bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
nervous system	1627
multiple sclerosis	1491
central nervous	1246
spinal cord	1205
virus infection	561
clinical signs	545
immune response	517
mg kg	514
bone marrow	485
white matter	451
transgenic mice	402
results suggest	394
gene expression	367
brain barrier	347
class i	337
demyelinating disease	335
viral infection	333
immune responses	329
glial cells	327
ms patients	321
cerebrospinal fluid	319
design method	318
infected mice	317
mhc class	316
experimental autoimmune	316
hepatitis virus	307
autoimmune encephalomyelitis	304
immune system	276
viral infections	272
mouse hepatitis	270
research funds	268
nitric oxide	263
united states	261
cell death	260
class ii	257
present study	256
cell responses	254
nk cells	246
endothelial cells	240
respiratory syndrome	235
west nile	232
acute respiratory	230
basic protein	228
immune cells	218
inflammatory response	218
myelin basic	218
growth factor	214
nile virus	210
type i	209
specific cd	208
animal models	207
important role	204
cell types	197
borna disease	196
stem cell	193
schwann cells	192
may also	190
microglial cells	189
peripheral blood	188
spinal cords	184
th cells	183
cell lines	182
inflammatory cytokines	181
chemokine receptor	176
graduate school	174
mice infected	173
innate immune	172
chemokine receptors	171
viral replication	170
infected cells	169
severe acute	167
results indicate	164
deficient mice	164
necrosis factor	162
pediatric patients	161
mouse model	160
dendritic cells	159
risk factors	158
lymph nodes	157
human coronavirus	156
cord injury	154
progenitor cells	153
reactive astrocytes	149
states background	148
tumor necrosis	148
olfactory bulb	147
cell response	146
brain injury	146
induced demyelination	145
viral encephalitis	142
stem cells	141
viral rna	141
optic nerve	140
experimental allergic	139
magnetic resonance	138
data suggest	137
cell proliferation	137
disease virus	137
ko mice	137
infectious virus	136
doc id	136
cord uid	136
allergic encephalomyelitis	135
activated microglia	135
cell surface	134
kg iv	131
measles virus	130
herpes simplex	130
virus replication	130
cd foxp	129
jhmv infection	127
cerebral cortex	126
bl mice	126
inflammatory cells	125
cell line	124
myeloid cells	124
adaptive immune	123
syndrome coronavirus	122
coronavirus infection	122
rat brain	121
recent studies	121
molecular mimicry	120
brain tissue	120
respiratory tract	119
mrna expression	118
influenza virus	118
respiratory distress	117
side effects	117
autoimmune disease	116
positive cells	116
amino acid	115
coronavirus disease	114
may play	114
flow cytometry	114
cns infection	114
may contribute	112
brain stem	112
animal model	111
neurological symptoms	111
mononuclear cells	110
wt mice	110
novel coronavirus	110
disease progression	109
brain regions	109
monoclonal antibodies	109
cx cr	109
oxide synthase	108
median age	107
neurological manifestations	107
virus infections	107
following infection	106
clinical trials	106
ml kg	106
neuronal activity	106
monoclonal antibody	106
persistent infection	106
neurodegenerative diseases	105
high levels	105
major histocompatibility	104
murine coronavirus	104
nipah virus	104
cell activation	104
cells may	103
mean age	103
mouse brain	103
blood pressure	103
viral clearance	103
tcr transgenic	103
sickle cell	103
findings suggest	102
human brain	102
resonance imaging	102
one patient	101
significantly increased	101
cns inflammation	100
viral antigen	99
pulmonary edema	99
ms lesions	98
previous studies	98
encephalomyelitis virus	98
microglial activation	98
host defense	98
immunodeficiency virus	97
wnv infection	97
determine whether	97
cell type	96
cell adhesion	96
cells within	96
proinflammatory cytokines	94
cns disease	94
ex vivo	94
oxidative stress	93
induced demyelinating	93
cd th	93
infectious diseases	92
cell receptor	92
molecular mechanisms	92
critical role	92
neurotropic viruses	92
murine encephalomyelitis	91
neurotropic coronavirus	91
simplex virus	91
cns cells	91
mhv infection	91
wild type	90
may occur	90
feline infectious	89
transcription factor	89
increased risk	89
control mice	89
adoptive transfer	89
nk cell	89
amino acids	88
infectious peritonitis	88
significantly higher	88
glial cell	88
hippocampal neurons	88
neurological disease	87
retrospective study	87
gray matter	87
neuronal death	87
neutralizing antibodies	87
peripheral nervous	87
je progression	87
antigen presentation	87
inflammatory responses	86
histocompatibility complex	86
one cat	86
clinical disease	86
cell transplantation	86
tissue damage	86
mice showed	86
foxp tregs	86
situ hybridization	85
blood cell	85
knockout mice	85
cytokine storm	85
also found	85
case series	84
days post	84
weight loss	84
neural stem	84
respiratory syncytial	83
physical examination	82
natural killer	82
adhesion molecule	82
japanese encephalitis	82
mg dl	82
disease severity	82
growth factors	81
acute infection	81
significantly reduced	81
myelin sheath	81
body weight	81
activated charcoal	81
orogastric lavage	80
purkinje cells	80
cns involvement	80
cell migration	80
cell disease	80
neurological signs	80
adhesion molecules	79
cell clones	79
may result	79
previously described	79
viral load	79
case report	79
taken together	79
fl fl	79
brain parenchyma	78
cell infiltration	78
mice lacking	78
significant increase	78
sclerosis patients	78
epithelial cells	78
lymphocytic choriomeningitis	78
stimulating factor	78
middle east	78
virus type	78
syncytial virus	78
synaptic plasticity	78
cell populations	77
clinical symptoms	77
significant differences	77
optic neuritis	77
cortical neurons	77
cerebral ischemia	76
neurological diseases	76
respiratory failure	76
blood vessels	76
axonal transport	76
encephalitis virus	76
respiratory viruses	75
autoimmune diseases	75
hi monocytes	75
mrna levels	75
neurological disorders	75
rna viruses	75
statistically significant	75
lymph node	75
cell population	74
national institute	74
synaptic transmission	74
type mice	74
systematic review	74
neuronal cell	74
choroid plexus	74
mechanisms underlying	74
kg po	74
renal failure	73
peripheral nerve	73
mbp tcr	73
hematopoietic stem	73
clinical features	73
electron microscopy	73
blood flow	73
treated mice	72
low levels	72
east respiratory	72
cells expressing	72
corpus callosum	71
two patients	71
cells isolated	71
transcription factors	71
prefrontal cortex	71
neurological complications	71
kg day	71
previously reported	71
substantia nigra	71
cytokine production	71
barr virus	71
schwann cell	70
years old	70
virus encephalitis	70
time points	69
cell subsets	69
progressive ms	69
protein kinase	69
disease process	69
precursor cells	69
soft tissue	69
red blood	69
ctl escape	68
viral persistence	68
two cats	68
chart review	68
human immunodeficiency	68
intravenous fluids	67
basal ganglia	67
coronavirus oc	67
acute encephalitis	67
motor neurons	67
receptor antagonist	67
ifnar fl	67
pediatric oncology	67
environmental factors	67
also observed	67
neurotrophic factor	67
clinical characteristics	66
neuronal damage	66
neuronal cells	66
cd cells	66
patients received	66
matrix metalloproteinase	66
gastrointestinal tract	66
human coronaviruses	66
mouse models	66
cns infections	66
increased expression	65
highly expressed	65
research institute	65
case reports	65
glial fibrillary	65
cd cd	65
expression levels	65
neural cells	64
choriomeningitis virus	64
cell count	64
demyelinating lesions	64
microglia activation	64
per cent	64
also known	64
may lead	64
brain science	64
acidic protein	64
viral antigens	64
severe disease	64
innate immunity	64
presenting cells	64
platelet count	63
protein expression	63
see section	63
rlcmv indg	63
performed using	63
memory cd	63
western blot	63
significant difference	63
nmda receptor	63
acute phase	63
dentate gyrus	63
microglia macrophages	63
least one	62
visual cortex	62
cell lymphoma	62
high risk	62
risk factor	62
demyelinating diseases	62
old male	61
protein concentration	61
differential diagnosis	61
fibrillary acidic	61
i interferon	61
plasma membrane	61
transgenic mouse	61
amyotrophic lateral	61
target cells	61
blood brain	61
ng ml	61
clinical trial	61
computed tomography	61
rabies virus	61
sjl mice	60
retrospective chart	60
cns infiltration	60
data indicate	60
axonal damage	60
remains unclear	60
analysis revealed	60
lateral sclerosis	60
long term	60
abdominal pain	59
results show	59
grey matter	59
dependent manner	59
several studies	59
supplemental oxygen	59
polymerase chain	58
adult mice	58
chain reaction	58
immune cell	58
mediated demyelination	58
clinical course	58
lineage cells	58
dorsal root	57
host cell	57
marrow transplantation	57
myelin sheaths	57
motor neuron	57
resident microglia	57
hendra virus	57
may provide	57
binding protein	57
rl mice	57
cell apoptosis	57
pleural effusion	57
may cause	57
lewis rats	57
sclerosis lesions	57
poorly understood	57
viral proteins	56
neuropathic pain	56
blood cells	56
converting enzyme	56
flow cytometric	56
chemoattractant protein	56
monocyte chemoattractant	56
infected animals	56
tumor cells	56
signal transduction	56
cell cultures	56
significantly decreased	55
heart rate	55
olfactory epithelium	55
myelin antigens	55
fl mice	55
even though	55
signaling pathway	55
lymphoblastic leukemia	55
high dose	55
recent study	55
large number	54
spike protein	54
ischemic stroke	54
disease activity	54
mutant mice	54
monocytes macrophages	54
extracellular matrix	53
escape mutants	53
acute lymphoblastic	53
early stages	53
neural cell	53
studies suggest	53
ng cells	53
hemophagocytic lymphohistiocytosis	53
time course	53
inducible nitric	53
transforming growth	53
disseminated encephalomyelitis	53
sensory neurons	53
pyramidal neurons	53
viral encephalomyelitis	53
progressive multiple	53
three patients	53
epitope spreading	53
resident cells	53
forest virus	52
inflammatory demyelinating	52
patients treated	52
nerve injury	52
neutralizing antibody	52
traumatic brain	52
young adults	52
semliki forest	52
sciatic nerve	51
reactive oxygen	51
infected patients	51
infectious agents	51
protective role	51
disease course	51
days later	51
key role	51
specific antibodies	51
well known	51
proteolipid protein	50
patients receiving	50
cellular immune	50
neurologic disease	50
osaka univ	50
evidence suggests	50
ccr mice	50
host immune	50
viral spread	50
pediatric population	50
hippocampal slices	50
chronic demyelination	50
mice compared	50
matrix metalloproteinases	50
human respiratory	50
ca region	49
cd expression	49
jev infection	49
ependymal cells	49
pediatr radiol	49
mr imaging	49
persistently infected	49
infiltrating macrophages	49
white blood	49
mice exhibited	49
studies using	49
lower respiratory	49
myelin protein	49
brain function	49
effector function	49
overall survival	49
old female	49
brain tumors	49
pd patients	48
cns disorders	48
systemic inflammation	48
myelin proteins	48
commonly used	48
crucial role	48
positron emission	48
pet ct	48
rheumatoid arthritis	48
granule cells	48
neurite outgrowth	48
functional recovery	48
effector cells	48
acute disseminated	48
cc chemokine	48
cns tissue	48
brain development	48
important roles	47
remitting multiple	47
opc differentiation	47
specific ctl	47
prospective study	47
university graduate	47
progressive multifocal	47
results demonstrate	47
induce emesis	47
cns viral	47
urinary tract	47
clinical presentation	47
acute viral	47
mechanical ventilation	47
plasma cells	47
diagnostic criteria	47
brain lesions	47
two groups	47
childhood cancer	47
cd hi	47
inflammatory monocytes	47
university school	47
medical center	47
signaling pathways	47
tg mice	46
kyoto university	46
infected neurons	46
jhm virus	46
significantly lower	46
oligodendrocyte glycoprotein	46
patients may	46
mice deficient	46
mice treated	46
whole blood	46
ablated mice	46
adult brain	46
cns parenchyma	46
cell function	46
cns resident	46
ccr cd	46
viral burden	46
chronic demyelinating	46
myelin oligodendrocyte	46
severe cases	46
significantly different	45
chronic progressive	45
normal mice	45
will discuss	45
two different	45
first case	45
ct scan	45
previously shown	45
respiratory depression	45
vast majority	45
mgfapcre ifnar	45
relapse rate	45
ctl response	45
i ifn	45
macrophage infiltration	45
cells ml	45
within days	45
days postinfection	44
new york	44
csf samples	44
one study	44
inflammatory cytokine	44
analyzed using	44
may help	44
pyramidal cells	44
inflammatory disease	44
multifocal leukoencephalopathy	44
nmda receptors	44
membrane potential	44
three cats	44
another study	44
perform orogastric	44
infection may	44
multiple myeloma	44
viral particles	44
four patients	44
dopaminergic neurons	44
disease onset	43
post mortem	43
mental status	43
rna virus	43
humoral immunity	43
head trauma	43
murine hepatitis	43
cell bodies	43
demyelination induced	43
tyrosine kinase	43
chemokine expression	43
cell culture	43
give rise	43
inflammatory diseases	43
protein levels	43
killer cells	43
intranasal inoculation	42
like receptors	42
inflammatory protein	42
two distinct	42
gamma interferon	42
derived cells	42
mononuclear cell	42
clinical practice	42
increased levels	42
public health	42
dengue virus	42
zika virus	42
inflammatory cell	42
myasthenia gravis	42
antibody response	42
coronavirus infections	42
viral control	42
morphological changes	42
may reflect	42
csf protein	42
administer intravenous	42
peripheral nerves	42
cns demyelination	42
brain cells	42
imaging findings	42
receptor binding	42
oncology patients	42
studies indicate	41
upper respiratory	41
limb paralysis	41
emission tomography	41
science institute	41
analysis showed	41
increased mortality	41
intensive care	41
murine model	41
neuronal injury	41
different types	41
rat spinal	41
peripheral immune	41
study group	41
fluid therapy	41
virus clearance	41
binding sites	41
rat model	41
oligodendrocyte precursor	41
ido ko	41
cell cycle	41
specific antibody	41
axonal injury	41
macrophage inflammatory	41
high frequency	41
results showed	41
cognitive impairment	41
study showed	41
also occur	41
secondary progressive	41
adult rats	41
glial activation	41
stranded rna	41
viral titers	41
inflammatory mediators	41
possible role	41
naturally occurring	41
may represent	41
controlled trial	40
receptor expression	40
crystalloid fluids	40
central role	40
cns diseases	40
fatty acids	40
total number	40
low dose	40
multiple organ	40
whenever possible	40
tissue injury	40
year old	40
findings indicate	40
chronic inflammatory	40
olfactory nerve	40
i expression	40
distress syndrome	40
higher levels	40
wide range	40
brain mri	40
antibody responses	40
potential role	40
described previously	40
inflammatory reaction	40
jhm infection	40
cell transplant	40
newly diagnosed	40
gnrh neurons	40
vaccinia virus	40
factor viii	40
neuronal loss	40
immune surveillance	39
axonal degeneration	39
fdg uptake	39
apoptotic cells	39
rat hippocampal	39
neurologic manifestations	39
cerebral artery	39
receptor ccr	39
incubation period	39
widely used	39
within hours	39
psychiatric disorders	39
metabolic acidosis	39
elevated protein	39
matter lesions	39
tmev infection	39
lethal infection	39
major role	39
many patients	39
focal cerebral	39
data demonstrate	39
dth response	39
clinical score	39
cns injury	39
cns via	39
cns pathology	38
mm hg	38
cellular immunity	38
adult cns	38
kg hour	38
mice expressing	38
oxygen species	38
antigen expression	38
may include	38
four cats	38
elevated levels	38
microglial cell	38
foreign bodies	38
plasma cell	38
protective effect	38
cytometric analysis	38
immune activation	38
infection induces	38
pet imaging	38
respiratory infections	38
immunocompromised patients	38
mediated immune	38
protein gene	38
therapeutic strategies	38
severe covid	37
coronavirus jhm	37
medical university	37
zoster virus	37
general anesthesia	37
significant decrease	37
glatiramer acetate	37
cerebral blood	37
kg minute	37
chronic pain	37
expression pattern	37
sars coronavirus	37
astrocyte activation	37
among patients	37
oligodendrocyte progenitor	37
hospitalized patients	37
high affinity	37
hemolytic anemia	37
hpa axis	37
experimental models	37
pilot study	37
subacute sclerosing	37
cells express	37
adult patients	37
myeloid leukemia	37
temporal lobe	37
single cell	37
immunohistochemical staining	36
cell differentiation	36
cxc chemokine	36
previous study	36
toxoplasma gondii	36
neurodegenerative disorders	36
acute disease	36
iron overload	36
ii expression	36
bipolar disorder	36
studies showed	36
myelin loss	36
many cases	36
control subjects	36
csf analysis	36
neurodegenerative disease	36
cells derived	36
healthy controls	36
infectious disease	36
patients without	36
mri findings	36
supportive care	36
cns lesions	36
molecular basis	36
room temperature	36
expression profiles	36
clinical manifestations	36
young adult	36
mediated immunity	36
pathological conditions	36
cell membrane	36
may require	35
hla class	35
five patients	35
family history	35
normal brain	35
cells specific	35
ca i	35
autoimmune response	35
cells also	35
expression patterns	35
cerebral edema	35
motor function	35
mature oligodendrocytes	35
type ii	35
pediatric hematology	35
time point	35
cytokine expression	35
bacterial infection	35
lewis rat	35
renal function	35
brain damage	35
bd biosciences	35
functional role	35
examined whether	35
middle cerebral	35
microglia may	35
expressing cells	35
remains unknown	35
young children	35
mhc molecules	35
mouse strains	35
potential therapeutic	35
staggering disease	35
osaka university	35
optic nerves	35
glutamate receptors	35
blood count	35
jhm strain	35
depleted mice	35
system infection	35
developing brain	35
radiation therapy	35
primary demyelination	35
hearing loss	35
surface expression	35
significant reduction	35
demyelinating encephalomyelitis	34
ctl responses	34
derived neurotrophic	34
virus strain	34
ii molecules	34
saline solution	34
family members	34
glutamate transporters	34
better understand	34
hippocampal ca	34
adaptive immunity	34
pediatric cancer	34
neurological deficits	34
endoplasmic reticulum	34
action potentials	34
adult mouse	34
acute myeloid	34
nerve growth	34
sendai virus	34
chronic infection	34
humoral immune	34
better understanding	34
pc cells	34
cns tissues	34
protein synthesis	34
cns myelin	34
heart failure	34
growth cone	34
cell recruitment	34
higher risk	34
central venous	34
nine patients	34
effector functions	34
yellow fever	34
myelin damage	34
infectious agent	34
wide variety	34
foreign body	34
cohort study	34
lymphoid tissue	34
intravenous crystalloid	33
clinical diagnosis	33
cell survival	33
immunohistochemical analysis	33
patients infected	33
data support	33
poor prognosis	33
like cells	33
fty treatment	33
sclerosing panencephalitis	33
complete blood	33
rubella virus	33
fold increase	33
cytokine release	33
leading cause	33
tspo expression	33
cns tumors	33
retrospective review	33
dendritic cell	33
human cns	33
world health	33
fatty acid	33
antigen presenting	33
chronic relapsing	33
neoplastic cells	33
statistical significance	33
mg ml	33
health care	33
data show	33
vascular malformations	33
clinical data	33
kyoto univ	33
postnatal day	33
post infection	33
flaccid paralysis	33
six patients	33
diabetes mellitus	33
intracranial inoculation	33
control group	33
bdv infection	33
disease caused	33
see chapter	33
microarray analysis	33
tissue destruction	33
demyelinated axons	33
axonal loss	33
adverse effects	33
may explain	33
solid tumors	33
day post	33
one case	33
glioma cells	33
vascular endothelial	33
pathogenic role	33
signs associated	33
vesicular stomatitis	33
glutamate receptor	33
i innate	33
two cases	33
many different	33
body temperature	32
tissue distribution	32
tract infections	32
statistical analysis	32
spinal fluid	32
well understood	32
virus may	32
respiratory system	32
specific immune	32
therapy may	32
altered mental	32
term potentiation	32
opioid receptors	32
gabaergic neurons	32
reported cases	32
cultured rat	32
tohoku univ	32
gold standard	32
inflamed cns	32
fluorescent protein	32
glutamate transporter	32
interferon gamma	32
myeloid cell	32
cd high	32
cell help	32
ischemic brain	32
time pcr	32
common cause	32
human herpesvirus	32
disease pathogenesis	32
adult rat	32
hiv infection	32
proinflammatory cytokine	32
precursor protein	32
secondary hlh	32
type astrocytes	32
health organization	32
early phase	32
viral entry	32
brain edema	32
neuronal differentiation	32
glutamate uptake	32
anterior chamber	32
macrophage colony	32
interferon beta	32
myelin components	32
genetic factors	32
macrophages microglia	32
hemorrhagic fever	32
predictive value	32
syndrome associated	32
virus entry	32
clinical studies	32
ad patients	32
alpha beta	32
activated macrophages	31
without affecting	31
slice cultures	31
intravenous immunoglobulin	31
fibroblast growth	31
nucleic acid	31
blood mononuclear	31
chronic disease	31
respiratory disease	31
arterial blood	31
also showed	31
nude mice	31
clinical outcomes	31
vagus nerve	31
expression level	31
activated astrocytes	31
following viral	31
cells via	31
cause severe	31
electron microscopic	31
results suggested	31
infected brain	31
stomatitis virus	31
ng glia	31
nucleated cell	31
underlying cause	31
care unit	31
frontal cortex	31
critically ill	31
mortality rate	31
muscle weakness	31
brain tissues	31
granule cell	31
sequence analysis	31
specific cytotoxic	31
induced encephalomyelitis	31
cell trafficking	31
sindbis virus	31
oligoclonal bands	31
human metapneumovirus	31
lupus erythematosus	30
gene products	30
small number	30
cell counts	30
differential expression	30
cancer survivors	30
immune function	30
essential role	30
different cell	30
san diego	30
persistent viral	30
patients developed	30
working memory	30
research center	30
see table	30
pg ml	30
cell entry	30
niv infection	30
i molecules	30
neuronal degeneration	30
total rna	30
human disease	30
serum albumin	30
astrocytes may	30
closely related	30
tokyo metropolitan	30
mechanisms involved	30
showed significant	30
blot analysis	30
year period	30
cervical lymph	30
similar results	30
thrombotic microangiopathy	30
direct viral	30
pathological changes	30
increased viral	30
evoked potentials	30
patients diagnosed	30
macrophage activation	30
pcr analysis	30
may induce	30
carbon dioxide	30
ev cases	30
projection neurons	30
therapeutic target	30
cerebrovascular disease	30
high doses	30
play important	30
tohoku university	30
may become	30
epidemiological studies	29
platelet counts	29
local anesthetic	29
lymphoid organs	29
canine distemper	29
intracellular calcium	29
less common	29
patients showed	29
imaging techniques	29
severe respiratory	29
new insights	29
spastic paraparesis	29
brain areas	29
viral pathogenesis	29
nerve conduction	29
neural activity	29
cardiac output	29
complex class	29
cell tumors	29
strain jhm	29
type iii	29
unclear whether	29
frozen plasma	29
basement membrane	29
like receptor	29
neuronal infection	29
also reported	29
patient population	29
urine output	29
adverse events	29
opioid receptor	29
increased susceptibility	29
susceptible mice	29
unique teaching	29
fresh frozen	29
receptor cxcr	29
ido ablation	29
mice transgenic	29
cell biology	29
teaching points	29
inflammatory processes	29
primary cultures	29
eye movement	29
treatment consists	29
effi cacy	29
structural proteins	29
case presentation	29
study using	29
antibody titers	29
lesions may	29
organ failure	28
medical school	28
pidd patients	28
systemic lupus	28
tight junctions	28
surgical resection	28
hi cd	28
renal disease	28
nerve terminals	28
patients undergoing	28
brain slices	28
neuronal function	28
often associated	28
existing asc	28
molecular mechanism	28
among children	28
ccl transgenic	28
intravenous catheter	28
jc virus	28
cns following	28
synapse formation	28
medical records	28
type hypersensitivity	28
nagoya university	28
transverse myelitis	28
artery occlusion	28
viral diseases	28
small animal	28
several days	28
steady state	28
lower levels	28
riken brain	28
intravenous fluid	28
cranial nerve	28
phase ii	28
may act	28
myelin debris	28
future studies	28
well documented	28
neuronal apoptosis	28
mortality rates	28
literature review	28
differential diagnoses	28
patient developed	28
gene encoding	28
blood cultures	28
significant role	28
pathogenic mechanisms	28
molecular weight	28
molecular biology	28
heart disease	28
induced neuronal	28
peripheral tissues	28
inflammatory demyelination	28
neural progenitor	28
saudi arabia	28
factor receptor	28
intracellular ca	28
control animals	28
hind limb	28
clinical improvement	28
disease may	28
beneficial effects	28
also present	28
informed consent	28
lymphoid cells	28
sterile saline	28
related genes	28
blood samples	27
results indicated	27
active ms	27
lyme disease	27
primary microglia	27
brain sections	27
induced cell	27
host cells	27
dna methylation	27
per year	27
cell body	27
inflammatory process	27
may affect	27
inducible protein	27
limbic system	27
th cytokines	27
also expressed	27
neurological involvement	27
skeletal muscle	27
emergency care	27
pediatric patient	27
neutrophilic pleocytosis	27
gap junction	27
ampa receptors	27
cx cl	27
infection causes	27
motor cortex	27
oc infection	27
dendritic spines	27
made based	27
cns inflammatory	27
first step	27
locomotor activity	27
receptive field	27
auditory cortex	27
dorsal horn	27
chemokine ligand	27
spike glycoprotein	27
investigated whether	27
reactive protein	27
infected rats	27
wistar rats	27
ctl activity	27
neuronal survival	27
amyloid precursor	27
age years	27
protective immunity	27
much higher	27
see also	27
developing ms	27
cord compression	27
complement activation	27
human ace	27
oligodendrocyte lineage	27
protein level	27
olfactory sensory	27
determined using	27
study demonstrated	27
high grade	27
neurotropic virus	27
tract infection	27
whole body	27
hodgkin lymphoma	27
microglia cells	26
antibiotic therapy	26
human neural	26
nontransgenic mice	26
monocyte differentiation	26
purkinje cell	26
intravascular coagulation	26
axonal regeneration	26
antibody production	26
mechanism underlying	26
one year	26
reactive gliosis	26
associated myelopathy	26
infiltrating cells	26
cell mediated	26
respiratory symptoms	26
chronic inflammation	26
cell infiltrates	26
least three	26
ms pathogenesis	26
investigate whether	26
well tolerated	26
medical management	26
mr images	26
disseminated intravascular	26
surface markers	26
cov infection	26
sclerosis brain	26
foxp gfp	26
early diagnosis	26
evidence indicates	26
tight junction	26
cardiac dysrhythmias	26
neuroinvasive potential	26
decision making	26
cns cell	26
underlying mechanisms	26
median time	26
studies demonstrate	26
smooth muscle	26
antiviral immune	26
status epilepticus	26
glial scar	26
definitive diagnosis	26
two weeks	26
thoracic radiographs	26
also important	26
low level	26
behavioral abnormalities	26
observations suggest	26
wnv encephalitis	26
alzheimer disease	26
cell memory	26
whole brain	26
following intranasal	26
endothelial cell	26
term neurological	26
gene transfer	26
cells following	26
head injury	26
total protein	26
inclusion criteria	26
may develop	26
cns may	25
vitro studies	25
pns myelin	25
cell epitopes	25
thyroid hormone	25
cell activity	25
root ganglia	25
virus specific	25
natural history	25
one hundred	25
authors declare	25
severe neurological	25
mice undergoing	25
age group	25
secreting cells	25
cognitive function	25
veterinary medicine	25
different brain	25
make sure	25
washed twice	25
old girl	25
cell layer	25
bbb permeability	25
perivascular cuffing	25
neurons showed	25
relapsing experimental	25
specific igg	25
age groups	25
rabbit anti	25
one dog	25
systemic inflammatory	25
current study	25
physical therapy	25
equine encephalitis	25
live attenuated	25
induced neurologic	25
weighted images	25
gi tract	25
treated patients	25
control study	25
imaging studies	25
guinea pigs	25
innate responses	25
cytolytic activity	25
drg neurons	25
showed increased	25
brain atrophy	25
serum levels	25
hematology oncology	25
early postnatal	25
brain activity	25
receptor antagonists	25
gain access	25
gfap expression	25
urinary catheter	25
iv cri	25
peripheral macrophages	25
autoimmune responses	25
years later	25
suppurative meningoencephalitis	25
immunodeficient mice	25
lesion formation	25
acute chest	25
lactate dehydrogenase	25
host response	25
healthy subjects	25
gc formation	25
healthy individuals	25
cells per	25
ca pyramidal	25
less likely	25
progressive disease	25
still unclear	25
eae model	25
airway obstruction	25
leukocyte migration	25
cultured astrocytes	25
myelin destruction	25
chest syndrome	25
progenitor cell	25
information processing	25
mental disorders	25
real time	24
differentially expressed	24
mmp expression	24
two major	24
recent advances	24
early stage	24
venezuelan equine	24
marked increase	24
naive mice	24
free radicals	24
eae mice	24
protein concentrations	24
significantly associated	24
phase i	24
less severe	24
see later	24
receptor activation	24
cell sorting	24
tissue culture	24
cns damage	24
activated cd	24
barre syndrome	24
infiltrating cd	24
expression analysis	24
north america	24
astrocyte cultures	24
different mechanisms	24
mhc antigens	24
primary cns	24
adult male	24
culture system	24
encephalitis associated	24
three days	24
bovine serum	24
marrow failure	24
three cases	24
mucous membranes	24
various types	24
plaque assay	24
cyclic nucleotide	24
following jhmv	24
per patient	24
signal intensity	24
induce demyelination	24
surface area	24
primary progressive	24
mouth disease	24
compact myelin	24
secondary lymphoid	24
subventricular zone	24
spleen cells	24
major cause	24
metastatic disease	24
inflammatory factors	24
acute encephalomyelitis	24
general population	24
olfactory dysfunction	24
i mhc	24
cxc chemokines	24
pivotal role	24
cell rna	24
studies will	24
i will	24
survival rates	24
rem sleep	24
fi rst	24
also demonstrated	24
cortical areas	24
facial nerve	24
neurons may	24
intervertebral disc	24
life science	24
hematopoietic cell	24
clinically significant	24
helper cells	24
fusion protein	24
programmed cell	24
cd low	24
examination revealed	24
expression profile	24
virus antigen	24
human ms	24
sclerosis multiple	24
genetic background	24
may appear	24
kg body	24
recently reported	24
hi granulocytes	24
days following	24
cell depletion	24
blood volume	24
plasma exchange	24
postnatal development	23
infected astrocytes	23
chronically infected	23
immune suppression	23
generation sequencing	23
leukemia virus	23
mhc expression	23
rat astrocytes	23
nasal cavity	23
fetal mri	23
heat shock	23
ebola virus	23
influenza viruses	23
urinary bladder	23
novel therapeutic	23
neuronal migration	23
functional receptor	23
er stress	23
nervous systems	23
patients presenting	23
may reveal	23
neurotrophic factors	23
specific asc	23
maintain hydration	23
free survival	23
effective treatment	23
neuronal dysfunction	23
viral envelope	23
reverse transcriptase	23
recent years	23
murine models	23
antibody levels	23
transplant recipients	23
sodium channel	23
th cytokine	23
distemper virus	23
side effect	23
mental health	23
viral protein	23
glutamate release	23
laboratory findings	23
two types	23
direct evidence	23
neuromyelitis optica	23
studies demonstrated	23
pulmonary disease	23
guinea pig	23
renal perfusion	23
associated glycoprotein	23
therapeutic targets	23
immune reaction	23
neuropsychiatric disorders	23
study suggests	23
ct scans	23
fever virus	23
feline immunodeficiency	23
gene therapy	23
normal controls	23
intracranial pressure	23
brain tumor	23
virus induced	23
neural activities	23
high incidence	23
system disease	23
spectrum antibiotics	23
much less	23
higher incidence	23
preliminary data	23
might contribute	23
retinoic acid	23
recognition receptors	23
myelinated axons	23
myelin formation	23
term effects	23
also seen	23
will help	23
wilms tumor	23
mediated disease	23
particular interest	23
lesser extent	23
energy metabolism	23
increasing evidence	23
pattern recognition	23
small intestine	23
clinical outcome	23
fear memory	23
one week	23
electrical stimulation	23
mast cells	22
labeled cells	22
synaptic activity	22
cell epitope	22
six cats	22
patients reported	22
clinical management	22
binding site	22
blood contamination	22
cells play	22
primary motor	22
markedly increased	22
fast blue	22
congestive heart	22
nucleus accumbens	22
high level	22
bystander activation	22
may serve	22
median survival	22
scid mice	22
necrotizing encephalopathy	22
also may	22
nervous tissue	22
cell viability	22
gut microbiome	22
derived macrophages	22
organ systems	22
th cm	22
keio univ	22
histological analysis	22
clinical manifestation	22
closely associated	22
mice using	22
day postinfection	22
combination therapy	22
medium containing	22
genes involved	22
fold higher	22
genetic testing	22
physiological conditions	22
older age	22
nerve fibers	22
result suggests	22
electrolyte abnormalities	22
significant changes	22
cell numbers	22
cba mice	22
i antigen	22
electrical activity	22
therapeutic strategy	22
largely unknown	22
united kingdom	22
infl uence	22
green fluorescent	22
affected area	22
ventricular dysrhythmias	22
diaphragmatic hernia	22
genes encoding	22
host disease	22
infected individuals	22
chronic viral	22
viruses may	22
cell membranes	22
animals showed	22
direct effect	22
immune evasion	22
vaccine development	22
mri showed	22
ewing sarcoma	22
trigeminal nerve	22
study period	22
respiratory infection	22
parkinson disease	22
infected cns	22
blood glucose	22
corona virus	22
also play	22
cord tissue	22
months later	22
treatment options	22
action potential	22
results obtained	22
also increased	22
conditioned medium	22
ido expression	22
zikv infection	22
riken bsi	22
neutrophil count	22
neural network	22
adoptively transferred	22
aseptically scrub	22
virus persistence	22
analysis using	22
complete remission	22
th cell	22
neuroprotective effect	22
rat anti	22
cc chemokines	22
molecular cloning	22
presumed secondary	22
induction therapy	22
disease burden	22
null mice	22
retrospective analysis	22
provide evidence	22
factor alpha	22
patients aged	22
focal lesions	21
two years	21
barrier permeability	21
national institutes	21
ace receptor	21
system inflammation	21
cell therapy	21
motor learning	21
functional roles	21
humoral responses	21
lymphocytic pleocytosis	21
human demyelinating	21
gauge needle	21
pulse oximetry	21
cns excitation	21
experimental infection	21
molecular layer	21
vitro stimulation	21
possible involvement	21
transmitter release	21
old boy	21
first line	21
will provide	21
lesion site	21
nerve regeneration	21
scar formation	21
brain swelling	21
antiviral activity	21
muscle tremors	21
serine protease	21
mice also	21
mice may	21
independent experiments	21
pertussis toxin	21
rrms patients	21
several months	21
diagnostic tests	21
receptor gene	21
studies show	21
infected cell	21
exome sequencing	21
successfully treated	21
may influence	21
neurological dysfunction	21
peripheral neuropathy	21
cancer therapy	21
lung disease	21
inflammatory conditions	21
leukocyte infiltration	21
allogeneic hematopoietic	21
induced cns	21
per day	21
prospective studies	21
cell immunity	21
treated rats	21
copy number	21
also show	21
neurologic symptoms	21
table ii	21
cytokine secretion	21
age range	21
recent data	21
jak stat	21
septic shock	21
recent evidence	21
increased numbers	21
primary infection	21
like disease	21
inflammatory lesions	21
system involvement	21
neurological sequelae	21
inhibitory effect	21
three times	21
low cd	21
will also	21
frontal lobe	21
allogeneic hct	21
nb rats	21
approximately one	21
virus spread	21
many years	21
chronic lesions	21
mouse cd	21
motor nucleus	21
abdominal ultrasound	21
blood transfusion	21
studies revealed	21
five cats	21
treg cells	21
response may	21
specific expression	21
seven patients	21
forming cells	21
quantitative analysis	21
well described	21
total body	21
acute inflammation	21
normal csf	21
blast cells	21
present within	21
term memory	21
human cd	21
small bowel	21
extracellular space	21
may suggest	21
one third	21
fos expression	21
survival rate	21
one month	21
embryonic day	21
may involve	21
nucleocapsid protein	21
draining lymph	21
surround suppression	21
kg sq	21
model system	21
da neurons	21
severe anemia	21
herpes zoster	21
positive correlation	21
susceptible individuals	21
induced encephalitis	21
also induced	20
human monocytes	20
sars patients	20
lymphoid tissues	20
enzyme activity	20
highly pathogenic	20
ciliary neurotrophic	20
significantly improved	20
adult human	20
chronic phase	20
nonsteroidal antiinflammatory	20
ischemic injury	20
oxygen delivery	20
clinical presentations	20
transgenic expression	20
effector mechanisms	20
somatosensory cortex	20
ganglion cells	20
neural development	20
hospital medical	20
vascular access	20
myelin repair	20
within minutes	20
neurodegenerative disorder	20
associated protein	20
clinical picture	20
may benefit	20
infect humans	20
adc values	20
tissue repair	20
root ganglion	20
immune privilege	20
mouse line	20
increased cd	20
ionizing radiation	20
toxicity include	20
brain macrophages	20
locus coeruleus	20
genetic susceptibility	20
replacement therapy	20
microglia express	20
autosomal recessive	20
factors may	20
interferon regulatory	20
respiratory illness	20
body mass	20
study also	20
blood stream	20
increased number	20
microglia play	20
glial cultures	20
surgical excision	20
underlying mechanism	20
relapsing multiple	20
rhesus monkeys	20
viral genome	20
synaptic inputs	20
enteric nervous	20
cns remyelination	20
cleveland clinic	20
neural circuits	20
apoptotic cell	20
high resolution	20
high cd	20
solitary tract	20
immunodominant epitope	20
olfactory system	20
specific receptor	20
showed mild	20
six months	20
brain research	20
also possible	20
applied biosystems	20
surgical intervention	20
chest ct	20
regulatory factor	20
gene transcription	20
eae models	20
subarachnoid space	20
among others	20
past years	20
increased production	20
specific cell	20
based protocols	20
specific manner	20
hepatic failure	20
weighted imaging	20
functional expression	20
membrane protein	20
cells using	20
assessed using	20
eye movements	20
autoimmune demyelination	20
neurotropic viral	20
sodium bicarbonate	20
normal range	20
cancer patients	20
mediated damage	20
ii mhc	20
cerebellar cortex	20
large numbers	20
positive astrocytes	20
pv strains	20
function within	20
cells showed	20
igg antibodies	20
complement system	20
pregnant women	20
express mhc	20
astroglial cells	20
killer cell	20
high concentrations	20
two dogs	20
viral invasion	20
significant improvement	20
male rats	20
matched controls	20
matter tracts	20
systemic infection	20
within months	20
mouse strain	20
open reading	20
analysis demonstrated	20
foxp treg	20
beneficial effect	20
western blotting	20
primary astrocytes	19
developmental stages	19
cutaneous lymphoma	19
oncology group	19
facs analysis	19
je mice	19
clinical use	19
mice developed	19
crystalloid fluid	19
medical science	19
eight patients	19
early acute	19
cell division	19
results support	19
presynaptic terminals	19
light microscopy	19
gastroprotectant drugs	19
mice per	19
brain samples	19
wallerian degeneration	19
chemokine gene	19
respiratory virus	19
mice resulted	19
american neurological	19
early response	19
disease characterized	19
possible mechanism	19
borne encephalitis	19
colony stimulating	19
gene transcripts	19
specific binding	19
cm cells	19
examination findings	19
cholinesterase inhibitors	19
cell clone	19
impaired consciousness	19
preliminary results	19
neurologic diseases	19
viral meningitis	19
plga nanoparticles	19
sample size	19
tissue sections	19
immunohistochemical study	19
ido activity	19
initial presentation	19
induced apoptosis	19
free radical	19
acute flaccid	19
receptor agonist	19
cell development	19
neuron cells	19
ethylene glycol	19
significantly greater	19
cognitive decline	19
animal species	19
low doses	19
fatal encephalitis	19
von willebrand	19
primary antibodies	19
rna polymerase	19
monocyte macrophage	19
within weeks	19
possible mechanisms	19
high mortality	19
vascular anomalies	19
disease models	19
ad mice	19
cause demyelination	19
resident cns	19
confocal microscopy	19
cns antigens	19
aspiration pneumonia	19
diseased animals	19
culture conditions	19
sodium channels	19
aged mice	19
cell effector	19
target cell	19
nagoya univ	19
effector phase	19
metropolitan institute	19
respiratory pattern	19
high degree	19
cns immune	19
neurologic signs	19
emergency department	19
cells might	19
induced central	19
also revealed	19
imaging modality	19
vivo studies	19
remitting ms	19
inflammatory monocyte	19
medulla oblongata	19
neurological association	19
synaptic vesicles	19
also result	19
endotracheal tube	19
culture medium	19
retrograde axonal	19
capsid protein	19
leukocyte recruitment	19
functional significance	19
tumour necrosis	19
fat diet	19
cns demyelinating	19
pathological findings	19
respiratory pathogens	19
also detected	19
control seizures	19
cause cns	19
inflammatory bowel	19
infected microglia	19
days prior	19
catheter placement	19
three groups	19
receptor signaling	19
occur within	19
direct ex	19
primary immunodeficiency	19
analgesic drugs	19
successful treatment	19
months post	19
treatment response	19
related disorders	19
receptor site	19
cell functions	19
following mhv	19
marrow transplant	19
reverse transcription	19
observed following	19
hydrogen peroxide	19
using anti	19
phase iii	19
well established	19
per group	19
toxic potential	19
many viruses	19
brain ischemia	19
mediated demyelinating	19
inflammatory effects	19
cancer institute	19
major depression	19
genetic analysis	19
canine lymphoma	19
derived growth	19
cytokine levels	19
fluid analysis	19
climate change	19
pulmonary complications	19
mental retardation	19
cns symptoms	19
life sciences	19
mutant mouse	19
inflammatory csf	18
acute leukemia	18
wound healing	18
red cell	18
systemic chemotherapy	18
intercostal space	18
viral model	18
term follow	18
respiratory coronaviruses	18
immediate early	18
least two	18
cultured hippocampal	18
enhancing lesions	18
mapk pathway	18
mixed glial	18
immune signaling	18
reactive astrogliosis	18
small cell	18
month old	18
animal care	18
alimentary lymphoma	18
review will	18
old mice	18
peripheral myelin	18
intraocular pressure	18
targeted therapies	18
affected animals	18
functional outcome	18
well defined	18
beta interferon	18
myocardial infarction	18
virus infects	18
tropical spastic	18
persistent virus	18
complete resolution	18
times post	18
one report	18
affective disorders	18
neonatal rat	18
results revealed	18
specific gene	18
primary cause	18
cns autoimmunity	18
slice culture	18
mice results	18
mouse central	18
using flow	18
inflammatory changes	18
brain infection	18
less commonly	18
envelope glycoproteins	18
intracerebral inoculation	18
responses following	18
pain control	18
pulmonary hypertension	18
causative agent	18
acute encephalopathy	18
cultured cortical	18
varicella zoster	18
demyelinating disorders	18
kidney injury	18
celiac disease	18
radial glia	18
medical record	18
virus infected	18
hev infection	18
virus vaccine	18
small molecule	18
luxol fast	18
factors including	18
spinal canal	18
vod sos	18
blood monocytes	18
old woman	18
gut microbiota	18
first days	18
mood disorders	18
myelinating schwann	18
drug metabolism	18
lateral ventricle	18
axon terminals	18
myelinated fibers	18
clinical significance	18
flow cytometer	18
preclinical studies	18
different time	18
cases may	18
cancer diagnosis	18
neural tissue	18
thiamine deficiency	18
late chronic	18
also induce	18
also associated	18
vascular permeability	18
whole exome	18
hematopoietic cells	18
alternative splicing	18
hypovolemic shock	18
behavioral changes	18
mice immunized	18
highly conserved	18
cfa containing	18
molecular profile	18
following exposure	18
receptor sites	18
respiratory rate	18
conduction block	18
rating scale	18
regulatory mechanisms	18
virus rna	18
cell interactions	18
dominant negative	18
vascular endothelium	18
mhc ii	18
may increase	18
food intake	18
specific memory	18
vena cava	18
acute necrotizing	18
may present	18
abdominal radiographs	18
positive results	18
every hours	18
cellular infiltration	18
study aimed	18
human fetal	18
different stages	18
contrast enhanced	18
soluble factors	18
cns depression	18
induction chemotherapy	18
constant rate	18
useful tool	18
globus pallidus	18
residual disease	18
experimental model	18
ifnar signaling	18
intranasal infection	18
storage diseases	18
tissue factor	18
familial hlh	18
ctl epitopes	18
intercellular adhesion	18
molecular characterization	18
critical period	18
brain endothelial	18
may improve	18
may indicate	18
cultured cells	18
binding domain	18
underlying disease	18
well characterized	18
feline coronavirus	18
memory cells	18
immunoglobulin superfamily	18
visual information	18
cells present	18
resting state	18
granulation tissue	18
small amounts	18
rat hippocampus	18
contrast enhancement	18
might also	18
kainic acid	18
evaluated using	17
cerebellar purkinje	17
spatial learning	17
glutamic acid	17
human microglia	17
acute hemorrhagic	17
critical roles	17
wildtype mice	17
cortical astrocytes	17
brainstem encephalitis	17
point mutation	17
disease induced	17
cough reflex	17
cutting edge	17
muscle cells	17
unpublished data	17
herpes virus	17
cases reported	17
allowed us	17
derived microglia	17
specific genes	17
pharmaceutical sciences	17
particularly important	17
may produce	17
immune mediated	17
signs may	17
mammalian brain	17
cell recognition	17
randomized controlled	17
retrospectively reviewed	17
sensitive dye	17
oligodendrocyte death	17
patch clamp	17
cells produce	17
severe combined	17
past decade	17
cell lineage	17
chemokine cxcl	17
lethal jhmv	17
later stages	17
intranasal administration	17
year post	17
perivascular macrophages	17
hlh group	17
therapeutic options	17
acute inflammatory	17
cognitive dysfunction	17
cognitive functions	17
maintenance therapy	17
memory formation	17
calcium channel	17
neurological disorder	17
viral gene	17
normal appearing	17
less frequently	17
two decades	17
simplex encephalitis	17
clinically isolated	17
also contribute	17
mixed agonist	17
expression within	17
cytotoxic cd	17
tap water	17
cord lesions	17
coronavirus spike	17
cell patch	17
included patients	17
induced disease	17
bmem conversion	17
warm water	17
like growth	17
japan science	17
toxic dose	17
gfp mice	17
systemic disease	17
throughout infection	17
rhesus macaques	17
tyrosine hydroxylase	17
previous reports	17
body surface	17
recombinant vaccinia	17
nerve cells	17
national cancer	17
several weeks	17
buffered saline	17
th th	17
visual stimuli	17
including cd	17
dth responses	17
activated protein	17
quantitative rt	17
cell phenotype	17
associated coronavirus	17
causes neuronal	17
mesenchymal stem	17
primary cultured	17
unpublished observations	17
cingulate cortex	17
glucose metabolism	17
translocator protein	17
dipeptidyl peptidase	17
immune systems	17
cns invasion	17
normal cns	17
cns autoimmune	17
clinical scores	17
predominantly expressed	17
active lesions	17
hippocampal slice	17
chlamydia pneumoniae	17
cient mice	17
cell accumulation	17
ms may	17
rna sequencing	17
viral ag	17
cov may	17
catheter hub	17
dna viruses	17
human patients	17
ca channel	17
multicenter study	17
organ damage	17
mrna level	17
relapsing eae	17
restricted cytotoxic	17
late effects	17
mildly elevated	17
associated acute	17
potential targets	17
neural progenitors	17
logistic regression	17
cell reactivity	17
molecular level	17
environmental risk	17
infected rl	17
located within	17
hematologic malignancies	17
virus replicates	17
pediatric radiologists	17
experimental studies	17
lumbar csf	17
may show	17
antiinflammatory drugs	17
physiological sciences	17
glioma cell	17
disease processes	17
inflammatory reactions	17
oncotic pressure	17
gc reactions	17
first time	17
platelet function	17
diagnostic accuracy	17
measured using	17
balamuthia mandrillaris	17
drug administration	17
liver biopsy	17
two main	17