bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
immune response	1377
immune responses	1227
immune system	541
innate immune	503
gene expression	459
class i	415
results suggest	398
dendritic cells	382
inflammatory response	329
infectious diseases	312
cell responses	311
type i	308
dna vaccines	307
present study	295
influenza virus	294
dna vaccine	278
research funds	268
mg kg	266
virus infection	265
public health	257
septic shock	255
epithelial cells	237
adaptive immune	236
cell surface	233
peripheral blood	232
antibody responses	218
important role	215
cytokine production	206
clinical trials	201
disaster response	197
mhc class	193
bone marrow	192
cell lines	192
cell activation	186
respiratory syndrome	186
infected cells	185
vaccine development	185
necrosis factor	182
cd cd	180
graduate school	180
immune cells	180
innate immunity	180
infectious disease	179
inflammatory cytokines	176
host response	171
lymph nodes	170
nervous system	166
delivery systems	163
cell death	162
data suggest	161
pg ml	160
like receptor	160
vaccine delivery	160
results indicate	158
flow cytometry	157
amino acid	153
cell types	153
animal models	151
transcription factor	148
cell line	148
tumor necrosis	148
acute respiratory	147
high levels	146
cell receptor	145
antibody response	143
plasmid dna	143
cell proliferation	142
disaster management	142
antigen presentation	141
cell response	139
viral infection	138
fatty acids	138
host immune	136
may also	136
protective immunity	135
presenting cells	135
specific cd	132
ng ml	132
neutralizing antibodies	130
oxidative stress	128
influenza vaccine	128
nitric oxide	127
mast cells	126
signaling pathways	123
significantly higher	123
monoclonal antibodies	122
dna vaccination	122
organ failure	121
cellular immune	120
public sentiment	119
adhesion molecules	119
viral replication	118
mononuclear cells	117
class ii	114
live attenuated	114
significantly reduced	114
significantly increased	114
cd cells	114
may contribute	114
endothelial cells	113
recent studies	113
molecular mechanisms	110
monoclonal antibody	109
lymph node	109
viral infections	109
deficient mice	108
united states	108
severe acute	107
cord uid	107
doc id	107
protein kinase	106
signal transduction	106
mrna expression	105
dependent manner	105
control group	105
mouse model	104
delivery system	104
inflammatory responses	104
like receptors	104
binding protein	103
th cells	102
stress response	102
wild type	100
central nervous	99
specific immune	99
proinflammatory cytokines	98
amino acids	97
adaptive immunity	96
endoplasmic reticulum	96
nk cells	96
transgenic mice	95
i ifn	95
humoral immune	92
specific ctl	91
may play	91
syncytial virus	90
antigen presenting	90
spinal cord	90
mucosal immune	89
respiratory tract	89
respiratory syncytial	89
dendritic cell	89
i molecules	88
growth factor	88
vaccinia virus	88
mediated immune	87
virus infections	86
previous studies	86
ctl response	85
nkt cells	84
results show	84
immunodeficiency virus	82
acute phase	81
progenitor cells	81
multiple organ	80
i interferon	80
clinical trial	80
findings suggest	80
neonatal sepsis	80
rheumatoid arthritis	80
virus replication	80
ctl responses	79
er stress	79
national institute	78
spleen cells	77
may lead	77
inflammatory diseases	77
transcription factors	77
target cells	76
protein expression	76
phase i	75
blood samples	75
septic patients	75
inflammatory mediators	75
critical role	75
airway epithelium	74
natural killer	73
tissue damage	73
taken together	73
host cells	73
surface expression	73
mechanisms underlying	72
based vaccines	72
blood mononuclear	72
infected mice	72
expression levels	71
antiviral response	71
time points	71
ex vivo	71
antibody titers	71
reactive oxygen	70
protective immune	70
lung injury	70
host defense	70
tumor cells	70
dna damage	70
side effects	68
syndrome coronavirus	68
host cell	68
vaccine adjuvants	67
airway epithelial	67
heat shock	67
human immunodeficiency	67
also observed	67
specific antibodies	67
positive cells	67
mediated immunity	66
hla class	66
neuronal activity	66
plasma membrane	65
severe sepsis	65
significant increase	65
plasma cells	65
purkinje cells	65
cell cycle	65
cgas sting	65
significantly decreased	65
infected patients	65
receptor antagonist	65
hippocampal neurons	64
mycobacterium tuberculosis	64
viral proteins	64
stem cells	64
research institute	64
immune function	63
clinical studies	63
large number	63
significant differences	63
knockout mice	63
mast cell	63
herpes simplex	63
cerebral cortex	63
neutralizing antibody	62
brain science	62
intensive care	62
airway inflammation	62
vaccine antigens	62
cell epitopes	62
cytosolic dna	62
prefrontal cortex	62
gene delivery	62
molecular patterns	61
also found	61
higher levels	61
infl ammatory	61
molecular weight	61
antigen processing	61
two groups	60
cell population	60
cellular responses	60
cell subsets	60
hiv infection	60
subunit vaccines	59
virus type	59
simplex virus	59
healthy volunteers	59
inflammatory cytokine	59
ifn response	59
cell development	58
cellular immunity	58
whole blood	58
university school	58
surface antigen	58
cells expressing	58
protein synthesis	58
blood flow	58
visual cortex	57
multiple sclerosis	57
key role	57
escherichia coli	57
emergency management	57
situ hybridization	57
cell culture	57
mrna levels	57
preterm infants	57
plasma levels	57
fatty acid	56
cell populations	56
also known	56
recognition receptors	56
inkt cells	56
effector cells	56
animal model	56
ko mice	56
specific antibody	56
cell membrane	55
crucial role	55
autoimmune diseases	55
data indicate	55
synaptic transmission	55
cell adhesion	54
healthy controls	54
middle east	54
increased expression	54
cell type	54
ebola virus	54
previously reported	54
protein antigens	54
vaccine formulations	54
days post	54
cell clones	54
increased risk	54
response strategies	54
systemic inflammatory	53
cell differentiation	53
high affinity	53
associated molecular	53
epithelial cell	53
pattern recognition	53
analysis revealed	53
drug delivery	53
significant difference	53
organ dysfunction	53
gene products	53
serum levels	53
nuclear factor	52
immune activation	52
chronic inflammatory	52
viral load	52
pandemic response	52
western blot	52
determine whether	52
different types	52
adhesion molecule	52
respiratory distress	52
systems biology	52
vaccine efficacy	52
influenza vaccines	52
blood pressure	52
infected individuals	52
results demonstrate	52
mutant mice	52
nk cell	51
university graduate	51
mucosal immunity	51
mice showed	51
like particles	51
smooth muscle	51
critically ill	51
rna viruses	50
nucleic acid	50
central role	50
factors influencing	50
vg vd	50
maternal antibodies	50
kyoto university	50
increased levels	50
osaka univ	50
mice immunized	50
producing cells	50
results showed	50
stress responses	49
wide range	49
risk factors	49
social distancing	49
reactive protein	49
based vaccine	49
virus vaccine	49
west nile	49
significantly lower	49
bl mice	49
poorly understood	49
neural stem	49
dna encoding	48
draining lymph	48
health care	48
first time	48
type mice	48
previously shown	48
signaling pathway	48
recent years	48
genes involved	48
th responses	48
cd expression	48
immune cell	48
onset sepsis	48
oxygen species	48
apoptotic cells	48
differentially expressed	48
synaptic plasticity	47
seasonal influenza	47
infectious agents	47
chronic inflammation	47
east respiratory	47
mucosal vaccines	47
stranded rna	47
cortical neurons	47
studies using	47
two different	47
antigen delivery	47
humoral immunity	47
treated mice	47
cell function	46
viral rna	46
major histocompatibility	46
host responses	46
time course	46
activated protein	46
bacterial infections	46
healthy individuals	46
physical activity	46
medical school	46
healthy subjects	46
th th	46
nile virus	46
influenza vaccination	46
lymphoid tissues	46
skeletal muscle	46
cytokine storm	46
disease virus	46
adverse events	46
immune complexes	46
protective effect	46
cytokine levels	46
body weight	46
stimulating factor	45
control mice	45
viral vectors	45
type ii	45
gene therapy	45
recent study	45
synthetic peptides	45
protective efficacy	45
yellow fever	45
long term	45
mental health	45
adrenergic receptor	45
emergency response	45
phase iii	45
nucleic acids	45
growth factors	45
systematic review	44
fold increase	44
protein levels	44
glial cells	44
disease susceptibility	44
mechanisms involved	44
physical exercise	44
protein response	44
may provide	44
porcine reproductive	44
cytokine release	44
performed using	44
stem cell	44
chicken embryo	43
disease progression	43
major role	43
older adults	43
inflammatory bowel	43
respiratory disease	43
pyramidal neurons	43
new vaccine	43
cholera toxin	43
developing countries	43
tlr agonists	43
adaptive response	43
two distinct	43
gene transfer	43
vaccine design	43
influenza infection	43
highly conserved	43
better understanding	43
distress syndrome	42
mucosal vaccine	42
gold nanoparticles	42
autoimmune disease	42
cytokine responses	42
hcv core	42
systemic lupus	42
effector functions	42
tnf production	42
low levels	42
cells may	42
i ifns	42
specific igg	42
extracellular matrix	42
vaccine adjuvant	42
well known	42
pregnant women	42
two types	42
phase ii	42
hemorrhagic shock	41
disease response	41
science institute	41
negative bacteria	41
peritoneal macrophages	41
allergic asthma	41
wistar rats	41
statistically significant	41
olfactory bulb	41
studies suggest	41
national authorities	41
humoral responses	41
even though	41
i response	41
nmda receptor	41
data show	41
granule cells	41
birth weight	41
antibody production	41
intranasal administration	41
recent advances	41
membrane protein	40
crisis response	40
environmental factors	40
systemic immune	40
tlr ligands	40
pyramidal cells	40
nanoparticle vaccines	40
dynamic capabilities	40
lupus erythematosus	40
antiviral immune	40
syndrome virus	40
severe disease	40
medical university	40
inhibitory effect	40
unfolded protein	40
mucosal adjuvants	40
blot analysis	40
gnrh neurons	40
wound healing	39
cell biology	39
responses induced	39
vaccine formulation	39
mucosal surfaces	39
early life	39
receptor expression	39
fl uid	39
intracellular pathogens	39
helper cells	39
influenza viruses	39
inflammatory cells	39
chronic stress	39
hippocampal slices	39
will discuss	39
novel coronavirus	39
global health	39
world health	39
osaka university	39
antiviral responses	38
cancer cells	38
preclinical studies	38
may represent	38
fold change	38
igg antibodies	38
important roles	38
cell activity	38
adipose tissue	38
oxide synthase	38
cells showed	38
oral vaccines	38
mesenteric lymph	38
new york	38
endothelial cell	38
large amounts	38
data demonstrate	38
avian influenza	38
adjuvant activity	38
may result	37
ca i	37
vaccination strategies	37
normal mice	37
cell wall	37
cord blood	37
myeloid cells	37
rat brain	37
chronic hepatitis	37
low birth	37
previous study	37
may explain	37
investigated whether	37
mice infected	37
fusion protein	37
ubiquitin ligase	37
disaster prevention	37
several studies	37
candidate genes	37
controlled trial	37
health organization	37
attenuated vaccines	37
cell repertoire	37
psychological stress	37
mice lacking	36
iga antibodies	36
inhibitory effects	36
oral vaccine	36
immune evasion	36
disease severity	36
alveolar macrophages	36
ms patients	36
dentate gyrus	36
bowel disease	36
response system	36
survival rate	36
histocompatibility complex	36
cell migration	36
remains unclear	36
dengue virus	36
rainbow trout	36
differential expression	36
cytokine secretion	36
heart rate	36
cytokine response	36
viral variants	36
local governments	36
tissue injury	36
iga responses	36
zika virus	36
time pcr	36
sars coronavirus	36
mhc i	36
care unit	36
response matching	36
management system	35
binding site	35
ca region	35
barrier function	35
target cell	35
interferon response	35
vaccine candidate	35
pandemic influenza	35
upper respiratory	35
rhesus macaques	35
core protein	35
tyrosine kinase	35
crisis management	35
following infection	35
bacterial infection	35
trauma patients	35
disaster medicine	35
complement activation	35
inflammatory process	35
high level	35
tumor growth	35
proinflammatory cytokine	35
mass spectrometry	35
expression patterns	35
cells express	35
lung function	35
proliferative response	35
facs analysis	34
ctl escape	34
risk communication	34
disaster risk	34
ifn production	34
cells play	34
reticulum stress	34
dna immunization	34
weight infants	34
plasmodium falciparum	34
wide variety	34
protection motivation	34
commonly used	34
closely related	34
memory cells	34
time point	34
infectious bronchitis	34
functional genomics	34
future studies	34
research center	34
will also	34
i interferons	34
human monocytes	34
preterm neonates	34
cardiac output	34
coronavirus infection	34
family members	33
significant reduction	33
kyoto univ	33
th response	33
promoter region	33
mouse models	33
cell mediated	33
future research	33
muscle cells	33
membrane potential	33
pivotal role	33
specific cytotoxic	33
model system	33
lung tissue	33
molecular mechanism	33
monophosphoryl lipid	33
expression level	33
vaccine candidates	33
signalling pathways	33
intranasal immunization	33
ill patients	33
takes place	33
significant role	33
host innate	33
well tolerated	33
study showed	33
tohoku university	33
blood cells	33
immunized mice	33
widely used	33
response induced	33
bronchoalveolar lavage	33
conjugate vaccine	33
single cell	33
subunit vaccine	32
cells also	32
real time	32
examined whether	32
tohoku univ	32
rat hippocampal	32
plasmacytoid dendritic	32
adverse effects	32
fish oil	32
early stages	32
expression profiling	32
dna delivery	32
respiratory infections	32
dna sensing	32
humoral response	32
asthma patients	32
genes associated	32
new vaccines	32
inflammatory processes	32
significant decrease	32
substantia nigra	32
pathological changes	32
emerging infectious	32
sting pathway	32
signal activation	32
lymphoid tissue	32
chitosan nanoparticles	32
response may	32
cell membranes	32
cell signaling	32
dna methylation	32
also shown	32
acute pancreatitis	32
large numbers	31
tumour necrosis	31
pseudomonas aeruginosa	31
naked dna	31
may cause	31
tlr agonist	31
microarray analysis	31
haemophilus influenzae	31
cells via	31
human disease	31
expression changes	31
studies showed	31
growth cone	31
ctl epitopes	31
injection site	31
therapeutic potential	31
oral delivery	31
studies indicate	31
mhc molecules	31
cationic liposomes	31
western blotting	31
viral antigens	31
control animals	31
expression profiles	31
statistical analysis	31
whole cell	31
mg ml	31
single dose	31
associated lymphoid	31
nasal vaccination	31
free radicals	31
ctl clones	31
elevated levels	31
naturally occurring	31
significantly different	31
equine influenza	31
host factors	30
recombinant protein	30
outer membrane	30
significantly enhanced	30
binding proteins	30
natural disasters	30
protective effects	30
candidate gene	30
factor alpha	30
tokyo metropolitan	30
previously described	30
largely unknown	30
vitro studies	30
may help	30
short term	30
human health	30
node cells	30
three different	30
immune systems	30
cellular response	30
receptor signaling	30
response syndrome	30
nkt cell	30
hiv vaccine	30
brain regions	30
immune mechanisms	30
least two	30
reverse vaccinology	30
arachidonic acid	30
host damage	30
antibody levels	30
lactic acid	30
viral vector	30
cytokines il	30
bacterial translocation	30
malaria vaccine	30
low dose	30
results suggested	30
mouse brain	30
coronavirus disease	29
viral particles	29
animal studies	29
results indicated	29
adaptive responses	29
surface markers	29
high frequency	29
receptor activation	29
total rna	29
risk management	29
authors declare	29
treated animals	29
analysis showed	29
antigen receptor	29
cell receptors	29
oral administration	29
nasal epithelium	29
gram negative	29
atopic dermatitis	29
least one	29
cells infected	29
natural infection	29
polyunsaturated fatty	29
induced apoptosis	29
cell recognition	29
new approaches	29
microbial pathogenesis	29
risk factor	29
tetanus toxoid	29
life cycle	29
blood vessels	29
innate response	29
adoptive transfer	29
highly expressed	29
vaccine responses	29
systemic inflammation	29
th cytokines	29
murine model	29
clinical signs	29
allergic inflammation	29
genetic variation	29
oral vaccination	29
thermal injury	29
expressed genes	28
biological activity	28
viral clearance	28
tgev infection	28
basal ganglia	28
oral immunization	28
may occur	28
pc cells	28
nagoya university	28
expression profi	28
also able	28
guinea pigs	28
serum igg	28
intranasal vaccination	28
molecular biology	28
digital technologies	28
human clinical	28
stress resilience	28
vaccine vectors	28
findings indicate	28
antigenic peptides	28
university hospital	28
projection neurons	28
group i	28
intranasal delivery	28
immunological memory	28
sepsis syndrome	28
healthy donors	28
different cell	28
transforming growth	28
human cd	28
type diabetes	28
newborn infants	28
riken brain	28
muc ac	28
human peripheral	28
macrophage activation	28
apache ii	28
cell immunity	28
specific iga	28
lymphoid cells	28
cell epitope	28
studies show	27
also showed	27
epithelial barrier	27
cytokine expression	27
beneficial effects	27
secretory iga	27
west africa	27
free radical	27
government response	27
response network	27
ros production	27
gene promoter	27
mortality rate	27
body temperature	27
better understand	27
sensory neurons	27
auditory cortex	27
vaccine safety	27
significantly elevated	27
studies revealed	27
small intestine	27
neural network	27
modified vaccinia	27
response plan	27
gamma delta	27
also increased	27
inflammatory disease	27
mortality rates	27
early stage	27
dna sensor	27
motor neurons	27
vascular permeability	27
common cold	27
high degree	27
identifi ed	27
passive protection	27
plasma concentrations	27
helper cell	27
high dose	27
blood donors	27
neural activity	27
proliferative responses	27
brain function	27
different stages	26
rat model	26
reperfusion injury	26
genetic factors	26
mean age	26
hippocampal ca	26
immune complex	26
single cells	26
asthma exacerbations	26
lymphocyte responses	26
clinical course	26
new therapeutic	26
cell rna	26
bronchial epithelial	26
provide evidence	26
receptive field	26
crisis responses	26
inflammatory effects	26
mucosal iga	26
deer mice	26
first line	26
cause disease	26
antigen specific	26
binding sites	26
type immune	26
one hand	26
neurite outgrowth	26
weight loss	26
many different	26
complement system	26
may reflect	26
phase proteins	26
transmissible gastroenteritis	26
induced arthritis	26
primary infection	26
promoter activity	26
recombinant human	26
currently available	26
expression pattern	26
mammalian cells	26
newcastle disease	26
stimulatory molecules	26
insulin resistance	26
specific cellular	26
antimicrobial peptides	26
linked poly	26
electron microscopy	26
vaccine antigen	26
information processing	26
analysis using	25
soluble tnf	25
brain injury	25
blood lymphocytes	25
ctl activity	25
viral protein	25
serine protease	25
cancer patients	25
new insights	25
cell cultures	25
surface receptors	25
infected cell	25
dose dependent	25
cell growth	25
chain reaction	25
human papillomavirus	25
produce il	25
pupil diameter	25
particle size	25
cancer cell	25
young children	25
essential role	25
novel therapeutic	25
mouse strains	25
life science	25
healthy adults	25
term potentiation	25
wt mice	25
human diseases	25
systems vaccinology	25
profi ling	25
data sets	25
mice treated	25
may affect	25
light reflex	25
ibv infection	25
langerhans cells	25
induced cytokine	25
i mhc	25
sendai virus	25
bronchitis virus	25
south korea	25
first days	25
gabaergic neurons	25
vitro stimulation	25
cytokine profile	25
tlr expression	25
candidate vaccines	25
cell immune	25
phagocytic cells	25
map kinase	25
lps challenge	25
dopaminergic neurons	25
cancer immunotherapy	25
human immune	25
negative sepsis	25
cell level	25
results obtained	25
high concentrations	25
fever virus	25
emerging pathogens	25
local government	25
ml kg	25
may induce	24
blood cell	24
therapeutic agents	24
therapeutic targets	24
adaptor protein	24
well established	24
lymphoid organs	24
cell analysis	24
induced immune	24
expressing cells	24
polymerase chain	24
foreign antigens	24
arterial pressure	24
receptor gene	24
recently reported	24
disease control	24
vaccine strategies	24
core expression	24
may influence	24
purkinje cell	24
shock proteins	24
secreted protein	24
patients undergoing	24
early phase	24
transgenic mouse	24
united kingdom	24
immune surveillance	24
genomic dna	24
evidence suggests	24
apoptotic cell	24
neuropathic pain	24
ganglion cells	24
phagocytic activity	24
responses following	24
virus ankara	24
associated protein	24
another study	24
host interactions	24
also reported	24
cd mab	24
response genes	24
rabies virus	24
block copolymers	24
core gene	24
vaccine immunogenicity	24
investigate whether	24
hydrogen peroxide	24
negatively charged	24
infection may	24
immune functions	24
transcriptional response	24
mucosal adjuvant	24
nanoparticle vaccine	24
patients suffering	24
venous blood	24
information sharing	24
igg responses	24
human cells	24
antigen expression	24
within hours	24
health emergencies	24
studies demonstrated	24
whole genome	24
th cell	24
neuronal cell	24
tnf receptor	24
red blood	24
immune protection	24
inactivated influenza	24
tg mice	24
human rotavirus	24
gastrointestinal tract	24
dorsal root	24
brain development	24
locomotor activity	24
small number	24
hcv infection	24
related genes	24
still unclear	24
secreting cells	24
response framework	24
significantly inhibited	24
inflammatory conditions	24
two major	24
i will	24
like particle	24
cov infection	24
big data	24
influencing disaster	23
surface area	23
based nanoparticles	23
randomized controlled	23
nmda receptors	23
treated rats	23
will need	23
respiratory failure	23
white blood	23
bacillus anthracis	23
actin cytoskeleton	23
response time	23
dendritic spines	23
cystic fibrosis	23
tlr signaling	23
effective vaccines	23
marginal zone	23
much less	23
transgene expression	23
result suggests	23
surface proteins	23
defense mechanisms	23
medical research	23
cell memory	23
lessons learned	23
mice compared	23
host defence	23
effective response	23
play important	23
persistent infection	23
vaccine induces	23
neural activities	23
positive correlation	23
fi rst	23
showed significant	23
vitro experiments	23
lps stimulation	23
important factor	23
translation initiation	23
adult mice	23
recombinant proteins	23
male wistar	23
severe asthma	23
expression profile	23
barr virus	23
give rise	23
inflammatory reactions	23
th immune	23
ca pyramidal	23
effective disaster	23
virus core	23
cd cell	23
limiting dilution	23
organ injury	23
pupillary light	23
behavior change	23
activation markers	23
million people	23
acute infection	23
medical center	23
vaccines may	23
nonhuman primates	23
confer protection	23
patients infected	23
gene gun	23
i antigen	23
cell hybridomas	23
beneficial effect	23
glutamate receptor	23
recombinant lactobacillus	22
tnf receptors	22
highly pathogenic	22
transcriptional regulation	22
nerve injury	22
shock protein	22
gene product	22
underlying mechanisms	22
specific antigen	22
restricted cytotoxic	22
control groups	22
fully understood	22
preliminary data	22
igg antibody	22
marked increase	22
fear memory	22
diabetes mellitus	22
lipid peroxidation	22
kinase inhibitors	22
inducible nitric	22
defi ned	22
pathogen recognition	22
post infection	22
inflammatory activity	22
health systems	22
levels increased	22
broadly neutralizing	22
specific response	22
molecular basis	22
wide association	22
significant correlation	22
creative commons	22
dorsal horn	22
nasal delivery	22
days later	22
oxygen delivery	22
recombinant vaccinia	22
cells respond	22
using anti	22
dependent signal	22
lymphocyte proliferation	22
cell infiltration	22
hbv infection	22
patients treated	22
structural proteins	22
measles virus	22
signaling molecules	22
gel electrophoresis	22
primary human	22
staphylococcus aureus	22
cecal ligation	22
tlr ligand	22
dominant negative	22
social media	22
gene transcription	22
gnotobiotic pigs	22
mucosal vaccination	22
induced activation	22
killer cells	22
similar results	22
keio univ	22
binding domain	22
kg day	22
riken bsi	22
cell damage	22
promising results	22
peptide binding	22
term neonates	22
gene encoding	22
colony stimulating	22
cells stimulated	22
also used	22
protein level	22
highly effective	22
confocal microscopy	22
clinical study	22
neuronal differentiation	22
nasal cavity	22
expression analysis	22
monocytes macrophages	22
federal government	22
significant changes	22
cell tolerance	22
informal settlements	22
immune escape	22
biology approach	21
cell transplantation	21
passive immunity	21
infectious agent	21
influenzae type	21
therapeutic vaccines	21
protects mice	21
specific cell	21
specific memory	21
magnetic resonance	21
chronic diseases	21
simulation results	21
neurotrophic factor	21
increased mortality	21
virus vaccines	21
experimental models	21
mhc ii	21
nuclear power	21
organ damage	21
vascular resistance	21
vaccine administration	21
novel vaccine	21
genetic variants	21
surface antigens	21
responses may	21
also important	21
target genes	21
macrophage colony	21
different mechanisms	21
dna virus	21
human airway	21
ebola response	21
cell layer	21
local immune	21
broad spectrum	21
candidate vaccine	21
secreted proteins	21
genes encoding	21
adult rats	21
delivery vehicles	21
mers outbreak	21
lymphocytic choriomeningitis	21
health system	21
surface molecules	21
dna prime	21
increased production	21
ebola outbreak	21
receptor agonists	21
major cause	21
disseminated intravascular	21
many studies	21
specific immunity	21
gut microbiota	21
female mice	21
acute stress	21
systemic immunity	21
new technologies	21
antiviral immunity	21
mucociliary clearance	21
marrow derived	21
neurodegenerative diseases	21
renal failure	21
nuclear translocation	21
goblet cell	21
vaccine vector	21
clinical outcome	21
therapeutic approaches	21
inflammatory mediator	21
motor learning	21
various types	21
inflammatory cell	21
effective vaccine	21
streptococcus pneumoniae	21
surround suppression	21
mediated responses	21
guinea pig	21
novel actors	21
clinical practice	21
tuberculosis infection	21
ii molecules	21
sd model	21
recent work	21
will provide	21
vivo studies	21
transfection efficiency	21
vaccine response	21
recent evidence	21
innate leukocytes	21
working memory	21
genetically engineered	20
primary motor	20
shed light	20
highly purified	20
less likely	20
fluorescent protein	20
th cytokine	20
sequence analysis	20
inflammatory reaction	20
will help	20
cd cytotoxic	20
serum antibodies	20
relatively high	20
high titers	20
modifying therapies	20
regulatory factor	20
cell maturation	20
genetic background	20
well understood	20
reservoir hosts	20
single nucleotide	20
public crisis	20
systemic vascular	20
male rats	20
mediated dna	20
allowed us	20
serum il	20
glycolic acid	20
membrane proteins	20
first step	20
recently identified	20
synaptic vesicles	20
measured using	20
cell functions	20
commercially available	20
receptor antagonists	20
real scenarios	20
heavy chain	20
cells following	20
experimental animals	20
brain activity	20
necrotizing enterocolitis	20
antigen uptake	20
several different	20
including il	20
respiratory viruses	20
take place	20
another important	20
mm hg	20
cell help	20
immunomodulatory activity	20
human volunteers	20
listeria monocytogenes	20
high risk	20
transmitter release	20
unclear whether	20
sle patients	20
mouth disease	20
cpg motifs	20
immune suppression	20
data collection	20
rna interference	20
large scale	20
arterial blood	20
invading pathogens	20
immune tolerance	20
danger signals	20
culture medium	20
growth hormone	20
fos expression	20
plasma cell	20
cell survival	20
potential therapeutic	20
mucosal tissues	20
airway remodeling	20
australian government	20
medical science	20
local disaster	20
cell subset	20
cell numbers	20
innate responses	20
recombinant vaccine	20
lactobacillus vaccine	20
cytokine il	20
choriomeningitis virus	20
civil society	20
interferon gamma	20
induced cell	20
i expression	20
viral pathogens	20
mechanism underlying	20
cell specific	20
level evidence	20
uric acid	20
vaccine encoding	20
gene segments	20
two main	20
receptor agonist	20
nasal mucosa	19
neutrophil elastase	19
neuronal death	19
study aimed	19
gene polymorphisms	19
food intake	19
inflammatory properties	19
synaptic inputs	19
biologically active	19
antibodies directed	19
safety profile	19
medical sciences	19
reverse genetics	19
cd antibodies	19
derived dendritic	19
protein production	19
constitutively expressed	19
adjuvant effect	19
antiviral mabs	19
gene polymorphism	19
ndv infection	19
different time	19
preliminary results	19
chronic disease	19
family member	19
three weeks	19
evidence indicates	19
health threat	19
lavage fluid	19
metropolitan institute	19
airway hyper	19
also induced	19
cytotoxic activity	19
tyrosine phosphorylation	19
cd ro	19
digital transformation	19
electrical stimulation	19
years ago	19
derived macrophages	19
freshly isolated	19
increased susceptibility	19
mean arterial	19
term memory	19
patients without	19
clinical symptoms	19
relatively low	19
cell bodies	19
results provide	19
damage response	19
possible role	19
cells producing	19
public sentiments	19
neuronal migration	19
i restricted	19
tumor cell	19
human skin	19
breast cancer	19
multiple trauma	19
heart disease	19
marrow cells	19
highly immunogenic	19
nagoya univ	19
adjuvant system	19
activating factor	19
es cells	19
axon terminals	19
measles vaccine	19
infected animals	19
cell proliferative	19
vaccines based	19
disease caused	19
northern blot	19
intracellular calcium	19
serum samples	19
st century	19
vaccine based	19
arm model	19
regulatory cells	19
enhanced immune	19
also present	19
studies will	19
determined using	19
quality control	19
intravascular coagulation	19
bacterial sepsis	19
lower respiratory	19
immune recognition	19
neurons showed	19
transduction pathways	19
mediated gene	19
cardiovascular disease	19
burn injury	19
proteins involved	19
antigen recognition	19
increase rate	19
i antigens	19
human subjects	19
disease outbreaks	19
also involved	19
poly i	19
spike protein	19
immune genes	19
severe covid	19
blood transfusion	19
mice developed	18
natural disaster	18
lamina propria	18
based adjuvants	18
also associated	18
human neutrophils	18
cells compared	18
community structure	18
acute lung	18
mice expressing	18
cellular stress	18
vaccine containing	18
acute inflammatory	18
specific antigens	18
ischemia reperfusion	18
adult male	18
gives rise	18
protein folding	18
helicobacter pylori	18
glucocorticoid receptor	18
broad range	18
protective antigen	18
tlr activation	18
i clinical	18
lps injection	18
innate antiviral	18
study also	18
two weeks	18
lps induced	18
trout nalt	18
mediated signaling	18
one group	18
control variables	18
tlr stimulation	18
retinoic acid	18
chronic obstructive	18
immune regulation	18
clonal expansion	18
will require	18
emergency preparedness	18
immune status	18
genetic polymorphisms	18
vaccine production	18
microorganism interaction	18
disease activity	18
one study	18
three times	18
study using	18
bacterial cell	18
rna virus	18
cells using	18
sex differences	18
pulmonary disease	18
without affecting	18
serum antibody	18
response will	18
least three	18
another example	18
salmonella typhimurium	18
killer cell	18
novel adjuvants	18
university medical	18
homeland security	18
converting enzyme	18
mucosal delivery	18
antigen receptors	18
plga nanoparticles	18
well characterized	18
surface protein	18
lymphokine production	18
enhance immune	18
virus dna	18
cell lysis	18
virus particles	18
body surface	18
clinical presentation	18
peptide vaccine	18
cytokine profiles	18
low doses	18
three groups	18
major surgery	18
may act	18
may increase	18
germinal center	18
virulence factors	18
action potentials	18
lower levels	18
white matter	18
association studies	18
type virus	18
preclinical models	18
emergency nurses	18
inducible gene	18
mucosal immunization	18
negative regulator	18
chemokine receptor	18
escape mutations	18
analyzed using	18
placebo group	18
life sciences	18
abdominal sepsis	18
escape viral	18
human brain	18
inflammasome activation	18
protective role	18
kupffer cells	18
immersion vaccination	18
effective immune	18
virus challenge	18
aids vaccine	18
strong immune	18
digital technology	18
costimulatory molecules	18
incubation period	18
recently shown	18
silica nanoparticles	18
blood levels	18
years old	18
mice exhibited	18
limited number	18
protein kinases	18
pulmonary artery	18
enzymatic activity	18
pharmaceutical sciences	18
therapeutic approach	18
per se	18
also reduced	18
positively charged	18
response elicited	18
induced il	18
plasma il	18
ebola infection	18
fever vaccine	18
decision making	18
brain research	18
human vaccines	18
scientific research	18
activated receptor	18
see ch	18
visual information	18
identifi cation	18
clinical disease	18
cancer vaccines	17
mrna level	17
vaccine platform	17
surface charge	17
th type	17
vesicular stomatitis	17
pupil size	17
mechanical ventilation	17
biological activities	17
japan science	17
jurkat cells	17
sentiment system	17
human blood	17
one example	17
experimental model	17
light stimulus	17
therapeutic efficacy	17
tissue factor	17
also significantly	17
induced colitis	17
activated cd	17
hla alleles	17
increased significantly	17
among different	17
hemorrhagic fever	17
critical illness	17
may involve	17
local inflammatory	17
circumsporozoite protein	17
different levels	17
proteolytic activity	17
protein boost	17
receptor binding	17
study examined	17
presynaptic terminals	17
ii score	17
intramuscular injection	17
restricted ctl	17
cells derived	17
regression analysis	17
protect mice	17
embryonic development	17
human genome	17
climate change	17
air pollution	17
fusion proteins	17
primary immune	17
vaccine approaches	17
disease models	17
granule cell	17
rational design	17
natural hazards	17
human studies	17
profi le	17
vgamma vdelta	17
cytoplasmic domain	17
intracellular dna	17
recent progress	17
study investigated	17
morphological changes	17
elderly population	17
cell lysates	17
fmri study	17
late phase	17
labeled cells	17
antiviral activity	17
cell viability	17
normal human	17
lung inflammation	17
deleterious effects	17
host immunity	17
umbilical cord	17
expression system	17
type iii	17
nude mice	17
dna complexes	17
cell count	17
scid mice	17
interface habits	17
specific ige	17
shed blood	17
adjuvanted vaccines	17
specific ifn	17
extensively studied	17
nucleocapsid protein	17
vice versa	17
nasal secretions	17
potential vaccine	17
pathological conditions	17
therapeutic vaccine	17
culture system	17
reporter gene	17
immunological synapse	17
expression data	17
infl ammation	17
septic response	17
joint inflammation	17
like protease	17
activated macrophages	17
motor cortex	17
physiological sciences	17
central government	17
study revealed	17
ec ii	17
regulated genes	17
chain fatty	17
respiratory epithelial	17
respiratory pathogens	17
physiological role	17
cd clones	17
lymphocyte activation	17
critical care	17
rem sleep	17
influencing infectious	17
tokyo medical	17
mice deficient	17
oxygen radicals	17
regulatory role	17
glutamate receptors	17
transfected cells	17
cell stimulation	17
weeks post	17
potent anti	17
immune control	17
vaccine research	17
gene regulation	17
nasal epithelial	17
digital media	17
mpxv infection	17
data obtained	17
also detected	17
acid sequence	17
pam csk	16
patients compared	16
inflammatory stress	16
causative agent	16
second messenger	16
ulcerative colitis	16
cells expressed	16
protein vaccine	16
safety concerns	16
income countries	16
analysis demonstrated	16
pathogen interactions	16
cell technologies	16
therapeutic strategies	16
high mortality	16
intracellular pathogen	16
clinical features	16
national institutes	16
cell number	16
surgical trauma	16
factor receptor	16
mucosal surface	16
sensitive dye	16
initial response	16
adult rat	16
serum cytokine	16
reserve capacity	16
partial protection	16
programmed cell	16
amplifying rna	16
generally accepted	16
experimental infection	16
applied biosystems	16
peritoneal cavity	16
acquired pneumonia	16
target antigen	16
like il	16
infrared spectroscopy	16
thyroid hormone	16
superoxide dismutase	16
ms disease	16
core aa	16
macrophage inflammatory	16
wildtype mice	16
important implications	16
strongly suggest	16
induced tnf	16
recombinant dna	16
binding lectin	16
viral epitopes	16
axon guidance	16
oxygen saturation	16
eye movement	16
tight junctions	16
liver injury	16
nod mice	16
pulmonary fibrosis	16
diseases like	16
infectious hematopoietic	16
still unknown	16
cd positive	16
nadph oxidase	16
antibody titer	16
cytokine genes	16
habit formation	16
also identified	16
expressing cd	16
next generation	16
recently developed	16
elevated expression	16
chronic infection	16
intracellular ca	16
receptive fields	16
studies demonstrate	16
immunomodulatory properties	16
asthma control	16
data analysis	16
cortical areas	16
neural progenitor	16
group ii	16
da neurons	16
health behaviors	16
also occur	16
niigata university	16
cell priming	16
precursor cells	16
obstructive pulmonary	16
legionella pneumophila	16
kg i	16
polymeric nanoparticles	16
intraperitoneal injection	16
stimulated genes	16
plasminogen activator	16
study suggests	16
stomatitis virus	16
treated group	16
flow cytometric	16
existing studies	16
rat hippocampus	16
analysis indicated	16
one week	16
information regarding	16
targeted delivery	16
eye movements	16
glutamic acid	16
cellular uptake	16
high doses	16
steady state	16
capsid protein	16
allergic airway	16
system may	16
life sci	16
plasma endotoxin	16
dependent innate	16
functional significance	16
human monoclonal	16
statistical significance	16
inflammatory effect	16
hematopoietic necrosis	16
boost regimen	16
human leukocyte	16
risk assessment	16
well defined	16
biological effects	16
mice using	16
pulmonary hypertension	16
two days	16
individual differences	16
regulatory mechanisms	16
lethal challenge	16
higher expression	16
sin nombre	16
effective treatment	16
responses elicited	16
il il	16
fine specificity	16
network analysis	16
per day	16
intracellular bacteria	16
antigen discovery	16
specific manner	16
might also	16
nuclear knowledge	16
among others	16
cells isolated	16
whole body	16
th day	16
attenuated vaccine	16
provide new	16
intestinal epithelial	16
different aspects	15
pcr analysis	15
response following	15
cognitive function	15
neural development	15
functional roles	15
several types	15
will lead	15
iav infection	15
sting function	15
insulin sensitivity	15
terrorist attack	15
cell clone	15
new approach	15
markedly reduced	15
long time	15
modified live	15
regulatory proteins	15
bacterial lipopolysaccharide	15
will allow	15
serum albumin	15
cells specific	15
will focus	15
kyushu institute	15
bacterial growth	15
treated patients	15
virus strains	15
induced production	15
terminal region	15
health authorities	15
total body	15
presenting cell	15
labile toxin	15
tightly regulated	15
current response	15
colon cancer	15
attenuated live	15
observations suggest	15
negative effects	15
firing rate	15
following trauma	15
data provide	15
markedly increased	15
also affect	15
iron oxide	15
inflammatory genes	15
patients received	15
significant improvement	15
inflammatory disorders	15
brain sci	15
virulent rv	15
low molecular	15
feedback loop	15
vast majority	15
disease prevention	15
lesser extent	15
vascular endothelial	15
negative feedback	15
barrier integrity	15
synthetic peptide	15
phase response	15
small interfering	15
west african	15
cell interactions	15
also tested	15
intestinal inflammation	15
therapeutic intervention	15
tnf levels	15
case study	15
active immunity	15
clinical efficacy	15
transcriptional activity	15
different strategies	15
host antiviral	15
early response	15
within days	15
wellness response	15
cord injury	15
response activities	15
conventional vaccines	15
breast milk	15
mesoporous silica	15
comparative analysis	15
bacterial pathogens	15
enhanced immunogenicity	15
molecular signatures	15
quantitative analysis	15
toxoplasma gondii	15
past decade	15
extremely low	15
hpa axis	15
two hours	15
frontal cortex	15
mitochondrial dna	15
perceived vulnerability	15
rotavirus infection	15
calcium influx	15
specific responses	15
proinfl ammatory	15
effector function	15
hematopoietic stem	15
different pathogens	15
one year	15
nasal vaccine	15
significantly correlated	15
also play	15
developed countries	15
specific monoclonal	15
cytokine receptors	15
potent immune	15
coupled receptors	15
plasma samples	15
platelet aggregation	15
response team	15
present data	15
immune defense	15
care workers	15
septic complications	15
suppressor cells	15
newly emerging	15
synapse formation	15
domain knowledge	15
receptor complex	15
negative selection	15
three major	15
oleic acid	15
hepatitis virus	15
pediatric sepsis	15
disease pathogenesis	15
financial support	15
live vaccines	15
increased cd	15
related diseases	15
spatial frequency	15
human nasal	15
recently demonstrated	15
culture supernatants	15
present results	15
particularly important	15
four different	15
infected host	15
medical care	15
cerebellar cortex	15
gold nanoparticle	15
clinical use	15
health services	15
informed consent	15
mice revealed	15
visual stimuli	15
vaccine components	15
vaccine carrier	15
genetic susceptibility	15
patients receiving	15
mpo activity	15
pulmonary syndrome	15
neuronal damage	15
mucosal sites	15
direct interaction	15
respiratory infection	15
treatment group	15
cerebral malaria	15
adjuvanted vaccine	15
previously demonstrated	15
many years	15
adult respiratory	15
generation model	15
human lung	15
interacting protein	15
control cells	15
sepsis may	15
potential role	15
three types	15
tract infections	15
linolenic acid	15
ifn therapy	15
type hypersensitivity	15
city university	15
bordetella pertussis	15
mg dl	15
law enforcement	15
tyrosine kinases	15
quantitative rt	15
i ii	15
optical imaging	15
protein antigen	15
fold higher	15
rotavirus vaccine	14
ii clinical	14
viral genes	14
functional role	14
knowledge embedding	14
identify novel	14
medial prefrontal	14
granulocyte colony	14
combination therapy	14
chronic viral	14
gray matter	14
also examined	14
baseline values	14
clinical evaluation	14
negative bacterial	14
soluble form	14
expression studies	14
cohesive subgroups	14
modern vaccines	14
also expressed	14
high expression	14
low concentrations	14
like structures	14
rna sequencing	14
deficient cells	14
prominent role	14
envelope protein	14
primary response	14
significantly associated	14
well described	14
vaccines currently	14
beta i	14
fluorescence microscopy	14
hokkaido university	14
protective antibody	14
examined using	14
terrorist attacks	14
inflammatory agents	14
bovine serum	14
clinical manifestations	14
two studies	14
suppressive effect	14
viral dna	14
crp levels	14
critical period	14
recent findings	14
significantly larger	14
glutamate transporters	14
coli heat	14
kir dl	14
may become	14
nucleotide sequence	14
blood stream	14
diseases including	14
common cause	14
dependent protein	14
aluminum hydroxide	14
studied using	14
initiation factor	14
superoxide production	14
per group	14
transcriptional activation	14
hematopoietic cells	14
likely due	14
sciatic nerve	14
insulin insensitivity	14
cell lineage	14
also provide	14
significantly improved	14
ifn treatment	14
prime boost	14
positive neurons	14
factors involved	14
signifi cant	14
primary visual	14
inflammatory markers	14
bacterial toxins	14
adherent cells	14
hla molecules	14
lung epithelial	14
group showed	14
social isolation	14
kinase activity	14
developmental stages	14
cmv infection	14
dna binding	14
vaccination strategy	14
assay using	14
increased il	14
patients may	14
higher antibody	14
mitochondrial membrane	14
firing patterns	14
health threats	14
serum concentrations	14
injury severity	14
mice primed	14
patients showed	14
soluble antigen	14
gut barrier	14
using two	14
accessory cells	14
signaling cascade	14
risk reduction	14
selective pressure	14
antioxidant defenses	14
transplant recipients	14
barrel cortex	14
visual field	14
using whole	14
late stages	14
term responses	14
see also	14
tumor development	14
response efficacy	14
estrogen receptor	14
rats subjected	14
normal controls	14
human populations	14
cells within	14
phase protein	14
kg bw	14
elderly subjects	14
stranded dna	14
tyrosine hydroxylase	14
lysosomal enzymes	14
specific anti	14
viral antigen	14
nlrp inflammasome	14
vaccine strains	14
using different	14
adenovirus vectors	14
general hospital	14
flow diagram	14
association study	14
tokyo university	14
mediated activation	14
memory formation	14
genital tract	14
structural changes	14
cell dependent	14
prime minister	14
various pathogens	14
neural mechanisms	14
pig model	14
among patients	14
accumulating evidence	14
natural history	14
cytosolic sensing	14
linear ubiquitin	14
ammatory response	14
antibiotic treatment	14
cd memory	14
igg levels	14
structural protein	14
strongly associated	14
lymphatic system	14
oxygen free	14
helper type	14
intradermal vaccination	14
canine parvovirus	14
interferon regulatory	14
acid changes	14
total number	14
retinal ganglion	14
also contribute	14
emerging viral	14
ns protein	14
dawley rats	14
case studies	14
oxidative damage	14
might play	14
orthopaedic trauma	14
blood monocytes	14
protective response	14
leading cause	14
locus coeruleus	14
significantly greater	14
intracellular signaling	14
ca signals	14
large quantities	14
technology agency	14
social support	14
endotoxin levels	14
lps administration	14
inactivated vaccines	14
cyclic di	14
inflammatory protein	14
glutamate release	14
derived neurotrophic	14
protective responses	14
memory cd	14
i receptor	14
genetic immunization	14
powerful tool	14
inner ear	14
cultured hippocampal	14
i cells	14
respiratory viral	14
i molecule	14
disaster relief	14
cd ctl	14
contact tracing	14
peptides corresponding	14
antigenic peptide	14
immune modulation	14
functional analysis	14
leukocyte antigen	14
postsynaptic currents	14
attenuated virus	14
model antigen	14
prevent infection	14
may serve	14
disease resistance	14
evasion strategies	14
crohns disease	14
cardiac index	14
embryonic day	14
cell antigen	14
prospective study	14
trained immunity	14
vascular smooth	14
respiratory burst	14
immune signaling	14
nucleotide polymorphisms	14
clinical data	14
cellular processes	14
conjugate vaccines	14
virus infected	14
effective mucosal	14
mediated apoptosis	14
activity may	13
following injury	13
adoptively transferred	13
cell division	13
cd lymphocytes	13
mycobacterium bovis	13
veterinary vaccines	13
postoperative day	13
virus ns	13
supply chain	13
additional studies	13
state university	13
public opinion	13
expressed cd	13
also express	13
develop new	13
sublingual immunization	13
matching relationship	13
immunosuppressive effects	13
antibody titres	13
genes related	13
host gene	13
current study	13
effector mechanisms	13
ca influx	13
contact system	13
immunological responses	13
oxygen consumption	13
dental university	13
potent inhibitor	13
also enhanced	13
mice vaccinated	13
coagulation cascade	13
i production	13
cellular mechanisms	13
extracellular signal	13
group received	13
moral foundations	13
induce immune	13
protective antigens	13
adenylate cyclase	13
cultured cells	13
viral quasispecies	13
also demonstrated	13
immune memory	13
immune dysfunction	13
proposed model	13
double blind	13
negative regulation	13
genetic material	13
studies suggested	13
promoter regions	13
coronavirus replication	13
public crises	13
i trial	13
cell expansion	13
experiments using	13
higher concentrations	13
virus may	13
first week	13
possible mechanism	13
neutrophil recruitment	13
study provides	13
conformational change	13
controlled release	13
system dynamics	13
severe cases	13
antigenic variation	13
infected macrophages	13
goblet cells	13
first two	13
days following	13
may allow	13
vaccine group	13
basic protein	13
inactivated virus	13
behavioral abnormalities	13
present antigen	13