This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-006450-si5168pb | key: cord-006450-si5168pb authors: Jouneau, S.; Poineuf, J.-S.; Minjolle, S.; Tattevin, P.; Uhel, F.; Kerjouan, M.; Le Hô, H.; Desrues, B. title: Which patients should be tested for viruses on bronchoalveolar lavage fluid? |
| cord-003045-r707jl16 | In TCGA Data Using Kraken And Centrifuge Translating RNA sequencing into clinical diagnostics: opportunities and challenges Clinical relevance and public health significance of hepatitis B virus genomic variations Available online at The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data Second- generation PLINK: rising to the challenge of larger and richer datasets VirusSeq: software to identify viruses and their integration sites using next- generation sequencing of human cancer tissue Analysis of Survival Data Next- generation sequencing in clinical virology: discovery of new viruses Human endogenous retrovirus K and cancer: innocent bystander or tumorigenic accomplice? |
| cord-001985-iwfidoer | Are we missing half of the viruses in the ocean? |
| cord-011095-79ce5900 | in vitro HMPV infection influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM-1 and TLR3 expression Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children Does viral co- infection influence the severity of acute respiratory infection in children? |
| cord-018325-k69h9cc5 | A study of 25,000 illnesses in a group of Cleveland families Sites of rhinovirus recovery after point- inoculation of the upper airway Tissue remodelling in upper airways: where is the link with lower airway remodelling? |
| cord-018526-rz7id5mt | a highly efficient, lipid- mediated DNA- transfection procedure Mechanism of oligonucleotide release from cationic liposomes Cellular and molecular barriers to gene transfer by a cationic lipid Nuclear import of plasmid DNA in digitoninpermeabilized cells requires both cytoplasmic factors and specific DNA sequences Improvement of exogenous DNA nuclear importation by nuclear localization signal- bearing vectors: a promising way for non- viral gene therapy? |
| cord-006129-5rog0s98 | Are viral- encoded microRNAs mediating latent HIV-1 infection? |
| cord-006129-5rog0s98 | Current perspectives in microRNAs( miRNA) Host- virus interaction: a new role for microRNAs Silencing viral microRNA as a novel antiviral therapy? |
| cord-004501-guiy89x8 | Up to now we have concluded that current antiviral therapy has not yet achieved the ideal shape and efficiency and also that the complex biological barriers are major obstacles, but can we critically say that nanotechnology could be the identified solution? |
| cord-004501-guiy89x8 | Viral pneumonia La Revue de Médecine Interne Viral myocarditis Viral infections in type 1 diabetes mellitus- Why the β cells? |
| cord-262753-jld1ygxt | -is there a P function in vesicular stomatitis virus? |
| cord-267326-355q6k6k | H7 carrying the Stx 2 gene in sewage from different countries Characterization of metagenomes in urban aquatic compartments reveals high prevalence of clinically relevant antibiotic resistance genes in wastewaters Variation of bacterial communities with water quality in an urban tropical catchment Unhealthy landscapes: policy recommendations on land use change and infectious disease emergence Disease emergence from global climate and land use change Agricultural intensification, priming for persistence and the emergence of Nipah virus: a lethal bat- borne zoonosis Gut DNA viromes of Malawian twins discordant for severe acute malnutrition Surveillance of enteric viruses and coliphages in a tropical urban catchment Obtaining genomes from uncultivated environmental microorganisms using FACS- based single- cell genomics Viral and microbial community dynamics in four aquatic environments Occurrence of Pepper Mild Mottle Virus( PMMoV) in Groundwater from a Karst Aquifer System in the Yucatan Peninsula VirSorter: mining viral signal from microbial genomic data Evolution and diversity of the Microviridae viral family through a collection of 81 new complete genomes assembled from virome reads Metavir 2: new tools for viral metagenome comparison and assembled virome analysis Evaluating the efficacy of commercial kits for viral DNA/ RNA extraction Metagenomic characterisation of the viral community of lough neagh, the largest freshwater lake in Ireland Eukaryotic viruses in wastewater samples from the United States Relationship of microbiota and cyanobacterial secondary metabolites in planktothricoides- dominated bloom Viral metagenomics on animals as a tool for the detection of zoonoses prior to human infection? |
| cord-000346-9b6yz3f4 | ( t)~e lgt with common rate l g; and infectious cell death can be neglected( t I??). |
| cord-000346-9b6yz3f4 | ( t)~e lgt with common rate l g; and infectious cell death can be neglected( t I??). |
| cord-286219-qcx5ehnh | What has the study of the K3 and K5 viral ubiquitin E3 ligases taught us about ubiquitin- mediated receptor regulation? |
| cord-280048-b4dz1lnn | How could the problem we approached? |
| cord-281916-v6u5mr2i | He tries to give answers to a trivial scientific question: Respiratory specimens should they be « rich in cells » to ensure optimal virological molecular diagnosis? |
| cord-020235-stcrozdw | Are the sites of insertion of viral DNA specific? 2. |
| cord-020235-stcrozdw | What type of recombinatorial events occur in viral DNA integration? |
| cord-254194-962vynwk | A hazardous threat to the environment and human health? |
| cord-254194-962vynwk | Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? |
| cord-298019-gf2asni1 | The preference of tryptophan for membrane interfaces Use of hydrophobic moment plot methodology to aid the identification of oblique orientated α- helices Antimicrobial peptides and viral fusion peptides: how different they are? |
| cord-307817-2vy28i4m | Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity Structure- activity relationship studies on clinically relevant HIV-1 NNRTIs Non- nucleoside inhibitors of the HCV NS5B polymerase: progress in the discovery and development of novel agents for the treatment of HCV infections Next- generation integrase inhibitors: where to after raltegravir? |
| cord-272655-qeojdpez | : What is the best therapy for influenza and other viral causes of community- acquired pneumonia? |
| cord-272655-qeojdpez | What is the role of respiratory viruses in community- acquired pneumonia? |
| cord-009577-29u7pdpk | By taking genomic segments from neuroinvasive and noninvasive strains, one can ask the question: which genome segment is responsible for the ability to penetrate the CNS? |
| cord-009577-29u7pdpk | Enhancer elements Continuous cultures of fused cells secreting antibodies of predetermined specificity Moloney sarcoma virus Enhancement of the infectivity of influenza A and B viruses by proteolytic cleavage of the hemagglutinin polypeptide Is the acetylcholine receptor a rabies virus receptor? |
| cord-009577-29u7pdpk | Tyler and collaborators exploited this fact to test reassortants of type 1 and type 3 viruses and again ask the question: which gene segmeiit accounts for the different patterns of spread in these two strains? |
| cord-308126-wpxhk0pf | The economic burden and symptom manifestations of chronic rhinosinusitis First line management of sinusitis: a national problem? |
| cord-292335-al6v3b9x | The problem with cephalosporins Does antibiotic exposure increase the risk of methicillin- resistant Staphylococcus aureus( MRSA) isolation? |
| cord-294592-zwvr57a0 | A new key player in virus- host interactions? |
| cord-270670-cubh9jxc | A principle of natural self- organization Genetic lesions associated with Muller's ratchet in an RNA virus Molecular biology, pathogenesis, and control of animal viruses Lethal mutagens: broad- spectrum antivirals with limited potential for development of resistance? |
| cord-270670-cubh9jxc | Can studies on complexity be of use to infectious diseases? |
| cord-305195-e41yfo89 | With these evolving technologies in mind, it is timely to ask: Is the world able to control viral diseases more effectively? |
| cord-307354-dkwcheu0 | virion host shutoff RNase is enabled by pUL47 and an embedded nuclear export signal and defines the sites of degradation of AU- rich and stable cellular mRNAs Viral phosphodiesterases that antagonize doublestranded RNA signaling to RNase L by degrading 2- 5A Human genome- wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis Herpes simplex virus virion host shutoff protein: immune evasion mediated by a viral RNase? |
| cord-314024-n6l2804j | A Trial of Lopinavir- Ritonavir in Adults Hospitalized 206 with Severe Covid-19 Acute bacterial or viral infection- What's the difference? |
| cord-286843-8qh1pblc | The immunology of influenza virusassociated bacterial pneumonia Integrated clinical, pathologic, Virologic, and transcriptomic analysis of H5N1 influenza virus- induced viral pneumonia in the rhesus macaque Kinetics of coinfection with influenza a virus and Streptococcus pneumoniae Etiology of severe communityacquired pneumonia during the 2013 hajj- part of the MERS- CoV surveillance program Clinical and molecular characterization of rhinoviruses a, B, and C in adult patients with pneumonia Human rhinoviruses and severe respiratory infections: is it possible to identify at- risk patients early? |
| cord-286843-8qh1pblc | The past decade in bench research into pulmonary infectious diseases: what do clinicians need to know? |
| cord-302111-kg0dmgq0 | cause recurrent wheeze of early childhood and asthma? |
| cord-318751-4v2tl0gi | Secondgeneration inhibitors of the cellular ATPase DDX3 with improved anti- HIV activity: synthesis, structure- activity relationship analysis, cytotoxicity studies, and target validation Viruses and the human DEAD- box helicase DDX3: inhibition or exploitation? |
| cord-274080-884x48on | Molecular mechanism of divalentmetal- induced activation of NS3 helicase and insights into Zika virus inhibitor design HCV infection by cell- to- cell transmission: choice or necessity? |
| cord-274080-884x48on | Novel ESCRT functions in cell biology: spiraling out of control? |
| cord-287459-k9x3z2h1 | Covid-19: What do we know so far about a vaccine? |
| cord-287459-k9x3z2h1 | The regulation of hepatic fatty acid synthesis and partitioning: The effect of nutritional state Regulation of cholesterol and fatty acid synthesis Regulation of fatty acid and cholesterol synthesis: Co- operation or competition? |
| cord-306921-3afgpunj | -what is the evidence for causation? |
| cord-018058-n3majqes | Since When Have We Known of Viruses?" |
| cord-018058-n3majqes | What Is the Importance of the Henle- Koch Postulates? |
| cord-018058-n3majqes | What Is the Interrelationship Between Virus Research, Cancer Research, Neurobiology and Immunology? |
| cord-281844-c0uhcatg | Role of respiratory viruses and allergen sensitization Associations between environmental exposures and asthma control and exacerbations in young children: a systematic review Smoke- free legislation and hospitalizations for childhood asthma Personal exposure to nitrogen dioxide( NO 2) and the severity of virus- induced asthma in children Health effects of indoor nitrogen dioxide and passive smoking on urban asthmatic children Environmental tobacco smoke exposure and nocturnal symptoms among inner- city children with asthma Results of a home- based environmental intervention among urban children with asthma Guidelines reduce X- ray and blood gas utilization in acute asthma Basic Research on virus- induced asthma exacerbation: inhibition of inflammatory chemokine expression by fluticasone propionate Respiratory viral infections in children with asthma: do they matter and can we prevent them? |
| cord-281844-c0uhcatg | key: cord-281844-c0uhcatg authors: Costa, Lusmaia D.C.; Costa, Paulo Sucasas; Camargos, Paulo A.M. title: Exacerbation of asthma and airway infection: is the virus the villain? |
| cord-319675-mwy3t1ny | Two fatal cases of adenovirus- related illness in previously healthy young adults- Illinois Severe adenovirus pneumonia in immunocompetent adults: a case report and review of the literature Severe pneumonia due to adenovirus serotype 14: a new respiratory threat? |
| cord-292416-3hhi4wps | The next outbreak? |
| cord-292416-3hhi4wps | what can they teach us about the severe acute respiratory syndrome? |
| cord-318749-k91oku7h | How should we think about the ribosome? |
| cord-312332-rwmuucsp | Do cellular RBPs participate in viral particle assembly? |
| cord-286137-4cbh3u3z | Could nutrition also actively shape how viruses evolve? |
| cord-286137-4cbh3u3z | So, do viruses harboring higher genetic diversity initially fare better in establishing an infection and displaying virulent phenotypes? |
| cord-323404-3mw4q7m3 | strain A59 is released from opposite sides of different epithelial cell types Antigenic and molecular analyses reveal that the equine rotavirus strain H-1 is closely related to porcine, but not equine, rotaviruses: interspecies transmission from pigs to horses? |
| cord-262585-5vjqrnwh | For example, can some viral peptides be useful as adjuvants? |
| cord-262585-5vjqrnwh | What specific constraints limit SLiM evolvability? |
| cord-262585-5vjqrnwh | in the design of vaccines and therapies to promote global health? |
| cord-325230-3kg4oe4g | another mechanism for host protein synthesis shutoff? |
| cord-103460-5thh6syt | A comparison of bats and 808 rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-103460-5thh6syt | Are bats really'special'as viral reservoirs? |
| cord-103460-5thh6syt | what we know and need to know Mass extinctions, biodiversity and mitochon-813 drial function: are bats'special'as reservoirs for emerging viruses? |
| cord-258685-ayek8zbo | Should we try to alleviate immunosenescence and inflammaging- why, how and to what extent? |
| cord-258685-ayek8zbo | The anti- tumor effect of allogeneic bone marrow/ stem cell transplant without graft vs. host disease toxicity and without a matched donor requirement? |
| cord-258685-ayek8zbo | over Ready to submit your research? |
| cord-309642-wwaa6ls0 | Some aspects of pulmonary defence Retroviral transforming genes in normal cells? |
| cord-309642-wwaa6ls0 | The immunopathogenesis of dengue haemorrhagic fever Virally induced alterations in cellular permeability: A basis of cellular and physiological damage? |
| cord-317277-rr9zue4l | They might be giants: does syncytium formation sink or spread HIV infection? |
| cord-317277-rr9zue4l | Viral extracellular biofilms: a novel spreading trick of viruses? |
| cord-297960-4x1j0iqg | : can we ever expect the unexpected? |
| cord-297960-4x1j0iqg | How Do intrinsically disordered viral proteins hijack the cell? |
| cord-330684-3hxau5vt | Host defense, viruses and apoptosis Enter the kill zone: initiation of death signaling during virus entry Cell death in the host response to infection Immunogenic and tolerogenic cell death Viral subversion of immunogenic cell death Viral control of mitochondrial apoptosis A time to kill: viral manipulation of the cell death program To kill or be killed: how viruses interact with the cell death machinery Caspases in apoptosis and beyond Human caspases: activation, specificity, and regulation Caspase activation during virus infection: more than just the kiss of death? |
| cord-334127-wjf8t8vp | Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource Is there any value to hepatitis B virus genotype analysis? |
| cord-314560-rswa5zdn | The role of a mutant CCR5 allele in HIV-1 transmission and disease progression Long- term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti- HIV shRNA, anti- CCR5 ribozyme, and a nucleolar- localizing TAR decoy Antibody mediated in vivo delivery of small interfering RNAs via cell- surface receptors Inhibition of HIV-1 by lentiviral vectortransduced siRNAs in T lymphocytes differentiated in SCID- hu mice and CD34 C progenitor cell- derived macrophages Lentiviral vector delivery of siRNA and shRNA encoding genes into cultured and primary hematopoietic cells Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer Plasmacytoid dendritic cells in immunity Sequence- dependent stimulation of the mammalian innate immune response by synthetic siRNA Noise amidst the silence: offtarget effects of siRNAs? |
| cord-314560-rswa5zdn | cord-314560-rswa5zdn authors: Manjunath, N.; Kumar, Priti; Lee, Sang Kyung; Shankar, Premlata title: Interfering antiviral immunity: application, subversion, hope? |
| cord-328259-3g4klpyg | https://www.mg-rast.org/linkin.cgi? |
| cord-271495-5906wju4 | Are SARS superspreaders cloud adults? |
| cord-271495-5906wju4 | cord-271495- 5906wju4 authors: Beldomenico, Pablo M. title: Do superspreaders generate new superspreaders? |
| cord-271495-5906wju4 | vicious circles? |
| cord-022156-mm8en4os | : are we where we need to be? |
| cord-022156-mm8en4os | Bacterial tracheitis reexamined: is there a less severe manifestation? |
| cord-022156-mm8en4os | Ten- year experience with IPPB in the treatment of acute laryngotracheobronchitis Racemic epinephrine in the treatment of laryngotracheitis: can we identify children for outpatient therapy? |
| cord-022156-mm8en4os | a varied entity Is bacterial tracheitis changing? |
| cord-320015-lbr2q4qh | Characterization of primary and memory CD8 T- cell responses against ranavirus( FV3) in Xenopus laevis Xenopus laevis: A possible vector of Ranavirus infection? |
| cord-320015-lbr2q4qh | a purine nucleoside phosphorylase Genomic sequence of a ranavirus( family Iridoviridae) associated with salamander mortalities in North America Poxviruses: past, present, and future How similar are poxviruses? |
| cord-330200-l6bnxi40 | A novel coronavirus from patients with pneumonia in China Emergence of novel coronavirus and COVID-19: whether to stay or die out? |
| cord-329710-vqorb6j7 | Why are lopinavir and ritonavir effective against the newly emerged coronavirus 2019? |
| cord-337673-1nau263l | nature abhors a double- strand Role for a bidentate ribonuclease in the initiation step of RNA interference RNA interference is mediated by 21-and 22-nucleotide RNAs Argonaute2, a link between genetic and biochemical analyses of RNAi Single- stranded antisense siRNAs guide target RNA cleavage in RNAi Transgenes and gene suppression: telling us something new? |
| cord-331673-xv1tcugl | Far from Clinical Use? |
| cord-331673-xv1tcugl | Hypericin- Loaded Graphene Oxide Protects Ducks against a Novel Duck Reovirus Graphene- Based"Hot Plate"for the Capture and Destruction of the Herpes Simplex Virus Type 1 Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias? |
| cord-307813-elom30nx | A decoy peptide that disrupts TIRAP recruitment to TLRs is protective in a murine model of influenza Novel strategies for targeting innate immune responses to influenza Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in toll- like receptor 3 knockout mice Inhibition of toll- like receptor signaling as a promising therapy for inflammatory diseases: a journey from molecular to nano therapeutics Small- molecule inhibitors of the TLR3/ dsRNA complex Radix isatidis polysaccharides inhibit influenza a virus and influenza A virus- induced inflammation via suppression of Host TLR3 signaling in vitro Novel effect of methionine enkephalin against influenza A virus infection through inhibiting TLR7-MyD88-TRAF6-NF- kappaB p65 signaling pathway Influenza virus and glycemic variability in diabetes: a killer combination? |
| cord-307813-elom30nx | Innate lymphoid cells in asthma: will they take your breath away? |
| cord-307813-elom30nx | a mechanism for the unusual severity of human disease? |
| cord-353297-jizitnfl | Did bioweapons test cause a deadly smallpox outbreak? |
| cord-014397-7b88ycv8 | A sialoglycopeptide from human erythrocytes with receptor- like properties for encephalomyocarditis and influenza viruses Resistance in transgenic tobacco plants expressing a nonstructural gene sequence of tobacco mosaic virus is a consequence of markedly reduced virus replication Does the beta- andrenergic factor receptor function as reovirus receptor? |
| cord-014397-7b88ycv8 | Determinants essential for the transmissible gastroenteritis virus receptor interaction reside within a domain of aminopeptidase N that is distinct from the enzymatic site Molecular characterization of gene- for- gene systems in plant fungus interactions and the application of avirulence genes in control of plant pathogens Risk assessment: do we let history repeat itself? |
| cord-014397-7b88ycv8 | Plant viral resistance Will transgenic crops generate new viruses and new diseases? |
| cord-014397-7b88ycv8 | The mammalian cell- virus relationship Attachment of poliovirus to cultivated cells of primate and nonprimate origin Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily Binding to sialic acids is not an essential step for entry of animal rotaviruses to epithelial cells in culture Genetic exchange between bacteriophage T4 and filamentous fungi? |
| cord-014397-7b88ycv8 | Why did certain mechanisms develop and others not? |
| cord-022439-8wy7rpqv | Antibody- all relevant epitopes recognized? |
| cord-022439-8wy7rpqv | Interferon induction in interstitial cells? |
| cord-022439-8wy7rpqv | Molecular mimicry: frequency of reac tivity of monoclonal antiviral antibodies with normal tissues Monoclonal antibody to coxsackievirus B reacts with myocardium Polymyositis and molecular mimicry: a mechanism of auto immunity On the use of se quence homologies to predict protein structure: Identical pentapeptides can have completely different conformations Which structural features determine protein antigenicity? |
| cord-022439-8wy7rpqv | Receptor availability? |
| cord-022439-8wy7rpqv | la antigens? |
| cord-337361-salby0fu | How do viruses interact with stress- associated RNA granules? |
| cord-337361-salby0fu | Why do RNA viruses recombine? |
| cord-269194-b1wlr3t7 | Are treatment options available? |
| cord-269194-b1wlr3t7 | For how long will the patient need to be on therapy? |
| cord-269194-b1wlr3t7 | Simple amplification- based assay: A nucleic acid- based point- of- care platform for HIV-1 testing HIV-1 viral load blips are of limited clinical significance HIV cure and eradication: How will we get from the laboratory to effective clinical trials? |
| cord-269194-b1wlr3t7 | Transducers Quantitation of mRNA by the polymerase chain reaction Prehistoric eye disease( trachoma?) |
| cord-269194-b1wlr3t7 | What treatment regimen should be prescribed? |
| cord-349358-leicos9j | Again, as with other drugs in development against HIV infection, we are confronted with the following major questions: what are the potential side effects from such an approach, and what would be the therapeutic dose window? |
| cord-349358-leicos9j | In other words, what would be the preferred delivery system to use in animals and later on in humans? |
| cord-317037-1qydcc5e | : Are they close relatives? |
| cord-317037-1qydcc5e | A novel mechanism of generating extracellular vesicles during apoptosis via a beads- on- a- string membrane structure Plasma Membrane Lipid Domains as Platforms for Vesicle Biogenesis and Shedding? |
| cord-317037-1qydcc5e | Premises for the Therapeutic Use Mesenchymal stromal cells and their secreted extracellular vesicles as therapeutic tools for COVID-19 pneumonia? |
| cord-317037-1qydcc5e | The chicken or the egg? |
| cord-016475-7ldxvbpz | Are we ready for pandemic influenza? |
| cord-016475-7ldxvbpz | Attenuated Or Inactivated Influenza- A Virus- Vaccine Caspases: the executioners of apoptosis Protein kinases-- the major drug targets of the twenty- first century? |
| cord-016475-7ldxvbpz | GG167 Influenza Study Group Safety and efficacy of the neuraminidase inhibitor GG167 in experimental human influenza Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment MAPK- regulated transcription: a continuously variable gene switch? |
| cord-016475-7ldxvbpz | In vitro characterization of A-315675, a highly potent inhibitor of A and B strain influenza virus neuraminidases and influenza virus replication Novel generations of influenza vaccines Cold- adapted live attenuated influenza vaccines developed in Russia: can they contribute to meeting the needs for influenza control in other countries? |
| cord-016475-7ldxvbpz | Influenza: emergence and control Preparation of a standardized, efficacious agricultural H5N3 vaccine by reverse genetics Effective construction of DNA vaccines against variable influenza genes by homologous recombination Influenza virus induction of apoptosis by intrinsic and extrinsic mechanisms Influenza virus- induced AP-1-dependent gene expression requires activation of the JNK signaling pathway Influenza- virus- induced signaling cascades: targets for antiviral therapy? |
| cord-016475-7ldxvbpz | The influenza B virus nonstructural NS1 protein is essential for efficient viral growth and antagonizes beta interferon induction A pandemic warning? |
| cord-346916-jj4l9ydl | : what have we learned and where are we headed? |
| cord-346916-jj4l9ydl | Toll- like receptor 3 in viral pathogenesis: friend or foe? |
| cord-353554-98uzivsk | Why did the virus select the proteins with multiple interaction partners as receptors? |
| cord-353554-98uzivsk | what's the relationship between glycosylation and viral receptor selection? |
| cord-015893-e0fofgxq | And what causes my asthma suddenly to become worse? ” |
| cord-015893-e0fofgxq | And what causes my asthma suddenly to become worse?" |
| cord-015893-e0fofgxq | The role of rhinovirus in asthma exacerbations Expresssion of intercellular adhesion molecule-1( ICAM-1) in nasal epithelial cells of atopic subjects: a mechanism for increased rhinovirus infection? |
| cord-015893-e0fofgxq | clinical asthma phenotypes Infectious asthma: a reemerging clinical entity? |
| cord-015893-e0fofgxq | e0fofgxq Health care providers who treat patients with respiratory disease are often asked by their patients, “ What caused my asthma? |
| cord-015893-e0fofgxq | iNtroDuctioN Health care providers who treat patients with respiratory disease are often asked by their patients,"What caused my asthma? |
| cord-015893-e0fofgxq | it initiate asthma and does it trigger asthma? |
| cord-325750-x7jpsnxg | , Mandrillus leucophaeus Isolation of a cDNA from the virus responsible for enterically transmitted non- A, non- B hepatitis Quantitative monitoring of gene expression patterns with a complementary DNA microarray Viral discovery and sequence recovery using DNA microarrays Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant Prostate cancer: XMRV-contaminant, not cause? |
| cord-325750-x7jpsnxg | For example, how far has this new viral metagenomics discipline evolved in its first decade? |
| cord-325750-x7jpsnxg | The discovery of the poliovirus Smallpox and Its Eradication The Greatest Killer-Smallpox in History Discovery of the first virus, the tobacco mosaic virus: 1892 or 1898? |
| cord-325750-x7jpsnxg | What has been learned so far that can be applied to viral discovery and the forecasting of future viral outbreaks? |
| cord-021146-wdnnjlcw | And which consequences will the Covid-19 pandemic have in regards to the environment, surveillance, worlwide rise of fascism, democracy? |
| cord-021146-wdnnjlcw | How many indirect victims will the Covid-19 pandemic create? |
| cord-021146-wdnnjlcw | However, what happens to people who have not been infected by Covid-19 but have lost their jobs, can not pay their mortgages, or have become homeless due to economic slowdown? |
| cord-021146-wdnnjlcw | In our context of advanced global capitalism, what should be done to spread the burden of the pandemic at least a bit more equally? |
| cord-021146-wdnnjlcw | What happens to the most vulnerable members of the society-children, elderly, disabled, those with mental issues? |
| cord-021146-wdnnjlcw | address Coronavirus and the clash of civilizations Viral evolution: primordial cellular origins and late adaptation to parasitism Viral modernity? |
| cord-291063-de7v4e5s | Are viral- encoded microRNAs mediating latent HIV-1 infection? |
| cord-291063-de7v4e5s | LNA- mediated microRNA silencing in non- human primates Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses Silencing of microRNAs in vivo with'antagomirs Specificity, duplex degradation and subcellular localization of antagomirs Regulation of microRNA by antagomirs: a new class of pharmacological antagonists for the specific regulation of gene function? |
| cord-291063-de7v4e5s | Silencing Viral MicroRNA as a Novel Antiviral Therapy? |
| cord-291063-de7v4e5s | The properties and functions of virus encoded microRNA, siRNA, and other small noncoding RNAs Small RNAs: delivering the future Lentivirusmediated antagomir expression for specific inhibition of miRNA function Antisense, RNAi, and gene silencing strategies for therapy: mission possible or impossible? |
| cord-291063-de7v4e5s | ammunition to target miRNAs implicated in human disease? |
| cord-259233-smmhhroe | Cold Spring Harbor Perspectives in Late budding domains and host proteins in enveloped virus release Mechanisms for enveloped virus budding: can some viruses do without an ESCRT? |
| cord-259233-smmhhroe | Could CD4 capture by CD8+ T cells play a role in HIV spreading? |
| cord-259233-smmhhroe | Exosomes and retroviruses: the chicken or the egg? |
| cord-259233-smmhhroe | Herpesviruses remodel host membranes for virus egress Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses ORF1a- encoded replicase subunits are involved in the membrane association of the arterivirus replication complex Kunjin virus: an Australian variant of West Nile? |
| cord-259233-smmhhroe | Trojan exosomes riding the Trojan horse? |
| cord-259233-smmhhroe | Virus assembly and plasma membrane domains: which came first? |
| cord-259233-smmhhroe | and what is its purpose? |
| cord-270294-g95skuik | : what's new with respiratory viruses? |
| cord-270294-g95skuik | A study by Marcos et al.!? |
| cord-270294-g95skuik | Most published studies's? |
| cord-270294-g95skuik | Nucleic acid amplification tests for detection and analysis of respiratory viruses: the future for diagnostics? |
| cord-270294-g95skuik | One study.!? |
| cord-270294-g95skuik | To date, there have been few studies, 5, 7,[ 9][ 10][ 11] 16, 17 reported in patients with pneumonia using NATs to detect viral infection, and these studies have either not included clinical data 7.9.11 or have not tested for all potentially important respiratory viruses in a comprehensive manner.lv-!? |
| cord-270294-g95skuik | To our knowledge, only two previous etiology studiess-!? |
| cord-332632-u2ud0vmq | : what resistance and tolerance can teach us about treating infectious diseases Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice Immune responses against classical swine fever virus: between ignorance and lunacy, Front Innate immunity: quo vadis? |
| cord-332632-u2ud0vmq | TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus Nucleic acids and endosomal pattern recognition: how to tell friend from foe? |
| cord-332632-u2ud0vmq | What can pestiviral endonucleases teach us about innate immunotolerance? |
| cord-332632-u2ud0vmq | von der Biologie zur Bekämpfung Pestivirus control programs: how far have we come and where are we going? |
| cord-355872-z6vsjmxn | : can we ever expect the unexpected? |
| cord-355872-z6vsjmxn | A strategy to estimate unknown viral diversity in mammals Public health threat of new, reemerging, and neglected zoonoses in the industrialized world Viral metagenomics on animals as a tool for the detection of zoonoses prior to human infection? |
| cord-355872-z6vsjmxn | How does one predict when and where a pathogen will jump a species barrier or emerge into a new population that could rapidly spread into new geographic regions? |
| cord-306424-gf0bglm0 | IFN- lambda( IFN-??) is expressed in a tissue- dependent fashion and primarily acts on epithelial cells in vivo Severe acute respiratory syndrome- related coronavirus is inhibited by interferon- alpha Interferon- beta and interferongamma synergistically inhibit the replication of severe acute respiratory syndrome- associated coronavirus( SARS- CoV) Evaluation of immunomodulators, interferons and known in vitro SARS- CoV inhibitors for inhibition of SARS- CoV replication in BALB/ c mice Single- dose intranasal administration with mDEF201 |
| cord-306424-gf0bglm0 | IFN- lambda( IFN-??) is expressed in a tissue- dependent fashion and primarily acts on epithelial cells in vivo Severe acute respiratory syndrome- related coronavirus is inhibited by interferon- alpha Interferon- beta and interferongamma synergistically inhibit the replication of severe acute respiratory syndrome- associated coronavirus( SARS- CoV) Evaluation of immunomodulators, interferons and known in vitro SARS- CoV inhibitors for inhibition of SARS- CoV replication in BALB/ c mice Single- dose intranasal administration with mDEF201 |
| cord-306424-gf0bglm0 | Membranous replication factories induced by plus- strand RNA viruses Does form meet function in the coronavirus replicative organelle? |
| cord-306424-gf0bglm0 | interferon induction Cardif is an adaptor protein in the RIG- I antiviral pathway and is targeted by hepatitis C virus Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF VISA is an adapter protein required for virus- triggered IFN-?.?. |
| cord-306424-gf0bglm0 | interferon induction Cardif is an adaptor protein in the RIG- I antiviral pathway and is targeted by hepatitis C virus Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF VISA is an adapter protein required for virus- triggered IFN-?.?. |
| cord-306424-gf0bglm0 | what and how? |
| cord-023143-fcno330z | *? |
| cord-023143-fcno330z | , Cara Wilsont, Kelledy Mansons, Michael Wyands, Bruce Walker?, Ronald C. Desrosiers |
| cord-023143-fcno330z | However, productive virus replication is minimized by antiviral CD8 T cells which suppress( kill?) |
| cord-023143-fcno330z | PrP genes were used to demonstrate that the"specie9 bank?' |
| cord-023143-fcno330z | The interferons( IFNs) a n? a family of cytokines whose functions include the protection of cells against viral infection. |
| cord-023143-fcno330z | Thes? |
| cord-023143-fcno330z | ofthe influenza HA protein from this second promoter in baby hamster kidney( BHK) cells was approximately 50?? |
| cord-023143-fcno330z | ofthe influenza HA protein from this second promoter in baby hamster kidney( BHK) cells was approximately 50?? |
| cord-340423-f8ab7413 | How does the genome structure and lifestyle of a virus affect its population variation? |
| cord-340423-f8ab7413 | Nonreplicative homologous RNA recombination: promiscuous joining of RNA pieces? |
| cord-340423-f8ab7413 | The question that arises is: How do RNA viruses withstand mutation? |
| cord-340423-f8ab7413 | Why do RNA viruses recombine? |
| cord-320713-b37c8aye | How do microRNAs regulate gene expression? |
| cord-320713-b37c8aye | How does influenza virus regulate gene expression at the level of mRNA translation? |
| cord-320713-b37c8aye | What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame? |
| cord-320713-b37c8aye | another mechanism for host protein synthesis shutoff? |
| cord-320713-b37c8aye | is the eIF4E cap- binding factor required for viral mRNA translation? |
| cord-320713-b37c8aye | mRNAs Does phosphorylation of the cap- binding protein eIF4E play a role in translation initiation? |
| cord-016499-5iqpl23p | Antimicrobials for acute otitis media? |
| cord-016499-5iqpl23p | Do rhinoviruses reduce the probability of viral codetection during acute respiratory tract infections? |
| cord-016499-5iqpl23p | Human major group rhinoviruses downmodulate the accessory function of monocytes by inducing IL-10 Rhinovirus- induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness Nasal- secretion leukocyte populations determined by fl ow cytometry during acute rhinovirus infection Expression of intercellular adhesion molecule-1( ICAM-1) in nasal epithelial cells of atopic subjects: a mechanism for increased rhinovirus infection? |
| cord-016499-5iqpl23p | Infl uenza vaccination in the prevention of acute otitis media in children Effi cacy of a pneumococcal conjugate vaccine against acute otitis media Rhinovirus in acute otitis media Temporal relationships between colds, upper respiratory viruses detected by polymerase chain reaction, and otitis media in young children followed through a typical cold season Presence of viral nucleic acids in the middle ear: acute otitis media pathogen or bystander? |
| cord-016499-5iqpl23p | Is acute otitis media a treatable disease? |
| cord-016499-5iqpl23p | So, what do cohort studies, supported by comprehensive PCR- based testing, tell us about asymptomatic virus infections? |
| cord-016499-5iqpl23p | The cold case: Are rhinoviruses perfectly adapted pathogens? |
| cord-016499-5iqpl23p | The common cold: control? |
| cord-016499-5iqpl23p | The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis Rhinovirus infections of children in hospital; isolation of three possibly new rhinovirus serotypes Do rhinoviruses reduce the probability of viral co- detection during acute respiratory tract infections? |
| cord-016499-5iqpl23p | This feature raises an issue: did the use of older subjects in many common cold studies underplay the pathogenic potential of the HRVs because protective or partially cross- protective antibodies moderated the impact of infection? |
| cord-016499-5iqpl23p | human rhinovirus type 17 Antigenic variation of rhinovirus type 22 Isolation of rhinovirus intertypes related to either rhinoviruses 12 and 78 or 36 and 58 Is a rhinovirus vaccine possible? |
| cord-018430-u3k8pds6 | ( Fieldler's?) treated with ACTH; report of a case in a 7-year- old boy with improvement Acute aseptic myocarditis: corticosteroid therapy Dilated cardiomyopathy caused by acute myocarditis in pediatric patients: evolution of myocardial damage in a group of potential heart transplant candidates Immunosuppressive therapy in experimental and clinical myocarditis Lack of objective improvement in ventricular systolic function in patients with myocarditis treated with azathioprine and prednisone Treatment of chronic myocarditis with corticosteroids Gamma- globulin treatment of acute myocarditis in the pediatric population Long- term follow up of patients with dilated heart muscle disease treated with human leucocytic interferon alpha or thymic hormones initial results |
| cord-018430-u3k8pds6 | A minor villain? |
| cord-018430-u3k8pds6 | Anti- idiotype- pulsed B cells in the induction and expression of autoimmune myocarditis Viral myocarditis leading to cardiomyopathy: do cytokines contribute to pathogenesis? |
| cord-018430-u3k8pds6 | High- dose intravenous gammaglobulin for Kawasaki disease Giant cell myocarditis: evidence for the macrophage origin of the giant cells Giant cell myocarditis: an autoimmune disease? |
| cord-018430-u3k8pds6 | Potential role of sarcolemmal induction of the MHC and ICAM-1 in the detection of autoimmune mediated myocyte injury Should endomyocardial biopsy be performed for detection of myocarditis? |
| cord-018430-u3k8pds6 | The difficulty of diagnosing and treating myocarditis was recognized by Senac 1 in 1772:"The inflammation of the heart is difficult to diagnose and when we have diagnosed it, can we then treat it better?" |
| cord-018430-u3k8pds6 | The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease Viral myocarditis: receptors that bridge the cardiovascular with the immune system? |
| cord-018430-u3k8pds6 | Validation study and meta- analysis of published HLA association studies Anti- idiotypic antibodies to a polyomavirus monoclonal antibody recognize cell surface components of mouse kidney cells and prevent polyomavirus infection Autoanti- idiotype: a basis for autoimmunity and a strategy for antireceptor antibodies Naturally occurring anti- idiotypic antibodies- mechanisms for autoimmunity and immunoregulation? |
| cord-018430-u3k8pds6 | What lessons can be learned from animal model studies in viral heart disease? |
| cord-018430-u3k8pds6 | a link between myocarditis and dilated cardiomyopathy? |
| cord-018430-u3k8pds6 | first report of disease recurrence in the transplanted heart Giant cell myocarditis- like appearance after transplantation: an atypical manifestation of rejection? |
| cord-287711-gw8mgg4m | ( 2004) illustrated the ability of Al 3? |
| cord-287711-gw8mgg4m | (, 2007a proposed a variation in the method that consisted in pre- conditioning the filter with Al 3? ions. |
| cord-287711-gw8mgg4m | Despite these promising data, the two viradel methods based on electronegative filters( i.e., addition of MgCl 2 to water samples or filter coating with Al 3? |
| cord-287711-gw8mgg4m | Hence, most tests reported so far for virus concentration from water samples using cellulose ester filters( essentially HA filters) have been performed after addition of multivalent cations( mainly Mg 2?) to the water samples with or without pH adjustment to an acidic level. |
| cord-287711-gw8mgg4m | Self assembled into nanosheets to yield''mille feuille''structures, they showed efficient removal of parvoviruses( Gustafsson et al. 2016b): maybe a new filtration media for viral clearance? |
| cord-287711-gw8mgg4m | The presence of salts enhanced virus adsorption to cellulose ester membranes, this effect increasing with the cation valence( i.e., Al 3? |
| cord-287711-gw8mgg4m | The triple layered A1HC filter media from EMD Millipore include two depth filtration layers( cellulose? diatomaceous earth) of different grades and a 0.1 lm- pore- size microporous membrane pre- filter made of mixed cellulose esters( van Reis and Zydney 2007). |
| cord-287711-gw8mgg4m | [ Mg 2? |
| cord-287711-gw8mgg4m | [ Na?) |
| cord-287711-gw8mgg4m | n95 or surgical masks? |
| cord-318495-1w74wf02 | Can DVGs be harnessed for the control of virus pathogenesis and spread? |
| cord-318495-1w74wf02 | Do DVGs exist for a reason? |
| cord-318495-1w74wf02 | Does the higher order structure of the influenza virus ribonucleoprotein guide sequence rearrangements in influenza viral RNA? |
| cord-318495-1w74wf02 | How do alterations in the DVG population impact virus evolution and adaptation to new hosts? |
| cord-318495-1w74wf02 | How do host factors impact DVG accumulation and activity? |
| cord-318495-1w74wf02 | Random products or encoded in the viral genome? |
| cord-318495-1w74wf02 | Recent work has provided new appreciation for DVG diversity and the potentially critical role of DVGs in defining the clinical outcome of infections; however, a number of questions remain unanswered: what are the molecular mechanisms driving the generation of DVGs? |
| cord-318495-1w74wf02 | Virus- associated small satellite RNAs and viroids display similarities in their replication strategies What has been happening with viroids? |
| cord-318495-1w74wf02 | Why keep waste lying around? |
| cord-318495-1w74wf02 | neurochemical abnormalities in the central nervous system Defective interfering particles: effects in modulating virus growth and persistence Persistence of virulent Semliki Forest virus in mouse brain following co- inoculation with defective interfering particles Defective interfering virus particles modulate virulence Continuous influenza virus production in cell culture shows a periodic accumulation of defective interfering particles Multiple- hit inhibition of infection by defective interfering particles Defective interfering particles of human parainfluenza virus type 3 are associated with persistent infection in cell culture Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad- spectrum antivirals? |
| cord-287758-da11ypiy | ( COVID-19) Clinically Significant Drug Interactions with Cyclosporin Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/ Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus( MERS- CoV), and Severe Acute Respiratory Syndrome Coronavirus( SARS- CoV) Discovery and development of safe- in- man broadspectrum antiviral agents Teicoplanin: an alternative drug for the treatment of COVID-19? |
| cord-287758-da11ypiy | : cord-287758-da11ypiy authors: Mônica Vitalino de Almeida, Sinara; Cleberson Santos Soares, José; Lima dos Santos, Keriolaine; Emanuel Ferreira Alves, Josival; Galdino Ribeiro, Amélia; Trindade Tenório Jacob, Íris; Juliane da Silva Ferreira, Cindy; Celerino dos Santos, Jéssica; Ferreira de Oliveira, Jamerson; Bezerra de Carvalho Junior, Luiz; do Carmo Alves de Lima, Maria title: COVID-19 therapy: what weapons do we bring into battle? |
| cord-287758-da11ypiy | A Review of Its Use in the Management of HIV-1 Infection Discovering drugs to treat coronavirus disease 2019( COVID-19) Therapeutic Options and Critical Care Strategies in COVID-19 Patients; Where Do We Stand in This Battle? |
| cord-287758-da11ypiy | A new trick for an old drug? |
| cord-287758-da11ypiy | Antiviral treatment of COVID-19 Hydroxychloroquine and ivermectin: A synergistic combination for COVID-19 chemoprophylaxis and treatment? |
| cord-287758-da11ypiy | Clinical course and outcomes of critically ill patients with SARS- CoV-2 pneumonia in Wuhan, China: a single- centered, retrospective, observational study Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-287758-da11ypiy | Engineering an antiviral for COVID-19? |
| cord-287758-da11ypiy | How Far Are We? |
| cord-287758-da11ypiy | The Use of Cyclosporine A in Rheumatology: a 2016 Comprehensive Review Cyclosporine A: a valid candidate to treat COVID-19 patients with acute respiratory failure? |
| cord-287758-da11ypiy | The possible mechanisms of action of 4-aminoquinolines( chloroquine/ hydroxychloroquine) against Sars- Cov-2 infection( COVID-19): A role for iron homeostasis? |
| cord-287758-da11ypiy | The world is facing a huge challenge in the coronavirus disease( COVID-19) pandemic: How to fight an enemy without weapons in terms of therapy? |
| cord-304424-048xo7jn | A novel paramyxovirus? |
| cord-304424-048xo7jn | And what exactly did the host look like then? |
| cord-304424-048xo7jn | Are we missing half of the viruses in the ocean? |
| cord-304424-048xo7jn | At what point in host evolution does an RNA viral pathogen arrive? |
| cord-304424-048xo7jn | CRISPR- Cas9 Species- level deconvolution of metagenome assemblies with Hi- C- based contact probability maps Virus discovery: are we scientists or genome collectors? |
| cord-304424-048xo7jn | Metagenomics for the discovery of novel human viruses Global epidemiology of noninfluenza RNA respiratory viruses: data gaps and a growing need for surveillance Viral metagenomics on animals as a tool for the detection of zoonoses prior to human infection? |
| cord-304424-048xo7jn | Other than sampling more broadly and maintaining the exponential growth in Genbank, what are orthogonal challenges for future RNA virus metagenomic studies? |
| cord-304424-048xo7jn | Tombusviridae and Nodaviridae? |
| cord-304424-048xo7jn | What do you get when you cross a picornavirus and a calicivirus? |
| cord-304424-048xo7jn | Where do we begin with RNA virus metagenomics? |
| cord-304424-048xo7jn | Why has RNA virus metagenomics been so successful? |
| cord-318853-mxyxwkhx | 5 5'UTR geq/ ml at 16 weeks be visible immunologically, but envelope proteins derived from EeRNA sequences corresponding to~10 6- 7 5'UTR geq/ ml at 4- 6 weeks remain unseen? |
| cord-318853-mxyxwkhx | Analysis of cloned DNA gives cleaner data than PCR sequencing but if 100 clones( and multiple HCV quasispecies clones are highly unlikely to be identical) provides definitive sequence, would we process the 101 st to reveal different and, potentially, critical sequence variations? |
| cord-318853-mxyxwkhx | And if we did, how would we recognise its importance? |
| cord-318853-mxyxwkhx | As clear evidence exists for viral disruption of leptin function[ 106] and virus- associated weight gain in humans[ 107] and monkeys[ 108], is it possible the global epidemics of type II diabetes mellitus, insulin resistance, hyperlipidaemia and obesity now prevalent[ 109][ 110][ 111][ 112][ 113][ 114][ 115][ 116], are just that; epidemics fundamentally caused by viruses that co- opt insulin or leptin or other associated receptors for cell access and generate protein quasispecies that disrupt receptor function? |
| cord-318853-mxyxwkhx | But does this certitude reflect reality, at least for viral RNA quasispecies? |
| cord-318853-mxyxwkhx | But why should specific EeRNA sequence frequencies-in other words, HCV RNA pol fidelity-increase after week 8, facilitating adaptive immune responses? |
| cord-318853-mxyxwkhx | Could it also be that ethnically based epidemics of obesity, diabetes mellitus, hypertension and reno- vascular disease( the'metabolic syndrome'), as seen in PIMA Indians, Nauruans and Australian Aborigines[ 115] have developed not primarily because of exposure to"Western"foods and lifestyles-that, after all, are all- pervasive without necessarily having so dramatic an effect on other groups-but because of chronic or recurrent exposure to viruses, or genotypes of viruses to which their particular repertoire of receptor polymorphisms confer no protection? |
| cord-318853-mxyxwkhx | Finally, if immune mechanisms are unable to clear RNA viruses like HCV and do not cause the reduced viral replication seen during acute infection, are they any more likely to be effective against other RNA viruses? |
| cord-318853-mxyxwkhx | I receptor signaling system in JC virus T antigen- induced primitive neuroectodermal tumors-medulloblastomas Hepatitis C virus down- regulates insulin receptor substrates 1 and 2 through up- regulation of suppressor of cytokine signaling 3 Vaccinia virus and the EGF receptor: a portal for infectivity? |
| cord-318853-mxyxwkhx | Is important sequence likely to be present at frequencies of http://www.virologyj.com/content/2/1/70< 1%? |
| cord-318853-mxyxwkhx | Is it possible foetal tolerance is mediated by regulating the fidelity of foetal DNA dependent RNA transcriptases to ensure any cell- surface antigens are expressed heterogeneously and at levels below the threshold of maternal immune responsiveness? |
| cord-318853-mxyxwkhx | Is it possible that self- limiting infections like influenza and SARS also autoregulate their replication, and, like HCV or HBV, become partially dormant, yet remain transcriptionally active, in the face of an active and powerful immune response? |
| cord-318853-mxyxwkhx | The expected consequences disruption of receptor function by variant viral proteins might explain many common biochemical pathologies; For example, what effect would chronic blockade of parathyroid( PTH) receptors by viral proteins have on PTH levels, the parathyroid glands, or bone? |
| cord-318853-mxyxwkhx | This is certainly an accurate synthesis of an extensive and highly complex literature but does it make any sense? |
| cord-318853-mxyxwkhx | What practical meaning does"immune control"have for the individual? |
| cord-318853-mxyxwkhx | Why should HCV replicating at 10 6- 7 geq/ ml at week 6 be invisible to the immune system but visible when replicating at 10 5 geq/ ml long term? |
| cord-353609-no3mbg5d | A virus reveals population structure and recent demographic history of its carnivore host Parasites: Proxies for host genealogy and ecology? |
| cord-353609-no3mbg5d | And how might co- infections with these undiscovered viruses influence the dynamics of the more well known viruses? |
| cord-353609-no3mbg5d | And what are the relative roles of genetic relatedness and contact rate for transmission? |
| cord-353609-no3mbg5d | And what are the relative roles of genetic relatedness and contact rate for transmission? |
| cord-353609-no3mbg5d | Are we in the midst of the sixth mass extinction? |
| cord-353609-no3mbg5d | As such, wild populations of rodents can be valuable as model disease systems to address relevant questions like: Are there key hosts for transmission? |
| cord-353609-no3mbg5d | As technology becomes more affordable, and thus accessible, there will be increasing opportunities to ask large- scale questions such as: How does the virosphere vary across space and time? |
| cord-353609-no3mbg5d | Can we use this to define risk of cross- species transmission or to inform conservation efforts? |
| cord-353609-no3mbg5d | Could parasites destabilize mouse populations? |
| cord-353609-no3mbg5d | For instance, what characteristics of hosts and viruses make them more or less likely to be involved in cross- species transmission? |
| cord-353609-no3mbg5d | How do these pathogens flow through populations? |
| cord-353609-no3mbg5d | How does it vary across species? |
| cord-353609-no3mbg5d | How does prevalence vary seasonally or over time? |
| cord-353609-no3mbg5d | How many species? |
| cord-353609-no3mbg5d | Pending questions include: Which geographic areas will experience more disease and conservation problems? |
| cord-353609-no3mbg5d | The peopling of the Pacific from a bacterial perspective Distinguishing human ethnic groups by means of sequences from Heliclobacter pylori: Lessons from Ladakh A parasite reveals cryptic phylogeographic history of its host Are lice good proxies for host history? |
| cord-353609-no3mbg5d | What characteristics of hosts and viruses make them more or less likely to be involved in cross- species transmission events? |
| cord-353609-no3mbg5d | What is the contact rate between the reservoir and humans? |
| cord-353609-no3mbg5d | Which areas pose the highest risk for pandemic spread of pathogens? |