trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
as well as	628
the presence of	589
in order to	563
structure of the	414
one of the	384
based on the	377
of the protein	345
the formation of	336
the structure of	317
the use of	291
the development of	290
due to the	281
the number of	274
in the presence	268
the effect of	262
can be used	234
the role of	233
the synthesis of	217
a number of	207
in this study	197
of the peptide	193
crystal structure of	190
it has been	188
analysis of the	183
the active site	176
a series of	173
the mechanism of	167
a variety of	166
be used to	164
to determine the	159
to study the	155
the design of	155
in this work	155
in addition to	154
to investigate the	152
the interaction of	148
properties of the	147
the case of	147
involved in the	146
part of the	146
by means of	143
a set of	141
found to be	137
show that the	137
molecular dynamics simulations	136
in the case	136
the binding of	133
in terms of	131
the effects of	130
that can be	129
understanding of the	128
was used to	127
the study of	127
of the most	126
the crystal structure	125
of the two	124
of a protein	124
the secondary structure	124
well as the	123
the aim of	122
with respect to	122
amino acid residues	120
been shown to	120
the analysis of	120
shown to be	120
to be a	119
the identification of	119
on the other	118
in the present	118
the amino acid	118
a combination of	116
the ability to	116
have shown that	115
changes in the	114
role in the	113
was found to	112
has been shown	111
the ability of	111
the absence of	111
structures of the	110
is based on	110
the importance of	110
such as the	110
as a result	110
the surface of	108
is one of	108
the other hand	107
there is a	107
we found that	106
structure of a	105
of amino acids	103
the results of	103
related to the	102
the influence of	102
activity of the	101
according to the	101
the plasma membrane	101
region of the	100
the basis of	100
of the human	100
the treatment of	99
used as a	98
compared to the	98
it is possible	98
showed that the	97
of the membrane	97
the interaction between	96
responsible for the	96
the activity of	96
to understand the	96
an important role	95
in which the	95
based on a	93
in the absence	93
protein data bank	92
the stability of	92
the fact that	90
some of the	89
we show that	89
results show that	89
are able to	88
important role in	88
amino acid sequence	88
were able to	87
we have developed	87
to that of	87
nature of the	87
formation of the	87
the binding site	87
shown that the	86
on the surface	86
role of the	85
and in the	85
were used to	85
function of the	85
the application of	85
wide range of	85
most of the	85
a function of	84
crystal structures of	84
been used to	84
suggest that the	83
on the basis	83
the present study	82
large number of	82
a wide range	82
are involved in	82
found that the	81
the existence of	80
the size of	80
associated with the	80
because of the	80
stability of the	80
depends on the	79
the function of	79
the structures of	79
was carried out	79
of the proteins	79
formation of a	79
of the binding	79
be used for	78
the regulation of	78
the discovery of	78
the structure and	78
as a function	77
residues in the	77
in contrast to	77
of the cell	77
effect of the	77
of this study	77
was supported by	77
of amino acid	76
for the development	76
were found to	75
this work was	75
of the structure	75
structure and function	74
to identify the	73
will be discussed	73
found in the	73
have been used	73
that of the	73
will be presented	73
of the rna	72
of the n	72
in the protein	72
in the same	72
phase peptide synthesis	72
the free energy	72
of the enzyme	72
results suggest that	71
in complex with	71
is possible to	71
are known to	71
the conformation of	70
used for the	70
known to be	70
aim of this	70
in vitro and	69
and in vivo	69
in response to	69
present in the	69
the end of	68
atomic force microscopy	68
of the c	68
depending on the	68
study of the	68
the rate of	68
of the target	67
we present a	67
the nature of	67
information on the	67
a large number	67
the range of	67
binding to the	67
the production of	66
a range of	66
is able to	66
model of the	66
be involved in	66
revealed that the	66
the process of	66
rna secondary structures	66
was shown to	66
has been used	65
the prediction of	65
and can be	65
to be the	65
size of the	65
in the pdb	65
each of the	65
insight into the	64
characterization of the	64
the dynamics of	64
of the peptides	64
which can be	64
derived from the	63
conformation of the	63
surface of the	63
binding of the	63
due to its	63
the accuracy of	63
interaction with the	63
the determination of	63
interactions between the	63
interaction of the	63
for the treatment	62
at the n	62
the sequence of	62
to evaluate the	62
here we present	62
is known to	61
nuclear magnetic resonance	61
mechanism of action	61
is involved in	61
information about the	61
of the complex	61
is used to	61
as a model	60
effect on the	60
secondary structure of	60
have been developed	60
the kinetics of	60
the target protein	60
in combination with	60
the level of	60
we report the	60
determination of the	60
the majority of	59
structural and functional	59
has also been	59
for the design	59
at the c	59
be used as	59
similar to that	59
of the same	58
the lack of	58
the properties of	58
presence of a	58
of the ligand	58
to interact with	58
key role in	58
which is a	58
a result of	58
of the three	58
of the amino	58
of these peptides	58
of the compounds	58
there is no	57
the amount of	57
to predict the	57
we have used	57
used in the	57
of the sars	57
state of the	57
of the virus	57
to improve the	57
mechanism of the	57
proteins in the	57
the distribution of	57
d structure of	56
we investigated the	56
has not been	56
a role in	56
the cell membrane	56
work was supported	56
the detection of	56
end of the	56
length of the	56
between the two	56
and it is	56
features of the	56
can also be	56
it was shown	56
is required for	56
of the viral	55
biological activity of	55
the protein data	55
change in the	55
presence of the	55
due to their	55
vitro and in	55
of a new	55
intrinsically disordered proteins	55
in the cell	55
we were able	55
severe acute respiratory	55
acute respiratory syndrome	55
a key role	55
in living cells	55
the lipid bilayer	54
seems to be	54
leading to the	54
the present work	54
increase in the	54
amino acid sequences	54
this study we	54
consistent with the	54
is an important	54
we have shown	54
results indicate that	54
members of the	54
shown in fig	54
it can be	54
it was found	54
insights into the	53
rna secondary structure	53
was used as	52
is shown in	52
study was to	52
were carried out	52
to elucidate the	52
this study was	52
to form a	52
it is a	51
member of the	51
amino acids and	51
indicate that the	51
corresponding to the	51
we have also	51
close to the	51
have also been	51
for the synthesis	51
of a novel	51
of a single	50
in the development	50
of action of	50
active site of	50
all of the	50
this work we	50
play an important	50
protein structure prediction	50
in the membrane	50
interaction between the	50
and characterization of	50
the quality of	50
observed in the	50
a database of	50
solid phase peptide	50
the degree of	50
the length of	50
and function of	50
the combination of	49
domain of the	49
our understanding of	49
appears to be	49
is essential for	49
shows that the	49
to the formation	49
at the same	49
transmission electron microscopy	49
that have been	49
site of the	49
suggests that the	49
the possibility of	49
the most common	49
is due to	49
and dynamics of	49
van der waals	49
some of these	48
at the end	48
the activation of	48
the introduction of	48
is responsible for	48
have not been	48
for the first	48
was found that	48
to analyze the	48
use of the	48
is associated with	47
we present the	47
the side chain	47
led to the	47
the preparation of	47
respect to the	47
has been developed	47
the first time	47
that there is	47
of membrane proteins	47
on the structure	47
sequence of the	47
we studied the	47
a and b	47
be used in	46
in the first	46
dynamics of the	46
supported by the	46
the fi rst	46
used to determine	46
located in the	46
the characterization of	46
of protein structure	46
were shown to	46
in the literature	46
amino acids in	46
to be involved	45
the most important	45
their ability to	45
it is not	45
in this context	45
is crucial for	45
results of the	45
structure and dynamics	45
we have studied	45
addition to the	45
in the range	45
of the native	45
are shown in	45
have been identified	45
differences in the	45
in the brain	45
knowledge of the	45
the expression of	45
regions of the	45
free energy of	45
of the interaction	45
we showed that	45
comparison of the	45
dynamic light scattering	44
structures in the	44
formed by the	44
studies of the	44
determined by the	44
the interaction with	44
of these proteins	44
characterized by a	44
many of the	44
as compared to	44
to the protein	44
isothermal titration calorimetry	44
allowed us to	44
development of a	44
focused on the	43
to explore the	43
in this case	43
interact with the	43
we have investigated	43
the concentration of	43
need to be	43
structural basis for	43
contribute to the	43
are used to	43
amino acid composition	43
the relationship between	43
the wild type	43
a total of	42
which is the	42
and molecular dynamics	42
in recent years	42
been shown that	42
has been proposed	42
of the sequence	42
was shown that	42
appear to be	42
of protein structures	42
of the dna	42
a family of	42
we have found	42
of this work	42
the context of	42
the biological activity	42
have been found	42
of proteins and	42
department of chemistry	42
scanning electron microscopy	41
fluorescence correlation spectroscopy	41
than that of	41
the growth of	41
by using the	41
in the regulation	41
dependent on the	41
leads to the	41
is that the	41
academy of sciences	41
in the sequence	41
were synthesized by	41
to assess the	41
applied to the	41
is a key	41
of the molecule	41
used to study	41
central nervous system	41
together with the	41
the search for	41
of rna secondary	41
peptides and proteins	41
different types of	41
followed by a	41
basis of the	40
in agreement with	40
the course of	40
of a large	40
our results show	40
we developed a	40
belongs to the	40
it is also	40
demonstrated that the	40
the inhibition of	40
a member of	40
to the membrane	40
have been studied	40
position of the	40
suggested that the	40
studies on the	40
important for the	40
resulted in the	40
the generation of	40
is important to	39
is composed of	39
in the formation	39
interactions with the	39
the incorporation of	39
of secondary structure	39
here we report	39
in the structure	39
are characterized by	39
the action of	39
well as in	39
compared with the	39
to obtain the	39
synthesis of the	39
for the study	39
leads to a	39
depend on the	39
attached to the	39
to characterize the	39
shown in figure	39
could be used	39
binding site of	39
secondary structure prediction	38
basis for the	38
it is important	38
the protein is	38
the interactions between	38
similar to the	38
prediction of protein	38
regulation of the	38
plays an important	38
the cell surface	38
surface plasmon resonance	38
the set of	38
component of the	38
the structural and	38
in comparison with	38
for drug discovery	38
of the a	38
the purpose of	38
peptides derived from	38
better understanding of	38
in the binding	38
the same time	38
of intrinsic disorder	38
in aqueous solution	38
of which are	38
the mechanisms of	38
this is the	38
obtained from the	38
in the past	38
bound to the	38
of the molecular	38
side of the	38
the synthesis and	38
a model of	38
be able to	38
have been shown	37
development of new	37
new class of	37
the d structure	37
be considered as	37
these results suggest	37
is the most	37
the protein structure	37
of the reaction	37
are based on	37
an example of	37
in the field	37
secondary and tertiary	37
referred to as	37
in case of	37
and that the	37
is characterized by	37
of the lipid	37
in this way	37
by using a	37
the position of	37
is believed to	37
also known as	37
likely to be	37
effects of the	37
the assembly of	36
acts as a	36
out of the	36
secondary structure elements	36
in presence of	36
has been suggested	36
human immunodeficiency virus	36
a protein structure	36
orientation of the	36
with the same	36
in the following	36
of proteins in	36
increase of the	36
the impact of	36
method for the	36
agreement with the	36
in the context	36
the order of	36
we have been	36
of the s	36
to be used	36
caused by the	36
investigation of the	36
results showed that	36
suggesting that the	36
the basis for	36
this type of	36
the investigation of	35
influence of the	35
inhibitors of the	35
inhibition of the	35
of the active	35
based on these	35
we used the	35
the field of	35
model for the	35
can be found	35
the changes in	35
we find that	35
and of the	35
the results obtained	35
belonging to the	35
the amino acids	35
have to be	35
of a peptide	35
and for the	35
based drug design	35
resulted in a	35
by the presence	35
the binding pocket	35
be applied to	35
synthesis of a	35
of all the	35
that it is	35
molecular mechanism of	35
ability of the	35
of the receptor	35
of this protein	35
of the model	35
as shown in	35
two types of	35
of the main	35
residues of the	35
a powerful tool	35
step in the	34
required for the	34
have developed a	34
this work is	34
structure in the	34
serve as a	34
results in a	34
the understanding of	34
has to be	34
accuracy of the	34
can be obtained	34
to each other	34
is important for	34
based on their	34
to bind to	34
the molecular level	34
contrast to the	34
of the different	34
in the central	34
on the cell	34
of the first	34
allows us to	34
of antimicrobial peptides	34
vp vp vp	34
the release of	34
of the resulting	34
have been reported	34
to be more	34
have been proposed	34
for this purpose	33
are responsible for	33
the addition of	33
was applied to	33
the evolution of	33
de novo design	33
organization of the	33
be related to	33
in silico pharmacology	33
the results show	33
in drug discovery	33
was used for	33
we have recently	33
to obtain a	33
can be applied	33
there is an	33
has been studied	33
the eudoc program	33
dynamics simulations of	33
is consistent with	33
the interactions of	33
to play a	33
the side chains	33
been found to	33
and in vitro	33
in the last	33
the first step	33
resonance energy transfer	33
at least one	33
of the secondary	33
proteins involved in	33
considered to be	33
of the sample	33
of the major	33
to develop a	33
in the n	33
terminal domain of	33
the potential of	33
protein structure and	32
mode of action	32
with the aim	32
thought to be	32
point of view	32
is a powerful	32
the central nervous	32
intrinsic disorder in	32
the host cell	32
the complexity of	32
structural analysis of	32
one or more	32
structures can be	32
to increase the	32
at least two	32
of the molecules	32
in the future	32
used to identify	32
a model system	32
dependence of the	32
the location of	32
components of the	32
of protein folding	32
the human genome	32
be responsible for	32
in a single	32
for the binding	31
proteins can be	31
dependent rna polymerase	31
bind to the	31
was studied by	31
an increase in	31
the in vitro	31
solid phase synthesis	31
conformational changes in	31
to the presence	31
data suggest that	31
in vivo and	31
assembly of the	31
was able to	31
reduction of the	31
rational design of	31
evaluation of the	31
to inhibit the	31
a class of	31
are associated with	31
form of the	31
its interaction with	31
in some cases	31
as a consequence	31
designed and synthesized	31
on the protein	31
because of their	31
the construction of	30
of the structures	30
and on the	30
have investigated the	30
the tertiary structure	30
em structure of	30
in the peptide	30
consists of a	30
methods have been	30
to have a	30
parts of the	30
the crystal structures	30
interactions in the	30
of the four	30
of secondary structures	30
is the first	30
we propose that	30
has been determined	30
in a protein	30
in the crystal	30
a group of	30
at the molecular	30
secondary structure and	30
details of the	30
importance of the	30
could not be	30
the molecular mechanism	30
to the cell	30
be important for	30
distribution of the	30
of these two	30
so that the	30
the resolution of	30
carried out using	30
the type of	30
molecules in the	30
we will present	30
wide variety of	30
the significance of	30
which has been	30
of the catalytic	30
is used for	30
is related to	30
structural characterization of	30
the behavior of	30
the binding affinity	30
may lead to	29
for the detection	29
it is well	29
is known that	29
we used a	29
activation of the	29
in escherichia coli	29
is a very	29
the performance of	29
energy of the	29
prediction of the	29
at room temperature	29
the concept of	29
structure determination of	29
based virtual screening	29
the molecular mechanisms	29
were used as	29
has been found	29
when compared to	29
in the early	29
the folding of	29
seem to be	29
the occurrence of	29
starting from the	29
as in the	29
results in the	29
a secondary structure	29
of the system	29
it is known	29
identification of a	29
by nmr spectroscopy	29
can be easily	29
diseases such as	29
of the surface	29
believed to be	29
that there are	29
we have synthesized	29
in the c	29
can be considered	29
of the full	29
and the other	29
a crucial role	29
because of its	29
use of a	29
have found that	29
changes of the	29
conformational changes of	29
carried out by	29
taken into account	29
of these structures	29
shape of the	28
isolated from the	28
lead to the	28
the rest of	28
values of the	28
has been reported	28
be due to	28
core of the	28
in most cases	28
we have designed	28
of the new	28
its ability to	28
molecular dynamics simulation	28
effects on the	28
is necessary to	28
in the second	28
act as a	28
indicated that the	28
dimensional structure of	28
the peptides were	28
the loss of	28
are important for	28
to measure the	28
the goal of	28
the control of	28
in the human	28
with a high	28
that could be	28
in a variety	28
in the treatment	28
linked to the	28
a change in	28
of these compounds	28
this is a	28
to examine the	28
the evaluation of	28
we have previously	28
serves as a	28
has recently been	28
dimensional structures of	28
similar to those	28
structure and the	28
in the active	28
we propose a	28
proven to be	28
reactive oxygen species	28
is likely to	28
of structural biology	28
proved to be	28
crucial for the	28
difference between the	28
amino acid residue	27
the affinity of	27
a part of	27
peptides were synthesized	27
play a role	27
in this paper	27
needs to be	27
light on the	27
with high affinity	27
is present in	27
the form of	27
mechanical properties of	27
that they are	27
identifi cation of	27
view of the	27
to the active	27
design of new	27
been applied to	27
binds to the	27
identification of the	27
of a small	27
expected to be	27
is mediated by	27
in the s	27
a mixture of	27
to better understand	27
located at the	27
force field for	27
correlation between the	27
leading to a	27
for the discovery	27
is thought to	27
to the same	27
data on the	27
of the crystal	27
we describe the	27
to calculate the	27
data show that	27
composition of the	27
studies showed that	27
considered as a	27
of the p	27
a highly conserved	27
was determined by	27
native chemical ligation	27
recent advances in	27
a wide variety	27
and biological activity	27
along with the	27
and the c	27
activity in the	27
this study is	27
mediated by the	27
plays a key	27
it should be	27
may be a	27
may not be	27
some of them	26
of the entire	26
the details of	26
there are several	26
to those of	26
were subjected to	26
more than one	26
high affi nity	26
studies have shown	26
be found in	26
have been described	26
side chains of	26
is capable of	26
were used for	26
of the conformational	26
cleavage of the	26
order to obtain	26
deposited in the	26
case of the	26
sequence and structure	26
powerful tool for	26
the efficiency of	26
affected by the	26
relies on the	26
allow us to	26
institute of technology	26
terminus of the	26
essential for the	26
been implicated in	26
crucial role in	26
department of physics	26
to reduce the	26
that may be	26
access to the	26
is supported by	26
were synthesized and	26
a comparison of	26
been suggested that	26
induced by the	26
of such a	26
of the second	26
relative to the	26
the specificity of	26
which have been	26
confocal laser scanning	26
to the n	26
characterization of a	26
to test the	26
and development of	26
a method for	26
the availability of	26
that has been	26
this approach is	26
a better understanding	26
a model for	26
used to predict	26
the orientation of	26
belong to the	26
of small molecules	26
based on this	26
a new method	26
in the design	26
were prepared by	26
virtual screening of	26
proteins and their	26
has been recently	26
with and without	26
a new class	25
the protein surface	25
of proteins with	25
a library of	25
side chain of	25
rest of the	25
attributed to the	25
as an example	25
a basis for	25
these peptides are	25
we believe that	25
of more than	25
amino acids were	25
characterized by the	25
are found in	25
scanning electron microscope	25
and tertiary structure	25
change of the	25
are the most	25
properties of a	25
the results are	25
our results suggest	25
is essential to	25
binding sites in	25
to understand how	25
amino acids are	25
were characterized by	25
into account the	25
interacts with the	25
of the drug	25
and structure of	25
size exclusion chromatography	25
in the two	25
quality of the	25
well as to	25
the organization of	25
to the structure	25
consists of two	25
protein in the	25
due to a	25
by solid phase	25
we demonstrate that	25
correlated with the	25
molecular basis of	25
been developed for	25
the result of	25
of peptides and	25
have been investigated	25
that are not	24
and has been	24
background and aims	24
is a major	24
are used in	24
indicating that the	24
we investigate the	24
is determined by	24
the compounds were	24
in the plasma	24
we conclude that	24
structural properties of	24
of the host	24
of the folding	24
majority of the	24
indicates that the	24
part of a	24
of base pairs	24
we suggest that	24
of the structural	24
order to study	24
a major role	24
the polypeptide chain	24
the university of	24
tool for the	24
the difference in	24
the protein and	24
we report on	24
in the identification	24
evolution of the	24
low molecular weight	24
and nucleic acids	24
and to the	24
the viral rna	24
limited number of	24
structures have been	24
be useful for	24
only a few	24
the most potent	24
to monitor the	24
carried out in	24
been found in	24
processes such as	24
differential scanning calorimetry	24
structure of human	24
the molecular basis	24
aim is to	24
using a combination	24
is dependent on	24
in relation to	24
amino acid side	24
this suggests that	24
to create a	24
in our laboratory	24
that do not	24
work was to	24
be associated with	24
is formed by	24
small angle x	24
institute of biophysics	24
the possibility to	24
by molecular dynamics	24
those of the	24
the local structures	24
focus on the	24
is known about	24
on the membrane	24
they can be	24
interacting with the	24
orders of magnitude	24
starting point for	24
taking into account	24
of rna structure	24
differences between the	24
to explain the	24
the aggregation of	24
it is the	24
protein can be	24
of a given	24
proteins and peptides	24
for the prediction	24
to form the	24
used as the	24
in other words	24
the target sequence	24
in spite of	24
in the cytoplasm	23
we report a	23
the center of	23
is the main	23
order to understand	23
of amyloid fibrils	23
may be used	23
affinity of the	23
to control the	23
the experimental data	23
were obtained from	23
advantage of the	23
it possible to	23
states of the	23
of local structures	23
we demonstrated that	23
evidence that the	23
simulations of the	23
and analysis of	23
also in the	23
high degree of	23
in comparison to	23
across the membrane	23
sites of the	23
of glutamic acid	23
the most promising	23
for the preparation	23
concentration of the	23
by circular dichroism	23
the in vivo	23
the pathogenesis of	23
the increase of	23
on the use	23
both in the	23
it may be	23
the help of	23
of the backbone	23
added to the	23
cell penetrating peptides	23
it is necessary	23
structural features of	23
upon binding to	23
carried out on	23
resulting in the	23
molecular mechanisms of	23
the design and	23
were tested for	23
a consequence of	23
of protein function	23
flexibility of the	23
been used for	23
on the interaction	23
has been demonstrated	23
ray crystallography and	23
in many cases	23
that the protein	23
amino acids with	23
of the free	23
of the hiv	23
the calculation of	23
the hypothesis that	23
for the identification	23
of the complexes	23
in the process	23
the contribution of	23
the peptide backbone	23
secondary structure is	23
conformational analysis of	23
to the development	23
glutamic acid residues	23
the problem of	23
complex with the	23
to describe the	23
proteins of the	23
the mode of	23
we aim to	22
in the number	22
that the structure	22
a hydrogen bond	22
the selection of	22
of this enzyme	22
corresponds to the	22
mutations in the	22
antimicrobial activity against	22
d structures of	22
example of a	22
and stability of	22
such as a	22
work is to	22
a decrease in	22
the extent of	22
liu et al	22
conformations of the	22
the reaction of	22
been identified in	22
is a potent	22
the association of	22
by mass spectrometry	22
peptides have been	22
is represented by	22
structure of an	22
approaches have been	22
has led to	22
interactions of the	22
which may be	22
is well known	22
to find the	22
study is to	22
removal of the	22
to show that	22
each of these	22
of the electron	22
more stable than	22
of the residues	22
existence of a	22
known as the	22
the distance between	22
the increase in	22
unnatural amino acids	22
amino acids that	22
associated with a	22
complexity of the	22
of the present	22
of the protease	22
under physiological conditions	22
is achieved by	22
action of the	22
distance between the	22
are essential for	22
in conjunction with	22
the shape of	22
on the molecular	22
of the d	22
resulting from the	22
description of the	22
to determine whether	22
in the rat	22
to provide a	22
of the natural	22
but it is	22
plasma membrane of	22
rdrp suppl table	22
of hydrogen bonds	22
is not a	22
web server for	22
geometry of the	22
structural basis of	22
atoms of the	22
on the structural	22
to be an	22
has been observed	22
of a series	22
and the structure	22
is similar to	22
is possible that	22
of this approach	22
modification of the	22
two of the	22
portion of the	22
of the substrate	22
from the protein	22
small number of	22
well as their	22
were determined by	22
hepatitis c virus	22
to estimate the	22
half of the	22
affinity for the	22
solution structure of	22
application of the	22
is still a	22
were obtained by	22
of the other	22
order to investigate	22
respiratory syndrome coronavirus	22
was to investigate	22
it does not	22
has shown that	22
characteristics of the	21
the conformational changes	21
the focus of	21
led to a	21
an understanding of	21
is in the	21
lead to a	21
multiple sequence alignment	21
a way that	21
of both the	21
tested for their	21
in the other	21
the extracellular matrix	21
difference in the	21
provided by the	21
can be observed	21
of the non	21
model based on	21
nucleotides in the	21
demonstrate that the	21
was observed in	21
acid residues in	21
in the form	21
the secondary structures	21
we use the	21
this class of	21
the binding sites	21
has been identified	21
university of california	21
results from the	21
with the protein	21
mechanisms of action	21
are likely to	21
been widely used	21
a method to	21
broad range of	21
of the genome	21
interest in the	21
resolution of the	21
seen in the	21
of the b	21
the potential to	21
roles in the	21
with that of	21
an in vitro	21
profile of the	21
to be highly	21
the core of	21
by interacting with	21
can be seen	21
terminal part of	21
little is known	21
the measurement of	21
inhibitor of the	21
the correlation between	21
potent and selective	21
have been characterized	21
proteins have been	21
development of the	21
to the peptide	21
is expected to	21
science and technology	21
order to determine	21
to generate a	21
can serve as	21
the geometry of	21
able to bind	21
prediction of rna	21
peptides and their	21
calculation of the	21
decrease of the	21
have studied the	21
of the plasma	21
structure has been	21
to detect the	21
to the surface	21
and amino acid	21
aim of the	21
site in the	21
structures of proteins	21
during the last	21
of the compound	21
to be important	21
the conversion of	21
of the known	20
physical properties of	20
fact that the	20
is regulated by	20
dynamics of a	20
of the corresponding	20
parallel to the	20
of molecular dynamics	20
in the study	20
good agreement with	20
a protein is	20
in a wide	20
of the primary	20
that the n	20
laser scanning microscopy	20
with the help	20
one of these	20
for understanding the	20
to the high	20
developed for the	20
can then be	20
the peptide sequence	20
structural studies of	20
results demonstrate that	20
binding affinity of	20
of the polypeptide	20
the similarity of	20
observed for the	20
to compare the	20
proteins such as	20
were used in	20
is a member	20
as a new	20
the frequency of	20
as determined by	20
department of biophysics	20
are related to	20
is difficult to	20
design and synthesis	20
a novel approach	20
used as an	20
as a template	20
we focus on	20
plays a role	20
are expected to	20
with each other	20
an ensemble of	20
nmr studies of	20
location of the	20
limited by the	20
for binding to	20
the value of	20
of the individual	20
was obtained by	20
in the course	20
in both the	20
the catalytic domain	20
could be a	20
a resolution of	20
of intrinsically disordered	20
have been synthesized	20
we observed that	20
the observation that	20
behavior of the	20
the most active	20
have been determined	20
an attempt to	20
of the nucleocapsid	20
resulting in a	20
of water molecules	20
kinetics of the	20
been studied by	20
graduate school of	20
parameters of the	20
the method is	20
binding of a	20
were performed in	20
secondary structure in	20
over the past	20
of the t	20
been developed to	20
binding free energy	20
for the formation	20
of the g	20
to optimize the	20
cells of the	20
in the search	20
in vivo studies	20
it will be	20
of at least	20
relationship between the	20
studies have been	20
the native state	20
this process is	20
of crystal packing	20
we will show	20
for in vivo	20
cells in the	20
and synthesis of	20
with the membrane	20
phase synthesis of	20
we analyzed the	20
a high degree	20
the modulation of	20
can be achieved	20
approach for the	20
followed by the	20
the creation of	20
approach to the	20
of the whole	20
a critical role	19
in the model	19
of negatively charged	19
and molecular modeling	19
the change in	19
presence of an	19
also be used	19
of the functional	19
to act as	19
secondary structures of	19
suitable for the	19
on the contrary	19
of a number	19
it was also	19
of the data	19
we report here	19
base pair similarity	19
as a potential	19
coordinates of the	19
many of these	19
it was suggested	19
incorporated into the	19
drug discovery process	19
infl uence of	19
techniques such as	19
for each of	19
and found that	19
a target for	19
green fluorescent protein	19
be explained by	19
of our study	19
analysis of a	19
a starting point	19
methods such as	19
is a well	19
purpose of this	19
in the lipid	19
we focused on	19
binding mode of	19
influence on the	19
the reduction of	19
to probe the	19
critical role in	19
potential of the	19
tertiary structure of	19
included in the	19
in the nucleus	19
the viral genome	19
the need for	19
as part of	19
the electron density	19
proteins and nucleic	19
linked to a	19
it is shown	19
on the sequence	19
all of these	19
in the vicinity	19
a subset of	19
the primary structure	19
due to an	19
to reveal the	19
binding site for	19
is a highly	19
the sequence and	19
the native structure	19
in mammalian cells	19
residues involved in	19
of a few	19
the morphology of	19
the binding mode	19
for virtual screening	19
secondary structures are	19
identified in the	19
can lead to	19
assumed to be	19
acid sequence of	19
of gene expression	19
in a large	19
of the wild	19
in our study	19
is an essential	19
be divided into	19
sensitive to the	19
design of a	19
of biologically active	19
binding sites of	19
positions of the	19
of the local	19
the differences in	19
defined by the	19
any of the	19
are present in	19
affi nity for	19
for drug design	19
as it is	19
in the viral	19
gives rise to	19
of in silico	19
goal is to	19
can be determined	19
composed of a	19
of the selected	19
cancer cell lines	19
the origin of	19
major role in	19
proteins that are	19
have been made	19
a new approach	19
in which a	19
an effort to	19
morphology of the	19
for a given	19
linear and cyclic	19
and the binding	19
give rise to	19
we examined the	19
in an effort	19
of the original	19
observed that the	19
design of novel	19
glutamic acid is	19
position in the	19
secondary structures with	19
density of the	19
analysis revealed that	19
the dependence of	19
been proposed to	19
have demonstrated that	19
binding site on	18
formation of an	18
and with the	18
a small number	18
here we show	18
were identified by	18
been carried out	18
of them are	18
correspond to the	18
by the formation	18
the vicinity of	18
of the interactions	18
there are many	18
novo design of	18
of an rna	18
of science and	18
is a promising	18
the toxicity of	18
in a way	18
terminal region of	18
zhang et al	18
the outer membrane	18
to be considered	18
there are two	18
binding domain of	18
at the level	18
in the interaction	18
these proteins are	18
binding properties of	18
development of novel	18
that the binding	18
we are interested	18
and there is	18
has been widely	18
we present an	18
was monitored by	18
do not have	18
homology model of	18
the main chain	18
the major groove	18
can be divided	18
protein secondary structure	18
can only be	18
protein from the	18
of the helix	18
the inclusion of	18
the results showed	18
analysis of protein	18
on a single	18
structures and functions	18
present work we	18
has been described	18
in live cells	18
here we describe	18
the involvement of	18
properties of these	18
a crystal structure	18
protein of the	18
a pair of	18
of the transition	18
efficiency of the	18
only in the	18
essential role in	18
comparison with the	18
divided into two	18
at the single	18
for the investigation	18
of escherichia coli	18
combined with the	18
of the cells	18
the past years	18
protein and the	18
were calculated using	18
structures and the	18
that the peptide	18
for use in	18
be the most	18
sequences of the	18
at least in	18
with the use	18
the elucidation of	18
by a single	18
was studied in	18
in silico screening	18
mechanism by which	18
of some of	18
will be used	18
for all the	18
picture of the	18
example of the	18
in the low	18
the membrane and	18
to the synthesis	18
the values of	18
of the large	18
the fraction of	18
stabilization of the	18
the minor groove	18
discovery of new	18
an increase of	18
the flexibility of	18
there has been	18
biologically active peptides	18
are required to	18
was performed in	18
one of them	18
in regulation of	18
for protein structure	18
which in turn	18
for the interaction	18
we demonstrate the	18
release of the	18
of living cells	18
protein intrinsic disorder	18
as one of	18
to the target	18
was investigated by	18
the template structure	18
with a single	18
s and s	18
in view of	18
unfolding of the	18
functions of the	18
binding site in	18
results indicated that	18
is widely used	18
for treatment of	18
the sum of	18
to overcome this	18
from the n	18
fraction of the	18
in silico methods	18
of binding sites	18
the appearance of	18
p x r	17
with the active	17
the variation of	17
combination of the	17
increasing number of	17
in both cases	17
experiments showed that	17
is caused by	17
by a combination	17
the types of	17
are consistent with	17
has been applied	17
groups of the	17
share a common	17
high levels of	17
conclude that the	17
of the in	17
the virtual screening	17
the sars coronavirus	17
ability to form	17
of the cellular	17
cd and nmr	17
at physiological ph	17
binding sites for	17
the protein in	17
of the bacterial	17
the training set	17
methods for the	17
that the presence	17
the interplay between	17
modulation of the	17
was found in	17
there was a	17
an amino acid	17
of this peptide	17
on the analysis	17
can be a	17
were found in	17
seq x and	17
analysis showed that	17
determined by nmr	17
for the analysis	17
the asymmetric unit	17
motion of the	17
the full length	17
the last years	17
work we have	17
islet amyloid polypeptide	17
acids in the	17
by measuring the	17
important roles in	17
antimicrobial activity of	17
for their ability	17
was performed by	17
developed a novel	17
the development and	17
the peptide was	17
the membrane surface	17
terms of the	17
play a key	17
been associated with	17
degrees of freedom	17
the accumulation of	17
is necessary for	17
target for the	17
these results indicate	17
is a protein	17
of a ligand	17
the monte carlo	17
the method of	17
away from the	17
the region of	17
a glutamic acid	17
and the number	17
the recognition of	17
determined by x	17
is followed by	17
able to interact	17
ranging from to	17
and secondary structure	17
results on the	17
an essential role	17
a single protein	17
modeling of the	17
using nmr spectroscopy	17
of drug discovery	17
our results indicate	17
is part of	17
expressed in the	17
new insights into	17
studies revealed that	17
the coupling of	17
in the outer	17
sequences in the	17
known that the	17
not yet been	17
the template and	17
of the biological	17
protein folding and	17
the functions of	17
the protein to	17
to our knowledge	17
produced by the	17
molecules have been	17
a lot of	17
have the ability	17
of rna molecules	17
of the mechanism	17
also been used	17
can be done	17
are difficult to	17
rna structure prediction	17
we designed a	17
results of this	17
residues at the	17
aim was to	17
is used as	17
peptides can be	17
in the current	17
the most stable	17
in cancer cells	17
studies were performed	17
binding to a	17
integral membrane proteins	17
the advantage of	17
we are currently	17
amino group of	17
of the disulfide	17
models of the	17
number of protein	17
in real time	17
well as a	17
modifi cation of	17
of the actin	17
circular dichroism and	17
is critical for	17
the usefulness of	17
a study of	17
each amino acid	17
of the virion	17
the site of	17
that the two	17
there have been	17
we are able	17
d structural data	16
was based on	16
to mimic the	16
a lipid bilayer	16
of the total	16
are interested in	16
this indicates that	16
with those of	16
the last decade	16
expression of the	16
is the major	16
a very high	16
structural changes in	16
to the fact	16
because they are	16
and mechanism of	16
domain and the	16
in the hydrophobic	16
that the number	16
to establish the	16
comparable to that	16
in determining the	16
to address the	16
fold into a	16
allows for the	16
carried out to	16
the intrinsically disordered	16
of the pore	16
are considered to	16
electrostatic interactions between	16
kagome lattice structure	16
as a basis	16
and the corresponding	16
in the synthesis	16
tools for the	16
in the complex	16
regions in the	16
and compared with	16
described in the	16
elements in the	16
have been widely	16
order to identify	16
sensitivity and selectivity	16
can be studied	16
independent of the	16
to the binding	16
of the process	16
of sequences and	16
of nucleic acid	16
xu et ai	16
structure can be	16
the replacement of	16
enabled us to	16
with the binding	16
was confirmed by	16
in such a	16
study on the	16
and it was	16
and as a	16
potent inhibitors of	16
on solid support	16
approach based on	16
active site and	16
broad spectrum of	16
the selected compounds	16
a homology model	16
in the secondary	16
well known that	16
high affinity for	16
of the central	16
expressed in e	16
that the interaction	16
the innate immune	16
has emerged as	16
of these molecules	16
was achieved by	16
the structural basis	16
a protein with	16
local structures and	16
the decrease of	16
may contribute to	16
as an alternative	16
study of a	16
in protein structures	16
formation of amyloid	16
we have applied	16
a neural network	16
the structural features	16
the knowledge of	16
the proteins were	16
binding site is	16
are considered as	16
are crucial for	16
when compared with	16
the scope of	16
have been performed	16
goal of this	16
for this reason	16
we have demonstrated	16
of the sequences	16
to be responsible	16
of a particular	16
should be noted	16
the sequences of	16
taking advantage of	16
it is believed	16
chemical properties of	16
arrangement of the	16
of the high	16
virtual screening for	16
to changes in	16
peptide derived from	16
an analysis of	16
is found in	16
because it is	16
in the template	16
peptides corresponding to	16
emerged as a	16
our aim is	16
were performed using	16
in an attempt	16
on the nature	16
contributes to the	16
the difference between	16
the content of	16
contribution of the	16
p and p	16
in all cases	16
play a crucial	16
red blood cells	16
of the channel	16
involved in a	16
a single molecule	16
be noted that	16
the protein chain	16
implicated in the	16
in the database	16
a role for	16
vivo and in	16
an in silico	16
may be the	16
structure of this	16
the catalytic site	16
experimental and computational	16
from the literature	16
in water and	16
the actin cytoskeleton	16
structures of rna	16
using circular dichroism	16
the most abundant	16
to be very	16
as a novel	16
order to find	16
of the chemical	16
of the e	16
we study the	16
of a structure	16
could also be	16
molecular mass of	16
of proteins that	16
discovery of novel	16
we carried out	16
of ion channels	16
in the middle	16
the thermal stability	16
the peptide chain	16
found in a	16
activity of a	16
of the h	16
were studied by	16
the binding to	16
domains of the	16
aim of our	16
we have performed	16
very similar to	16
report on the	16
of in vitro	16
of the energy	16
to the identification	16
the integration of	16
the behaviour of	16
cell adhesion and	16
a small molecule	16
comparative analysis of	16
in this region	16
the delivery of	16
selection of the	16
can be explained	16
affi nity and	16
for the production	16
aspects of the	16
was suggested that	16
the in silico	16
been able to	16
content of the	16
explained by the	16
logarithm of the	16
at the cell	16
extension of the	16
for the determination	16
it is likely	16
are among the	16
in a number	16
ray crystal structure	16
the results indicate	16
before and after	16
to confirm the	16
we determined the	16
t h e	16
which could be	16
is limited by	16
it is still	16
proportional to the	16
number of different	16
a list of	16
comparative protein structure	16
widely used for	16
group of the	16
alignment of the	16
means of the	16
recognition of the	16
the transition state	16
to define the	15
a molecular level	15
structure with a	15
single molecule fluorescence	15
of idps idprs	15
have the same	15
note that the	15
the specifi c	15
were investigated by	15
understand the role	15
among the most	15
vast majority of	15
the rational design	15
specificity of the	15
to the c	15
report the synthesis	15
of the coronavirus	15
in this field	15
of the presence	15
have recently been	15
application of this	15
molecular biology and	15
and a c	15
important in the	15
nmr structure of	15
the solid phase	15
of dna and	15
the middle of	15
of the current	15
the vast majority	15
contribution to the	15
the venom of	15
is stabilized by	15
method was used	15
by increasing the	15
is an attractive	15
the hydrophobic core	15
tertiary structures of	15
showing that the	15
may be of	15
order to improve	15
or in the	15
especially in the	15
number of structures	15
most of them	15
of the fluorescence	15
we decided to	15
this protein is	15
acid side chains	15
is considered to	15
high level of	15
context of the	15
inhibitory activity of	15
the response of	15
has been performed	15
potent inhibitor of	15
not only for	15
as they are	15
the composition of	15
shed light on	15
forms of the	15
is to develop	15
of the carbohydrate	15
protein structure modeling	15
monte carlo simulation	15
of the chromophore	15
our aim was	15
a broad range	15
they do not	15
suggested to be	15
nmr spectroscopy and	15
early stages of	15
used to assess	15
and tertiary structures	15
are located in	15
of a human	15
evidence suggests that	15
the de novo	15
impact on the	15
is close to	15
the electron beam	15
absence of the	15
new method for	15
there are no	15
study the effect	15
a tree decomposition	15
protein fold recognition	15
of the trna	15
physicochemical properties of	15
the proteins in	15
of ordered proteins	15
of the self	15
conformation of a	15
structures that are	15
the base of	15
shown in table	15
disruption of the	15
the comparison of	15
supported by a	15
root mean square	15
with the experimental	15
widely used in	15
discussed in the	15
developed a new	15
is the only	15
to form an	15
influence of crystal	15
of great interest	15
is very important	15
that in the	15
a serine protease	15
is shown that	15
at atomic resolution	15
conformational preferences of	15
analyses of the	15
of molecular biology	15
able to inhibit	15
the fi nal	15
the severe acute	15
power of the	15
docking and scoring	15
applications of the	15
an antimicrobial peptide	15
molecule in the	15
this method is	15
c and c	15
level of the	15
an alternative to	15
the antimicrobial activity	15
amber force field	15
molecular dynamics and	15
chains of the	15
the drug discovery	15
able to detect	15
be attributed to	15
a tool for	15
to design a	15
known to bind	15
of the best	15
using molecular dynamics	15
the y e	15
protein of interest	15
necessary for the	15
in our previous	15
taken from the	15
to the native	15
a long time	15
of the results	15
to generate the	15
from the venom	15
investigate the effect	15
to form amyloid	15
to the structural	15
listed in table	15
structures based on	15
showed that a	15
of the basic	15
our data suggest	15
in the final	15
time of the	15
charge of the	15
is compatible with	15
in solution and	15
for design of	15
the presence and	15
are needed to	15
residues that are	15
detected in the	15
the folding process	15
regulated by the	15
giant unilamellar vesicles	15
then used to	15
to distinguish between	15
the partition coefficient	15
result of the	15
critical for the	15
representation of the	15
of the guest	15
which leads to	15
the stabilization of	15
the intensity of	15
evidence for a	15
of which is	15
one of its	15
protein interactions and	15
with the highest	15
we designed and	15
volume of the	15
occur in the	15
to atomic resolution	15
temperature dependence of	15
to a protein	15
from the same	15
in our work	15
the family of	15
functional properties of	15
higher than the	15
of these methods	15
the negatively charged	15
of the ribosome	15
has been solved	15
the maintenance of	15
and mass spectrometry	15
to search for	15
critical assessment of	15
was isolated from	15
with the target	15
the onset of	15
to follow the	15
of the plant	15
the aggregation process	15
proteins from the	15
with experimental data	15
natural amino acids	15
atoms in the	15
value of the	15
the endoplasmic reticulum	15
can be classified	15
this is due	14
of severe acute	14
even in the	14
so as to	14
such as those	14
have been successfully	14
the advantages of	14
tested in vitro	14
of physical chemistry	14
to the corresponding	14
the proliferation of	14
identification of novel	14
of sequence and	14
widely used to	14
destabilization of the	14
the g protein	14
of patients with	14
models have been	14
and the ability	14
structures determined by	14
of conformational changes	14
of the side	14
to the discovery	14
than of the	14
results will be	14
and at the	14
the success of	14
stability of these	14
introduced into the	14
in all the	14
is controlled by	14
and formation of	14
and application of	14
and they are	14
were performed to	14
structure of sars	14
been reported to	14
was observed that	14
identified as a	14
ray structure of	14
contact with the	14
the protein was	14
new family of	14
lies in the	14
instead of the	14
to be in	14
variety of biological	14
in this presentation	14
we have to	14
in biological systems	14
and the n	14
conversion of the	14
but also in	14
the folding and	14
step of the	14
used to generate	14
in the rna	14
amino acid with	14
protein to the	14
may play a	14
analogues of the	14
we hypothesize that	14
a collection of	14
biological activity and	14