bigram

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bigram frequency
et al1443
biorxiv preprint1028
posted february1027
copyright holder1027
version posted1027
author funder1027
peer review1021
preprint https981
org licenses871
granted biorxiv860
preprintthis version818
org google675
international licenseavailable651
hsltkm https571
made available289
gene expression204
seq data194
international licenseperpetuity137
thisthis version137
cell rna131
vtwe pe129
io view129
view corchea128
pe https127
associated genes126
nucleic acids111
cell types107
sequencing data106
ssu rrna96
data set95
allowed without93
reuse allowed93
rights reserved93
without permission93
data sets92
polar set92
com document90
edit smartreference89
ofupuwd jhxsou89
jhxsou edit89
ue ofupuwd89
acids res88
ranked genes86
breast cancer85
tumor cells84
polar sets84
cell type80
machine learning79
also made74
cc license74
government work74
us government74
gene set71
deep learning70
supplementary fig66
wasthis version65
international licenseunder65
quality control64
differential expression60
fs methods59
expression data58
simulated data57
site effects56
training set56
genome sequences55
data analysis55
gene selection54
test set54
seq datasets52
link energy52
supplementary table52
gene sets51
genome biology51
rna sequencing51
genome sequencing51
cell data51
targeted gene50
rrna sequences50
gene profiling49
rrna sensor49
whole genome48
supplementary materials47
drug repurposing47
cancer cells46
supplementary figure45
lsu rrna45
seq dataset44
single cell44
hierarchical bayesian44
weight matrix44
amino acid43
cancer mutations42
universal hitting42
turnover rate42
summary statistics42
driver mutations41
reference genome40
fully automated40
mutation rate40
de bruijn40
swarm size40
least one39
resolution whole39
latent space39
wide association39
informative genes39
genes selected39
cortical thickness38
linear model38
glm egs38
integration sites37
ribosomal rna37
preprint arxiv37
automated approach37
small rna37
arxiv preprint37
expression analysis36
target set36
read counts36
total number35
real data35
cancer cell35
househam et35
sample size35
data using35
dropout events34
reference sequence34
linear regression33
dimensionality reduction33
layered polar33
specific minimizers32
differentially expressed32
yes yes32
axis denotes32
normative models32
international conference32
hitting set32
tet profile32
bi tio32
hi bi32
go terms32
preprint http31
copy number31
activation value31
hitting sets31
nitrogen content31
neural networks31
variation graph31
protein kinase30
bmc bioinformatics30
annotation matrix30
throughput sequencing29
passenger mutations29
loss function29
lower bound29
see supplementary29
ssnp totalsnp29
dimensional space29
cancer data29
computer science28
gene ontology28
acids research28
see methods28
error rate28
hpv integration28
ensg ense28
feature selection28
cell biology28
matrix factorization27
disease progression27
tangherloni et27
selected genes27
plos one27
competing interests27
single cells26
cancer genome26
realistic data26
randomly selected26
based methods26
raw data26
based approach26
human genome26
predicted genes26
compositional data26
seq hom26
optimal solutions26
nature methods26
sparc data26
de analysis25
computational biology25
publicly available25
full length25
refined bert25
synonymous motifs25
reliability ratios25
chromatin accessibility25
best ae25
neural network25
en ge24
false positive24
seq analysis24
window size24
remdesivir drc24
data structure24
imputation methods24
ig en24
local confidence24
genome biol24
ge ne24
downstream analysis24
turnover rates24
mapped reads24
running time24
generalized linear23
scale bars23
parental genome23
cancer types23
genes based23
global confidence23
peak memory23
tested dimension23
type ii23
precision medicine23
amyloid lowering23
linear models23
curation team22
informative gene22
random minimizer22
expression matrix22
chr chr22
cell communication22
drug discovery22
upper bound22
best results22
isoform quantification22
selection methods22
principal component21
learning models21
nature reviews21
target genes21
data curation21
pik ca21
specific density21
two different21
cell surface21
null distribution21
large number21
across different21
fs method21
bulk data21
pearson correlation21
figure shows21
pca followed21
false discovery21
association studies21
associated adrs20
benchmarking datasets20
different types20
gwas summary20
small number20
new data20
cna segments20
normative modeling20
random sequence20
latent variables20
sliding window20
commonly used20
methylation detection20
escherichia coli20
svm model20
sample sizes20
window sizes20
standard deviation20
enrichment analysis20
com eqnedit20
neuroimaging data20
bruijn graph20
drug interactions19
structural variant19
based figures19
nucleotide sequences19
mean ari19
genome assembly19
microscope images19
relative abundances19
downstream analyses19
cell fates19
random forest19
nat methods19
gene modules19
amino acids19
national academy19
count matrix19
excel file19
van der19
structure reconstruction19
sequencing errors19
molecular biology18
different cell18
confidence values18
transcription factor18
linkage disequilibrium18
kinase family18
allele frequency18
imaging data18
receptive field18
different strategies18
drug pair18
existing methods18
colored path18
see section18
results show18
activation values18
phase separation18
training data18
nature communications18
org https18
ground truth18
nanopore methylation18
significant structural18
relative position18
secondary structure17
tumor growth17
cell lines17
case study17
molecular docking17
classification models17
glucose metabolism17
stem cell17
gene level17
drug pairs17
profiling data17
terminal states17
fortin et17
driver genes17
input data17
cell death17
tet profiles17
dimensional representation17
specific genes17
cell populations17
false positives17
statistical analysis17
obtained using17
library sizes17
edge weights17
intervention time17
cell division17
adult gbm17
generation sequencing17
transcriptional regulatory17
wide range17
scale information17
cell cycle17
active site17
inhibitor non17
cg sssi16
gene networks16
results obtained16
genome atlas16
discovery rate16
hypothesis generation16
raloxifene log16
kia et16
new york16
clinical trials16
subject studies16
egs method16
nat biotechnol16
gene expressions16
targeted capture16
variant method16
bert model16
cancer genomes16
genome sequence16
cell library16
stem cells16
utr usage16
embryonic stem16
read mapping16
data science16
statistics datasets16
national institutes16
cell gene16
epithelial cells16
cohort sizes16
statistic value16
predicted values16
basis selection16
abide data16
calculated using16
different datasets16
rand index16
tumor types16
expression levels16
human papillomavirus16
mixture model16
kinase families16
biological processes16
gaussian process15
expression level15
convolutional layer15
nearest neighbors15
evaluation metrics15
jaccard index15
zhang et15
component analysis15
supplementary material15
feature extraction15
sparse log15
genome browser15
ra te15
reference genomes15
functional genomics15
residual permutation15
siamese network15
particle swarm15
sequence similarity15
gm cell15
batch effects15
support vector15
memory usage15
cell line15
sequence alignment15
specific gene14
gmmmd followed14
see fig14
data structures14
thickness measures14
adjusted rand14
blastn databases14
significantly higher14
correlation coefficient14
somatic mutations14
consensus sequence14
rrna sequence14
association study14
modified combat14
mutual information14
bruijn graphs14
bases away14
learning sparse14
input sequence14
label prediction14
scale bar14
kernel density14
chemical structures14
random walk14
authors declare14
totalsnp ratio14
negative binomial14
swarm optimization14
brain imaging14
original research14
regulatory network14
tumor microenvironment14
standard errors14
fastq files14
united states14
cohort target14
coding rna14
tcga breast14
plant science14
ligand type14
fold change14
interaction network14
bayesian models14
idealized data14
validation experiments14
refseq records14
missense mutations14
image data14
sequencing depth14
nature biotechnology14
even though14
integration events14
manually annotated13
functional prediction13
patient set13
siamese embedding13
sample evaluation13
drug combinations13
hierarchical clustering13
see figure13
dcnn model13
cancer mutation13
brain cancer13
protein sequence13
random variable13
hts data13
related phenotypes13
length isoform13
structures generated13
bert models13
genetic subclones13
statistic values13
adversarial clustering13
nature genetics13
per cell13
means clustering13
mutation effect13
general purpose13
fixed interval13
ovarian cancer13
si ty13
ari values13
com dcgerard13
objective function13
genomic region13
compiled ad13
relative abundance13
large datasets13
protein interaction13
functional annotation13
metadata files13
niagads genomicsdb13
chromosome arm13
systems biology13
use case13
data used13
total link13
squamous cell13
density estimation13
permit list13
analysis using13
silhouette coefficient13
generated using13
dna sequencing13
comparison models13
supplementary information13
highly expressed13
reference sequences13
performed using13
coding rnas13
malekian et13
cell migration13
reliability ratio13
monte carlo13
protein sequences13
high confidence13
latent variable13
protein kinases13
set gs13
parameter settings13
human reference13
type labels13
multiple sequence13
rna profile13
cts size13
immune response13
uniform coverage13
clustering explanation13
data projection12
mean expression12
information processing12
cell groups12
simulation study12
disease severity12
null hypothesis12
cancer res12
kb resolution12
counts distribution12
fold cross12
permutation approach12
ccf computation12
similar results12
see table12
highly similar12
peak analysis12
single nucleotide12
rrna gene12
basset model12
american journal12
peripheral blood12
combinatorial optimization12
wellcome trust12
sci rep12
original annotation12
random minimizers12
sequencing error12
feature representation12
feed forwad12
convolutional neural12
genbank indexers12
genome data12
color blindness12
expression values12
genomics data12
effect size12
different methods12
clustering methods12
software package12
ncbi taxonomy12
wide cna12
sample set12
sequence analysis12
rqvmzs cxxa12
user interface12
quinn et12
mimicking peptides12
density factor12
mononuclear cells12
pbmc datasets12
long non12
tumor stage12
zero counts12
allows us12
housekeeping genes12
processing systems12
transcript length12
negative matrix12
regulatory networks12
expressed genes12
deep neural12
known ad12
national center12
ad values12
scatac data12
snp dataset12
marburg virus12
atp binding12
learning model12
genomic data12
plant sciences12
differential utr12
mean value12
trait associations12
wolfers et12
marquand et12
data points12
poisson loss12
normative model12
expressed isoforms12
dna sequence12
previous layer12
back pocket12
capture sequencing12
first layer12
higher scc12
simulated dataset12
genome res12
effect sizes12
supplementary figures12
error rates12
big data12
cell transcriptomics12
involving atorvastatin12
interval sampling12
neighbourhood graph11
pooling layer11
corresponding author11
og en11
motif sequences11
individual cells11
mutation taster11
bert refined11
cell level11
learning algorithms11
coding dna11
reference data11
gene number11
cancer patients11
cell differentiation11
nat rev11
blood mononuclear11
mmdae followed11
path length11
computational time11
time points11
mutation data11
kinase phylogenetic11
itr og11
combination therapy11
totalsnp ratios11
author contributions11
lia na11
genes proteins11
cells killed11
independent test11
bert basic11
hot encoded11
full set11
real datasets11
biological process11
drug metab11
copy states11
exact test11
nitrogen atoms11
supplementary section11
cohort size11
pinto et11
true structure11
cell sequencing11
maximum likelihood11
ur ea11
figure legends11
fold changes11
input variables11
de novo11
expression profiles11
expression across11
clinical groups11
repeated cross11
accession number11
posterior means11
nb loss11
physiology journal11
cell hi11
quinolone resistance11
hitting time11
cell fate11
compression complexity11
colorblind safe11
posterior mean11
gov pubmed11
confidence interval11
gene identification11
hidden units11
development team11
per arm11
much lower11
time complexity11
scientific community11
intervention strategies11
markov chain11
many different11
sequence data11
rqvmzs ic11
effect prediction11
true counts11
enriched go11
amplified cells11
figure panel11
sparc dataset11
ingroup analysis11
first two11
vcf files11
data model11
rna fragments11
three different11
ld estimates11
clustering results11
decoupled motifs11
confidence coefficient11
source code11
phylogenetic group11
te ns11
neural information11
scpnmf step11
genome research11
per million11
js distance11
somatic mutation11
van den11
energy surplus11
three models11
allele frequencies11
research articles11
cell lineage11
preprint mailto11
kinase structures11
adverse drug11
leiden algorithm11
small molecules11
cell interactions11
conversion factor11
chromosome conformation11
gbm samples11
cell divisions11
ha lia11
maximum activation11
average expression11
related genes11
two types11
sparc curation11
log fc10
carnivorous plant10
profile hmm10
based approaches10
interaction networks10
reduced features10
antibiotic resistance10
prr changes10
optimization problem10
cell transcriptomic10
functional gene10
different fs10
bayesian model10
pass fail10
dna sequences10
pooling size10
transcriptome analysis10
max activation10
statistic method10
biomedical research10
stan development10
supplemental figure10
optimal cts10
attention feed10
surface receptors10
two cohorts10
three main10
predicting ad10
freely available10
transcriptomic data10
model inference10
bulk rna10
optimal polar10
genetic variation10
novel candidate10
cancer institute10
ix http10
based feature10
predictive accuracy10
web server10
empirical bayes10
rna hgnc10
two main10
binding energy10
fry pipeline10
subunit ribosomal10
drug reactions10
bmc genomics10
neck cancer10
association analysis10
positive genes10
bulk genome10
set bits10
weight genes10
natural language10
raw dataset10
cell transcriptome10
pymol sessions10
liquid phase10
composite score10
conformation capture10
default parameters10
frequency spectrum10
variation graphs10
national institute10
statistical power10
phosphorylation events10
top right10
methods section10
ddis involving10
lsu sequences10
malignant cells10
closely related10
effect removal10
bulk sequencing10
associated gene10
sparc datasets10
images show10
hong kong10
teleporting random10
supplementary note10
additional information10
expressed isoform10
lung adenocarcinoma10
reference standard10
data repository10
search results10
normal cells10
experimental data10
nalidixic acid10
human brain10
bayesian framework10
codon usage10
biomarker identification10
gene interactions10
html https10
high weight10
graph representation10
bayesian linear10
graph construction10
better performance10
clinical outcomes10
kirchoff et10
dimensional embeddings10
cell carcinoma10
kernel size10
based analysis10
previous work10
set problem10
seq studies10
tumour purity10
prediction accuracy10
rqvmzs wpg10
first step10
also provide10
broad institute10
cell growth10
analysis results10
isoform level10
lecture notes10
human embryonic9
data files9
experimental design9
recently published9
endothelial cells9
genomic features9
cell group9
chain monte9
quantification accuracy9
feature map9
data integration9
highly variable9
optimization algorithm9
edge weight9
dimension reduction9
field size9
derived rna9
imputed data9
zero mean9
normal tissue9
consensus sequences9
rare diseases9
exon count9
seq expressions9
file detailing9
normal tissues9
fail sequences9
bacterial species9
cancer research9
combat model9
candidate genes9
sequence length9
total energy9
arm level9
forwad attention9
dimensional embedding9
definition lines9
repurposing screening9
statistically significant9
command line9
knowledge graph9
model performance9
selection method9
derived fragments9
genetic evidence9
fusion points9
gene regulation9
differentially weighted9
dr af9
best hit9
web resource9
mmdvae followed9
region sample9
open source9
modeling site9
associated mirnas9
hidden layer9
lowly expressed9
lineage tree9
electron microscope9
data types9
biofilm dispersal9
colorectal cancer9
count data9
data processing9
wilcoxon test9
additional file9
boxplot showing9
subjects per9
like compounds9
plos comput9
kjin cdsll9
genes using9
factor binding9
artificial datasets9
done using9
across datasets9
pic datasets9
substrate multi9
computed using9
compatible minimizer9
com pachterlab9
niagads gwas9
unexpected features9
data submission9
tumor sample9
learning methods9
snp indel9
international journal9
bioinformatics btz9
identified using9
performance measures9
quantile empirical9
pairwise log9
simulated datasets9
bustools pipeline9
primary data9
binding region9
vcf file9
ti methods9
multiple testing9
original paper9
genetic variants9
li et9
causal genes9
neighborhood features9
convolutional layers9
feature maps9
human protein9
input sequences9
antisense rna9
linked blocks9
four different9
mutually exclusive9
average cortical9
host gene9
quinn erb9
performance metrics9
target gene9
bases apart9
real dataset9
phylogenetic groups9
computational approach9
dataset contains9
larger datasets9
probability distributions9
currently available9
type prediction9
query string9
rqvmzs chqb9
label label9
rqvmzs vqgd9
set enrichment9
jaccard distance9
clinical data9
natl acad9
data point9
total snps9
gene sequences9
repurposing drugs9
variant calling9
snp calling9
public health9
brain fgn9
sequencing technology9
mapping reads9
randomly sampled9
motif syntax9
vector contamination9
two methods9
cancer genes9
basic bert9
data sharing9
knowledge graphs9
expression omnibus9
hidden markov9
pachterlab bp9
human cancer9
tumor cell9
quantification methods9
nine data9
logistic regression9
results suggest9
pubmed https9
ad traits9
usa department9
rqvmzs fjzp9
anchor vertices9
prokaryotic ssu9
protvec embedding9
biomedical informatics9
hippocampus samples9
en si9
rnaseq data9
features selected9
frequency method9
average prr8
github repository8
tumour genome8
ravlt forgetting8
wgs filter8
peak detection8
edu https8
full list8
feature representations8
rob patro8
set condition8
statistical computing8
construction time8
rqvmzs tcb8
analysis tools8
rv ed8
allows users8
minimizer compatible8
anchor assignment8
jain et8
genomic distributions8
mrna filter8
synonymous mutations8
cell population8
superior performance8
cluster labels8
vp protein8
host response8
colored paths8
remaining genes8
human cancers8
subjects within8
expected vaf8
prostate cancer8
activation loop8
research council8
cancer detection8
birth rate8
better results8
research community8
important role8
tls ti8
surface receptor8
molecular unit8
hg systems8
case studies8
desktop application8
thioguanosine log8
exon usage8
cancer genomics8
expression profiling8
de transcripts8
may include8
main text8
count vectorizer8
six liver8
genomic dna8
compatible minimizers8
marv vp8
cancer classification8
human cohorts8
feature matrix8
rqvmzs tmou8
also provides8
human genes8
small human8
information retrieval8
zheng et8
genes whose8
line options8
different cancer8
rqvmzs uxwc8
estimated turnover8
neuroimaging initiative8
genome annotation8
differential analysis8
cell atlas8
results showed8
progenitor cells8
proton pump8
rqvmzs ueke8
low nitrogen8
type specific8
plot shows8
metagenomic samples8
future work8
semantic graph8
different time8
psi values8
pooling operation8
new england8
variant reports8
per sequence8
org abs8
functional evidence8
noncoding rnas8
ligand types8
accurately predict8
disease neuroimaging8
transcription factors8
intron signal8
rqvmzs mwfz8
rqvmzs ix8
science foundation8
kallisto alevin8
functionally related8
kinase conformations8
birnn model8
cdr score8
data availability8
reference graph8
rqvmzs bhgv8
high throughput8
size reduction8
site frequency8
selected weight8
output structure8
bulk parent8
size values8
dcgerard ldsep8
lowering intervention8
phage genomes8
mcmc simulations8
mca datasets8
methods like8
data mining8
charged contexts8
england journal8
euclidean distance8
immune cells8
level abundances8
seq reveals8
also found8
next generation8
similar cells8
mutant reads8
wild type8
uniform manifold8
clinical endpoints8
eukaryotic ssu8
project administration8
test sets8
average ari8
mbf biosciences8
analysis scripts8
liver samples8
viral integration8
read count8
los angeles8
energy deficit8
across cells8
mean abundance8
motif mixture8
new view8
fusion point8
gm datasets8
smartreference ruyzz8
significant difference8
bayesian approach8
comput biol8
small sample8
validation set8
nelfinavir drc8
anisomycin log8
different conformations8
bfimpute improves8
lung cancer8
prediction algorithms8
parameter values8
massively parallel8
target group8
default parameter8
group group8
focal amplifications8
differential exon8
random walks8
agbm sample8
semantic type8
cell technologies8
standard deviations8
individual target8
viral infection8
squared errors8
expression matrices8
density estimates8
omics data8
dataset description8
expression analyses8
research institute8
scc value8
hierarchical model8
gene pairs8
required metadata8
step ii8
neighborhood sequences8
microscope image8
absolute value8
disease maps8
com https8
se rv8
widely used8
seq pre8
coding genes8
positive rate8
artificial intelligence8
imaging flow8
refseq filter8
hpv genome8
rna ti8
relevant gene8
weighted edges8
rqvmzs df8
relevant genes8
true values8
samples using8
concomitant drug8
sampled sequences8
manifold approximation8
single administrations8
true positive8
using hierarchical8
biological variations8
models trained8
determined using8
log loss8
representation size8
short reads8
related work8
using different8
profile hmms8
cancer type8
biological function8
drug design8
tested whether8
raw nucleotide8
national cancer8
cycle genes8
one another8
residue numbering8
ad adrd8
numbering scheme8
gene lists8
repurposing screenings8
motif sequence8
vector machine8
drug targets8
three methods8
shortest path8
ad genes8
information presented8
human junction8
gene gene8
cell resolution8
immune cell8
population structure8
vanilla pca8
baseline methods8
sparc consortium8
sparc investigators8
least two7
functional enrichment7
reconstruction methods7
ann arbor7
window lists7
formal analysis7
rqvmzs pf7
srcdb pdb7
expressions among7
cell subpopulations7
differential gene7
ncbi sra7
classification performances7
kjin ujyyq7
selected based7
clinical scores7
core team7
expression counts7
gut microbiota7
human tissues7
drug safety7
rqvmzs ji7
license cc7
gsea bar7
panel ii7
tcb http7
gene annotation7
original draft7
cervical cancer7
interstitial lung7
van rooij7
rqvmzs ug7
set heuristics7
gene symbol7
ravlt learning7
personalized medicine7
family dissimilarity7
reference variation7
liquid biopsy7
ydma http7
org seurat7
niagads alzheimer7
transcript counts7
xist regulator7
high turnover7
sequencing studies7
annotated cell7
gene targets7
response variable7
unique rows7
used two7
rqvmzs bd7
matrix ws7
bayesian inference7
semantic predicates7
curation process7
recall curve7
ueke http7
transcript level7
type annotation7
proposed methods7
umi resolution7
previously proposed7
end positions7
posterior moments7
high quality7
proc natl7
gradient descent7
using normative7
related pathways7
missing data7
target interaction7
multiple mapped7
rahul satija7
sliding windows7
structure prediction7
taxonomic groups7
pcc value7
vice versa7
cancer diagnosis7
two versions7
differential splicing7
previous studies7
immune system7
cortical regions7
hard motif7
different combinations7
mqr http7
tissue type7
regulator hgnc7
eddy sr7
pediatric gbm7
log fcs7
much higher7
yv http7
will help7
mutation rates7
single path7
islet cells7
described previously7
yarza set7
alternative splicing7
bar full7
standalone program7
variable genes7
rqvmzs tqet7
nat genet7
input file7
extra trees7
kinase domain7
fungal ssu7
suffix array7
cell journal7
vql query7
nucleotide variants7
prediction performance7
every window7
glz http7
cell linage7
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