quadgram

This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

quadgram	frequency
the central nervous system	759
in the central nervous	287
in the absence of	270
these results suggest that	250
of the central nervous	241
in the present study	169
has been shown to	169
in the cns of	161
in the presence of	159
severe acute respiratory syndrome	157
on the other hand	149
an important role in	139
as well as the	139
in the pathogenesis of	135
play a role in	135
at the time of	129
of cd t cells	120
in the spinal cord	120
brain and spinal cord	113
as a result of	107
for the treatment of	103
have been shown to	101
t cells in the	93
infection of the cns	93
it is important to	93
specific cd t cells	91
of mouse hepatitis virus	90
these results indicate that	89
cd and cd t	88
in the treatment of	85
and cd t cells	84
in the development of	83
in the context of	83
cd t cells in	83
play an important role	82
in vitro and in	81
is one of the	81
results suggest that the	81
acute respiratory syndrome coronavirus	81
it is possible that	80
west nile virus infection	78
cells in the cns	77
been shown to be	76
as well as in	76
one of the most	76
vitro and in vivo	73
in the brain and	72
a role in the	72
model of multiple sclerosis	71
these data suggest that	70
in the case of	70
middle east respiratory syndrome	70
of the immune system	69
of the spinal cord	69
to the development of	68
infection of the central	68
in the united states	68
of this study was	66
central nervous system of	66
patients with multiple sclerosis	66
has been associated with	65
the brain and spinal	65
in the regulation of	65
is the most common	65
studies have shown that	63
in the cerebrospinal fluid	63
in the brain of	63
graduate school of medicine	63
of central nervous system	62
in a patient with	62
of experimental autoimmune encephalomyelitis	62
these findings suggest that	61
this study was to	61
in the nervous system	61
may be associated with	58
little is known about	58
glial fibrillary acidic protein	58
of the nervous system	58
in the form of	58
in mice infected with	57
in the cns and	57
our results suggest that	56
a critical role in	55
the presence of a	54
mbp tcr transgenic mice	54
important role in the	54
is thought to be	53
of the immune response	53
ifnar fl fl mice	53
at the end of	52
is involved in the	51
in experimental autoimmune encephalomyelitis	51
within the central nervous	51
an increase in the	51
in the white matter	50
can be used to	50
has been reported in	50
in addition to the	50
it has been shown	49
in patients with ms	49
into the central nervous	49
in the brains of	49
be involved in the	49
inducible nitric oxide synthase	48
in the csf of	48
the aim of this	48
on the surface of	48
in a variety of	48
in dogs and cats	48
plays an important role	47
may play a role	47
with a neurotropic coronavirus	47
university graduate school of	46
the purpose of this	46
after spinal cord injury	45
viral infection of the	45
the role of the	45
for the development of	45
of west nile virus	45
cd t cells were	45
cd c t cells	44
in the expression of	44
central nervous system in	43
is associated with a	43
mgfapcre ifnar fl fl	43
to be associated with	43
university school of medicine	42
have been associated with	42
of the risk of	42
on the basis of	42
a member of the	42
the spinal cord of	42
with sickle cell disease	42
plays a role in	42
in the course of	42
chemokines and chemokine receptors	42
the course of the	42
of borna disease virus	41
to be involved in	41
has been reported to	41
in a mouse model	41
in contrast to the	41
at the same time	41
a retrospective chart review	41
a large number of	41
a significant increase in	40
at the site of	40
has been shown that	40
the cerebrospinal fluid of	40
has been suggested that	40
in the number of	40
it has been suggested	40
east respiratory syndrome coronavirus	40
because of the risk	40
was found to be	40
is known about the	39
of severe acute respiratory	39
review of the literature	39
it was found that	39
the vast majority of	39
a mouse model of	39
during the course of	39
mg kg po q	38
and tumor necrosis factor	38
may be due to	38
at the level of	38
we found that the	38
the level of the	38
the peripheral nervous system	38
of patients with ms	38
and the presence of	37
of mhc class i	37
were observed in the	37
cells into the cns	37
cd t cells are	37
a wide range of	37
cells within the cns	37
the expression of the	37
the blood brain barrier	37
central nervous system during	37
in the induction of	36
central nervous system and	36
of myelin basic protein	36
in the control of	36
we have shown that	36
may contribute to the	36
entry into the cns	36
was observed in the	36
were found to be	35
acute respiratory distress syndrome	35
may be involved in	35
myelin basic protein and	35
aim of this study	35
innate and adaptive immune	35
viral infections of the	35
in patients with covid	35
purpose of this study	34
to play a role	34
for the presence of	34
central nervous system infection	34
hematopoietic stem cell transplantation	34
it is likely that	34
cells of the cns	34
the end of the	34
in a model of	34
experimental allergic encephalomyelitis in	34
a crucial role in	33
in the diagnosis of	33
to the central nervous	33
the pathogenesis of ms	33
in the cns is	33
have been reported in	33
gene expression in the	33
cd t cell response	33
brains and spinal cords	33
by the presence of	33
this is the first	33
a wide variety of	33
in the setting of	33
examined the effects of	33
have been implicated in	33
can be associated with	33
the development of a	32
of cd c microglia	32
ly c hi monocytes	32
presence or absence of	32
the cns of mice	32
in the cns during	32
are involved in the	32
t cells within the	31
of experimental allergic encephalomyelitis	31
in the olfactory bulb	31
in balb c mice	31
cells isolated from the	31
a major role in	31
was detected in the	31
of microglia in the	31
mice infected with a	31
our results indicate that	31
in this study we	30
infiltration into the cns	30
cd t cell responses	30
the immune response to	30
in patients with severe	30
clinical signs associated with	30
t cell responses in	30
cells in multiple sclerosis	30
a retrospective study of	30
of a patient with	30
have been reported to	30
it has been reported	30
in central nervous system	30
of cd foxp tregs	30
peripheral blood mononuclear cells	29
play a critical role	29
in an attempt to	29
were found in the	29
u r n a	29
a l p r	29
are more likely to	29
r n a l	29
the early stages of	29
o u r n	29
n a l p	29
l p r e	29
to the pathogenesis of	29
access to the cns	29
under the control of	29
for a minimum of	29
in patients with multiple	29
j o u r	29
be due to the	29
r o o f	29
p r o o	29
is associated with the	29
the spinal cord and	29
with the exception of	29
of this study is	29
in the pathophysiology of	29
there was no significant	29
it was shown that	29
and central nervous system	28
major histocompatibility complex class	28
from the cns of	28
white matter of the	28
to the presence of	28
the results suggest that	28
an animal model of	28
infected with a neurotropic	28
is characterized by a	28
in the cerebral cortex	28
this study is to	28
strain of mouse hepatitis	28
is based on the	28
from the central nervous	28
been reported to be	28
followed by administration of	28
the risk of developing	28
also been shown to	28
should be considered in	28
in the substantia nigra	28
memory cd t cells	28
in the pediatric population	28
the absence of cd	28
the white matter of	28
isolated from the cns	28
a key role in	28
the presence of the	28
we have previously shown	27
it has also been	27
kg po q h	27
in a number of	27
the treatment of ms	27
in the majority of	27
retrospective chart review of	27
coronavirus infection of the	27
systematic review and meta	27
for the study of	27
may be related to	27
had no effect on	27
mice at day p	27
of the inflammatory response	27
was found to have	27
course of the disease	27
chemokines and their receptors	27
with the presence of	27
of nitric oxide synthase	27
of the patients with	27
t cell response to	27
administration of activated charcoal	27
respiratory syncytial virus infection	26
the presence or absence	26
in vivo and in	26
are present in the	26
increased the number of	26
is known to be	26
infection in the cns	26
investigated the effect of	26
after the onset of	26
of ctl escape mutants	26
riken brain science institute	26
in a dog with	26
for the diagnosis of	26
herpes simplex virus type	26
has been reported that	26
results indicate that the	26
the present study was	26
here we show that	26
have previously shown that	25
infection of mice with	25
patients with sickle cell	25
in mgfapcre ifnar fl	25
in animal models of	25
the tip of the	25
it is known that	25
of hospitalized patients with	25
and the development of	25
disease of the central	25
these data indicate that	25
in the bone marrow	25
of major histocompatibility complex	25
in multiple sclerosis and	25
ccr cd foxp tregs	25
west nile virus encephalitis	25
virus infection of the	25
in the cns in	25
in the peripheral blood	25
mhc class i expression	25
expression in the central	25
has been described in	25
of patients with multiple	25
as well as a	25
central nervous system the	25
with the development of	24
our data suggest that	24
are found in the	24
by cd t cells	24
is important to note	24
t cells specific for	24
a reduction in the	24
cells as well as	24
as well as their	24
over the course of	24
a significant decrease in	24
cd t cells and	24
in multiple sclerosis lesions	24
one of the major	24
multiple sclerosis multiple sclerosis	24
in pediatric patients with	24
within the cns is	24
with a history of	24
cells in the central	24
phase of the disease	24
that the presence of	24
as well as to	24
our results show that	24
infections of the central	24
is a member of	24
models of multiple sclerosis	24
mhc class i and	24
the ability of the	24
in the process of	24
in the management of	24
the total number of	24
mhc class ii expression	24
at the onset of	24
we examined the effects	24
respiratory syndrome coronavirus infection	24
important to note that	24
of neurons in the	24
is essential for the	24
experimental autoimmune encephalomyelitis in	24
central nervous system disease	23
has also been reported	23
middle cerebral artery occlusion	23
more likely to have	23
investigated the effects of	23
could be involved in	23
a systematic review and	23
leukemia in a dog	23
studies are needed to	23
the onset of the	23
c hi monocytes and	23
the acute phase of	23
examined the effect of	23
and adaptive immune responses	23
was associated with a	23
critical role in the	23
vivo and in vitro	23
infections of the cns	23
in mice transgenic for	23
both cd and cd	23
role of cd t	23
the cause of the	23
there was no difference	23
and the role of	23
cells in the brain	23
the location of the	23
the size of the	23
the use of a	22
diseases of the central	22
the mechanisms by which	22
that cd t cells	22
with severe acute respiratory	22
nitric oxide synthase in	22
cd foxp tregs in	22
play important roles in	22
these findings indicate that	22
role in the pathogenesis	22
t cells isolated from	22
the immune response in	22
the surface of the	22
are the most common	22
for the detection of	22
the nature of the	22
virus in the cns	22
it has been demonstrated	22
into the cns and	22
class i and class	22
have been described in	22
of cd and cd	22
a review of the	22
of inducible nitric oxide	22
as a consequence of	22
increase the risk of	22
by in situ hybridization	22
the development of the	22
the relationship between the	22
in the hippocampus of	22
the cns through the	22
the role of cd	22
in the rat brain	22
the possible role of	21
as one of the	21
of a number of	21
of the role of	21
a total of patients	21
been implicated in the	21
of the myelin sheath	21
is characterized by the	21
to be due to	21
increase in the number	21
an increased risk of	21
were found to have	21
or perform orogastric lavage	21
for the induction of	21
with the use of	21
to the spinal cord	21
c bl mice were	21
in support of this	21
it is clear that	21
of multiple sclerosis patients	21
has been implicated in	21
plays a critical role	21
role of microglia in	21
national institutes of health	21
might be involved in	21
the magnitude of the	21
myelin basic protein in	21
an important role for	21
both in vitro and	21
in the ca region	21
in multiple sclerosis patients	21
and review of the	21
the pathogenesis of the	21
risk of developing ms	21
absence of cd t	21
experimental autoimmune encephalomyelitis by	21
it is difficult to	21
is consistent with the	21
is expressed in the	21
significant increase in the	21
that there is a	20
in the optic nerve	20
be used as a	20
are associated with a	20
in order to determine	20
this work was supported	20
of morbidity and mortality	20
no significant difference in	20
that the expression of	20
mhv infection of the	20
most common cause of	20
was also observed in	20
in experimental allergic encephalomyelitis	20
to enter the cns	20
these data demonstrate that	20
sod g a mice	20
the innate immune system	20
the first case of	20
there was a significant	20
of feline infectious peritonitis	20
central nervous system inflammation	20
has been demonstrated that	20
in the peripheral nervous	20
a median age of	20
of middle east respiratory	20
the severity of the	20
the role of microglia	20
such as multiple sclerosis	20
been found to be	20
in the early stages	20
of ccr cd foxp	20
by an increase in	20
c bl j mice	20
was shown to be	20
the case of a	20
can be used as	20
mice transgenic for human	20
remains to be determined	20
was the most common	20
at days and p	20
present in the cns	20
if the patient is	20
not appear to be	20
may be helpful in	20
has been demonstrated in	20
and are associated with	20
the csf of patients	20
in the activation of	20
nervous system of mice	20
csf of ms patients	20
there is no evidence	20
from multiple sclerosis patients	20
the majority of cases	20
on the role of	20
role in the regulation	19
has been found to	19
for the control of	19
data suggest that the	19
the leading cause of	19
the formation of the	19
are responsible for the	19
in a study of	19
of microglia and astrocytes	19
may be important in	19
have been found in	19
these results demonstrate that	19
for cd t cells	19
has been detected in	19
in children with scd	19
were detected in the	19
of the present study	19
have the potential to	19
a marked increase in	19
we examined the effect	19
and peripheral nervous system	19
of herpes simplex virus	19
in the spinal cords	19
national institute for physiological	19
the diagnosis of ms	19
increases the risk of	19
of mhc class ii	19
reported in the literature	19
virus from the cns	19
of spinal cord injury	19
we also found that	19
does not appear to	19
t cells and macrophages	19
of sr t cells	19
be one of the	19
is likely to be	19
the function of the	19
the control of the	19
and is characterized by	19
central and peripheral nervous	19
a decrease in the	19
it is not known	19
of the brain and	19
of human coronavirus oc	19
a significant reduction in	19
we have demonstrated that	19
to the cns and	19
fluids to maintain hydration	19
the most common cause	19
b cells in the	19
found in the cns	19
these results suggested that	19
to a lesser extent	19
in the evaluation of	19
were more likely to	19
has been used to	19
can be found in	19
by administration of activated	19
to myelin basic protein	19
induced central nervous system	19
in multiple sclerosis brain	19
to the level of	19
tumor necrosis factor alpha	19
the natural history of	18
histocompatibility complex class i	18
in the brain stem	18
treatment of multiple sclerosis	18
the effects of the	18
the university of tokyo	18
specific cd t cell	18
cells are present in	18
detected in the cns	18
induce emesis or perform	18
macrophages and dendritic cells	18
similar to that of	18
a better understanding of	18
but not in the	18
a major cause of	18
these observations suggest that	18
gain access to the	18
in the adult brain	18
investigate the role of	18
sections were stained with	18
has not yet been	18
cd hi cd b	18
the immune system in	18
has also been shown	18
emesis or perform orogastric	18
regions of the brain	18
national institute of neuroscience	18
have been used to	18
early in the course	18
have shown that the	18
induction of experimental autoimmune	18
may or may not	18
virus infection in the	18
cd low cd b	18
with a median age	18
the importance of the	18
mhc class i molecules	18
play a key role	18
it is thought that	18
did not affect the	18
pathogenesis of multiple sclerosis	18
of a neurotropic coronavirus	18
we investigated the effect	18
a rat model of	18
the enteric nervous system	18
hematopoietic stem cell transplant	18
stages of the disease	18
infection with a neurotropic	18
i and class ii	18
and chemokine receptors in	18
the majority of the	18
the onset of disease	18
may be responsible for	18
with clinical signs of	18
there is no known	18
neuroinvasive potential of sars	18
white blood cell count	18
a significant role in	18
in an animal model	18
and the pathogenesis of	18
t cells into the	18
with a variety of	18
clinical signs of toxicity	18
neuronal death in the	18
a risk factor for	18
have been detected in	18
be responsible for the	18
mechanism of action of	18
it is well known	17
to better understand the	17
cd t cells during	17
study was to evaluate	17
csf of patients with	17
of the presence of	17
in the generation of	17
has not been reported	17
can be caused by	17
be detected in the	17
diseases of the cns	17
can be treated with	17
are known to be	17
metropolitan institute for neuroscience	17
glial cells in the	17
can be detected in	17
in the spleen and	17
have been identified in	17
is necessary for the	17
we have reported that	17
mouse central nervous system	17
the world health organization	17
from central nervous system	17
an essential role in	17
appears to be a	17
of astrocytes in the	17
of cd t cell	17
at the peak of	17
the expression levels of	17
and the expression of	17
a small number of	17
to an increase in	17
of neural stem cells	17
cd high cd b	17
of ccl in the	17
of the cns and	17
animal care and use	17
has been identified as	17
was to evaluate the	17
the brain and the	17
in the current study	17
mice were infected with	17
tokyo metropolitan institute for	17
was no significant difference	17
has the potential to	17
at the university of	17
with mouse hepatitis virus	17
in the frequency of	17
be related to the	17
in c bl mice	17
neurons and glial cells	17
in a series of	17
are likely to be	17
we investigated the effects	17
cerebrospinal fluid of a	17
in the formation of	17
was found in the	17
patients with coronavirus disease	17
based on clinical signs	17
of mice infected with	17
disease of the cns	17
institute for physiological sciences	17
of the most common	17
the cns and the	17
can be used for	17
t cells have been	17
in the differential diagnosis	17
selection of ctl escape	17
have been found to	17
have also been reported	16
on the cell surface	16
viral load in the	16
department of anatomy and	16
venezuelan equine encephalitis virus	16
the functional role of	16
have also been shown	16
may play an important	16
animal models of ms	16
no effect on the	16
be the result of	16
on the type of	16
children and young adults	16
the authors declare that	16
chemokines in the cns	16
we performed a retrospective	16
for the regulation of	16
in the corpus callosum	16
for the majority of	16
rat central nervous system	16
in the production of	16
can be used in	16
expression of mhc class	16
t cells from the	16
and cd t cell	16
in the dog and	16
play a crucial role	16
cause of morbidity and	16
of acute and chronic	16
and magnetic resonance imaging	16
for the first time	16
demyelinating disease of the	16
the cd t cell	16
the time of presentation	16
play a significant role	16
in the study of	16
t cell responses to	16
by the fact that	16
work was supported by	16
of the cns that	16
immune response in the	16
kg iv q h	16
infections in the nervous	16
the patient should be	16
was no difference in	16
it is worth noting	16
the critical role of	16
cd t cells have	16
the absence of any	16
a pivotal role in	16
central nervous system requires	16
in the mouse brain	16
in patients with scd	16
was used as a	16
mg kg iv q	16
we have examined the	16
the dog and cat	16
a result of the	16
as a marker for	16
a case report of	16
in the adult mouse	16
plays a crucial role	16
in a rat model	16
a transgenic mouse model	16
japan science and technology	16
the cns of mhv	16
of patients infected with	16
institutional animal care and	16
is well known that	16
be associated with the	16
are expressed in the	16
to be responsible for	16
spinal cord injury in	16
response to viral infection	16
no significant differences in	16
is dependent on the	16
the absence of a	16
the neuroinvasive potential of	16
late chronic demyelinating disease	16
been shown to reduce	16
were included in the	16
t cells in multiple	16
number of t cells	15
entry into the central	15
in mouse models of	15
viral replication in the	15
in west nile virus	15
and ido ko mice	15
for the evaluation of	15
of reactive oxygen species	15
infection of the brain	15
at months of age	15
in relation to the	15
in dogs with lymphoma	15
mouse hepatitis virus a	15
play a major role	15
the activation of the	15
of autoreactive t cells	15
kyushu institute of technology	15
it is possible to	15
in the dentate gyrus	15
administer intravenous fluids to	15
for myelin basic protein	15
are believed to be	15
frequency and number of	15
as well as other	15
is due to a	15
and is associated with	15
at weeks of age	15
the spinal cords of	15
to the lack of	15
virus from the central	15
the most common form	15
role of ccr in	15
been detected in the	15
the present study we	15
a complete blood count	15
were washed twice with	15
in situ hybridization and	15
was significantly higher in	15
of multiple sclerosis in	15
isolation and characterization of	15
in response to the	15
and the spinal cord	15
of the dentate gyrus	15
may be required to	15
borna disease virus infection	15
been shown to have	15
inflammatory cytokines and chemokines	15
major role in the	15
of the virus to	15
spinal cord white matter	15
the mouse central nervous	15
the role of these	15
brain or spinal cord	15
cd t cell epitope	15
of semliki forest virus	15
on the use of	15
retrospective study of cases	15
was similar to that	15
response in the cns	15
was supported by the	15
progression of the disease	15
in the blood of	15
and clinical characteristics of	15
compared to wt mice	15
have been observed in	15
it is not clear	15
at least in part	15
we have developed a	15
can be induced by	15
have not yet been	15
model for multiple sclerosis	15
feline infectious peritonitis virus	15
is supported by the	15
virus entry into the	15
increase the number of	15
cells of the central	15
the csf of ms	15
the expression of these	15
cd t cells from	15
a central role in	15
coronavirus mouse hepatitis virus	15
intravenous fluids to maintain	15
for the generation of	15
of the t cell	15
cd foxp gfp tregs	15
is not required for	15
in progressive multiple sclerosis	15
it is necessary to	15
specific t cells in	15
may be necessary to	15
involved in the regulation	15
a viral model of	15
experimental autoimmune encephalomyelitis and	15
to be able to	15
study of dogs with	15
were not significantly different	15
required for viral clearance	15
the adoptive transfer of	15
secondary progressive multiple sclerosis	15
control of viral replication	15
the respiratory failure of	15
with the severity of	15
on the presence of	15
g for min at	15
respiratory failure of covid	15
for the management of	15
at the age of	15
we were able to	15
during the study period	15
the chemokine receptor ccr	15
by a variety of	15
in the developing brain	14
the time course of	14
fluid of patients with	14
administer intravenous crystalloid fluids	14
in the basal ganglia	14
the severity of demyelination	14
also been reported in	14
infection in the central	14
in the serum of	14
cells in the pathogenesis	14
d d i f	14
expression of inducible nitric	14
that the majority of	14
there was no evidence	14
death in the absence	14
suggesting a role for	14
gray and white matter	14
hi monocytes and ly	14
the objective of this	14
retrospective chart review was	14
the quality of life	14
be associated with a	14
of the disease is	14
for viral clearance from	14
of the virus in	14
t d d i	14
be considered in the	14
transgenic for human ace	14
mouse hepatitis virus strain	14
infectious diseases of the	14
contribute to the development	14
cytokines such as il	14
with central nervous system	14
the immune system and	14
did not show any	14
as there is no	14
cytokines in the cns	14
has yet to be	14
one of the main	14
cerebrospinal fluid of patients	14
the results of the	14
to play an important	14
to be expressed in	14
significant difference in the	14
the aim of the	14
in a viral model	14
the involvement of the	14
might be due to	14
within the spinal cord	14
d i f f	14
in the use of	14
chemokine receptors in the	14
to address this issue	14
cd t cells within	14
a murine model of	14
between the ages of	14
of cells in the	14
have been demonstrated to	14
we show that the	14
analysis was performed using	14
patients with and without	14
and astrocytes in the	14
to investigate the role	14
the pathogenesis of multiple	14
in the brain is	14
the national institutes of	14
is responsible for the	14
cns of mice with	14
to the site of	14
objective of this study	14
cd t cells was	14
may be useful in	14
in health and disease	14
cd t cells to	14
is considered to be	14
of chemokines and chemokine	14
mhc class i antigen	14
more likely to be	14
of tumor necrosis factor	14
the absence of ifn	14
in the acute phase	14
of the most important	14
with a diagnosis of	14
and function of the	14
virus infection in mice	14
by mouse hepatitis virus	14
inflammatory cytokines such as	14
to the brain and	14
systemic inflammatory response syndrome	14
and to a lesser	14
with respiratory syncytial virus	14
by the expression of	14
for min on ice	14
respiratory syndrome coronavirus in	14
the lower respiratory tract	14
of multiple sclerosis lesions	14
the innate immune response	14
of nk cells in	14
demyelination in mice infected	14
in a subset of	14
school of pharmaceutical sciences	14
the developing nervous system	14
are similar to those	14
into the cns of	14
found in the csf	14
will be discussed in	14
in the initiation of	14
the virus in the	14
by the finding that	14
children with sickle cell	14
in the respiratory failure	14
expressed in the cns	14
role in the respiratory	14
in gfapcr d mice	14
one of the first	14
that are associated with	14
during the development of	14
science and technology agency	14
mrna expression in the	14
do not appear to	14
as a source of	14
nervous system infection by	14
mice infected with mhv	13
chronic progressive multiple sclerosis	13
could contribute to the	13
to that observed in	13
we previously reported that	13
safety and efficacy of	13
coronavirus in the central	13
are thought to be	13
clinical signs of respiratory	13
dopaminergic neurons in the	13
human immunodeficiency virus type	13
of fresh frozen plasma	13
a case series of	13
and clinical features of	13
and the immune system	13
in accordance with the	13
findings suggest that the	13
thought to play a	13
is determined by the	13
glial cells and neurons	13
jhm strain of mouse	13
there were no significant	13
neurological manifestations of covid	13
may be present in	13
intravenous crystalloid fluids to	13
it is suggested that	13
and the number of	13
causes neuronal death in	13
the chemokine receptor cxcr	13
understand the role of	13
observed in patients with	13
with borna disease virus	13
samples from patients with	13
the central and peripheral	13
the expression of il	13
is believed to be	13
responses in the central	13
to a variety of	13
recruited to the cns	13
our understanding of the	13
seen in patients with	13
onset of the disease	13
with human immunodeficiency virus	13
in the cns at	13
may be an important	13
food and drug administration	13
we have found that	13
of chemokines in the	13
a constant rate infusion	13
in the gray matter	13
signs of respiratory distress	13
first case of meningitis	13
been associated with a	13
a significant proportion of	13
it has been proposed	13
and myelin basic protein	13
the treatment of choice	13
a retrospective review of	13
of dogs with lymphoma	13
found to have a	13
japanese encephalitis virus infection	13
in up to of	13
of the disease and	13
plays a major role	13
shown to have a	13
the expression level of	13
central nervous system viral	13
the active ingredient in	13
of encephalitis in mice	13
when compared to the	13
of the patient with	13
efficacy and safety of	13
viral model of multiple	13
in the brain parenchyma	13
is important for the	13
syndrome coronavirus infection causes	13
to be one of	13
well as in the	13
cellular and molecular mechanisms	13
by human coronavirus oc	13
significantly higher in the	13
sensitivity and specificity of	13
we will discuss the	13
of lymphocytic choriomeningitis virus	13
is worth noting that	13
manifestations of hospitalized patients	13
a higher risk of	13
expression of proinflammatory cytokines	13
in patients with chronic	13
a number of different	13
and spinal cord of	13
here we report that	13
the mhc class i	13
within the cns during	13
ccr cd foxp gfp	13
further studies are needed	13
chemokine expression in the	13
with an increase in	13
coronavirus infection causes neuronal	13
response in the central	13
of cd c t	13
clearance of mouse hepatitis	13
care and use committee	13
h at room temperature	13
before the age of	13
not been reported in	13
allogeneic hematopoietic stem cell	13
graduate school of medical	13
the development of an	13
cells were washed twice	13
viral infections in the	13
with respect to the	13
has been proposed that	13
or may not be	13
of t cells and	13
at increased risk for	13
a growing body of	13
as the cause of	13
that the number of	13
to be effective in	13
in cd t cells	13
of the cns are	13
can be seen in	13
is the use of	13
in astrocytes and microglia	13
of patients with covid	13
graduate school of pharmaceutical	13
associated with an increased	13
coronavirus in the brain	13
the clinical course of	13
into the brain parenchyma	13
the length of the	13
of the disease in	13
of the blood brain	13
during experimental autoimmune encephalomyelitis	13
of the cns in	13
cells in response to	13
better understanding of the	13
the absence of encephalitis	13
in the face of	13
with the addition of	13
of t cells in	13
in response to viral	13
is required for viral	13
with myelin basic protein	13
the results of this	13
the induction of the	13
encephalitis in mice transgenic	13
into the cns is	13
infection causes neuronal death	13
treatment of patients with	13
the primary cause of	13
at the start of	13
is related to the	13
the etiology of ms	13
the primary visual cortex	13
characteristics of cases of	13
a patient with a	13
in the adult cns	13
expression in the cns	13
the potential role of	13
place an intravenous catheter	13
through the activation of	13
are consistent with the	13
syndrome associated with sars	13
the basis of the	13
are not well understood	13
were isolated from the	13
in mice lacking the	13
the adaptive immune response	13
is the active ingredient	13
of these cells in	13
can be induced in	13
absence of encephalitis in	13
we conducted a retrospective	13
studies have suggested that	13
role of the chemokine	13
in a murine model	13
to the induction of	13
most common form of	13
in response to a	13
cytotoxic t cell response	12
at different time points	12
for the initiation of	12
has granted medrxiv a	12
study of patients with	12
to the use of	12
a study of dogs	12
a higher incidence of	12
the chemokine mig in	12
under years of age	12
test was used to	12
th cells in the	12
display the preprint in	12
for this preprint this	12
the nervous system and	12
involved in the pathogenesis	12
virus targeting the cns	12
of the olfactory bulb	12
the intensive care unit	12
spinal cord of mice	12
aid for scientific research	12
could be associated with	12
washed twice with pbs	12
of macrophages and microglia	12
infiltrating cd b cells	12
th and th cells	12
of the corpus callosum	12
the effector phase of	12
of the chemokine mig	12
was not detected in	12
has been observed in	12
a dramatic increase in	12
of multiple sclerosis the	12
disruption of the blood	12
and young adults with	12
this preprint this version	12
central nervous system oligodendroglia	12
been reported in the	12
tokyo university of agriculture	12
be found in the	12
starting at day p	12
is more common in	12
in the olfactory epithelium	12
and it has been	12
detected in the csf	12
lethal west nile virus	12
diagnosis and management of	12
preprint this version posted	12
this suggests that the	12
is made based on	12
the activity of the	12
chronic relapsing experimental allergic	12
granted medrxiv a license	12
is associated with increased	12
the preprint in perpetuity	12
myelin basic protein gene	12
gastroprotectant and antiemetic drugs	12
medrxiv a license to	12
emesis or orogastric lavage	12
the duration of the	12
detected in the brain	12
role of astrocytes in	12
inflamed central nervous system	12
of a child with	12
to display the preprint	12
spinal cord grey matter	12
the myelin basic protein	12
the copyright holder for	12
of sickle cell disease	12
is based on clinical	12
direct ex vivo elispot	12
class ii expression on	12
viral diseases of the	12
viral infection in the	12
compared to that of	12
the early phase of	12
the nervous system is	12
through the use of	12
an overview of the	12
production of inflammatory cytokines	12
is observed in the	12
has been used for	12
in cats with lymphoma	12
treated mice compared to	12
the cd c microglia	12
the distribution of the	12
copyright holder for this	12
the possibility that the	12
mhc class ii molecules	12
clinical features of patients	12
cd c microglia in	12
of monocyte chemoattractant protein	12
for a total of	12
the risk of causing	12
the rat central nervous	12
of virus in the	12
normal appearing white matter	12
syndrome coronavirus in the	12
compared to wild type	12
class i and ii	12
has not been well	12
the olfactory bulb and	12
not detected in the	12
of gaba a receptors	12
than years of age	12
central nervous system a	12
associated with the development	12
for the pathogenesis of	12
replication in the cns	12
in comparison with the	12
as part of the	12
t cells are not	12
these results suggest the	12
have a role in	12
ccl in the cns	12
findings indicate that the	12
chemokine mig in pathogenesis	12
virus infections in the	12
evidence of the covid	12
also play a role	12
of viral replication in	12
is caused by a	12
expression in the brain	12
allergic encephalomyelitis in the	12
traumatic spinal cord injury	12
is no known antidote	12
and natural killer cells	12
onset of clinical signs	12
the mechanism by which	12
to maintain hydration and	12
observed in the cns	12
a high degree of	12
cases with pulmonary edema	12
the integrity of the	12
cell responses in the	12
is the author funder	12
support the hypothesis that	12
in addition to their	12
cells to the cns	12
cov may play a	12
in the cns were	12
a license to display	12
holder for this preprint	12
in a case of	12
the onset of clinical	12
infections of the nervous	12
with mbp in cfa	12
the major histocompatibility complex	12
spinal cord and brain	12
which is associated with	12
specific cd and cd	12
with the onset of	12
our findings suggest that	12
the cns during the	12
the development of new	12
between days and p	12
make sure that the	12
astrocytes and microglia in	12
the results indicate that	12
matter of the brain	12
cells in the spleen	12
specific for myelin basic	12
of the s protein	12
this version posted july	12
support the idea that	12
detection of severe acute	12
the upper respiratory tract	12
viral clearance from the	12
nile virus infection in	12
expressed in the brain	12
morbidity and mortality in	12
a central role for	12
and their receptors in	12
the differential diagnosis of	12
the time of the	12
kg minute iv cri	12
for h at room	12
has been shown in	12
results show that the	12
chronic central nervous system	12
and the absence of	12
license to display the	12
during the acute phase	12
involved in the development	12
it was suggested that	12
and some of them	12
in the migration of	12
antigen was detected in	12
a cd t cell	12
in the liver and	12
susceptible strains of mice	12
in the cns are	12
as shown in fig	12
could be detected in	12
borna disease virus in	12
reduce the risk of	12
the rest of the	12
immune response to the	12
potential role of the	12
may be caused by	12
who has granted medrxiv	12
the expression of a	11
by myelin basic protein	11
as a marker of	11
of type i ifn	11
group than in the	11
mg kg body weight	11
of the expression of	11
cells were incubated with	11
resident cells of the	11
clearance from the cns	11
in the levels of	11
with severe hemophilia a	11
both th and th	11
mouse hepatitis virus from	11
these studies suggest that	11
more than of the	11
spread of a neurotropic	11
resulted in a significant	11
of dogs with mm	11
pet with f fedac	11
been identified as a	11
of the cns is	11
can be administered to	11
ctl escape mutants in	11
were no significant differences	11
for their ability to	11
through the olfactory bulb	11
as well as by	11
absence of rnase l	11
bl and ido ko	11
lines by human coronavirus	11
the host immune response	11
contribute to the pathogenesis	11
to mg kg iv	11
entry into the brain	11
our results revealed that	11
to increase the number	11
to be the most	11
of the white matter	11
with regard to the	11
mice were treated with	11
effector function within the	11
a mutation in the	11
the thickness of the	11
to years of age	11
may be required for	11
within the cns and	11
reactive t cells in	11
plays an essential role	11
a small proportion of	11
in the severity of	11
mice infected with the	11
viral clearance from central	11
acute spinal cord injury	11
of pediatric patients with	11
the absence of rnase	11
the selection of ctl	11
should be treated with	11
to contribute to the	11
were infected with jev	11
a small amount of	11
the left and right	11
the adaptive immune system	11
at the molecular level	11
used in this study	11
the cns results in	11
in the visual cortex	11
japan it has been	11
and the risk of	11
reduction in the severity	11
the number of t	11
induction of nitric oxide	11
the center of the	11
do not induce emesis	11
to west nile virus	11
the fact that the	11
studies have demonstrated that	11
brainstem encephalitis plus pulmonary	11
similar to that observed	11
with the ability to	11
encephalitis associated with sars	11
epidemiological and clinical characteristics	11
of the effects of	11
genetic and environmental factors	11
is required for the	11
adolescents and young adults	11
is protected by copyright	11
virus replication in the	11
recent studies have shown	11
encephalitis plus pulmonary edema	11
in any of the	11
in the inflamed cns	11
cd th cells in	11
acute hemorrhagic necrotizing encephalopathy	11
as a model for	11
within the cns of	11
control of west nile	11
in the cns that	11
central nervous system date	11
of the pathogenesis of	11
a wide spectrum of	11
in close proximity to	11
the differentiation of monocytes	11
did not alter the	11
may lead to the	11
following viral infection of	11
cells of the immune	11
of the underlying disease	11
despite the presence of	11
to the cns via	11
in the lewis rat	11
is cleared from the	11
as the number of	11
a pediatric patient with	11
to mg kg po	11
out to day p	11
neuronal activity in the	11
the functional significance of	11
pediatric and young adult	11
during the first days	11
the effect of the	11
over a period of	11
be present in the	11
in sjl j mice	11
graduate school of science	11
migrate to the cns	11
a child with acute	11
due to the lack	11
is not known whether	11
schwann cells in the	11
was also found to	11
reported to be associated	11
was no evidence of	11
dogs and cats with	11
in the csf and	11
hospitalized patients with coronavirus	11
t cells are present	11
during mouse hepatitis virus	11
in the development and	11
lower respiratory tract infection	11
clearance from central nervous	11
city university graduate school	11
infected with mouse hepatitis	11
is possible that the	11
the brain via the	11
in the hippocampal ca	11
approved by the institutional	11
from the gastrointestinal tract	11
in the eae model	11
member of the immunoglobulin	11
this result suggests that	11
in a pediatric patient	11
persistent infection of human	11
was injected into the	11
clinical characteristics of cases	11
animal model of multiple	11
of the number of	11
graduate school of life	11
and the severity of	11
the inflammatory response is	11
and characterization of a	11
no conflict of interest	11
article is protected by	11
in borna disease virus	11
human coronavirus oc infection	11
cell infiltration into the	11
which is characterized by	11
used for the treatment	11
as a function of	11
in the blood and	11
due to the presence	11
the risk of ms	11
fluid of a patient	11
it remains unclear whether	11
t cells are required	11
has been used in	11
diagnosis is based on	11
in learning and memory	11
mechanical ventilation may be	11
cells have been shown	11
the cns of ccr	11
of virus from the	11
it is also possible	11
by human coronavirus e	11
the cerebral cortex and	11
the cns has been	11
graft versus host disease	11
on the expression of	11
in the hippocampus and	11
relapsing experimental allergic encephalomyelitis	11
present study was to	11
is thought to play	11
and west nile virus	11
by a number of	11
research is needed to	11
mice were purchased from	11
cells in patients with	11
of demyelination induced by	11
it is unclear whether	11
this is supported by	11
results of a phase	11
cleared from the cns	11
cell lines by human	11
were obtained from the	11
of the gastrointestinal tract	11
role for sting in	11
the immune system to	11
thought to be a	11
the site of injury	11
of the immunoglobulin superfamily	11
of oligodendrocyte precursor cells	11
development of demyelinating disease	11
cns as well as	11
infection and the pathogenesis	11
this article is protected	11
in addition to this	11
activities of daily living	11
is yet to be	11
antiemetic and gastroprotectant drugs	11
schizophrenia and bipolar disorder	11
vascular cell adhesion molecule	11
is not well understood	11
the cns of tmev	11
role in the development	11
study was to investigate	11
determine the role of	11
proinflammatory cytokines and chemokines	11
can be divided into	11
in the vicinity of	11
cells in the periphery	11
as a cause of	11
cases of novel coronavirus	10
report a case of	10
the pathogenesis of demyelination	10
has an important role	10
there were no differences	10
of many of these	10
of cases of novel	10
in the cns has	10
or cd t cells	10
a mouse model for	10
of one or more	10
investigate the effect of	10
plays a key role	10
of novel coronavirus pneumonia	10
of rnase l in	10
on the development of	10
of the head and	10
the outcome of infection	10
specific cytotoxic t cells	10
to determine if the	10
associated acute hemorrhagic necrotizing	10
on the extent of	10
but not identical roles	10
of a variety of	10
murine encephalomyelitis virus infection	10
number of cd foxp	10
against west nile virus	10
redundant but not identical	10
to central nervous system	10
case of meningitis encephalitis	10
as well as for	10
in different brain regions	10
reported to occur in	10
a leading cause of	10
virus is cleared from	10
expression of major histocompatibility	10
the second most common	10
of the cerebral cortex	10
the role of chemokines	10
of t cells to	10
a number of studies	10
microglial cells in the	10
infection is associated with	10
brains of patients with	10
the treatment of multiple	10
the use of the	10
herpes simplex virus encephalitis	10
the humoral immune response	10
are required for the	10
cells present in the	10
a variety of cell	10
in the mouse central	10
key role in the	10
were significantly higher in	10
system during mouse hepatitis	10
the hpa axis and	10
cells have redundant but	10
is the first report	10
a case of a	10
has a role in	10
the cns and pns	10
of these patients had	10
new insights into the	10
a is the author	10
not identical roles in	10
the majority of patients	10
specific t cells are	10
in the prefrontal cortex	10
is induced by the	10
available under a is	10
a diagnosis of ms	10
das sarma et al	10
nervous system during experimental	10
in a child with	10
we conclude that the	10
in the frontal cortex	10
proliferation and differentiation of	10
the t cell response	10
to determine the role	10
prevention and treatment of	10
as a potential therapeutic	10
and is thought to	10
made available under a	10
doses of activated charcoal	10
clearance of the virus	10
under a is the	10
in the cytoplasm of	10
study was undertaken to	10
is similar to the	10
examined the expression of	10
that the effects of	10
in vivo effects of	10
in most of the	10
from the brain of	10
specific t cell clones	10
of the virus into	10
expression and function of	10
with middle east respiratory	10
demyelination and remyelination in	10
different regions of the	10
are associated with the	10
microglia and astrocytes in	10
we present a case	10
in the primary visual	10
from the csf of	10
the activation of microglia	10
human central nervous system	10
t cells have redundant	10
changes in the expression	10
of murine coronavirus jhm	10
it is made available	10
shown to be effective	10
have the capacity to	10
been shown to play	10
role of cytokines in	10
present in the brain	10
license it is made	10
and its role in	10
of science and technology	10
in the human cns	10
study was to determine	10
the expression of ifn	10
by human respiratory coronaviruses	10
the course of infection	10
an increased number of	10
compared to that in	10
to be capable of	10
which has been shown	10
myeloid and lymphoid cells	10
the cellular and molecular	10
in the developing rat	10
neurologic manifestations of hospitalized	10
the cns via the	10
in spinal cords of	10
nervous system during viral	10
production in the cns	10
cd t cells into	10
and activator of transcription	10
in the cns after	10
with a focus on	10
are a group of	10
cns of ms patients	10
transducer and activator of	10
t and b cells	10
in the general population	10
function within the central	10
school of life science	10
with acute respiratory distress	10
despite the fact that	10
from the brains of	10
in the ischemic brain	10
into the cns during	10
repeated doses of activated	10
can also be used	10
neuroinvasion by human respiratory	10
half of the patients	10
the cc chemokine receptor	10
median age of years	10
international license it is	10
mouse models of multiple	10
the frequency and number	10
the first year of	10
by flow cytometric analysis	10
by the activation of	10
in host defense against	10
this was associated with	10
due to lack of	10
by the administration of	10
has been studied in	10
in cultured hippocampal neurons	10
c signaling to astrocytes	10
in spinal cord injury	10
the development of ms	10
was identified as a	10
in of the patients	10
for the purpose of	10
of the gene encoding	10
is of particular interest	10
functional receptor for sars	10
hepatitis virus strain jhm	10
within the brain and	10
demyelination and axonal loss	10
in at least one	10
meningitis encephalitis associated with	10
there is evidence that	10
at a dose of	10
to understand the role	10
a negative regulator of	10
the neurons in the	10
evaluated the effects of	10
is made available under	10
it is recommended that	10
may be used to	10
the early stage of	10
i innate immune responses	10
cells in the absence	10
the treatment of patients	10
with acute disseminated encephalomyelitis	10
animal model of ms	10
neurologic alterations due to	10
performed a retrospective chart	10
underestimated opportunistic pathogens of	10
to the control of	10
a part of the	10
type i and type	10
we have previously reported	10
in the cns following	10
invasion of the cns	10
studies have been performed	10
diseases of the nervous	10
evidence to suggest that	10
g hi granulocytes in	10
the site of the	10
cd t cells specific	10
which may contribute to	10
to the conclusion that	10
depending on the type	10
signal transducer and activator	10
the permeability of the	10
in ido ko mice	10
components of the immune	10
japan we examined the	10
t cells are found	10
human coronaviruses and other	10
response within the cns	10
mice chronically infected with	10
associated with a higher	10
to respiratory virus infections	10
autoimmune encephalomyelitis in mice	10
nervous system inflammation and	10
mouse hepatitis virus infection	10
of clinical signs of	10
similar to that in	10
the hippocampal dentate gyrus	10
nervous system during mouse	10
is the presence of	10
which may result in	10
of the innate immune	10
coronaviruses and other respiratory	10
describe a case of	10
evaluate the efficacy of	10
selected with monoclonal antibodies	10
the regulation of the	10
alterations due to respiratory	10
of emesis or orogastric	10
this study suggests that	10
there is also evidence	10
due to respiratory virus	10
was not observed in	10
the expression pattern of	10
be useful in the	10
molecular profile of reactive	10
the role of ccr	10
found to be significantly	10
the cns of infected	10
receptor for sars coronavirus	10
the induction of a	10
of the respiratory tract	10
cells and b cells	10
experimental autoimmune myasthenia gravis	10
significant differences in the	10
high dose of myc	10
less is known about	10
were seen in the	10
which is involved in	10
responses within the cns	10
was closely associated with	10
is characterized by an	10
the pathogenesis of sars	10
in the early phase	10
that these cells are	10
in the level of	10
organ infection and the	10
has been found in	10
of cd b ly	10
is a major cause	10
is not associated with	10
t cell responses are	10
in any patient with	10
were purchased from the	10
signs of toxicity include	10
of primary cns tumors	10
the cns can be	10
associated with multiple sclerosis	10
also been implicated in	10
growing body of evidence	10
opportunistic pathogens of the	10
that the activation of	10
foot and mouth disease	10
after hematopoietic stem cell	10
compared to control mice	10
induction of emesis or	10
has proven to be	10
and the lack of	10
the middle cerebral artery	10
with special reference to	10
central nervous system following	10
not seem to be	10
activation and proliferation of	10
in patients with schizophrenia	10
in the identification of	10
with increased risk of	10
tokyo medical and dental	10
are considered to be	10
following infection of the	10
cats with staggering disease	10
cells in the adult	10
that they have no	10
to cd t cells	10
in the loss of	10
the age of years	10
a pathogenic role for	10
important roles in the	10
and other respiratory viruses	10
case report of a	10
patients with cns infection	10
of c bl mice	10
could be related to	10
presumed secondary hlh group	10
a retrospective analysis of	10
mouse model of multiple	10
viral persistence in the	10
as a risk factor	10
for the role of	10
cd c microglia signature	10
is also possible that	10
basic fibroblast growth factor	10
in cats and dogs	10
been reported in cats	10
in the grey matter	10
is similar to that	10
a first case of	10
of meningitis encephalitis associated	10
multiple organ infection and	10
have redundant but not	10
of the solitary tract	10
of the brain in	10
of the cc chemokine	10
this result indicates that	10
has been documented in	10
can also result in	10
cytokines and chemokines in	10
pathogens of the central	10
positive cells in the	10
in the human brain	10
in this patient population	10
blood and bone marrow	10
cells are capable of	10
the primary motor cortex	10
although it has been	10
the presence of virus	10
that the use of	10
murine hepatitis virus jhm	10
inflammatory disease of the	10
up to of patients	10
in people with ms	10
the context of the	10
accumulation in the cns	9
a common cause of	9
authors would like to	9
previous studies have shown	9
parts of the brain	9
at the protein level	9
demyelination induced by a	9
in the periphery and	9
was to investigate the	9
from the bone marrow	9
a protective role for	9
an important cause of	9
for the production of	9
been found in the	9
the nervous system of	9
breakdown of the blood	9
structure and function of	9
adult central nervous system	9
would like to thank	9
for the identification of	9
detected in the cerebrospinal	9
which is thought to	9
in our understanding of	9
in the recruitment of	9
of b cells in	9
are detected in the	9
the control of je	9
the absence of t	9
with lymphocytic choriomeningitis virus	9
the cns during acute	9
and a number of	9
more than half of	9
of cytokines in the	9
has been attributed to	9
virus origins and receptor	9
the causative agent of	9
to the onset of	9
did not appear to	9
revealed the presence of	9
to note that the	9
brain microvascular endothelial cells	9
first step in understanding	9
cell types in the	9
from day to day	9
antigenic variants of murine	9
in multiple sclerosis a	9
in small animal patients	9
detection of coronavirus in	9
cause of the disease	9
severity of the disease	9
ctl escape mutants are	9
enhanced green fluorescent protein	9
of the hpa axis	9
of antigenic variants of	9
the extent of disease	9
distribution of ace protein	9
the brains of patients	9
to the white matter	9
have been documented in	9
child with acute disseminated	9
it is essential to	9
the cellular immune response	9
to the diagnosis of	9
have not been reported	9
our data show that	9
in the area of	9
we have analyzed the	9
to evaluate the efficacy	9
the nervous system in	9
role for cd t	9
multiple sclerosis and experimental	9
similar to those of	9
were used to determine	9
was used to measure	9
cases have been reported	9
the head and neck	9
pathogenesis of murine coronavirus	9
responses in the cns	9
viral entry into the	9
from january to december	9
described in the literature	9
inflammatory cells in the	9
neural stem progenitor cells	9
of the plasma membrane	9
as well as on	9
the cns as well	9
blood and cerebrospinal fluid	9
is reported to be	9
in the pediatric age	9
the relative proportion of	9
the mouse hepatitis virus	9
statistical analysis was performed	9
were significantly reduced in	9
ct and mri features	9
per cent of cats	9
declare that they have	9
mouse hepatitis virus is	9
diseases such as ms	9
and spinal cords were	9
can be helpful in	9
not contribute to the	9
a direct effect of	9
infection in the brain	9
the adult mouse brain	9
aseptically scrub the clipped	9
from patients with multiple	9
in the gastrointestinal tract	9
play critical roles in	9
a first step in	9
of the creative commons	9
to the nervous system	9
the cns of the	9
to the accumulation of	9
viral central nervous system	9
possible central nervous system	9
similar to those in	9
cerebrospinal fluid analysis in	9
to be present in	9
diseases such as multiple	9
in an increase in	9
in glial cells and	9
the immune response and	9
in understanding sars pathogenesis	9
into the cns parenchyma	9
form of the disease	9
none of the patients	9
confirmed the presence of	9
to occur in the	9
of the lack of	9
of a cd t	9
for multiple sclerosis as	9
we have studied the	9
we have investigated the	9
in children and young	9
characterisation and epidemiology of	9
in patients with sickle	9
express mhc class ii	9
high levels of il	9
the average percentage of	9
in transgenic mice expressing	9
is often associated with	9
the molecular mechanisms underlying	9
encephalomyelitis and multiple sclerosis	9
was one of the	9
is the result of	9
disease is characterized by	9
of innate and adaptive	9
an in vitro model	9
it was possible to	9
therapy for multiple sclerosis	9
persistence in the central	9
and an increase in	9
been demonstrated to be	9
in multiple sclerosis multiple	9
by polymerase chain reaction	9
the physiological role of	9
identification and characterization of	9
astrocytes in the spinal	9
have been demonstrated in	9
can lead to a	9
a total of children	9
and epidemiology of novel	9
been reported in a	9
study the role of	9
of the basal ganglia	9
and there is no	9
years of age with	9
until the patient is	9
epidemiology of novel coronavirus	9
to be beneficial in	9
these observations indicate that	9
increased risk of developing	9
distributed under the terms	9
and activation of microglia	9
cell acute lymphoblastic leukemia	9
of multiple sclerosis and	9
examined the role of	9
inflammatory cytokines in the	9
but little is known	9
are the most frequent	9
host defense and disease	9
cd c and cd	9
suggest that activation of	9
the role of cytokines	9
is highly expressed in	9
identified in multiple sclerosis	9
the pathogenesis of viral	9
microglia are required for	9
and wrote the manuscript	9
genomic characterisation and epidemiology	9
a potential therapeutic target	9
are summarized in table	9
with a median of	9
in relapsing multiple sclerosis	9
be added to the	9
but also in the	9
bone marrow transplantation in	9
a higher proportion of	9
for the formation of	9
activated cd t cells	9
that is characterized by	9
cells are found in	9
the spleen and brain	9
implications for the pathogenesis	9
damage to the cns	9
cd t cells as	9
compared to the control	9
a consequence of the	9
a variety of different	9
the cns is a	9
novel coronavirus pneumonia in	9
clearance of infectious virus	9
the results showed that	9
bean strain of tmev	9
was not associated with	9
step in understanding sars	9
the identification of a	9
in cerebrospinal fluid of	9
of a novel coronavirus	9
been shown that the	9
to have a higher	9
in children and adolescents	9
pathogenicity of antigenic variants	9
mbp in cfa containing	9
semliki forest virus infection	9
t cells to the	9
role of the immune	9
mice were anesthetized with	9
h n influenza virus	9
has also been suggested	9
it should be noted	9
the authors declare no	9
national multiple sclerosis society	9
of coronavirus in the	9
the presence of cd	9
may be difficult to	9
and disruption of the	9
significantly decreased in the	9
in active ms lesions	9
to determine whether the	9
the creative commons attribution	9
multiple sclerosis as an	9
may also contribute to	9
immune responses in the	9
jhm selected with monoclonal	9
differentiation of monocytes into	9
mrna and protein expression	9
both acute and chronic	9
hepatitis virus jhm strain	9
the important role of	9
in the etiology of	9
inflammatory cells into the	9
characterized by the presence	9
in response to infection	9
gene expression in astrocytes	9
progenitor cells in the	9
associated with the presence	9
murine coronavirus infection of	9
administer gastroprotectant and antiemetic	9
are listed in table	9
of the patients had	9
sr t cell activation	9
the granule cell layer	9
is not able to	9
the ages of and	9
in the auditory cortex	9
to the absence of	9
cells and rantes in	9
are often associated with	9
the peripheral blood of	9
the proportion of patients	9
also can be administered	9
and contribute to the	9
relapsing remitting multiple sclerosis	9
the brain stem and	9
and middle east respiratory	9
in increased mortality and	9
of each of the	9
profile of reactive astrocytes	9
criteria for multiple sclerosis	9
scrub the clipped area	9
following infection with a	9
to study the role	9
may serve as a	9
one or more of	9
identical roles in virus	9
the extent to which	9
supported by nih grant	9
can be explained by	9
high index of suspicion	9
ability of the virus	9
the frequency of the	9
motor nucleus of the	9
of genes involved in	9
inflammatory reaction in the	9
as evidenced by the	9
coronavirus jhm selected with	9
in the brain by	9
cellular and humoral immune	9
medical and dental university	9
had at least one	9
the same level of	9
coronavirus in patients with	9
of the p gene	9
nk cells in the	9
than in the control	9
coronavirus pneumonia in wuhan	9
in patients treated with	9
in a manner that	9
at the cellular level	9
tcr transgenic mice were	9
neurons in the substantia	9
significant decrease in the	9
in cases of suspected	9
to the identification of	9
with multiple sclerosis and	9
in patients with relapsing	9
the scope of this	9
of chemokines and their	9
there appears to be	9
relapsing experimental autoimmune encephalomyelitis	9
place the patient in	9
article distributed under the	9
role of rnase l	9
in approximately of patients	9
megakaryoblastic leukemia in a	9
into the cns through	9
over the past decade	9
have previously reported that	9
both host defense and	9
in the drinking water	9
that can lead to	9
has been used as	9
immune cells in the	9
that some of the	9
a chronic demyelinating disease	9
patients with novel coronavirus	9
the most common site	9
mice persistently infected with	9
in the patients with	9
murine experimental autoimmune encephalomyelitis	9
even in the absence	9
these results indicated that	9
role of ido in	9
has also been demonstrated	9
in patients with acute	9
and spinal cord were	9
in the establishment of	9
a neurotropic murine coronavirus	9
pathogenesis of demyelination induced	9
our results demonstrate that	9
central role for cd	9
the side effects of	9
at the indicated time	9
basic protein and human	9
stem and spinal cord	9
and transforming growth factor	9
patients with progressive ms	9
low dose of myc	9
the molecular mechanisms of	9
the contribution of the	9
have also been described	9
may lead to a	9
variants of murine coronavirus	9
class ii mhc antigens	9
murine coronavirus jhm selected	9
the extent of the	9
immune cells into the	9
does not result in	9
lesions in the cns	9
for a variety of	9
origins and receptor binding	9
areas of the brain	9
activation of microglia and	9
to determine if there	9
nervous system of a	9
central nervous system infections	9
a limited number of	9
and has been shown	9
japan in order to	9
and experimental autoimmune encephalomyelitis	9
cells were resuspended in	9
regulatory t cells in	9
this is due to	9
and the patient is	9
being the most common	9
median age at diagnosis	9
there is some evidence	9
the nodes of ranvier	9
brain stem and spinal	9
can be observed in	9
has been linked to	9
and proposed neurotropic mechanisms	9
containing high dose of	9
reduced the number of	9
patient was started on	9
in a cat with	9
replication within the cns	9
in the presumed secondary	9
by the production of	9
spinal cord and optic	9
myelin basic protein peptide	9
that the increase in	9
the pediatric age group	9
to those observed in	9
is associated with an	9
a useful tool for	9
we report a case	9
to be important for	9
present results suggest that	9
virus into the cns	9
of the cns by	9
a patient with severe	9
cats were diagnosed with	9
central nervous system involvement	9
of a large number	9
the underlying cause of	9
aim of the present	9
into the spinal cord	9
persistent infection in the	9
a number of factors	9
has also been implicated	9
cd c t cell	9
expression of the chemokine	9
were included in this	9
congo hemorrhagic fever virus	9
the progression of the	9
derived from at least	9
clinical signs of disease	9
been reported to cause	9
loss of function of	9
in a wide variety	9
in a recent study	9
implications for virus origins	9
role of chemokines in	9
immune cells of the	9
and rantes in virus	9
likely to have a	9
in of the cases	9
our data demonstrate that	9
have been linked to	9
the site of infection	9
involved in the control	9
for virus origins and	9
infection by sars coronavirus	9
are one of the	9
the innate and adaptive	9
in the mammalian brain	9
authors declare that they	9