Questions

This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.

identifier question
cord-002237-200ondzxthe'latest resort'?
cord-003341-z5w56zeqThe case for the multifunctional NS3 protein from dengue virus as a target Strategies for development of dengue virus inhibitors Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control; World Health Organization Protective efficacy of the recombinant, live- attenuated, CYD tetravalent dengue vaccine in thai schoolchildren: A randomised, controlled phase 2b trial Dengue vaccine development: A 75% solution?
cord-000536-0mn1gbllGiven a compound, how can we effectively predict its biological function?
cord-012773-wtgk2d68Why should we use multifunctional neuroprotective and neurorestorative drugs for Parkinson's disease?
cord-012773-wtgk2d68if so how long is it?
cord-013387-q91052qwTowards prediction paradise?
cord-013387-q91052qwWhat Is Known and What Is Next?
cord-034363-6uscua0yBeyond monoamines Pathophysiology of depression: Do we have any solid evidence of interest to clinicians?
cord-016425-8yd2bkf1In other words, why continue to do the same thing when robots, combinatorial chemistry, and molecular biology have arrived on the scene?
cord-016425-8yd2bkf1Where are the undescribed fungi?
cord-016425-8yd2bkf1can ecology provide new leads in the search for novel bioactive chemicals from rainforests?
cord-270123-m8utyd1mbe harmful in coronavirus disease 2019( COVID-19) treatment?
cord-023284-i0ecxgus( Asn- Ala- Asn- Pro) which is a major immunogenic epitope in the circumsporozoite( CS) protein of Plasmodium falciparum Conformational analysis Dream or reality?
cord-023284-i0ecxgusMetalloproteins as chemoreceptors?
cord-023284-i0ecxgusThe program system allows for SCF level treatments of energy, first- and second- order derivatives with respect to nuclear coordinates, and an evaluation of the ME?
cord-025119-201ac32tA trial of lopinavir- ritonavir in adults hospitalized with severe covid-19 Is it reliable to take the molecular docking top scoring position as the best solution without considering available structural data?
cord-025119-201ac32ta tool for high- throughput crystallography of protein- ligand complexes QSAR modelling of rat acute toxicity on the basis of PASS prediction SwissADME: a free web tool to evaluate pharmacokinetics, drug- likeness and medicinal chemistry friendliness of small molecules Optimized hydrophobic interactions and hydrogen bonding at the target- ligand interface leads the pathways of drug- designing LigRMSD: a web server for automatic structure matching and RMSD calculations among identical and similar compounds in protein- ligand docking World Health Organization declares global emergency: a review of the 2019 novel coronavirus( COVID-19) New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
cord-273372-69rlh9orAnd yet we began to wonder, why has there been relatively little focus on small molecules apart from a recent review of Ebola virus therapeutic strategies in general 9?
cord-024652-4i6kktl0( Theobroma cacao L.) Effect of salicylic acid and structurally related compounds in the accumulation of phytoalexins in cotyledons of common bean Phenylphenalenone phytoalexins, will they be a new type of fungicide?
cord-024652-4i6kktl0-France Induce systemic resistance and promotion of plant growth by Bacillus spp Antifungal activity of pisiferic acid derivatives against the rice blast fungus Functional moiety for the antifungal activity of phytocassane E, a diterpene phytoalexin from rice Phytoalexin induction in the sapwood of plants of the Maloideae( Rosaceae): biphenyls or dibenzofurans Structural and functional characterization of gene clusters directing non- ribosomal synthesis of bioactive lipopeptides in Bacillus amyloliquefaciens strain FZB42 Evaluation of essential oils and their components for broad- spectrum antifungal activity and control of late leaf spot and crown rot diseases in peanut Bryophytes, a potent source of drugs for tomorrow's medicine?
cord-024652-4i6kktl0The biocontrol effect of mycorrhization on soil borne fungal pathogens and the autoregulation of the AM symbiosis: one mechanism, two effects?
cord-024652-4i6kktl0The endogenous elicitor, a fragment of a plant cell wall polysaccharide that elicits phytoalexin accumulation in soybeans Tit for tat?
cord-024652-4i6kktl0What is the significance of the arbuscular mycorrhizal colonisation of many economically important crop plants?
cord-317628-1inxq7t5What Are We Talking About?
cord-021013-xvc791wxBut what is the situation after herbivory?
cord-021013-xvc791wxHow do plants defend themselves against microorganisms( including bacteria, fungi, and viruses), herbivores, and plants?
cord-021013-xvc791wxHow is this achieved?
cord-021013-xvc791wxSince Na'is already limited in plant food( an antiherbivore device?), long- term exposure to diuretic compounds would reduce the fitness of an herbivore substantially.
cord-021013-xvc791wxWhat then is their evolutionary solution?
cord-323479-vlgv3nwqA property common to most CDK inhibitors?
cord-261170-arnwk287If you were required to evaluate an extract for its potential as a drug, what approach would you adopt?
cord-261170-arnwk287The exploitation of an old natural resource with sustainable and novel methods Marine natural products: A new wave of drugs?
cord-261170-arnwk287and what are we bioprospecting?
cord-283301-adjjkqt2: where are we?
cord-283301-adjjkqt2A Malaysian experience Is b- glucuronidase a clinical useful biomarker for an acute organophosphorus poisoning?
cord-283301-adjjkqt2plasma b- glucuronidase a novel human biomarker for monitoring anticholinesterase pesticides exposure?
cord-327946-mqakaisainfluenza viruses circulating in humans Influenza A virus recycling revisited In vivo characterization of avian influenza a( H5N1) and( H7N9) viruses isolated from canadian travelers Antiviral Treatments Drugs for Influenza Treatment: Is There Significant News?
cord-320591-re99v1qtHow circular will you eat?
cord-320591-re99v1qtWhich approach is more effective in the selection of plants with antimicrobial activity?
cord-326922-bajpr5a2: where are we heading?
cord-326922-bajpr5a2An outbreak of postoperative gram- negative bacterial endophthalmitis associated with contaminated trypan blue ophthalmic solution Eye opening: are compounded drugs causing harm?
cord-326922-bajpr5a2Compounding pharmacies: a viable option, or merely a liability?
cord-326922-bajpr5a2Time for compounding certification?
cord-326922-bajpr5a2United States Food and Drug Administration United States Food and Drug Administration Compounded drugs: are customized prescription drugs a salvation, snake oil, or both?
cord-352844-wggg3ynb: Where are we?
cord-352844-wggg3ynbNovel therapeutic applications for inhibitors and activators Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
cord-352844-wggg3ynbSignal transducer and activator of transcription-3, inflammation and cancer: How intimate is the relationship?
cord-352844-wggg3ynbThe smart drug delivery system and its clinical potential Light- triggered release of photocaged therapeutics- Where are we now?
cord-352844-wggg3ynbWhen can ionic liquids be considered readily biodegradable?
cord-352844-wggg3ynbcomplex Copper(II) complexes of coumarin- derived Schiff base ligands: Pro- or antioxidant activity in MCF-7 cells?
cord-296560-ehrww6uuA critical assessment of docking programs and scoring functions Predicting protein- ligand binding affinities: a low scoring game?
cord-296560-ehrww6uuAs soon as a relationship between molecular representation and a particular property's values is established a crucial question arises: how good are predictions for novel molecules?
cord-296560-ehrww6uuAssessing model fit by cross- validation Chance correlation in variable subset regression: influence of the objective function, the selection mechanism, and ensemble averaging The problem of overfitting The better predictive model: high q(2) for the training set or low root mean square error of prediction for the test set?
cord-296560-ehrww6uuCan cell systems biology rescue drug discovery?
cord-296560-ehrww6uuHow does consensus scoring work for virtual library screening?
cord-296560-ehrww6uuHow to represent molecular structure( the connectivity table or the coordinates of atoms are not per se suitable choices)?
cord-296560-ehrww6uuStill, in order to establish confidence in models in practical settings, this requirement can be replaced by the question: Which area of chemical space is covered with acceptable error?
cord-296560-ehrww6uuWhat is the functional form between structure( or rather structural representation) and the property under consideration so that we can derive an empirical measure of similarity?