quadgram

This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

quadgram	frequency
in the presence of	168
for the treatment of	127
on the other hand	101
for the synthesis of	95
in the case of	84
mannich bases derived from	84
was found to be	77
in vitro and in	76
vitro and in vivo	70
and biological evaluation of	68
in the treatment of	66
the presence of a	61
severe acute respiratory syndrome	61
as well as the	57
in the range of	55
were found to be	54
synthesis and biological evaluation	54
the presence of the	53
a wide range of	49
at position of the	48
the mechanism of action	46
for the development of	46
activity of mannich bases	46
one of the most	44
of mannich bases of	43
at a concentration of	41
chromatography to give compound	40
and then purified by	40
to the general procedure	39
the active site of	39
according to the general	39
of a series of	39
comparable to that of	38
it was found that	37
the nature of the	36
the reaction mixture was	36
reverse phase flash chromatography	36
that of reference drug	36
by reverse phase flash	36
food and drug administration	35
that the presence of	35
purified by reverse phase	35
were more potent than	35
flash chromatography to give	34
to the formation of	34
phase flash chromatography to	34
is one of the	34
then purified by reverse	34
the general procedure a	34
on the basis of	34
mechanism of action of	34
synthesized a series of	33
synthesis and in vitro	33
as a result of	32
at a dose of	31
broccoli sprouts and microgreens	31
the antiviral activity of	31
for the preparation of	31
for the first time	30
of the compounds were	30
with the exception of	30
in the mannich reaction	30
a large number of	30
as compared to the	29
was treated with n	28
a new class of	28
to be the most	28
with ic values of	28
the results showed that	27
acute respiratory syndrome coronavirus	27
dose of mg kg	27
to that of reference	27
potent than reference drug	26
synthesis and evaluation of	26
series of mannich bases	26
was used as a	26
more potent than reference	26
the antibacterial activity of	26
in the synthesis of	25
a novel series of	25
design and synthesis of	24
lower than that of	24
ic values in the	24
the results indicated that	23
as shown in table	23
the most active compound	23
compound was treated with	23
a dose of mg	23
an ic value of	23
of the tested compounds	23
the development of new	22
no conflict of interest	22
at the same time	22
it was shown that	22
in the context of	22
for the design of	21
united states food and	21
the qsar model obtained	21
was the most potent	21
mode of action of	21
as shown in figure	21
states food and drug	21
as shown in scheme	21
the structure of the	21
with a view to	21
the antifungal activity of	21
than that of the	21
of the test compounds	20
have been shown to	20
in the absence of	20
a wide variety of	20
hepg cells and mcf	20
in the active site	20
the crystal structure of	20
were evaluated for their	20
the title compound was	20
against a panel of	20
to be able to	20
the mode of action	19
for the detection of	19
of the compounds was	19
higher than that of	19
the results of the	19
similar to that of	19
and evaluation of their	19
it is worth noting	19
in the development of	19
is worth noting that	19
against the ebola virus	19
herpes simplex virus type	19
was shown to be	19
x for peer review	19
for peer review of	19
was used as the	19
as shown by eq	18
found to be the	18
the authors declare no	18
and antimicrobial activity of	18
compared to that of	18
to the development of	18
silica gel column chromatography	18
as well as in	18
phenolic mannich bases of	18
by silica gel column	18
a potent inhibitor of	18
to the presence of	18
both in vitro and	18
with an ic value	18
in order to obtain	17
by means of the	17
as amine reagents in	17
these results suggest that	17
with the active site	17
the search for new	17
have been reported to	17
it was suggested that	17
in vitro activity against	17
was as shown by	17
mannich bases of type	17
of broccoli sprouts and	17
at room temperature for	17
middle east respiratory syndrome	17
in vivo and in	17
purified by silica gel	17
as a positive control	17
in the search for	17
to the discovery of	17
cov cl pro inhibitors	17
compared to reference drug	17
the importance of the	17
an important role in	17
human cancer cell lines	17
group at the c	16
to the active site	16
a series of novel	16
the activity of the	16
values in the range	16
as the most potent	16
emerged as the most	16
procedure for the synthesis	16
in the series of	16
the formation of the	16
with ic values in	16
against hepg cells and	16
authors declare no conflict	16
were the most active	16
group at position of	16
synthesis and biological activity	16
the central nervous system	16
more potent than the	16
the most active compounds	16
was carried out using	16
compounds a and b	16
cells were treated with	16
declare no conflict of	16
alanine and then purified	15
of these mannich bases	15
of phenolic mannich bases	15
it was observed that	15
activity of these compounds	15
the results revealed that	15
compared to the standard	15
of the most common	15
in the aromatic ring	15
the most potent compounds	15
able to inhibit the	15
the evaluation of the	15
the most potent compound	15
crystal structure of the	15
are known to be	15
range of biological activities	15
the presence of pybop	15
the position of the	15
the synthesized compounds were	15
was used for the	15
in the discovery of	15
the introduction of the	15
the development of a	15
by the presence of	14
the biological activity of	14
over anhydrous na so	14
a broad range of	14
amine reagents in the	14
of the new compounds	14
fold more potent than	14
reaction mixture was stirred	14
of the triazole ring	14
and biological activity of	14
a new series of	14
more active than the	14
is based on the	14
led to the formation	14
dried over anhydrous na	14
activity against hepg cells	14
nmr spectra were recorded	14
used in this study	14
the length of the	14
c h n o	14
wide range of biological	14
in the aminomethyl function	14
at the concentration of	14
was the most active	14
the fact that the	14
synthesis of compounds a	14
the protein data bank	14
in the form of	13
a l p r	13
r o o f	13
j o u r	13
in addition to the	13
active site of the	13
to the synthesis of	13
hrv c pro inhibitors	13
substituent at position of	13
can be used to	13
the ability to inhibit	13
of this class of	13
the use of the	13
according to the method	13
compound was the most	13
to the standard drug	13
and the presence of	13
the rest of the	13
o u r n	13
in the field of	13
and antimicrobial activities of	13
did not show any	13
in the present study	13
mannich base derived from	13
play an important role	13
of these compounds were	13
the effect of the	13
p r o o	13
was more potent than	13
it should be noted	13
from the virology branch	13
equipotent to reference drug	13
to a solution of	13
the enzyme active site	13
l p r e	13
have been found to	13
in the same year	13
vivo and in vitro	13
was found that the	13
the ability of the	13
r n a l	13
u r n a	13
of the active site	13
compared to the reference	13
it was concluded that	13
be conducive to the	13
the most promising compounds	13
n a l p	13
it was possible to	13
antibacterial activity of the	13
a decrease in the	13
was added to each	13
of a number of	13
for the inhibition of	13
of all studied compounds	13
at a yield of	12
was performed using the	12
are presented in table	12
at the c position	12
inhibit the growth of	12
region of the protein	12
and the mixture was	12
in a mouse model	12
reported a series of	12
that most of the	12
at the end of	12
were tested for their	12
to that of the	12
a broad spectrum of	12
activity comparable to that	12
which was transformed to	12
from the seeds of	12
was carried out by	12
the discovery of a	12
the synthesis of new	12
were synthesized and evaluated	12
of the synthesized compounds	12
purified by column chromatography	12
the majority of the	12
described the synthesis of	12
the lipophilicity of the	12
its mechanism of action	12
east respiratory syndrome coronavirus	12
with respect to the	12
has been shown to	12
proposed the synthesis of	12
and biological activities of	12
can be considered as	12
of isatis tinctoria l	12
due to the presence	12
of mannich bases derived	12
cells were infected with	12
should be noted that	12
the removal of the	12
drugs for the treatment	12
is involved in the	12
obtained at a yield	12
was added to the	12
were isolated from the	12
of the selected compounds	12
activity of the compounds	12
of severe acute respiratory	12
the synthesis of compounds	12
that the introduction of	12
small molecule inhibitors of	12
in the production of	12
title compound was prepared	12
of the mechanism of	12
the end of the	12
and antifungal activity of	11
reagents in the mannich	11
it is necessary to	11
the development of novel	11
the analysis of the	11
the presence of an	11
the stability of the	11
of the side chain	11
qsar model obtained was	11
process for the preparation	11
in a number of	11
cells with ic values	11
by the use of	11
concentrations of the test	11
of the mannich bases	11
of ketonic mannich bases	11
in the united states	11
with different concentrations of	11
of action of the	11
proliferative activity against hepg	11
of the dipole moment	11
human rhinovirus c protease	11
were used as reference	11
were the most potent	11
mixture was stirred for	11
incubated for h at	11
was found in the	11
as in the case	11
of the phenyl ring	11
have the potential to	11
was based on the	11
synthesis of coumarin derivatives	11
activity was expressed as	11
were added to the	11
used in the treatment	11
most of the compounds	11
in the design of	11
the synthesis of coumarin	11
antibacterial activity of mannich	11
of the indole ring	11
evaluation of mannich bases	11
on the synthesis of	11
at the level of	11
h at room temperature	11
of the partition coefficient	11
catalyst for the synthesis	11
are found to be	11
this class of compounds	11
which the qsar model	11
the introduction of a	11
was purified by silica	11
be considered as a	11
model obtained was as	11
the design of new	11
the percentage of cells	11
and antitumor activity of	11
the binding free energy	11
action of these compounds	11
that the activity of	11
virus yield reduction assays	11
comparable to those of	11
has been developed for	11
have been synthesized and	11
for which the qsar	11
be responsible for the	11
as well as a	11
synthesized compounds were evaluated	11
in the aminomethyl group	11
by the reaction of	11
to be active against	11
found to be more	10
mechanisms of action of	10
product was purified by	10
hydroxyl group at the	10
target and the origin	10
in the last decade	10
generally more potent than	10
the partition coefficient in	10
were generally more potent	10
greater than that of	10
rich compound sweet gel	10
the chemical modification of	10
are summarized in table	10
on the phenyl ring	10
in the formation of	10
the formation of a	10
antifungal activity of the	10
inhibited the growth of	10
plays an important role	10
can be used in	10
to the fact that	10
supported by contract no	10
and molecular docking studies	10
general procedure for the	10
was shown that the	10
was defined as the	10
some of these compounds	10
an ec value of	10
of the most potent	10
for the production of	10
calcd for c h	10
as potent and selective	10
be attributed to the	10
a series of compounds	10
synthesis and characterization of	10
is a potent inhibitor	10
starting point for the	10
concentration of compound causing	10
were carried out using	10
a series of mannich	10
in the ranges of	10
it is likely that	10
cells were exposed to	10
influenza a and b	10
as amine reagent in	10
position of the triazole	10
for the discovery of	10
these results indicate that	10
with the use of	10
root mean square deviation	10
a novel class of	10
in an attempt to	10
the synthesis of a	10
of compounds a and	10
the most potent inhibitor	10
spectra were recorded on	10
synthesis of some new	10
was found to have	10
compounds were also tested	10
logarithm of the partition	10
compounds were evaluated for	10
against a variety of	10
of the interaction between	10
moiety at position of	10
the inhibitory effect of	10
in the structure of	10
and double mannich bases	10
to the production of	10
and anticonvulsant activity of	10
biological evaluation of novel	10
used as a positive	10
and incubated for h	10
in medicinal chemistry and	10
their ability to inhibit	10
different concentrations of the	10
than that of reference	10
on the mechanism of	10
rhinovirus c protease inhibitors	10
oxygen atom of the	9
can be used for	9
against cancer cell lines	9
of the mannich reaction	9
important role in the	9
the cytotoxicity of these	9
the efficacy of the	9
the tested compounds showed	9
the oxygen atom of	9
of the cell cycle	9
produced less active derivatives	9
the most promising compound	9
the basis of the	9
phase ii clinical trials	9
institute of new antibiotics	9
of reactive oxygen species	9
it was observed from	9
found to be a	9
probably because of the	9
of the coumarin ring	9
and in vivo studies	9
of the aromatic ring	9
the h nmr spectrum	9
the reaction of compound	9
of new derivatives of	9
their attention on the	9
a starting point for	9
synthesis and antimicrobial activity	9
the ability of these	9
atom at position of	9
the metabolic pathway classes	9
gause institute of new	9
of novel mannich bases	9
the mechanisms of action	9
been shown to be	9
is known to be	9
results showed that the	9
mycobacterium tuberculosis h rv	9
percentage of cells in	9
in vitro evaluation of	9
the gause institute of	9
as well as to	9
against herpes simplex virus	9
for their ability to	9
to afford the corresponding	9
on the inhibition of	9
in this study was	9
and synthesis of novel	9
isoforms i and ii	9
phenolic mannich bases derived	9
a small number of	9
are shown in figure	9
been developed for the	9
were carried out in	9
the inhibitory activity of	9
have shown that the	9
in the nanomolar range	9
synthesized and evaluated against	9
when compared with the	9
marine natural products marine	9
it is worth mentioning	9
focused their attention on	9
conducive to the activity	9
based on the inhibition	9
of this study was	9
the interaction between the	9
an attractive target for	9
amine reagent in the	9
from the fruits of	9
the compounds were tested	9
human immunodeficiency virus type	9
the treatment of ad	9
and collaborators investigated the	9
showed the highest activity	9
activity as compared to	9
used as reference compounds	9
it is important to	9
concentration of the compound	9
taking into account the	9
was then reacted with	9
were carried out by	9
were more active than	9
all the synthesized compounds	9
mixture was diluted with	9
on the biological activity	9
to the reference drug	9
of the effect of	9
are important for the	9
compounds were found to	9
in comparison with the	9
derivatives synthesis and biological	9
nature of the amine	9
synthesis and anticonvulsant activity	9
direct fl uorination of	9
between and mg ml	9
the inhibition of the	9
the pivot molecule rofecoxib	9
to the identification of	9
the influence of the	9
the treatment of many	9
a and b viruses	9
chloroquine transport by pfcrt	9
to be involved in	9
of cells in the	9
and in vitro anti	9
the h nmr spectra	9
it is possible that	9
mannich bases of isatin	9
most potent compound in	9
for the evaluation of	9
a series of new	9
from the endophytic fungus	9
of action of these	9
the size of the	9
workers proposed the synthesis	9
the role of the	9
synthesis and antitumor activity	9
and a to k	8
by the addition of	8
binding site of the	8
the crude product was	8
in the side chain	8
activity of broccoli sprouts	8
for h at room	8
mechanism of action for	8
it has been shown	8
are shown in table	8
a concentration of mm	8
from the point of	8
and anhydrous k co	8
rna and dna viruses	8
experiments were carried out	8
to a decrease in	8
added to each well	8
in order to evaluate	8
synthesis and anticancer activity	8
the new compounds were	8
probes and aggregation inhibitors	8
the synthesis of the	8
in broccoli sprouts and	8
anticonvulsant activity of new	8
not show any activity	8
this work was supported	8
of the activity of	8
with a value of	8
homology modeling and sequence	8
isolation and characterization of	8
we have shown that	8
inflammatory activity of mannich	8
reported the synthesis of	8
at the position of	8
results indicated that the	8
fold less potent than	8
from the marine sponge	8
the growth of the	8
of the compounds in	8
the method described by	8
mean and standard deviation	8
the cytotoxic activity of	8
this series of compounds	8
reagent in the mannich	8
none of the tested	8
the development of resistance	8
as well as their	8
the antiviral effects of	8
the mannich reaction with	8
j med chem doi	8
presented as mean and	8
in the perspective of	8
the point of view	8
be detrimental to the	8
and pharmacological evaluation of	8
was detected in the	8
antibacterial and antiviral activities	8
days of incubation at	8
this study was to	8
docking studies showed that	8
the mannich reaction of	8
to be the best	8
the value of the	8
the mixture was stirred	8
docking simulations showed that	8
was prepared starting from	8
to inhibit the growth	8
qsar model obtained for	8
in an animal model	8
is believed to be	8
development of new drugs	8
of some mannich bases	8
products marine natural products	8
of the prepared compounds	8
as potent as reference	8
and proved to be	8
the antifungal potency of	8
was stirred for h	8
at a density of	8
in type diabetic patients	8
useful in the treatment	8
the st and nd	8
of a wide range	8
were shown to be	8
synthesis and pharmacological evaluation	8
institute for medical research	8
a result of the	8
an increase in the	8
are one of the	8
antiviral activity of the	8
all the compounds were	8
compound was subjected to	8
the ic values of	8
a broad singlet at	8
could be used as	8
the resulting mixture was	8
compounds in this series	8
all of the compounds	8
at the molecular level	8
the case of compound	8
the synthesis of silver	8
be the most active	8
the most potent in	8
para position of the	8
plaque number reduction assay	8
a to k and	8
were observed in the	8
a number of other	8
it is interesting to	8
and c nmr spectra	8
of the active compounds	8
the treatment of chronic	8
reduce the risk of	8
in the brains of	8
point of view of	8
to k and a	8
the organic phase was	8
from the protein data	8
modeling and sequence alignment	8
the discovery of new	8
and the results were	8
be able to inhibit	8
group of the aglycone	8
the prepared compounds were	8
with an ec value	8
human tumor cell lines	8
with ec values ranging	8
room temperature for h	8
in order to determine	8
and antiprotozoal activity of	8
of these compounds was	8
the antimicrobial activity of	8
been found to be	8
imaging probes and aggregation	8
the interaction of the	8
was the most promising	8
to the method described	8
was comparable to that	8
the activity of mannich	8
added to the cells	8
molecular docking studies of	8
have been used for	8
taken from the literature	8
with ic values ranging	8
minimum energy conformations of	8
compound was prepared starting	8
k and a to	8
eur j med chem	8
feline infectious peritonitis virus	8
in the last years	8
natural products marine natural	8
all studied bioactive compounds	8
and respiratory syncytial virus	8
as mean and standard	8
number of hydrogen bond	8
synthesis of a series	8
was observed from eq	8
as the most active	8
with mic values of	8
were considered as outliers	8
in vitro antibacterial activity	8
active site residues of	8
of cancer cell lines	8
of hepatitis c virus	8
viral plaque number reduction	8
amino group of the	8
method for the synthesis	8
against a number of	8
of psoralea corylifolia l	8
considered as an outlier	8
data taken from the	8
the hydrolysis of the	8
as potent inhibitors of	8
the series of compounds	8
in the same metabolic	8
mic values between and	8
series of coumarin derivatives	8
mannich bases of chalcone	7
it is possible to	7
at c in co	7
were based on coumarin	7
ic values ranging from	7
encouraging in the perspective	7
displayed even at concentration	7
the most potent candidates	7
after h of incubation	7
than reference drug ampicillin	7
complexes were based on	7
release of antimicrobial substances	7
a number of alkaloids	7
significative antibiofilm activity at	7
in the low micromolar	7
compounds were tested for	7
and secondary aliphatic amines	7
properties of the compounds	7
in a variety of	7
was determined using the	7
in the number of	7
compounds based on the	7
in agreement with the	7
reservoir for the prolonged	7
biological activity of the	7
excellent in vitro activity	7
the majority of these	7
the prolonged release of	7
with the aim of	7
as well as compound	7
complexes useful as antibacterial	7
endophytic fungi isolated from	7
for further development of	7
were recorded on a	7
of the compounds with	7
were then incubated at	7
at the para position	7
that can be used	7
we have previously reported	7
in vitro study of	7
for the control of	7
amines as amine reagents	7
nmr data for compound	7
according to the results	7
the mentioned compounds were	7
for the prolonged release	7
in a similar fashion	7
in the mes test	7
purification and characterization of	7
of reference drug indomethacin	7
of a novel series	7
of mannich bases as	7
evaluated by means of	7
of the pivot molecule	7
with serial dilutions of	7
have been carried out	7
molecular docking studies showed	7
attracted the attention of	7
of substituents on the	7
molecular formula c h	7
are encouraging in the	7
superior to that of	7
and its hydroxylated derivatives	7
antimicrobial activity of some	7
presence or absence of	7
compound in this series	7
to the number of	7
and selective inhibitors of	7
showed significative antibiofilm activity	7
turned out to be	7
discovery of a novel	7
diazines in medicinal chemistry	7
of bioactive compounds from	7
of diethylene glycol tethered	7
activity compared to the	7
was suggested that the	7
been synthesized and evaluated	7
the binding site of	7
and a decrease in	7
the therapeutic potential of	7
the antiviral activity was	7
site of the enzyme	7
antifungal activity against a	7
with an ic of	7
the treatment of various	7
evaluation of irreversible human	7
proved to be the	7
substitution pattern in the	7
rega institute for medical	7
by the action of	7
and antiviral activity of	7
be used as a	7
useful as antibacterial agents	7
biological evaluation of a	7
on the structure of	7
for the prevention of	7
reports some of the	7
be explained by the	7
to good antibacterial activity	7
compounds were tested against	7
found to be active	7
containing diazines in medicinal	7
antiviral activity against a	7
in vitro antifungal activity	7
the treatment of covid	7
the series of mannich	7
stage of viral replication	7
activity was displayed even	7
led to the identification	7
biological functions of compounds	7
with inhibition zones of	7
compound emerged as the	7
of these compounds is	7
these results are encouraging	7
the compounds were also	7
the presence of electron	7
it is noteworthy that	7
the antiviral activity against	7
inhibit chloroquine transport by	7
seeds of psoralea corylifolia	7
mixture was refluxed for	7
in the first stage	7
of the most important	7
in vivo evaluation of	7
stirred for h at	7
in vitro activity of	7
recent advances in the	7
alerts health care professionals	7
antibacterial agents in sol	7
in the current study	7
it is known that	7
and a number of	7
the hydrophobicity of the	7
for these compounds was	7
drug administration fda alerts	7
coumarin complexes useful as	7
methyl group at position	7
was evaluated in vitro	7
as one of the	7
on the surface of	7
compounds were evaluated against	7
less active than the	7
a series of coumarin	7
from the roots of	7
from the rhizomes of	7
of some new mannich	7
synthesized and evaluated for	7
the range of e	7
table reports some of	7
completion of the reaction	7
it has been reported	7
medicinal chemistry and agrochemistry	7
the chemical structures of	7
in the fight against	7
the synthesis of novel	7
h and c nmr	7
even at concentration of	7
compounds were calculated using	7
summarizing the biological activity	7
in comparison to the	7
mannich bases and their	7
antimicrobial activity was displayed	7
proved to be able	7
were obtained as tfa	7
compounds were screened for	7
that these compounds are	7
but also in the	7
results are encouraging in	7
the world health organization	7
has been reported to	7
the concentration of the	7
of compound a on	7
tested in vitro against	7
that a number of	7
moderate to good antibacterial	7
dilutions of the test	7
it was found to	7
evaluation of some new	7
and some of them	7
activity against the ebola	7
on the use of	7
this article can be	7
and can be used	7
the antioxidant activity of	7
showed the presence of	7
the molecular target and	7
obtained as tfa salts	7
the para position of	7
attention due to their	7
which suggests that the	7
assay was performed as	7
novel mannich bases of	7
the same metabolic pathways	7
all the tested compounds	7
showed the most potent	7
to be used as	7
in the region of	7
had moderate to good	7
was obtained at a	7
the low micromolar range	7
irreversible human rhinovirus c	7
cells were seeded at	7
in most of the	7
of the peptide core	7
be used in the	7
been shown to have	7
showed that these compounds	7
may be conducive to	7
human airway epithelial cells	7
and characterization of a	7
as far as the	7
added and the mixture	7
work was supported by	7
have been isolated from	7
of irreversible human rhinovirus	7
of a new class	7
as antibacterial agents in	7
were moderately active against	7
at the university of	7
was transformed to upon	7
the c position was	7
designed and synthesized a	7
the design and synthesis	7
diethylene glycol tethered isatin	7
molecular target and the	7
obtained was as shown	7
the resulting mannich bases	7
identification and characterization of	7
compounds for the treatment	7
described in the literature	7
developed a series of	7
fda alerts health care	7
and drug administration fda	7
the most potent anti	7
bulgarian academy of sciences	7
structural insight into the	7
the compounds was evaluated	7
the toxic effects of	7
the coumarins mentioned above	7
the compounds with the	7
of these compounds against	7
inhibitory activity of the	7
are responsible for the	7
more potent than those	7
that of the parent	7
increasing concentrations of compounds	7
library of mannich bases	7
of the coumarins mentioned	7
their mode of action	7
a methyl group at	7
as a reference drug	7
compound showed significative antibiofilm	7
test at mg kg	7
is considered to be	7
broad spectrum of action	7
complexes as biomedical coatings	7
in the metabolism of	7
values of affinity energy	7
compounds b and c	7
its hydroxylated derivatives in	7
effect of compound a	7
article can be found	7
h nmr spectra of	7
the presence of cu	7
compounds were evaluated in	7
of the amino group	7
and anticancer activities of	7
the mannich reaction were	7
potent and selective inhibitors	7
the perspective of using	7
can be found in	7
an important source of	7
in the gause institute	7
biological evaluation of irreversible	7
target for the development	7
was supported by the	7
mechanism of action is	7
bases of chalcone analogues	7
for the identification of	7
prolonged release of antimicrobial	7
activity of new n	7
the antiviral effect of	7
of mannich bases with	7
these complexes were based	7
most active compound showed	7
drug discovery and development	7
was displayed even at	7
used in the study	7
review is given on	7
studies have shown that	7
the presence of increasing	7
by column chromatography using	7
recent studies have shown	7
analysis of the compound	7
carboxylatosilver and its hydroxylated	7
active compound showed significative	7
some of the coumarins	7
a mouse model of	7
at room temperature and	7
activity of some new	7
of reference drug fluconazole	7
potent antiviral activity against	6
the most active in	6
the active site residues	6
described by mccoll et	6
the qsar model eq	6
cytotoxicity and antiviral activity	6
resulted more active than	6
national institutes of health	6
hydrolyzed to the corresponding	6
anhydride according to the	6
mm compared to the	6
the seeds of p	6
can be seen from	6
crystal structure of sars	6
of the creative commons	6
based fluorescent probe for	6
not only in the	6
worth mentioning that the	6
in order to create	6
and synthesized a series	6
gel column chromatography to	6
a significant increase in	6
as can be seen	6
by mccoll et al	6
the activity compared to	6
led to a significant	6
participate in the same	6
study carried out by	6
measurements of p antigen	6
supported in part by	6
isolated from psoralea corylifolia	6
has been used to	6
open access article distributed	6
were calculated for the	6
of using agcoumarin complexes	6
could be a promising	6
in relation to the	6
epidermal growth factor receptor	6
table s in supporting	6
to be effective against	6
results suggested that the	6
the biological functions of	6
at the active site	6
of the hydroxyl group	6
the synthesis of tetrazoles	6
combined organic layer was	6
the highest binding affinity	6
to be responsible for	6
of the chlorine atom	6
betulin obtained from birch	6
these compounds have a	6
most of the tested	6
were obtained from the	6
cells were fixed with	6
activity of the newly	6
binding of the ligand	6
distributed under the terms	6
was found to exhibit	6
the anticonvulsant activity of	6
of human immunodeficiency virus	6
conformations of the compounds	6
as a solvent control	6
have been used to	6
in g g phase	6
different from that of	6
detrimental to the activity	6
compound was shown to	6
treated with different concentrations	6
the aromatic ring of	6
a comparative study of	6
a variety of different	6
with an inhibition zone	6
all of these derivatives	6
when compared to the	6
are listed in table	6
treatment with compound a	6
of the compound in	6
an open access article	6
antiviral activity against the	6
the search for novel	6
of broccoli sprouts on	6
the synthesis of bis	6
as amine reagent were	6
activity of this compound	6
were found to inhibit	6
as inhibitors of the	6
starting point for further	6
and antioxidant activity of	6
b virus activity of	6
the production of the	6
the phenolic hydroxyl group	6
influenced by increasing the	6
organic layer was washed	6
the percentage of apoptotic	6
antiviral activity of a	6
play a role in	6
position was carried out	6
the free energy of	6
the produced substance was	6
are characterized by the	6
carried out by the	6
coworkers described the synthesis	6
of the interaction of	6
mode of action and	6
southern poland by extraction	6
extraction with dichloromethane was	6
this class of compound	6
the treatment of compound	6
compared to the parent	6
the most potent inhibitors	6
be due to the	6
and coworkers prepared a	6
even better than the	6
based on inhibition of	6
mannich bases have been	6
c nmr spectra were	6
to those of reference	6
that the nature of	6
anticonvulsant properties of new	6
article is an open	6
known to be the	6
an endophytic fungus in	6
mice treated with compound	6
the viral life cycle	6
with the presence of	6
compounds were shown to	6
a few mannich bases	6
dissolved in ml of	6
cytotoxic than reference drug	6
in order to achieve	6
amino acid side chains	6
the structures of the	6
this article is an	6
the binding affinity of	6
of a new generation	6
of these compounds to	6
derivatives as inhibitors of	6
of compounds were mixed	6
was observed in the	6
the viral plaque number	6
to be a potent	6
human breast cancer cells	6
mts cell viability assay	6
used in the synthesis	6
isolation and identification of	6
were in the ranges	6
and anticonvulsant properties of	6
and their antifungal activity	6
of the amine moiety	6
at position of chromone	6
aminophosphonic acids and their	6
coumarins were isolated from	6
the development of newer	6
most potent in this	6
was superior to that	6
the dipole moment along	6
synthesis of some novel	6
which was found to	6
synthesis and antimicrobial activities	6
for the study of	6
reaction of a with	6
oxygen radical absorbance capacity	6
institute for antiviral research	6
of these compounds are	6
inhibitory activities than emodin	6
the replacement of the	6
were selected for further	6
is related to the	6
in southern poland by	6
agcoumarin complexes as biomedical	6
the mechanism by which	6
inhibition zones of e	6
the interaction with the	6
genscreen ultra hiv ag	6
harvested in southern poland	6
were carried out on	6
the catalytic site of	6
compounds a and e	6
as a colorless oil	6
insight into the viral	6
grafted sulfonated carbon titania	6
as well as by	6
in the first step	6
the aim of this	6
has been reported that	6
of the novel compounds	6
activity of the compound	6
inhibit the replication of	6
were in the range	6
in the regulation of	6
are fundamental for the	6
than those with a	6
in human embryonic lung	6
to participate in the	6
acids a and b	6
compounds of series i	6
was carried out with	6
with an ec of	6
for the presence of	6
the creative commons attribution	6
used as the starting	6
into the viral c	6
led to the discovery	6
withdrawing power of the	6
the compounds were calculated	6
compounds were active against	6
mg per g of	6
compound of the series	6
from birch bark harvested	6
h n o s	6
compounds were subjected to	6
and conditions of the	6
breast cancer cell line	6
for in vivo imaging	6
compounds are shown in	6
the presence or absence	6
with dichloromethane was used	6
purified by crystallization from	6
activity against a panel	6
was purified by column	6
using agcoumarin complexes as	6
conditions of the creative	6
properties of substituents on	6
of acyclic nucleoside phosphonates	6
are given in table	6
activity towards ca ix	6
for a number of	6
under the terms and	6
a review is given	6
was dissolved in ml	6
the evaluation of antiproliferative	6
of the reference drug	6
was washed with water	6
poland by extraction with	6
as well as its	6
no significant effect on	6
the synthesis of derivatives	6
of norovirus cl protease	6
table and table s	6
bark harvested in southern	6
mannich bases obtained from	6
zones of e mm	6
showed the best profile	6
the terms and conditions	6
was stirred at room	6
synthesis and antiprotozoal activity	6
birch bark harvested in	6
chemical modification of the	6
institute of organic chemistry	6
ca ix and xii	6
concentrations of compounds were	6
values comparable to those	6
compared to the control	6
were subsequently added to	6
the substitution of the	6
is an open access	6
of these compounds have	6
with a k i	6
and in vitro evaluation	6
in vitro inhibition of	6
that the tested compounds	6
a catalytic amount of	6
panel of cancer cell	6
was purified by crystallization	6
derivatives were tested against	6
of antiviral activity of	6
acids and their derivatives	6
the calculation of the	6
the genscreen ultra hiv	6
then purified by silica	6
nature of the amino	6
of mm compared to	6
of the reaction was	6
of these derivatives were	6
compound and its derivatives	6
ec values ranging from	6
the results were expressed	6
of the newly synthesized	6
by crystallization from ethanol	6
from the leaves of	6
as well as for	6
potent as reference drug	6
by the fact that	6
method was developed for	6
and coworkers described the	6
c position was carried	6
results are presented in	6
workers focused their attention	6
by flash column chromatography	6
as potential anticancer agents	6
of a hydroxyl group	6
reaction of a hydroxyl	6
using the mmt assay	6
in the supplementary material	6
out using diethyl chlorophosphate	6
evaluated for their activity	6
the rhizomes of a	6
a review of the	6
a substituent at c	6
of compounds b and	6
potent inhibitors of the	6
the first time the	6
perspective of using agcoumarin	6
layer was washed with	6
a phosphorylation reaction of	6
the ic value of	6
was observed that the	6
all of the mannich	6
probably due to the	6
dichloromethane was used as	6
argon atmosphere for h	6
using the genscreen ultra	6
of rna and dna	6
been reported to be	6
for the obtainment of	6
administration fda alerts health	6
the activity of compounds	6
to be more active	6
results suggest that the	6
two orders of magnitude	6
stirred at room temperature	6
regression equations were calculated	6
for compounds of series	6
can be applied to	6
compounds were able to	6
the design of novel	6
and antibacterial activity of	6
group as a substituent	6
lewis acid grafted sulfonated	6
of the carboxyl group	6
using disc diffusion method	6
for antiviral activity against	6
results are summarized in	6
the cytotoxicity of the	6
for their activity against	6
has been used as	6
towards ca ix and	6
the ebola virus in	6
inhibition of influenza virus	6
cells for h at	6
to their ability to	6
after concentrating the extracts	6
on the development of	6
was added and the	6
the cytotoxic effects of	6
with the aid of	6
to interact with the	6
reducing rat paw edema	6
rmsd for atoms of	6
for most of the	6
subsequently added to the	6
percentage of apoptotic cells	6
of the ligand to	6
compounds were mixed with	6
in contrast to the	6
some new mannich bases	6
to a mixture of	6
it is observed that	6
was developed for the	6
in the h nmr	6
values between and mg	6
comparison with the control	6
the severe acute respiratory	6
the most promising derivatives	6
for c h n	6
reaction of compound with	6
zone of mm compared	6
of human african trypanosomiasis	6
compared with that of	6
those with substituents at	6
is found to be	6
and concentrated in vacuo	6
was performed in triplicate	6
these results suggested that	6
position of the phenyl	6
were designed and synthesized	6
were lower than those	6
as a reference compound	6
have been screened for	6
broad spectrum of biological	6
cells were grown in	6
compared to the untreated	6
agents for the treatment	6
column chromatography to give	6
after treatment with a	6
compound was then reacted	6
as a substituent at	6
for some of the	6
present in the plant	6
an inhibition zone of	6
with a limit of	6
developed for the synthesis	6
yields ranging from to	6
release of cytochrome c	6
and anticancer activity of	6
these prepared compounds were	6
antifungal activity against c	6
were exposed to the	6
were less potent than	6
as catalyst for the	6
acid grafted sulfonated carbon	6
cancer cell lines using	6
from three independent experiments	6
the mixtures were subsequently	6
are present in the	6
evaluated in vitro and	6
s in supporting information	6
mg kg per day	6
a hydroxyl group at	6
as the starting substrate	6
means of the mannich	6
risk of chronic diseases	6
the combined organic layer	6
diethoxyphosphorylbetulin was obtained at	6
was also detected in	6
none of the compounds	6
peripheral blood mononuclear cells	6
was washed with brine	6
has been studied in	6
resulted in the discovery	6
method described by mccoll	6
to each well and	6
the in vitro anti	6
was synthesized by the	6
the mixture was diluted	6
the top of the	6
the compounds were evaluated	6
phosphorylation reaction of a	6
the c nmr spectrum	6
with a wide range	6
a panel of cancer	6
that it is a	6
carried out using the	6
of a previous work	6
by extraction with dichloromethane	6
were prepared according to	6
spectrum of biological activities	6
for the formation of	6
of the development of	6
antibacterial and antifungal activity	6
produced substance was purified	6
compound was found to	6
the binding pocket of	6
inhibitory activity of compound	6
melting points were determined	6
increases the lipophilicity of	6
to the coumarin nucleus	6
resistance in plasmodium falciparum	6
terms and conditions of	6
the compounds were active	6
access article distributed under	6
to be in the	6
of this type of	6
according to published procedures	6
results were expressed as	6
from the fruit of	6
of these prepared compounds	6
mixtures were subsequently added	6
dimethylglutaric anhydride according to	6
and antiviral activity against	6
performed in triplicate and	6
according to the procedure	6
synthesized and evaluated as	6
positions and of the	6
of the efficiency of	6
is due to the	6
predicted metabolic pathway classes	6
the case of the	6
against hepatitis c virus	6
phase i clinical trials	6
carried out using diethyl	6
this means that the	6
of the most promising	6
the mechanism of the	6
is worth mentioning that	6
the introduction of an	6
article distributed under the	6
could be considered as	6
substance was purified by	6
see table s in	6
obtained from birch bark	6
with substituents at c	6
for comfa and comsia	6
a member of the	6
inhibition zone of mm	6
a limit of detection	6
field but also in	6
is the most common	6
the obtainment of new	6
especially in the case	5
the fret enzyme assay	5
it has been found	5
the effects of the	5
escherichia coli methionine aminopeptidase	5
in the tested concentration	5
h n and h	5
of the fi rst	5
hydrogen bonds with the	5
of varicella zoster virus	5
and the reaction was	5
synthesis and antimalarial activity	5
of these viral proteins	5
were obtained at a	5
partition coefficient in i	5
on a panel of	5
those of reference drug	5
wide range of pharmacological	5
of incubation at c	5
for the determination of	5
the method previously described	5
while the presence of	5
mannich bases of heterocyclic	5
power of the substituent	5
based on the use	5
under reduced pressure and	5
were incubated at c	5
two phenolic mannich bases	5
and their potential applications	5
sulfonated carbon titania composite	5
compounds as well as	5
in a recent work	5
dilutions of test compounds	5
of psoralea corylifolia linn	5
synthesis of several coumarin	5
score values of the	5
the life cycle of	5
synthesis and anticonvulsant properties	5
and their molecular docking	5
human umbilical vein endothelial	5
serial dilutions of test	5
of the compounds a	5
to give the corresponding	5
and antioxidant activities of	5
could be explained by	5
the highest concentration of	5
a certain degree of	5
weaker than that of	5
in the order of	5
we deemed interesting to	5
assessment of the synthesized	5
the stib mouse model	5
for evaluation of the	5
synthesis of these compounds	5
confirmed the efficacy of	5
activities of these compounds	5
to be a suitable	5
of action of this	5
the cells were treated	5
some of them were	5
such as staphylococcus aureus	5
similar mechanism of action	5
the antioxidant properties of	5
agents synthesis and biological	5
to reduce the risk	5
cytotoxicity assessment of the	5
in the present work	5
activity was evaluated in	5
the hypothesis that the	5
the highest concentration tested	5
of the isolated compound	5
and their biological activities	5
quaternary ammonium salt derivatives	5
of a new series	5
in order to demonstrate	5
of several coumarin derivatives	5
reduction assays were performed	5
in order to verify	5
activity in vitro and	5
in the identification of	5
crude product was purified	5
bvm were used as	5
of the compounds to	5
and was found to	5
it was determined that	5
revealed for the first	5
by a set of	5
of a set of	5
most promising compound was	5
state boards of pharmacy	5
more potent activity than	5
it has been estimated	5
and their effects on	5
properties of new n	5
and consisted of measurements	5
lmqc structures are considered	5
against a range of	5
concentration of ng ml	5
part of the molecule	5
effects of these compounds	5
is essential for the	5
and the mechanism of	5
performed using the mtt	5
derivatives was performed using	5
antigen made using the	5
were monitored by thin	5
and lung pathology in	5
the treatment of patients	5
was evaporated to dryness	5
in the near future	5
in the fret enzyme	5
that the antiviral activity	5
active site of bglu	5
their activity was evaluated	5
could bind to the	5
a final concentration of	5
and resulted to be	5
with tyr and phe	5
dried over na so	5
the tested compounds inhibit	5
better than that of	5
are considered to be	5
of compound causing cell	5
consisted of measurements of	5
be used to develop	5
in the selection of	5
the fi rst representative	5
synthesis and antibacterial activity	5
all the compounds showed	5
ketonic mannich bases of	5
were also found to	5
most of these compounds	5
c in co in	5
of bioactive natural products	5
of alkaloids have been	5
melting point apparatus and	5
is an urgent need	5
to be more potent	5
of the host plant	5
this compound was not	5
the regulation of the	5
inhibition of the enzyme	5
the treatment of the	5
was due to the	5
are potent inhibitors of	5
the bioactivity scores for	5
error presented as mean	5
in addition to this	5
was as potent as	5
generalized born surface area	5
a remarkable antiviral activity	5
the reaction of a	5
by the st and	5
compared to standard drug	5
reference drug indomethacin in	5
the structural modification of	5
the bioactivity score of	5
activity against all the	5
compared to the other	5
which means that the	5
were performed on a	5
cirrhosis and hepatocellular carcinoma	5
were used for the	5
is determined by two	5
and cytotoxicity studies of	5
is higher than that	5
and sequence alignment of	5
a potential inhibitor of	5
chlorine atom at position	5
are close to the	5
results showed that compounds	5
and antiviral activities of	5
the late s and	5
favorable to the activity	5
less cytotoxic than reference	5
washed and overlaid with	5
indicated that most of	5
and the teicoplanin aglycone	5
of the alkyl chain	5
showed the ability to	5
majority of mannich bases	5
more potent than mannich	5
were also tested on	5
of the mentioned compounds	5
a solution of the	5
emodin derivatives linked with	5
bioassay results are presented	5
at mg kg after	5
inhibitory effect on the	5
the research of new	5
the biological effects of	5
sert and d receptor	5
activity evaluation of some	5
a highly significant linear	5
umbilical vein endothelial cells	5
on the aromatic rings	5
of a library of	5
the limit of detection	5
the presence of hydrogen	5
and antibacterial activities of	5
were incubated for h	5
were seeded at a	5
for sert and d	5
a novel approach to	5
cells when compared to	5
antibacterial activity of these	5
used as the standard	5
they were found to	5
may be responsible for	5
pharmacological properties such as	5
study was conducted on	5
the origin of the	5
reached phase ii clinical	5
auf wirksamkeit gegen malaria	5
betulin and bvm were	5
basis for design of	5
cell lines using srb	5
compared to compounds and	5
treated with compound j	5
formula c h n	5
was identified as a	5
concentration corresponding to the	5
compound concentration required to	5
carried out on a	5
in addition to their	5
on the treatment of	5
the target of the	5
was performed using a	5
compounds were selected for	5
at the entrance of	5
synthesis of new derivatives	5
synuclein imaging probes and	5
the score values of	5
compounds and were prepared	5
cl pro and hrv	5
malaria parasite plasmodium falciparum	5
et o et nh	5
energy conformations of the	5
hq and its derivatives	5
search for antiviral drugs	5
presence of nabh cn	5
structural basis for the	5
a good source of	5
the van der waals	5
it has not been	5
found to be equipotent	5
evaluation of a novel	5
is blocked by a	5
may be favorable for	5
inhibitory activity against a	5
appeared as the most	5
presumably due to the	5
at an early stage	5
p antigen made using	5
viral proteases and their	5
than those derived from	5
at the enzyme active	5
one of the first	5
in the human body	5
against four common bacteria	5
the study indicated that	5
by a compounding pharmacy	5
of the central nervous	5
of in vitro and	5
in good agreement with	5
ability of these compounds	5
primary human airway epithelial	5
the treatment of sars	5
the treatment of some	5
which was subjected to	5
has been estimated that	5
under the control of	5
as far as we	5
compound did not show	5
on c position of	5
mannich bases having a	5
in co in air	5
comparable to reference drug	5
treated and untreated wells	5
have been reported in	5
the potential to be	5
source of bioactive compounds	5
of the test compound	5
a plaque reduction assay	5
to a lesser extent	5
the seeds of psoralea	5
be favorable to the	5
binding free energy calculations	5
compound causing cell death	5
we would like to	5
were fixed and stained	5
we have recently reported	5
the antiviral activity and	5
antifungal activity against aspergillus	5
worth noting that the	5
compounds was as shown	5
were equipotent to reference	5
potent than the parent	5
bases of isatin derivatives	5
performed in order to	5
was carried out for	5
were calculated for each	5
obtained for these compounds	5
of the phenolic group	5
and the product was	5
that the inhibition of	5
the number of cells	5
compounds which can be	5
is also worth mentioning	5
that all the compounds	5
in a similar manner	5
and collaborators synthesized a	5
as the compound concentration	5
could be used to	5
compounds that have been	5
it is difficult to	5
of p antigen made	5
dissolved in dry pyridine	5
one or more viruses	5
already mentioned in the	5
are in agreement with	5
a potential source of	5
the molecular formula c	5
group at r position	5
phase was washed with	5
to be used in	5
prepared starting from and	5
of the most active	5
will focus on the	5
to give mannich bases	5
room temperature for min	5
has the highest binding	5
are shown in the	5
the presence of other	5
in the fruits of	5
found to be inactive	5
their activity against hiv	5
in order to produce	5
was calculated as the	5
the synergic effects of	5
that of the starting	5
expressed as the mean	5
known to be associated	5
r s a synthesis	5
tuberculosis h rv strain	5
for the most active	5
as an efficient catalyst	5
a phytochemical study on	5
excellent antibacterial activity against	5
been used as a	5
of the presence of	5
query compound c q	5
the development of potent	5
in each well of	5
inhibition of aminopeptidases by	5
number of hydroxyl groups	5
like protease inhibitors chapter	5
a mm stock solution	5
feline corona and feline	5
effects of compound on	5
we found that the	5
were subjected to the	5
the antioxidant potential of	5
the anticancer activity of	5
hiv activity was expressed	5
mannich bases of allomaltol	5
is similar to that	5
the preparation of the	5
made using the genscreen	5
in the solid state	5
it was demonstrated that	5
inhibitors of the interaction	5
small cell lung cancer	5
was prepared by the	5
followed by reaction with	5
the discovery of novel	5
the synthesized derivatives was	5
considered to be a	5
as the number of	5
against influenza b virus	5
cells were fixed and	5
compounds of series ii	5
was compared to that	5
n and h n	5
with a range of	5
significant influence on the	5
was expressed as ic	5
cell viability was determined	5
were found to have	5
and molecular modeling studies	5
as compared to standard	5
yielded the target derivative	5
the reduction of the	5
carried out with the	5
synthesis and cytotoxicity studies	5
indicating that these compounds	5
the number and the	5
in the next step	5
towards the development of	5
were calculated using the	5
of commercially available drugs	5
to evaluate the efficacy	5
shows the superposition of	5
synthesized derivatives was performed	5
a high degree of	5
of the ion channel	5
of measurements of p	5
a method was developed	5
highly significant linear regression	5
the activity of reference	5
an inhibitory effect on	5
increasing value of the	5
the investigation of the	5
some of the most	5
reduced pressure and the	5
by means of uplc	5
cytochrome c from mitochondria	5
the ligand to the	5
was added followed by	5
of the effects of	5
to the molecular formula	5
it can be used	5
less potent than reference	5
the cells were exposed	5
may be associated with	5
in the control of	5
at least in part	5
have proven to be	5
on the side chain	5
mannich bases were more	5
compared to the starting	5
can be attributed to	5
inhibitors for the treatment	5
our results suggest that	5
compounds in the series	5
did not affect the	5
showed ic values of	5
a score value above	5
all the compounds exhibited	5
residue was purified by	5
in the phenyl ring	5
in the supplementary materials	5
the polarity of the	5
enzymes involved in the	5
the treatment of this	5
a small series of	5
apoptosis in hepg cells	5
can be used as	5
to be a more	5
are available online at	5
their mechanism of action	5
to the highest concentration	5
it was established that	5
mixture was stirred at	5
prepared compounds were screened	5
activity in vitro against	5
the majority of mannich	5
fraction and compounds and	5
the mic values for	5
of the protecting group	5
the indole ring is	5
the national cancer institute	5
was able to inhibit	5
of herpes simplex virus	5
reported in the literature	5
the target compounds a	5
has been demonstrated that	5
of novel inhibitors of	5
one or more of	5
has been found to	5
for the management of	5
the synthesis of hybrid	5
and molecular docking study	5
have been tested in	5
in spite of the	5
the total number of	5
mannich bases generated from	5
to reference drug fluconazole	5
has the potential to	5
of the fact that	5
essential for viral replication	5
to produce more active	5
against mycobacterium tuberculosis h	5
means that the presence	5
the sum of the	5
as described in the	5
stability of the ligand	5
the completion of the	5
of the carbonyl group	5
of cytochrome c from	5
leading to cell death	5
which were then incubated	5
antibacterial activity against gram	5
as a target for	5
of fl uorinated diazines	5
may contribute to the	5
in the percentage of	5
upon in vitro evaluation	5
at the nitrogen atom	5
activity of compounds against	5
the university of michigan	5
used to determine the	5
in triplicate and repeated	5
of compounds based on	5
resulted in the formation	5
calculated using molecular mechanics	5
reference drug fluconazole against	5
was found to contain	5
evaluated against hepg cells	5
as the alkyne compound	5
in order to develop	5
and lmqc structures are	5
assays were performed in	5
based on the treatment	5
had antibacterial activity comparable	5
of the synthesized derivatives	5
as a function of	5
in traditional chinese medicine	5
position of the coumarin	5
was equipotent to reference	5
hydroxyl group in was	5
tests were carried out	5
a multiplicity of infection	5
with the binding pocket	5
cells in the presence	5
in a series of	5
the newly synthesized compounds	5
has led to the	5
discovery and development of	5
results were compared with	5
the absence of the	5
as a source of	5
and bvm were used	5
value of the dipole	5
the presence of nabh	5
significance is determined by	5
in a murine model	5
hepatitis b virus activity	5
compounds with the lowest	5
the development of drugs	5
spectra were recorded in	5
and antimicrobial evaluation of	5
by means of a	5
different concentrations of samples	5
and its derivatives were	5
mannich bases synthesis and	5
been reported in the	5
an endophytic fungus of	5
organic phase was washed	5
in silico studies of	5
dna and rna viruses	5
corona and feline herpes	5
were performed using the	5
cells were incubated for	5
model obtained for these	5
in the process of	5
emodin quaternary ammonium salt	5
rest of the compounds	5
conjugation with glucuronic acid	5
and antimicrobial screening of	5
the test compounds was	5
stirred the reaction mixture	5
are involved in the	5
antiviral activity and cytotoxicity	5
breast cancer cell lines	5
first example of a	5
ochratoxin a and b	5
and hrv c pro	5
tested compounds showed significant	5
in combination with other	5
be the most potent	5
of the starting antibiotic	5
based cpe inhibition assay	5
reactions were monitored by	5
the antibacterial potency of	5
to a significant reduction	5
gel column chromatography using	5
were expressed as cc	5
of the antiviral activity	5
concentrated under reduced pressure	5
were synthesized and tested	5
is given on the	5
the most potent candidate	5
causing inhibition of replication	5
van der waals interactions	5
the treatment of inflammatory	5
data and error presented	5
activity against the tested	5
the organic layer was	5
of the series of	5
the bioassay results are	5
that the compound is	5
in vitro antiviral activity	5
antiviral activity against h	5
the enhanced production of	5
following are available online	5
effi cacy and safety	5
the carbonyl group in	5
was carried out to	5
and van der waals	5
the results were compared	5
compared to the traditional	5
synthesis of mannich bases	5
used for the treatment	5
triplicate and repeated in	5
the side chain of	5
in the lungs of	5
was also shown to	5
there is an urgent	5
the synthesis and antiviral	5
may be useful in	5
well as in the	5
and aggregation inhibitors mm	5
as a tool for	5
results obtained by the	5
times more potent than	5
lines using srb assay	5
did not result in	5
are reported in figure	5
for the enhanced production	5
at the p position	5
of the length of	5
the crystal structures of	5
and feline herpes viruses	5
better than the reference	5
the flexibility of the	5
in the food industry	5
shown in figure a	5
than that of doxorubicin	5
and recrystallized from ethanol	5
which are known to	5
different parts of the	5
mannich bases as inhibitors	5
the first step of	5
concentration of ic and	5
as compared with the	5
and severe acute respiratory	5
of compound in the	5
to give the desired	5
the same authors also	5
enzyme is involved in	5
compounds were added at	5
in the active center	5
have reported on the	5
activity with an ic	5
as a consequence of	5
to be associated with	5
bases as inhibitors of	5
is interesting to note	5
data are expressed as	5
and halistanol sulfate c	5
antifungal potency of coumarin	5
derivatives were more active	5
cov cl pro and	5
due to the fact	5
equations were calculated for	5
a cytotoxicity assessment of	5
for the construction of	5
in such a way	5
and in silico studies	5
half maximal inhibitory concentration	5
mg kg body weight	5
compound a for h	5
statistical significance is determined	5
as substituent at position	5
the synthesis of several	5
the case of compounds	5
of the studied compounds	5
in triplicate and the	5
but none of the	5
replication and lung pathology	5
the most active among	5
was carried out in	5
of bglu activity as	5
the activation of several	5
in the activity of	5
presence of increasing concentrations	5
pro and hrv c	5
serial dilutions of the	5
mixture was heated at	5
tsh fraction and compounds	5
to the pivot compound	5
based on the results	5
natural and synthetic coumarins	5
activity against multidrug resistant	5
title compound was obtained	5
via the mannich reaction	5
reported in this study	5
of the use of	5
more potent than cisplatin	5
h nmr spectrum of	5
the antimycobacterial activity of	5
in the late s	5
synthesis and biological activities	5
may be a useful	5
the following are available	5
which can be used	5
was not able to	5
were used as controls	5
in order to minimize	5
in the stib mouse	5
been designed and synthesized	5
tested for their inhibitory	5
the residue was purified	5
in respect to the	5
a k i value	5
be more active than	5
concentration required to reduce	5
evaluated in terms of	5
added to the solution	5
the starting antibiotic a	5
of the binding pocket	5
compared to those of	5
and the nature of	5
and the degree of	5
is likely to be	5
order predicted metabolic pathway	5
order to obtain a	5
exchanges with d o	5
potential in the treatment	5
to the method previously	5
interesting to note that	5
evaluation and molecular docking	5
and error presented as	5
against trypanosoma brucei rhodesiense	5
h nmr spectrum showed	5
structural modifications of the	5
group of the peptide	5
with ic value of	5
was made in triplicate	5
activity against influenza a	5
virus replication in the	5
compound causing inhibition of	5
schiff bases of isatin	5
at low micromolar concentrations	5
the activation of the	5
in vitro screening of	5
has been reported in	5
and then subjected to	5
of compound causing inhibition	5
cytotoxicity of these compounds	5
ratio of cytotoxic to	5
has been shown that	5
significant linear regression equations	5
mannich base derivatives of	5
at positions and of	5
in each of the	5
treatment of compound a	5
of compounds with a	5
tidwell rr et al	5
residue in the aminomethyl	5
with a score value	5
in order to assess	5
is shown in fig	5
to the design of	5
to the importance of	5
isoforms ix and xii	5
and their activity was	5
can contribute to the	5
is possible that the	5
the antiviral efficacy of	5
superior to reference drug	5
concentrations of these compounds	5
collaborators synthesized a series	5
on the indole ring	5
it was proposed that	5
after the treatment of	5
the fruits of manilkara	5
the synthesized compounds showed	5
the results of these	5
the amino group of	5
the relationship between the	5
activity respect to the	5
the replication of the	5
the most potent antiviral	5
and a broad singlet	5
of the cells was	5
increase in the percentage	5
in line with the	5
the enzyme inhibitory activity	5
of increasing concentrations of	5
the concentration of ic	5
of allergy and infectious	5
the amino group in	5
and related compounds are	5
a promising target for	5
to be equipotent to	5
and acts as a	5
the reaction was monitored	5
values of the compounds	5
fluoroquinolones as amine reagents	5
virus yield reduction assay	5
and virus yield reduction	5
of camphoric acid with	5
the indole ring and	5
than reference drug ciprofloxacin	5
is important for the	5
with one of the	5
the activity of a	5
because most of the	5
these compounds were also	5
were shown to have	5
electrostatic potential of the	5
lower than those of	5
for their in vitro	5
it has been demonstrated	5
of one of the	5
one metabolic pathway class	5
may be due to	5
fruits of manilkara zapota	5
state of the art	5
their inhibitory activity against	5
ppm assigned to the	5
a large group of	5
the tested concentration range	5
after days of incubation	5
phenolic mannich bases moiety	5
and the formation of	5
types a and b	5
national institute of allergy	5
be useful in the	5
and molecular dynamics simulations	5
corresponding to the highest	5
comparable with that of	5
compared to those with	5
evaluation of a series	5
of feline infectious peritonitis	5
compounds at the concentration	5
that the majority of	5
institute of allergy and	5
is characterized by a	5
group in was protected	5
of mannich bases c	5
biotechnological studies on i	5
of the candidates were	5
the surface of the	5
we will focus on	5
endophytic fungi associated with	5
the dopamine d receptor	5
a condensation reaction between	5
activity of a series	5
for a long time	4
and mechanism of action	4
of texas medical branch	4
as potential inhibitors of	4
in the brain and	4
compared to compound a	4
as a biomarker of	4
synthesis of novel benzothiazole	4
the presence of dcc	4
the protonated nitrogen of	4
were also tested in	4
facile method for the	4
or absence of the	4
most potent compounds in	4
on cells for h	4
a key role in	4
structures were calculated for	4
under the title of	4
broad spectrum of activity	4
activity against topoisomerase i	4
it should not be	4
order to demonstrate the	4
the antibacterial activity was	4
with the addition of	4
cells under hypoxic conditions	4
was carried out on	4
acid was also detected	4
reduction and virus yield	4
solution of cg ca	4
as the main responsible	4
more than of all	4
led to the development	4
the description of the	4
development of the compound	4
by increasing the electron	4
are necessary for the	4
results indicate that the	4
at para position of	4
considered moderately active and	4
the ir spectrum showed	4
derivatives of glycopeptide antibiotics	4
both characterized by a	4
inhibition of hemozoin formation	4
that treatment with compound	4
to different concentrations of	4
through a double mannich	4
on the oxygen atom	4
be seen from the	4
seeded at a density	4
against one or more	4
number of cells in	4
in order to support	4
and cytotoxicity of new	4
be safe in humans	4
under the trade name	4
compounds was tested against	4
to one or more	4
of the compound was	4
used to analyze the	4
was further confirmed by	4
derivatives in the fruits	4
alabama school of medicine	4
and the type of	4
due to the structural	4
inhibition of enzyme activity	4
of reference drug ciprofloxacin	4
the causal agent of	4
dcu was filtered off	4
compounds are responsible for	4
a second series of	4
quality and security act	4
in mice treated with	4
with activity against the	4