This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-017838-fbotc479 | The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development? |
| cord-002895-z82e7z2v | Two Distinct Chicken Lines Differ in Their Response to Newcastle Disease Virus? |
| cord-257027-q2y7fewk | Similarly, the possibility of a personalized vaccination strategy( appropriate dose, schedule and even molecular components of the vaccine?) has been suggested, which would be based on individual information, including genome- wide genetic information. |
| cord-278397-u33x4jaw | why so many receptors? |
| cord-004518-jd1wxobz | Raška, Milan title: DNA vaccines: are they still just a powerful tool for the future? |
| cord-216972-migs9rxb | : Is Habit an Empty Construct or an Interesting Case of Goal- directed Automaticity? |
| cord-270469-lle32mha | regulators of ER stress- induced apoptosis ER stress and its regulator X- box- binding protein-1 enhance polyIC- induced innate immune response in dendritic cells, þ3 Endoplasmic reticulum stress in disease pathogenesis Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN- beta induction via X- box binding protein 1 Integration of ER stress and viral nucleotide sensing in DCs: mounting a response commensurate to the threat? |
| cord-269943-g77qe5ml | In Rheumatoid Arthritis( ADIRA)-A randomized, controlled crossover trial indicating effects on disease activity Omega-3 Polyunsaturated Fatty Acids in Critical Illness: Anti- Inflammatory, Proresolving, or Both? |
| cord-305263-fgwf6wy3 | alpha-2a with or without ribavirin for HBeAg- negative chronic hepatitis B Increasing proportion of herpes simplex virus type I as a cause of genital herpes infection in college students Herpes simplex virus encephalitis: new infection or reactivation? |
| cord-285982-1a5u7uux | recent advances in the cytotoxic T- Iymphocyte platform"spotty business DNA vaccines: ready for prime time? |
| cord-276628-uxsjyezo | γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen- specific interleukin-17 response Modulation of inflammation through IL-17 production by γδ T cells: mandatory in the mouse, dispensable in humans? |
| cord-303319-v3iyur78 | The interferon response to intracellular DNA: why so many receptors? |
| cord-003444-dmpoy0b1 | These findings raise the question of can NEI display similar adjuvant activity for vaccines given through other mucosal routes and, possibly non- mucosal vaccines? |
| cord-296886-0bma2749 | ( IHN) virus DNA vaccine in Chinook Oncorhynchus tshawytscha and sockeye O. nerka salmon DNA and RNA- based vaccines: Principles, progress and prospects DNA vaccines- A modern gimmick or a boon to vaccinology? |
| cord-296886-0bma2749 | Progress and challenges Synthetic DNA vaccine strategies against persistent viral infections DNA vaccines: Ready for prime time? |
| cord-032600-lldbjm77 | Is there an optimal formulation and delivery strategy for subunit vaccines? |
| cord-032600-lldbjm77 | So what is my choice for the sixth revolution? |
| cord-319448-gt6uqfrl | The recognition that the disease- to- infection ratio for West Nile virus in endemic areas is very low, led to the successful experimental use of passive antibody therapy with immunoglobulins from asymptomatic Introduces the'damage- response'framework and proposes a new classification for pathogens based on their ability to damage the host as a function of the host response Expands the'damage- response'framework to incorporate the variable of time and proposes that the outcome of the host- microorganism interaction can be reduced to four states that differ in the amount of damage incurred by the host as a function of time What is a pathogen? |
| cord-319448-gt6uqfrl | breath- taking progress Saccharomyces cerevisiae bacteremia A Saccharomyces cerevisiae mutant with increased virulence Parasitealtered behaviour: is the effect of Toxoplasma gondii on Rattus norvegicus specific? |
| cord-266750-41gth6o0 | Can we use interleukin-6( IL-6) blockade for coronavirus disease 2019( COVID-19)-induced cytokine release syndrome( CRS)? |
| cord-266750-41gth6o0 | The coagulative and cardiorespiratory responses to reamed intramedullary nailing of isolated fractures Coagulation, fibrinolysis and cytokine responses to intramedullary nailing of the femur: an experimental study in pigs comparing traditional reaming and reaming with a onestep reamer- irrigator- aspirator system Intramedullary nailing of the femur: current concepts concerning reaming Primary intramedullary femur fixation in multiple trauma patients with associated lung contusiona cause of posttraumatic ARDS? |
| cord-311331-l7dehit8 | Can controversial nanotechnology promise drug delivery? |
| cord-126015-zc7u3g34 | Donor- Recipient Pairs Killer Immunoglobulin- Like Receptor- Ligand Interactions Predict Clinical Outcomes following Unrelated Donor Transplantations Stem cell transplantation as a dynamical system: are clinical outcomes deterministic? |
| cord-126015-zc7u3g34 | The narrowing of the CD8 T cell repertoire in old age Diversity and clonal selection in the human T- cell repertoire Mechanisms shaping the naïve T cell repertoire in the elderly-thymic involution or peripheral homeostatic proliferation? |
| cord-026960-g844u7xg | Given the current input"something is slowing me down bad"as well as the past utterances, the system is expected to identify the most appropriate candidate response, i.e.,"what is the process name with the highest cpu usage?", among all the candidates. |
| cord-026960-g844u7xg | do you have any task manager installed?" |
| cord-023935-o2ffxgnn | In monitoring her response to these interventions, which of the following should NOT be used as a therapeutic endpoint to monitor her progress? |
| cord-023935-o2ffxgnn | There is suffi cient data to justify the use of which of the following adjuvant therapies in pediatric sepsis? |
| cord-023935-o2ffxgnn | Which of the following components of coagulation is increased during sepsis? |
| cord-292983-msuluuuu | 7 Papers of particular interest, published within the period of review, have been highlighted as of special interest of outstanding interest DNA vaccines: ready for prime time? |
| cord-292983-msuluuuu | DNA vaccines- how far from clinical use? |
| cord-307202-iz1bo218 | Is asthma a nervous disease? |
| cord-018937-5yo4rfml | Mostly dead: can science help with disaster triage? |
| cord-018937-5yo4rfml | What is an incident action plan? |
| cord-274027-ovdhnajp | With previous experiences, would the COVID-19 outbreak further segregate the gender inequities in impacts and response strategies? |
| cord-278938-bmahwxbn | Our Response to COVID-19 as Endocrinologists and Diabetologists COVID-19 and treatment with NSAIDs and corticosteroids: should we be limiting their use in the clinical setting? |
| cord-288868-qfdxri93 | In addition, the isolated case in December 2003 was caused by a virus with highest sequence homology to palm civets West Nile virus: where are we now? |
| cord-288868-qfdxri93 | Pandemic influenza: a zoonosis? |
| cord-271250-ywb26cq6 | The adjuvant LT- K63 can restore delayed maturation of follicular dendritic cells and poor persistence of both protein- and polysaccharide- specific antibody- secreting cells in neonatal mice Adjuvants enhancing cross- presentation by dendritic cells: the key to more effective vaccines? |
| cord-271250-ywb26cq6 | a meta- analysis Immunobiology of HPV and HPV vaccines Comparative immunogenicity and safety of human papillomavirus( HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine administered according to 2-and 3-dose schedules in girls aged 9- 14 years: results to month 12 from a randomized trial Adjuvants in tuberculosis vaccine development TB vaccine development and the end tb strategy: importance and current status NOD2 and toll- like receptors are nonredundant recognition systems of mycobacterium tuberculosis Multi- stage subunit vaccines against mycobacterium tuberculosis: an alternative to the BCG vaccine or a BCG- prime boost? |
| cord-271250-ywb26cq6 | opportunities and challenges What role does the route of immunization play in the generation of protective immunity against mucosal pathogens? |
| cord-030999-27wennun | Should we be devoting extensive attention to the details of T- cell immunity if the data suggest that neutralizing antibody titre is itself a candidate correlate of protection? |
| cord-030999-27wennun | Which cells have produced the response and to what specific viral stimulus? |
| cord-030999-27wennun | infection, immunology research has been placed in the spotlight, with intense curiosity and scrutiny about many specific aspects of the immune response to this viral infection: when does immunity develop, what are the correlates of protection, what is the temporal relationship between immunity and infectivity, do all develop protective immunity and can reinfection occur, what part is played by immunopathology in pathological damage to the lungs and other organs? |
| cord-314104-dkm8396y | For example, if this person had recently returned from a country with an ongoing Ebola outbreak, would the existing triage system be sufficient to identify, assess, and rapidly contain a possible Ebola case? |
| cord-018839-yfaji9cv | DHS( 2013) Threat and hazard identification and risk assessment guide: comprehensive preparedness Guide Again and again: is a disaster what we call a"disaster? |
| cord-018839-yfaji9cv | Normal accidents: living with high risk technologies What is a disaster? |
| cord-322913-sq9mq6f1 | Immunosenescence and inflamm- aging as two sides of the same coin: friends or foes? |
| cord-287396-18p171nr | In a study by Flori and co- workers, the Qiagen- NRSP8 array was extended by adding probes for Pseudorabies Virus RNAs as well as probes for transcripts from the porcine Major Histocompatibility Complex, also called the Swine Leukocyte Antigen( SLA) complex, referred to as the Qiagen? |
| cord-287396-18p171nr | Whereas RNA- seq will sequence all transcripts containing poly- A? |
| cord-284845-on97zu6w | Distinct immune response in two MERS- CoV- infected patients: can we go from bench to bedside? |
| cord-284845-on97zu6w | the major drug targets of the twenty- first century? |
| cord-311823-85wj08gr | Does the converse hold true for a virus such as HCV, which typically establishes a persistent infection characterized by mild( or slowly progressing) disease? |
| cord-311823-85wj08gr | How then can greater benefits be gained from using functional genomics to study virus- host interactions? |
| cord-266204-ipa017wz | * 03-bound measles virus peptides by 2D- liquid chromatography tandem mass spectrometry Are cases of mumps in vaccinated patients attributable to mismatches in both vaccine T- cell and B- cell epitopes?: |
| cord-266204-ipa017wz | : how much can the adaptive immune system adapt? |
| cord-266204-ipa017wz | Is science leading us toward a new path of directed vaccine development and discovery? |
| cord-266204-ipa017wz | The immunogenetics of smallpox vaccination Genetic basis for adverse events after smallpox vaccination Identification of fever and vaccine- associated gene interaction networks using ontology- based literature mining Common variants associated with general and MMR vaccine- related febrile seizures The clinician's guide to the anti- vaccinationists'galaxy Trends affecting the future of vaccine development and delivery: the role of demographics, regulatory science, the anti- vaccine and consumer culture and vaccinomics Understanding those who do not understand: a brief review of the anti- vaccine movement Accelerated mass production of influenza virus seed stocks in HEK-293 suspension cell cultures by reverse genetics Cell culture- based influenza vaccines: A necessary and indispensable investment for the future Ebola virus vaccines: where do we stand? |
| cord-266204-ipa017wz | We have asked the question, as have other scientists,''does it make sense in the 21st century to give the same vaccine, dose, and at the same frequency to everyone, regardless of age, weight, gender, race, genotype, and medical condition?" |
| cord-263315-g7os15m1 | Can Anopheles Gambiae Be Infected with Wolbachia Pipientis? |
| cord-021424-kocwsyi7 | : How close are we to generalised use in the infectious disease clinic? |
| cord-021424-kocwsyi7 | A polymorphism in the toll- like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy Microarray analysis of pathogens and their interaction with hosts Virus infection and the interferon response: A global view through functional genomics Unlocking the mysteries of virus- host interactions: Does functional genomics hold the key? |
| cord-021424-kocwsyi7 | Can genomic approaches be used to determine the outcome of infection? |
| cord-021424-kocwsyi7 | How many diseases does it take to map a gene with SNPs? |
| cord-021424-kocwsyi7 | What can be applied to clinical medicine from these studies? |
| cord-289961-7q2wkwrf | What controls the melting properties of DNA- linked gold nanoparticle assemblies? |
| cord-311811-nrodyagi | Or, were they among the"worried well"? |
| cord-330583-ltkpt80u | Focus on the Marine Environmental Damage by Oil Pollution in South Korea and Japan Management of Emergent Networks during Disasters- A Meta synthesis Relationship between Effectiveness of Disaster Management and Cooperative Factors of Agencies in Disaster Management MERS Isolation Patient- A Public Enemy? |
| cord-330583-ltkpt80u | How did MERS Outbreak Become a Political Matter?: |
| cord-324143-ztj6o4ob | How satisfied are you with your ability to perform your daily living activities?). |
| cord-324143-ztj6o4ob | Advance online publication Are people excessively pessimistic about the risk of coronavirus infection? |
| cord-298525-hhcfrjrn | 123I- DaTSCAN imaging in Parkinson's disease: A comparison study Is videopupillography useful in the diagnosis of Alzheimer's disease? |
| cord-298525-hhcfrjrn | Why rods and cones? |
| cord-307229-wjx90xki | ( ACE2) is a key modulator of the renin angiotensin system in health and disease Expression of the SARS- CoV-2 cell receptor gene ACE2 in a wide variety of human tissues COVID-19 and chronological aging: senolytics and other anti- aging drugs for the treatment or prevention of corona virus infection? |
| cord-307229-wjx90xki | The ACE-2 in COVID-19: foe or Friend? |
| cord-016713-pw4f8asc | ( review) Pathogen recognition and development of particulate vaccines: does size matter? |
| cord-016713-pw4f8asc | : what are the benefits for the elderly? |
| cord-016713-pw4f8asc | I( IGF- I) Immunogenicity in mice of a cationic microparticle- adsorbed plasmid DNA encoding Japanese encephalitis virus envelope protein Vaccine potential of cytosolic proteins loaded fibrin microspheres of Cryptococcus neoformans in BALB/ c mice Plasmid DNA loaded chitosan nanoparticles for nasal mucosal immunization against hepatitis B Comparing the effect of IL-12 genetic adjuvant and alum non- genetic adjuvant on the efficiency of the cocktail DNA vaccine containing plasmids encoding SAG-1 and ROP-2 of Toxoplasma gondii Nasal immunization with plasmid DNA encoding P6 protein and immunostimulatory complexes elicits nontypeable Haemophilus influenzaespecific long- term mucosal immune responses in the nasopharynx Nanoparticles as carriers for nasal vaccine delivery DNA vaccines: ready for prime time? |
| cord-016713-pw4f8asc | basic studies and applications Immune responses against a new HIV-1 p24-gp41/ pCAGGS- IL-12 DNA vaccine in Balb/ c mice Enhancement of cellular immune response to a prostate cancer DNA vaccine by intradermal electroporation Live attenuated AIDS viruses as vaccines: promise or peril? |
| cord-016713-pw4f8asc | human immunodeficiency virus type 1 Anionic PAMAM dendrimers rapidly cross adult rat intestine in vitro: a potential oral delivery system? |
| cord-318599-drvjr7gq | ( COVID-19) Time will tell? |
| cord-318599-drvjr7gq | An empirical analysis in German food retail logistics Can first- mover and early- mover advantages be sustained in an industry with low barriers to entry/ imitation? |
| cord-318599-drvjr7gq | Innovative"bring- service- near- your- home"operations under Corona- virus( COVID-19/ SARS- CoV-2) outbreak: Can logistics become the messiah? |
| cord-318599-drvjr7gq | Why are Britain's borders STILL open? |
| cord-318272-spt0oea0 | CAF01, promotes long- lived Mycobacterium tuberculosis- specific T- cell responses in human A triple co- culture model of the human respiratory tract to study immune- modulatory effects of liposomes and virosomes The novel immunogenic chimeric peptide vaccine to elicit potent cellular and mucosal immune responses against HTLV-1 Immune responses induced by nano- self- assembled lipid adjuvants based on a monomycoloyl glycerol analogue after vaccination with the Chlamydia trachomatis major outer membrane protein Cubosomes: the next generation of smart lipid nanoparticles? |
| cord-318272-spt0oea0 | In vivo gold nanoparticle delivery of peptide vaccine induces anti- tumor immune response in prophylactic and therapeutic tumor models Gold nanoparticles as a vaccine platform: influence of size and shape on immunological responses in vitro and in vivo Multicopy multivalent'glycopolymer- stabilized gold nanoparticles as potential synthetic cancer vaccines Synthesis of a novel kind of carbon nanoparticle with large mesopores and macropores and its application as an oral vaccine adjuvant Single- walled carbon nanotubes deliver peptide antigen into dendritic cells and enhance IgG responses to tumor- associated antigens Immunisation of mice by hollow mesoporous silica nanoparticles as carriers of porcine circovirus type 2 ORF2 protein Silica vesicle nanovaccine formulations stimulate long- term immune responses to the bovine viral diarrhoea virus E2 protein Lipopeptide- coated iron oxide nanoparticles as potential glycoconjugate- based synthetic anticancer vaccines A visible codelivery nanovaccine of antigen and adjuvant with self- carrier for cancer immunotherapy Effect of preexisting neutralizing antibodies on the anti- tumor immune response induced by chimeric human papillomavirus virus- like particle vaccines Room temperature stable PSPA- based nanovaccine induces protective immunity Reversal of autoimmunity by boosting memory- like autoregulatory T cells Peptide- MHC- based nanovaccines for the treatment of autoimmunity: a"one size fits all"approach? |
| cord-021175-0ikkl3hk | According to need? |
| cord-021175-0ikkl3hk | Data hubris? |
| cord-021175-0ikkl3hk | New media, new civics? |
| cord-021175-0ikkl3hk | So what is next? |
| cord-021175-0ikkl3hk | What will it take to move risk communication into the twenty- first century? |
| cord-021175-0ikkl3hk | what role for ICT and mobile technologies? |
| cord-018475-h8qwxdtn | Given this state of affairs can we anticipate the responses of our citizenry to bioterrorism and if so how can government and civil society prepare and increase societal resilience to such attacks? |
| cord-018475-h8qwxdtn | Innoculating resilience to terrorism: acute and posttraumatic stress responses in US military, foreign& civilian services serving overseas after Toxic turmoil: psychological and societal consequences of ecological disasters Soldiers for god: a study of the suicide terrorists in the Moscow hostage taking siege Unpublished interviews from the Madrid training bombings Civil society's response to mass terrorism: building resilience Psycho- social and physical outcomes of technological disaster: information as a traumatic stressor Unpublished Beslan interviews Universal responses to abortion? |
| cord-018475-h8qwxdtn | poisoning or epidemic hysteria in kosovo? |
| cord-328935-mn8r972x | First, why is the systemic response to the LPG/ protein complex skewed toward IgG1( a Th2 response in cattle) and not IgG2( a Th1 response)? |
| cord-328935-mn8r972x | Second, are IgG or IgA antibodies to the LPG- containing antigen most protective and how can that Ig isotype be enriched to enhance protection? |
| cord-286072-kgpvdb42 | : What Do They All Do? |
| cord-286072-kgpvdb42 | How the SARS coronavirus causes disease: host or organism? |
| cord-257722-7rmzaau4 | HP55/ PLGA nanoparticles promote immune protection Lectin anchored PLGA nanoparticles for oral mucosal immunization against hepatitis B Targeted delivery of GP5 antigen of PRRSV to M cells enhances the antigen- specific systemic and mucosal immune responses Targeting nanoparticles to M cells with non- peptidic ligands for oral vaccination Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide- coupled chitosan Targeted delivery of chitosan nanoparticles to Peyer's patch using M cell- homing peptide selected by phage display technique Attuning hydroxypropyl methylcellulose phthalate to oral delivery vehicle for effective and selective delivery of protein vaccine in ileum Combinatorial approach of antigen delivery using M cell- homing peptide and mucoadhesive vehicle to enhance the efficacy of oral vaccine Can bioadhesive nanoparticles allow for more effective particle uptake from the small intestine? |
| cord-257722-7rmzaau4 | Nanogel- based nasal ghrelin vaccine prevents obesity Intranasal drug delivery: how, why and what for? |
| cord-257722-7rmzaau4 | Nanoparticulate systems for nasal delivery of drugs: a real improvement over simple systems? |
| cord-272512-gevrlcvy | Does this confirm trafficking of antigen- specific memory cells following exposure of the nasopharynx to transgenic alfalfa or does this suggest that vaccine antigen survived rumination and sensitized GALT by transport across the intestinal epithelium? |
| cord-272512-gevrlcvy | Is the edible format the future for veterinary vaccines in ruminanting animals? |
| cord-272512-gevrlcvy | Why vaccinate mucosally? |
| cord-354790-xx6imhzb | Antibody- mediated immunomodulation: a strategy to improve host responses against microbial antigens Antiviral monoclonal antibodies: can they be more than simple neutralizing agents? |
| cord-354790-xx6imhzb | Intravenous immunoglobulin therapy: how does IgG modulate the immune system? |
| cord-354790-xx6imhzb | Which antibody functions are important for an HIV vaccine? |
| cord-355541-5sctqkwr | How, when and where is the efficacy of the different vaccines to be evaluated? |
| cord-355541-5sctqkwr | Neutralizing antibody- independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations HIV-1 neutralizing antibodies: how full is the bottle? |
| cord-355541-5sctqkwr | WHO The global alliance for vaccines and immunization: a millennial challenge Accelerating the development and future availability of HIV-1 vaccines: why, when, where, and how? |
| cord-009836-7o6htufh | -the war being lost What can we learn about human immunodeficiency virus infection from a study of lymphocytic choriomeningitis virus? |
| cord-009836-7o6htufh | : how important are they in viral evasion of immune clearance in vivo? |
| cord-009836-7o6htufh | Chisari FV Hepatitis B virus( HBV) sequence variation in cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection Chisari FV Is antigenic variability a strategy adopted by hepatitits B virus to escape cytotoxic T- lymphocyte surveillance? |
| cord-009836-7o6htufh | This patient clearly bad the capacity to make CTL responses to a broad range of epitopes in HIV; why then was his initial response so highly foctised on a single epitope? |
| cord-009836-7o6htufh | Why ca n't cytotoxic T cells handle HIV? |
| cord-009836-7o6htufh | as the host immune response is aiso adaptive, can it in turn evoive in response to the emergence of escape viral variants? |
| cord-022076-zpn2h9mt | In 1984, did restaurant patrons in Wasco County, Ore., have any idea, as they selected food from salad bars, that they would soon be evaluated in hospitals for profuse, watery diarrhea from intentional food contamination by a religious cult? |
| cord-022076-zpn2h9mt | In March 2003, did the 11 Toronto healthcare workers who were caring for patients with respiratory symptoms know they would soon become infected with severe acute respiratory syndrome( SARS)? |
| cord-022076-zpn2h9mt | On April 19, 1995, did the emergency department staff arriving for the day shift at 13 Oklahoma City hospitals know that a former soldier was driving a rented van filled with 4000 pounds of ammonium nitrate toward the Murrah Federal Building and that they would soon be faced with 324 bombing victims? |
| cord-022076-zpn2h9mt | The Station Nightclub fire and disaster preparedness in Rhode Island Mass decontamination: why re- invent the wheel? |
| cord-022076-zpn2h9mt | When the first rain began to fall in Houston, Texas, in June 2001, did hospital staff know they would soon be providing care for hundreds of patients without electrical power or running water in flooded hospital buildings? |
| cord-324788-echu0zmf | : how much do we know? |
| cord-324788-echu0zmf | A review of potential mechanisms Immune mechanisms of pathogenetic synergy in concurrent bovine pulmonary infection with Haemophilus somnus and bovine respiratory syncytial virus Proteomic characterization of the interstitial fl uid perfusing the breast tumor microenvironment: a novel resource for biomarker and therapeutic target discovery Unlocking the mysteries of virus- host interactions: does functional genomics hold the key? |
| cord-324788-echu0zmf | and what's next? |
| cord-293893-ibca88xu | Or is the PERDFNPS method suitable for the decision problem? |
| cord-293893-ibca88xu | Selecting the relevant decision methods, data- dependent or structuredependent? |
| cord-293893-ibca88xu | Therefore, in the implementation stage, the decision makers must firstly determine what type of decision problem it is: Is there enough historical data for building a model for this event? |
| cord-293893-ibca88xu | the sentiment triggered by a periodic heated topic with enough investigable historical data or by an unconventional heated topic? |
| cord-320431-0877trhh | : how might its expression define plasma cell development? |
| cord-320431-0877trhh | Bronchial epithelial cells: The key effector cells in the pathogenesis of chronic obstructive pulmonary disease? |
| cord-320431-0877trhh | not proinflammatory cytokines Role of double- stranded RNA pattern recognition receptors in rhinovirus- induced airway epithelial cell responses Dynamic cross talk model of the epithelial innate immune response to double- stranded RNA stimulation: coordinated dynamics emerging from cell- level noise Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double- stranded RNA responsiveness in airway epithelial cells Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG- I- dependent antiviral responses in human lung epithelial cells Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection Activation of Toll- like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2 RAGE and TLRs: relatives, friends or neighbours? |
| cord-339694-sp212tai | A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease Nidovirales: a new order comprising Coronaviridae and Arteriviridae Induction of alpha interferon by transmissible gastroenteritis coronavirus: role of transmembrane glycoprotein E1 Murine intestinal mucins inhibit rotavirus infection Cross- talk between probiotic bacteria and the host immune system Critical role of IL-17RA in immunopathology of influenza infection Probiotics and prebiotics: effects on diarrhea Construction and characterization of Lactobacillus pentosus expressing the D antigenic site of the spike protein of Transmissible gastroenteritis virus Molecular cloning, expression, and in silico structural analysis of guinea pig IL-17 Probiotics enhance the recovery of gut atrophy in experimental malnutrition Genomes of microbes inhabiting the body offer clues to human health and disease Polarizing T and B cell responses by APC- targeted subunit vaccines Gnotobiotic piglets develop thrombotic microangiopathy after oral infection with enterohemorrhagic Escherichia coli Effect of intranasal administration of Lactobacillus casei Shirota on influenza virus infection of upper respiratory tract in mice Probiotics: a role in the treatment of intestinal infection and inflammation? |
| cord-339694-sp212tai | A transmissible gastroenteritis coronavirus nucleoprotein epitope elicits T helper cells that collaborate in the in vitro antibody synthesis to the three major structural viral proteins Cooperation between transmissible gastroenteritis coronavirus( TGEV) structural proteins in the in vitro induction of virus- specific antibodies Bioecological and nutritional control of disease: prebiotics, probiotics and synbiotics Kinetics of the in vitro antibody response to transmissible gastroenteritis( TGE) virus from pig mesenteric lymph node cells, using the ELISASPOT and ELISA tests Intestinal microflora and homeostasis of the mucosal immune response: implications for probiotic bacteria? |
| cord-017817-ztp7w9yh | Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes? |
| cord-017817-ztp7w9yh | Endocytosis and autophagy: exploitation or cooperation? |
| cord-017817-ztp7w9yh | How can this be? |
| cord-017817-ztp7w9yh | Such"ROS- induced ROS release"might permit small ROS signals generated by mitochondria to activate ROS signalling throughout the cell, thereby avoiding mitochondrial damage that might arise if the entire cellular oxidant signal originated from that organelle[ 83]( or even leading to excessive ROS production?). |
| cord-017817-ztp7w9yh | What's the damage? |
| cord-017817-ztp7w9yh | an essential component of universal oxygen sensing machinery? |
| cord-273479-kira7mz6 | Behavioral effects of cytokines Cytokine- induced sickness behaviour: mechanisms and implications Cytokine- induced sickness behavior: where do we stand? |
| cord-273479-kira7mz6 | Do you have to work very intensively?'') were administered, |
| cord-273479-kira7mz6 | Eight items( e.g.,''Do you have enough money for the kind of clothing you and your family should have?'') were presented, with response options ranging from 1= |
| cord-309161-ceahghs1 | A recipe for accelerated cellular aging? |
| cord-309161-ceahghs1 | Hormones Can Childhood Adversity Affect Telomeres of the Next Generation? |
| cord-309161-ceahghs1 | How can we best translate hormetic interventions to humans? |
| cord-309161-ceahghs1 | Ten years of life: Is it a matter of choice? |
| cord-309161-ceahghs1 | The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging? |
| cord-309161-ceahghs1 | The geroscience agenda: What does stress have to do with it? |
| cord-033714-rz5unqaz | Can new tools keep them afloat? |
| cord-033714-rz5unqaz | Domestic violence on the rise, are men putting more pressure on women? |
| cord-033714-rz5unqaz | Governing Social Isolation in São Paulo, Brazil, During the COVID-19 Pandemic Aerial footage shows miles- long queue for food aid in South Africa Density is New York City's big'enemy'in the coronavirus fight Covid-19 and the Hrishipara Diarists: was April the cruellest month? |
| cord-033714-rz5unqaz | How Does Covid-19 Affect Urban Slums? |
| cord-033714-rz5unqaz | How do we prevent a response driven by environmental health imperatives that is fundamentally hostile to informal dwellers, condemning them because of their poverty? |
| cord-033714-rz5unqaz | The Transformative Role of City- Community Partnerships in the Fight against Ebola and Beyond in Greater Monrovia Covid-19: Civil society bodies warn against de- densification of informal settlements How are Peru's street vendors facing COVID-19? |
| cord-033714-rz5unqaz | What then is the potential to see the shock of COVID-19 as an opportunity? |
| cord-015147-h0o0yqv8 | Here we report on the development of the PGE2 mimetic combination therapy( DP-837953) that inhibits basal and LPS/ TLR4 induced TNF-?, IL-1ß, and MMP-1, 8, 9, 13 in human and murine synovial membranes and peripheral macrophages. |
| cord-015147-h0o0yqv8 | In a murine model of chronic synovitis( dorsal skin air pouch), DP837953 dramatically inhibited IL-1ß, TNF-?, MIP2, MCP-2 and IL-8 expression, delayed the profile of leukocyte/ neutrophil extravasation and reduced exudate volume. |
| cord-015147-h0o0yqv8 | In addition, TNF-?, IL-1ß, MMP-8 and to a lesser extent MMP-9 expression/ synthesis levels were strongly suppressed as judged by RT- PCR and ELISA measurements |
| cord-015147-h0o0yqv8 | Most of the recent studies have focused on challenge- induced expression of antimicrobial peptides and have addressed the following questions:( 1) which genes are upregulated during various types of bacterial, fungal or viral infections and what are their functions? |
| cord-021980-ddau5fu3 | How can an event resulting in the loss of seven people be placed in the same category as one that kills hundreds of thousands? |
| cord-021980-ddau5fu3 | However, what about the destruction of the space shuttle Columbia on reentry? |
| cord-021980-ddau5fu3 | What exactly is disaster medicine? |
| cord-021980-ddau5fu3 | What is it about the sheer number of dead and injured that allows the event to be called a disaster? |
| cord-021980-ddau5fu3 | What is it? |
| cord-021980-ddau5fu3 | Who defines it, and by what criteria? |
| cord-303674-0xo2fiop | + bacteria by M cells initiates mucosal immune response Green therapeutic biocapsules: using plant cells to orally deliver biopharmaceuticals Transgenic plants: a 5-year update on oral antipathogen vaccine development Plant- based vaccines against viruses Preclinical and clinical development of plant- made virus- like particle vaccine against avian H5N1 influenza Food- grade organisms as vaccine biofactories and oral delivery vehicles Plant- made oral vaccines against human infectious diseases- are we there yet? |
| cord-303674-0xo2fiop | -lymphocytes, dendritic cells or keratinocytes? |
| cord-303674-0xo2fiop | Chimeric antigen receptor( CAR)-redirected T cells: is there a place for them in infectious diseases? |
| cord-303674-0xo2fiop | Intradermal vaccine delivery: will new delivery systems transform vaccine administration? |
| cord-303674-0xo2fiop | Need of cost- effective vaccines in developing countries: what plant biotechnology can offer? |
| cord-303674-0xo2fiop | The increasing value of plant- made proteins Plant- produced vaccines: promise and reality Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta- TC6 cells Disease prevention: an opportunity to expand edible plant- based vaccines? |
| cord-280605-2i4gk7et | A SYSDIET Sub- Study Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? |
| cord-280605-2i4gk7et | Do You Remember Mitochondria? |
| cord-280605-2i4gk7et | What is a healthy Nordic diet? |
| cord-280605-2i4gk7et | attenuates atherosclerotic plaque formation in diet and inflammation- induced atherogenesis Human CNS immune senescence and neurodegeneration Microglial senescence: does the brain's immune system have an expiration date? |
| cord-024571-vlklgd3x | How are intergovernmental relations mixed with intersectoral relations in ERNs? |
| cord-024571-vlklgd3x | In what way were distinctive communities divided in the ERN? |
| cord-024571-vlklgd3x | Similarly, other clique- like approaches( n- cliques and k- cores) demand an answer to the question:"What is the n- or k-? |
| cord-024571-vlklgd3x | Thus, two questions remain: which algorithm do we choose and how do we know whether the community structure is robust( Karrer, Levina,& Newman, 2008)? |
| cord-024571-vlklgd3x | When are networks truly modular? |
| cord-024571-vlklgd3x | and( 2) How did the interorganizational relations relate to the internal characteristics of the communities? |
| cord-344985-3mu9rrql | : Are we there yet? |
| cord-344985-3mu9rrql | Alliance Manchester Business School Is the response over? |
| cord-344985-3mu9rrql | As with fire, it is not a question of"if?" |
| cord-344985-3mu9rrql | How can society recover from covid-19? |
| cord-344985-3mu9rrql | The Guardian The Sendai Framework for Disaster Risk Reduction and its indicators- where does health fit in? |
| cord-344985-3mu9rrql | but"when?". |
| cord-022252-9yiuuye3 | ( An era of new'magic bullets'?) |
| cord-022252-9yiuuye3 | Could it be that host responses to LPS are, like the complement or the clotting systems, useful in moderation but harmful in excess? |
| cord-022252-9yiuuye3 | Cytolytic pore- forming proteins and peptides: is there a common structural motif? |
| cord-022252-9yiuuye3 | How does CT work? |
| cord-022252-9yiuuye3 | What is the role played by Shiga toxin? |
| cord-339935-tguhrqvz | Co- production during and after the Covid-19 pandemic: will it last? |
| cord-339935-tguhrqvz | European Coronationalism? |
| cord-339935-tguhrqvz | How Can Local Governments Address Pandemic Inequities? |
| cord-339935-tguhrqvz | Steen and Brandsen( 2020) note how the pandemic necessitated this kind of coordinated response, and they pose an important question that should guide research for years to come: will it last? |
| cord-339935-tguhrqvz | What drives successful administrative performance during crises? |
| cord-339935-tguhrqvz | Who Are the Present and Future Noncompliers? |
| cord-290264-pv7ijdnx | Are people used to video conferencing? |
| cord-290264-pv7ijdnx | Are the necessary technology toolsets already in their hands? |
| cord-290264-pv7ijdnx | Do you have backup, and can you work remotely? |
| cord-290264-pv7ijdnx | Does your organization already have an experienced virtual meetings culture? |
| cord-290264-pv7ijdnx | Have the newest, least experienced, and/or most struggling colleagues been given what they need to do their part? |
| cord-290264-pv7ijdnx | What about vendors, contractors, and suppliers that you depend on- is there adequate redundancy in your supply chain? |
| cord-290264-pv7ijdnx | What happens if your child's school closes and you are forced to quarantine at home with them? |
| cord-022888-dnsdg04n | /CRTAM on gd T cells? |
| cord-022888-dnsdg04n | As the results show, could there not be a direct relationship between the HLA system and the development of SA or TBC, or in contrast, was the first patient missdiagnosed of TBC being a good prognosis SA? |
| cord-022888-dnsdg04n | Could Carabin play a role of negative regulator of B cell function? |
| cord-022888-dnsdg04n | How is the IGSF4-CRTAM axis regulated in T cells? |
| cord-022888-dnsdg04n | a one- year prospective birth cohort study PC09/16 TO WHAT EXTENT T- SPOT.TB COULD BE USED IN THE DIAGNOSIS OF TUBERCULOSIS IN CHILDREN EXPOSED TO TB INFECTION? |
| cord-281437-cb3u1s7s | A seminal study that shows that ring vaccination could be used in the midst of a devastating Ebola epidemic and, furthermore, that innovation research can be conducted in an epidemic, trial designs can be adapted without compromising scientific integrity and that Ebola can be prevented through vaccination Ethical rationale for the Ebola"ring vaccination"trial design Ebola vaccination in the Democratic Republic of the Congo Insights from clinical research completed during the West Africa Ebola virus disease epidemic Gone or forgotten? |
| cord-281437-cb3u1s7s | A theory of the epidemiology of population change Large Ebola outbreaks new normal, says WHO Applied epidemiology and public health: are we training the future generations appropriately? |
| cord-281437-cb3u1s7s | From Knowledge to Action Anthropology in public health emergencies: what is anthropology good for? |
| cord-281437-cb3u1s7s | p263 Farr's law applied to AIDS projections Epidemiology- is it time to call it a day? |
| cord-281437-cb3u1s7s | the question to the answer? |
| cord-281437-cb3u1s7s | when will we learn from Sierra Leone? |
| cord-023143-fcno330z | *? |
| cord-023143-fcno330z | , Cara Wilsont, Kelledy Mansons, Michael Wyands, Bruce Walker?, Ronald C. Desrosiers |
| cord-023143-fcno330z | However, productive virus replication is minimized by antiviral CD8 T cells which suppress( kill?) |
| cord-023143-fcno330z | PrP genes were used to demonstrate that the"specie9 bank?' |
| cord-023143-fcno330z | The interferons( IFNs) a n? a family of cytokines whose functions include the protection of cells against viral infection. |
| cord-023143-fcno330z | Thes? |
| cord-023143-fcno330z | ofthe influenza HA protein from this second promoter in baby hamster kidney( BHK) cells was approximately 50?? |
| cord-023143-fcno330z | ofthe influenza HA protein from this second promoter in baby hamster kidney( BHK) cells was approximately 50?? |
| cord-264159-e9071tyv | Apart from basic science discovery, how do these insights affect clinical practice in infectious disease? |
| cord-264159-e9071tyv | Do they share similar features that might be reasons for their susceptibility of infection? |
| cord-264159-e9071tyv | Furthermore, how are host cells'phenotypes influenced by infection individually and temporally? |
| cord-264159-e9071tyv | How do the states of infected cells affect pathogen replication and infection outcome? |
| cord-264159-e9071tyv | How does this preference arise? |
| cord-264159-e9071tyv | Why are certain people more susceptible to infections? |
| cord-264159-e9071tyv | Why are some infected individuals asymptomatic or display only mild symptoms? |
| cord-264159-e9071tyv | Why are there differences in terms of disease progression and outcomes among patients? |
| cord-015910-d9gxew91 | --how strong is the association? |
| cord-015910-d9gxew91 | A fundamental question is which precedes the other- the general increase in inflammation or the development of diseases with overt and covert inflammatory bases? |
| cord-015910-d9gxew91 | Are these phenomena an unfortunate side effect of maturity, or is there a common mechanism that determines the appearance of these diseases patterns in the elderly.'? |
| cord-015910-d9gxew91 | Could glutamine be exerting an anti- inflammatory influence via an effect on GSH that enhances immune function? |
| cord-015910-d9gxew91 | Do the general findings from this type of study also apply to modulation of low- grade chronic inflammation, such as has been observed in the elderly and obese? |
| cord-015910-d9gxew91 | Does N- acetyl cysteine inflkuence cytokine response during early human septic shock? |
| cord-015910-d9gxew91 | Free RadicalBiology andMedicine Do men and women follow different trajectories to reach extreme longevity? |
| cord-015910-d9gxew91 | Genetically determined? |
| cord-015910-d9gxew91 | Involvement of IkappaB- alpha stabilisation Are differences in interleukin 10 production associated with joint damage? |
| cord-015910-d9gxew91 | Is major histocompatibility complex polymorphism relevant to the control of human longevity? |
| cord-015910-d9gxew91 | Is there, therefore, a link between this phenomenon and increased levels of inflammation? |
| cord-015910-d9gxew91 | The roles of Nramp 1 and Tnfo~ genes in nitric oxide production and their effect on the growth of Salmonella typhimurium in macrophages from Nrampl congenic and tumor necrosis factor- alpha-/-mice Polymorphism of the human TNF- cz promoter-- random variation or functional diversity? |
| cord-015910-d9gxew91 | What mechanisms could result in this divergent effect? |
| cord-015910-d9gxew91 | Why does tissue GSH content have differing effects on immune cell populations depending on whether or not an inflammatory response is occurring? |
| cord-031885-by4cujyy | : What are they? |
| cord-031885-by4cujyy | Finally, how does digital technology adoption change a firm's value creation paths? |
| cord-031885-by4cujyy | Finally, what is the underlying mechanism through which digitalization impacts crisis response strategies? |
| cord-031885-by4cujyy | First, how do different public crises( natural vs. social) reshape the business environment? |
| cord-031885-by4cujyy | First, is digitalization a new source of competitive advantages for firms? |
| cord-031885-by4cujyy | In search of the drivers of high growth in manufacturing SMEs Are you ignoring trends that could shake up your business? |
| cord-031885-by4cujyy | In the face of the pandemic, your firm has taken the following strategies to protect employees'rights: Five myths about digital transformation Digital affordances, spatial affordances, and the genesis of entrepreneurial ecosystems Masters of disasters? |
| cord-031885-by4cujyy | Second, how should firms'digital business strategies be designed? |
| cord-031885-by4cujyy | Second, what is the nature of firms'strategic decision- making in crisis environments characterized by sudden and violent environmental changes? |
| cord-031885-by4cujyy | The digital transformation of innovation and entrepreneurship: Progress, challenges and key themes Adapt, move or surrender? |
| cord-031885-by4cujyy | Then comes the question: What kind of firms are more likely to be able to dynamically respond to public crises? |
| cord-031885-by4cujyy | Third, how does a digital business strategy guide a firm's adoption of digital technologies? |
| cord-031885-by4cujyy | Third, what are the similarities and differences between short- term emergency response strategies and long- term strategic response strategies? |
| cord-031885-by4cujyy | Well known or well liked? |
| cord-031885-by4cujyy | What is a pivot? |
| cord-023055-ntbvmssh | -%~~ specific? |
| cord-023055-ntbvmssh | D61 and D62 are 9 and 13 bp long, are frequently recombine as D,1/ D62? and reveal exonucleolytic trimning with extensive"N"segment addition. |
| cord-023055-ntbvmssh | In support of this possibility, thymectomized&+( a x b)F1 chimeras given strain J? marrow cells and a strain thymus graft( irradiated) show no detectable tolerance to host- type strain b determinants: the strain& CD4+ cells differentiating in these chimeras give strong MLR to strain b and do not show deletion of v 11+ cells. |
| cord-023055-ntbvmssh | The efect of these TCR differences on recognition was assessed using a pane? |
| cord-023055-ntbvmssh | The existence of"primed"T cells in phenotypically tolerant animals raises the possibility that precocious activation of TR1( by neonatal exposure to tolerogen?) suppresses the later emergence of T,,, which would be expected to contain the cells responsible for graft rejection. |
| cord-023055-ntbvmssh | The increase peaked at 2 min and returned almost to baseline by 10 mi?. |
| cord-023055-ntbvmssh | Us& this tecfinolosy we have begun to characterize the irmnUne reqonse to individual peptide antigens.? |
| cord-023055-ntbvmssh | Us& this& logy we have begun to characterize the innume response to individual Peptide antigens.? |
| cord-023055-ntbvmssh | We have extended these exper- to inta? |
| cord-023055-ntbvmssh | We reasoned that given the potential for direct peptide/ class?'&$% ation observed in vifro, OVA2s,-2ra may induce CTL after in vivo priming. |
| cord-023055-ntbvmssh | c a l l y autoreactive T cell:? |
| cord-023055-ntbvmssh | e human nutoinimiine tlisrases maintdin:? |
| cord-285778-80baxwgc | The Race between Infection and Immunity: How do Pathogens Set the Pace?by Davenport, M.P., Belz, G. T. and Ribeiro, R.M.,( 2009) |
| cord-285778-80baxwgc | 1) Can you define these terms? |
| cord-285778-80baxwgc | 1) Can you define these terms? |
| cord-285778-80baxwgc | Can You Extrapolate? |
| cord-285778-80baxwgc | How might they also help protect a host against intracellular pathogens? |
| cord-285778-80baxwgc | Overview of the immune response Regulation of adaptive immunity by the innate immune system Friendly and dangerous signals: Is the tissue in control? |
| cord-285778-80baxwgc | Section A 1) Can you define these terms? |
| cord-285778-80baxwgc | What are three major differences between innate and adaptive immune responses? |
| cord-285778-80baxwgc | What exactly triggers the initial response by the innate system? |
| cord-285778-80baxwgc | What happens when the immune system is complete but malfunctions, or when its normal functioning has undesirable effects? |
| cord-285778-80baxwgc | What is the difference between infection and disease? |
| cord-285778-80baxwgc | What is the major difference between extracellular and intracellular pathogens? |
| cord-285778-80baxwgc | What sort of DAMPs and/or PAMPs might be present in each case, and what sorts of immune responses might you expect to find in these patients? |
| cord-285778-80baxwgc | What was Koch's theory and why was it important? |
| cord-285778-80baxwgc | Who coined the term"vaccination"and on what basis? |
| cord-285778-80baxwgc | Why are B lymphocyte responses usually associated with defense against extracellular rather than intracellular pathogens? |
| cord-285778-80baxwgc | Would You Like To Read More? |
| cord-022592-g7rmzsv5 | : a multicentre study Are complete blood cell counts useful in the evaluation of asymptomatic neonates exposed to suspected chorioamnionitis? |
| cord-022592-g7rmzsv5 | Can expression of CD45RO, a T- cell surface molecule, be used to detect congenital infection? |
| cord-022592-g7rmzsv5 | Can neutrophil responses in very low birth weight infants predict the organisms responsible for late- onset bacterial or fungal sepsis? |
| cord-022592-g7rmzsv5 | Does IVIg administration yield improved immune function in very premature neonates? |
| cord-022592-g7rmzsv5 | Echocardiogram done early in neonatal sepsis: what does it add? |
| cord-022592-g7rmzsv5 | Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach Prevention of lymphocyte apoptosisa potential treatment of sepsis? |
| cord-022592-g7rmzsv5 | Increased CD4+ T cell co- inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble- CEACAM1 in meningococcal sepsis: a role in sepsis- associated immune suppression? |
| cord-022592-g7rmzsv5 | New synthetic surfactants: the next generation? |
| cord-022592-g7rmzsv5 | The expression of surface tissue factor apoprotein by blood monocytes in the course of infections in early infancy Complement and coagulation: strangers or partners in crime? |
| cord-022592-g7rmzsv5 | The platelet hyporeactivity of extremely low birth weight neonates is age- dependent The Ashwell receptor mitigates the lethal coagulopathy of sepsis Platelet count and sepsis in very low birth weight neonates: is there an organism- specific response? |
| cord-022592-g7rmzsv5 | Where? |
| cord-022592-g7rmzsv5 | Where? |
| cord-022592-g7rmzsv5 | Which inotrope for which baby? |
| cord-022592-g7rmzsv5 | Why have clinical trials in sepsis failed? |
| cord-022592-g7rmzsv5 | Why? |
| cord-022592-g7rmzsv5 | Why? |
| cord-022592-g7rmzsv5 | when? |
| cord-022592-g7rmzsv5 | when? |
| cord-021966-5m21bsrw | > Having chosen an antigen and presentation system, what is the best way to produce it on a large scale? |
| cord-021966-5m21bsrw | A review of the Vaccine Adverse Event Reporting System database Vaccine safety surveillance using large linked databases: opportunities, hazards and proposed guidelines Permanent brain damage and pertussis vaccination: is the end of the saga in sight? |
| cord-021966-5m21bsrw | Can a specific antigen( or antigens) be identified that represents the target of protective host immune responses? |
| cord-021966-5m21bsrw | Can the pathogen be grown in culture? |
| cord-021966-5m21bsrw | Even larger phase IIb studies can provide additional data on vaccine safety and immunogenicity in subjects generally representative of those for whom the vaccine might be recommended, but importantly, also provide the first opportunity to address to answer the question,'Does this vaccine work in humans?' |
| cord-021966-5m21bsrw | If natural immunity capable of preventing re- infection follows an initial infection with the pathogen, can a specific host immune effector mechanism( e.g., antibody, CD8 T- cell) be identified as the likely agent( or'correlate') of immune protection? |
| cord-021966-5m21bsrw | If so, can a threshold level of this specific immune correlate needed for protection from re- infection be defined? |
| cord-021966-5m21bsrw | If so, does the pathogen cause such a life- threatening disease that an attenuated version of the virus would face an impossible barrier for demonstration of safety? |
| cord-021966-5m21bsrw | If the infection occurs relatively rarely in an overall population, can a subset of the population be identified that has a higher risk of infection so as to accelerate the achievement of statistically significant protection? |
| cord-021966-5m21bsrw | If the protective immune response is mediated by antibodies, can the target antigen( be it a protein or polysaccharide) be produced in scalable quantities in a form that mimics its native structure so that it can effectively elicit antibody responses that can block the key functional role(s) of the target molecule in the pathogen lifecycle or otherwise lead to the clearance of an incipient pathogen infection? |
| cord-021966-5m21bsrw | Is immunity to a given antigen associated with protection against disease following re- exposure in the context of natural infection? |
| cord-021966-5m21bsrw | Is the antigen of interest sufficiently immunogenic on its own, or is augmentation of the desired immune response by conjugation to a specific carrier or addition of an adjuvant necessary to elicit a sufficient and sufficiently durable immune response in individuals in the target population for vaccination? |
| cord-021966-5m21bsrw | Is this subset sufficiently similar to the rest of the population to enable extrapolation of the clinical results to the broader target population as a whole? |
| cord-021966-5m21bsrw | Recent advances in the development of HIV-1 vaccines using replication- incompetent adenovirus vectors One step forward, two steps back-will there ever be an AIDS vaccine? |
| cord-021966-5m21bsrw | The MMR vaccination and autism controversy in United Kingdom 1998- 2005: inevitable community outrage or a failure of risk communication? |
| cord-021966-5m21bsrw | What are the major unmet medical and public health needs today? |
| cord-021966-5m21bsrw | What is known about the natural history and pathogenic mechanisms of the infection of interest? |
| cord-021966-5m21bsrw | What is the attack rate of the infection in the general population? |
| cord-021966-5m21bsrw | What is the most effective way to present the antigens of the pathogen of interest to the immune system? |
| cord-021966-5m21bsrw | What tests to evaluate vaccine immunogenicity will need to carried out on clinical samples obtained from participants in the clinical trials? |
| cord-021966-5m21bsrw | What types of potential safety concerns can be anticipated for the vaccine in question? |
| cord-021966-5m21bsrw | Will measurement of antibody titers, T- cell responses, pathogen presence and quantity, pathogen serotype, and any other parameter peculiar to the disease in question represent the primary criteria for vaccine effect? |
| cord-257167-rz4r5sj7 | ( 1) Which type of brain infarction will be a future target of this therapeutic approach? |
| cord-257167-rz4r5sj7 | ( 2) Which phase of brain infarction( i.e., acute or chronic phase) will be selected as a future timing of therapeutic intervention? |
| cord-257167-rz4r5sj7 | ( 3) Which will be the best way to be applied in the clinical settings, neurogenesis control, stem cell supply or both? |
| cord-257167-rz4r5sj7 | Are NSF and VCP playing complementary or antagonistic roles? |
| cord-257167-rz4r5sj7 | How are brains controlled molecularly? |
| cord-257167-rz4r5sj7 | How can a material object became aware of the world around it and of its very own awareness? |
| cord-257167-rz4r5sj7 | How do pictorial cues influence 3D information processing in the parietal association cortex? |
| cord-257167-rz4r5sj7 | How do these neurons integrate signals from V1? |
| cord-257167-rz4r5sj7 | How do we deal with timing in the brain? |
| cord-257167-rz4r5sj7 | How do we determine what is good or bad for the maturing brain? |
| cord-257167-rz4r5sj7 | How does the brain order successive events? |
| cord-257167-rz4r5sj7 | How is olfactory receptor- dependent axonal wiring conducted? |
| cord-257167-rz4r5sj7 | How relevant is it in protein synthesis- dependent late- phase plasticity( LP)? |
| cord-257167-rz4r5sj7 | In particular, does the well- known columnar organization of V1 play a role in determining the shape selectivity of higher- order neurons? |
| cord-257167-rz4r5sj7 | It is open question, however, if the brain correctly compensates the difference of the relative position of eyes to the head? |
| cord-257167-rz4r5sj7 | JST.ERATO, HFSP SY2- 2- 08- 4 Why look there? |
| cord-257167-rz4r5sj7 | PS3P- G101 Is"seronegative"MG explained by autoantibodies to MuSK? |
| cord-257167-rz4r5sj7 | Thirty tasks were presented visually every 30 s, the subjects were asked to think about the question immediately following the sentences and asked not to think moreover if the question was difficult( e.g., How to cook curried rice? |
| cord-257167-rz4r5sj7 | This raises urgent and important ethical questions for our consideration: is there an"ideal"brain we should be nurturing? |
| cord-257167-rz4r5sj7 | To what extent can/ should drugs be used not merely to correct developmental disorders but also to enhance performance? |
| cord-257167-rz4r5sj7 | Which is essential? |
| cord-257167-rz4r5sj7 | Why do we look where we do? |
| cord-257167-rz4r5sj7 | or How to fold paper into a turtle? etc). |
| cord-031081-szqrjxq2 | Are responses and adaptations ephemeral such that consumers revert to their pre- threat behavior once the threat has passed, or do some of the responses and adaptations"stick,"resulting in longer- term changes? |
| cord-031081-szqrjxq2 | Are these new customers likely to stay? |
| cord-031081-szqrjxq2 | Are they universal, or are there key boundary conditions and moderators that come to bear? |
| cord-031081-szqrjxq2 | As another example, given that an effective coping response can be for a consumer to draw upon her or his social network, how will or should consumers cope when the threat is also being faced by their social network or in- group? |
| cord-031081-szqrjxq2 | As one example, does the extent to which others are likewise impacted change how a consumer responds to her or his own negative event? |
| cord-031081-szqrjxq2 | Bellezza, Paharia, and Keinan( 2017) find that being busy at work is considered a status symbol; however, in the work from home age, how is busyness defined? |
| cord-031081-szqrjxq2 | Do these trade- offs have different implications under economic threat? |
| cord-031081-szqrjxq2 | Does this mean that psychological distance moderates consumer sensitivity to the scope of an imminent threat? |
| cord-031081-szqrjxq2 | How Am I Doing? |
| cord-031081-szqrjxq2 | How do consumers balance conflicting forces from multiple threats? |
| cord-031081-szqrjxq2 | How do consumers react to widespread threats versus local ones? |
| cord-031081-szqrjxq2 | How do consumers respond and adapt to sudden and widespread threats such as these? |
| cord-031081-szqrjxq2 | How do consumers'responses impact the market and reflect back to influence disruption? |
| cord-031081-szqrjxq2 | If so, what factors induce ephemeral versus enduring adaptations to threats? |
| cord-031081-szqrjxq2 | In terms of tangible products, are products that are closer to the self( e.g., clothing) likely to be shared less than those that might be more distant( e.g., bicycles)? |
| cord-031081-szqrjxq2 | Is status conferred by being able to manage both work and household duties, since these often intermingle? |
| cord-031081-szqrjxq2 | Is this true in times of widespread threat, when the importance of digital goods is higher because they are consumers'lifeline to the world? |
| cord-031081-szqrjxq2 | Many employees( including faculty) have received pay reductions; how do responses depend upon whether others are experiencing the same cut? |
| cord-031081-szqrjxq2 | Or is this effect countered by the personal implications of the imminent threat? |
| cord-031081-szqrjxq2 | Perceived Financial Well- Being, Its Potential Antecedents, and Its Relation to Overall Well- Being Human Threat Management Systems: Self- Protection and Disease Avoidance Better or Different? |
| cord-031081-szqrjxq2 | Still Ca n't Buy Toilet Paper? |
| cord-031081-szqrjxq2 | What about when combined with health threat? |
| cord-031081-szqrjxq2 | What are characteristics of products and services that might survive the crisis? |
| cord-031081-szqrjxq2 | What are the most common responses? |
| cord-031081-szqrjxq2 | What is a Disaster?: |
| cord-031081-szqrjxq2 | What kinds of identity do people have around being( or not being) an"essential"worker, and how does this affect consumption? |
| cord-031081-szqrjxq2 | What might be different moderators of this relationship? |
| cord-031081-szqrjxq2 | What types of social comparison occur? |
| cord-031081-szqrjxq2 | When and how are servicescapes likely to provide this therapeutic role for consumers experiencing disruption following contagion or economic threats? |
| cord-015021-pol2qm74 | ( 3) Should future clinical trials be based on new classifications of illness such as MODS, SIRS, APACHE III, SAP II, MRM, etc., or should trials be dedicated to specific diseases-urinary tract infections, pneumonia, trauma patients, cardiac surgery and other specific problems, rather than generalized problems of sepsis, the sepsis syndrome and other classifications? |
| cord-015021-pol2qm74 | 3-Is the ACCP classification of sepsis useful at the bedside to select oatients? |
| cord-015021-pol2qm74 | Abnormally high skeletal muscle pO 2 in septic patients and its normalization during recovery: Evidence against tissue hypoxia but for impaired oxygen metabolism of skeletal muscle? |
| cord-015021-pol2qm74 | Administration of exogenous IFN? |
| cord-015021-pol2qm74 | And, finally, how can the participants be sure that the trial will be stopped at the right time, to ensure that no treatment is given to any patient that might be harmful? |
| cord-015021-pol2qm74 | Are all eligible patients being studied, and their results reported? |
| cord-015021-pol2qm74 | Are all the participants truly unbiased about the relative merits of the regimens being studied? |
| cord-015021-pol2qm74 | Before using the model for risk of death in septic patients, is it mandatory to validate it( by calibration, i.e. goodness of fit, and discrin'dnation, i.e., ROC curves) first on a data base using the same definition for sepsis as in the trial and secondly on the placebo group of the trial? |
| cord-015021-pol2qm74 | Can it achives a significant improvement in the septic course, organ dysfunction, and final outcome? |
| cord-015021-pol2qm74 | Conversely, administration of anti- IFN? |
| cord-015021-pol2qm74 | Correlatively the RNI inhibitor MMLA induces in vitro a decrease in the rate of bacterial killing, fxom 78% to 57%, in macrophages triggered with IFN-?+ LPS. |
| cord-015021-pol2qm74 | How can organ dysfunction and/or failure be defined? |
| cord-015021-pol2qm74 | How should we decide which of them should be brought to clinical trial? |
| cord-015021-pol2qm74 | If there is agreement that thin is an appropriate antibiotic protocol, should it not be used in all seriously ill septic patients in the hospital? |
| cord-015021-pol2qm74 | In contrast, GF109203X significantly reduced ICAM-1 expression induced by Interferon- y( IFN-?) |
| cord-015021-pol2qm74 | In fact, the IFN-? and IL-1 induced adhesion of PBMC to cytokine treated HUVEC could be downregulated by the PKC- inhibitor, whereas TNFc~-and LPS- mediated adhesion was not influenced. |
| cord-015021-pol2qm74 | In other words, should we now begin to have clinical trials on specific diseases with causes that are known and can be attacked? |
| cord-015021-pol2qm74 | Interferon-? |
| cord-015021-pol2qm74 | Is like being compared with like-are all the end points and the standards for measuring them clearly defined so that they can not be misunderstood? |
| cord-015021-pol2qm74 | Is there any role for antioxidative therapy in sepsis? |
| cord-015021-pol2qm74 | Is truly informed consent being sought that will satisfy not only the patient's right to choose what happens to him, but also the law of the land? |
| cord-015021-pol2qm74 | MIF secretion also was induced by TNFoc( 1 ng/ ml) and IFN? |
| cord-015021-pol2qm74 | MIF secretion is induced by LPS, TNFc~ and IFN?. |
| cord-015021-pol2qm74 | Macrophages of C57BL/10ScCr mice are incapable of producing interferon-~( IFN~) which we could show to be obligatory for the production of IFN? |
| cord-015021-pol2qm74 | On closer investigation the impaired IFN? |
| cord-015021-pol2qm74 | The IFN? |
| cord-015021-pol2qm74 | The absence of sensitization to LPS in Lps d C57BL/10ScCr mice was identified as being due to their inability to produce interferon-7( IFN?). |
| cord-015021-pol2qm74 | The clinical"take"rate o? cultured epithelial autografts( CEA) has been observed to Increase with transplantation to allodermls, but the reasons for the improved clinical performance have not yet been defined. |
| cord-015021-pol2qm74 | The inability to produce adequate amounts of IL-2, most likely attributable to alterations in the transmission of signals from the cell membrane to the nucleus, results in incomplete proliferative T- cell responses to antigenic stimuli, while a lack of? |
| cord-015021-pol2qm74 | There are reports of nentrophil dysfunction in inflammatory disorders of the skin( 2), Are there dysfunctions concerning the unspecific host defense in SIRS, as well? |
| cord-015021-pol2qm74 | This has not happened, however, and the question is"Why not"? |
| cord-015021-pol2qm74 | This might be due to a preexisting( genetic?) or more likely to an epiphenomenal receptor defect. |
| cord-015021-pol2qm74 | We have investigated the proinflaznmatory oytokine secretion patter~ by PMN in patients following major~hermal or tra~ matic injury and in volunteers fellowinq endotoxemia.? |
| cord-015021-pol2qm74 | What are the definitions? |
| cord-015021-pol2qm74 | What are the issues, then, in 1994, to be dealt with at this symposium and congress? |
| cord-015021-pol2qm74 | What are the mechanisms? |
| cord-015021-pol2qm74 | What is the aplpiieability of study results in typical clinical situations? |
| cord-015021-pol2qm74 | What is the availability of speciftc antibiotics at a participating hospital? |
| cord-015021-pol2qm74 | Will the patient's physicians agree to the protocol choice? |
| cord-015021-pol2qm74 | Will they be helpful in the study and esro of patients? |
| cord-015021-pol2qm74 | Will this contribute to better clinical trials, information basis and better research? |
| cord-015021-pol2qm74 | Will we benefit Oleo from a more precise classification and definition of a non- outjty, a hodgu- podge of human disorders which have charsmeristic.s and manifestations of tissue injury, inflammation and infactian? |
| cord-015021-pol2qm74 | and?-IFN and T- helper-2( Th2) acting principally in inducing antibody formation with a secretion of IL-4, IL-5, IL-10 and TNF-[3 has still to be established within the context of major trauma. |
| cord-015021-pol2qm74 | anti- IFN-?( p<0.05). |
| cord-015021-pol2qm74 | or is it better to use a specific model for each trial? |
| cord-015021-pol2qm74 | ~is s?. |