bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
mannich bases	842
antiviral activity	318
cell lines	281
mg ml	251
inhibitory activity	226
reference drug	215
antibacterial activity	208
mg kg	193
antifungal activity	183
ic values	168
biological activity	155
mannich base	152
active site	147
virtual screening	138
cell line	137
amino acid	136
influenza virus	135
natural products	133
cancer cell	131
coumarin derivatives	125
molecular docking	115
clinical trials	114
bioactive compounds	108
biological activities	108
cancer cells	103
broccoli sprouts	103
antimicrobial activity	102
biological evaluation	99
amino acids	98
active compounds	94
antioxidant activity	91
secondary metabolites	89
bases derived	89
side chain	89
drug discovery	82
crystal structure	82
docking studies	82
phenolic mannich	79
mannich reaction	78
metabolic pathway	78
room temperature	78
respiratory syndrome	78
synthesized compounds	77
mic values	76
breast cancer	75
binding site	73
protease inhibitors	72
tested compounds	72
compounds showed	71
amino group	71
binding affinity	70
doc id	70
psoralea corylifolia	70
cord uid	70
activity relationship	69
acute respiratory	68
derivatives synthesis	65
compound showed	64
severe acute	64
plasmodium falciparum	64
vero cells	64
viral replication	64
column chromatography	63
small molecule	62
kcal mol	62
test compounds	61
phenyl ring	61
hydrogen bond	61
bglu activity	61
cell culture	61
ec values	60
hepg cells	60
side effects	60
medicinal chemistry	60
molecular modeling	60
activity relationships	60
antiviral drugs	59
drug design	59
silica gel	58
free energy	57
less active	57
reaction mixture	56
general procedure	56
pathway classes	56
wide range	56
small molecules	55
cell cultures	55
aromatic ring	55
amine reagents	54
cytotoxic activity	54
antiviral agents	54
hydroxyl group	54
related compounds	54
carboxylic acid	53
selected compounds	53
anticancer activity	53
antiviral activities	52
ebola virus	52
mouse model	51
main protease	51
hydrogen bonding	51
new compounds	50
broad spectrum	50
ic value	50
herpes simplex	50
virus replication	50
endophytic fungus	50
inflammatory activity	49
simplex virus	49
biologically active	49
united states	48
animal models	47
potent inhibitors	47
binding pocket	47
oxidative stress	47
infected cells	47
cell viability	46
give compound	46
ns pro	46
methionine aminopeptidase	46
inhibitory effect	46
antitumor activity	45
qsar model	45
leucine aminopeptidase	45
growth inhibition	45
cell death	45
antiproliferative activity	45
phenolic compounds	44
nmr spectra	44
compounds exhibited	44
anticonvulsant activity	44
vitro activity	44
cell cycle	44
performed using	43
cl pro	43
anticancer agents	43
isatis tinctoria	43
hydrogen bonds	43
less potent	43
positive control	42
reverse transcriptase	42
medicinal plants	42
molecular dynamics	42
oral administration	42
flash chromatography	42
ketonic mannich	41
selectivity index	41
schiff bases	41
new class	41
phase ii	40
drug resistance	40
like protease	40
inhibitory effects	40
hela cells	40
antimicrobial activities	40
also showed	40
commercially available	39
different concentrations	39
syndrome coronavirus	39
reverse phase	39
cell proliferation	39
antimycobacterial activity	39
rna polymerase	38
fl uorouracil	38
amine reagent	38
results showed	38
two compounds	38
yellow solid	38
virus type	38
large number	38
potent anti	38
drug development	37
resistant strains	37
drug administration	37
vitro anti	37
widely used	37
van der	37
binding mode	37
aliphatic amines	37
organic compounds	36
active compound	36
bacterial strains	36
trypanosomal activity	36
standard drug	36
antiviral compounds	36
prepared compounds	36
nervous system	36
phase flash	36
endophytic fungi	36
binding free	36
double mannich	36
force field	36
reference compounds	35
escherichia coli	35
secondary aliphatic	35
higher activity	35
staphylococcus aureus	35
cov cl	35
inhibitory activities	35
antibacterial agents	35
pro inhibitors	34
cell growth	34
enzyme activity	34
syn aggregation	34
side chains	34
coumarin nucleus	34
ethyl acetate	34
human immunodeficiency	34
binding energy	34
positive bacteria	34
inhibitory potency	34
transition state	34
normal cells	33
phase i	33
inhibition activity	33
animal model	33
tissue culture	33
see scheme	33
essential oils	33
negative bacteria	33
vaccinia virus	33
calculated using	33
virus infection	33
also tested	32
studied compounds	32
acid derivatives	32
mass spectrometry	32
methyl group	32
newly synthesized	32
receptor binding	32
zoster virus	32
potent inhibitor	32
molecular weight	32
novel compounds	32
lead compound	31
dependent manner	31
central nervous	31
type i	31
first time	31
mtt assay	31
well plates	31
see table	31
previous studies	31
marine natural	31
compounds may	31
antiviral effect	31
pseudomonas aeruginosa	30
drug candidates	30
antiviral effects	30
immunodeficiency virus	30
results indicated	30
dipole moment	30
acetic acid	30
throughput screening	30
oral bioavailability	30
bacterial bglu	30
medicinal plant	30
based virtual	30
previously described	30
antioxidant properties	30
results suggest	30
inhibitory concentration	30
metal ions	30
low toxicity	29
new derivatives	29
virus growth	29
studies showed	29
pathogenic fungi	29
reduction assay	29
moderate activity	29
cell membrane	29
influenza viruses	29
growth factor	29
hydrophobic interactions	29
acid residues	29
hiv activity	29
chemical descriptors	29
life cycle	29
plant extracts	28
activity compared	28
cytopathic effect	28
botrytis cinerea	28
showed good	28
mycobacterium tuberculosis	28
infected mice	28
pharmacokinetic properties	28
high affinity	28
der waals	28
proliferative activity	28
good activity	28
host plant	28
highly active	28
clinical studies	28
antimicrobial agents	28
plaque reduction	28
syn oligomers	27
betulinic acid	27
values ranging	27
trypanosoma brucei	27
reduction assays	27
agents synthesis	27
clinical trial	27
novel coronavirus	27
important role	27
determined using	27
novel series	27
fusarium oxysporum	27
radical scavenging	27
antiviral drug	27
hydroxyl groups	27
docking study	27
tumor cell	27
activity towards	27
viral rna	27
antimalarial activity	27
moderately active	27
potent compounds	27
pdb id	27
therapeutic agents	27
naturally occurring	27
virus yield	27
quantitative structure	26
potential anti	26
triazole derivatives	26
scavenging activity	26
respiratory syncytial	26
nitrogen atom	26
human cancer	26
fl uoro	26
potent activity	26
lipid peroxidation	26
dependent rna	26
indole ring	26
dengue virus	26
inhibition assay	26
showed significant	26
fl uorinated	26
nucleic acid	25
virus activity	25
substitution pattern	25
human health	25
public health	25
endothelial cells	25
cpe inhibition	25
fever virus	25
triazole ring	25
broccoli sprout	25
inflammatory drugs	25
oxygen atom	25
infectious diseases	25
closely related	25
sars coronavirus	25
derivatives showed	25
natural compounds	25
enzyme inhibition	24
human lung	24
viral dna	24
ionic liquids	24
biological properties	24
cytokine storm	24
type diabetes	24
syncytial virus	24
results obtained	24
molecular target	24
highly selective	24
aqueous solution	24
chemical structures	24
chalcone analogues	24
viral infection	24
spectrum antiviral	24
surface area	24
ring system	24
cov clpro	24
fatty acids	24
chloroquine resistance	24
topoisomerase i	24
reference drugs	24
pathway class	24
new drugs	24
based compounds	24
metal ion	23
fluorescent probe	23
glucuronidase activity	23
chromatography using	23
bglu inhibitors	23
gene expression	23
partition coefficient	23
candida albicans	23
md simulation	23
evaluated using	23
chemical structure	23
prostate cancer	23
isolated compounds	23
rna viruses	23
rhizoctonia solani	23
enveloped viruses	23
high activity	23
streptomyces sp	23
kg day	23
data determined	23
glucuronidase inhibitors	23
vivo studies	23
high selectivity	23
antiviral properties	23
model obtained	23
spike protein	22
vitro evaluation	22
table iv	22
human breast	22
chemical modification	22
data bank	22
cl protease	22
least one	22
plant species	22
hexamethylene amiloride	22
monoclonal antibody	22
toxic effects	22
fi rst	22
adverse effects	22
plant growth	22
cell wall	22
reactive oxygen	22
three compounds	22
immune response	22
antibacterial activities	22
experimental data	22
tsh fraction	22
lead compounds	22
selective inhibitors	22
also used	22
recent years	22
authors declare	22
less toxic	22
human coronavirus	22
aromatic rings	22
supplementary materials	22
previously reported	22
showed high	22
worth noting	22
ng ml	22
activity evaluation	22
electrostatic potential	21
varicella zoster	21
obtained using	21
highly significant	21
host cell	21
syn fibrils	21
compounding errors	21
ion channel	21
inhibition zones	21
cytotoxic effects	21
converting enzyme	21
highly effective	21
hepatocellular carcinoma	21
mdck cells	21
states food	21
analgesic activity	21
signaling pathway	21
muscodor albus	21
significant reduction	21
structurally related	21
fold less	21
substituted phenyl	21
carboxylic acids	21
viral infections	21
nitro group	21
sar studies	21
aminophosphonic acids	21
selectivity towards	21
protein data	21
carbon atoms	21
pechmann condensation	20
approved drugs	20
molecular mechanics	20
ch cl	20
showed moderate	20
mes test	20
coumarin scaffold	20
may also	20
middle east	20
crystal structures	20
fluorescent probes	20
protein kinase	20
wide variety	20
compounding pharmacies	20
free conditions	20
reference compound	20
gel column	20
low micromolar	20
compounds containing	20
promising compounds	20
another study	20
world health	20
fl uorine	20
protein synthesis	20
cell types	20
metabolic pathways	20
title compound	20
aminomethyl function	20
several studies	20
present study	20
culture medium	20
defense compounds	20
halistanol sulfate	20
prenylated coumarins	20
activity synthesis	20
marine sponge	20
ns protease	20
potent compound	20
hairy root	20
peer review	20
activity comparable	20
structural features	20
site residues	20
rheumatoid arthritis	19
liquid chromatography	19
structural modification	19
endophytic actinomycetes	19
two different	19
compound also	19
hydrogen atoms	19
ic mm	19
enpp inhibitors	19
inhibitors synthesis	19
potential antiviral	19
compound exhibited	19
also found	19
health organization	19
carbonyl group	19
statistically significant	19
cells infected	19
para position	19
test compound	19
research team	19
new anti	19
camphoric acid	19
starting point	19
recent advances	19
commonly used	19
molecule inhibitors	19
also exhibited	19
novel mannich	19
target proteins	19
apoptotic cells	19
ec value	19
diffusion method	19
effective concentration	19
compounds isolated	19
imaging probes	19
epithelial cells	19
nucleoside phosphonates	19
coli bglu	19
synthesized using	19
oxygen species	19
pyrrole ring	19
ki values	19
nmr data	19
yield reduction	18
synuclein aggregation	18
antifungal agents	18
candida activity	18
series i	18
amine moiety	18
several compounds	18
chromone derivatives	18
sleeping sickness	18
interactive compounds	18
outsourcing facilities	18
based design	18
receptor antagonists	18
hiv infection	18
receptor antagonist	18
results revealed	18
east respiratory	18
rosette leaves	18
medium containing	18
experimental conditions	18
previous study	18
monoclonal antibodies	18
cell type	18
low cytotoxicity	18
chemical space	18
dihydrofolate reductase	18
micromolar range	18
free radicals	18
coumarin ring	18
nanomolar range	18
knoevenagel condensation	18
helicobacter pylori	18
drug repurposing	18
potent antiviral	18
hydroxyquinoline derivatives	18
microwave irradiation	18
also investigated	18
antiviral research	18
cytotoxic agents	18
syn aggregates	18
hcv rna	18
double bond	18
independent experiments	18
target compounds	18
functional foods	18
nmr spectrum	18
per well	18
novel inhibitors	18
plant pathogens	18
pharmacological activities	18
mm tris	18
alkyl chain	18
water solubility	18
mice treated	18
phytopathogenic fungi	18
recent studies	18
ferulic acid	18
pharmacological properties	18
catalytic site	17
also known	17
broccoli seedlings	17
minor groove	17
rna synthesis	17
immune stimuli	17
antifungal activities	17
teicoplanin aglycone	17
african trypanosomiasis	17
acyclic nucleoside	17
paw edema	17
significantly reduced	17
human embryonic	17
body weight	17
candidates derived	17
ch ch	17
antiviral efficacy	17
layer chromatography	17
yellow fever	17
aspergillus niger	17
water molecules	17
using various	17
kinase inhibitors	17
fatty acid	17
adrenergic receptor	17
viral proteins	17
natural product	17
therapeutic potential	17
traditional chinese	17
feline infectious	17
energy minimization	17
salicylic acid	17
new series	17
hiv agents	17
chemical compounds	17
based assays	17
inhibition zone	17
antimycobacterial agents	17
cytotoxic concentration	17
results indicate	17
compound may	17
nitric oxide	17
vivo activity	17
active derivatives	17
fungal cell	17
also observed	17
aromatic aldehydes	17
oh group	17
infectious peritonitis	17
exhibited significant	17
lung cancer	17
different types	17
showed activity	17
rna replication	17
pyrimidine derivatives	17
blood pressure	17
fungal pathogens	17
supporting information	17
compounding pharmacy	17
one derivatives	17
health care	17
protease inhibitor	17
root cultures	17
medicinal compounds	17
scoring functions	17
tumour cell	17
anticancer activities	17
sulfonic acid	16
anticoagulant activity	16
thymidine kinase	16
biological material	16
high throughput	16
molecular structure	16
halogen atom	16
broad singlet	16
carcinoma cell	16
per day	16
bismuth compounds	16
human airway	16
highest activity	16
described previously	16
inflammatory activities	16
synthetic methods	16
series ii	16
fungal strains	16
essential oil	16
brain barrier	16
drug fluconazole	16
using molecular	16
carboxamide derivatives	16
polar volume	16
sar study	16
chemokine receptor	16
potential inhibitors	16
chromone core	16
mean square	16
score values	16
protective effects	16
minimum energy	16
hemozoin formation	16
functional groups	16
colon cancer	16
serial dilutions	16
substituted compounds	16
virus infections	16
antioxidant activities	16
ccr cxcr	16
inflammatory cytokines	16
also shown	16
ascorbic acid	16
sweet gel	16
qsar models	16
volatile organic	16
dna viruses	16
ray diffraction	16
enzyme assay	16
tumor growth	16
virus diseases	16
supplementary material	16
derivatives containing	16
study showed	16
hiv replication	15
glucuronic acid	15
virus titers	15
compounds tested	15
treated animals	15
six compounds	15
phenolic hydroxyl	15
human body	15
different mechanisms	15
spectral data	15
target protein	15
glycopeptide antibiotics	15
cells ml	15
indigo precursors	15
dpph radical	15
square deviation	15
potent inhibition	15
vitro antiviral	15
carbonic anhydrase	15
first step	15
two new	15
nucleoside analog	15
pharmacological activity	15
methoxy group	15
widely distributed	15
compound concentration	15
good antibacterial	15
coronavirus disease	15
antitumour activity	15
biofilm formation	15
host plants	15
western blot	15
also evaluated	15
web server	15
antimalarial drug	15
biological functions	15
combination therapy	15
weight loss	15
antiinflammatory activity	15
hydrazine hydrate	15
host cells	15
studies synthesis	15
vesicular stomatitis	15
nitrogen atoms	15
arbuscular mycorrhizal	15
starting material	15
leaf spot	15
compounds using	15
root mean	15
novel anti	15
virology branch	15
last decade	15
synthetic derivatives	15
test set	15
research groups	15
human cells	15
brassica oleracea	15
using mtt	15
primary human	15
compounds bearing	15
virus entry	15
reduced pressure	15
isatin derivatives	15
potential anticancer	15
cells using	14
discovery studio	14
systematic review	14
nmr spectroscopy	14
lewy bodies	14
present work	14
broad range	14
autodock vina	14
living cells	14
prominent activity	14
several mannich	14
affinity energy	14
molecular design	14
showed higher	14
nucleoside analogues	14
brucei rhodesiense	14
new antibiotics	14
dna polymerase	14
chlorine atom	14
increasing concentrations	14
highest concentration	14
chloroquine transport	14
scoring function	14
jurkat cells	14
chemical defense	14
marine organisms	14
substituted coumarins	14
normal cell	14
containing compounds	14
mm nacl	14
cov infection	14
compounds displayed	14
diabetes mellitus	14
novel compound	14
assisted synthesis	14
san diego	14
interaction energy	14
mammalian cells	14
bvdv rdrp	14
target products	14
viability assay	14
organic chemistry	14
mycelial growth	14
bacillus subtilis	14
studies revealed	14
leukemia cells	14
spectrum showed	14
plant pathogenic	14
triazene derivatives	14
mentioned compounds	14
anhydrous na	14
whereas compound	14
negatively charged	14
fl uorination	14
neutral red	14
new drug	14
stomatitis virus	14
method using	14
another approach	14
parent compound	14
mm respectively	14
ros generation	14
chemical entities	14
high levels	14
relationship studies	14
cytotoxicity towards	14
cellular proteins	14
clinical development	14
physicochemical properties	14
inhibitory potential	14
bglu inhibition	14
conformational analysis	14
md simulations	14
cytostatic activity	14
therapeutic efficacy	14
treated cells	14
workers proposed	14
bond interactions	14
docking simulations	14
coumarin complexes	14
enzyme active	14
conformational changes	14
worth mentioning	14
emodin derivatives	14
ii clinical	14
lung adenocarcinoma	14
promising compound	14
two candidates	14
antitubercular activity	14
chemotherapeutic agents	14
phenolic acids	14
metal complexes	13
chemical composition	13
days post	13
inflammatory agents	13
pivot molecule	13
promising anti	13
small number	13
docking analysis	13
human intestinal	13
group displayed	13
mass spectra	13
srb assay	13
hydrazone derivatives	13
future science	13
rich compound	13
new coumarin	13
three independent	13
periodontal disease	13
best compounds	13
also reported	13
chinese medicine	13
new mannich	13
significant linear	13
carboxyl group	13
better activity	13
aggregation inhibitors	13
treated mice	13
pc cells	13
base derived	13
antiviral therapy	13
extracts showed	13
years ago	13
orally bioavailable	13
added dropwise	13
indole derivatives	13
drug indomethacin	13
higher affinity	13
final concentration	13
silico studies	13
alkyl chains	13
estrogen receptor	13
compounded medications	13
antioxidant capacity	13
competitive inhibitor	13
structure activity	13
minimum inhibitory	13
tumor cells	13
towards human	13
showed prominent	13
dna synthesis	13
standard deviation	13
current study	13
rat paw	13
immune system	13
hybrid molecules	13
drug diclofenac	13
acid moiety	13
significant increase	13
ionic liquid	13
vero cell	13
query compound	13
two steps	13
androgen receptor	13
withdrawing group	13
free radical	13
three new	13
showed strong	13
ms ms	13
benzene ring	13
lmqc structures	13
may contribute	13
anticonvulsant agents	13
organic synthesis	13
corylifolia extract	13
promising results	13
cytotoxic properties	13
linear regression	13
may help	13
strong inhibitory	13
hydrogen atom	13
ray crystallographic	13
much lower	13
binding affinities	13
chemical constituents	13
methyl ester	13
significant inhibition	13
drug ciprofloxacin	13
dna replication	13
well known	13
molar refractivity	13
human rhinovirus	13
science group	13
resistant strain	13
acid group	13
oxadiazole derivatives	13
vitro studies	13
attractive target	13
cellular uptake	13
respiratory tract	13
workers synthesized	13
homology modeling	13
chemical properties	13
plaque assay	13
piperazine ring	13
cauline leaves	13
human cervical	13
aminomethyl group	13
human liver	13
superoxide dismutase	13
tyrosine kinase	13
previous work	12
docking poses	12
cells treated	12
compounds will	12
results suggested	12
based fluorescent	12
weak activity	12
much higher	12
mobile phase	12
less cytotoxic	12
bioactivity scores	12
aspergillus flavus	12
functional group	12
cancer activity	12
cancer drug	12
high concentrations	12
induced seizures	12
last years	12
obtained results	12
disease caused	12
homo sapiens	12
direct fl	12
amino groups	12
showed ic	12
variously substituted	12
good agreement	12
phosphate derivatives	12
million people	12
even though	12
structural basis	12
physiological ph	12
ray crystallography	12
valproic acid	12
fold higher	12
based assay	12
energy conformations	12
mitochondrial membrane	12
liver microsomes	12
activities synthesis	12
common cold	12
mice infected	12
melting points	12
chemical shifts	12
disease control	12
derivatives exhibited	12
cell division	12
available drugs	12
patient harm	12
substituted derivatives	12
human cytomegalovirus	12
marine sponges	12
anticancer drug	12
structurally diverse	12
concentration range	12
receptor ligands	12
fold increase	12
binding sites	12
chemical stability	12
whole plant	12
acute toxicity	12
airway epithelial	12
dry dmf	12
derivatives bearing	12
zinc ions	12
cytotoxic activities	12
showed low	12
colorimetric assay	12
factor receptor	12
bioactive molecules	12
coumarin derivative	12
inflammatory mediators	12
inhibitory concentrations	12
reversed chloroquines	12
antifungal compounds	12
multidrug resistant	12
avian influenza	12
monoamine oxidase	12
showed potent	12
plaque formation	12
simulated annealing	12
crystallographic structure	12
medical research	12
one candidate	12
diphenyltetrazolium bromide	12
antimicrobial compounds	12
i values	12
elemental analysis	12
cs co	12
candidate compounds	12
chronic diseases	12
cytotoxicity studies	12
herpes zoster	12
disc diffusion	12
low concentrations	12
antitumor agents	12
viral plaque	12
ki mice	12
many alkaloids	12
training set	12
hybrid compounds	12
secondary amine	12
aspergillus spp	12
viral entry	12
cell entry	12
produced less	12
showed excellent	12
even better	12
orally active	12
inflammatory response	12
electron withdrawing	12
structural similarity	12
sequence alignment	12
new antiviral	12
phase iii	12
much less	12
feline coronavirus	12
novel class	12
aromatic amines	12
significant activity	12
cytotoxic effect	12
crop loss	12
fold superior	11
neutralizing antibodies	11
dna binding	11
potential drugs	11
therapeutic target	11
one study	11
hydroxy group	11
microwave heating	11
ring systems	11
uorinated diazines	11
food products	11
containing diazines	11
secondary amines	11
table i	11
consensus scoring	11
quantum chemical	11
schiff base	11
containing two	11
virus strains	11
novel derivatives	11
phenyl moiety	11
showed selectivity	11
potent inhibitory	11
magnetic resonance	11
protein backbone	11
cycle arrest	11
benzoxazine ring	11
assay using	11
drug ampicillin	11
high cytotoxicity	11
bioactive constituents	11
highest binding	11
pharmacological evaluation	11
therapeutic use	11
coronavirus infection	11
specific inhibitors	11
nh group	11
klebsiella pneumoniae	11
vitro assays	11
glucuronidase inhibitory	11
oxygen atoms	11
docking results	11
carbonic anhydrases	11
cells well	11
preformed fibrils	11
rhesus macaques	11
strong activity	11
distance geometry	11
active sites	11
pestalotiopsis microspora	11
therapeutic applications	11
coworkers prepared	11
anticancer drugs	11
step hydrolysis	11
receptor affinity	11
drug delivery	11
compounds based	11
based drug	11
north america	11
good yields	11
ring nitrogen	11
rat liver	11
mers ma	11
three mannich	11
benzimidazole derivatives	11
causal agent	11
synthetic analogues	11
showed weak	11
ion channels	11
hydroxy groups	11
triazole moiety	11
antibiotic resistance	11
internal standard	11
innate immune	11
enzyme inhibitors	11
potential therapeutic	11
synthetic strategy	11
well tolerated	11
gel chromatography	11
binding modes	11
biological control	11
trifl uoromethyl	11
gel coatings	11
monkey kidney	11
antiviral potency	11
excellent activity	11
methylene group	11
carcinoma cells	11
kj mol	11
human tumor	11
quinolizidine alkaloids	11
exhibited good	11
diabetic patients	11
amyloid proteins	11
compounds inhibited	11
stronger inhibitors	11
antifungal agent	11
compound displayed	11
organic layer	11
target prediction	11
leaf extracts	11
cardiovascular diseases	11
protecting group	11
significantly different	11
fluorine atom	11
phenolic group	11
base derivatives	11
new potential	11
micromolar concentrations	11
atp synthase	11
human plasma	11
type ii	11
acid functionalized	11
viral diseases	11
sea urchin	11
pyrrole mannich	11
novel synthesis	11
using srb	11
chem doi	11
molecular similarity	11
stock solutions	11
dopamine receptor	11
ccr antagonists	11
selective anti	11
transcriptase inhibitors	11
methanol extracts	11
control group	11
bglu inhibitory	11
pot synthesis	11
performance liquid	11
wild type	11
molecular targets	11
antiprotozoal activity	11
new chemical	11
effi cacy	11
binding cavity	11
target product	11
functional food	11
pharmacy compounding	10
endoplasmic reticulum	10
concentration required	10
also identified	10
various concentrations	10
times higher	10
terminal region	10
also able	10
low nanomolar	10
lethal dose	10
acid groups	10
cancer institute	10
molecular interactions	10
bismuth drugs	10
virus ns	10
wound healing	10
diethylene glycol	10
nabh cn	10
benzofuran derivatives	10
chemical synthesis	10
data taken	10
antibiofilm activity	10
predicted metabolic	10
oh unit	10
protein binding	10
pedv replication	10
taken together	10
domain ii	10
different parts	10
coronavirus spike	10
currently used	10
highly potent	10
studies demonstrated	10
boiling point	10
trypanothione reductase	10
spore germination	10
plaque number	10
cell monolayers	10
toro virus	10
may result	10
supplementary data	10
binding domain	10
compounds identified	10
also demonstrated	10
glucosidase inhibitors	10
membrane permeability	10
dipeptidyl peptidase	10
reached phase	10
cytotoxic mannich	10
dna duplex	10
bioactivity score	10
comprehensive review	10
polymerase inhibitors	10
coronavirus main	10
plant material	10
prepared according	10
aqueous media	10
regression equations	10
chlorokojic acid	10
reaction using	10
condensation reaction	10
quinoline derivatives	10
acid side	10
coxsackie virus	10
using different	10
compound causing	10
punta toro	10
head group	10
tumour cells	10
national cancer	10
colletotrichum sp	10
avian flu	10
least potent	10
compound formed	10
coumarin scaffolds	10
main proteases	10
indole alkaloid	10
virus disease	10
health benefits	10
multidrug resistance	10
platelet aggregation	10
derivatives based	10
zika virus	10
new compound	10
fda alerts	10
fcov fipv	10
acid synthesis	10
synergistic effect	10
dna damage	10
treatment options	10
argon atmosphere	10
ca ix	10
effective antiviral	10
hydrophobic interaction	10
ph values	10
anticonvulsant properties	10
parasite plasmodium	10
tinctoria leaves	10
selective inhibition	10
structureeactivity relationship	10
cysteine protease	10
ic nm	10
using two	10
comparative study	10
dried rosette	10
higher concentrations	10
octanol water	10
receptor subtypes	10
randomized clinical	10
hypochlorite ions	10
substrate specificity	10
protein kinases	10
pharmacophore modeling	10
trifl uridine	10
molecular mass	10
cell apoptosis	10
diseases caused	10
inhibit viral	10
recently reported	10
clinical isolates	10
higher selectivity	10
already mentioned	10
bacterial cell	10
selected structures	10
cervical cancer	10
molecules may	10
next step	10
stem cells	10
linoleic acid	10
measured using	10
cervix carcinoma	10
based inhibitors	10
modeling studies	10
density functional	10
crude product	10
bglu inhibitor	10
prepared using	10
morphological changes	10
two novel	10
moiety synthesis	10
hca xii	10
side effect	10
derived bglu	10
signaling pathways	10
aminopeptidase type	10
fold reduction	10
dna minor	10
exhibited potent	10
free energies	10
red blood	10
phenyl rings	10
starting antibiotic	10
withdrawing groups	10
inducing apoptosis	10
various substituents	10
necrosis factor	10
nuclear magnetic	10
benzoic acid	10
human serum	10
genetic algorithm	10
significantly inhibited	10
electron density	10
recent literature	10
hiv integrase	10
different cancer	10
fold greater	10
compound libraries	10
spike glycoprotein	10
antibiotic activity	10
methoxy groups	10
functional theory	10
molecular mechanisms	10
compound sweet	10
protective effect	10
primary screening	10
test sets	10
biological systems	10
ir spectrum	10
drug candidate	10
health effects	10
feature selection	10
rosette leaf	9
fresh leaves	9
two series	9
enhanced production	9
salt bridge	9
large numbers	9
dynamics simulations	9
volatile compounds	9
virus polymerase	9
molecule rofecoxib	9
nucleoside analogs	9
heterocyclic compounds	9
endophytic streptomyces	9
antimicrobial evaluation	9
zoi mm	9
chemokine receptors	9
antiviral compound	9
hcv polymerase	9
via pechmann	9
protein coupled	9
based screening	9
natural antibiotics	9
table shows	9
also displayed	9
ii trials	9
synthesized chromone	9
infected cell	9
resulting mixture	9
charge transfer	9
vivo efficacy	9
mechanistic studies	9
time points	9
microwave assisted	9
transgenic mouse	9
compounds ael	9
hydroxycinnamic acids	9
sindbis virus	9
flash column	9
antiviral action	9
cyclic carbonate	9
coumarin hybrids	9
whereas compounds	9
promising activity	9
alkyl derivatives	9
cell surface	9
may provide	9
chemical reactions	9
compounds act	9
anthracycline antibiotics	9
low energy	9
hit compounds	9
compounds present	9
previously shown	9
lamarckian genetic	9
may lead	9
inhibitory action	9
also potent	9
molecular level	9
dry ch	9
administered orally	9
natural sources	9
lines using	9
alternaria solani	9
research group	9
lung pathology	9
sar analysis	9
malaria parasite	9
secondary products	9
till date	9
liver injury	9
stacking interaction	9
ccr antagonist	9
receptor ligand	9
approved drug	9
mm compared	9
ray crystal	9
similarity searching	9
antifungal properties	9
one hand	9
new approach	9
structural modifications	9
shown promising	9
bait compounds	9
membrane fusion	9
inflammatory effect	9
highly conserved	9
feline herpes	9
regression analysis	9
west nile	9
dipolar cycloaddition	9
qsar study	9
ala group	9
induced cpe	9
organic solvents	9
structural proteins	9
blood cells	9
another important	9
compound concentrations	9
parasite growth	9
analysis showed	9
interesting biological	9
coumarin moiety	9
promising derivatives	9
induced apoptosis	9
methanolic extracts	9
aminomethylated derivatives	9
compounds inhibit	9
aspartic acid	9
simple coumarins	9
carbon atom	9
challenge virus	9
particular interest	9
steroidal alkaloids	9
fungal infections	9
pivot compound	9
leukemia cell	9
fl uorouridine	9
coumarin based	9
clinically useful	9
human african	9
significant influence	9
clinical use	9
nucleoside analogue	9
higher plants	9
compounding error	9
collaborators investigated	9
drug resistant	9
cell walls	9
disease resistance	9
exhibited moderate	9
gause institute	9
red alga	9
vitro study	9
sephadex lh	9
three times	9
structural diversity	9
active center	9
qsar studies	9
positively charged	9
thiazole derivatives	9
two gram	9
potassium hydroxide	9
series showed	9
exhibited excellent	9
values comparable	9
medium supplemented	9
human pathogenic	9
antifungal potency	9
pneumocystis carinii	9
therapeutic options	9
national institute	9
studied bioactive	9
molecular mechanism	9
membrane potential	9
isoforms i	9
similar fashion	9
afl oqualone	9
competitive inhibition	9
pyridine ring	9
nile virus	9
shoot cultures	9
thyroid receptor	9
human subjects	9
alkyl groups	9
molecular connectivity	9
inhibitory potencies	9
nucleophilic attack	9
glucuronidase inhibition	9
data analysis	9
method described	9
bases obtained	9
cytotoxic towards	9
methyl groups	9
screening using	9
colon carcinogenesis	9
folic acid	9
good selectivity	9
toxicity profile	9
products marine	9
metabolic stability	9
root rot	9
fda approved	9
jak inhibitors	9
coumarins showed	9
recent developments	9
also studied	9
cell membranes	9
first reported	9
state university	9
oxidative phosphorylation	9
moment along	9
extracellular cgamp	9
selective cox	9
inhibit chloroquine	9
new therapeutic	9
pharmaceutical compounding	9
promising sars	9
food industry	9
lead optimization	9
another example	9
reaction products	9
neurodegenerative diseases	9
prepared starting	9
cyclic ketones	9
selective activity	9
fluoride ions	9
highly specific	9
hbv activity	9
parkinson disease	9
bond acceptor	9
methionine aminopeptidases	9
following day	9
significant effect	9
new semi	9
specific antiviral	9
uorouracil derivatives	9
melting point	9
nucleocapsid protein	9
viral protein	9
relatively large	9
entry inhibitors	9
good anti	9
hepatoma cells	9
embryonic lung	9
alternative approach	9
two types	9
dichloromethane extracts	9
biocontrol agents	9
peptide core	9
indole moiety	9
similar binding	9
novel coumarin	9
recent study	9
pharmacokinetic profile	9
culture media	9
ex vivo	9
thymidine phosphorylase	9
containing different	9
infectious virus	9
showed less	9
workers focused	9
water soluble	9
reductase inhibitors	9
plant diseases	9
antiviral screening	9
binding pockets	9
vitro antifungal	9
compound series	9
human colon	9
marine compounds	9
drug target	8
also included	8
mmt assay	8
canine kidney	8
glycosidase inhibitors	8
two orders	8
primary amines	8
aminofurazan yl	8
whereas mannich	8
final product	8
liver cancer	8
imidazole ring	8
pseudomonas spp	8
inhibitors compared	8
novel antifungal	8
fungal cells	8
molecular devices	8
derivatives linked	8
identify novel	8
molecular biology	8
chemie gmbh	8
survival rate	8
bond lengths	8
fungal species	8
tba assay	8
molecular electrostatic	8
cross metathesis	8
food sectors	8
lower concentrations	8
two mannich	8
sulfated polysaccharides	8
vitro antibacterial	8
ring opening	8
contamination errors	8
key role	8
fold stronger	8
inhibited virus	8
antiviral ec	8
compounds showing	8
resulting mannich	8
three different	8
showed similar	8
showed inhibitory	8
total synthesis	8
organic phase	8
rega institute	8
medicinal properties	8
relatively low	8
data obtained	8
african green	8
dna topoisomerase	8
several types	8
novel therapeutic	8
drug products	8
phosphonic acid	8
free reactions	8
mic mg	8
substituted piperazines	8
strains compared	8
antiproliferative effect	8
bases showed	8
urgent need	8
double bonds	8
betulin derivatives	8
glycosidic linkage	8
promyelocytic leukemia	8
analyzed using	8
built using	8
viral polymerase	8
respiratory disease	8
fl uoropyrimidine	8
cov main	8
amino moiety	8
similar structures	8
drug molecules	8
small series	8
bioactive components	8
lewis acid	8
showed promising	8
birch bark	8
defense compound	8
incubation period	8
resistant viruses	8
substituted phenols	8
promising antiviral	8
four different	8
biological results	8
graphpad prism	8
hydroxyphenylacetic acid	8
human respiratory	8
indole mannich	8
kojic acid	8
toxic properties	8
peritonitis virus	8
stock solution	8
viral titers	8
group showed	8
review article	8
ppm assigned	8
methanol extract	8
biological effects	8
hydroxamic acid	8
lower cytotoxicity	8
synergic effects	8
brown alga	8
sars cov	8
administration fda	8
domain i	8
significantly increased	8
human coronaviruses	8
concentration errors	8
inhibit human	8
purine nucleoside	8
nanomolar concentrations	8
tumor necrosis	8
selective inhibitory	8
transgenic mice	8
energy value	8
inducing cell	8
gas chromatography	8
micromolar activity	8
safety profile	8
obtained compounds	8
resistant parasites	8
mycorrhizal fungi	8
useful tool	8
biological processes	8
parainfluenza virus	8
inhibition assays	8
number reduction	8
exhibited inhibition	8
logp values	8
reaction conditions	8
derivatives via	8
ml dmem	8
cellular metabolism	8
towards ache	8
recent work	8
point apparatus	8
reaction time	8
triazol yl	8
antiproliferative activities	8
thin layer	8
i clinical	8
presented prominent	8
fold selectivity	8
pe values	8
atomic coordinates	8
diseases including	8
statistical significance	8
guinea pig	8
partial least	8
double hydroxylation	8
kinetic studies	8
control mice	8
chain length	8
high level	8
highly functionalized	8
cervical carcinoma	8
scientific community	8
anticholinesterase activity	8
rich source	8
high mortality	8
stib mouse	8
solid tumors	8
ch oc	8
marine algae	8
cell fusion	8
results also	8
boronic acid	8
cxcr antagonists	8
coupled receptors	8
alkaline hydrolysis	8
i value	8
significant anti	8
may cause	8
develop new	8
pyrazole derivatives	8
compound resulted	8
great potential	8
falciparum strain	8
quantitative analysis	8
neuroprotective activity	8
aerial parts	8
resistance transporter	8
adverse events	8
dilution method	8
potential target	8
inactive compounds	8
hit compound	8
type diabetic	8
comparative analysis	8
compounds include	8
oxidative damage	8
enzyme inhibitory	8
sprout extract	8
literature data	8
provided protection	8
novel antiviral	8
molecular orbital	8
receptor site	8
ray structure	8
drug streptomycin	8
hemorrhagic fever	8
ligand binding	8
novel chemical	8
clpro inhibitors	8
herpes viruses	8
compound using	8
normal human	8
first stage	8
cg ca	8
fold lower	8
different biological	8
fungal diseases	8
showed better	8
increasing interest	8
cc values	8
molecular properties	8
will also	8
early stage	8
ammonium salt	8
rofecoxib structures	8
dopamine receptors	8
exhibited low	8
tested concentration	8
subsequently added	8
relationship study	8
supplementary table	8
ncov main	8
may act	8
pb interaction	8
compounds produced	8
almost completely	8
cancer agents	8
white solid	8
chemical similarity	8
causative agent	8
rat model	8
antiviral evaluation	8
negative control	8
two classes	8
high degree	8
existing drugs	8
several candidates	8
vivo anti	8
directed toward	8
preclinical studies	8
thymidylate synthase	8
fruit antibacterial	8
receptor agonists	8
fret enzyme	8
related gene	8
electron transport	8
also active	8
fungal pathogenesis	8
med chem	8
biological targets	8
tandem mass	8
approach may	8
claisen rearrangement	8
aminomethyl derivatives	8
amide group	8
mic value	8
tinctoria dried	8
nucleoside reverse	8
human use	8
hiv aids	8
clinically used	8
phenol compounds	8
increased potency	8
trypanosomal agents	8
also confirmed	8
small linker	8
chromone scaffold	8
virus rna	8
computational studies	8
active agents	8
activity may	8
antitumor activities	8
values greater	8
autoimmune diseases	8
protein structure	8
biochemical experiments	8
bovine liver	8
connectivity index	8
protein expression	8
screening data	8
influenza infection	8
activity studies	8
various types	8
induced cytopathogenicity	8
nucleoside phosphorylase	8
simulations showed	8
compound exhibits	8
manilkara zapota	8
thyroid hormone	8
four common	8
binding interactions	8
nuclear receptor	8
control cells	8
chemical interactions	8
dimethylglutaric anhydride	8
common bacteria	8
colon adenocarcinoma	8
ifn alfacon	8
antioxidant potential	8
norovirus cl	8
cell permeability	8
tinctoria hairy	8
positive bacterial	8
different length	8
vivo evaluation	8
good inhibitory	8
vitro screening	8
similar compounds	8
less effective	8
generally less	8
antiviral mechanism	8
binding proteins	8
lower activity	8
excellent yields	8
seed extract	8
active form	8
spectroscopic methods	8
well plate	8
chemotherapeutic agent	8
trade name	8
prompted us	8
spectroscopic data	8
dependent kinases	8
many studies	8
inhibition studies	8
hcv replication	8
acetylenic mannich	8
kinase inhibitor	8
tethered isatin	8
catalytic acid	8
antiviral agent	8
generated using	8
culture assays	8
first two	8
certain degree	8
vancomycin aglycone	8
hcv infection	8
antimalarial drugs	8
viral proteases	8
nuclear factor	8
cardiovascular disease	8
biosafety level	8
large quantities	8
potent candidates	8
cancer treatment	8
steric effect	8
ch cn	8
inflammatory process	8
also produced	8
virus titer	8
guided isolation	8
fibril formation	8
possible mechanisms	7
also detected	7
plate reader	7
compounds lmqc	7
infected patients	7
amide function	7
hcv rdrp	7
caspase cascade	7
structural insight	7
biomedical coatings	7
atomic charges	7
virus activities	7
linear relationship	7
potent antifungal	7
also described	7
times lower	7
active components	7
collaborators synthesized	7
japanese horse	7
pdb code	7
ligand complexes	7
virus types	7
crop protection	7
financial support	7
ray structures	7
case study	7
compound inhibits	7
coumarin synthesis	7
highly toxic	7
dose response	7
two phenolic	7
exhibited antiviral	7
viral titre	7
flavonoid seeds	7
gold standard	7
bruker avance	7
different stages	7
th century	7
lg ml	7
polar solvation	7
clinical efficacy	7
bases generated	7
serum albumin	7
soft coral	7
phosphate group	7
new bioactive	7
mg per	7
base moiety	7
moderate anti	7
indian medicinal	7
state analogue	7
dry weight	7
colorectal cancer	7
free synthesis	7
chronic inflammation	7
organic acids	7
brown macroalgae	7
compound possesses	7
colletotrichum gloeosporioides	7
may occur	7
hiv entry	7
therapeutic targets	7
target cells	7
coumarins mentioned	7
ii inhibitors	7
lung carcinoma	7
alkyl side	7
cells via	7
protein complexes	7
calculated based	7
bond formation	7
selective toxicity	7
fungi isolated	7
displayed even	7
inhibit sars	7
synuclein oligomers	7
epidermal growth	7
phenolic profile	7
cells per	7
energy conformation	7
complexes useful	7
data collection	7
plant parts	7
feline corona	7
clinical utility	7
candidates showed	7
significant improvement	7
important biological	7
induced cell	7
including hela	7
bioactive natural	7
exhibited selective	7
different strains	7
aldrich gmbh	7
plant foods	7
compound ig	7
viable cells	7
ytterbium triflate	7
vitro anticancer	7
aliphatic chain	7
cytopathic effects	7
current status	7
nh oh	7
excellent antibacterial	7
alkyne compound	7
radical absorbance	7
activity respect	7
several drugs	7
best profile	7
amide bond	7
hq derivatives	7
acetyl group	7
based derivatives	7
vitro activities	7
enzymatic activity	7
synthetic pathway	7
halogen substitution	7
drug concentration	7
ca xii	7
utah state	7
chemical reactivity	7
blot analysis	7
dual ccr	7
yielded compound	7
urgently needed	7
green algae	7
vehicle control	7
sulfuric acid	7
agar dilution	7
replacement therapy	7
spectrum inhibitors	7
assay system	7
several recent	7
target derivative	7
lysosomal enzymes	7
sulfonamide group	7
azole antifungals	7
rmsd values	7
pechmann reaction	7
therapeutic index	7
microglial cells	7
life technologies	7
untreated wells	7
antioxidant agents	7
novel approach	7
binding ability	7
drugs targeting	7
compounds show	7
fluorescent sensor	7
highest anti	7
time scales	7
also presented	7
hydrochloric acid	7
agar diffusion	7
significant differences	7
polyene macrolides	7
also noteworthy	7
trypan blue	7
pharmacological studies	7
boc group	7
directed ligands	7
terminal amino	7
inhibit virus	7
also performed	7
fresh weight	7
steric hindrance	7
afforded mannich	7
significant difference	7
prothrombin time	7
displayed higher	7
molecular structures	7
plant products	7
groups may	7
compound emerged	7
behloul wu	7
metal chelating	7
values higher	7
several coumarin	7
pyrimidine ring	7
compound dilutions	7
bacterial infections	7
computational methods	7
displayed stronger	7
similar structure	7
competing interests	7
table reports	7
isolated compound	7
authors also	7
compounds derived	7
active towards	7
attention due	7
herpes virus	7
well microtiter	7
peripheral blood	7
insulin resistance	7
crystallographic analysis	7
cell imaging	7
human urine	7
dynamics simulation	7
tfa salts	7
caulerpin molecule	7
hydroxylated derivatives	7
slightly weaker	7
bases i	7
irreversible human	7
substituted isatins	7
tree species	7
glycol tethered	7
different viruses	7
inhibition activities	7
two mutations	7
order predicted	7
tris buffer	7
modified compounds	7
nucleic acids	7
fibroblast cells	7
anticancer agent	7
synthetic procedure	7
compounds found	7
blood glucose	7
protonated piperazine	7
hydroxamic acids	7
per year	7
potential inhibitor	7
corylifolia seeds	7
two decades	7
cycle distribution	7
human ether	7
chromone molecule	7
analysis revealed	7
embryonic kidney	7
antifungal drugs	7
based pharmacophore	7
nonstructural proteins	7
blood levels	7
vitro cytotoxicity	7
future research	7
previously demonstrated	7
reference inhibitor	7
compounds demonstrated	7
contour map	7
disease synthesis	7
raw materials	7
arterial blood	7
structure determination	7
antimicrobial properties	7
extracellular viral	7
examined using	7
horse chestnut	7
protease inhibition	7
therapeutic approach	7
allylic alcohol	7
amide nh	7
two molecules	7
also inhibited	7
xanthine oxidase	7
gastrointestinal tract	7
state analogues	7
glucosidase inhibitor	7
ache buche	7
waste products	7
new method	7
transition metal	7
aryl ring	7
known compounds	7
resistant mcf	7
pyrrole derivatives	7
higher inhibitory	7
final products	7
new generation	7
fusion inhibitors	7
green monkey	7
bulgarian academy	7
pedv inhibitory	7
water extracts	7
gmbh chemie	7
cryptococcus neoformans	7
electron transfer	7
terminally modified	7
pharmacophore model	7
effectively inhibit	7
care professionals	7
acacia catechu	7
lowest concentration	7
wistar rats	7
patients affected	7
diffraction method	7
hydroxycinnamic acid	7
general structure	7
starting antibiotics	7
physicochemical parameters	7
oral therapy	7
cellular targets	7
detailed study	7
methods described	7
small intestine	7
prism software	7
protein biosynthesis	7
remarkable antibacterial	7
vitro inhibition	7
experimental evidence	7
aminopeptidase inhibitors	7
pharmacological profile	7
mast cells	7
protein targets	7
ceric ammonium	7
also effective	7
dry pyridine	7
mercaptoacetic acid	7
low molecular	7
healthy subjects	7
spectrum antibacterial	7
defense mechanisms	7
structureeactivity relationships	7
brucei gambiense	7
halistanol sulfates	7
catalytic amount	7
aryl groups	7
acid composition	7
docking pose	7
therapeutic significance	7
another group	7
virus production	7
distilled water	7
fingers domain	7
decreased activity	7
critical role	7
transcriptase inhibitor	7
crystal violet	7
made using	7
antimicrobial substances	7
brown solid	7
taxol production	7
competitive inhibitors	7
corylifolia linn	7
structural elucidation	7
digestive vacuole	7
antagonistic activity	7
many cases	7
bioactive metabolites	7
large scale	7
showed anti	7
acid glu	7
endothelial cell	7
important source	7
binding protein	7
also isolated	7
technological applications	7
online version	7
ten years	7
molecular formula	7
prolonged release	7
proliferative activities	7
alerts health	7
cell lung	7
scientific literature	7
crevicular fluid	7
probably due	7
ferulago cassia	7
catalytic activity	7
well diffusion	7
coupling reaction	7
induced inflammation	7
bioisosteric replacement	7
ann arbor	7
compounds including	7
secondary structure	7
antiviral strategies	7
cellular toxicity	7
sulfonate derivatives	7
colorless oil	7
phenyl group	7
plant cell	7
corresponding piperidinols	7
compound acts	7
significative antibiofilm	7
synthesized derivatives	7
nonsteroidal anti	7
genetic engineering	7
binding assay	7
real time	7
antimicrobial screening	7
safety profiles	7
strong binding	7
food samples	7
based approaches	7
type virus	7
active compared	7
four new	7
type reaction	7
compounds also	7
research foundation	7
single molecule	7
liver bglu	7
protonated nitrogen	7
cancer types	7
therapeutic intervention	7
show activity	7
effective concentrations	7
anticonvulsant activities	7
inhibitor activity	7
compounds exhibit	7
protein interaction	7
intravenous administration	7
uorine atom	7
substituted analogues	7
influenza activity	7
cb receptor	7
may produce	7
carbonyl function	7
santa cruz	7
colon carcinoma	7
point mutations	7
viral genome	7
flow cytometry	7
new endophytic	7
second generation	7
malaria parasites	7
metabolic activation	7
liver metabolism	7
showed characteristic	7
donating groups	7
th position	7
inside lu	7
sequence similarity	7
allowed us	7
vivo imaging	7
administered i	7
diazonium salt	7
bioactive compound	7
murine model	7
medicinal applications	7
strongest inhibitor	7
human diseases	7
cleavage sites	7
human hepatoma	7
exhibited inhibitory	7
darby canine	7
biological studies	7
heterocyclic rings	7
virus adsorption	7
starting materials	7
showed significative	7
maximal inhibitory	7
chromone ring	7
untreated controls	7
microdilution method	7
different factors	7
concentration tested	7