trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
in patients with	669
intensive care unit	307
critically ill patients	298
as well as	295
and septic shock	255
the use of	240
the presence of	235
of patients with	223
patients with sepsis	223
sepsis and septic	220
study was to	218
in critically ill	212
the aim of	210
of this study	194
the development of	182
patients with severe	181
is associated with	179
severe sepsis and	168
the incidence of	154
this study was	153
the effect of	151
of severe sepsis	146
with septic shock	146
there was no	145
in the icu	144
the role of	142
with severe sepsis	142
of the patients	141
aim of this	137
the intensive care	134
the number of	133
was associated with	132
the treatment of	132
a total of	131
length of stay	128
to evaluate the	125
the effects of	122
one of the	122
in order to	121
the expression of	120
patients admitted to	118
associated with a	118
in septic shock	118
tumor necrosis factor	117
been shown to	117
in this study	114
multiple organ failure	109
in intensive care	109
admitted to the	109
according to the	100
of the study	100
in septic patients	100
it has been	97
respiratory distress syndrome	96
systemic inflammatory response	96
patients with septic	95
has been shown	94
role in the	94
the severity of	92
due to the	92
in the study	91
in the first	91
of septic shock	89
to assess the	88
acute lung injury	88
to determine the	87
the production of	87
in addition to	86
the risk of	86
apache ii score	86
a number of	85
the impact of	85
were included in	85
there was a	84
was used to	84
to the icu	84
the pathogenesis of	82
the time of	81
the inflammatory response	81
included in the	80
the control group	80
inflammatory response syndrome	80
in response to	80
based on the	78
the most common	78
intensive care units	78
involved in the	78
patients with acute	78
in the treatment	77
patients with a	76
acute kidney injury	76
acute respiratory distress	76
the present study	76
the level of	76
in the presence	74
there is a	74
the end of	73
during the first	73
there were no	72
in both groups	72
of sepsis and	72
to investigate the	72
before and after	70
of mechanical ventilation	70
in the pathogenesis	70
are associated with	69
multiple organ dysfunction	69
morbidity and mortality	69
the study was	68
compared to the	68
the release of	67
patients were included	67
the absence of	65
of sepsis in	64
mean arterial pressure	64
to be a	64
in the intensive	62
risk of death	62
the need for	62
the rate of	61
renal replacement therapy	60
in severe sepsis	60
aim of the	59
associated with the	59
or septic shock	59
at the time	59
significantly higher in	59
was defined as	58
study is to	58
of these patients	57
the first h	57
the management of	57
in terms of	57
an increase in	57
a decrease in	56
surviving sepsis campaign	56
this study is	56
for patients with	56
septic shock patients	56
associated with increased	55
plasma levels of	55
the course of	55
a variety of	55
between the two	55
found to be	55
patients who were	54
the results of	54
the levels of	54
the purpose of	54
at the end	54
with sepsis and	54
in icu patients	53
in the control	53
patients in the	53
has been reported	53
in all patients	53
in patients who	53
the administration of	53
of our study	53
well as the	53
the diagnosis of	53
in these patients	52
sepsis or septic	52
risk factors for	52
the immune system	52
the two groups	52
for the treatment	52
total of patients	52
activation of the	51
levels of il	51
and in the	51
as a result	50
the degree of	50
was significantly higher	50
have shown that	50
related to the	50
treatment of sepsis	50
in the early	50
associated with an	50
was to evaluate	49
of patients were	49
sepsis in the	49
area under the	49
critical care medicine	48
were admitted to	48
as compared with	48
severe sepsis in	48
prospective observational study	47
ill patients with	47
on the other	46
the outcome of	46
mortality in patients	46
shown to be	46
risk factor for	46
activated protein c	46
the emergency department	46
acute renal failure	46
the relationship between	46
as compared to	46
the prevalence of	46
host response to	45
septic shock and	45
in sepsis and	45
of critical care	45
did not differ	45
with or without	45
response to infection	45
the influence of	45
no significant differences	44
septic shock in	44
the patients were	44
we found that	44
been reported to	44
of the inflammatory	44
mechanically ventilated patients	44
acute myocardial infarction	44
of critically ill	44
with respect to	44
the ability of	44
has not been	43
blood samples were	43
within the first	43
depending on the	43
at least one	43
a role in	43
there is no	43
can lead to	43
end of the	42
be used to	42
were used to	42
materials and methods	42
between the groups	42
high levels of	42
in the absence	42
bei patienten mit	41
analysis was performed	41
of icu stay	41
organ failure and	41
the other hand	41
no significant difference	41
is one of	41
the study period	41
the systemic inflammatory	41
severe sepsis or	40
was to investigate	40
the hypothesis that	40
the occurrence of	40
the critically ill	40
with and without	40
the importance of	40
data suggest that	40
of intensive care	40
low birth weight	40
in combination with	40
we investigated the	39
and multiple organ	39
acute respiratory failure	39
understanding of the	39
seems to be	39
studies have shown	39
most of the	39
appears to be	39
we hypothesized that	39
in preterm infants	39
to study the	39
can be used	39
be associated with	39
the duration of	39
of organ dysfunction	38
the onset of	38
was no difference	38
in our study	38
is a common	38
the majority of	38
organ dysfunction syndrome	38
the innate immune	38
to be the	38
may be a	38
a series of	38
changes in the	38
may contribute to	38
was assessed by	38
is an important	38
were associated with	38
were subjected to	37
the risk for	37
significant differences between	37
for more than	37
during the study	37
ligation and puncture	37
an important role	37
management of severe	37
compared with the	37
and mortality in	37
the first hours	37
in the emergency	37
of sepsis is	37
the first days	37
may lead to	37
of the immune	37
admitted to icu	37
in the development	37
for management of	36
the activation of	36
the area under	36
in comparison to	36
important role in	36
cecal ligation and	36
in contrast to	36
was used for	36
part of the	36
were divided into	36
quality of life	36
for severe sepsis	36
was observed in	36
diagnosis of sepsis	36
the efficacy of	36
the pathophysiology of	36
and organ failure	35
nitric oxide synthase	35
of the septic	35
group of patients	35
increase in the	35
the host response	35
a prospective study	35
higher in the	35
infl ammatory response	35
our study was	35
the patients with	35
the amount of	35
we aimed to	35
aim of our	35
and treatment of	35
higher in patients	35
severity of the	34
of nitric oxide	34
cause of death	34
patients were admitted	34
have been shown	34
the immune response	34
in the group	34
traumatic brain injury	34
differences between the	34
a systematic review	34
of the most	34
patients treated with	34
with a mean	33
a reduction in	33
analysis of the	33
of patients admitted	33
contribute to the	33
are needed to	33
admission to the	33
a result of	33
in the blood	33
no difference in	33
was found in	33
in the lung	33
of patients who	33
play a role	33
cm h o	33
at risk of	33
to reduce the	33
to patients with	33
of septic patients	33
organ failure assessment	32
than in the	32
increased risk of	32
innate and adaptive	32
from patients with	32
reactive oxygen species	32
was to assess	32
the association between	32
in critical care	32
effect on the	32
the induction of	32
the most frequent	32
to the development	32
the basis of	32
mortality in the	32
was measured by	32
was no significant	31
patients who died	31
of icu admission	31
was found to	31
production of il	31
at the same	31
were treated with	31
the most important	31
were found to	31
in animal models	31
the formation of	31
in a prospective	31
purpose of this	31
admitted to our	31
difference between the	31
serum levels of	31
in the present	31
the ability to	31
in trauma patients	31
been associated with	31
a period of	31
correlation between the	31
and h after	31
immune response to	31
was to determine	31
were significantly higher	30
into two groups	30
logistic regression analysis	30
of multiple organ	30
in mechanically ventilated	30
of the patient	30
in relation to	30
not associated with	30
mean age of	30
was performed in	30
the combination of	30
for sepsis and	30
was performed using	30
with an increased	30
number of patients	30
disseminated intravascular coagulation	30
a prospective observational	30
and outcome of	30
statistical analysis was	30
was higher in	30
results suggest that	30
by means of	30
the day of	30
in children with	30
the mortality rate	30
we conclude that	30
in case of	29
the same time	29
the united states	29
study was conducted	29
play an important	29
due to a	29
significant difference between	29
the cause of	29
when compared to	29
to compare the	29
mortality rate was	29
we performed a	29
the result of	29
of the host	29
have been reported	29
significant difference in	29
no effect on	29
in vitro and	29
severity of illness	29
response to sepsis	29
it is not	29
of the disease	29
the acute phase	29
on the basis	29
was carried out	29
was the most	29
organ dysfunction in	29
in sepsis patients	29
suggest that the	29
in a murine	29
mean age was	29
the percentage of	29
significant differences in	28
guidelines for management	28
peripheral blood mononuclear	28
lead to a	28
were randomized to	28
a combination of	28
of neonatal sepsis	28
in the united	28
high risk of	28
a model of	28
in the septic	28
sepsis is a	28
divided into two	28
responsible for the	28
duration of mechanical	28
the fact that	28
necrosis factor alpha	28
to play a	28
of adhesion molecules	28
of death in	28
h after the	28
was significantly lower	27
and organ dysfunction	27
differences in the	27
icu length of	27
for the use	27
independently associated with	27
in the liver	27
were observed in	27
is characterized by	27
in the critically	27
blood mononuclear cells	27
icu and hospital	27
to describe the	27
tnf and il	27
followed by a	27
in our icu	27
resulted in a	27
patients suffering from	27
and length of	27
to the intensive	27
in this group	27
very low birth	27
such as the	27
the application of	27
prolonged mechanical ventilation	26
on the day	26
the mean age	26
the context of	26
expression of the	26
difference in the	26
with a high	26
be used as	26
the objective of	26
in the past	26
mechanical ventilation and	26
all the patients	26
the proportion of	26
samples were collected	26
birth weight infants	26
length of icu	26
patients at risk	26
should not be	26
lower in the	26
was to compare	26
definitions for sepsis	26
used in the	26
icu stay and	26
has been demonstrated	26
increased risk for	26
in patients undergoing	26
used as a	26
likely to be	26
admitted to a	26
of patients had	26
of stay in	26
are involved in	26
sequential organ failure	26
results indicate that	26
evaluation of the	25
the beginning of	25
adult patients with	25
patients were divided	25
in neonates with	25
no differences in	25
management of sepsis	25
surgical intensive care	25
are known to	25
an increased risk	25
have not been	25
apache ii and	25
of the blood	25
the activity of	25
arterial blood pressure	25
with regard to	25
we conducted a	25
each of the	25
septic shock is	25
be due to	25
a dose of	25
the increase in	25
all patients were	25
to determine whether	25
be involved in	25
the incidence and	25
were obtained from	25
and safety of	25
observed in the	25
patients who underwent	25
appear to be	25
these data suggest	25
in peripheral blood	25
increase the risk	24
who were admitted	24
who did not	24
innate immune response	24
none of the	24
the icu and	24
all patients admitted	24
has also been	24
the complement system	24
the apache ii	24
factors associated with	24
to identify the	24
for the first	24
are shown in	24
were enrolled in	24
data were collected	24
is the most	24
should be considered	24
in the pathophysiology	24
expression of cd	24
significantly lower in	24
a significant increase	24
associated with higher	24
herpes simplex virus	24
detect sepsis sensor	24
considered to be	24
after cardiac surgery	24
were compared with	24
derived from the	24
neonates with sepsis	24
intensive care patients	24
the animals were	24
the type of	24
under the curve	24
with a median	24
aim was to	24
adaptive immune system	23
compared to control	23
with a higher	23
was induced by	23
a murine model	23
in this model	23
and intensive care	23
significant increase in	23
the response to	23
were found in	23
more likely to	23
at risk for	23
in neonatal sepsis	23
this is a	23
sepsis and organ	23
and duration of	23
were no significant	23
sepsis septic shock	23
may not be	23
could not be	23
of organ failure	23
cd and cd	23
innate immune system	23
cd t cells	23
and after the	23
is involved in	23
international guidelines for	23
the surviving sepsis	23
with acute respiratory	23
the lack of	23
further studies are	23
may play a	23
organ dysfunction and	23
endothelial cells and	23
development of sepsis	23
the implementation of	23
were measured by	23
of hospital stay	23
of the present	23
icu patients with	23
patients who had	23
during icu stay	23
a patient with	23
in patients receiving	23
the value of	23
of the following	23
in of patients	23
of reactive oxygen	22
of acute kidney	22
inflammatory response to	22
are able to	22
intensive care and	22
hospital mortality was	22
outcome in patients	22
at icu admission	22
for at least	22
guidelines for the	22
receiver operating characteristic	22
from january to	22
the function of	22
to have a	22
mortality rate of	22
and is associated	22
was seen in	22
after icu admission	22
dependence risk score	22
patients with and	22
associated with high	22
role of the	22
study of patients	22
shown in table	22
the length of	22
defined as the	22
the prevention of	22
transforming growth factor	22
of the innate	22
increased expression of	22
of the complement	22
in the plasma	22
ventilator dependence risk	22
host immune response	22
and severity of	22
increased in the	22
with increased mortality	22
be related to	22
in the context	22
in critical illness	22
patients had a	22
associated with sepsis	22
present study was	22
the addition of	22
we examined the	22
a lack of	22
the cell surface	22
and sofa score	22
the site of	22
hospital length of	22
was found between	22
were measured in	22
intensive care medicine	22
was a significant	21
of critical illness	21
the mechanism of	21
regulation of the	21
in the same	21
significantly higher than	21
needs to be	21
cells in the	21
the concentration of	21
found in the	21
and hospital mortality	21
murine model of	21
may result in	21
in patients admitted	21
defined as a	21
and hours after	21
medical intensive care	21
randomized controlled trial	21
vitro and in	21
is known about	21
compared to patients	21
the changes in	21
patients admitted in	21
retrospective cohort study	21
of infection in	21
objective of this	21
in the number	21
patients who developed	21
was performed to	21
patients with sirs	21
did not change	21
hospital cardiac arrest	21
treatment of severe	21
inflammatory response in	21
independent risk factor	21
extracorporeal membrane oxygenation	21
patients with suspected	21
in a large	21
reported to be	21
stages of sepsis	21
the coagulation cascade	21
the introduction of	21
is related to	21
in the literature	21
was determined by	21
is the first	21
in preterm neonates	21
the setting of	21
presence of a	21
human endothelial cells	21
at a dose	21
and outcome in	21
to be more	21
in all groups	21
invasive mechanical ventilation	20
in a model	20
in very low	20
admitted in the	20
mean apache ii	20
to examine the	20
stay in icu	20
central venous pressure	20
had no effect	20
ii score was	20
outcome of patients	20
systemic vascular resistance	20
the adaptive immune	20
this study we	20
of all patients	20
contributes to the	20
the epidemiology of	20
of mg kg	20
the extent of	20
in neutropenic patients	20
thought to be	20
after icu discharge	20
not differ between	20
the first time	20
as part of	20
we evaluated the	20
test was used	20
of inflammatory cytokines	20
the measurement of	20
admission to icu	20
the start of	20
than that of	20
and adaptive immune	20
levels were measured	20
acute phase proteins	20
a and b	20
compared to those	20
for each patient	20
more than h	20
seem to be	20
was defined by	20
a diagnosis of	20
of endothelial cells	20
to intensive care	20
adult respiratory distress	20
and severe sepsis	20
these results suggest	20
is a major	20
of the coagulation	20
known to be	20
among patients with	20
of icu patients	20
of tumor necrosis	20
an independent risk	20
this may be	20
of gene expression	19
this is the	19
hours after the	19
mortality and morbidity	19
plasma concentrations of	19
data indicate that	19
lower in patients	19
little is known	19
samples were taken	19
of the clinical	19
tlr and tlr	19
has been associated	19
ability of the	19
of antibiotic therapy	19
correlated with the	19
of infection and	19
the distribution of	19
components of the	19
higher risk of	19
primary outcome was	19
we found a	19
on admission day	19
review of the	19
because of the	19
be responsible for	19
no difference between	19
and should be	19
higher than the	19
sensitivity and specificity	19
animal models of	19
in of cases	19
is defined as	19
proportion of patients	19
red blood cells	19
central nervous system	19
of systemic inflammation	19
we studied the	19
in the second	19
in a mouse	19
course of the	19
ii and sofa	19
a marker of	19
there are no	19
survival in patients	19
in the patients	19
during septic shock	19
in accordance with	19
study of the	19
safety and efficacy	19
could be used	19
the quality of	19
mouse model of	19
the regulation of	19
of our patients	19
within hours of	19
model of sepsis	19
in human sepsis	19
in comparison with	19
is not a	19
a group of	19
in clinical practice	19
of patients in	19
were no differences	19
organ failure in	19
were able to	19
sepsis and multiple	19
the detection of	19
the frequency of	19
the goal of	19
the primary outcome	19
prospective cohort study	19
in a rat	19
to improve the	19
an attempt to	18
which may be	18
our understanding of	18
patients with multiple	18
the first day	18
it was found	18
age of years	18
systematic review and	18
is known to	18
to be associated	18
in vitro studies	18
associated with mortality	18
were significantly lower	18
levels in the	18
between patients with	18
in the management	18
has been used	18
between january and	18
study was performed	18
and in vivo	18
time course of	18
is to evaluate	18
major cause of	18
patients with the	18
survivors and non	18
a subset of	18
was designed to	18
was present in	18
data was collected	18
with the development	18
a significant difference	18
regulatory t cells	18
the patients who	18
ischemia reperfusion injury	18
a major role	18
th and th	18
has been proposed	18
shown that the	18
the sofa score	18
at baseline and	18
development of the	18
severity of sepsis	18
levels of tnf	18
the normal range	18
and chronic health	18
patients with chronic	18
and apache ii	18
a retrospective analysis	18
to test the	18
associated with severe	18
to investigate whether	18
leading cause of	18
was conducted in	18
levels were significantly	18
was obtained from	18
were compared using	18
to define the	18
half of the	18
of intravenous immunoglobulin	18
many of the	18
septic shock was	18
groups of patients	18
arterial blood gas	18
we compared the	18
was induced in	18
need to be	18
is based on	18
in the hospital	18
to hospital discharge	18
the accuracy of	18
is thought to	18
for the development	18
in the inflammatory	18
cardiac output and	18
seen in the	18
epidemiology of sepsis	18
increased levels of	18
and the presence	18
to analyze the	18
is able to	18
were collected from	18
not significantly different	18
studies are needed	18
it may be	18
die gabe von	18
septic patients and	18
patients with an	17
coronary artery bypass	17
is due to	17
and efficacy of	17
medical and surgical	17
use of a	17
was lower in	17
defined by the	17
efficacy and safety	17
a review of	17
participate in the	17
was not associated	17
a university hospital	17
the evaluation of	17
is mediated by	17
the magnitude of	17
any of the	17
it can be	17
a mean age	17
in some patients	17
level of consciousness	17
are likely to	17
that of the	17
in the immune	17
tumour necrosis factor	17
onset of sepsis	17
more than hours	17
we observed a	17
have been identified	17
all patients with	17
chronic health evaluation	17
the association of	17
the septic syndromes	17
of recombinant human	17
systemic infl ammatory	17
and patients with	17
the innate and	17
been reported that	17
a wide range	17
in the clinical	17
patients were enrolled	17
and management of	17
protective effect of	17
approved by the	17
and at the	17
in a dose	17
significantly associated with	17
cells of the	17
of at least	17
source of infection	17
was evaluated by	17
have also been	17
well as a	17
may also be	17
effect of a	17
in the lungs	17
we did not	17
a mouse model	17
for treatment of	17
be a useful	17
at the icu	17
were admitted in	17
course of sepsis	17
one or more	17
median age of	17
patients did not	17
was higher than	17
study was designed	17
results of the	17
for the management	17
major role in	17
white blood cell	17
plasminogen activator inhibitor	17
in the acute	17
during the course	17
risk of developing	17
ng ml in	17
a rat model	17
for septic shock	17
a risk factor	17
mortality rates were	17
to severe sepsis	17
differences between groups	17
predictive value of	16
was significantly reduced	16
intercellular adhesion molecule	16
and on the	16
higher levels of	16
site of infection	16
is essential for	16
analysis showed that	16
observed in patients	16
will be discussed	16
in the setting	16
ml kg h	16
the initiation of	16
therapy in the	16
higher than in	16
dose of mg	16
compared to controls	16
a retrospective study	16
prognostic value of	16
within h of	16
been implicated in	16
coronary artery disease	16
in the serum	16
of the cases	16
red blood cell	16
first h after	16
in der sepsis	16
the receiver operating	16
years of age	16
an increase of	16
in association with	16
wide range of	16
in patients treated	16
the action of	16
study conducted in	16
two or more	16
have been used	16
conducted a prospective	16
it is a	16
onset sepsis in	16
has been suggested	16
the third international	16
acute physiology score	16
ventilator dependence in	16
under the roc	16
activity of the	16
a positive correlation	16
are presented as	16
between survivors and	16
may be the	16
is needed to	16
randomized to receive	16
of inflammation and	16
in the host	16
in the sepsis	16
results of a	16
which is a	16
from mechanical ventilation	16
the safety and	16
and min after	16
whitney u test	16
clinical and laboratory	16
apache ii scores	16
results show that	16
of patients was	16
organ system failure	16
of less than	16
in of the	16
cytokines such as	16
written informed consent	16
of the human	16
in the uk	16
was found that	16
and nitric oxide	16
epidemiology of severe	16
intravenous immunoglobulin for	16
in all the	16
treatment of septic	16
present in the	16
a key role	16
the icu with	16
critically ill patient	16
it should be	16
major abdominal surgery	16
but not in	16
in two groups	16
may be useful	16
mortality in septic	16
that there is	16
in an attempt	16
physiology and chronic	16
are capable of	16
from septic shock	16
remains to be	16
death in the	16
associated molecular patterns	16
improves survival in	16
there is an	16
in elderly patients	16
patients were excluded	16
septic and non	16
blood pressure and	16
patients with or	16
an intensive care	16
are expressed as	16
and of the	16
obtained from the	16
prior to the	16
we studied patients	16
severe acute respiratory	16
patients with infection	16
arterial and venous	16
central venous catheter	16
c h hej	16
white blood cells	15
used to identify	15
sepsis has been	15
had at least	15
with high mortality	15
male wistar rats	15
samples were obtained	15
response to lps	15
patients with ards	15
and dendritic cells	15
correlation was found	15
used to assess	15
this study were	15
which has been	15
significantly decreased in	15
were not significantly	15
that it is	15
to septic shock	15
evaluate the effect	15
in group a	15
during the last	15
length of hospital	15
to estimate the	15
rat model of	15
in sepsis is	15
was used in	15
there is also	15
of sepsis on	15
over a period	15
the icu stay	15
the nature of	15
to critical care	15
risk factors and	15
inflammatory response and	15
of the experiment	15
in patients without	15
a control group	15
patients who received	15
the host immune	15
significant decrease in	15
and outcomes of	15
period of time	15
our aim was	15
led to a	15
the correlation between	15
of the sepsis	15
in the groups	15
on the first	15
it is possible	15
enrolled in the	15
systolic blood pressure	15
to our knowledge	15
the timing of	15
immune response and	15
is responsible for	15
such as il	15
and mechanical ventilation	15
high doses of	15
are the most	15
and regulation of	15
and critical care	15
of the lung	15
mortality in sepsis	15
induced lung injury	15
patients who are	15
did not show	15
these patients were	15
the increase of	15
the generation of	15
study showed that	15
the time course	15
low levels of	15
recent studies have	15
to increase the	15
a comparison of	15
stay in the	15
experimental and clinical	15
acute physiology and	15
a randomized controlled	15
of cytokines and	15
of stay and	15
of acute lung	15
and with the	15
from severe sepsis	15
of the adaptive	15
male and female	15
intensive insulin therapy	15
mean arterial blood	15
found that the	15
to the control	15
in our hospital	15
patients presenting with	15
out of patients	15
in the course	15
septic shock with	15
response to a	15
review and meta	15
department of surgery	15
a systemic inflammatory	15
risk of mortality	15
significant reduction in	15
inhibition of the	15
significantly increased in	15
the decision to	15
were performed in	15
levels in patients	15
at admission and	15
impact on the	15
the decrease of	15
in those with	15
tissue factor pathway	15
of mortality in	15
on the contrary	15
which can be	15
this retrospective study	15
a significant correlation	15
development of a	15
reports suggest that	15
large number of	15
be useful in	15
signs and symptoms	15
in endothelial cells	15
its impact on	15
mobility group box	15
in the circulation	15
from septic patients	15
rats subjected to	15
performed a retrospective	15
the roc curve	15
the analysis of	15
and the other	15
had a higher	15
ml kg of	15
animals were sacrificed	15
of protein c	15
the synthesis of	15
was calculated as	15
response to the	15
the risk factors	15
some of the	15
were isolated from	15
in acute lung	15
with sepsis syndrome	15
the design of	15
for critically ill	15
decrease in the	15
the reduction of	15
the concept of	15
was able to	15
during sepsis and	15
at the bedside	15
and may be	15
to the study	15
in the neonatal	15
no correlation between	15
in adult patients	15
within h after	14
to be of	14
from the blood	14
all adult patients	14
not appear to	14
associated with poor	14
spontaneous breathing trial	14
and of patients	14
the sepsis timeline	14
and had a	14
of the total	14
and the use	14
third international consensus	14
is present in	14
ill patients is	14
ammatory response syndrome	14
effects on the	14
may have a	14
and development of	14
acute liver failure	14
werdan et al	14
l min m	14
was performed by	14
may be related	14
the inflammatory process	14
a consequence of	14
different types of	14
is likely to	14
not statistically significant	14
inducible nitric oxide	14
in the kidney	14
factor pathway inhibitor	14
patients compared to	14
implementation of a	14
as a marker	14
with sepsis or	14
in this setting	14
day mortality in	14
the clinical course	14
pg ml and	14
ml in the	14
and type of	14
in the production	14
objectives of the	14
of neutropenic fever	14
relationship between the	14
due to an	14
in those patients	14
did not affect	14
hospital mortality in	14
a sensitivity of	14
as a consequence	14
measured by the	14
effect of the	14
mechanical ventilation in	14
the emergency room	14
most common cause	14
injury severity score	14
purpose of the	14
the effectiveness of	14
indicate that the	14
are thought to	14
cause of mortality	14
characteristics of the	14
icu mortality was	14
patients were followed	14
and the number	14
this was a	14
levels of the	14
these results indicate	14
we wanted to	14
the potential to	14
risk for sepsis	14
pediatric septic shock	14
lung injury and	14
many of these	14
innate immune responses	14
and endothelial cells	14
common cause of	14
level of the	14
a higher risk	14
multivariate logistic regression	14
of peripheral blood	14
key role in	14
pg ml in	14
were higher in	14
of acute illness	14
the overall mortality	14
as shown in	14
used to determine	14
fi ndet sich	14
found in patients	14
carried out in	14
data were analyzed	14
the care of	14
doses of hydrocortisone	14
included in this	14
addition to the	14
at high risk	14
were determined by	14
and has been	14
the inhibition of	14
higher incidence of	14
in der regel	14
is the main	14
cohort of patients	14
by flow cytometry	14
was not statistically	14
is supported by	14
groups according to	14
consecutive patients with	14
of proinflammatory cytokines	14
pathophysiology of sepsis	14
on the cell	14
to predict the	14
the in vitro	14
were used for	14
was based on	14
under the receiver	14
human immunodeficiency virus	14
in this retrospective	14
survival in a	14
in vivo and	14
reduction in the	14
first hours of	14
such as tnf	14
high concentrations of	14
patients were studied	14
observational study of	14
discharge from the	14
the possibility of	14
and the incidence	14
the involvement of	14
first days of	14
the identification of	14
assessment of the	14
age was years	14
human septic shock	14
is believed to	14
well as in	14
human leukocyte antigen	14
expressed as mean	14
of all the	14
risk factors of	14
total number of	14
children with septic	14
to our icu	14
the source of	13
the patients in	13
for all patients	13
admitted in icu	13
and inhibition of	13
care and emergency	13
all of them	13
was shown to	13
has been implicated	13
of the cell	13
be considered in	13
more than of	13
two groups of	13
a reduction of	13
of inflammatory mediators	13
consensus definitions for	13
human umbilical vein	13
of neutrophils in	13
not differ significantly	13
seen in patients	13
clinical signs of	13
were compared to	13
of the major	13
have to be	13
arterial blood gases	13
a high mortality	13
of the two	13
more than one	13
showed a significant	13
society of critical	13
neonatal sepsis and	13
a state of	13
and mechanically ventilated	13
the study of	13
severity of disease	13
will be presented	13
incidence and mortality	13
were detected in	13
change in the	13
at the beginning	13
included patients with	13
in group b	13
this group of	13
international consensus definitions	13
there has been	13
probably due to	13
of them were	13
of escherichia coli	13
and release of	13
to the medical	13
in whole blood	13
cytokine production in	13
trained immunity in	13
as measured by	13
been used in	13
at the onset	13
von willebrand factor	13
quality of care	13
the patients had	13
was measured using	13
believed to be	13
the determination of	13
were exposed to	13
a prospective cohort	13
at and h	13
on the surface	13
from the hospital	13
moderate to severe	13
in experimental sepsis	13
retrospective observational study	13
was recorded in	13
development of multiple	13
and mortality of	13
first day of	13
phase of sepsis	13
to sepsis and	13
the surface of	13
been shown that	13
heart rate and	13
animal model of	13
the first week	13
and did not	13
sepsis in a	13
on admission and	13
study aimed to	13
been found to	13
that can be	13
in the last	13
were analyzed by	13
lead to the	13
statistically significant difference	13
characterized by a	13
of innate immunity	13
between two groups	13
the decrease in	13
cohort study of	13
did not have	13
diagnosis and treatment	13
patients with high	13
preterm and term	13
a statistically significant	13
severe sepsis is	13
cytokine production and	13
septic shock are	13
dysfunction in sepsis	13
was used as	13
production of tnf	13
colony stimulating factor	13
can also be	13
from the gut	13
in icu was	13
have been described	13
we tested the	13
and the occurrence	13
microvascular endothelial cells	13
for statistical analysis	13
incidence of delirium	13
in this population	13
in the initial	13
plasma concentration of	13
with an increase	13
there was an	13
in a significant	13
subset of patients	13
these data indicate	13
is considered to	13
was approved by	13
to h after	13
of the first	13
was no correlation	13
and to evaluate	13
t cells and	13
the prowess trial	13
to the emergency	13
showed that the	13
consistent with the	13
was performed on	13
the group of	13
the benefits of	13
up to days	13
during and after	13
is important to	13
there have been	13
to endothelial cells	13
this study aimed	13
during their icu	13
that there was	13
members of the	13
after cardiac arrest	13
low cardiac output	13
of the systemic	13
at least in	13
an association between	13
for each of	13
a central role	13
leads to a	13
especially in the	13
in the future	13
failure and death	13
it is also	13
objective was to	13
has been studied	13
after the operation	13
in a variety	13
differences were found	13
it is important	13
according to a	13
was related to	13
the detect sepsis	13
of trained immunity	13
in the following	13
the total number	13
and central venous	13
the placebo group	13
and heart rate	13
of a new	13
our study is	13
studies suggest that	13
the process of	13
a significant decrease	13
the capacity of	13
bone marrow transplantation	13
of tnf and	13
american college of	13
from healthy volunteers	13
sepsis is the	13
and activation of	13
is produced by	13
its effect on	13
over the last	13
pathogenesis of sepsis	13
a median of	13
during mechanical ventilation	13
tnfa and il	13
data are presented	13
was no statistical	12
early diagnosis of	12
in the placebo	12
polymerase chain reaction	12
mean age years	12
cells in vitro	12
out of the	12
simplified acute physiology	12
in human septic	12
a common complication	12
their icu stay	12
decreased in the	12
to multiple organ	12
show that the	12
in a number	12
in conjunction with	12
risk for infection	12
administration of ivig	12
the current study	12
the binding of	12
result of the	12
for the prevention	12
not able to	12
the dose of	12
vascular smooth muscle	12
therapies in sepsis	12
to respond to	12
preterm infants with	12
in the prowess	12
systemic inflammation and	12
early phase of	12
these reports suggest	12
patients were classified	12
analysis of a	12
similar to the	12
increased susceptibility to	12
im septischen schock	12
ideal body weight	12
the response of	12
to explore the	12
in the patient	12
the difference between	12
been studied in	12
reduction in mortality	12
a month period	12
patients with aki	12
the reasons for	12
was supported by	12
was increased in	12
high incidence of	12
which in turn	12
and the subsequent	12
during the period	12
no statistically significant	12
a significantly higher	12
were obtained at	12
h prior to	12
group b streptococcal	12
the evolution of	12
nature of the	12
of the procedure	12
on endothelial cells	12
a significant reduction	12
in spite of	12
the early phase	12
at icu discharge	12
of acute respiratory	12
in surgical patients	12
depends on the	12
to clarify the	12
in the adult	12
of ml kg	12
increases the risk	12
of the drug	12
the results showed	12
known about the	12
in healthy volunteers	12
shock and sepsis	12
were shown to	12
on mortality in	12
study in a	12
increased mortality in	12
group compared to	12
health evaluation ii	12
did not receive	12
mortality rate in	12
expressed on the	12
immune response in	12
to be an	12
or more of	12
retrospective analysis of	12
in a university	12
at h and	12
and symptoms of	12
the septic response	12
septic patients with	12
the appearance of	12
day mortality was	12
and sofa scores	12
mechanism of action	12
was measured in	12
im vergleich zu	12
of inspired oxygen	12
the septic shock	12
presented as median	12
data on the	12
lower respiratory tract	12
and in patients	12
the potential for	12
are required to	12
at h after	12
therapy in sepsis	12
were determined in	12
in patients in	12
of these two	12
and tumor necrosis	12
prospective study was	12
leading to the	12
followed by the	12
this suggests that	12
occurred in patients	12
decrease of the	12
an indicator of	12
the loss of	12
icu stay was	12
from april to	12
can be detected	12
management of patients	12
poor outcome in	12
used as an	12
were measured at	12
after the first	12
to ng ml	12
play a major	12
to those of	12
than in those	12
factors such as	12
in the regulation	12
fraction of inspired	12
with the severity	12
of stay was	12
a time to	12
fl uid resuscitation	12
used for the	12
observational study was	12
the kinetics of	12
led to the	12
the development and	12
and can be	12
status of the	12
with mortality in	12
similar to those	12
sepsis in very	12
rats treated with	12
body mass index	12
the patient was	12
is a useful	12
in the systemic	12
an incidence of	12
found to have	12
on admission to	12
we have previously	12
to activation of	12
acute respiratory syndrome	12
caused by the	12
to determine if	12
age of the	12
the study included	12
and prognosis of	12
neutropenic patients with	12
icu of a	12
patients undergoing cardiac	12
or in the	12
implicated in the	12
may be an	12
could be a	12
to receive either	12
referred to as	12
sofa score was	12
the characteristics of	12
those patients who	12
an average of	12
of circular rnas	12
vascular endothelial cells	12
majority of patients	12
mg kg day	12
mortality of patients	12
the host defense	12
results in the	12
clinical trials of	12
was significantly decreased	12
results from the	12
a decrease of	12
the mortality of	12
increased vascular permeability	12
and with a	12
we included patients	12
from the first	12
smooth muscle cells	12
to be involved	12
severity of acute	12
associated with decreased	12
sepsis and the	12
a history of	12
were the most	12
a median age	12
negative predictive value	12
should be used	12
endothelial cell adhesion	12
of the respiratory	12
and mortality rates	12
to decrease the	12
the acute respiratory	12
a large number	12
detected in the	12
study aims to	12
demonstrated that the	12
the likelihood of	12
collected data from	11
is a potent	11
undergoing cardiac surgery	11
glasgow coma scale	11
is followed by	11
or in combination	11
animals treated with	11
as a potential	11
in the us	11
was to study	11
body surface area	11
during the icu	11
blood was collected	11
over a month	11
we have recently	11
expression of mir	11
presence or absence	11
is induced by	11
infections in the	11
as a diagnostic	11
were studied in	11
to the increased	11
early and late	11
a higher mortality	11
has to be	11
the form of	11
the tidal volume	11
defined according to	11
of the infection	11
response of the	11
icu were included	11
umbilical vein endothelial	11
previous studies have	11
to explain the	11
h and h	11
by using the	11
may be due	11
or absence of	11
recorded in the	11
of cases of	11
critically ill adults	11
models of sepsis	11
an observational study	11
more than days	11
respect to the	11
also associated with	11
activator inhibitor type	11
patients who did	11
with increased risk	11
by the presence	11
with the use	11
within the normal	11
and could be	11
elevated levels of	11
between groups were	11
icu admission and	11
in patients after	11
with suspected sepsis	11
production of cytokines	11
better understanding of	11
was collected from	11
liver and spleen	11
to identify patients	11
inflammatory and anti	11
were analyzed with	11
in the postoperative	11
was similar in	11
neutrophil extracellular traps	11
intravenous immune globulin	11
for renal replacement	11
inflammatory response is	11
investigate the effect	11
severe sepsis was	11
mean values of	11
and acute respiratory	11
which is associated	11
that have been	11
one of these	11
mesenteric lymph nodes	11
at least two	11
bacterial infections in	11
of bone marrow	11
outcome in sepsis	11
widely used in	11
after the onset	11
s p levels	11
was administered to	11
can result in	11
of a number	11
hours after surgery	11
cell adhesion molecule	11
the plasma of	11
the intensity of	11
intravenous injection of	11
low doses of	11
patienten mit kardiogenem	11
a tidal volume	11
in gene expression	11
a high risk	11
in the right	11
early stage of	11
circulating levels of	11
are responsible for	11
soluble tnf receptors	11
t cells are	11
on day after	11
h after clp	11
of the lps	11
and the mean	11
investigate the effects	11
compared to a	11
sepsis and its	11
was detected in	11
but it is	11
the icu setting	11
was an independent	11
on intensive care	11
was performed with	11
of more than	11
with sepsis are	11
the interaction of	11
of tissue factor	11
on mechanical ventilation	11
a mean arterial	11
in early sepsis	11
may be associated	11
were lower in	11
up to of	11
study were to	11
of the cytokine	11
for up to	11
than the control	11
the prognosis of	11
sepsis was induced	11
the contact system	11
median age was	11
that patients with	11
patients have been	11
on the clinical	11
the recognition of	11
low tidal volume	11
alterations in the	11
of the current	11
a clinical trial	11
the volume of	11
we used a	11
severe traumatic brain	11
apoptotic cell death	11
correlated well with	11
sepsis can be	11
have been proposed	11
weaning from mechanical	11
ill patients in	11
ventilator associated pneumonia	11
blood levels of	11
were defined as	11
the range of	11
has been observed	11
requiring mechanical ventilation	11
were performed at	11
first h of	11
all of the	11
there are a	11
the feasibility of	11
and emergency medicine	11
the contribution of	11
in icu and	11
artery bypass grafting	11
on the same	11
patients and methods	11
plasmacytoid dendritic cells	11
not statistically different	11
cytokines and chemokines	11
were carried out	11
may serve as	11
of lps and	11
and sepsis in	11
gene expression in	11
was not significantly	11
soluble tnf receptor	11
adaptive immune response	11
at t and	11
up to h	11
were used as	11
of the literature	11
and was associated	11
complicating acute myocardial	11
excluded from the	11
a major cause	11
risk factors associated	11
c bl mice	11
be caused by	11
causes of death	11
we assessed the	11
to that of	11
in a recent	11
of a novel	11
the postoperative period	11
levels were found	11
sepsis is an	11
patients in whom	11
is well known	11
were more likely	11
we used the	11
in each group	11
of the icu	11
of delirium in	11
were collected at	11
in an experimental	11
been demonstrated to	11
randomly assigned to	11
human activated protein	11
according to their	11
to a significant	11
the endothelial cell	11
survival in sepsis	11
not be used	11
no differences were	11
value of the	11
were incubated with	11
assessed by the	11
after intensive care	11
infants with sepsis	11
survival of patients	11
in the other	11
the ventilator dependence	11
the sepsis syndrome	11
is necessary to	11
use in the	11
patients from the	11
men and women	11
and the severity	11
be one of	11
partial pressure of	11
findings suggest that	11
a cohort of	11
of drotrecogin alfa	11
the peripheral blood	11
phage therapy in	11
the medical icu	11
a critical role	11
were classified as	11
not show any	11
pao fio ratio	11
effects of these	11
with more than	11
outcome of the	11
the most severe	11
treatment of patients	11
significantly reduced in	11
and cytokine production	11
was considered significant	11
day of icu	11
t cells in	11
the multiple organ	11
to contribute to	11
neonatal sepsis in	11
of morbidity and	11
were divided in	11
were compared between	11
mortality rates in	11
recombinant human activated	11
increased incidence of	11
with multiple organ	11
the fi rst	11
superior vena cava	11
all patients had	11
brain injury and	11
in out of	11
in the analysis	11
served as controls	11
and function of	11
in any of	11
all patients who	11
increase in serum	11
data from patients	10
only in the	10
heat shock proteins	10
of healthy volunteers	10
we sought to	10
serve as a	10
of neutrophils to	10
renal failure in	10
contributing to the	10
be used for	10
is not known	10
in the rat	10
and the host	10
it is well	10
septic shock were	10
is dependent on	10
positive blood cultures	10
the assessment of	10
the utility of	10
in newborn infants	10
acute brain dysfunction	10
of whole blood	10
control of the	10
the statistical analysis	10
a role for	10
of renal function	10
compared to healthy	10
a pilot study	10
our intensive care	10
the validity of	10
to the lung	10
central role in	10
in the incidence	10
confusion assessment method	10
immune status of	10
all patients received	10
significantly correlated with	10
clinical trial of	10
for development of	10
of odontogenic infections	10
the difference in	10
adult patients admitted	10
in a series	10
the size of	10
be found in	10
protein c for	10
and it is	10
in clinical trials	10
h in the	10
a recent study	10
production of the	10
the median time	10
in surgical intensive	10
patients were randomized	10
pivotal role in	10
early stages of	10
the university of	10
in burn patients	10
as a prognostic	10
the face of	10
lung injury in	10
the potential of	10
in line with	10
of infectious diseases	10
severe septic patients	10
septic shock the	10
in vitro experiments	10
the polarization of	10
the piro system	10
stage of sepsis	10
those patients with	10
in the case	10
mit kardiogenem schock	10
the definition of	10
of the critically	10
release of the	10
with the control	10
may be involved	10
their ability to	10
least in part	10
as defined by	10
have reported that	10
patients were treated	10
defined by a	10
association between the	10
results from a	10
results showed that	10
early identification of	10
was lower than	10
to the severity	10
total body surface	10
in which the	10
the results were	10
associated with significant	10
differ significantly between	10
the clearance of	10
been observed in	10
patienten mit sepsis	10
activation of nf	10
use of innovative	10
and increased mortality	10
the inflammatory reaction	10
is required to	10
days of icu	10
the values of	10
serum samples were	10
were recorded in	10
whether or not	10
compared to non	10
prospective study of	10
early administration of	10
the basis for	10
in the elderly	10
implementation of the	10
and to a	10
the resolution of	10
is difficult to	10
with at least	10
has been a	10
start of the	10
to pg ml	10
the field of	10
the necessity of	10
should be avoided	10
venous oxygen saturation	10
in sepsis the	10
mhc class ii	10
of infl ammation	10
of innovative therapies	10
is a risk	10
lung injury was	10
patients with hematological	10
tidal volume of	10
logistic regression model	10
was measured as	10
contributed to the	10
which leads to	10
were used in	10
intensity of the	10
because it is	10
outcomes of patients	10
was determined using	10
and the risk	10
in cardiac output	10
the progression of	10
been identified as	10
evidence for the	10
sepsis study group	10
t and t	10
and the acute	10
with a decrease	10
of the severity	10
serum amyloid a	10
on the icu	10
that could be	10
patients with respiratory	10
compared to normal	10
group and in	10
for the study	10
and guidelines for	10
in pediatric sepsis	10
higher rate of	10
of central venous	10
beneficial effects of	10
of th cells	10
the outcomes of	10
with an average	10
significant improvement in	10
both groups of	10
the period of	10
in the mortality	10
of clinical trials	10
and cd b	10
continuous renal replacement	10
in recent years	10
level in the	10
risk score was	10
patients with community	10
efficacy of the	10
for prevention of	10
in cardiac surgery	10
after adjustment for	10
was followed by	10
hospital mortality rate	10
january to december	10
of sepsis patients	10
operating characteristic curve	10
significant difference was	10
significant correlation between	10
that leads to	10
is a frequent	10
two groups were	10
can be found	10
has been described	10
by cecal ligation	10
of aki in	10
in preterm and	10
to protect the	10
for sepsis in	10
the th day	10
cardiac index and	10
may be responsible	10
of the endothelial	10
kidney injury in	10
acute phase response	10
are the main	10
linear regression analysis	10
fold increase in	10
was significantly increased	10
analysis was used	10
a retrospective observational	10
clinical trials in	10
was compared to	10
gram negative sepsis	10
trail and ip	10
presence of infection	10
blood loss and	10
disease severity and	10
number of days	10
care in the	10
to the hospital	10
of blood flow	10
septic patients were	10
to one of	10
had a mean	10
to elucidate the	10
to play an	10
we have shown	10
innovative therapies in	10
were higher than	10
were measured using	10
the problem of	10
it is known	10
ill septic patients	10
blood gas parameters	10
the early stages	10
and there was	10
be a promising	10
bei kritisch kranken	10
a p value	10
the ratio of	10
over the first	10
critical care unit	10
des septischen schocks	10
in the french	10
after sepsis induction	10
were significantly decreased	10
of a prospective	10
for septic patients	10
a logistic regression	10
of the acute	10
the probability of	10
in an in	10
the american college	10
and compared to	10
mechanisms involved in	10
a monoclonal antibody	10
acts as a	10
used in this	10
inferior vena cava	10
divided into groups	10
stages of the	10
for neonatal sepsis	10
data were compared	10
be able to	10
the case of	10
to participate in	10
is important for	10
results were compared	10
proinfl ammatory cytokines	10
at the level	10
circular rnas in	10
an improvement in	10
to the presence	10
performance of the	10
the immune status	10
the critical care	10
from the icu	10
a retrospective cohort	10
were taken from	10
isolated from the	10
group and the	10
performed using the	10
in the face	10
levels at h	10
have demonstrated that	10
have a significant	10
expression of a	10
patients has been	10
method for the	10
cell surface receptors	10
was assessed using	10
has been found	10
the three groups	10
ranged from to	10
on the presence	10
in all cases	10
patients with systemic	10
is also a	10
the secretion of	10
severe head injury	10
been shown in	10
of the liver	10
should be given	10
were significantly increased	10
response syndrome and	10
the mechanisms of	10
endothelial cells by	10
to a higher	10
a pivotal role	10
and adaptive immunity	10
of action of	10
the protective effect	10
care unit of	10
the first group	10
and negative predictive	10
analyses were performed	10
onset neonatal sepsis	10
leads to the	10
absence of a	10
results in a	10
icu in a	10
not affected by	10
survival rate in	10
of innate immune	10
result of a	10
of phage therapy	10
to understand the	10
neonatal intensive care	10
the survival rate	10
and production of	10
majority of the	10