trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
central nervous system	1226
in the cns	1003
as well as	991
the central nervous	767
cd t cells	707
the presence of	690
in patients with	591
in the brain	591
the role of	545
cells in the	444
the development of	409
in multiple sclerosis	409
the expression of	407
of the cns	389
the absence of	386
results suggest that	357
the use of	348
the number of	326
of patients with	319
of multiple sclerosis	313
been shown to	312
in the central	308
one of the	306
the spinal cord	303
within the cns	291
the effects of	286
is associated with	283
in response to	282
in this study	279
the pathogenesis of	276
these results suggest	276
the most common	276
in the absence	275
role in the	268
experimental autoimmune encephalomyelitis	266
in order to	262
into the cns	261
of the disease	260
mouse hepatitis virus	258
of the central	252
the present study	245
the cns of	245
t cells in	244
we found that	244
in addition to	243
has been shown	241
the effect of	237
the treatment of	235
it has been	231
cd t cell	231
involved in the	230
infection of the	230
of the brain	227
a variety of	222
to the cns	222
a role in	221
a number of	217
at day p	213
due to the	213
myelin basic protein	212
clinical signs of	211
west nile virus	206
in the present	198
the risk of	189
the majority of	187
based on the	186
and spinal cord	184
the nervous system	184
the induction of	183
has been reported	181
an important role	176
the cns and	175
is characterized by	174
in the presence	172
the brain and	171
graduate school of	171
mhc class i	170
are associated with	169
the course of	169
suggest that the	168
to determine the	166
neurons in the	166
associated with a	165
expression of the	164
an increase in	164
be associated with	164
severe acute respiratory	161
observed in the	161
found in the	160
of cd t	160
has not been	160
associated with the	159
there is a	159
because of the	159
acute respiratory syndrome	158
as a result	158
the time of	156
the immune response	156
on the other	156
the onset of	155
the diagnosis of	155
the immune system	154
play a role	153
in the pathogenesis	153
in contrast to	153
have shown that	152
there was no	152
contribute to the	152
cells of the	152
spinal cord injury	152
the level of	151
t cell responses	151
cd and cd	150
mice infected with	150
in the spinal	150
the other hand	149
united states background	148
important role in	148
and in the	145
results indicate that	142
there is no	141
tumor necrosis factor	141
t cells are	141
the importance of	140
expression in the	140
well as the	139
school of medicine	138
of the virus	138
at the time	136
depending on the	136
part of the	135
the activation of	135
of the patients	134
of the immune	134
changes in the	132
of t cells	132
and cd t	132
be involved in	131
t cells and	131
patients with ms	131
mhc class ii	131
been associated with	130
has also been	130
detected in the	130
specific t cells	130
increase in the	130
have been reported	129
analysis of the	129
a patient with	128
borna disease virus	127
in the rat	127
in children with	125
a result of	124
in cases of	124
from the cns	124
shown to be	123
found to be	123
the production of	122
experimental allergic encephalomyelitis	122
the severity of	122
respiratory syndrome coronavirus	121
present in the	119
can be used	119
data suggest that	119
the regulation of	119
to be a	118
in the csf	118
brain and spinal	117
been reported in	116
was observed in	116
the cns is	115
specific cd t	115
such as the	114
we examined the	114
expressed in the	114
of this study	113
was associated with	113
is involved in	112
in the hippocampus	112
is the most	112
to investigate the	110
of ms patients	110
in the adult	109
have been shown	109
in vitro and	107
role of the	107
for the treatment	106
may contribute to	106
the control of	106
in a dog	105
infection in the	105
in some cases	104
by day p	104
nitric oxide synthase	104
virus infection in	104
mg kg iv	104
the incidence of	104
is important to	103
this study was	103
appears to be	103
the ability of	103
magnetic resonance imaging	102
in ms patients	102
related to the	102
have also been	102
cd c microglia	102
c bl mice	102
a total of	101
is thought to	101
the formation of	100
in the development	100
is one of	100
most of the	100
the olfactory bulb	99
t cells were	99
to evaluate the	99
it is important	99
these results indicate	99
the frequency of	98
compared to the	98
years of age	98
we investigated the	97
is required for	96
it is possible	96
we show that	95
are involved in	95
the white matter	94
in the treatment	94
but not in	94
in which the	94
the lack of	94
according to the	94
to the brain	94
was detected in	94
of mouse hepatitis	93
and in vivo	93
may be a	93
with multiple sclerosis	93
the case of	93
of these cells	93
a role for	93
the extent of	92
the function of	92
of the most	91
was found to	91
the context of	91
activation of the	91
for multiple sclerosis	91
tcr transgenic mice	91
is essential for	91
t cell response	90
the levels of	90
the site of	90
herpes simplex virus	90
can lead to	89
data not shown	89
the brain of	89
be used to	89
entry into the	89
high levels of	89
patients with covid	88
the amount of	88
there was a	88
isolated from the	88
to study the	87
have not been	87
be due to	87
consistent with the	87
feline infectious peritonitis	87
major histocompatibility complex	86
in the developing	86
the ability to	86
the fact that	86
into the brain	86
to assess the	86
study was to	86
the end of	85
cd foxp tregs	85
the united states	85
in the dog	84
was used to	84
in the context	84
responsible for the	84
some of the	84
to determine whether	84
findings suggest that	84
play an important	84
were found to	84
appear to be	84
of the blood	83
been reported to	83
is known to	83
with or without	83
thought to be	83
immune response to	83
in the mouse	83
the degree of	83
have been described	82
in situ hybridization	82
these data suggest	82
were observed in	81
the process of	81
known to be	81
for patients with	81
to have a	81
a decrease in	81
of microglia in	81
is possible that	81
of the spinal	81
the possibility that	81
the generation of	81
gene expression in	81
vitro and in	81
were found in	81
of spinal cord	80
the inflammatory response	80
murine encephalomyelitis virus	79
peripheral nervous system	79
nervous system of	79
to play a	79
the addition of	79
to understand the	79
sickle cell disease	78
from patients with	78
in the early	78
a diagnosis of	78
nile virus infection	78
animal models of	78
as compared to	78
the brains of	78
respiratory syncytial virus	78
is based on	78
the release of	78
the cerebrospinal fluid	77
the patient is	77
cells within the	77
balb c mice	77
than in the	76
of mice with	76
was found in	76
well as in	76
may play a	76
the involvement of	76
multiple sclerosis patients	76
a series of	76
dogs and cats	75
a combination of	75
resulted in a	75
in the same	75
the relationship between	75
region of the	74
astrocytes and microglia	74
in the case	74
the cause of	74
microglia in the	74
and multiple sclerosis	74
may not be	74
studies have shown	74
more likely to	74
in a patient	74
in the united	73
induced demyelinating disease	73
of experimental autoimmune	73
in most cases	73
can also be	73
review of the	73
showed that the	73
c hi monocytes	73
has been used	73
these findings suggest	72
east respiratory syndrome	72
should be considered	72
pediatric patients with	72
model of multiple	72
mg kg po	72
is known about	71
of nitric oxide	71
the aim of	71
morbidity and mortality	71
infections of the	71
to be the	71
were used to	70
understanding of the	70
it is not	70
to the development	70
middle east respiratory	70
microglia and astrocytes	70
virus in the	70
spinal cord of	70
when compared to	69
similar to the	69
the activity of	69
little is known	69
in the human	69
the detection of	69
the cns during	69
in the first	69
and can be	69
the surface of	69
member of the	69
university of tokyo	69
of nk cells	69
the csf of	68
results in a	68
patients with multiple	68
the rate of	68
in the blood	68
involvement of the	68
the need for	68
the cns in	68
has been associated	68
a model of	68
in dogs with	68
in the regulation	68
in the peripheral	67
the study of	67
in terms of	67
in mice infected	67
of the human	67
were treated with	67
we conclude that	67
the possibility of	67
ifnar fl fl	67
a critical role	67
mouse model of	67
a neurotropic coronavirus	67
been implicated in	67
damage to the	66
is an important	66
memory t cells	66
in the nervous	66
of children with	66
lesions in the	66
are known to	66
human immunodeficiency virus	66
in the literature	66
seen in the	66
in combination with	66
used as a	66
the age of	66
to determine if	65
department of physiology	65
cells from the	65
differences in the	65
the results of	65
the proportion of	65
in cats with	65
in the cerebrospinal	65
can result in	65
at the same	65
quality of life	64
acute and chronic	64
diseases of the	64
of cd c	64
the purpose of	64
to identify the	64
response in the	64
cells isolated from	64
a mouse model	64
of cats with	64
the percentage of	64
in spinal cord	63
and may be	63
regions of the	63
may be associated	63
multiple sclerosis and	63
is a rare	63
the form of	63
adoptive transfer of	63
is expressed in	63
has been demonstrated	63
spinal cord and	63
of borna disease	63
in the spleen	63
the identification of	63
lymphocytic choriomeningitis virus	63
risk factors for	63
astrocytes in the	63
of central nervous	62
suggests that the	62
indicate that the	62
in dogs and	62
of the patient	62
followed by a	62
the loss of	62
response to the	62
our results suggest	62
increased expression of	62
were detected in	62
in pediatric patients	62
in the cat	62
the type of	62
sr t cells	62
effect on the	62
are capable of	62
at least one	62
found to have	62
the progression of	62
likely to be	62
of the nervous	61
patients with severe	61
the accumulation of	61
has been suggested	61
significant increase in	61
hematopoietic stem cell	61
there are no	61
found that the	61
the bone marrow	61
may lead to	61
similar to that	61
demonstrated that the	61
may also be	61
the mechanism of	61
the recruitment of	61
nervous system in	61
is due to	61
virus from the	60
characterized by a	60
amyotrophic lateral sclerosis	60
the distribution of	60
suggesting that the	60
the brain parenchyma	60
of cases of	60
stem cell transplantation	60
blood brain barrier	60
glial fibrillary acidic	60
increased risk of	60
has been described	60
that can be	59
a group of	59
correlated with the	59
nervous system and	59
fibrillary acidic protein	59
cells into the	59
a reduction in	59
in the olfactory	59
human coronavirus oc	59
derived from the	59
considered to be	59
in experimental autoimmune	59
the contribution of	59
in the control	59
s of s	59
a study of	59
the university of	59
neural stem cells	59
course of the	59
cerebrospinal fluid of	59
been described in	59
retrospective chart review	59
are present in	58
the cerebral cortex	58
a case of	58
may result in	58
t cells from	58
no evidence of	58
t cells to	58
will be discussed	58
by flow cytometry	58
due to a	58
of dogs with	58
in the form	58
were able to	58
the impact of	58
were associated with	58
the result of	58
mutations in the	57
of t cell	57
in the pediatric	57
risk of developing	57
critical role in	57
of mhc class	57
type i interferon	57
the occurrence of	57
multiple sclerosis lesions	57
of clinical signs	57
presence of a	57
at the end	57
their ability to	57
viral infection of	57
mbp tcr transgenic	57
a retrospective study	56
polymerase chain reaction	56
reduction in the	56
reported to be	56
with a neurotropic	56
in a cat	56
virus infection of	56
cd c t	56
the migration of	56
for min at	56
in relation to	56
ly c hi	56
are able to	56
a review of	56
is the first	56
in this model	55
may be present	55
there were no	55
patients with scd	55
responses in the	55
be related to	55
immune response in	55
the administration of	55
fl fl mice	55
resulting in a	55
results in the	55
infection of mice	55
of the viral	54
to that of	54
in the brains	54
and treatment of	54
a systematic review	54
to examine the	54
and activation of	54
in the periphery	54
also known as	53
the prevalence of	53
effects of the	53
are found in	53
the hypothesis that	53
is a common	53
can be administered	53
autoreactive t cells	53
located in the	53
is consistent with	53
receptors in the	53
activity in the	53
disease of the	53
of these patients	53
many of the	53
access to the	53
of microglia and	53
in the white	53
we have previously	53
led to the	53
reactive t cells	52
remains to be	52
that has been	52
bone marrow transplantation	52
depends on the	52
monocyte chemoattractant protein	52
this is the	52
is able to	52
and bone marrow	52
progressive multiple sclerosis	52
within the brain	52
inducible nitric oxide	52
aim of this	52
a subset of	52
mg kg day	52
the management of	52
is mediated by	52
it may be	52
enter the cns	52
surface of the	52
in the expression	52
of the myelin	52
see section on	51
after spinal cord	51
data indicate that	51
within the central	51
large number of	51
in animal models	51
levels of il	51
addition to the	51
during the first	51
as a potential	51
regulatory t cells	51
need to be	51
acute lymphoblastic leukemia	51
months of age	51
class i and	51
associated with increased	51
used in the	51
disruption of the	51
of infectious virus	51
levels in the	51
end of the	51
was shown to	51
is dependent on	51
a significant increase	50
plays an important	50
with respect to	50
characterization of the	50
is supported by	50
of the chemokine	50
a member of	50
similar to those	50
the initiation of	50
components of the	50
a history of	50
spinal cords of	50
the increase in	50
half of the	50
for treatment of	50
cytokines and chemokines	50
semliki forest virus	50
the patient was	50
for the development	50
activation of microglia	50
referred to as	50
on the surface	49
the substantia nigra	49
development of a	49
the efficacy of	49
purpose of this	49
into the central	49
of the first	49
patients with a	49
the influence of	49
are the most	49
with and without	49
adaptive immune responses	49
with a median	49
of the same	49
that in the	49
in the study	49
only in the	49
function of the	49
control of the	49
the pathophysiology of	49
have been used	49
be responsible for	49
it can be	49
a minimum of	49
and function of	48
are responsible for	48
infected with a	48
the brain stem	48
the basis of	48
could not be	48
a and b	48
been detected in	48
in a variety	48
of astrocytes in	48
national institute of	48
innate and adaptive	48
was determined by	48
transforming growth factor	48
the patients with	48
to elucidate the	48
which may be	48
ctl escape mutants	48
compared to control	48
diseases such as	48
some of these	48
in association with	48
the duration of	48
of glial cells	48
of the inflammatory	48
that there is	48
are required for	48
and characterization of	48
ccr and ccr	47
of the rat	47
s pediatr radiol	47
cytotoxic t lymphocytes	47
did not affect	47
the mechanisms of	47
remitting multiple sclerosis	47
change in the	47
development of the	47
nature of the	47
in the number	47
with sickle cell	47
occur in the	47
the cns by	47
of bone marrow	47
may be necessary	47
university school of	47
of the cases	47
it is also	47
university graduate school	47
level of the	47
in the cerebral	47
is regulated by	47
is caused by	47
is critical for	47
compared with the	47
plays a role	47
the existence of	47
the outcome of	46
to mg kg	46
suggested that the	46
associated with an	46
to be associated	46
the potential to	46
was assessed by	46
the differentiation of	46
traumatic brain injury	46
disease in the	46
with regard to	46
in these patients	46
can be performed	46
is responsible for	46
of the host	46
is not known	46
of west nile	46
reported in the	46
c t cells	46
is important for	46
did not show	46
in the right	45
specific t cell	45
been suggested that	45
immune responses to	45
is a major	45
increased in the	45
the same time	45
there is an	45
the evaluation of	45
in children and	45
and chemokine receptors	45
the vast majority	45
the disease is	45
may be required	45
acute disseminated encephalomyelitis	45
been shown that	45
the combination of	45
more than of	45
none of the	45
supported by the	45
of neurons in	45
mice treated with	45
our understanding of	45
the most important	45
the cell surface	45
to be involved	45
activation in the	45
be considered in	44
show that the	44
results show that	44
chemokines and chemokine	44
this suggests that	44
in the past	44
be used as	44
factors such as	44
required for the	44
the inhibition of	44
caused by a	44
the magnitude of	44
in the induction	44
in the course	44
phase of the	44
are needed to	44
can be induced	44
identification of a	44
perform orogastric lavage	44
seems to be	44
a crucial role	44
in a mouse	44
as previously described	44
contrast to the	44
t cells have	44
in cerebrospinal fluid	44
early stages of	44
progressive multifocal leukoencephalopathy	44
the olfactory epithelium	44
in the ca	44
all of the	43
and it is	43
low levels of	43
risk factor for	43
of immune cells	43
glial cells in	43
have been found	43
science and technology	43
should not be	43
of the risk	43
examination of the	43
it was found	43
in the diagnosis	43
white matter of	43
have been associated	43
a large number	43
infiltration into the	43
lead to the	43
expression of a	43
mgfapcre ifnar fl	43
have been identified	43
evaluation of the	43
b cells in	43
the cns parenchyma	43
which is a	43
of ms is	43
following infection with	43
the innate immune	43
of the mouse	43
murine hepatitis virus	43
had no effect	43
animal model of	43
are thought to	43
in transgenic mice	43
is necessary for	43
decrease in the	43
use of a	43
cell response to	43
no effect on	43
ccr cd foxp	43
have been implicated	42
give rise to	42
at the site	42
areas of the	42
we hypothesized that	42
and t cell	42
we analyzed the	42
that have been	42
strains of mice	42
members of the	42
evidence suggests that	42
the t cell	42
the gastrointestinal tract	42
from the brain	42
a key role	42
immune responses in	42
analysis was performed	42
cell responses in	42
should be performed	42
cytotoxic t cells	42
was supported by	42
in vivo and	42
been found to	42
of a novel	42
of the literature	42
not appear to	42
by administration of	42
in the normal	42
in comparison to	42
of viral replication	42
t cell clones	42
included in the	42
on the basis	42
recent studies have	42
is believed to	42
up to of	42
in the cerebellum	42
of the left	42
stimulation of the	42
only a few	41
t cell proliferation	41
a recent study	41
especially in the	41
participate in the	41
characterized by the	41
been used to	41
a retrospective chart	41
the cns through	41
in the hippocampal	41
in conjunction with	41
clinical characteristics of	41
t cell receptor	41
has been observed	41
are expressed in	41
of the bbb	41
and severity of	41
acts as a	41
myelin oligodendrocyte glycoprotein	41
has been proposed	41
revealed that the	41
and in vitro	41
case of a	41
regulation of the	41
dogs with lymphoma	41
of viral infections	41
of activated charcoal	41
a range of	41
this is a	40
for at least	40
clinical features of	40
difference in the	40
nervous system during	40
wide range of	40
mice were infected	40
in both the	40
is needed to	40
matter of the	40
t cells that	40
replication in the	40
brain science institute	40
a consequence of	40
type i ifn	40
white blood cell	40
is related to	40
different types of	40
it is likely	40
days after the	40
to the central	40
in the dorsal	40
positron emission tomography	40
may be due	40
to increase the	40
the appearance of	40
for the presence	40
in both groups	40
be found in	40
acute respiratory distress	40
the myelin sheath	40
nucleus of the	40
be caused by	40
viral infections of	40
th and th	40
and that the	40
have demonstrated that	40
to analyze the	40
was found that	39
to clarify the	39
activated t cells	39
needs to be	39
neurons of the	39
and has been	39
lower respiratory tract	39
shown that the	39
respiratory distress syndrome	39
role of cd	39
t cell activation	39
mice deficient in	39
more common in	39
during the course	39
allergic encephalomyelitis in	39
vast majority of	39
can be detected	39
the nature of	39
specific for the	39
compared to controls	39
we performed a	39
one or more	39
prior to the	39
portion of the	39
and tumor necrosis	39
in the left	39
also been reported	39
and spinal cords	39
and the presence	39
demyelination induced by	39
occurs in the	39
caused by the	39
cells have been	39
the most frequent	39
the cns are	39
demyelination in mice	39
of a patient	39
of severe acute	39
cell death in	39
the acute phase	39
known about the	39
in a model	38
than that of	38
of myelin basic	38
glial cells and	38
a major role	38
the interaction of	38
infection with a	38
and their receptors	38
mice compared to	38
role of microglia	38
and adaptive immune	38
the blood brain	38
the association of	38
in wt mice	38
at the level	38
may be involved	38
the etiology of	38
activity of the	38
be able to	38
kg po q	38
all patients with	38
onset of the	38
is important in	38
japanese encephalitis virus	38
is difficult to	38
a case report	38
of proinflammatory cytokines	38
cells and macrophages	38
by t cells	38
we have shown	38
to be more	38
an animal model	38
be used in	38
and glial cells	38
in patients who	38
the in vivo	38
chemokine receptors in	38
for use in	38
was performed on	38
which can be	38
cause of the	38
to describe the	38
in of the	38
has been found	38
response to a	38
the analysis of	38
of the major	38
the peripheral nervous	38
to reduce the	38
reactive oxygen species	38
and maintenance of	38
the emergence of	37
believed to be	37
and loss of	37
cells and the	37
contributes to the	37
cell responses to	37
was confirmed by	37
structure of the	37
have been developed	37
highly expressed in	37
are consistent with	37
the application of	37
roles in the	37
in support of	37
a wide range	37
the corpus callosum	37
of rnase l	37
the rat brain	37
class i expression	37
in ms lesions	37
as determined by	37
and found that	37
cytokines such as	37
has been identified	37
were present in	37
of white matter	37
was the most	37
multiple sclerosis the	37
cells in vitro	37
macrophage inflammatory protein	37
increased levels of	37
cd th cells	37
the establishment of	37
stohlman et al	37
of inflammatory cells	37
implicated in the	37
is present in	37
we showed that	37
was performed using	36
leads to a	36
natural killer cells	36
chronic demyelinating disease	36
was performed in	36
cells derived from	36
signs and symptoms	36
in humans and	36
can be seen	36
are believed to	36
approved by the	36
levels of the	36
location of the	36
associated with sars	36
treatment of ms	36
the pattern of	36
of the olfactory	36
may be helpful	36
for h at	36
the potential for	36
likely to have	36
flow cytometric analysis	36
of chemokines and	36
due to their	36
many of these	36
a dog with	36
by the presence	36
mice at day	36
the dentate gyrus	36
cell adhesion molecule	36
coronavirus infection of	36
in many cases	36
a lineage cells	36
weeks of age	36
basic protein and	36
be detected in	36
demyelination in the	36
of b cells	36
days and p	36
in astrocytes and	36
studies suggest that	36
were shown to	36
yet to be	36
of infected mice	36
with a high	36
the molecular mechanisms	36
this study is	36
and expression of	36
children with scd	36
mechanism of action	35
presence of the	35
to enter the	35
of the cd	35
as in the	35
mechanisms by which	35
in this context	35
compared to those	35
of experimental allergic	35
the olfactory nerve	35
the roles of	35
stem cell transplant	35
be used for	35
we used a	35
nervous system infection	35
by means of	35
effects on the	35
it is a	35
who presented with	35
viral replication in	35
the cns via	35
and young adults	35
in the serum	35
were infected with	35
of the two	35
dependent on the	35
mutation in the	35
to viral infection	35
the idea that	35
model of ms	35
study of the	35
should be used	35
important roles in	35
red blood cells	35
essential for the	35
were stained with	35
as part of	35
and b cells	35
elevated levels of	35
all of these	35
patients in the	35
the pediatric population	35
in the disease	35
these cells are	35
total number of	35
macrophages in the	35
seem to be	35
of the lesion	35
be important in	35
at our institution	35
infections in the	35
studies indicate that	35
we propose that	35
pathogenesis of ms	35
of infected cells	35
induced by the	35
to note that	35
memory cd t	35
cd b cells	35
there have been	35
size of the	34
of cd foxp	34
is induced by	34
acute myeloid leukemia	34
function in the	34
based on a	34
of demyelinating disease	34
of viral rna	34
also been shown	34
it is unclear	34
serve as a	34
in some patients	34
used for the	34
because of its	34
the optic nerve	34
in balb c	34
are likely to	34
are characterized by	34
macrophages and microglia	34
examined the effects	34
expression of mhc	34
but also in	34
innate immune response	34
was able to	34
at room temperature	34
median age of	34
been observed in	34
evidence for the	34
crucial role in	34
for more than	34
of the clinical	34
a lack of	34
results demonstrate that	34
nervous system the	34
patients treated with	34
in this review	34
the size of	34
but it is	34
there has been	34
a model for	34
for the first	34
in accordance with	34
as early as	34
influenza a virus	34
can be associated	34
was treated with	34
a change in	34
was used for	34
findings indicate that	34
in the setting	34
are related to	34
was present in	34
and number of	34
may have a	34
not yet been	34
of the study	34
is likely that	34
middle cerebral artery	34
properties of the	34
the capacity of	34
chemokines in the	34
or in the	34
were obtained from	34
wide variety of	34
diagnosis of ms	34
higher in the	33
a wide variety	33
restricted to the	33
expression of cd	33
in a study	33
that of the	33
mediated by the	33
spinal cords were	33
necessary for the	33
signs associated with	33
is required to	33
the peripheral blood	33
the setting of	33
of patients who	33
chemokine receptor ccr	33
the chemokine receptor	33
can be a	33
aspects of the	33
disease caused by	33
it was shown	33
from ms patients	33
per cent of	33
between the two	33
ido ko mice	33
of the right	33
significantly higher in	33
in the cortex	33
cns of mice	33
of the t	33
results in an	33
which has been	33
could be a	33
mouse models of	33
of inflammatory cytokines	33
in the liver	33
may be the	33
the cns that	33
of the cells	33
t cells within	33
resulting in the	33
in glial cells	33
depend on the	33
derived neurotrophic factor	33
also can be	33
we have identified	33
the spread of	33
b cells and	33
but not the	33
been found in	33
distribution of the	33
of reactive astrocytes	33
to better understand	33
brains and spinal	33
is expressed by	33
retrospective study of	33
study is to	33
t cells during	33
the choroid plexus	33
was seen in	33
results of a	33
significant differences in	33
is essential to	33
the plasma membrane	33
our results indicate	33
component of the	33
of the cell	33
been demonstrated in	33
here we show	33
white matter lesions	33
subacute sclerosing panencephalitis	33
in white matter	33
is not a	33
memory b cells	32
cells specific for	32
a period of	32
of the hippocampus	32
for the diagnosis	32
for cd t	32
no significant difference	32
institute of technology	32
may be related	32
of ms and	32
are essential for	32
and cd b	32
hospitalized patients with	32
innate immune responses	32
first case of	32
may be useful	32
to be determined	32
with the exception	32
is likely to	32
results showed that	32
not associated with	32
expression levels of	32
may be important	32
virus infection and	32
for the study	32
red blood cell	32
autoimmune encephalomyelitis in	32
can occur in	32
in the other	32
is seen in	32
world health organization	32
of ctl escape	32
by cd t	32
inflammation and demyelination	32
the early stages	32
nerve growth factor	32
to be an	32
based on clinical	32
an attempt to	32
more than one	32
data demonstrate that	32
we hypothesize that	32
encephalitis in mice	32
the results suggest	32
in comparison with	32
of novel coronavirus	32
significant decrease in	32
lymphoma in cats	32
or absence of	32
po q h	32
cd b ly	32
presence or absence	32
effect of the	32
the development and	32
such as il	32
in the majority	32
led to a	32
be present in	32
as a consequence	32
as described previously	32
learning and memory	32
from the central	32
induction of the	31
and response to	31
wang et al	31
o u r	31
of viral encephalitis	31
was diagnosed with	31
indicating that the	31
focal cerebral ischemia	31
its role in	31
the first case	31
significant difference in	31
we present a	31
induced by a	31
at time of	31
cytotoxic t cell	31
have been demonstrated	31
which leads to	31
before and after	31
studies on the	31
been reported that	31
inflammation in the	31
patients with acute	31
in the pathophysiology	31
are more likely	31
key role in	31
sod g a	31
and did not	31
responses to the	31
the disease process	31
absence of cd	31
important for the	31
that may be	31
each of these	31
brain barrier and	31
we found a	31
is not clear	31
may be an	31
patients with the	31
neurons and astrocytes	31
c bl j	31
the brain is	31
rat spinal cord	31
associated with severe	31
are critical for	31
can be found	31
in mice with	31
been identified as	31
and white matter	31
the s protein	31
did not have	31
vesicular stomatitis virus	31
a median of	31
of action of	31
the basal ganglia	31
of demyelination in	31
a reduction of	31
binding to the	31
be useful in	31
be treated with	31
infection in mice	31
result in a	31
major role in	31
class ii expression	31
the most commonly	31
the start of	31
and development of	31
we will discuss	31
were used for	31
expression of il	31
oligodendrocyte precursor cells	31
obtained from the	31
and there is	31
the respiratory tract	31
systematic review and	30
the kinetics of	30
studies are needed	30
standard of care	30
in central nervous	30
there is also	30
of viral infection	30
the notion that	30
cytokines in the	30
within the first	30
of the underlying	30
in mice lacking	30
at least in	30
of demyelination and	30
cells in multiple	30
was also observed	30
p r o	30
focused on the	30
lead to a	30
t cells is	30
the proliferation of	30
leading cause of	30
potential role of	30
neuronal cell death	30
transgenic mice were	30
if the patient	30
of the respiratory	30
in the primary	30
as a model	30
their role in	30
in the process	30
added to the	30
blood mononuclear cells	30
intensive care unit	30
common cause of	30
be helpful in	30
that cd t	30
patients with chronic	30
could contribute to	30
injury to the	30
an increase of	30
from the periphery	30
upper respiratory tract	30
of the primary	30
p r e	30
and endothelial cells	30
as measured by	30
in the anterior	30
shown to have	30
and t cells	30
consistent with a	30
the quality of	30
of neurons and	30
at this time	30
in cd t	30
a protective role	30
peripheral blood mononuclear	30
the hpa axis	30
in c bl	30
in peripheral blood	30
in the substantia	30
the clearance of	30
syndrome associated with	30
we suggest that	30
multiple sclerosis in	30
mechanism by which	30
an in vitro	30
the ratio of	30
transgenic mice with	30
to that in	30
that these cells	30
due to its	30
the exception of	30
clinical signs associated	30
of coronavirus disease	30
virus replication in	30
of the p	30
regardless of the	30
all patients were	30
t cells with	30
microglia and macrophages	30
in these cases	30
viral infections in	30
in those with	30
this study we	30
and central nervous	30
were analyzed using	30
we are currently	30
layer of the	30
and demyelination in	29
mhv infection of	29
treatment consists of	29
was no significant	29
of type i	29
of expression of	29
as a marker	29
the location of	29
in all cases	29
previously shown that	29
during wnv infection	29
a l p	29
accumulation in the	29
of a single	29
onset of disease	29
we also found	29
class ii molecules	29
molecules such as	29
to the presence	29
the amplitude of	29
altered mental status	29
a central role	29
the maintenance of	29
cells such as	29
clinical signs are	29
and the cns	29
this work was	29
r n a	29
molecular mechanisms of	29
that there are	29
under the control	29
parts of the	29
to a lesser	29
evidence for a	29
and differentiation of	29
present study was	29
u r n	29
inflammatory cytokines and	29
to respond to	29
in the second	29
cns infiltration of	29
were determined by	29
play a critical	29
and to the	29
alterations in the	29
unique teaching points	29
the length of	29
to the pathogenesis	29
was shown that	29
is also a	29
it has also	29
of viral antigen	29
of the sars	29
strain of mouse	29
of gene expression	29
been identified in	29
n a l	29
have been proposed	29
and dendritic cells	29
has shown that	29
the virus to	29
is accompanied by	29
in all patients	29
from multiple sclerosis	29
chart review of	29
on the cell	29
been demonstrated to	29
stages of the	29
gfapcr d mice	29
with clinical signs	29
is crucial for	29
of human coronavirus	29
severity of the	29
identification of the	29
leading to the	29
nk cells in	29
of chemokine receptors	29
the host cell	29
have been observed	29
cxcl and cxcl	29
endothelial cells and	29
at days and	29
of nipah virus	29
t cells into	29
for a minimum	29
r o o	29
to address this	29
the differential diagnosis	29
early in the	29
in an attempt	29
cells to the	29
were used as	29
of the initial	29
to the spinal	29
the evolution of	29
of murine coronavirus	29
part of a	29
after the onset	29
o o f	29
j o u	29
not detected in	29
l p r	29
in the current	29
gaba a receptors	28
of the peripheral	28
time course of	28
but did not	28
result in the	28
can be observed	28
able to induce	28
we demonstrated that	28
demonstrate that the	28
patients had a	28
also observed in	28
and cerebrospinal fluid	28
t cells can	28
an inflammatory response	28
out of the	28
and do not	28
small number of	28
even in the	28
when compared with	28
histocompatibility complex class	28
number of cd	28
cell adhesion molecules	28
during the early	28
we report that	28
cc chemokine receptor	28
here we report	28
of macrophages and	28
our results show	28
vivo and in	28
review and meta	28
insights into the	28
is necessary to	28
were isolated from	28
by in situ	28
the cd t	28
to occur in	28
in line with	28
relationship between the	28
central and peripheral	28
expression of ifn	28
could be detected	28
most of these	28
with the presence	28
that could be	28
due to an	28
is a critical	28
and nk cells	28
followed by administration	28
cells that are	28
japan we have	28
correlates with the	28
is a key	28
infection in a	28
of at least	28
that the virus	28
cells may be	28
in human brain	28
and management of	28
often associated with	28
have previously shown	28
of which are	28
system in the	28
important in the	28
we have recently	28
linked to the	28
to have an	28
in ms and	28
the entry of	28
result of the	28
from the blood	28
sr t cell	28
to characterize the	28
in the pns	28
chemokines and their	28
of chemokines in	28
the virus is	28
the spinal cords	28
infected with the	28
the peak of	28
is not well	28
of major histocompatibility	28
an immune response	28
a persistent infection	28
produced by the	28
have reported that	28
not been reported	28
which in turn	28
it should be	28
mice transgenic for	28
a significant decrease	28
and the other	28
in spinal cords	28
mrna expression in	28
innate immune system	28
area of the	28
infected mice were	28
did not alter	27
fresh frozen plasma	27
was induced by	27
in brains of	27
in regulation of	27
this may be	27
which is the	27
months to years	27
age at diagnosis	27
to explore the	27
at the onset	27
we have developed	27
been demonstrated that	27
pediatric oncology patients	27
important role for	27
administration of activated	27
may be used	27
murine model of	27
any of the	27
a part of	27
patients infected with	27
in which a	27
in the last	27
were diagnosed with	27
death in the	27
of more than	27
increased the number	27
the adaptive immune	27
and of the	27
side of the	27
japan in the	27
is similar to	27
cell proliferation and	27
the presence or	27
was expressed in	27
tip of the	27
complete blood count	27
enter the brain	27
cells were washed	27
antigen in the	27
acute phase of	27
is capable of	27
systemic lupus erythematosus	27
amyloid precursor protein	27
this type of	27
in rat brain	27
not only in	27
mild to moderate	27
possible role of	27
riken brain science	27
what is the	27
coronavirus in the	27
mice with a	27
we have found	27
it is known	27
the cns following	27
retrospective review of	27
were included in	27
response to infection	27
the finding that	27
reported that the	27
in a number	27
of cns inflammation	27
is the major	27
expression of these	27
viral clearance from	27
reduction of the	27
in this case	27
and the patient	27
we studied the	27
pathogenesis of the	27
identified as a	27
the inflamed cns	27
as described above	27
play important roles	27
in the bone	27
and review of	27
each of the	27
of disease and	27
the ca region	27
cells in a	27
in ms is	27
cases in which	27
in the activation	27
aspect of the	27
of a large	27
results suggested that	27
in the striatum	27
adaptive immune response	27
of hospitalized patients	27
analysis revealed that	27
fibroblast growth factor	27
studies have demonstrated	27
the tip of	27
the hippocampus of	26
response to viral	26
role for cd	26
syncytial virus infection	26
the anterior chamber	26
the secretion of	26
g a mice	26
the clinical course	26
the interaction between	26
cytotoxic t lymphocyte	26
virus infections in	26
the cns has	26
antigen presenting cells	26
a child with	26
injected into the	26
of cytokines in	26
cells can be	26
recruited to the	26
response to treatment	26
to be expressed	26
has recently been	26
models of ms	26
multiple sclerosis brain	26
areas of demyelination	26
animal model for	26
for viral clearance	26
in these cells	26
the functions of	26
we have demonstrated	26
cleared from the	26
a report of	26
it appears that	26
of this disease	26
was defined as	26
the vagus nerve	26
neurological manifestations of	26
studies showed that	26
migrate to the	26
form of the	26
the patient and	26
significant reduction in	26
is observed in	26
after the first	26
these data indicate	26
is well known	26
the volume of	26
on the cns	26
formation of the	26
national institute for	26
the clinical and	26
in mice and	26
sjl j mice	26
of the genes	26
in a significant	26
the gray matter	26
that the expression	26
simplex virus type	26
to patients with	26
has been implicated	26
several studies have	26
are not well	26
if there is	26
human coronavirus e	26
higher levels of	26
it is clear	26
to contribute to	26
an essential role	26
fold increase in	26
ability of the	26
t cells specific	26
is controlled by	26
to prevent further	26
invasion of the	26
in host defense	26
to days after	26
better understanding of	26
in approximately of	26
or spinal cord	26
the animal is	26
increase the risk	26
neuronal death in	26
our data suggest	26
was identified in	26
and peripheral nervous	26
of the injury	26
presented with a	26
also found that	26
previous studies have	26
investigated the effect	26
these findings indicate	26
clinical and pathological	26
patients with hlh	26
the goal of	26
treatment of the	26
determined by the	26
not significantly different	26
a significant reduction	26
no significant differences	26
in the brainstem	26
the action of	26
during the acute	26
of the affected	26
leads to the	26
of a new	26
majority of the	26
patients who received	26
the frequency and	26
a role of	26
t cell subsets	26
was significantly higher	26
by human coronavirus	26
patients who had	26
we report the	26
is a potent	26
with the development	26
mice lacking the	26
associated with ms	26
department of anatomy	26
at least three	26
class i molecules	26
belongs to the	25
to rule out	25
a marker of	25
which results in	25
of the three	25
was similar to	25
a marker for	25
the spleen and	25
made based on	25
results of the	25
of a neurotropic	25
system of the	25
patients with sickle	25
around the world	25
and is a	25
can cause a	25
to the virus	25
number of patients	25
cellular and molecular	25
previously reported that	25
over the course	25
evidence indicates that	25
of which were	25
identified in the	25
p and p	25
neuronal activity in	25
intravenous fluids to	25
the adult brain	25
in two cats	25
the total number	25
no difference in	25
of pediatric patients	25
critical role of	25
the authors declare	25
in mgfapcre ifnar	25
associated with covid	25
in vitro studies	25
there is evidence	25
to test the	25
both cd and	25
role for the	25
in the s	25
important to note	25
invade the cns	25
ccl in the	25
of rats with	25
hev and niv	25
although it is	25
not able to	25
astrocytes and oligodendrocytes	25
cell death and	25
nodes of ranvier	25
we demonstrate that	25
in the cell	25
the brain in	25
localization of the	25
an average of	25
comparison of the	25
and the development	25
th cells in	25
cerebral blood flow	25
of the infection	25
one of these	25
of microglial cells	25
described in the	25
and class ii	25
among patients with	25
the cns at	25
in the injured	25
intravenous crystalloid fluids	25
primary and secondary	25
nile virus encephalitis	25
in of cases	25
we examined whether	25
in neurons and	25
examined the effect	25
cells as well	25
have been detected	25
not well understood	25
oligodendrocyte progenitor cells	25
is known that	25
a monoclonal antibody	25
were seen in	25
and progression of	25
in the elderly	25
of the present	25
it is well	25
of the body	25
well as a	25
account for the	25
in the acute	25
dorsal root ganglia	25
of cd and	25
to define the	25
were performed in	25
disease in mice	25
index of suspicion	24
of the cellular	24
compared to that	24
could be involved	24
naive t cells	24
of virus replication	24
the mouse brain	24
liu et al	24
leukemia in a	24
attributed to the	24
the changes in	24
the patient with	24
sars and mers	24
protective effect of	24
mice in which	24
gain access to	24
majority of cases	24
models of multiple	24
encephalitis associated with	24
was higher in	24
patient with a	24
impact on the	24
rat model of	24
studies of the	24
insight into the	24
investigated the effects	24
is in the	24
of the main	24
various types of	24
and is not	24
directly into the	24
might be involved	24
well as to	24
in the visual	24
was used as	24
have to be	24
we aimed to	24
in the management	24
of acute and	24
has led to	24
to the control	24
was to evaluate	24
which have been	24
cns through the	24
the response to	24
syndrome coronavirus infection	24
in an animal	24
of neural stem	24
disease progression in	24
after the initial	24
we developed a	24
of inflammation in	24
the prefrontal cortex	24
genes in the	24
in these mice	24
activated microglia and	24
programmed cell death	24
to improve the	24
confined to the	24
as an important	24
of purkinje cells	24
not required for	24
to those of	24
demyelinating disease in	24
be observed in	24
that the presence	24
microglial cells in	24
factor in the	24
neural progenitor cells	24
of class i	24
manifestations of covid	24
g hi granulocytes	24
further studies are	24
clinical signs and	24
of these molecules	24
that it is	24
a median age	24
significantly associated with	24
of developing ms	24
an increased risk	24
of transgenic mice	24
nervous system is	24
in one cat	24
to induce a	24
and induction of	24
viral replication and	24
have suggested that	24
in these animals	24
to reach the	24
with a history	24
during jhmv infection	24
of the glial	24
transgenic mice expressing	24
in neurodegenerative diseases	24
is defined as	24
sclerosis multiple sclerosis	24
the median age	24
we evaluated the	24
t lymphocytes in	24
cerebral artery occlusion	24
olfactory sensory neurons	24
and the role	24
in the lungs	24
viral infection in	24
used to determine	24
the cns as	24
applied to the	24
to wt mice	24
at risk for	24
is a member	24
of this review	24
studies have been	24
gene expression and	24
well as their	24
administration of a	24
multiple sclerosis multiple	24
and astrocytes in	24
the observation that	24
other types of	24
m and m	24
a significant role	24
transgenic mouse model	24
evidence of the	24
infectious virus is	24
class i mhc	24
progression of the	24
are similar to	24
was identified as	24
analysis showed that	24
the skin and	24
cats with lymphoma	24
in mice transgenic	24
these cells were	24
in lewis rats	24
t cells isolated	24
as one of	24
is not required	24
acute chest syndrome	24
patients who were	24
we have examined	24
were incubated with	24
and should be	24
in a recent	24
inflammatory demyelinating disease	24
of ccl in	24
not in the	24
myelination in the	24
infection of human	24
gene expression of	24
in the frontal	24
has to be	24
in at least	24
report of a	24
is expressed on	23
functions in the	23
demyelination and axonal	23
spinal cord compression	23
in one study	23
old male with	23
cervical lymph nodes	23
feline immunodeficiency virus	23
during the study	23
in the immune	23
it is thought	23
will be presented	23
mrna and protein	23
of both the	23
h after the	23
status of the	23
the most severe	23
in the cytoplasm	23
portions of the	23
would like to	23
was no difference	23
was increased in	23
indicated that the	23
in the clinical	23
with severe acute	23
in the respiratory	23
in a single	23
in individuals with	23
localized to the	23
we sought to	23
be induced by	23
we observed that	23
the cns was	23
diagnosis and treatment	23
a transgenic mouse	23
cxcr and cxcr	23
the patient has	23
magnitude of the	23
the selection of	23
disseminated intravascular coagulation	23
has the potential	23
specific cytotoxic t	23
in the inflamed	23
these results demonstrate	23
western blot analysis	23
appeared to be	23
nk cells and	23
basic protein in	23
infected with mhv	23
modulation of the	23
reactive astrocytes in	23
of ms in	23
in viral encephalitis	23
as evidenced by	23
fluids to maintain	23
conflict of interest	23
is followed by	23
lavi et al	23
of the role	23
increased risk for	23
in bone marrow	23
the cns can	23
the cells were	23
immune system in	23
as shown in	23
the potential of	23
administer intravenous fluids	23
has been detected	23
an inhibitor of	23
as compared with	23
infection and the	23
of inducible nitric	23
compared to wt	23
age of years	23
phares et al	23
bl mice were	23
were divided into	23
in this population	23
nervous system disease	23
observations suggest that	23
was performed to	23
major cause of	23
hi monocytes and	23
critical for the	23
is composed of	23
humoral immune response	23
is considered to	23
of cytokines and	23
significantly increased in	23
was carried out	23
be one of	23
of the head	23
the virus can	23
in the optic	23
plays a critical	23
the underlying cause	23
we report a	23
associated with acute	23
were identified in	23
a population of	23
not affect the	23
in t cell	23
throughout the cns	23
the possible role	23
is a well	23
of clinical disease	23
diagnostic criteria for	23
the clinical signs	23
viral load in	23
in cats and	23
be explained by	23
data show that	23
to ml kg	23
may be considered	23
for the detection	23
multiple sclerosis a	22
of measles virus	22
be induced in	22
these data demonstrate	22
results from the	22
it is the	22
of the animal	22
in the future	22
the cns may	22
cells were not	22
of inflammation and	22
differential expression of	22
as multiple sclerosis	22
functional role of	22
of the gene	22
of a viral	22
primary cultures of	22
that activation of	22
to investigate whether	22
particularly in the	22
used to treat	22
cd hi cd	22
immune response and	22
in the murine	22
with a mean	22
factors in the	22
those in the	22
a virus infection	22
its ability to	22
proven to be	22
different brain regions	22
the balance between	22
the blood and	22
the area of	22
to our knowledge	22
this is not	22
compared to wild	22
in brain tissue	22
the current study	22
a bone marrow	22
shown in fig	22
the infiltration of	22
is independent of	22
levels of cd	22
care and use	22
a source of	22
most common cause	22
more frequent in	22
mechanism for the	22
we compared the	22
marked increase in	22
the sciatic nerve	22
the gene expression	22
can be treated	22
with monoclonal antibodies	22
observed in patients	22
correlation between the	22
the pathology of	22
a higher risk	22
infection with the	22
mice with the	22
the mechanisms underlying	22
persistent infection of	22
to suggest that	22
are required to	22
is correlated with	22
congestive heart failure	22
spinal cord tissue	22
can also occur	22
absence of a	22
in expression of	22
was noted in	22
nipah virus infection	22
institutes of health	22
a novel coronavirus	22
study of cases	22
the developing brain	22
li et al	22
expression in astrocytes	22
memory t cell	22
total of patients	22
they can be	22
cells with a	22
damage in the	22
the infection of	22
patients with cns	22
in immunocompromised patients	22
gaba a receptor	22
are important for	22
cells are the	22
induction of experimental	22
of virus in	22
this effect was	22
the mechanisms by	22
through the olfactory	22
in the ventral	22
chemokine expression in	22
i and ii	22
are resistant to	22
the general population	22
is used to	22
these results suggested	22
been documented in	22
study showed that	22
sensitivity and specificity	22
t cell infiltration	22
protein in the	22
the inability of	22
was a significant	22
a rat model	22
removal of the	22
ml kg hour	22
is found in	22
has not yet	22
clearance from the	22
will discuss the	22
were reported in	22
over the past	22