bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
septic shock	990
intensive care	654
severe sepsis	612
critically ill	418
care unit	330
ill patients	322
mechanical ventilation	321
organ failure	296
inflammatory response	272
critical care	270
organ dysfunction	265
septic patients	265
endothelial cells	239
apache ii	221
ng ml	198
multiple organ	198
immune response	188
mg kg	186
patients admitted	184
pg ml	184
icu patients	181
nitric oxide	167
lung injury	156
icu admission	155
hospital mortality	148
control group	148
risk factors	147
immune system	145
two groups	143
necrosis factor	138
icu stay	133
significantly higher	133
ml kg	131
acute respiratory	131
mortality rate	125
neonatal sepsis	122
tumor necrosis	120
mean age	120
blood pressure	117
respiratory failure	115
blood flow	113
gene expression	112
respiratory distress	108
renal failure	108
systemic inflammatory	108
critical illness	107
ii score	106
day mortality	106
peripheral blood	104
observational study	103
sofa score	103
cardiac surgery	102
innate immune	101
response syndrome	101
arterial pressure	100
plasma levels	99
cardiac output	97
blood samples	96
significant difference	96
patienten mit	96
distress syndrome	96
trained immunity	94
acute lung	94
clinical trials	94
cytokine production	90
mechanically ventilated	89
significant differences	89
trauma patients	89
care units	87
cardiac arrest	87
statistically significant	87
infl ammatory	87
inflammatory cytokines	86
host response	86
patients undergoing	85
kidney injury	83
mortality rates	83
heart rate	82
mean arterial	82
reactive protein	82
like receptor	82
acute phase	81
arterial blood	81
adult patients	81
replacement therapy	80
present study	80
sepsis patients	79
acute kidney	78
adhesion molecules	78
endothelial cell	77
tidal volume	74
significantly lower	72
logistic regression	71
cohort study	71
university hospital	70
care medicine	70
inflammatory mediators	69
mg dl	69
cardiogenic shock	69
central venous	69
prospective study	69
statistical analysis	69
antibiotic therapy	68
hospital stay	68
whole blood	68
emergency department	68
renal replacement	68
significantly increased	67
patients received	67
bone marrow	66
dendritic cells	66
risk factor	65
icu mortality	64
myocardial infarction	64
healthy volunteers	64
oxygen delivery	64
shock patients	63
cell surface	62
study period	62
consecutive patients	62
patients without	62
blood cultures	61
increased risk	61
surviving sepsis	61
animal models	61
brain injury	60
immune cells	59
sepsis campaign	59
high risk	58
regression analysis	58
ventilated patients	58
body weight	56
ventilator dependence	56
increased mortality	55
significantly reduced	55
negative bacteria	55
clinical trial	55
bacterial infections	55
retrospective study	55
prospective observational	55
activated protein	55
systemic inflammation	54
may also	54
patients receiving	54
reactive oxygen	54
preterm infants	53
sepsis syndrome	53
acute renal	53
hemorrhagic shock	53
cardiac index	53
icu discharge	53
serum levels	52
tissue factor	52
onset sepsis	52
left ventricular	52
high levels	52
adaptive immune	52
fluid resuscitation	51
innate immunity	51
intravenous immunoglobulin	51
mm hg	50
immune responses	50
infectious diseases	50
data suggest	50
hospital discharge	49
host defense	49
mononuclear cells	49
survival rate	49
blood gas	49
high mortality	48
saps ii	48
surgical patients	48
bei patienten	48
adhesion molecule	48
acute myocardial	48
adverse events	48
monoclonal antibody	48
within hours	47
pulmonary artery	47
among patients	47
ml min	46
tissue damage	46
controlled trial	46
patients treated	45
birth weight	45
time points	45
cord uid	45
doc id	45
dysfunction syndrome	45
gram negative	44
drotrecogin alfa	44
growth factor	43
low birth	43
least one	43
cd cd	43
clinical practice	43
reperfusion injury	43
cell types	43
neutropenic patients	43
epithelial cells	43
respiratory rate	42
associated pneumonia	42
escherichia coli	42
may contribute	42
ammatory response	42
lung tissue	42
monoclonal antibodies	42
like receptors	41
oxygen saturation	41
bei der	41
acute pancreatitis	41
systematic review	41
performed using	41
der sepsis	41
important role	41
circular rnas	40
cell death	40
multivariate analysis	40
years old	40
blood cells	40
within days	40
first hours	40
tnf production	40
median age	40
und der	39
preterm neonates	39
heart failure	39
white blood	39
weight infants	39
blood cell	39
fl uid	39
tissue injury	39
cecal ligation	38
traumatic brain	38
pao fio	38
receptor antagonist	38
bacterial infection	38
neutropenic fever	38
renal function	38
may lead	38
inclusion criteria	38
kg min	38
ist die	38
predictive value	38
included patients	37
stimulating factor	37
united states	37
sepsis model	37
higher mortality	37
first days	37
bacterial translocation	37
study group	37
skeletal muscle	37
human sepsis	37
demographic data	37
mit einer	37
negative sepsis	36
recombinant human	36
primary outcome	36
dr expression	36
coronary artery	36
spontaneous breathing	36
bacterial sepsis	36
oxide synthase	36
blood loss	36
venous blood	36
burn injury	36
complement activation	36
results suggest	36
clinical outcome	36
randomized controlled	36
oxidative stress	36
proinfl ammatory	36
care patients	36
multicenter study	36
significant increase	35
urine output	35
und die	35
vascular resistance	35
clinical outcomes	35
infl ammation	35
red blood	35
blood culture	35
oxygen consumption	35
antimicrobial therapy	35
poor outcome	35
pseudomonas aeruginosa	35
significantly decreased	34
blood transfusion	34
long term	34
mast cells	34
results indicate	34
ex vivo	34
oxygen species	34
disease severity	34
respiratory tract	34
one patient	33
risk score	33
inflammatory responses	33
binding protein	33
organ damage	33
serum lactate	33
vascular permeability	33
detect sepsis	33
surgical icu	33
multiple trauma	33
clinical studies	33
significantly different	33
recent studies	33
improved survival	33
plasma concentrations	33
disseminated intravascular	33
major surgery	33
previous studies	32
informed consent	32
elderly patients	32
intravascular coagulation	32
smooth muscle	32
severe trauma	32
sepsis may	32
failure assessment	32
acute physiology	32
experimental sepsis	31
sepsis und	31
proinflammatory cytokines	31
flow cytometry	31
roc curve	31
statistical significance	31
cell adhesion	31
severe acute	31
thermal injury	31
blood mononuclear	31
blood glucose	31
injured patients	31
host immune	31
inflammatory reaction	31
animal studies	31
signal transduction	31
side effects	31
healthy controls	31
three groups	31
ischemia reperfusion	30
factors associated	30
receiver operating	30
plasminogen activator	30
immune function	30
clinical course	30
gabe von	30
cell activation	30
higher risk	30
may play	29
zu einer	29
tissue oxygenation	29
abdominal surgery	29
immune status	29
cytokine levels	29
consensus conference	29
organ injury	29
nosocomial infections	29
liver failure	29
protective effect	29
high dose	29
sepsis diagnosis	28
month period	28
normal saline	28
medical icu	28
abdominal sepsis	28
organ dysfunctions	28
phage therapy	28
herpes simplex	28
increased significantly	28
factor alpha	28
independent risk	28
polymicrobial sepsis	28
time point	28
year period	28
mit einem	28
pressure support	28
vascular endothelial	28
patients suffering	28
independently associated	28
bronchoalveolar lavage	28
peritoneal macrophages	27
early sepsis	27
health care	27
icu length	27
ethics committee	27
right ventricular	27
retrospective analysis	27
septic complications	27
lymph nodes	27
gas exchange	27
tidal volumes	27
complement system	27
measured using	27
low dose	27
patients died	27
early diagnosis	27
metabolic acidosis	27
injury severity	27
risk patients	27
nosocomial infection	27
patient care	27
staphylococcus aureus	27
und damit	27
animal model	27
nervous system	27
international guidelines	27
cytokine release	26
ug ml	26
determine whether	26
overall mortality	26
murine model	26
airway pressure	26
teaching hospital	26
organ system	26
sequential organ	26
study conducted	26
mit der	26
control animals	26
prolonged mechanical	26
significant correlation	26
obese patients	26
septischen schock	26
neutropenic sepsis	26
general icu	26
inflammatory cytokine	26
ards patients	26
burn patients	26
widely used	26
clinical signs	26
phase proteins	26
fluid administration	25
septic syndromes	25
following major	25
human monocytes	25
scoring system	25
wistar rats	25
fatty acids	25
severe septic	25
systemic vascular	25
pulmonary hypertension	25
inhalation injury	25
hydrogen peroxide	25
mouse model	25
barrier function	25
coagulation cascade	25
sepsis sensor	25
surgical intensive	25
postoperative period	25
increased expression	25
type i	25
operating characteristic	25
urinary tract	25
nk cells	24
significant reduction	24
previously reported	24
cardiopulmonary bypass	24
acquired pneumonia	24
ozone therapy	24
sepsis septic	24
ejection fraction	24
adaptive immunity	24
class ii	24
associated molecular	24
viral infections	24
lps challenge	24
simplex virus	24
first time	24
hemodynamic parameters	24
beneficial effects	24
patients presenting	24
early goal	24
durch eine	24
improves survival	24
may result	24
cell lines	24
group i	24
enteral nutrition	24
age years	24
body temperature	24
heat shock	23
mean values	23
positive bacteria	23
tlr agonists	23
confidence interval	23
durch die	23
hospital cardiac	23
auf die	23
emergency room	23
early stage	23
suspected infection	23
may improve	23
admission day	23
crp levels	23
prospective cohort	23
five patients	23
cancer patients	23
hospital admission	23
serum creatinine	23
term neonates	23
molecular mechanisms	23
well known	23
clinical data	23
commonly used	23
human endothelial	23
traumatic injury	23
retrospective cohort	23
membrane oxygenation	23
th cells	23
circular rna	23
patients requiring	23
multiorgan failure	23
compared using	23
lactate levels	23
two patients	22
hospital length	22
transforming growth	22
infectious complications	22
stroke volume	22
significant decrease	22
study showed	22
data indicate	22
time course	22
therapeutic interventions	22
high doses	22
acute illness	22
soluble tnf	22
group received	22
kommt es	22
lower mortality	22
antithrombin iii	22
vena cava	22
medical intensive	22
newborn infants	22
central nervous	22
head injury	22
inflammatory process	22
general hospital	22
immune cell	22
rat model	22
cell function	22
analysis showed	22
parenteral nutrition	22
odontogenic infections	22
von der	22
alveolar macrophages	22
dependence risk	22
continuous infusion	22
lg ml	22
positive correlation	22
cell proliferation	21
preliminary results	21
beneficial effect	21
extracorporeal membrane	21
collected data	21
fluid balance	21
fluid challenge	21
exclusion criteria	21
endotoxic shock	21
major role	21
normal range	21
studied patients	21
einsatz von	21
icu admissions	21
regression model	21
pilot study	21
pulmonary edema	21
cell count	21
mean apache	21
venous pressure	21
surgical trauma	21
wound healing	21
directed therapy	21
auch die	21
mg ml	21
platelet count	21
mixed venous	21
activating factor	21
adult respiratory	21
fungal infections	21
results showed	21
lipid peroxidation	21
intravascular volume	21
invasive mechanical	21
increased levels	21
severity score	21
data collection	21
considered significant	21
septischem schock	21
per day	21
transcription factor	21
ali ards	20
patients developed	20
septic animals	20
ill patient	20
sofa scores	20
kritisch kranken	20
improve survival	20
cd expression	20
cord blood	20
natural killer	20
severely ill	20
serum il	20
blood gases	20
study included	20
kg day	20
intracranial pressure	20
hemodynamic instability	20
patient outcome	20
enrolled patients	20
therapeutic approaches	20
emergency medicine	20
endothelial dysfunction	20
low levels	20
new therapeutic	20
organ failures	20
th day	20
bei einem	20
immune globulin	20
free radicals	20
clinical study	20
higher levels	20
prognostic value	20
odds ratio	20
cardiopulmonary resuscitation	19
risk stratification	19
patients underwent	19
necrotizing enterocolitis	19
one hour	19
baseline characteristics	19
cd cells	19
cell wall	19
invasive ventilation	19
plasma samples	19
may provide	19
increased survival	19
sepsis group	19
pulmonary vascular	19
dependent manner	19
antibiotic treatment	19
significant improvement	19
decision making	19
expression profiles	19
systemic infl	19
apache iii	19
kardiogenem schock	19
die gabe	19
mrna expression	19
infectious disease	19
total body	19
protective effects	19
free radical	19
first day	19
significantly improved	19
treated patients	19
intercellular adhesion	19
treated animals	19
poor prognosis	19
well tolerated	19
patients may	19
tissue perfusion	19
chronic health	19
circulatory failure	19
may help	19
vital signs	19
partial pressure	19
molecular biology	19
assessed using	19
growth hormone	19
sirs criteria	19
clinical significance	18
physiology score	18
ventilatory support	18
blood levels	18
results show	18
septic response	18
significantly correlated	18
lactic acidosis	18
standard deviation	18
inhibitory effect	18
induced lung	18
artery bypass	18
chest pain	18
leading cause	18
surgical procedures	18
pediatric sepsis	18
therapeutic intervention	18
pulse pressure	18
fold increase	18
type ii	18
also found	18
vitro studies	18
cardiac function	18
music therapy	18
tnf receptor	18
central role	18
der patienten	18
mobility group	18
predict mortality	18
carbon monoxide	18
system failure	18
significantly associated	18
major cause	18
organ function	18
bacterial clearance	18
infected patients	18
high concentrations	18
health evaluation	18
average age	18
neutrophil activation	18
venous catheter	18
ammatory cytokines	18
following trauma	18
aki stage	18
per patient	18
activated neutrophils	18
study aimed	18
head trauma	18
investigate whether	18
ang ii	18
study design	18
randomly assigned	18
key role	18
activator inhibitor	18
median time	18
liver disease	18
tumour necrosis	17
base excess	17
im vergleich	17
tnf receptors	17
myeloid cells	17
surface area	17
underlying disease	17
shed blood	17
human septic	17
endothelial damage	17
cardiac dysfunction	17
without sepsis	17
nicht nur	17
receptor expression	17
molecular patterns	17
dna methylation	17
prospective randomized	17
mesenteric lymph	17
days post	17
endothelial permeability	17
determined using	17
abdominal infection	17
sepsis timeline	17
international consensus	17
mortality risk	17
fluid responsiveness	17
capillary permeability	17
cytokine storm	17
prospectively collected	17
bacterial growth	17
high sensitivity	17
icu staff	17
protein synthesis	17
treated group	17
experimental studies	17
may occur	17
pct levels	17
wide range	17
granulocyte colony	17
sepsis study	17
day survival	17
glucose control	17
univariate analysis	17
major trauma	17
normal values	17
marrow transplantation	17
square test	17
lactic acid	17
phagocytic cells	17
highly significant	17
mast cell	17
late sepsis	17
blood products	17
serum samples	17
whitney test	17
female mice	17
ii scores	17
septic patient	17
group box	17
one year	17
werden kann	17
third international	17
intensive insulin	17
fluid infusion	17
myocardial dysfunction	17
tissue hypoxia	17
postoperative day	17
circulating igm	17
positive blood	17
auf eine	16
randomized trial	16
linear regression	16
viral infection	16
real time	16
remains unclear	16
medical patients	16
frequently used	16
hemodynamic changes	16
observation period	16
prognostic factors	16
short term	16
intravenous immunoglobulins	16
clinical presentation	16
proinflammatory cytokine	16
kupffer cells	16
written informed	16
body mass	16
suspected sepsis	16
reports suggest	16
early phase	16
fi ndet	16
initial resuscitation	16
cell line	16
center study	16
group compared	16
life support	16
virus infection	16
male wistar	16
major abdominal	16
oxygen radicals	16
supine position	16
amino acid	16
sepsis remains	16
severity scores	16
may influence	16
non invasive	16
blood sampling	16
clinical setting	16
medical records	16
pulmonary disease	16
critical role	16
controlled trials	16
results demonstrate	16
patients compared	16
artery disease	16
plasma endotoxin	16
peritoneal cavity	16
positive effects	16
patients showed	16
patients required	16
differ significantly	16
inflammatory processes	16
therapeutic approach	16
adverse effects	16
cytokine response	16
common cause	16
insulin therapy	16
single cell	16
endotoxin levels	16
identify patients	16
heart surgery	16
auf der	16
pct level	16
may explain	16
leukocyte antigen	16
immunoglobulin therapy	16
glasgow coma	16
six patients	16
creatinine clearance	16
experimental models	16
patient outcomes	16
scoring systems	16
tnf levels	16
seven patients	16
onset neonatal	16
term mortality	16
acute liver	16
controlled study	15
analysed using	15
studies will	15
acute care	15
septic rats	15
tract infection	15
sepsis definitions	15
significantly elevated	15
smartcare ps	15
broad spectrum	15
therapeutic agents	15
inducible nitric	15
clinically relevant	15
total number	15
chronic disease	15
died within	15
signaling pathways	15
sepsis management	15
inflammatory mediator	15
decreased significantly	15
clinical features	15
microvascular endothelial	15
liver cirrhosis	15
multivariate logistic	15
airway management	15
antimicrobial peptides	15
growth factors	15
way anova	15
studies suggest	15
clinical sepsis	15
transplant recipients	15
tract infections	15
ct scan	15
carbon dioxide	15
dental practice	15
large number	15
cardiac surgical	15
activated macrophages	15
increased susceptibility	15
gold standard	15
nuclear factor	15
expiratory pressure	15
mortality prediction	15
plasma concentration	15
patient safety	15
immune activation	15
rats subjected	15
case report	15
study shows	15
clinical characteristics	15
exact test	15
dawley rats	15
negative predictive	15
neutrophil extracellular	15
patient population	15
low doses	15
sepsis cohort	15
vascular tone	15
fio ratio	15
factor pathway	15
systolic blood	15
septic group	15
und bei	15
als auch	15
placebo group	15
positive end	15
following injury	15
endotracheal tube	14
resistant bacteria	14
des septischen	14
early recognition	14
lipid mediators	14
muscle cells	14
elevated renin	14
two different	14
ko mice	14
kg hr	14
fluid management	14
four patients	14
income countries	14
severe head	14
randomized study	14
pediatric septic	14
treatment group	14
year mortality	14
immunodeficiency virus	14
candida albicans	14
human immunodeficiency	14
fatal outcome	14
neurologic outcome	14
severe ards	14
hemodynamic support	14
icu population	14
macrophage polarization	14
severe infections	14
treatment groups	14
tertiary care	14
extracellular matrix	14
fold higher	14
even though	14
icu setting	14
der regel	14
cell type	14
supportive care	14
burned patients	14
necrotizing pancreatitis	14
immune dysfunction	14
term outcome	14
induced acute	14
groups according	14
pathway inhibitor	14
macrophage activation	14
auch bei	14
group ii	14
willebrand factor	14
cell injury	14
inflammatory diseases	14
kardiogenen schock	14
streptococcus pneumoniae	14
human leukocyte	14
soft tissue	14
primary endpoint	14
elevated levels	14
kardiogenen schocks	14
umbilical vein	14
fi rst	14
statistically different	14
three times	14
higher incidence	14
lg kg	14
patients needed	14
combination therapy	14
body surface	14
sepsis induced	14
ist eine	14
showed significant	14
pulmonary arterial	14
surface expression	14
pivotal role	14
tlr agonist	14
lactate level	14
low cardiac	14
human umbilical	14
early identification	14
analysis revealed	14
interquartile range	14
mv duration	14
protein kinase	14
different types	14
documented infection	14
randomized clinical	14
mediated immunity	14
generally accepted	14
acute organ	14
antigen presentation	14
table shows	14
colony stimulating	14
molecular weight	14
computed tomography	14
lung cancer	14
expression profiling	14
study aims	14
ndet sich	14
retrospective observational	14
breathing trial	14
potential therapeutic	14
three days	14
sepsis induction	14
ml saline	14
coagulation factors	14
mhc class	14
acute brain	14
may increase	14
mucosal barrier	14
baseline values	14
early warning	14
predicted mortality	14
assessment method	13
sham operation	13
blood transfusions	13
control patients	13
myocardial depression	13
endothelial function	13
thrombin generation	13
pediatric patients	13
fluid therapy	13
sepsis biomarkers	13
induced cytokine	13
effector cells	13
surface receptors	13
acute inflammatory	13
sepsis mortality	13
plasmacytoid dendritic	13
cells may	13
levels increased	13
brain barrier	13
first line	13
respiratory syndrome	13
arachidonic acid	13
inflammatory markers	13
phase ii	13
rats treated	13
monocyte deactivation	13
american college	13
severe tbi	13
endothelium dependent	13
patients included	13
brain dysfunction	13
united kingdom	13
significant changes	13
des mods	13
bacterial load	13
piro system	13
recognition receptors	13
und eine	13
probably due	13
patients following	13
patients presented	13
surgery patients	13
undergoing cardiac	13
polymerase chain	13
survival rates	13
von willebrand	13
iu kg	13
patient groups	13
consensus definitions	13
control subjects	13
icu patient	13
patients hospitalized	13
per group	13
severely injured	13
hemodynamic monitoring	13
lps stimulation	13
lps group	13
free days	13
university hospitals	13
cell responses	13
circulating neutrophils	13
ventilator associated	13
i levels	13
gut barrier	13
coagulation system	13
phase response	13
increased cardiac	13
inspired oxygen	13
gestational age	13
lps injection	13
protein levels	13
inflammatory cells	13
findings suggest	13
induced shock	13
treated mice	13
liver transplantation	13
kg bw	13
data collected	13
negative infections	13
contact system	13
experimental animals	13
stem cell	13
traumatic stress	13
subarachnoid hemorrhage	13
total rna	13
complicating acute	13
improve outcomes	13
three different	13
acute coronary	13
der einsatz	13
patients will	13
increased vascular	13
patients using	13
small intestine	13
human volunteers	13
low tidal	13
signifi cantly	13
serum concentrations	13
first week	13
prowess trial	13
medical care	13
bloodstream infection	13
und das	13
positive results	13
common complication	13
capillary leak	13
mitochondrial dysfunction	13
phase iii	13
diabetes mellitus	13
western blotting	13
treated rats	13
cell apoptosis	13
simplified acute	13
percutaneous tracheostomy	13
clinical manifestations	13
coma scale	13
phagocytic activity	13
clinical use	13
adult icu	13
also measured	12
leukocyte adhesion	12
internal jugular	12
two days	12
cox regression	12
hospitalized patients	12
schock und	12
severe systemic	12
postoperative complications	12
nursing care	12
des patienten	12
bacterial pneumonia	12
extracellular traps	12
evaluation ii	12
therapie der	12
myocardial ischemia	12
shock may	12
tnf release	12
physical function	12
time pcr	12
ideal body	12
current study	12
control groups	12
macrophage cell	12
expression levels	12
mass index	12
sepsis onset	12
data analysis	12
healthy subjects	12
cellular injury	12
plasma il	12
group showed	12
drug interactions	12
international sepsis	12
sepsis severity	12
mortality among	12
fecal peritonitis	12
major injury	12
longer hospital	12
vascular smooth	12
bis zu	12
deleterious effects	12
survival time	12
one hundred	12
twice daily	12
high affinity	12
cause mortality	12
high incidence	12
murine sepsis	12
much higher	12
mental status	12
mouse blood	12
lung compliance	12
venous oxygen	12
positive pressure	12
oxygen extraction	12
clinical parameters	12
oxygen free	12
acutely ill	12
endotoxin infusion	12
human studies	12
im septischen	12
lower respiratory	12
ill adults	12
may serve	12
tnf mab	12
icu los	12
arterial oxygen	12
bypass grafting	12
differentially expressed	12
developing countries	12
gastrointestinal tract	12
adverse outcomes	12
uric acid	12
suppressor cells	12
single center	12
pulmonary infection	12
clot microstructure	12
sepsis pathophysiology	12
nursing staff	12
receive either	12
many patients	12
three patients	12
mcg kg	12
prognostic marker	12
hours following	12
natriuretic peptide	12
days later	12
vergleich zu	12
better understanding	12
monocytes macrophages	12
schwerer sepsis	12
coronary angiography	12
ecmo support	12
lps administration	12
following hs	12
several studies	12
dendritic cell	12
every patient	12
recently shown	12
negative bacterial	12
kann die	12
also known	12
mit septischem	12
bacterial challenge	12
surgical wards	12
endothelial activation	12
baseline levels	12
macrophage colony	12
mitochondrial function	12
calculated using	12
nutritional support	12
final outcome	12
following sepsis	12
perfusion pressure	12
bactericidal permeability	12
gender differences	12
rater reliability	12
hoc analysis	12
endotoxin tolerance	12
rv function	12
commercially available	12
herzinsuffi zienz	12
one group	12
blind study	12
electronic health	12
chain reaction	12
medical center	12
clinical criteria	12
converting enzyme	12
pulmonary complications	12
medical students	12
controlled clinical	12
extremely low	12
early stages	12
early detection	12
uid resuscitation	12
lavage fluid	12
sample size	12
pressure variation	12
vascular endothelium	12
least two	11
um die	11
related infection	11
spontaneous circulation	11
icu survivors	11
grant acknowledgment	11
shock trial	11
defined according	11
respiratory system	11
requiring mechanical	11
one episode	11
lung disease	11
ventricular function	11
statistical differences	11
mechanisms involved	11
control mice	11
first step	11
blood lactate	11
linked immunosorbent	11
portal vein	11
vein endothelial	11
pathogen recognition	11
patient group	11
helper cell	11
abscess formation	11
hours post	11
classified according	11
fatty acid	11
also associated	11
care physicians	11
days mortality	11
phase trial	11
early albumin	11
flow rate	11
investigated whether	11
previous study	11
intravenous injection	11
ml lps	11
new onset	11
volume expansion	11
atrial fibrillation	11
patients often	11
protein expression	11
im falle	11
reactive nitrogen	11
intravenous immune	11
also present	11
kgkg min	11
experimental model	11
first group	11
infl ammasome	11
severe traumatic	11
study population	11
current guidelines	11
systemic circulation	11
stress response	11
vasopressor therapy	11
mit dem	11
higher concentrations	11
induced immunosuppression	11
data set	11
prognostic factor	11
clinical research	11
prospectively studied	11
missing data	11
experimental study	11
cell transplantation	11
blood sample	11
data showed	11
blood stream	11
durch den	11
tertiary referral	11
post hoc	11
umbilical cord	11
mit kardiogenem	11
premature infants	11
oxygen supply	11
septic mice	11
circulating levels	11
study entry	11
serum albumin	11
patient demographics	11
cognitive impairment	11
animals treated	11
therapeutic target	11
studies demonstrated	11
pleural effusion	11
es zu	11
recent years	11
increased incidence	11
acute inflammation	11
progenitor cells	11
defi ned	11
kidney disease	11
die prognose	11
single nucleotide	11
chronic dysglycemia	11
endothelial injury	11
apoptotic cell	11
increased plasma	11
age range	11
potential role	11
higher doses	11
endotoxin induced	11
shock protein	11
neonatal bacterial	11
therapeutic strategies	11
gram positive	11
anstieg des	11
post cpb	11
xanthine oxidase	11
chronic liver	11
early postoperative	11
enriched immunoglobulin	11
cell populations	11
significant higher	11
recent study	11
control values	11
two hours	11
chronic renal	11
surgical intervention	11
glucose uptake	11
sepsis incidence	11
currently available	11
term survival	11
positive effect	11
high level	11
rapid response	11
innerhalb der	11
superior vena	11
altman analysis	11
cellular immune	11
respiratory function	11
liver resection	11
plasma tnf	11
median values	11
remains high	11
ventricular dysfunction	11
adrenal insufficiency	11
refractory shock	11
factor receptor	11
control study	11
blood monocytes	11
vitro experiments	11
breast cancer	11
will help	11
stranded rna	11
systemic response	11
intracranial hypertension	11
general anesthesia	11
reduce mortality	11
bl mice	11
inhibitor type	11
mg kgkg	11
four hours	11
microbiologically documented	11
well established	11
defense mechanisms	11
liver function	11
cytokine antagonists	11
human activated	11
spezifi sche	11
useful tool	11
blood volume	11
cardiac arrests	11
secondary outcomes	11
diagnostic performance	11
deficient mice	11
dysregulated host	11
mean duration	11
sepsis bundles	11
correlation coefficient	11
noch nicht	11
male mice	11
jugular vein	11
roc curves	11
oxygen transport	11
pulmonary embolism	11
endotoxin shock	11
correlated well	11
volume resuscitation	11
intestinal ischemia	11
lethal dose	11
comorbidity index	11
may reduce	10
identifying patients	10
tertiary hospital	10
postoperative sepsis	10
ist bei	10
amino acids	10
disease process	10
may reflect	10
der ersten	10
lps induced	10
bei kritisch	10
cell membrane	10
success rate	10
enteral feeding	10
ill septic	10
continuous renal	10
presenting cells	10
cell counts	10
im rahmen	10
community acquired	10
hospital los	10
iu ml	10
ist der	10
inferior vena	10
und sepsis	10
related organ	10
hours later	10
laboratory tests	10
vlbw infants	10
lymphoid cells	10
nine patients	10
valve replacement	10
serum procalcitonin	10
emergency departments	10
clinical observations	10
premature neonates	10
cell dysfunction	10
surface markers	10
total parenteral	10
mediator release	10
data obtained	10
significantly greater	10
case reports	10
kg i	10
hand hygiene	10
coli sepsis	10
life expectancy	10
copy number	10
magic bullets	10
health record	10
organ systems	10
respiratory mechanics	10
hemodynamic variables	10
significant role	10
arterial catheter	10
protective role	10
sepsis decision	10
detection limit	10
mediated immune	10
independent predictors	10
treating sepsis	10
statistically significantly	10
also significantly	10
ist ein	10
decreased mortality	10
haemorrhagic shock	10
adjunctive therapy	10
confusion assessment	10
hepatic dysfunction	10
worse outcome	10
lithium chloride	10
antibiotic use	10
frozen plasma	10
hospital acquired	10
sublingual microcirculation	10
outcome data	10
diagnostic criteria	10
programmed death	10
following surgical	10
defi nitions	10
circulating monocytes	10
host resistance	10
bacterial colonization	10
levels may	10
glucose levels	10
mortality following	10
term infants	10
see table	10
produce cytokines	10
immune defense	10
demographic characteristics	10
ammonia clearance	10
randomised controlled	10
consecutive days	10
febrile neutropenia	10
gas parameters	10
blood sugar	10
single centre	10
dependent relaxation	10
bacterial products	10
four groups	10
epithelial cell	10
remained stable	10
human neutrophils	10
previously described	10
intestinal mucosa	10
increased morbidity	10
serum amyloid	10
hcv patients	10
innovative therapies	10
circulating blood	10
care med	10
extubation failure	10
diagnose sepsis	10
clinical decision	10
animals received	10
complement proteins	10
mass spectrometry	10
tissue oxygen	10
ethical committee	10
endothelial barrier	10
pulse contour	10
clinical management	10
studies indicate	10
complications associated	10
im schock	10
every hours	10
outcome measure	10
linear rna	10
studies using	10
positive organisms	10
first period	10
endotracheal intubation	10
mit sepsis	10
committee approval	10
toward th	10
human blood	10
edema formation	10
human peripheral	10
prospective multicenter	10
medical university	10
sind die	10
per se	10
ecmo circuit	10
die sich	10
zu den	10
und des	10
human spleen	10
higher rate	10
resident macrophages	10
surgical procedure	10
lps binding	10
early administration	10
intubated patients	10
kg body	10
identifi ed	10
ward patients	10
hypertonic saline	10
patients discharged	10
infl uence	10
small bowel	10
shock group	10
immune systems	10
shock proteins	10
may affect	10
also increased	10
neonatal intensive	10
data show	10
artery catheter	10
bei sepsis	10
serum iron	10
neutrophil recruitment	10
host defenses	10
characteristic curve	10
gel electrophoresis	10
ten patients	10
dynamic range	10
fluid removal	10
prone position	10
threatening condition	10
septischen schocks	10
may cause	10
severe forms	9
tissue edema	9
complement cascade	9
picco tm	9
physician collaboration	9
induced tnf	9
tissue plasminogen	9
uncomplicated sepsis	9
healthy individuals	9
results may	9
patient characteristics	9
clostridium difficile	9
cell mediated	9
guidelines recommend	9
abnahme des	9
patients ventilated	9
procoagulant activity	9
cells mm	9
trauma system	9
physical examination	9
anaerobic metabolism	9
hematopoietic stem	9
elective cardiac	9
campaign guidelines	9
polymorphonuclear leukocytes	9
neben der	9
met sepsis	9
took place	9
profi le	9
peripheral vascular	9
respiratory infection	9
cognitive decline	9
increases survival	9
molecule expression	9
feedback function	9
including sepsis	9
hazard ratio	9
genes involved	9
among others	9
mean value	9
healthy donors	9
significant risk	9
severe community	9
viral sepsis	9
immune suppression	9
der notaufnahme	9
phagocytic function	9
piro concept	9
single dose	9
weaning process	9
energy metabolism	9
last years	9
grant acknowledgement	9
ct scans	9
mitochondrial respiration	9
high mobility	9
fibrin deposition	9
hematologic malignancies	9
trial registry	9
taken together	9
apoptotic cells	9
myocardial injury	9
novel therapeutic	9
human neutrophil	9
cortisol levels	9
days following	9
myeloid differentiation	9
target range	9
following hemorrhage	9
immunoglobulin preparation	9
ng gwt	9
lymphocyte apoptosis	9
sepsis models	9
reference method	9
treatment option	9
capillary density	9
early treatment	9
medical school	9
superior mesenteric	9
closely related	9
increased cd	9
analyzed using	9
right ventricle	9
blood plasma	9
mann whitney	9
inflammatory pathways	9
survival group	9
serine protease	9
protease inhibitors	9
recent clinical	9
fluid bolus	9
ventilator settings	9
clinical severity	9
later time	9
heart disease	9
neutrophil elastase	9
genetic polymorphisms	9
transit time	9
type cells	9
one third	9
vivo studies	9
induced changes	9
tyrosine kinase	9
prolonged ventilator	9
pressure ventilation	9
cell receptor	9
using high	9
wedge pressure	9
study including	9
median apache	9
left ventricle	9
mrna levels	9
following lps	9
cellular damage	9
renal dysfunction	9
brain trauma	9
gap junctions	9
admission diagnosis	9
also observed	9
sepsis treatment	9
alternative splicing	9
microvascular blood	9
functional status	9
signifi cant	9
crucial role	9
elevated serum	9
increased serum	9
system may	9
cell transfusion	9
antibiotic prophylaxis	9
fresh frozen	9
ivig preparations	9
animal experiments	9
septic critically	9
squared test	9
including patients	9
increased il	9
patients submitted	9
clinical frailty	9
fi nden	9
dose dependent	9
mechanisms underlying	9
similar results	9
improve outcome	9
following severe	9
reducing mortality	9
mean sem	9
spectrum antibiotics	9
seven days	9
trend toward	9
shockable rhythm	9
bactericidal activity	9
als folge	9
assess whether	9
past years	9
tissue repair	9
specific antibodies	9
first months	9
activated pmns	9
recent data	9
sondern auch	9
weight neonates	9
strongly associated	9
two major	9
neonatal infections	9
human disease	9
amniotic fluid	9
mehr als	9
sepsis diagnostic	9
med doi	9
one hand	9
time period	9
response rate	9
post lps	9
days vs	9
citrate anticoagulation	9
several factors	9
tlr activation	9
increasing protein	9
systemic oxygen	9
phase protein	9
sodium bicarbonate	9
significant association	9
ventricular septal	9
oxygen tension	9
baseline risk	9
hydroxyethyl starch	9
mesenteric artery	9
antimicrobial resistance	9
kg iv	9
infrared spectroscopy	9
respiratory support	9
lymph flow	9
chi square	9
remaining patients	9
small sample	9
adverse outcome	9
und ein	9
albumin infusion	9
group iii	9
transfusion requirements	9
risk assessment	9
underlying diseases	9
internal medicine	9
liver injury	9
neonatal mortality	9
shock complicating	9
zu einem	9
shock treated	9
mixed medical	9
general wards	9
total protein	9
trauma sepsis	9
routine use	9
selected patients	9
pooled plasma	9
better outcomes	9
dysfunction score	9
infected neonates	9
severe infection	9
patients years	9
protein concentration	9
patients suffered	9
crude mortality	9
septic plasma	9
randomized trials	9
positive predictive	9
classifi cation	9
phages may	9
crit care	9
muscle strength	9
two types	9
ventricular ejection	9
future studies	9
induced inflammation	9
ascitic fluid	9
aortic balloon	9
clinical conditions	9
glycemic control	9
hemodynamic effects	9
phase reaction	9
acinetobacter baumannii	9
may represent	9
intestinal motility	9
results obtained	9
low concentrations	9
immune functions	9
intraabdominal pressure	9
synthesis inhibitor	9
related mortality	9
median value	9
aki patients	9
bacterial lipopolysaccharide	9
respiratory burst	9
produce il	9
host inflammatory	9
purpura fulminans	9
experimental animal	9
associated costs	9
elective surgery	9
surgical complications	9
prothrombin time	9
poor outcomes	9
lysosomal enzymes	9
patients whose	9
different groups	9
microbial invasion	9
nosocomial sepsis	9
icp monitoring	9
hemoperfusion cartridge	9
inotropic support	9
neurological complications	9
human plasma	9
charlson comorbidity	9
delayed hypersensitivity	9
primary care	8
enriched immunoglobulins	8
chronic diseases	8
eol care	8
available evidence	8
sepsis using	8
hematological malignancies	8
new method	8
immune deficiency	8
soluble icam	8
kritisch kranker	8
csf treatment	8
stage renal	8
pulmonary oedema	8
lung water	8
aortic endothelial	8
also recorded	8
arterial hypotension	8
high tidal	8
received either	8
ecmo patients	8
care doi	8
bacterial cell	8
inpatient care	8
chronic kidney	8
conducted using	8
hypovolemic shock	8
matrix proteins	8
percutaneous coronary	8
oxygen partial	8
infusion rate	8
polymorphonuclear neutrophils	8
female bmdms	8
antimicrobial treatment	8
expiratory flow	8
gene transcription	8
reduced expression	8
multiorgan dysfunction	8
therapeutic effect	8
splenic macrophages	8
icu nurses	8
new biomarkers	8
kann durch	8
immunosorbent assay	8
coli endotoxin	8
cell viability	8
increased pulmonary	8
schock ist	8
systemic lupus	8
inhibitory factor	8
factor expression	8
neonatal infection	8
daily living	8
will need	8
cardiovascular dysfunction	8
shock states	8
kann es	8
neutrophil count	8
caloric intake	8
dysfunction failure	8
producing cells	8
superoxide dismutase	8
confidence intervals	8
samples taken	8
promising results	8
killer cells	8
hepatic failure	8
minute ventilation	8
tight glucose	8
significantly less	8
induced trained	8
splice site	8
serum igm	8
myocardial function	8
ist das	8
significant increases	8
new interventions	8
categorical data	8
monocyte il	8
developed septic	8
sepsis sepsis	8
good correlation	8
group without	8
secondary care	8
postoperative infection	8
clinical syndrome	8
patients scheduled	8
nitrite nitrate	8
infarction complicated	8
ats sis	8
cells produce	8
bedside review	8
mental health	8
syndrome coronavirus	8
abdominal aortic	8
serum tnf	8
bei kardiogenem	8
therapeutic hypothermia	8
kg ideal	8
rat liver	8
human endotoxemia	8
sccm esicm	8
effi cacy	8
plasma level	8
patients affected	8
mortality compared	8
new therapies	8
pediatric population	8
matrix metalloproteinase	8
accp ats	8
negative bacteremia	8
high dependency	8
global mortality	8
lung epithelial	8
mg iv	8
tight junction	8
using spss	8
medical staff	8
general population	8
blood bank	8
oxygen utilization	8
cardiac slices	8
mortality benefit	8
blood group	8
curve analysis	8
one point	8
depressive mood	8
definitions conference	8
room temperature	8
median icu	8
laboratory findings	8
venous ecmo	8
patients diagnosed	8
will provide	8
unit patients	8
study fluids	8
septischer schock	8
shear stress	8
analysis demonstrated	8
control rats	8
stimulation test	8
surviving patients	8
related factors	8
end points	8
clot formation	8
bacterial toxins	8
routinely used	8
acquired infection	8
without delay	8
mean time	8
severe injury	8
onset severe	8
systolic pressure	8
adult icus	8
po fio	8
support ventilation	8
also evaluated	8
gut flora	8
second day	8
bacteraemic episodes	8
patients met	8
evaluated using	8
chart review	8
differential expression	8
structural empowerment	8
manual hyperinflation	8
wide variety	8
activation markers	8
und septischem	8
studies showed	8
promoter region	8
hiv aids	8
early onset	8
stress doses	8
negative correlation	8
chronic critical	8
second group	8
facs analysis	8
cmv infection	8
false positive	8
tg kg	8
task force	8
dead space	8
although many	8
predictive values	8
cytokine profile	8
cardiac failure	8
patient samples	8
abnormal rv	8
better outcome	8
immunoglobulin replacement	8
urea nitrogen	8
continuous intravenous	8
bei den	8
nk cell	8
vascular occlusion	8
mitralinsuffi zienz	8
cell response	8
trend towards	8
severe respiratory	8
fourteen patients	8
studies show	8
median number	8
patients infected	8
patients enrolled	8
indian subset	8
vascular bed	8
macrophage migration	8
phase i	8
magnesium sulphate	8
different doses	8
full thickness	8
much lower	8
persistent pulmonary	8
double blind	8
oleic acid	8
clinical evidence	8
sepsis date	8
prostaglandin synthesis	8
der wahl	8
circulating il	8
relative risk	8
second study	8
cognitive dysfunction	8
spleen cells	8
ventilator days	8
chronic inflammatory	8
resistant enterococcus	8
illness polyneuromyopathy	8
human il	8
pressure monitoring	8
lung regions	8
main cause	8
sich bei	8
classifi ed	8
resuscitation bundle	8
pediatric intensive	8
general surgery	8
care admission	8
study suggests	8
binding lectin	8
hemodynamic response	8
widespread use	8
lv function	8
systolic function	8
intraperitoneal injection	8
early enteral	8
sepsis development	8
carotid artery	8
impaired oxygen	8
severity scoring	8
whole body	8
allogeneic blood	8
elevated plasma	8
shock due	8
log rank	8
organ perfusion	8
retrospectively reviewed	8
initially treated	8
showed significantly	8
interferon gamma	8
remained unchanged	8
helper cells	8
stress ulcers	8
perceived hopelessness	8
emergency surgery	8
vasopressor exposure	8
may include	8
authors declare	8
first postoperative	8
obstructive pulmonary	8
coagulation activation	8
review board	8
consecutive adult	8
improving outcomes	8
interstitial lung	8
antibiotic resistance	8
chronic obstructive	8
radical production	8
autologous blood	8
therapeutic potential	8
graft infection	8
negative blood	8
survive sepsis	8
des herzens	8
wallis test	8
multiple comparisons	8
hour survival	8
refractory septic	8
ct head	8
available data	8
cell population	8
lps receptor	8
bacterial endotoxin	8
ammonia levels	8
prospective studies	8
damit eine	8
multidisciplinary team	8
die diagnose	8
protective immunity	8
host responses	8
authors concluded	8
germany critical	8
jedoch nicht	8
nos inhibitor	8
septic state	8
reduced mortality	8
intravenous infusion	8
inflammatory properties	8
adversely affect	8
gastric emptying	8
aber auch	8
esicm accp	8
sepsis risk	8
ml respectively	8
renal impairment	8
autoimmune diseases	8
culture medium	8
serum pct	8
two dimensional	8
patients developing	8
time interval	8
listeria monocytogenes	8
function following	8
lung protective	8
age group	8
preclinical studies	8
intravenous administration	8
diastolic function	8
study patients	8
blood coagulation	8
circulating cytokines	8
repeated measures	8
ros generation	8
relatively low	8
independent predictor	8
vein thrombosis	8
sepsis also	8
observational cohort	8
das auftreten	8
acute necrotizing	8
operative day	8
severe brain	8
acute circulatory	8
nden sich	8
alcohol abuse	8
mit schwerer	8
data base	8
microvascular permeability	8
synthase inhibitor	8
protein level	8
severe hypoxemia	8
tlr signaling	8
energy expenditure	8
protease inhibitor	8
sex ratio	8
macrophage inflammatory	8
sis international	8
measured daily	8
extracorporeal circulation	8
programmed cell	8
gene products	8
patients meeting	8
defi nition	8
continuous data	8
vasoactive drugs	8
negative organisms	8
clinical evaluation	8
multivariable logistic	8
pain management	8
may predict	8
data regarding	8
icu care	8
lymphocyte function	8
solid organ	8
first study	8
possible role	8
pulsatility index	8
early mortality	8
group treated	8
vitro stimulation	8
inflammatory protein	8
endotracheal suctioning	8
epidemiological data	8
bacteraemic sepsis	8
excluded patients	8
clotting factors	8
one patients	8
immune mechanisms	8
blood leukocytes	8
ventilation strategy	8
tbi patients	8
endothelial surface	8
late phase	8
cd antigen	7
standard therapy	7
congestive heart	7
serious adverse	7
des kardiogenen	7
durch einen	7
negative infection	7
gapdh activity	7
normal human	7
digit threat	7
well characterized	7
mesothelial cells	7
frequently associated	7
intracellular pathogens	7
low risk	7
test whether	7
inflammatory disorders	7
showed higher	7
microvascular perfusion	7
practice parameters	7
th th	7
potential benefits	7
adaptive response	7
patient ventilator	7
volume controlled	7
weaning failure	7
induced organ	7
uk sepsis	7
tissue samples	7
antigen presenting	7
variables associated	7
derived suppressor	7
many years	7
required mechanical	7
factors may	7
nitrate concentrations	7
obese icu	7
markedly reduced	7
im kardiogenen	7
following hemorrhagic	7
years ago	7
gastric cancer	7
alphaiib beta	7
term outcomes	7
anticoagulant activity	7
endotoxin release	7
ml hr	7
unrestricted policy	7
homologous blood	7
hepatic function	7
prospective clinical	7
help us	7
decreased production	7
andexanet alfa	7
physiological parameters	7
und einem	7
induced apoptosis	7
protected mice	7
medical personnel	7
septic encephalopathy	7
toxic shock	7
verbesserung der	7
steady state	7
care services	7
scrub typhus	7
statistical difference	7
multiple logistic	7
maintain adequate	7
also noted	7
study protocol	7
arterial hypertension	7
microbial products	7
important mediator	7
surgical stress	7
antibacterial therapy	7
auf den	7
negative effects	7
inotrope wirkung	7
sepsis score	7
common practice	7
activated monocytes	7
continuous veno	7
null mice	7
nur bei	7
rna splicing	7
frequent complication	7
source control	7
phase clinical	7
oxygen therapy	7
capillary refi	7
multicenter trial	7
transfusion requirement	7
spontaneously breathing	7
klebsiella spp	7
cytokine secretion	7
last decade	7
alveoloseptal thickening	7
medical treatment	7
cytokines including	7
greater risk	7
es zur	7
evidence based	7
regulatory role	7
descriptive statistics	7
treat patients	7
eu ml	7
dependency unit	7
procoagulant state	7
dysfunktion des	7
der septischen	7
lps lethality	7
fractal dimension	7
consecutively admitted	7
citrate crrt	7
data demonstrate	7
sepsis early	7
data suggests	7
proximal tubular	7
mortality remains	7
im wesentlichen	7
des herzindex	7
different stages	7
high prevalence	7
protects mice	7
lung inflammation	7
intravital microscopy	7
receiving mechanical	7
within minutes	7
receptor signaling	7
levels increase	7
currently used	7
will also	7
cytokine concentrations	7
significantly attenuated	7
high morbidity	7
habp vabp	7
cd ro	7
lymphoid tissue	7
perioperative period	7
rats received	7
sepsis trust	7
bl sccr	7
primary objective	7
bacterial overgrowth	7
inflammatory reactions	7
emergency care	7
age groups	7
ill medical	7
corticotropin stimulation	7
tissue trauma	7
north america	7
negative bacilli	7
i receptor	7
wird durch	7