quadgram

This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

quadgram	frequency
in the presence of	250
in the case of	127
as well as the	123
the structure of the	122
can be used to	118
on the other hand	106
is one of the	101
one of the most	93
the crystal structure of	82
on the basis of	81
a wide range of	78
in the absence of	77
as a function of	77
an important role in	77
it is possible to	70
for the development of	69
has been shown to	67
a large number of	66
the role of the	66
on the surface of	64
the aim of this	62
for the treatment of	60
was found to be	59
severe acute respiratory syndrome	55
we were able to	55
the protein data bank	55
in the present study	54
in this study we	54
in vitro and in	53
the presence of a	52
a key role in	52
the presence of the	52
crystal structure of the	52
as a result of	51
work was supported by	51
the size of the	51
is based on the	50
the effect of the	49
in this work we	49
solid phase peptide synthesis	49
for the design of	49
vitro and in vivo	49
this work was supported	49
it was found that	48
the nature of the	48
to the formation of	47
play an important role	47
for the synthesis of	46
in the development of	45
the formation of a	44
with respect to the	44
in addition to the	43
for the first time	43
it was shown that	42
the interaction of the	42
to be involved in	41
at the end of	41
the active site of	41
been shown to be	41
of this study was	40
the formation of the	40
were found to be	40
the surface of the	40
has been used to	39
as well as in	39
it has been shown	39
the length of the	39
can be used for	38
the end of the	38
of the amino acid	38
we found that the	38
in the regulation of	38
the stability of the	38
aim of this study	37
this study was to	37
the secondary structure of	37
in the present work	37
for the study of	37
we have shown that	37
have been used to	36
similar to that of	36
in the formation of	36
in the context of	36
plays an important role	35
the analysis of the	35
has been shown that	35
have shown that the	35
we have developed a	34
at the same time	34
by the presence of	34
our results show that	33
vp vp vp vp	33
structure and function of	33
it is important to	33
we show that the	33
was shown to be	33
the development of new	32
these results suggest that	32
can be used as	32
have been shown to	32
to that of the	31
the central nervous system	31
to the presence of	31
in contrast to the	31
results show that the	31
the conformation of the	31
in the range of	31
the mechanism of action	30
the results show that	30
the d structure of	30
a member of the	30
the function of the	30
molecular dynamics simulations of	30
the results of the	30
was used as a	30
crystal structure of a	30
the amino acid sequence	29
that can be used	29
it is known that	29
we have investigated the	29
in a variety of	28
used to determine the	28
mechanism of action of	28
the basis of the	28
of rna secondary structures	28
the influence of the	28
in the field of	27
plays a key role	27
the accuracy of the	27
the development of a	27
a wide variety of	27
the biological activity of	27
we have found that	27
in the treatment of	27
the mechanism of the	27
the importance of the	27
structure and dynamics of	27
the free energy of	26
d structure of the	26
the ability of the	26
the determination of the	26
the structure of a	26
in order to obtain	26
the interaction between the	26
a crucial role in	25
is known to be	25
as well as to	25
a better understanding of	25
better understanding of the	25
the binding of the	25
the use of the	25
of the active site	25
the rest of the	25
for the discovery of	25
can be considered as	25
at the molecular level	25
a new class of	25
it has been suggested	24
using a combination of	24
in order to study	24
is shown in fig	24
in the active site	24
the molecular mechanism of	24
were shown to be	24
the study of the	24
of the target protein	24
to the development of	23
are known to be	23
play a role in	23
the synthesis of the	23
the use of a	23
that there is a	23
in the plasma membrane	23
in order to understand	23
of the secondary structure	23
here we present a	23
aim of this work	23
on the use of	23
as compared to the	22
for the preparation of	22
as well as their	22
crystal structures of the	22
in the number of	22
the position of the	22
a powerful tool for	22
the properties of the	22
our understanding of the	22
of the binding site	22
it is possible that	22
for the detection of	22
of amino acid residues	22
of a series of	22
in order to investigate	22
for the prediction of	21
the side chain of	21
the molecular basis of	21
of the plasma membrane	21
of this study is	21
the majority of the	21
with the aim of	21
the synthesis of a	21
was supported by the	21
can be found in	21
has been suggested that	21
a function of the	21
in order to determine	21
as a model system	21
in the form of	21
can be used in	21
be used as a	21
studies have shown that	21
results suggest that the	21
we have studied the	21
in the identification of	20
in the design of	20
on the structure of	20
little is known about	20
of the most common	20
is due to the	20
in the course of	20
be involved in the	20
the case of the	20
and molecular dynamics simulations	20
with the help of	20
in the central nervous	20
results indicate that the	20
for the formation of	20
the aim of the	20
secondary and tertiary structure	20
of this work is	19
the existence of a	19
our results suggest that	19
design and synthesis of	19
in the process of	19
the crystal structures of	19
the fact that the	19
in the protein data	19
acute respiratory syndrome coronavirus	19
here we report the	19
it is necessary to	19
of the structure of	19
secondary structure of the	19
the structure and dynamics	19
the plasma membrane of	19
for the identification of	19
the changes in the	19
the effects of the	19
structure of the protein	19
the quality of the	19
is a member of	19
in an effort to	19
one of the main	19
the design of new	19
of a number of	19
amino acid sequence of	19
proteins and nucleic acids	18
of the lipid bilayer	18
active site of the	18
the purpose of this	18
used to study the	18
by the formation of	18
a change in the	18
the development of the	18
in the structure of	18
a major role in	18
for the binding of	18
is consistent with the	18
study was to investigate	18
the structures of the	18
in the vicinity of	18
a high degree of	18
with the use of	17
confocal laser scanning microscopy	17
on the analysis of	17
we are able to	17
have been found to	17
at the level of	17
order to understand the	17
the sequence of the	17
de novo design of	17
the regulation of the	17
in the crystal structure	17
play a key role	17
of intrinsic disorder in	17
to the active site	17
the presence of an	17
is responsible for the	17
plays a role in	17
the interactions between the	17
deposited in the pdb	17
to the synthesis of	17
amino acid residues in	17
a role in the	17
it is well known	17
of the crystal structure	17
is crucial for the	17
are involved in the	17
the dynamics of the	17
due to the presence	17
the interaction with the	17
the structure and function	17
have been found in	17
as well as a	17
for their ability to	17
one of the major	16
in a number of	16
of the amino acids	16
to the identification of	16
is well known that	16
a small number of	16
of this work was	16
it was suggested that	16
in agreement with the	16
for the production of	16
by a combination of	16
in order to identify	16
for the determination of	16
the complexity of the	16
has been studied by	16
we are interested in	16
as a basis for	16
the side chains of	16
structural basis for the	16
this work is to	16
to be responsible for	16
to the fact that	16
in an attempt to	16
was found that the	16
in order to find	16
and the number of	16
the results indicate that	16
based on the analysis	16
a critical role in	16
that the presence of	16
the understanding of the	16
for the investigation of	16
can be applied to	16
amino acids in the	16
are responsible for the	16
by means of the	16
and the structure of	16
of the compounds were	16
this study is to	16
in terms of the	16
these results indicate that	16
can be divided into	16
the severe acute respiratory	15
this work was to	15
an essential role in	15
our aim is to	15
binding site of the	15
play a crucial role	15
should be noted that	15
in order to improve	15
for the analysis of	15
study the effect of	15
is believed to be	15
peptides were synthesized by	15
of the most important	15
be considered as a	15
it is shown that	15
rna secondary structure prediction	15
an increase in the	15
was carried out by	15
is related to the	15
be responsible for the	15
and biological activity of	15
the results showed that	15
the molecular mechanisms of	15
was to investigate the	15
the present work we	15
the activity of the	15
was shown that the	15
is thought to be	15
it should be noted	15
key role in the	15
to interact with the	15
on the structure and	15
on the nature of	15
of the mechanism of	15
the formation of an	15
a broad range of	15
the structural and functional	15
the shape of the	15
of the free energy	15
the binding site of	15
be used for the	15
the evaluation of the	15
in vivo and in	15
the discovery of new	14
be related to the	14
our aim was to	14
the drug discovery process	14
of severe acute respiratory	14
as shown in fig	14
able to interact with	14
mode of action of	14
the core of the	14
of a protein is	14
it was observed that	14
in the synthesis of	14
the mechanical properties of	14
than that of the	14
as well as for	14
study was supported by	14
of reactive oxygen species	14
of the human genome	14
the infl uence of	14
of the protein structure	14
understand the role of	14
in the study of	14
influence of crystal packing	14
region of the protein	14
biological activity of the	14
be important for the	14
the identification of a	14
is involved in the	14
of the wild type	14
italian institute of technology	14
it has been proposed	14
to better understand the	14
the morphology of the	14
structure of the complex	14
which can be used	14
to be the most	14
in complex with the	14
the development of novel	14
the resolution of the	14
have the ability to	14
of intrinsically disordered proteins	14
it is believed that	14
during the course of	14
to investigate the effect	14
a new method for	14
is dependent on the	14
have been identified in	14
comparable to that of	14
of a variety of	14
human immunodeficiency virus type	14
the rational design of	13
is likely to be	13
is important for the	13
the vast majority of	13
by nuclear magnetic resonance	13
and structural characterization of	13
by the use of	13
from the venom of	13
the calculation of the	13
in the secondary structure	13
to be able to	13
with a kagome lattice	13
amino acid side chains	13
and the stability of	13
it is likely that	13
in the binding site	13
a homology model of	13
the basis for the	13
it has been concluded	13
in such a way	13
of the protein and	13
the solution structure of	13
this is due to	13
by dynamic light scattering	13
has proven to be	13
is considered to be	13
has been developed for	13
with the active site	13
shown to be a	13
here we present the	13
studied the effect of	13
the location of the	13
be due to the	13
dynamics simulations of the	13
investigate the effect of	13
to be associated with	13
as one of the	13
we have used a	13
the geometry of the	13
to determine whether the	13
in comparison with the	13
that are involved in	13
and nuclear magnetic resonance	13
the organization of the	13
and dynamics of the	13
is shown in figure	13
em structure of the	13
the identification of the	13
it was possible to	13
are characterized by a	13
of peptides and proteins	13
order to investigate the	13
and the use of	13
purpose of this study	13
the results of this	13
is determined by the	13
a model of the	13
we showed that the	13
as well as its	13
a broad spectrum of	13
and can be used	13
investigated the effect of	13
fluorescence resonance energy transfer	13
is required for the	13
and atomic force microscopy	13
the orientation of the	13
of the protein is	13
the application of the	13
of the interaction of	13
of the formation of	13
has emerged as a	12
is the use of	12
as a consequence of	12
a limited number of	12
comparative protein structure modeling	12
and the ability to	12
structure of the peptide	12
we report the synthesis	12
an understanding of the	12
the context of the	12
to be important for	12
has been proposed that	12
this is the first	12
we find that the	12
amino acid sequences of	12
was used as the	12
taking into account the	12
as a starting point	12
its interaction with the	12
the present study we	12
by means of a	12
on the level of	12
has been concluded that	12
is based on a	12
resulted in the identification	12
we have synthesized a	12
order to determine the	12
and the development of	12
the identifi cation of	12
the difference in the	12
to the design of	12
in order to be	12
the details of the	12
the characterization of the	12
the present study was	12
are shown in figure	12
it is difficult to	12
the tertiary structure of	12
has been found to	12
of a set of	12
a kagome lattice structure	12
a new family of	12
for each of the	12
in a way that	12
identification and characterization of	12
a c p c	12
for the purpose of	12
is associated with the	12
used to identify the	12
the amino acid residues	12
were tested for their	12
of the number of	12
our data suggest that	12
structure of the rna	12
was carried out using	12
of the partition coefficient	12
acid residues in the	12
our results indicate that	12
the aim of our	12
to the discovery of	12
vivo and in vitro	12
the assembly of the	12
on the number of	12
the binding affinity of	12
been developed for the	12
have been able to	12
in the pathogenesis of	12
of human immunodeficiency virus	12
in order to develop	12
the binding pocket of	12
in the search for	12
a function of temperature	12
secondary and tertiary structures	12
could be used for	12
the early stages of	12
can also be used	12
at the active site	12
of the presence of	12
a powerful tool to	12
logarithm of the partition	11
to be essential for	11
graphene with a kagome	11
the minor groove of	11
a variety of biological	11
a crystal structure of	11
the number of structures	11
on the type of	11
understanding of the molecular	11
of the effect of	11
and transmission electron microscopy	11
be attributed to the	11
has been widely used	11
have not yet been	11
crucial role in the	11
that the number of	11
have been developed to	11
to the cell surface	11
and characterization of a	11
was used to determine	11
on the mechanism of	11
have been developed for	11
is supported by the	11
seq x and seq	11
plays a crucial role	11
it has been demonstrated	11
presence or absence of	11
are one of the	11
at the plasma membrane	11
by solid phase peptide	11
the viral life cycle	11
performed in order to	11
is a powerful tool	11
are considered to be	11
x and seq y	11
used as a model	11
method is based on	11
sequences seq x and	11
a starting point for	11
the temperature dependence of	11
we report on the	11
it was proposed that	11
based on the use	11
results showed that the	11
have also been used	11
based on these observations	11
a comparison of the	11
the region of the	11
plays a major role	11
on the cell surface	11
an increasing number of	11
in the presence and	11
both in vitro and	11
protein structure and function	11
new insights into the	11
has been applied to	11
understand the mechanism of	11
the course of the	11
the influence of crystal	11
shed light on the	11
that it is possible	11
of a protein structure	11
leads to the formation	11
is similar to that	11
investigate the role of	11
have been used for	11
the plasma membrane and	11
here we show that	11
base pair similarity score	11
could be used to	11
can be related to	11
to study the effect	11
on the secondary structure	11
conformational changes of the	11
is expected to be	11
to the lack of	11
the binding mode of	11
proteins involved in the	11
of the protein in	11
the structural features of	11
the vicinity of the	11
may be used to	11
in order to elucidate	11
on the order of	11
for a long time	11
in good agreement with	11
peptides derived from the	11
has been implicated in	11
in the lipid bilayer	11
vascular endothelial growth factor	11
are based on the	11
and the presence of	11
the difference between the	11
van der waals interactions	11
to understand the role	11
is known about the	11
the presence of two	10
design of amino acid	10
of proteins and nucleic	10
the absence of the	10
of some of these	10
is present in the	10
homology model of the	10
in relation to the	10
which is known to	10
the conformational properties of	10
of the present study	10
structure of the n	10
involved in the formation	10
structure of a human	10
into the active site	10
high affinity for the	10
of rna secondary structure	10
be one of the	10
prepared by solid phase	10
will allow us to	10
fluorescence recovery after photobleaching	10
was supported by grant	10
we have been able	10
is mediated by the	10
for the regulation of	10
organic and biomolecular chemistry	10
that the structure of	10
synthesized a series of	10
be used in the	10
into the mechanism of	10
at the atomic level	10
strongly depends on the	10
the partition coefficient in	10
it has been found	10
play important roles in	10
can be explained by	10
with the aim to	10
we present a new	10
the elucidation of the	10
development of a new	10
and dynamic light scattering	10
structural features of the	10
the spatial distribution of	10
will be discussed in	10
due to the lack	10
been shown that the	10
number of base pairs	10
important role in the	10
the knowledge of the	10
we designed and synthesized	10
the similarity of the	10
be used to determine	10
the surface of a	10
order to study the	10
to investigate the role	10
of the severe acute	10
affi nity for the	10
play an essential role	10
the affinity of the	10
was found in the	10
the kinetics of the	10
when compared to the	10
in the middle of	10
a new approach to	10
we have previously shown	10
report the synthesis of	10
a molecular mass of	10
the low micromolar range	10
and the effect of	10
are a number of	10
of the viral genome	10
the scanning electron microscope	10
as a part of	10
the discovery of novel	10
for the generation of	10
in the binding pocket	10
the presence or absence	10
gives rise to a	10
we have developed an	10
root mean square deviation	10
with the aid of	10
an analysis of the	10
the innate immune system	10
and function of the	10
with a variety of	10
there are a number	10
higher than that of	10
for rna secondary structure	10
is used as a	10
revealed the presence of	10
to bind to the	10
it is also possible	10
to show that the	10
the stability of these	10
to understand the mechanism	10
we focus on the	10
it is clear that	10
can be obtained by	10
the interior of the	10
on the interaction of	10
the mode of action	10
in the activation of	10
conformational changes in the	10
we suggest that the	10
dimensional structure of the	10
in the same way	10
with a number of	10
regions of the protein	10
to those of the	10
the increase of the	10
we will present the	10
to determine the structure	10
has been demonstrated that	10
seems to be a	10
that the use of	10
a potent inhibitor of	10
of the role of	10
are listed in table	10
the base of the	10
to overcome this problem	10
the redox pair dataset	10
the prediction of the	10
the relationship between the	10
and their interactions with	10
the lifetime of the	10
as a template for	10
leading to the formation	10
through the formation of	10
terminal region of the	10
are located in the	10
the increase in the	10
structure of a protein	10
the design of novel	10
with the formation of	10
the release of the	10
for the presence of	10
on the development of	10
the catalytic domain of	10
to the plasma membrane	10
due to the high	10
hungarian academy of sciences	10
with respect to their	10
in order to further	9
play a major role	9
in the control of	9
the evolution of the	9
studied the interaction of	9
by surface plasmon resonance	9
involved in the regulation	9
rna secondary structures with	9
a new approach for	9
be divided into two	9
pharmacology for drug discovery	9
as well as with	9
of the innate immune	9
this suggests that the	9
a web server for	9
which is based on	9
the primary structure of	9
the thermal stability of	9
of the polypeptide chain	9
peptide corresponding to the	9
structure and mechanism of	9
the activation of the	9
investigate the effects of	9
in silico pharmacology for	9
understanding the mechanism of	9
been found to be	9
on the conformation of	9
in the low micromolar	9
school of biological sciences	9
binding site in the	9
of the in vitro	9
in order to test	9
by the addition of	9
a result of the	9
with a series of	9
acid sequence of the	9
a key step in	9
development and application of	9
of a protein to	9
they are involved in	9
may be important for	9
is to investigate the	9
the physical properties of	9
method for the synthesis	9
used to assess the	9
a central role in	9
the binding of a	9
may be related to	9
also be used to	9
are among the most	9
that of the native	9
we focused our attention	9
in the template structure	9
by the eudoc program	9
the goal of this	9
of science and technology	9
to act as a	9
these results show that	9
in the near future	9
the template and target	9
a useful tool for	9
in a range of	9
to be due to	9
the last few years	9
it is unclear whether	9
increase in the number	9
these data suggest that	9
are expected to be	9
on the effect of	9
the base pair similarity	9
the selection of the	9
nuclear magnetic resonance spectroscopy	9
prediction of rna secondary	9
and the role of	9
the s b domain	9
as part of the	9
and in the presence	9
the design and synthesis	9
the presence of different	9
has been found that	9
it is not clear	9
mechanical properties of the	9
were carried out on	9
similar to those of	9
in the absence or	9
from nt to nt	9
one of the first	9
in most of the	9
in the current study	9
used to analyze the	9
of the catalytic domain	9
a decrease in the	9
we present a novel	9
the value of the	9
a large variety of	9
have been characterized by	9
it is based on	9
and the active site	9
methods have been developed	9
in an in vitro	9
the conformational behavior of	9
such a way that	9
this work we have	9
a consequence of the	9
due to the fact	9
to the production of	9
the active site and	9
the concentration of the	9
by the fact that	9
silico pharmacology for drug	9
peptides corresponding to the	9
at different stages of	9
is in agreement with	9
have been proposed to	9
found to be a	9
the distance between the	9
be taken into account	9
we have determined the	9
by atomic force microscopy	9
as well as of	9
the flexibility of the	9
in the last decade	9
were used for the	9
of this type of	9
solid phase synthesis of	9
pseudo amino acid composition	9
are shown in fig	9
the presence of three	9
the efficiency of the	9
carried out using the	9
were carried out using	9
an example of a	9
used in order to	9
the conformation of a	9
the free energy landscape	9
in the viral life	9
the distribution of the	9
in a wide range	9
of protein structure prediction	9
be used to study	9
from the analysis of	9
of the structure and	9
the center of the	9
we focused on the	9
it was concluded that	9
the accessibility of the	9
physical properties of the	9
structures in the pdb	9
is to understand the	9
and its interaction with	9
solved to atomic resolution	9
the application of this	9
we have designed and	9
we conclude that the	9
on the synthesis of	9
the middle of the	9
a model for the	9
the pivot molecule rofecoxib	9
the introduction of the	9
is caused by the	9
in the major groove	9
of the use of	9
the hypothesis that the	9
for protein structure prediction	9
sequence of amino acids	9
were prepared by solid	9
is also possible to	9
the change in the	9
it is essential to	9
the lipid composition of	9
the structural basis of	9
part of the protein	9
of one of the	9
in addition to this	9
focused our attention on	9
is followed by a	8
was carried out to	8
it was demonstrated that	8
with high affinity for	8
russian academy of sciences	8
the composition of the	8
is a powerful technique	8
may be responsible for	8
appears to be a	8
a detailed understanding of	8
plays a critical role	8
the presence of both	8
of the central nervous	8
have been widely used	8
the effect of different	8
of the effects of	8
in order to increase	8
of the peptide chain	8
to the number of	8
on the surfaces of	8
conformational analysis of the	8
in the training set	8
of sequence and structure	8
been applied to the	8
and found that the	8
from the protein data	8
the reduction of the	8
in order to explore	8
by a number of	8
was based on the	8
can serve as a	8
of these peptides to	8
the protein of interest	8
thermal stability of the	8
compared to that of	8
minimum energy conformations of	8
it has also been	8
have proven to be	8
for the case of	8
amino acids of the	8
we have designed a	8
the identity of the	8
base pair similarity scores	8
the prediction of protein	8
the secondary structure and	8
that there is an	8
we describe the synthesis	8
a novel approach to	8
the plasma membrane is	8
makes it possible to	8
understanding of the structure	8
the secondary structures of	8
by solid phase synthesis	8
the dynamics of a	8
were used as a	8
nmr structure of the	8
for scanning electron microscopy	8
it can be used	8
this is the case	8
are close to the	8
a significant role in	8
infl uence on the	8
a large set of	8
for the design and	8
for the construction of	8
the antimicrobial activity of	8
of each amino acid	8
of the binding pocket	8
inhibitors of this enzyme	8
rna secondary and tertiary	8
and the effects of	8
our goal is to	8
structure of the enzyme	8
we present the synthesis	8
the sequence of a	8
it has been reported	8
is part of the	8
have the potential to	8
to the study of	8
be used to predict	8
the protein and the	8
in the outer membrane	8
of the peptide in	8
as the number of	8
which is responsible for	8
and biological evaluation of	8
in spite of the	8
formation of amyloid fibrils	8
used to measure the	8
can be modulated by	8
in the minor groove	8
our results showed that	8
there is evidence that	8
by confocal laser scanning	8
a part of the	8
more than of the	8
coupled folding and binding	8
of proteins in the	8
turned out to be	8
in the concentration of	8
data taken from the	8
studied by means of	8
for the role of	8
good agreement with the	8
may be involved in	8
have been carried out	8
and structural analysis of	8
and differential scanning calorimetry	8
the sum of the	8
institute of physical chemistry	8
a novel class of	8
in the order of	8
to the free energy	8
the past few years	8
the dependence of the	8
order to identify the	8
local structures and functions	8
results of this study	8
ray crystal structure of	8
model of the protein	8
by a variety of	8
other members of the	8
is the number of	8
the guest and host	8
been used to study	8
nmr studies of the	8
the conformational preferences of	8
structure of the sars	8
similar to that observed	8
of a protein can	8
has been determined by	8
as an alternative to	8
we have used the	8
the comparison of the	8
a multiple sequence alignment	8
used to investigate the	8
in our understanding of	8
taking advantage of the	8
the stabilization of the	8
was used for the	8
the mechanism by which	8
drug discovery and development	8
critical role in the	8
with the experimental data	8
we have demonstrated that	8
this study we have	8
method was used to	8
due to its high	8
of the interaction between	8
order to obtain a	8
have designed and synthesized	8
is characterized by a	8
as the sum of	8
it may be possible	8
have been made to	8
in a large number	8
is defined as the	8
taken from the literature	8
can be attributed to	8
on the role of	8
have found that the	8
to be related to	8
with the ability to	8
has led to the	8
showed the presence of	8
of the peptide backbone	8
aided design of amino	8
the first step in	8
we propose that the	8
institute for biophysical chemistry	8
by the lack of	8
structures deposited in the	8
we demonstrate that the	8
have been implicated in	8
aim of the present	8
absence or presence of	8
the results suggest that	8
been solved to atomic	8
in the early s	8
which belongs to the	8
on the formation of	8
on the interaction between	8
the production of a	8
and tertiary structure motifs	8
may be due to	8
to be used as	8
d xz and d	8
of proteins and peptides	8
of action of the	8
play a critical role	8
studies showed that the	8
the binding properties of	8
synthesis and biological activity	8
to the analysis of	8
to be used in	8
the ability of a	8
in the function of	8
considered to be a	8
work is supported by	8
known to be a	8
been used as a	8
we studied the interaction	8
of the local structures	8
a new generation of	8
we observed that the	8
using surface plasmon resonance	8
of the protein chain	8
of a single protein	8
as shown in figure	8
goal of this study	8
a great variety of	8
may contribute to the	8
in the area of	8
the solubility of the	8
close to each other	8
the formation of amyloid	8
that the active site	8
and it has been	8
an attractive target for	8
from the active site	8
on the membrane surface	8
of a range of	8
is a prerequisite for	8
through a series of	8
it is interesting to	8
the observation that the	8
side chains of the	8
for the understanding of	8
us to investigate the	8
on the protein surface	8
a wide spectrum of	8
in the discovery of	8
a new type of	8
a series of peptides	8
proven to be a	8
of the quality of	8
the minimum free energy	8
of the genetic code	8
in the framework of	8
used to monitor the	8
and the formation of	8
have been applied to	8
xz and d yz	8
used to predict the	8
of molecular dynamics simulations	8
have a role in	8
at the base of	8
be explained by the	8
have previously shown that	8
the level of the	8
role in the regulation	8
a wide array of	8
of sequences and structures	8
terminal part of the	8
on the solid support	7
moloney murine leukemia virus	7
are in good agreement	7
for drug discovery s	7
to play a role	7
assumed to be the	7
is limited by the	7
key step in the	7
and dynamics of a	7
to the wild type	7
we also found that	7
the inhibitory effect of	7
structure elements in the	7
it has been recently	7
we will show that	7
with a set of	7
the binding to the	7
in the nucleus and	7
used in combination with	7
on the stability of	7
to fold into a	7
conformational change of the	7
guest and host structures	7
of low molecular weight	7
the presence of this	7
we developed a new	7
the work was supported	7
in the evolution of	7
to play an important	7
as a powerful tool	7
the y e structure	7
of hepatitis c virus	7
of amino acids in	7
is known that the	7
of the enzyme and	7
this indicates that the	7
to the target protein	7
a model system for	7
review is given on	7
the functional properties of	7
make it possible to	7
determine the effect of	7
chemical properties of the	7
of in silico methods	7
docking and molecular dynamics	7
structure and function in	7
is diffi cult to	7
fl uorescent amino acids	7
the results from the	7
of the fact that	7
the molten globule state	7
of in silico pharmacology	7
data show that the	7
based on these results	7
assisted laser desorption ionization	7
is not fully understood	7
deeper understanding of the	7
a potential target for	7
as a target for	7
for the mechanism of	7
of the compounds with	7
is essential for the	7
in order to achieve	7
conformational change in the	7
starting point for the	7
were designed and synthesized	7
peptide was found to	7
was added to the	7
u r n a	7
in the generation of	7
institute for organic and	7
were obtained from the	7
we investigated the effect	7
to the regulation of	7
of the sars coronavirus	7
our data show that	7
tested for their ability	7
and some of them	7
to elucidate the molecular	7
a protein can be	7
that the majority of	7
by molecular dynamics simulations	7
major role in the	7
the peptides were synthesized	7
of the application of	7
that are responsible for	7
the top of the	7
results have shown that	7
an increase of the	7
the structural properties of	7
determine the structure of	7
as well as other	7
to the crystal structure	7
can be represented as	7
in the understanding of	7
of the intrinsically disordered	7
the treatment of the	7
in peptides and proteins	7
we report here the	7
the limited number of	7
of the present work	7
have been identifi ed	7
in this paper we	7
the rna component of	7
across the plasma membrane	7
reported in the literature	7
as well as by	7
structural basis of the	7
in the prediction of	7
to the characterization of	7
the integrity of the	7
activity of the protein	7
and the size of	7
we would like to	7
are taken into account	7
the performance of the	7
data in the literature	7
even in the absence	7
s ekins et al	7
is the result of	7
the green fluorescent protein	7
of glutamic acid residues	7
ray crystal structures of	7
and is responsible for	7
at a molecular level	7
the most commonly used	7
classification of proteins database	7
the number of different	7
the correlation between the	7
when compared with the	7
a l p r	7
structure of the human	7
the amino acid side	7
the statistical significance of	7
the significance of the	7
is given on the	7
the virus spike protein	7
in order to evaluate	7
to form amyloid fibrils	7
state of the art	7
for a set of	7
defined in terms of	7
but also in the	7
been deposited in the	7
essential role in the	7
sequence identity between the	7
the folding of the	7
the recognition of the	7
has been proposed to	7
a new series of	7
to study the interaction	7
of interactions between the	7
see table for references	7
study the interaction of	7
the secondary structure elements	7
there is a growing	7
used a combination of	7
has been carried out	7
r o o f	7
a common feature of	7
for formation of the	7
amino acids at the	7
discovery s ekins et	7
to the existence of	7
the ability to form	7
one of the two	7
to be crucial for	7
have been deposited in	7
central role in the	7
of its interaction with	7
j o u r	7
a fraction of the	7
it is suggested that	7
were synthesized by the	7
model was used to	7
the hydrophobic core of	7
the study of large	7
are related to the	7
the single molecule level	7
to the understanding of	7
to the use of	7
the solid phase synthesis	7
be found in the	7
it is evident that	7
we studied the effect	7
the optimum source neutrons	7
the specificity of the	7
are similar to those	7
than the number of	7
isolated from the venom	7
and is involved in	7
approaches have been developed	7
from the crystal structure	7
if and only if	7
by size exclusion chromatography	7
was used to study	7
in the absence and	7
these findings suggest that	7
for the use of	7
rest of the protein	7
was used to screen	7
unpaired nucleotides in the	7
can be obtained from	7
ministry of science and	7
as a model for	7
is not limited to	7
was supported by rfbr	7
secondary structures with pseudoknots	7
compared to the wild	7
structural classification of proteins	7
of the full length	7
in the asymmetric unit	7
each of the four	7
at the cell surface	7
the redox state of	7
one of the best	7
data suggest that the	7
are a family of	7
based on the crystal	7
we present here a	7
the possible role of	7
max planck institute for	7
o u r n	7
for organic and biomolecular	7
approach was used to	7
be used as an	7
for a variety of	7
the differences between the	7
in the endoplasmic reticulum	7
is very similar to	7
drug discovery s ekins	7
in the cytoplasm and	7
in order to control	7
residues in a protein	7
in order to gain	7
the study of protein	7
a function of time	7
to investigate the effects	7
the interactions of the	7
is attached to the	7
to the structure of	7
were performed using the	7
prior knowledge of the	7
are consistent with the	7
the solution conformation of	7
to test this hypothesis	7
that they can be	7
an integral part of	7
on the properties of	7
through the use of	7
has led to a	7
on the presence of	7
has recently been shown	7
induces the formation of	7
it is not known	7
as the basis for	7
the hydrophobicity of the	7
present the synthesis of	7
l p r e	7
biological processes such as	7
can be classified into	7
the van der waals	7
in silico screening of	7
in our previous study	7
the choice of the	7
g u r e	7
the two types of	7
at the time of	7
rna structure and dynamics	7
in our work we	7
the cell membrane and	7
to be required for	7
affi nity and selectivity	7
lower than that of	7
f i g u	7
based drug design and	7
by transmission electron microscopy	7
takes into account the	7
been proposed to be	7
of the order of	7
of secondary structure elements	7
with the cell membrane	7
is characterized by the	7
copies of a single	7
despite the fact that	7
the binding site for	7
experiments were carried out	7
at the binding site	7
that are able to	7
the starting point for	7
the absence or presence	7
p r o o	7
on the size of	7
this work is supported	7
the plane of the	7
here we report a	7
are found in the	7
and its complex with	7
by means of an	7
as a set of	7
hcv ns b polymerase	7
a combination of the	7
is not able to	7
with a resolution of	7
experimental and computational approaches	7
and characterization of the	7
and the characterization of	7
the results of our	7
have developed a novel	7
using a variety of	7
over a wide range	7
of the target sequence	7
has been used as	7
conformation of the peptide	7
of the transition state	7
provide insight into the	7
for the delivery of	7
free energy of the	7
nucleotides in the junction	7
activity of the compounds	7
of the protein that	7
values of affinity energy	7
state of the protein	7
the investigation of the	7
of the influence of	7
we present a study	7
with the exception of	7
optimum source neutrons energy	7
numbers of positional hits	7
of the sars virus	7
could be used as	7
as a first step	7
been used to determine	7
be used to identify	7
we also studied the	7
phase peptide synthesis and	7
k and na ions	7
as a source of	7
n a l p	7
to a better understanding	7
of the pivot molecule	7
are in agreement with	7
in view of the	7
in the interaction with	7
of a new class	7
interesting to note that	7
conformational changes associated with	7
have been studied in	7
to our understanding of	7
a high level of	7
the molecular details of	7
the design of a	7
in the last years	7
molecular dynamics simulations in	7
sequences that fold into	7
has been developed to	7
has shown that the	7
was to determine the	7
order to improve the	7
led to the discovery	7
was suggested that the	7
supported in part by	7
is very important for	7
amino acid residues that	7
the amino acid sequences	7
the contribution of the	7
i g u r	7
the modulation of the	7
a deeper understanding of	7
site of the enzyme	7
of the cell membrane	7
regulation of gene expression	7
the maintenance of the	7
the goal is to	7
institute of molecular biology	7
absence and presence of	7
a powerful technique for	7
also been shown to	7
by interacting with the	7
infl uence of the	7
hydrophobic core of the	7
study of the interaction	7
play a significant role	7
we are studying the	7
the structure of this	7
on the sequence of	7
the d structures of	7
in the drug discovery	7
r n a l	7
over the past years	6
in the redox pair	6
of at least two	6
the inhibition of the	6
terminus of the protein	6
is close to the	6
that the interaction of	6
are found to be	6
of chemistry and biochemistry	6
the number of base	6
examined the effects of	6
will be presented and	6
is a target for	6
the number of unique	6
structure determination of the	6
of each of the	6
i and j are	6
are of special interest	6
a structural classification of	6
this project is to	6
isolation and characterization of	6
a query sequence and	6
as the size of	6
in sequences seq x	6
it is crucial to	6
formation of the native	6
the proteins in the	6
the quality of a	6
the result of a	6
in part by the	6
the loss of the	6
results will be discussed	6
methods can be used	6
microwave assisted solid phase	6
were calculated based on	6
are likely to be	6
to bridge the gap	6
sequence seq x and	6
in silico prediction of	6
structural analysis of the	6
fluorescence lifetime imaging microscopy	6
were found to inhibit	6
as shown by the	6
to study the effects	6
based on the sequence	6
the lowest free energy	6
and structure of the	6
the small size of	6
a review is given	6
able to inhibit the	6
at the beginning of	6
of which are glutamic	6
directly related to the	6
was estimated to be	6
which leads to the	6
are more likely to	6
can be defined as	6
been shown to play	6
as a tumor suppressor	6
the tip of the	6
due to the small	6
represents one of the	6
lipid composition of the	6
interaction of the peptide	6
the cambridge structural database	6
by the interaction of	6
the atomic resolution structure	6
in the past years	6
has been associated with	6
for the elucidation of	6
which is one of	6
conformational preferences of the	6
can be seen in	6
be essential for the	6
mainly due to the	6
on the observation that	6
p o a c	6
the catalytic activity of	6
study the role of	6
to be critical for	6
the prediction of rna	6
the same way as	6
sars cov main proteinase	6
the activity of a	6
expressed in escherichia coli	6
the early stage of	6
are currently in progress	6
the de novo design	6
features of local structures	6
some of these peptides	6
molecular dynamics simulations and	6
database for the investigation	6
the development of an	6
is widely used for	6
to the prediction of	6
the cellular uptake of	6
amino group of lysine	6
compounds were calculated using	6
optimal structure element alignment	6
is widely accepted that	6
investigated the influence of	6
new light on the	6
atomic structure of the	6
it is easy to	6
the free energies of	6
the amber force field	6
the compounds with the	6
food and drug administration	6
is shown that the	6
the search of new	6
to be important in	6
more likely to be	6
it is widely accepted	6
for the interaction with	6
with the target sequence	6
of the side chains	6
of g s in	6
has been reported in	6
of the large ribosomal	6
to develop a new	6
a large body of	6
nmr and molecular modelling	6
secondary structure in the	6
designed and synthesized a	6
keep in mind that	6
it has recently been	6
the in uence of	6
the construction of a	6
in the preparation of	6
the ph of the	6
the role of this	6
the structural dynamics of	6
in response to the	6
be used to measure	6
is used for the	6
the same as in	6
the protein in the	6
assembled structures formed by	6
we hypothesize that the	6
the residues involved in	6
to be included in	6
of molecular biology and	6
in the folding of	6
which are able to	6
the synthesis of peptides	6
the enzymatic activity of	6
a structural model for	6
the state of the	6
is an indication of	6
have been associated with	6
for a better understanding	6
amino acids and peptides	6
lead to a better	6
of the importance of	6
are of great interest	6
the function of a	6
our attention on the	6
regions of secondary structure	6
solution structure of the	6
based on the structure	6
is directly related to	6
a binding site for	6
characterization of a novel	6
this is consistent with	6
as long as the	6
a novel approach for	6
were observed in the	6
the absence of any	6
different parts of the	6
and there is a	6
steinem institute for organic	6
the ebola virus glycoprotein	6
in a study of	6
protonation states of the	6
in the sense that	6
is the target of	6
partial unfolding of the	6
and the mechanism of	6
by isothermal titration calorimetry	6
led to the development	6
by mass spectrometry and	6
a high number of	6
which is consistent with	6
molecular dynamics simulation of	6
were also found to	6
is part of a	6
water molecules in the	6
presence and in the	6
a protein structure into	6
shown to be essential	6
of the peptide sequence	6
have been investigated by	6
order to evaluate the	6
with a view to	6
with the increase of	6
proteins database for the	6
the activity of these	6
into the role of	6
as a model of	6
also been used to	6
a study of the	6
by fl uorescence spectroscopy	6
as well as some	6
russian foundation for basic	6
we propose a new	6
for each of these	6
has been suggested to	6
ordered and disordered proteins	6
in line with the	6
at the surface of	6
the first step of	6
the purpose of the	6
in the assembly of	6
the number of structure	6
to that of a	6
department of biophysics and	6
was carried out with	6
into the host cell	6
and the lack of	6
a scaffold for the	6
for the recognition of	6
the conversion of the	6
of this project is	6
combined free energy and	6
the formation of protein	6
previous studies have shown	6
with high affinity and	6
insights into the mechanism	6
we show here that	6
biochemistry and molecular biology	6
as an example of	6
shown to play a	6
in health and disease	6
is the synthesis of	6
the latent space of	6
by the introduction of	6
of a large number	6
a unique feature of	6
aim of our study	6
the intensity of the	6
pre to min post	6
which is required for	6
the large ribosomal subunit	6
and isothermal titration calorimetry	6
the solution structures of	6
amino acid residues and	6
were confi rmed by	6
shows an example of	6
the destabilization of the	6
between local structures and	6
of the proteins in	6
changes in secondary structure	6
of these two proteins	6
is an example of	6
in response to environmental	6
in a previous study	6
in the early stages	6
in the light of	6
structural and functional studies	6
and stability of the	6
there is still a	6
in contrast to other	6
has also been used	6
and scanning electron microscopy	6
ability to cross the	6
in the second sequence	6
there are glutamic acids	6
the multimeric host system	6
in order to better	6
the outer membrane of	6
to obtain information on	6
first crystal structure of	6
presence and absence of	6
is very different from	6
is formed by the	6
a number of studies	6
the design of the	6
proteins that have been	6
of biologically active peptides	6
need to be considered	6
in the transmembrane region	6
on a set of	6
a novel type of	6
it seems to be	6
to interfere with the	6
in solid phase peptide	6
the compounds were calculated	6
to one of the	6
crystal structure of human	6
investigation of sequences and	6
using molecular dynamics simulations	6
for the characterization of	6
on a molecular level	6
an important step in	6
a novel method for	6
idprs are characterized by	6
and a number of	6
that the ability of	6
of the binding sites	6
allowed us to identify	6
crystal structures of small	6
withdrawing power of the	6
tertiary structure of the	6
amino acids can be	6
it is proposed that	6
due to the complexity	6
and compared with the	6
is illustrated in fig	6
the first time that	6
to investigate the structural	6
one of the three	6
will be used to	6
on the set of	6
as well as on	6
active site and the	6
investigated the effects of	6
is a key step	6
in the majority of	6
a single amino acid	6
to a set of	6
studies were carried out	6
on the cell membrane	6
for the activation of	6
the large number of	6
the human genome project	6
the presence and in	6
are able to bind	6
regression equations were calculated	6
the mott cross section	6
series of analogues of	6
the absence and presence	6
is a highly conserved	6
presence of negatively charged	6
a large amount of	6
and small angle x	6
by using a combination	6
this region of the	6
to the complexity of	6
to the action of	6
the elastic modulus of	6
plays a central role	6
of education and science	6
of protein secondary structure	6
slovak academy of sciences	6
in order to verify	6
are predicted to be	6
at the site of	6
structural biology in antiviral	6
applied to study the	6
of the ion channel	6
the ways in which	6
structure has been determined	6
developed a method to	6
single molecule force spectroscopy	6
the origin of the	6
types of amino acids	6
in contact with the	6
intrinsic fluorescence of the	6
the active site residues	6
the action of the	6
here we describe the	6
in antiviral drug discovery	6
the effects of mutations	6
the intermolecular interaction energy	6
be applied to the	6
is the fi rst	6
to the loss of	6
structure of an rna	6
in the liver and	6
proteins that are involved	6
properties of the membrane	6
there is a need	6
organization and dynamics of	6
the effects of different	6
a component of the	6
the dissociation of the	6
an important class of	6
the width of the	6
linear and cyclic peptides	6
anthology of intrinsic disorder	6
there is an urgent	6
and van der waals	6
for a range of	6
with that of the	6
the active site is	6
the basis of a	6
of the selected compounds	6
designed a series of	6
to a large extent	6
is supported by a	6
to elucidate the role	6
amino acid in the	6
umbilical vein endothelial cells	6
based on the observation	6
lead to the formation	6
studies have demonstrated that	6
results in the formation	6
which are known to	6
to determine the effect	6
carried out with the	6
in the conformation of	6
development of a novel	6
as a model to	6
amino acids that are	6
the best of our	6
in this study were	6
insight into the molecular	6
on the aggregation of	6
is controlled by the	6
amino acid composition of	6
a representative set of	6
the results of these	6
binding mode of the	6
in all of the	6
as well as an	6
the results demonstrate that	6
of the folding process	6
peptide synthesis in water	6
the preparation of the	6
best of our knowledge	6
the lipid bilayer of	6
out of the helix	6
were calculated for the	6
of the photosynthetic apparatus	6
the replacement of the	6
of water molecules in	6
with a diameter of	6
made it possible to	6
are located within the	6
drude polarizable force field	6
a measure of the	6
were synthesized and tested	6
is composed of three	6
comparative analysis of the	6
dimensional structures of proteins	6
is regulated by the	6
is able to interact	6
peptides were prepared by	6
conformations of the compounds	6
in comparison to the	6
present study was to	6
bridge the gap between	6
requires the presence of	6
can be studied by	6
department of chemistry and	6
synthesized by the solid	6
the ability to bind	6
for the separation of	6
has allowed us to	6
are believed to be	6
the differences in the	6
of amino acids with	6
the lipid bilayer and	6
and is associated with	6
has also been suggested	6
data were collected at	6
has a number of	6
analyzed in terms of	6
increasing evidence suggests that	6
plays an essential role	6
of secondary structure in	6
of these peptides in	6
the removal of the	6
the volume of the	6
we have previously reported	6
was applied to the	6
the residues in the	6
may be regarded as	6
in the human genome	6
small angle neutron scattering	6
in terms of their	6
signal to noise ratio	6
to the family of	6
without prior knowledge of	6
some of them are	6
atom molecular dynamics simulations	6
on the ability of	6
an extension of the	6
approaches have been used	6
we are investigating the	6
and has been shown	6
in the interior of	6
nucleic acids in solution	6
biology in antiviral drug	6
and fluorescence correlation spectroscopy	6
for the selection of	6
of the simulation time	6
and analysis of the	6
from the fact that	6
of amino acids that	6
is an urgent need	6
at the interface between	6
as a tool for	6
in the latent space	6
agreement with experimental data	6
activity as well as	6
of one or more	6
phase ii clinical trials	6
on the rate of	6
the role of these	6
a and b are	6
by fluorescence correlation spectroscopy	6
inhibit the growth of	6
the decrease of the	6
have been synthesized and	6
known to be involved	6
the first crystal structure	6
been widely used to	6
was then used to	6
a dynamic programming algorithm	6
to that observed in	6
to the best of	6
functional anthology of intrinsic	6
further our understanding of	6
to be one of	6
the magnitude of the	6
different from that of	6
binding sites in the	6
the structural basis for	6
to a resolution of	6
have been recognized as	6
is unclear whether the	6
to its ability to	6
of the membrane and	6
which has been shown	6
the dimensions of the	6
web server for the	6
for a series of	6
is represented by a	6
in the first sequence	6
ministry of education and	6
recent studies have shown	6
has been observed in	6
has the advantage of	6
the human immunodeficiency virus	6
from amino acid sequence	6
the peptide backbone and	6
size and distance cutoff	6
of the nature of	6
was attributed to the	6
a fundamental role in	6
in the past few	6
protein misfolding and aggregation	6
used for the treatment	6
the potential use of	6
and in the absence	6
here we report on	6
very similar to that	6
been identified in the	6
of this approach is	6
is critical for the	6
the wild type and	6
was observed in the	6
of this paper is	6
the development of peptide	6
it is not surprising	6
of nucleic acid drugs	6
molecular dynamics simulations were	6
we have also observed	6
that the position of	6
the use of this	6
the active sites of	6
we have also performed	6
these results provide a	6
the interface between the	6
in the first step	6
binding sites of the	6
the search for new	6
in the solid state	6
for transmission electron microscopy	6
and selectivity of the	6
at different spatial scales	6
an important component of	6
of the proteins were	6
assisted solid phase peptide	6
binding sites in proteins	6
in the determination of	6
studies revealed that the	6
are used in the	6
the ligand to the	6
were consistent with the	6
the effect of these	6
of protein intrinsic disorder	6
the number of possible	6
ligand binding to the	6
the investigation of sequences	6
folding and stability of	6
to the stability of	6
of cell biology and	6
of the viral rna	6
as a tool to	6
we have measured the	6
comparative modeling and ligand	6
play key roles in	6
amino acids in positions	6
the number of known	6
human umbilical vein endothelial	6
our results demonstrate that	6
is the ability to	6
the presence of mm	6
human islet amyloid polypeptide	6
may play a role	6
the main goal of	6
well as in the	6
the introduction of a	6
to the surface of	6
that the binding of	6
free energy and similarity	6
basis for design of	6
the generation of a	6
order to elucidate the	6
we believe that the	6
intrinsically disordered proteins in	6
in terms of sensitivity	6
be included in the	6
is of particular interest	6
to investigate the structure	6
in the previous section	6
is composed of a	6
have been successfully used	6
in supplementary table s	6
and the structures of	6
and d yz orbitals	6
the protonation states of	6
the presence of ca	6
are important for the	6
referred to as the	6
we have recently shown	6
described in the literature	6
may be possible to	6
believed to play a	6
high performance liquid chromatography	6
of proteins database for	6
the standard energy model	6
ph and ionic strength	6
power of the substituent	5
the biophysical properties of	5
using a set of	5
this work we report	5
of the interactions between	5
be used to detect	5
drug design using catalyst	5
confocal laser scanning microscope	5
the catalytic mechanism of	5
between a query sequence	5
the sensitivity of the	5
involved in regulation of	5
of the backbone atoms	5
the structure can be	5
has been identified as	5
a key regulator of	5
at an early stage	5
to be a key	5
the role played by	5
of the extracellular matrix	5
the cyp c crystallographic	5
order to obtain the	5
site of the protein	5
it is also known	5
rna polymerase of poliovirus	5
an example of this	5
glutamic and aspartic acids	5
to the pivot compound	5
we believe that these	5
in this poster we	5
a correlation between the	5
at a rate of	5
will be able to	5
the intrinsic fluorescence of	5
we have developed new	5
the single molecular level	5
second part of the	5
phase peptide synthesis method	5
template and target proteins	5
of protein structure by	5
acid residue in position	5
lipid bilayer of the	5
experiments have shown that	5
in the amino acid	5
the enzyme active site	5
study we investigated the	5
studies were performed with	5
a significant fraction of	5
and surface plasmon resonance	5
using transmission electron microscopy	5
role in stabilizing the	5
and optimisation of new	5
found to be the	5
also known as the	5
the metabolic stability of	5
results will be presented	5
and biological properties of	5
as the presence of	5
we have recently developed	5
and lmqc structures are	5
the importance of a	5
small molecule inhibitors of	5
can be done by	5
structural changes in the	5
spatial and temporal resolution	5
the functioning of the	5
were synthesized by fmoc	5
three domains of life	5
region of the spectrum	5
were performed in order	5
idps idprs are characterized	5
in the brain and	5
can be described as	5
it is responsible for	5
but little is known	5
for its ability to	5
according to the following	5
both in the presence	5
the objective of the	5
can be determined by	5
in regulation of the	5
been successfully used to	5
residues in this region	5
parallel to the membrane	5
which are found in	5
the tree width of	5
the global optimal threading	5
stability of a protein	5
in addition to their	5
will be used in	5
the time evolution of	5
is used in the	5
been suggested to be	5
used to calculate the	5
found to be active	5
are involved in a	5
when it comes to	5
the molecular mechanisms underlying	5
similar to those reported	5
very different from the	5
a variety of cellular	5
the same amino acid	5
they are able to	5
of the most effective	5
all over the world	5
of the s b	5
to the binding site	5
there is currently no	5
in order to characterize	5
as the starting point	5
take place in the	5
by their ability to	5
as a measure of	5
virtual screening of chemical	5
analysis of the crystal	5
less than sequence identity	5
of isothermal titration calorimetry	5
this study we present	5
is the design of	5
and the nature of	5
simulations in order to	5
one of the four	5
in the electron microscope	5
that the degree of	5
electrostatic interactions between the	5
of the double helix	5
to distinguish between the	5
in a loss of	5
hydrogen bonding and stacking	5
was observed for the	5
reproduce crystal structures of	5
as shown in table	5
the beginning of the	5
of this protein in	5
drug discovery bassetto et	5
with those of the	5
the stiffness of the	5
aim of our work	5
activity of the peptides	5
to the g protein	5
peptides are able to	5
from the structure of	5
of unique structural folds	5
for the detection and	5
for most of the	5
supported by the russian	5
and is required for	5
are used for the	5
an indication of the	5
the synthesis and the	5
with the viral rna	5
spatial distribution of the	5
is located at the	5
are known to have	5
we designed a series	5
must be able to	5
one of which is	5
investigate the influence of	5
the total number of	5
could be considered as	5
of the binding partners	5
energy and similarity score	5
comparison of rna secondary	5
is the presence of	5
only a small number	5
of these peptides are	5
order to better understand	5
the best results were	5
using atomic force microscopy	5
the entire sequence space	5
function of the protein	5
have been developed in	5
we report the results	5
in the last decades	5
to a variety of	5
ochratoxin a and b	5
has been identified in	5
studies have revealed that	5
to understand the molecular	5
the application of a	5
because of their high	5
crystal structure of sars	5
a major challenge in	5
to the membrane surface	5
of the structure can	5
to a range of	5
for a large number	5
the structure of griffithsin	5
the structure analysis component	5
the case of a	5
a set of different	5
their ability to inhibit	5
em structure of human	5
to be much more	5
study revealed that the	5
also been implicated in	5
the biological activity and	5
screened rutherford cross section	5
the discovery of a	5
is more stable than	5
searching for drug design	5
to further understand the	5
for the interaction of	5
the superposition of the	5
target for the development	5
the main components of	5
there is an increasing	5
a major limitation of	5
and the design of	5
of the interactions of	5
powerful tool for the	5
at different ph values	5
each of the three	5
present work we have	5
of a lipid bilayer	5
beyond the diffraction limit	5
that the eudoc program	5
and the determination of	5
the catalytic cycle of	5
the cyclic cystine knot	5
their mechanism of action	5