Questions

This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.

identifier question
cord-102920-z5q3wo7vInsight from ACE2-S- Protein Interactions Middle East respiratory syndrome coronavirus( MERS- CoV): animal to human interaction MERS- CoV: the intermediate host identified?
cord-253438-k8iqv1jbA novel coronavirus from patients with pneumonia in China Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Are pangolins the intermediate host of the 2019 novel coronavirus( SARS- CoV-2)?
cord-183197-dxmto1tuIn Healthcare Workers with Ongoing High Risk Exposure to COVID-19 Prophylaxis with tetracyclines in ards: Potential therapy for covid-19-induced ards?
cord-276493-hoaxv5e0a casepopulation study Anti- HCV, nucleotide inhibitors, repurposing against COVID-19 Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?
cord-252919-647zcjguNL63: a clinically important virus?
cord-281005-6gi18vkaWhy are RNA virus mutation rates so damn high?
cord-296657-mymndjvdWhy are RNA virus mutation rates so damn high?
cord-256156-mywhe6w9How good is automated protein docking?
cord-256156-mywhe6w9True Receptors or Adaptation Bias?
cord-262043-66qle52abioRxiv Is it reliable to use common molecular docking methods for comparing the binding affinities of enantiomer pairs for their protein target?
cord-262043-66qle52aprotein Are scoring functions in protein Àprotein docking ready to predict interactomes?
cord-275185-9br8lwmaThe effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta- analysis Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A( H1N1) 2009 virus infection Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience Clinical characteristics of 26 human cases of highly pathogenic avian influenza A( H5N1) virus infection in China Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea Treatment of 5 critically Ill patients With COVID-19 with convalescent plasma Effectiveness of convalescent plasma therapy in severe COVID-19 patients Treatment with convalescent plasma for critically Ill patients with SARS- CoV-2 infection Treatment with convalescent plasma for COVID-19 patients in Wuhan Use of convalescent plasma therapy in two COVID-19 patients with acute respiratory distress syndrome in Korea clinicalmanagement- of- severe- acute- respiratory- infection- when- novel- coronavirus-(ncov)-infection- is- suspected Guideline for diagnosis and treatment for novel coronavirus pneumonia Establishment and validation of a pseudovirus neutralization assay for SARS- CoV-2 Meta- analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment?
cord-275185-9br8lwmawhy and how?
cord-263167-es806qhzWhat do our results suggest for SARS- CoV-2 vaccine design?
cord-319590-f9qcabcx: What Are the Next Steps?
cord-309411-2dfiwo65What are the implications of this transition state found in CoV1 but not in CoV2 at neutral pH?
cord-263090-29n9tsk9Identifying SARS- CoV-2 related coronaviruses in Malayan pangolins Structure, Function, and Evolution of Coronavirus Spike Proteins Cryo- EM structure of the 2019-nCoV spike in the prefusion conformation Structure, Function, and Antigenicity of the SARS- CoV-2 Spike Glycoprotein Structural basis for the recognition of SARS- CoV-2 by full- length human ACE2 Cryo- electron microscopy structures of the SARS- CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding The 3.1-Angstrom Cryo- electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion Conformation Cryo- EM structures of MERS- CoV and SARS- CoV spike glycoproteins reveal the dynamic receptor binding domains SARS- CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor A highly conserved cryptic epitope in the receptor- binding domains of SARS- CoV-2 and SARS- CoV Topological and energetic factors: what determines the structural details of the transition state ensemble and"en- route"intermediates for protein folding?
cord-263090-29n9tsk9Identifying SARS- CoV-2 related coronaviruses in Malayan pangolins Structure, Function, and Evolution of Coronavirus Spike Proteins Cryo- EM structure of the 2019-nCoV spike in the prefusion conformation Structure, Function, and Antigenicity of the SARS- CoV-2 Spike Glycoprotein Structural basis for the recognition of SARS- CoV-2 by full- length human ACE2 Cryo- electron microscopy structures of the SARS- CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding The 3.1-Angstrom Cryo- electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion Conformation Cryo- EM structures of MERS- CoV and SARS- CoV spike glycoproteins reveal the dynamic receptor binding domains SARS- CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor A highly conserved cryptic epitope in the receptor- binding domains of SARS- CoV-2 and SARS- CoV Topological and energetic factors: what determines the structural details of the transition state ensemble and"en- route"intermediates for protein folding?
cord-280941-ds6x0yymHow will HPV vaccines affect cervical cancer?
cord-280941-ds6x0yymThe composition and the structure of bacterioferritin of Escherichia coli Self- assembly in the ferritin nano- cage protein superfamily Presenting native- like trimeric HIV-1 antigens with self- assembling nanoparticles Hemagglutinin- stem nanoparticles generate heterosubtypic influenza protection Ferritin nanocages: great potential as clinically translatable drug delivery vehicles?
cord-305742-wf6qxplfWhat is Life?
cord-291420-40xsypztCan we gain valuable insights regarding RBD- ACE2 interface formation by analyzing these mutations?
cord-291420-40xsypztWhat are the mutations acquired on RBD during COVID-19 and what are the interfacial molecular rearrangements induced by these mutations?
cord-310230-9wfb43gtEnhanced Receptor Binding of SARS- CoV-2 through Networks of Hydrogen- Bonding and Hydrophobic Interactions Is the Rigidity of SARS- CoV-2 Spike Receptor- Binding Motif the Hallmark for Its Enhanced Infectivity?
cord-310230-9wfb43gtInsights from All- Atom Simulations Characterization of the Receptor- Binding Domain( RBD) of 2019 Novel Coronavirus: Implication for Development of RBD Protein as a Viral Attachment Inhibitor and Vaccine Structural and Functional Basis of SARS- CoV-2 Entry by Using Human ACE2 Phylogenetic Network Analysis of SARS- CoV-2 Genomes Is the Rigidity of SARS- CoV-2 Spike Receptor- Binding Motif the Hallmark for Its Enhanced Infectivity?
cord-290290-wyx9ib7sgp120 Interactions with alpha4beta7 Structure, Function, and Antigenicity of the SARS- CoV-2 Spike Glycoprotein Testing for responses to the wrong SARS- CoV-2 antigen?
cord-287205-k64svq6nWill COVID-19 538 become the next neglected tropical disease?
cord-285900-3rr0j5tkHow can we quantitatively evaluate the epitopes'neutralizing immunogenicity?
cord-329392-fufattj8medRxiv The role of antibody testing for SARS- CoV-2: is there one?
cord-281793-tj4m01s4Could such antibodies be cross- reactive with other SARS- related CoVs( SARSr- CoVs)?
cord-281793-tj4m01s4Could such cross- reactive antibodies have neutralizing activities for all SARSr- CoVs?
cord-281793-tj4m01s4What would be ideal targets or epitopes for cross- neutralizing antibodies?
cord-267001-csgmc155The adjuvant GLA- SE promotes human Tfh cell expansion and emergence of public TCRbeta clonotypes Can follicular helper T cells be targeted to improve vaccine efficacy?
cord-267001-csgmc155Where is the cut- off?
cord-296187-nnv2e7grA small molecule- kinase interaction map for clinical kinase inhibitors Molecular therapeutics: is one promiscuous drug against multiple targets better than combinations of molecule- specific drugs?
cord-332134-88wfcc3yHow good are my data and what is the resolution?
cord-309898-sju15hevRecent insights into emerging coronaviruses Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia MERS in South Korea and China: A potential outbreak threat?
cord-309898-sju15hevSARS- CoV-2 Have Arisen via Serial Passage through an Animal Host or Cell Culture?:
cord-265697-bbvlowyoanimal to human interaction MERS- CoV: the intermediate host identified?
cord-332185-a96r1k7a437 pangolins Isolation of SARS- CoV-2-related coronavirus from Malayan 439 pangolins Are pangolins the intermediate host of the 2019 novel 441 coronavirus( SARS- CoV-2)?
cord-339093-mwxkvwazEngineered Autonomous Human Variable Domains Antiviral Monoclonal Antibodies: Can They Be More Than Simple Neutralizing Agents?
cord-291790-z5rwznmvWhich Genetic 594 Mutations Are Antigenically Important?
cord-291790-z5rwznmvWhy are RNA virus mutation rates so damn high?
cord-336150-l8w7xk0bhospitalists'perspective Broad- spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Coronavirus: epidemiology, genome replication and the interactions with their hosts Characterization of the receptorbinding domain( RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine Differential stepwise evolution of SARS coronavirus functional proteins in different host species Dexamethasone for COVID-19?
cord-333089-ufyzqgqkCirculating plasma concentrations of angiotensin- converting enzyme 2 in men and women with heart failure and effects of renin- angiotensin- aldosterone inhibitors Predictors of mortality in hospitalized COVID-19 patients: a systematic review and meta- analysis Impact of sex and gender on COVID-19 outcomes in Europe Are sex discordant outcomes in COVID-19 related to sex hormones?
cord-328189-jpkxjn6eThis comparison raises the following question: How does SARS-2002 RBD reach an ACE2 binding affinity that is comparable to that of COVID-19 but with fewer contact pairs and a smaller interface area?
cord-339724-roj8ksvcthe beginning of another SARS- like pandemic?
cord-319855-78xmxymuAre sufficient details of methods and analysis provided to allow replication by others?
cord-319855-78xmxymuYes Are all the source data underlying the results available to ensure full reproducibility?
cord-353748-y1a52z8eBacteriocins-a viable alternative to antibiotics?
cord-332855-u0amf1ohThe rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site Unique carbohydrate- carbohydrate interactions are required for high affinity binding between Fc ␥ RIII and antibodies lacking core fucose Model system for cell adhesion mediated by weak carbohydrate- carbohydrate interactions Carbohydrate- carbohydrate interaction as a major force initiating cell- cell recognition Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate- carbohydrate interactions Are Lewis b and H type 1 on Helicobacter pylori involved in binding of bacteria to MUC1 mucin?
cord-347587-auook38yMolecular evolution of MERS coronavirus: dromedaries as a recent intermediate host or longtime animal reservoir?
cord-354868-pqn59ojjThe protein complex crystallography beamline( BL19U1) at the Shanghai 545 Synchrotron Radiation Facility How good are my data and what is the resolution?
cord-328003-yovp8squWhat Are the Most Powerful Immunogen Design Vaccine Strategies?
cord-328003-yovp8squWhat Are the Most Powerful Immunogen Design Vaccine Strategies?
cord-355807-q3bngari: Where are we?
cord-295482-qffg6r91What can we predict about viral evolution and emergence?
cord-352527-eeyqh9ncthe beginning of another SARS- like pandemic?
cord-338538-uea9kwgeA structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine Bioengineering bacterial outer membrane vesicles as vaccine platform Bacterial outer membrane vesicles: New insights and applications Meningococcal serogroup B vaccines: Will they live up to expectations?
cord-353161-mtq6yh25Can structural modeling predict cross- species transmission of SARS- CoV-2?
cord-353161-mtq6yh25Ready To Predict Interactomes?
cord-321918-9jwma2y6Human monoclonal antibodies block the binding of SARS- CoV-2 spike protein to angiotensin converting enzyme 2 receptor A human monoclonal antibody blocking SARS- CoV-2 infection Rapid selection of a human monoclonal antibody that potently neutralizes SARS- CoV-2 in two animal models Therapeutic potential of small molecules and engineered proteins What are the drugs of the future?
cord-321918-9jwma2y6Prim Care Meta- analysis: convalescent blood products for spanish influenza pneumonia: a future h5n1 treatment?
cord-321918-9jwma2y6Targeting membrane- bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the Middle East respiratory syndrome virus Angiotensin- converting enzyme 2: cardioprotective player in the renin- angiotensin system?
cord-333703-1ku3jc9sThe Heart in COVID-19: Primary Target or Secondary Bystander?
cord-333703-1ku3jc9sdifferent from other PVOD?
cord-332948-h297ukuuCan We Rely on Computational Predictions To Correctly Identify Ligand Binding Sites on Novel Protein Drug Targets?
cord-332948-h297ukuur o o f resolution silico assessment of potential druggable pockets on the surface of??
cord-332948-h297ukuur o o f resolution silico assessment of potential druggable pockets on the surface of??
cord-340960-abanr641182 pediatric COVID-19 patients with different severities and allergic status Blood Myeloperoxidase- DNA, a biomarker of early response to SARS- CoV-2 infection?
cord-340960-abanr641Allergy Clinical characteristics of 140 patients infected with SARS- CoV-2 in Wuhan Is global BCG vaccination- induced trained immunity relevant to the progression of SARS- CoV-2 pandemic?
cord-340960-abanr641do we know so far?
cord-338517-1mxcssjj( H1N1) 2009 virus infection Read in the Section on Diseases of Children, at the Forty- fourth Annual Meeting of the American Medical Association Meta- Analysis: Convalescent Blood Products for Spanish Influenza Pneumonia: A Future H5N1 Treatment?
cord-338517-1mxcssjjA possible role for B cells in COVID-19?:
cord-338517-1mxcssjjCould Intravenous Immunoglobulin Collected from Recovered Coronavirus Patients Protect against COVID-19 and Strengthen the Immune System of New Patients?
cord-338517-1mxcssjjIs COVID-19 receiving ADE from other coronaviruses?