This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-283491-y6t64pux | How good are my data and what is the resolution? |
| cord-003020-q69f57el | Why OppA protein can bind sequence- independent peptides? |
| cord-171099-d0qr84xg | A series of PDB related databases for everyday needs Structure and stability of the lamin A tail domain and HGPS mutant Evaluating Hierarchical Structure in Music Annotations Sounds interesting: can sonification help us design new proteins? |
| cord-002490-kw8psrmz | How do filovirus filaments bend without breaking? |
| cord-322885-ob5euspo | Gold mine or just a bigger haystack? |
| cord-103823-3rchp9yy | In other words, RNAVLab helps scientists to address questions such as''what are the mechanisms of nodavirus RNA replication?". |
| cord-009660-23cdi61w | : Finely minced fresh tumor biopsy material was placed in glass T flasks under perforated cellophane membrane antl incubated in Ham's FIO medium containing 20% heat inactivated fetal calf serum, penicillin G? |
| cord-346546-yffwd0dc | How Significant Are Unusual 660 Protein- Ligand Interactions? |
| cord-346965-0oq2n0af | Protein clefts in molecular recognition and function From protein structure to biochemical function? |
| cord-254107-02bik024 | Are homology models of G- protein- coupled receptors suitable targets? |
| cord-329102-2y49kcwu | Transcriptome Global or local? |
| cord-264489-h1n9ywbd | does water mediate sequence- specific binding at the DNA primary- kink site? |
| cord-329504-91te3nu8 | Why were just over half of all reflections that could have been measured at this resolution recorded? |
| cord-330590-nu8ckeud | A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-018401-josb16pi | The"correctly- folded"state of proteins: Is it a metastable state? |
| cord-018401-josb16pi | molecular recognition of paraoxon in Langmuir films Influence of pH and pyrenyl on the structural and morphological control of peptide nanotubes Bioorganic chemistry Neurotoxic effects of thioflavin S- positive amyloid deposits in transgenic mice and Alzheimer's disease Is congo red an amyloid- specific dye? |
| cord-002015-s3tdllby | Lehman N. Spontaneous network formation among cooperative RNA replicators Beta- sheet topology and the relatedness of proteins Are there knots in proteins? |
| cord-002015-s3tdllby | Some new twists Probability of DNA knotting and the effective diameter of the DNA double helix DNA knots reveal a chiral organization of DNA in phage capsids Knotting of a DNA chain during ring closure Absence of knots in known RNA structures To knot or not to knot? |
| cord-292483-u0ycqelc | How well does the map correspond to original experimental images( Baker et al., 1999)? |
| cord-292483-u0ycqelc | What is its resolution( I/ s(I) as a function of resolution)? |
| cord-263017-rh86g4jk | and how do these vary amongst different strains and species; 2) What specific chemical modifications take place in the genome and capsid during disinfection and what effects do these modifications have on virus structure and function; 3) How similar are disinfectant- induced modifications amongst various enteric viruses? |
| cord-263017-rh86g4jk | how important are chloramine transfer reactions and protein tertiary structure? |
| cord-270587-k56fze59 | Lewisx Benefits from a Nonconventional C- H···O Hydrogen Bond Is N- acetyl- d- glucosamine a rigid 4C1 chair? |
| cord-270587-k56fze59 | So you think computational approaches to understanding glycosaminoglycan- protein interactions are too dry and too rigid? |
| cord-266921-x9q7dwc4 | Are there dedicated, highly specific nucleases that do this controlled trimming? |
| cord-266921-x9q7dwc4 | Conversely, how are unstructured or damaged RNAs identified and turned over? |
| cord-266921-x9q7dwc4 | how do cells maintain folded RNA structures, such as tRNA and ribosomes, in the presence of all these keen ribonucleases? |
| cord-313694-p2sgaypq | Decreased transfer of oligosaccharide from oligosaccharideqipid to protein acceptors in regenerating rat liver Stimulation of lipid- linked oligosaccharide assembly duing oviduct differentiation Cell- type- related segregation of surface galactosyl- containing components at an early developmental stage in hemopoietic bone marrow cells in the rabbit Changes in asparagine- linked sugar chains of human promyelocytic leukemic cells( HL-60) during monocytoid differentiation and myeloid differentiation Are glycoproteins and glycosaminoglycans components of the eukaryotic genome? |
| cord-313694-p2sgaypq | The accesibility to trypsin of the susceptible bonds in ovine submaxillary land mucoproteins Influenza C virus uses 9- 0-Acetyl- N- Acetylneuraminic Acid as a high affinity receptor determinant for attachment to cells Carbohydrate- binding sites of the mannose- specific fimbrial lectins of enterobacteria The mouse egg's receptor for sperm; What is it and how does it work? |
| cord-013387-q91052qw | Towards prediction paradise? |
| cord-013387-q91052qw | What Is Known and What Is Next? |
| cord-023208-w99gc5nx | Are aza- β3 amino acids γ- turn mimetics? |
| cord-023208-w99gc5nx | These cells were multilayered on day-3 and expressed various keratinocyte markers, including cytokeratin-1, involculin, and laminin? |
| cord-017181-ywz6w2po | Structure Distribution- Is the equilibrium ratio between minimum free energy( mfe) and suboptimal structures as expected? |
| cord-017181-ywz6w2po | Structure Refolding- Are molecules able to refold from suboptimal to more stable structural conformations? |
| cord-017181-ywz6w2po | Three different types of experiments were done: Native Structure- Correlates the majority of formed structures with the native structure after sufficient long simulation time? |
| cord-031957-df4luh5v | Rapid and sensitive sequence comparison with FASTP and FASTA Comparative analysis of the quality of a global algorithm and a local algorithm for alignment of two sequences Programming techniques: regular expression search algorithm Profile hidden Markov models Hidden Markov models and their applications in biological sequence analysis What are the ideal properties for functional food peptides with antihypertensive effect? |
| cord-031957-df4luh5v | parvifolia Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature? |
| cord-031957-df4luh5v | pore formers or metabolic inhibitors in bacteria? |
| cord-023284-i0ecxgus | ( Asn- Ala- Asn- Pro) which is a major immunogenic epitope in the circumsporozoite( CS) protein of Plasmodium falciparum Conformational analysis Dream or reality? |
| cord-023284-i0ecxgus | Metalloproteins as chemoreceptors? |
| cord-023284-i0ecxgus | The program system allows for SCF level treatments of energy, first- and second- order derivatives with respect to nuclear coordinates, and an evaluation of the ME? |
| cord-252166-qah877pk | A return to rational drug discovery: computer- based models of cells, organs and systems in drug target identification Homology modeling of the serotonin 5-HT1A receptor using automated docking of bioactive compounds with defined geometry Computational tools for the analysis and visualization of multiple protein- ligand complexes Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases? |
| cord-252166-qah877pk | Can we estimate the accuracy of ADME- Tox predictions? |
| cord-252166-qah877pk | More broadly, will in silico pharmacology ever be able to replace entirely experimental approaches in vitro and even in vivo, as some animal rights activists want us to believe? |
| cord-252166-qah877pk | While we are seeing a closer interaction between computational and in vitro approaches to date, will we see a similar relationship with in vivo studies in the future? |
| cord-310847-63gh2tg4 | Structural analysis of the Bacillus subtilis delta factor: a protein polyanion which displaces RNA from RNA polymerase MARCKS: a case of molecular exaptation? |
| cord-310847-63gh2tg4 | Why are"natively unfolded"proteins unstructured under physiologic conditions? |
| cord-310847-63gh2tg4 | an ancient posttranslational modification Polyglutamylation: a fine- regulator of protein function?' |
| cord-304794-z2kx314h | Dr Jekyll or Mr Hyde? |
| cord-304794-z2kx314h | The Bloom's syndrome helicase unwinds G4 DNA Genome- wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability Human papillomavirus G- quadruplexes Spectrum of Epstein- Barr virus- associated diseases Role for G- quadruplex RNA binding by Epstein- Barr virus nuclear antigen 1 in DNA replication and metaphase chromosome attachment G- quadruplexes regulate Epstein- Barr virus- encoded nuclear antigen 1 mRNA translation Targeting G- quadruplexes in gene promoters: a novel anticancer strategy? |
| cord-304794-z2kx314h | The guanine- quadruplex aptamer 93del inhibits HIV-1 replication ex vivo by interfering with viral entry, reverse transcription and integration Cellular uptake of ODNs in HIV-1 human- infected cells: a role for viral particles in DNA delivery? |
| cord-014685-ihh30q6f | How important is protein exibility for transport through ion channels? |
| cord-014685-ihh30q6f | Should it be the autonomous course or the part of physiology and radiology courses in the problem based learning approach?! |
| cord-014685-ihh30q6f | The consistency in the formations of these conformations makes the design of peptides with alpha, beta? |
| cord-014685-ihh30q6f | a tug- ofwar or coordinated movement? |
| cord-257494-242k58ll | : How far are we? |
| cord-257494-242k58ll | In light of this scarce resistance mechanisms de novo acquisition, what mechanisms do bacteria naturally develop/ possess against ABPs? |
| cord-257494-242k58ll | Pore formers or metabolic inhibitors in bacteria? |
| cord-257494-242k58ll | Structural relationship between human salivary histatins Zinc and copper bind to unique sites of histatin 5 Is salivary histatin 5 a metallopeptide? |
| cord-010260-8lnpujip | Consensus regions with preferred conformation in homologous proteins Prediction of protein secondary structure at better than 70% accuracy Secondary structure prediction of all- helical proteins in two states PHD-An automatic mail server for protein secondary structure prediction Progress in protein structure prediction? |
| cord-010260-8lnpujip | How can these cases be identified in a reliable way? |
| cord-010260-8lnpujip | How do serine proteases really work? |
| cord-010260-8lnpujip | Predicting protein secondary structure with a nearest- neighbor algorithm Database of homologyderived protein structures and the structural meaning of sequence alignment An winexpensive, versatile sample illuminator for photo- CIDNP on any NMR spectrometer Pancreatic lipases: Evolutionary intermediates in a positional change of catalytic carboxylates? |
| cord-010260-8lnpujip | Some central questions arise: Do we know enough to undertake such tasks, and what goals can we define? |
| cord-010260-8lnpujip | Will future computers be all wet? |
| cord-282035-jibmg4ch | Do birds of a feather flock together? |
| cord-282035-jibmg4ch | How many faces do people know? |
| cord-282035-jibmg4ch | The effects of local spatial structure on epidemiological invasions Dynamic social networks and the implications for the spread of infectious disease Social encounter networks: characterizing Great Britain Social mixing patterns in rural and urban areas of southern China Household structure and infectious disease transmission Threshold parameters for a model of epidemic spread among households and workplaces Bondedness and sociality Close social associations in animals and humans: functions and mechanisms of friendship Measuring patterns of acquaintanceship Social network size in humans Exploring variations in active network size: constraints and ego characteristics Activity in social media and intimacy in social relationships Calling Dunbar's numbers Comparative analysis of layered structures in empirical investor networks and cellphone communication networks From 150 to 3: Dunbar's numbers Communication dynamics in finite capacity social networks Do online social media cut through the constraints that limit the size of offline social networks? |
| cord-282035-jibmg4ch | The relationship between similarity and altruism in social networks Birds of a feather: homophily in social networks Altruism in social networks: evidence for a'kinship premium'Gender homophily in online dyadic and triadic relationships Playing with strangers: which shared traits attract us most to new people? |
| cord-282035-jibmg4ch | Why are there so many explanations for primate brain evolution? |
| cord-282035-jibmg4ch | [ 85] differentiated, on the basis of calling patterns, two distinct phenotypes:'social keepers'who focused their calls on a small, stable cohort of contacts( introverts?) and'social explorers'who had a larger number of contacts with high churn( social butterflies, or extraverts?). |
| cord-282035-jibmg4ch | [ 85] differentiated, on the basis of calling patterns, two distinct phenotypes:'social keepers'who focused their calls on a small, stable cohort of contacts( introverts?) and'social explorers'who had a larger number of contacts with high churn( social butterflies, or extraverts?). |
| cord-023209-un2ysc2v | And, is Abeta modifi ed by 1( 2) able to aggregate at low concentrations on a biologically relevant time scale? |
| cord-023209-un2ysc2v | Because these compounds were rationally designed by using the co- crystallized structure of VEGF with the immunoglobulin like fragment 2 of VEGFR-1, we raise the following question: do these antagonists really target the immunoglobulin like domain 2 of VEGFR-1? |
| cord-023209-un2ysc2v | C more or less resistant to denaturation conditions? |
| cord-023209-un2ysc2v | Conformational preferences of investigated systems were obtained on base of ROESY and NOESY experiments and calculations by use of X- PLOR and quantum chemical calculation Is concentration overload or volume overload the best strategy for synthetic peptide purifi cation? |
| cord-023209-un2ysc2v | Peptido2.rotaxanes: can a tetramide macrocycle travel to a station by wrapping up around a helical peptide thread? |
| cord-023209-un2ysc2v | lower the CC of Abeta aggregation into the PC range? |
| cord-018963-2lia97db | A fit well with structural fold B? |
| cord-018963-2lia97db | A fit well with structural fold B? |
| cord-018963-2lia97db | A unified statistical framework for sequence comparison and structure comparison Emergence of preferred structures in a simple model of protein folding Are protein folds atypical? |
| cord-018963-2lia97db | Bioinformatics in the driver's seat Prediction of transcription regulatory sites in Archaea by a comparative genomic approach Can sequence determine function? |
| cord-018963-2lia97db | How representative are the known structures of the proteins in a complete genome? |
| cord-018963-2lia97db | This observation has also raised an interesting question:"Is there something special about the topology of protein structures, which could be further and more rigorously exploited for efficient threading algorithm development?" |
| cord-018963-2lia97db | Why do globular proteins fit the limited set of folding patterns? |
| cord-351222-9bfchw4u | A marine natural product database Combining ethnopharmacology and virtual screening for lead structure discovery: COX- inhibitors as application example Computer- aided molecular selection and design of natural bioactive molecules Phytochemical databases of Chinese herbal constituents and bioactive plant compounds with known target specifities Strategies for efficient lead structure discovery from natural products Integrated in silico tools to exploit the natural products'bioactivity ADMET in silico modelling: towards prediction paradise? |
| cord-351222-9bfchw4u | Advances in drug research? |
| cord-351222-9bfchw4u | Drug research? |
| cord-351222-9bfchw4u | How does consensus scoring work for virtual library screening? |
| cord-351222-9bfchw4u | Molecular docking and high- throughput screening for novel inhibitors of protein tyrosine phosphatase-1B Rational selection of structurally diverse natural product scaffolds with favorable ADME properties for drug discovery Drugs? |
| cord-351222-9bfchw4u | The impact of informatics and computational chemistry on synthesis and screening Virtual screening: an effective tool for lead structure discovery? |
| cord-351222-9bfchw4u | Which in vitro screens guide the prediction of oral absorption and volume of distribution? |
| cord-004534-jqm1hxps | -Single molecule biophysics- Is there a specific erythrocyte membrane receptor for fibrinogen? |
| cord-004534-jqm1hxps | A generalized quantitative FRAP method with no restriction on the size of the photobleached area Heterochromatin protein 1 in DNA damage response-recruitment or dissociation from repair sites? |
| cord-004534-jqm1hxps | Application of the methodology to binding of various aromatic drugs with DNA provides an answer to the question'What forces are the main contributors to the stabilization of aromatic ligand- DNA complexes'? |
| cord-004534-jqm1hxps | Do retinal rod outer segments carry out oxydative phosphorylation? |
| cord-004534-jqm1hxps | Does the lysosomal membrane need triglycerides? |
| cord-004534-jqm1hxps | What about the force? |
| cord-004534-jqm1hxps | pN. Pushing on microtubules: dominant spindle centering mechanism in C. elegans embryo? |
| cord-023442-4vzwc2d2 | Does the item infringe upon a U.S. patent? |
| cord-023442-4vzwc2d2 | How will we know which shipments of EPROMs should be excluded from entry into the U.S.? |
| cord-023442-4vzwc2d2 | If a single, very small paint particle is found on the jeans of a pedestrian struck in a hit- and- run accident, could the particle be from the striking vehicle, or merely from the roadway debris at the scene? |
| cord-023442-4vzwc2d2 | Is the item correctly described? |
| cord-023442-4vzwc2d2 | The most common question requested by investigators was"How long had the syringe been in the soft drink can?" |
| cord-023442-4vzwc2d2 | What is the item? |
| cord-023442-4vzwc2d2 | if naked, what is its size, and does it have distinguishing capsid( outer) markings; if enveloped, does it have visible spikes or fuzz around the outside; what is its size, and is the nucleocapsid( the core) visible in particles that have been penetrated by stain; what is the shape of the nucleocapsid, if visible? |
| cord-008588-4eu9v5d3 | An important question not yet satisfactorily answered is: Which distances and torsion angles must be measured with what accuracy to specify a three- dimensional structure for RNA molecules? |
| cord-008588-4eu9v5d3 | Can unpaired nucleotides in all of the secondary structure loop types engage in tertiary pairing? |
| cord-008588-4eu9v5d3 | Do the surrounding base- pairs break to form an internal loop instead of a bulge? |
| cord-008588-4eu9v5d3 | Does a single base bulge that is looped out of the helix create a bend? |
| cord-008588-4eu9v5d3 | Finally, the effects of symmetrical and asymmetrical internal loops on the sugar- phosphate backbone must be explored: Do bends occur at internal loops? |
| cord-008588-4eu9v5d3 | For example, from the cloverleaf secondary structure of tRNA, how would the algorithm know that the junction conformation brings the D loop close to the T loop, but not to the anticodon loop? |
| cord-008588-4eu9v5d3 | How much does a bulge bend or kink the helix? |
| cord-008588-4eu9v5d3 | The main structural questions of interest are:( 1) Does one unpaired base intercalate into the helix, or is it extrahelical, with the base- pairs on either side stacked on each other? |
| cord-008588-4eu9v5d3 | What is the effect of very large bulge loops? |
| cord-301827-a7hnuxy5 | A polypeptide chain at the folding- misfolding- nonfolding cross- roads: which way to go? |
| cord-301827-a7hnuxy5 | How can one develop tissue- specific drugs targeting such abundant proteins? |
| cord-301827-a7hnuxy5 | Polyglutamine diseases: a transcription disorder? |
| cord-301827-a7hnuxy5 | Prevalent structural disorder in E. coli and S. cerevisiae proteomes Large- scale analysis of thermostable, mammalian proteins provides insights into the intrinsically disordered proteome Archaic chaos: intrinsically disordered proteins in Archaea Reduction in structural disorder and functional complexity in the thermal adaptation of prokaryotes Intrinsic disorder in pathogenic and non- pathogenic microbes: discovering and analyzing the unfoldomes of early- branching eukaryotes How much of protein sequence space has been explored by life on Earth? |
| cord-301827-a7hnuxy5 | Regular arrangement on the peptidoglycan and unusual dodecyl sulfate binding Proposed knobs- intoholes packing for several membrane proteins Folding patterns of porin and bacteriorhodopsin Hydrophobic organization of membrane proteins Are membrane proteins"inside- out"proteins? |
| cord-301827-a7hnuxy5 | The effect of salts on the activity and stability of Escherichia coli and Haloferax volcanii dihydrofolate reductases Halophilic adaptation of protein- DNA interactions Unique amino acid composition of proteins in halophilic bacteria Molecular signature of hypersaline adaptation: insights from genome and proteome composition of halophilic prokaryotes Structural basis for the aminoacid composition of proteins from halophilic archea Electrostatic contributions to the stability of halophilic proteins Viral disorder or disordered viruses: do viral proteins possess unique features? |
| cord-301827-a7hnuxy5 | The importance of being unfolded Heterogeneity of the binding sites of bovine serum albumin Structural studies of p21 Waf1/ Cip1/ Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity What properties characterize the hub proteins of the protein- protein interaction network of Saccharomyces cerevisiae? |
| cord-301827-a7hnuxy5 | The refined crystal structures of the bovine trypsinogen- pancreatic trypsin inhibitor complex and of its ternary complex with Ile- Val at 1.9 A resolution Intrinsic disorder in the Protein Data Bank Protein disorder and the evolution of molecular recognition: theory, predictions and observations Intrinsically unstructured proteins: re- assessing the protein structurefunction paradigm Why are"natively unfolded"proteins unstructured under physiologic conditions? |
| cord-301827-a7hnuxy5 | What does it mean to be natively unfolded? |
| cord-301827-a7hnuxy5 | What's in a name? |
| cord-001835-0s7ok4uw | 3) Can an exhaustive statistical scan of a large, recent dataset identify new side chain interactions at helix termini? |
| cord-001835-0s7ok4uw | A Promoter or Inhibitor for IAPP aggregation? |
| cord-001835-0s7ok4uw | An empirical framework for binary interactome mapping Estimating the size of the human interactome Coming to peace with protein complexes? |
| cord-001835-0s7ok4uw | Are they essential in carrying out a specific cellular function? |
| cord-001835-0s7ok4uw | But the general effects on traits relevant at atomic/ residue resolutions have been less studied, and one fundamental issue remains unsolved: to what extent are proteins forced into interactions with highly concentrated solutes, and with what direct consequences? |
| cord-001835-0s7ok4uw | Can Bio- functionalities be deciphered from protein sequence information using computational approaches? |
| cord-001835-0s7ok4uw | Can site- directed mutagenesis shed light on the refolding pattern of human glucose 6-phosphate dehydrogenase( G6PD)? |
| cord-001835-0s7ok4uw | Can the structure of a protein( H3.1) depend on the treatment of a solvent medium( explicit vs effective) in a coarse- grained computer simulation? |
| cord-001835-0s7ok4uw | Do they play a regulatory role in controlling the on and off of a certain cellular process? |
| cord-001835-0s7ok4uw | How did enzymes, the catalysts of many crucial cellular processes, achieve this cold adaptation? |
| cord-001835-0s7ok4uw | In a protein engineering context, do we need to take into account the dynamics in order to maximize the fitness and function of the resulting proteins? |
| cord-001835-0s7ok4uw | Is there evolutionary pressure to conserve dynamics? |
| cord-001835-0s7ok4uw | Is this necessary to retain functionality, as it has been suggested? |
| cord-001835-0s7ok4uw | Protein engineering: what's next? |
| cord-001835-0s7ok4uw | Questions under- investigation includes what are the effects of mutations( e.g. b- and g- synuclein), how does the structure of an isolated ASN chain change in presence of many interacting protein chains, and how do they organize over the multiple length scales? |
| cord-001835-0s7ok4uw | To what extent are helix- terminal motifs that include multiple amino acids likely to represent genuine cooperative interactions between side chains, rather than chance alignments? |
| cord-001835-0s7ok4uw | Which particular helix- terminal loop geometries are favored by each side chain interaction? |
| cord-266543-ng9zr299 | : are we looking for the appropriate properties? |
| cord-266543-ng9zr299 | Are homology models of G- protein coupled receptors suitable targets? |
| cord-266543-ng9zr299 | Binding affinity: a sufficiently well understood property? |
| cord-266543-ng9zr299 | Does the selected protein exhibit a binding pocket that can be successfully targeted by small molecule ligands? |
| cord-266543-ng9zr299 | How diverse should the entries of a compound database used for screening be? |
| cord-266543-ng9zr299 | How does consensus scoring work for virtual library screening? |
| cord-266543-ng9zr299 | How many leads from HTS? |
| cord-266543-ng9zr299 | How many leads from HTS? |
| cord-266543-ng9zr299 | How well do they cover chemical space, and which portion of this space represents druglike molecules? |
| cord-266543-ng9zr299 | How well is the available chemical space covered? |
| cord-266543-ng9zr299 | However, are such sample pools biased? |
| cord-266543-ng9zr299 | In light of these considerations, what is a suitable compound collection? |
| cord-266543-ng9zr299 | Is it advisable to focus scoring on free energy or would it be better to treat enthalpy and entropy as separate terms in the scoring[ 123]? |
| cord-266543-ng9zr299 | Is there an optimal size for candidate ligands to be submitted to screening? |
| cord-266543-ng9zr299 | Required accuracy of scoring: enrichment or hit identification? |
| cord-266543-ng9zr299 | The disadvantage of this strategy is the fact that additional degrees of scoring are created: what discriminates the scoring against different protein conformers? |
| cord-266543-ng9zr299 | Virtual screening using protein- ligand docking: avoiding artificial enrichment Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings A rule- of- three for fragment- based lead discovery ADMET in silico modelling: towards prediction paradise? |
| cord-266543-ng9zr299 | What is'diverse'in this context? |
| cord-266543-ng9zr299 | What physicochemical properties have to be met by the candidates to guarantee sufficient bioavailability? |
| cord-018133-2otxft31 | Equally important, how are the proteins turned off? |
| cord-018133-2otxft31 | For example, they could provide:( 1) the ability to guess the function of a new protein by assessing its similarity to E. coli genes with a similar sequence,( 2) the ability to ask what the effect on an organism would be if a critical component of a pathway were removed( would other pathways be used to create the desired function, or would the organism lose a vital function and die?), and( 3) the ability to provide a rich user interface to the literature on E. coli metabolism. |
| cord-018133-2otxft31 | GENBANK can be searched efficiently with a number of algorithms and is usually the first stop for a scientist with a new sequence who wonders"Has a sequence like this ever been observed before? |
| cord-018133-2otxft31 | Given two sets of threedimensional coordinates for a set of atoms, what is the best way to superimpose them so that the similarities and differences between the two structures are clear? |
| cord-018133-2otxft31 | How can we analyze the structures of molecules to learn their associated function? |
| cord-018133-2otxft31 | How can we extend the limited structural data by using information in the sequence databases about closely related proteins from different organisms( or within the same organism, but performing a slightly different function)? |
| cord-018133-2otxft31 | How do the proteins function once there? |
| cord-018133-2otxft31 | How does it respond to these medications? |
| cord-018133-2otxft31 | How has the age of genomics changed the landscape of bioinformatics? |
| cord-018133-2otxft31 | How should structures be grouped for the purposes of classification? |
| cord-018133-2otxft31 | If one has, what is known about it? |
| cord-018133-2otxft31 | In addition, the neighbors of a sequence element are also critical, and it is important to be able to perform queries such as,"What sequence elements are seen 20 elements to the left of this element? |
| cord-018133-2otxft31 | It is necessary to support queries such as,"What sequence motifs are present in this sequence? |
| cord-018133-2otxft31 | It provides an excellent introduction to basic molecular biology and biochemistry what ways will bioinformatics and medical informatics interact in the future? |
| cord-018133-2otxft31 | Once genes are transcribed and translated into proteins, into what cellular compartment are the proteins directed? |
| cord-018133-2otxft31 | One of the critical questions facing the genome- sequencing projects is"Can genetic information be misused?" |
| cord-018133-2otxft31 | Should a chapter on bioinformatics appear in a clinical informatics textbook? |
| cord-018133-2otxft31 | Should a patient be informed that he or she is likely to get a disease for which there is no treatment? |
| cord-018133-2otxft31 | The simulation would be a complex mathematical model in which all the molecular details of each organ system would be represented in sufficient detail to allow complex"what if?" |
| cord-018133-2otxft31 | What are two computational challenges in bioinformatics for the future? |
| cord-018133-2otxft31 | What are two problems encountered in analyzing biological sequence, structure, and function? |
| cord-018133-2otxft31 | What is the standard course for this disease? |
| cord-018133-2otxft31 | What more natural user interface could there be for exploring physiology, anatomy, genetics, and biochemistry than the universally recognizable structure of a human that could be browsed at both macroscopic and microscopic levels of detail? |
| cord-018133-2otxft31 | What two changes should we anticipate in the medical record as a result of these new information sources? |
| cord-018133-2otxft31 | When are genes turned on? |
| cord-018133-2otxft31 | Where on the Internet should you look for a DNA sequence, a protein sequence, or a protein structure? |
| cord-018133-2otxft31 | Why have biologists and bioinformaticians embraced the Web as a vehicle for disseminating data so quickly, whereas clinicians and clinical informaticians have been more hesitant to put their primary data online? |
| cord-018133-2otxft31 | Why is sequence, structure, and biological pathway information relevant to medicine? |
| cord-018133-2otxft31 | Why should an awareness of bioinformatics be expected of clinical informatics professionals? |
| cord-018133-2otxft31 | Will the introduction of DNA and protein sequence information change the way that medical records are managed in the future? |
| cord-018133-2otxft31 | Will the same problems arise in basic biomedical research? |
| cord-004584-bcw90f5b | ( Na? dependent)[ 4]. |
| cord-004584-bcw90f5b | / H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | 4000 lmol photons m-2 s-1) have shown that fast component of ms- DF was inhibited faster with time than in case of action of Co 2? and excess light. |
| cord-004584-bcw90f5b | 7, 1518 Budapest, HungaryWide- line proton NMR FID, echoes, spin- lattice and spin- spin relaxation times were measured at 82.55 MHz frequency in the-70 ° C to? |
| cord-004584-bcw90f5b | A putative outer- membrane cytochrome, OmcF, is crucial for Fe 3? |
| cord-004584-bcw90f5b | A recent candidate for pH regulation within early endosomes and TGN is the highly conserved intracellular Na? |
| cord-004584-bcw90f5b | Acyl transfer from lipids without enzyme catalysis: a new paradigm for membrane protein ageing? |
| cord-004584-bcw90f5b | Additional studies have shown that although neither the catalytic reaction nor the establishment of the DpH requires the presence of Na?, the presence of this ion increased the proton transport. |
| cord-004584-bcw90f5b | Analyzing the fluorescence relaxation kinetics,? |
| cord-004584-bcw90f5b | Ca 2? |
| cord-004584-bcw90f5b | Ca 2? and Mn 2?, that can be attributed to their sizes and coordination properties to specific ligands. |
| cord-004584-bcw90f5b | Ca 2? and Mn 2?, that can be attributed to their sizes and coordination properties to specific ligands. |
| cord-004584-bcw90f5b | Ca?? |
| cord-004584-bcw90f5b | Ca?? |
| cord-004584-bcw90f5b | Cell migration or proliferation? |
| cord-004584-bcw90f5b | ClpB is a hexameric AAA? |
| cord-004584-bcw90f5b | Combining all these results, a model for the coupling mechanism of complex I was proposed, suggesting the presence of two different energy coupling sites, one that works only as a proton pump( Na? independent), and the other functioning as a Na? |
| cord-004584-bcw90f5b | Combining all these results, a model for the coupling mechanism of complex I was proposed, suggesting the presence of two different energy coupling sites, one that works only as a proton pump( Na? independent), and the other functioning as a Na? |
| cord-004584-bcw90f5b | Compared to these channels, the voltage- dependence of TRPA1 is very weak( apparent number of gating charges* 0.4 versus 12 in K? channels) and its putative voltage- sensing domain most likely lies outside the S4 because TRPA1 completely lacks positively charged residues in this region. |
| cord-004584-bcw90f5b | Cytoplasmic dynein moves through uncoordinated action of the AAA1 ring domains Ahmet Yildiz Department of Physics, and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 USA Cytoplasmic dynein is a homodimeric AAA? |
| cord-004584-bcw90f5b | During action on chloroplasts only of Cd 2? |
| cord-004584-bcw90f5b | Forward and reverse transport directions were investigated at zero membrane potential using preparations with inside out and right side out oriented transporters with Na? or H? |
| cord-004584-bcw90f5b | Furthermore, Na? |
| cord-004584-bcw90f5b | Generalized epilepsy with febrile seizures plus( GEFS?, OMIM 604233) is a childhood genetic epilepsy syndrome correlated to mutations in the ancillary b- subunit of neuronal voltage- gated sodium channels( NaChs). |
| cord-004584-bcw90f5b | I reduce ubiquinone, it is suggested that the Na?/H? |
| cord-004584-bcw90f5b | I reduce ubiquinone, it is suggested that the Na?/H? |
| cord-004584-bcw90f5b | In addition, our systematic and quantitative analysis( in combination with genetic modifications) provides a tool to study the role of? |
| cord-004584-bcw90f5b | In both strains the pH dependence was associated with a systematic increase of the K m for Na? |
| cord-004584-bcw90f5b | In the photosynthetic reaction center( RC) of Rhodobacter sphaeroides, fast formation of the charge separated state P? |
| cord-004584-bcw90f5b | In the present work, Al 3? induced conformational change and instant oligomerization of aS have been studied using FRET and FCS as main techniques. |
| cord-004584-bcw90f5b | In the shorter(\ 1 ms) time scale, the dominating effect is the re- reduction of the oxidized primary donor( P?? |
| cord-004584-bcw90f5b | In the shorter(\ 1 ms) time scale, the dominating effect is the re- reduction of the oxidized primary donor( P?? |
| cord-004584-bcw90f5b | Initial expression levels were determined by either partial purification using Ni 2?-NTA |
| cord-004584-bcw90f5b | It was observed that the Na? |
| cord-004584-bcw90f5b | It was observed that this bacterial complex I is able of H? |
| cord-004584-bcw90f5b | K? |
| cord-004584-bcw90f5b | Nigericin, a peptide that acts as an H?-K? |
| cord-004584-bcw90f5b | Nigericin, a peptide that acts as an H?-K? |
| cord-004584-bcw90f5b | Result indicates that damage sites of action Cd 2? |
| cord-004584-bcw90f5b | Simultaneous action of Cd 2? and photoinhibitory illumination( |
| cord-004584-bcw90f5b | Taken together with our results on the subcellular localization of the native NHE7, these unique biochemical features provide new insights on the biological function and pathological implications of this intracellular Na? |
| cord-004584-bcw90f5b | The aim of these studies was to clarify whether the specific crystalline structure of protein and protein- substrate interactions are significant for H? |
| cord-004584-bcw90f5b | The available data are restricted and only the re- oxidation of the reduced primary quinone( Q A-? |
| cord-004584-bcw90f5b | The average lifetime of donor in the presence of acceptor increases with the increase of Al 3? |
| cord-004584-bcw90f5b | The coupling ion of the system was shown to be the H? |
| cord-004584-bcw90f5b | The first and best characterized GEFS? |
| cord-004584-bcw90f5b | The intrinsic Tyr fluorescence rises sharply within the mixing dead time, reflecting an enhanced hydrophobicity of the Tyr environment and a fast conformational change of aS. Al 3? |
| cord-004584-bcw90f5b | The simultaneous effect of photoinhibitory illumination and toxic action of heavy metals ions( Cd 2? |
| cord-004584-bcw90f5b | The steadystate level at Cd 2? |
| cord-004584-bcw90f5b | The transmembrane part of the tetrameric TRPA1 is structurally related to the voltagegated K? channels in which the conserved charged residues within the fourth transmembrane region( S4) constitute part of a voltage sensor. |
| cord-004584-bcw90f5b | These data allowed to advance a transport mechanism based on competing Na? |
| cord-004584-bcw90f5b | This inner structure transmits local signals due to ATP binding and hydrolysis by AAA? domains. |
| cord-004584-bcw90f5b | This model was reinforced by further studies performed in the presence of the Na? |
| cord-004584-bcw90f5b | This work was supported by the Italian Association for Cancer Research( AIRC), the Istituto Toscano Tumori and the Associazione Noi per Voi Differential hydration, void volume: which factor provides the main contribution to DV u? |
| cord-004584-bcw90f5b | Thus, notable variations in the RNA binding specificity was observed for the divalent ions of Mg 2? |
| cord-004584-bcw90f5b | Under symmetrical Na? |
| cord-004584-bcw90f5b | Under symmetrical pH conditions with a Na? |
| cord-004584-bcw90f5b | We assume that binding site of Cd 2? is Y Z or CaMn 4-cluster, one of the recombination partners with P 680? |
| cord-004584-bcw90f5b | We assume that binding site of Cd 2? is Y Z or CaMn 4-cluster, one of the recombination partners with P 680? |
| cord-004584-bcw90f5b | We have developed somatic cell genetic techniques that enable the selection of variant cells able to resist H? |
| cord-004584-bcw90f5b | We reported previously that the increase of the cholesterol content of the cell membrane( in vitro) modified the biophysical parameters of the gating of Kvl.3 K? ion channels in human T- lymphocytes. |
| cord-004584-bcw90f5b | What makes an amyloid toxic: morphology, structure or interaction with membranes? |
| cord-004584-bcw90f5b | Whole- cell K? |
| cord-004584-bcw90f5b | and Co 2? are donor and acceptor side of PS2, accordingly. |
| cord-004584-bcw90f5b | and Co 2?) |
| cord-004584-bcw90f5b | and H? |
| cord-004584-bcw90f5b | and Na? |
| cord-004584-bcw90f5b | and U 6? reduction and also for microbial electricity production( 4). |
| cord-004584-bcw90f5b | being transported to the periplasm, contributing in this way to the establishment of the electrochemical potential difference, while Na? is translocated to the cytoplasm[ 4]. |
| cord-004584-bcw90f5b | both alkaline pH and Na? |
| cord-004584-bcw90f5b | by extracellular Ca 2? entry probably through mechanosensitive channels. |
| cord-004584-bcw90f5b | concentration, indicating aS adopts a more extended conformation upon Al 3? |
| cord-004584-bcw90f5b | hERG K? channels is associated with increased risk of arrhythmias. |
| cord-004584-bcw90f5b | killing through plasma membrane expression of H? extruders. |
| cord-004584-bcw90f5b | the fast component of ms- DF, which originates via radiative recombination of reaction center with the CaMn 4-cluster or Y Z on donor side of PS2, is inhibited stronger than at action of only Co 2?. |
| cord-004584-bcw90f5b | treatment is remain stable, while at Co 2? |