mixture was diluted	10
to the high	10
as antimycobacterial agents	10
regulation of the	10
influenza b virus	10
be useful in	10
with compound j	10
punta toro virus	10
stirred for h	10
the most commonly	10
with the highest	10
obtained by the	10
a broad singlet	10
the calculation of	10
a derivative of	10
based on coumarin	10
amino group in	10
the compound has	10
and discovery of	10
were observed in	10
of reactive oxygen	10
the advantages of	10
the marine sponge	10
assisted synthesis of	10
and evaluated for	10
melting points were	10
of the structure	10
supported by contract	10
pyrrole mannich bases	10
of these enzymes	10
with the use	10
product was purified	10
potency of the	10
to be involved	10
group and the	10
different from that	10
activity against all	10
starting at dpi	10
of diethylene glycol	10
a novel class	10
in the mes	10
but also the	9
resulting in the	9
to be highly	9
bind to the	9
the target product	9
in the nanomolar	9
for the evaluation	9
be effective in	9
explained by the	9
are necessary to	9
results in the	9
expected to be	9
was obtained as	9
and compared to	9
the nanomolar range	9
related compounds are	9
compound of the	9
structural features of	9
has to be	9
of the appropriate	9
they may be	9
mannich reaction of	9
the point of	9
vitro evaluation of	9
in cancer cells	9
natural products and	9
synthetic methods for	9
groups at the	9
can be applied	9
trypanosomal activity of	9
in another study	9
at this position	9
focused their attention	9
binding pocket of	9
mycobacterium tuberculosis h	9
studied bioactive compounds	9
oxidative stress and	9
the active center	9
which reacted with	9
to the identification	9
and their potential	9
the peptide core	9
regions of the	9
for further studies	9
rather than the	9
compound has been	9
in vitro antifungal	9
of the h	9
indicate that the	9
were obtained using	9
novel synthesis of	9
synthesis and anticancer	9
the food industry	9
evaporated to dryness	9
activity of coumarins	9
cell lines was	9
approach to the	9
synthesis of coumarins	9
achieved by the	9
has been studied	9
the yield was	9
lamarckian genetic algorithm	9
to be an	9
at a density	9
or mg kg	9
collaborators investigated the	9
hydrogen bond with	9
use in the	9
is due to	9
proved that the	9
tested against the	9
in vivo efficacy	9
compounds to the	9
closely related compounds	9
temperature for h	9
mg kg of	9
the benzene ring	9
mic values were	9
aminophosphonic acids and	9
case of compound	9
an increase of	9
enzymes in the	9
the reaction between	9
transport by pfcrt	9
derivatives were tested	9
be a useful	9
prepared starting from	9
the tsh fraction	9
anticancer activity against	9
inhibitory activity was	9
the toxic effects	9
a novel compound	9
were obtained as	9
for the selective	9
the positive control	9
human lung adenocarcinoma	9
expression of the	9
were compared with	9
the resulting mixture	9
active in vitro	9
ache and buche	9
widely used in	9
compounds showed a	9
useful in the	9
on the aromatic	9
can lead to	9
in spite of	9
purified by crystallization	9
was observed from	9
the anticonvulsant activity	9
calculated using the	9
vero e cells	9
k and a	9
between and mg	9
for the c	9
compounds was tested	9
each of these	9
day for days	9
a comprehensive review	9
mm compared to	9
plaque reduction assays	9
for further investigation	9
are associated with	9
included in the	9
molecular dynamics simulations	9
gause institute of	9
and docking studies	9
diseases caused by	9
chloroquine transport by	9
immunodeficiency virus type	9
bases obtained from	9
cell proliferation and	9
a and e	9
revealed that compounds	9
out that the	9
of endophytic fungi	9
to a decrease	9
is an effective	9
these compounds to	9
b and b	9
workers proposed the	9
and two of	9
the indole moiety	9
positions and of	9
out to be	9
h or ch	9
the quality of	9
as a control	9
cell lines using	9
the amino acid	9
of a small	9
prepared by the	9
molecular modeling studies	9
studies of novel	9
a medicinal plant	9
may lead to	9
in the next	9
antiproliferative activity against	9
of escherichia coli	9
to form a	9
and hexamethylene amiloride	9
that could be	9
for antiviral drugs	9
were grown in	9
synthesis and antibacterial	9
have been successfully	9
of more than	9
of the effect	9