trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
as well as	3235
the presence of	2453
in order to	1794
one of the	1593
the development of	1485
the role of	1392
the use of	1295
of the protein	1290
in this study	1236
based on the	1232
the expression of	1218
severe acute respiratory	1204
acute respiratory syndrome	1186
the formation of	1182
in the presence	1116
due to the	1054
it has been	1050
the effect of	1034
structure of the	1017
involved in the	991
been shown to	990
analysis of the	989
the number of	970
a number of	919
respiratory syndrome coronavirus	894
in addition to	843
has been shown	828
found to be	817
the production of	797
role in the	779
can be used	750
the absence of	734
the effects of	729
the plasma membrane	694
according to the	685
hepatitis c virus	685
in response to	668
was used to	666
the case of	647
a variety of	647
on the other	640
of the sars	638
expression of the	629
is required for	626
part of the	618
was found to	613
the identification of	606
such as the	601
the other hand	600
the present study	598
of the viral	593
in the case	591
of the human	587
the regulation of	587
to determine the	585
to investigate the	585
in the absence	583
shown to be	571
compared to the	570
the aim of	566
the structure of	557
of the virus	551
be used to	550
the cell surface	546
we found that	545
associated with the	538
in terms of	537
the surface of	537
an important role	536
changes in the	535
are involved in	533
the treatment of	531
in patients with	525
the level of	524
in the present	517
a role in	516
of the most	515
the synthesis of	514
well as the	512
to be a	507
the activity of	493
is involved in	492
the activation of	490
proteins in the	488
the binding of	487
important role in	486
in vitro and	482
amino acid residues	482
the function of	481
the fact that	479
is one of	477
the ability of	476
the endoplasmic reticulum	476
is associated with	468
be involved in	460
of the s	458
the host cell	457
there is a	457
the interaction of	456
some of the	455
to study the	455
of this study	453
characterization of the	450
most of the	446
the mechanism of	446
the s protein	446
herpes simplex virus	444
as a result	443
showed that the	441
the amino acid	440
in contrast to	437
of the proteins	434
understanding of the	432
is essential for	430
activity of the	429
the importance of	429
human immunodeficiency virus	423
has also been	422
responsible for the	421
a series of	420
and characterization of	418
and in vivo	416
have shown that	412
activation of the	412
were used to	409
of the n	408
role of the	406
in which the	406
with respect to	405
the analysis of	403
members of the	402
of the two	401
related to the	400
present in the	398
cd t cells	397
amino acid sequence	397
this study was	397
the n protein	395
that can be	394
of a protein	394
of the cell	394
the spike protein	393
on the surface	392
region of the	389
were found to	386
function of the	386
in the cytoplasm	386
was shown to	384
the ability to	382
the majority of	382
study was to	381
has been reported	380
used as a	380
vitro and in	378
of amino acids	377
the results of	377
found in the	375
end of the	374
the basis of	374
were able to	371
properties of the	370
in the same	370
crystal structure of	369
are able to	365
the generation of	360
the context of	359
the amount of	356
to interact with	355
an increase in	355
by means of	353
as compared to	350
have been identified	349
of the membrane	348
of the host	348
have been shown	347
results suggest that	346
to that of	343
that of the	342
of severe acute	340
the pathogenesis of	339
contribute to the	338
was supported by	338
is based on	337
and in the	336
wide range of	336
the interaction between	335
the detection of	335
sequence of the	334
in this work	334
a total of	334
depending on the	331
the induction of	331
domain of the	330
influenza a virus	329
it is possible	329
for the development	327
the study of	326
suggest that the	326
of these proteins	326
is able to	326
in the regulation	326
was carried out	324
in the context	324
for the treatment	322
has not been	321
the process of	321
aim of this	321
the release of	318
components of the	318
used for the	318
a set of	318
the design of	318
on the basis	317
a wide range	316
appears to be	316
the end of	315
the lack of	315
to the cell	313
the control of	313
derived from the	312
required for the	310
of a novel	308
hepatitis b virus	307
the influence of	307
a combination of	307
we show that	306
is the most	306
this work was	305
in the nucleus	304
to be the	303
each of the	303
to evaluate the	302
binding to the	302
at the same	302
the addition of	301
at room temperature	301
supported by the	301
found that the	301
known to be	300
there is no	299
in combination with	298
in the development	298
of amino acid	297
member of the	297
have also been	296
are known to	296
proteins involved in	296
play a role	295
the m protein	294
increase in the	294
a and b	294
formation of the	294
the inhibition of	291
amino acid composition	291
central nervous system	290
which can be	289
used in the	288
show that the	287
is known to	287
interaction with the	287
it is not	286
was used as	286
protein in the	285
the levels of	285
large number of	283
is responsible for	283
because of the	283
as shown in	282
to identify the	281
be used as	281
the golgi apparatus	279
to understand the	279
be used for	278
have been reported	278
in the cell	278
infectious bronchitis virus	277
is mediated by	276
a result of	276
the immune system	275
have been used	275
a range of	274
seems to be	271
proteins that are	268
the existence of	267
regulation of the	267
is an important	267
in mammalian cells	266
revealed that the	266
surface of the	265
of the peptide	265
results indicate that	264
shown in fig	263
been used to	263
can also be	262
proteins of the	262
we investigated the	262
the rate of	261
similar to the	259
located in the	258
and can be	258
presence of the	257
shown that the	256
consistent with the	256
been shown that	255
the severe acute	255
all of the	255
in escherichia coli	255
resulted in a	254
observed in the	254
for the first	253
the cells were	252
has been used	252
well as in	251
cells in the	251
which is a	250
been reported to	249
was determined by	249
structure and function	248
immunodeficiency virus type	248
for min at	248
nature of the	248
binding of the	248
identification of a	247
have been developed	246
the application of	246
the immune response	245
leading to the	245
the same time	245
the stability of	245
the active site	245
of the disease	244
mutations in the	244
are associated with	244
identification of the	244
it can be	244
cd and cd	243
porcine epidemic diarrhea	242
the sars coronavirus	242
a large number	241
in infected cells	241
middle east respiratory	241
that have been	241
their ability to	241
the discovery of	241
east respiratory syndrome	240
effect on the	240
of the target	239
in the brain	239
was used for	239
addition to the	239
results showed that	239
of the c	237
due to their	236
led to the	236
was observed in	235
the impact of	235
play an important	235
also known as	235
to be involved	235
of the spike	235
in the human	234
of patients with	233
demonstrated that the	233
inhibition of the	233
and function of	232
our understanding of	231
in the er	231
leads to the	231
insights into the	231
residues in the	231
the first time	231
the most common	230
presence of a	230
in comparison to	230
data suggest that	230
interact with the	230
was performed using	229
acts as a	229
effect of the	229
of the same	228
suggesting that the	227
differences in the	227
amino acid sequences	227
binds to the	226
characterization of a	225
is important for	225
a member of	225
data not shown	225
the accumulation of	225
the course of	224
interacts with the	224
mouse hepatitis virus	223
for h at	223
western blot analysis	223
of viral proteins	223
based on a	222
are required for	222
heat shock protein	222
due to its	222
has been proposed	221
molecular dynamics simulations	220
different types of	220
results show that	220
reactive oxygen species	219
a role for	219
respiratory syncytial virus	218
of the p	218
for the production	218
cells infected with	218
of the enzyme	217
development of a	217
between the two	217
work was supported	217
associated with a	216
of the three	215
of the major	215
and it is	214
the site of	214
dependent on the	214
similar to that	213
depends on the	213
interaction between the	212
the involvement of	212
of the coronavirus	212
stability of the	212
to assess the	212
suggests that the	211
compared with the	211
is thought to	211
it is a	211
that it is	210
the concentration of	210
likely to be	210
in the formation	210
the possibility of	210
interaction of the	209
insight into the	209
open reading frame	209
structural and functional	209
high levels of	208
amino acids in	207
structure of a	207
is characterized by	207
in some cases	207
essential for the	206
the target protein	206
when compared to	206
vesicular stomatitis virus	206
the most important	206
protein of sars	206
is important to	205
this is the	205
plays an important	205
to increase the	204
detected in the	204
component of the	204
the secretory pathway	204
in the protein	204
shown in figure	204
were treated with	203
epidemic diarrhea virus	203
formation of a	203
the viral genome	203
appear to be	203
mechanism of action	203
proteins have been	202
to improve the	202
it was found	202
results in the	202
in the host	201
the assembly of	200
than that of	200
in the first	200
by western blot	200
protein is a	199
study of the	199
the central nervous	199
have not been	198
of proteins in	198
proteomic analysis of	198
a key role	197
were used for	197
in the pathogenesis	197
need to be	197
mhc class i	197
proteins such as	196
it is also	196
s and s	195
the replication of	195
on the cell	195
it is important	195
regions of the	194
could be used	194
be associated with	194
were shown to	194
of a single	194
has been suggested	194
to play a	193
it was shown	193
localization of the	193
has been demonstrated	193
the degree of	193
were isolated from	192
in the s	192
the size of	192
the nature of	192
have been described	192
comparison of the	191
effects of the	191
indicate that the	191
of the genome	191
of the immune	191
studies on the	191
is the first	190
serve as a	190
is composed of	189
of the fusion	189
of the first	189
at the end	188
the innate immune	188
of this protein	187
many of the	187
be due to	187
expression of a	187
but not in	187
to bind to	187
of the m	187
is used to	186
mediated by the	186
key role in	186
are shown in	186
were analyzed by	186
the in vitro	185
are essential for	185
protein of the	184
in this context	184
some of these	184
a decrease in	184
was confirmed by	184
coronavirus nucleocapsid protein	183
of the amino	183
expressed in the	183
these results suggest	183
be used in	183
added to the	182
control of the	182
remains to be	182
the potential of	182
as a consequence	181
to form a	181
bind to the	181
referred to as	181
the range of	181
considered to be	180
is dependent on	180
the molecular mechanisms	180
may be a	179
will be discussed	179
suggested that the	179
were used as	179
of hepatitis c	179
were carried out	179
were determined by	179
size of the	178
been found to	178
was added to	178
is a major	178
indicated that the	178
encoded by the	177
is consistent with	177
in recent years	177
may contribute to	177
is that the	177
of recombinant proteins	177
thought to be	176
was found that	176
the crystal structure	176
could not be	176
the degradation of	176
at least one	175
together with the	175
in the field	174
a group of	174
as in the	174
the nucleocapsid protein	174
proteins can be	174
a crucial role	173
in the treatment	173
be able to	173
structures of the	173
the golgi complex	173
in the golgi	172
out of the	172
the e protein	172
to analyze the	172
the loss of	172
identified in the	172
it should be	172
in this case	172
the need for	171
the mechanisms of	171
are responsible for	171
a family of	171
use of the	170
bound to the	170
is likely to	170
coronavirus spike protein	170
we were able	170
reported to be	170
lead to the	170
has been found	170
in vivo and	170
can be found	170
is shown in	169
the prediction of	169
the sequence of	169
in case of	169
important for the	169
in the control	169
this study we	169
is due to	168
from patients with	168
by flow cytometry	168
followed by a	168
the potential to	168
the combination of	168
were subjected to	168
is known about	167
the cell membrane	167
the form of	167
in cell culture	167
that has been	166
can lead to	166
interactions between the	166
the result of	166
was able to	166
and in vitro	166
to the nucleus	165
innate immune response	165
are present in	165
as a model	165
protein and the	165
the protein is	165
as a potential	164
due to a	164
simplex virus type	164
is regulated by	164
to the plasma	164
amino acids and	164
information on the	164
is supported by	164
the binding site	164
there was no	164
that there is	164
obtained from the	163
p r o	163
and that the	163
o u r	163
of influenza a	162
to predict the	162
is present in	162
we conclude that	162
n a l	162
which is the	162
we have developed	162
l p r	161
p r e	161
we showed that	161
r o o	161
a l p	161
was shown that	161
j o u	161
of the er	161
u r n	161
of the golgi	161
r n a	161
of the binding	161
o o f	161
nsp and nsp	161
to elucidate the	160
of the e	160
the structure and	160
at the c	160
in our study	160
of influenza virus	160
the distribution of	160
we have shown	160
a function of	159
its ability to	159
determination of the	159
in agreement with	159
resulting in the	159
studies have shown	159
of membrane proteins	158
the purpose of	158
is possible to	158
by using a	158
the time of	158
better understanding of	158
we aimed to	157
the s subunit	157
from the er	157
has to be	157
the action of	157
expression levels of	157
to examine the	156
at the n	156
resulted in the	156
state of the	156
of the gene	155
the performance of	155
of the a	155
of action of	155
epidermal growth factor	155
will be presented	155
corresponding to the	155
terminus of the	155
we observed that	154
little is known	154
the er membrane	154
gene expression in	154
predicted to be	154
by mass spectrometry	154
to the golgi	154
proteins from the	154
to have a	154
in the membrane	154
semliki forest virus	154
the most abundant	154
site of the	154
is possible that	153
the secondary structure	153
results in a	153
in the early	153
isolated from the	153
for the detection	153
of sars coronavirus	153
in the future	153
cells of the	153
the extent of	152
in the form	152
and expression of	152
indicating that the	152
side of the	152
is necessary for	152
its role in	152
been implicated in	151
the lipid bilayer	151
length of the	151
for this purpose	151
the genome of	151
determined by the	150
have to be	150
terminal domain of	150
were incubated with	149
an in vitro	149
of a new	149
the efficiency of	149
protein data bank	148
to be used	148
development of the	148
its interaction with	147
is critical for	147
are the most	147
crucial role in	147
in the range	147
the evolution of	147
of the complex	147
in the viral	147
there was a	147
in the last	147
studies of the	147
of the present	147
this suggests that	147
leads to a	146
of which are	146
of gene expression	146
disruption of the	146
compared to control	146
linked to the	146
the kinetics of	146
type i interferon	146
that could be	146
of the receptor	146
change in the	145
be found in	145
the relationship between	145
in the past	145
form of the	145
of the molecular	145
assembly of the	145
of the different	145
these proteins are	145
is a key	145
respect to the	144
li et al	144
to determine whether	144
wang et al	144
the nucleus and	144
protein has been	144
to characterize the	143
the possibility that	143
the characterization of	143
act as a	143
at the time	143
the control group	142
to reduce the	142
the onset of	142
interactions with the	142
which in turn	142
features of the	142
materials and methods	142
structural basis for	142
the interaction with	142
in this review	142
the present work	142
a critical role	142
to develop a	142
analysis was performed	142
were obtained from	141
liu et al	141
one or more	141
at the cell	141
mouth disease virus	141
ability of the	141
of the cellular	140
the cell cycle	140
have been found	140
belongs to the	140
results of the	140
contrast to the	140
the recognition of	140
levels of the	140
in the literature	140
to the development	140
the viral rna	140
diseases such as	140
no effect on	140
of the cells	140
to the cytoplasm	140
majority of the	140
and has been	140
aim of the	140
cleavage of the	139
mechanism of the	139
be related to	139
to explore the	139
a subset of	139
attached to the	139
this study is	139
by using the	139
which has been	139
mechanism by which	139
the availability of	139
of proteins and	138
subcellular localization of	138
to be an	138
focused on the	138
it may be	138
the properties of	138
proteins to the	138
needs to be	138
has been described	138
the field of	138
to the formation	138
in the study	137
functions of the	137
of the interaction	137
the length of	137
to be more	137
a novel coronavirus	137
prediction of protein	137
we have used	136
viral replication and	136
in the process	136
may lead to	136
transmission electron microscopy	136
parts of the	136
has been identified	136
be responsible for	135
were detected in	135
in comparison with	135
it is known	135
in complex with	135
nanoparticle tracking analysis	135
the dynamics of	135
the interactions between	134
the efficacy of	134
growth factor receptor	134
by the presence	134
the wild type	134
sequences of the	134
composition of the	134
to the er	134
open reading frames	134
stages of the	134
for the identification	134
was performed by	134
for detection of	134
be considered as	133
is crucial for	133
are likely to	133
close to the	133
were found in	133
caused by the	133
at least two	133
in living cells	133
tumor necrosis factor	133
the changes in	133
the recruitment of	133
as described above	132
were observed in	132
of the peptides	132
in the central	132
of the total	132
with regard to	132
cancer cell lines	132
effects on the	132
nucleocapsid protein of	132
may not be	132
intrinsically disordered proteins	132
of viral rna	132
have demonstrated that	132
half of the	132
as a function	131
distribution of the	131
was assessed by	131
led to a	131
the frequency of	131
carried out by	131
of herpes simplex	131
is capable of	131
class i mhc	130
case of the	130
in the following	130
included in the	130
the host immune	130
of the drug	130
tandem mass spectrometry	130
in line with	130
the association of	130
the concept of	129
is caused by	129
in relation to	129
the amino acids	129
have been proposed	129
a consequence of	129
the observation that	129
any of the	129
which may be	129
immune response to	129
plays a role	129
used as the	129
as previously described	128
seem to be	128
use of a	128
of human immunodeficiency	128
used to determine	128
implicated in the	128
that the protein	128
dependent rna polymerase	128
of the dna	128
to inhibit the	128
unfolded protein response	128
and of the	128
more than one	127
similar to those	127
to those of	127
method for the	127
the quality of	127
used to identify	127
data indicate that	127
of infected cells	127
to the nucleolus	127
the growth of	127
to the protein	127
with the same	127
of the b	127
activity in the	127
and evolution of	127
the functions of	127
was to investigate	127
was found in	127
analysis of protein	126
none of the	126
of the influenza	126
a recent study	126
the introduction of	126
and analysis of	126
of the rna	126
of the recombinant	126
binding site of	126
as a novel	126
are important for	126
resulting in a	125
the authors declare	125
been suggested that	125
as part of	125
expressed in e	125
are found in	125
of the plasma	125
in this way	125
and activation of	125
shows that the	125
the in vivo	124
the cytoplasmic domain	124
the determination of	124
applied to the	124
to test the	124
located at the	124
proteins and their	124
one of these	124
to enhance the	123
cd t cell	123
the risk of	123
characterized by a	123
and identification of	123
is related to	123
in the production	123
present study was	123
in the endoplasmic	123
are used to	123
critical role in	123
important roles in	123
by binding to	123
t cells and	123
there is an	123
has been observed	123
is required to	123
may play a	123
of the main	123
which could be	122
induced by the	122
synthesis of the	122
that may be	122
those of the	122
proved to be	122
nucleotide sequence of	122
the localization of	122
for the synthesis	122
are based on	122
knowledge of the	122
may also be	122
of the lipid	122
for viral replication	122
molecular mechanisms of	122
portion of the	122
cov n protein	122
the cytoplasm and	122
the results showed	121
contributes to the	121
were identified by	121
at the level	121
we demonstrate that	121
in the n	121
the er and	121
of this work	120
roles in the	120
with the host	120
under the control	120
in the liver	120
it is the	120
to the membrane	120
pseudo amino acid	120
is similar to	120
the specificity of	120
the increase in	120
response to the	120
p and p	120
information about the	120
residues of the	120
because of their	120
evolution of the	120
basis of the	120
been identified in	119
carried out in	119
in this regard	119
mhc class ii	119
basis for the	119
be important for	119
the transmembrane domain	119
the understanding of	119
we developed a	119
specificity of the	119
this is a	119
studies showed that	119
we used the	119
an example of	118
we have previously	118
wide variety of	118
has recently been	118
described in the	118
of a large	118
was detected in	118
depend on the	118
to each other	118
our results suggest	118
well as a	118
the preparation of	118
in accordance with	118
could be a	118
total number of	117
identified as a	117
in this paper	117
to the n	117
the selection of	117
is also a	117
of s protein	117
the occurrence of	117
we studied the	117
into the cytoplasm	117
the incorporation of	117
along with the	117
may be involved	117
but it is	117
in the plasma	117
balb c mice	117
mode of action	117
mutation in the	117
at least in	117
the contribution of	116
the percentage of	116
as it is	116
was measured by	116
in this process	116
an inhibitor of	116
the translation of	116
production of recombinant	116
been identified as	116
the proteins were	116
a better understanding	116
our results show	116
the appearance of	116
from the cell	116
in a single	116
type i ifn	116
strand rna viruses	115
the transport of	115
and the other	115
size exclusion chromatography	115
the hypothesis that	115
breast cancer cells	115
the fusion protein	115
high degree of	115
with a high	115
we have also	115
is found in	115
with that of	115
the results obtained	115
a central role	115
been associated with	115
proteins were identified	115
are required to	115
in both the	115
production of the	114
heat shock proteins	114
of the other	114
is known that	114
to detect the	114
before and after	114
for use in	114
molecular weight of	114
a mixture of	114
focus on the	113
that in the	113
protein with a	113
to be associated	113
belonging to the	113
low molecular weight	113
serves as a	112
of type i	112
aspects of the	112
a wide variety	112
nuclear magnetic resonance	112
number of proteins	112
green fluorescent protein	112
is the major	112
investigation of the	112
interfere with the	112
to the same	112
the influenza virus	112
is a highly	112
followed by the	112
analysis revealed that	112
proteins and the	112
of proteins with	112
major histocompatibility complex	111
which have been	111
into the host	111
in a variety	111
of the virion	111
results demonstrate that	111
the hepatitis c	111
characterized by the	111
a significant increase	111
of the structural	111
belong to the	111
of these two	111
the united states	111
degradation of the	111
of the innate	111
an overview of	111
the type of	111
we analyzed the	111
and for the	111
conformation of the	110
in a cell	110
cells treated with	110
of the study	110
translation of the	110
functional analysis of	110
infected cells and	110
it is likely	110
to form the	110
molecular basis of	110
of the severe	110
data show that	109
in the expression	109
with and without	109
evaluation of the	109
a major role	109
modification of the	109
based on these	109
closely related to	109
an increase of	109
by western blotting	109
as described previously	109
organization of the	109
central role in	109
based on their	109
be applied to	109
was associated with	109
vivo and in	108
only a few	108
by interacting with	108
position of the	108
the protein was	108
removal of the	108
with each other	108
gene expression and	108
study is to	108
is necessary to	108
impact on the	108
of escherichia coli	108
are thought to	108
model of the	108
that they are	108
protein that is	108
the progression of	108
transported to the	108
not yet been	108
the molecular basis	108
to compare the	108
the complexity of	108
the virus to	108
spike protein of	107
for production of	107
many of these	107
the construction of	107
in the c	107
we have investigated	107
indicates that the	107
an essential role	107
from the same	107
zhang et al	107
the first step	107
inserted into the	107
and development of	107
is expressed in	107
the viral replication	106
used to study	106
we used a	106
of the structure	106
we report the	106
the cytoplasmic tail	106
is believed to	106
activated protein kinase	106
used in this	106
expression level of	106
on the protein	106
according to their	106
known about the	106
innate immune system	106
cell proliferation and	106
been reported in	106
to confirm the	106
g for min	106
is a common	106
analysis of a	105
decrease in the	105
is a member	105
in most cases	105
is not known	105
recent advances in	105
difference between the	105
coronavirus infectious bronchitis	105
innate and adaptive	105
only in the	105
the secretion of	105
of autophagy in	105
lead to a	105
two types of	105
as determined by	105
terminal region of	105
were performed using	104
the phosphorylation of	104
processing of the	104
part of a	104
major role in	104
peptides and proteins	104
of the vaccine	104
programmed cell death	104
identification and characterization	104
significant increase in	104
these results indicate	104
a protein of	104
the current study	104
secondary structure of	104
the case for	104
leading to a	104
we examined the	104
the idea that	103
these data suggest	103
were performed in	103
and inhibition of	103
function in the	103
at the plasma	103
mechanisms by which	103
we demonstrated that	103
in the cytosol	103
we present a	103
importance of the	103
each of these	103
we have identified	103
vero e cells	103
in viral replication	103
of more than	103
necessary for the	103
consists of a	103
analysis showed that	103
caused by a	103
in breast cancer	103
there are two	103
are capable of	103
the rest of	102
is expected to	102
of protein synthesis	102
subunit of the	102
development of new	102
shown in table	102
protein of interest	102
result of the	102
for the formation	102
transmissible gastroenteritis virus	102
evidence that the	102
in the second	102
is not a	102
the transfer of	102
the removal of	102
of n protein	102
a lack of	102
b and c	102
allowed us to	102
for treatment of	102
they can be	102
it is well	102
in the current	102
of porcine epidemic	101
findings suggest that	101
west nile virus	101
release of the	101
binding domain of	101
in the lung	101
and may be	101
to this end	101
sites in the	101
of the four	101
a component of	101
chen et al	101
in saccharomyces cerevisiae	101
is predicted to	101
considered as a	101
for the design	101
a highly conserved	101
in more detail	101
domains of the	101
high level of	101
was performed to	101
the protein and	101
has been developed	101
viral rna synthesis	101
early stages of	101
were infected with	101
that the n	101
to obtain a	101
believed to be	101
we are currently	101
the significance of	100
the transcription factor	100
of all the	100
our results indicate	100
was applied to	100
expression in the	100
of the novel	100
because of its	100
the orf protein	100
protein from the	100
of the nuclear	100
of the full	100
the human genome	100
and western blot	100
and mass spectrometry	100
be noted that	100
the fusion peptide	100
the cytoplasm of	100
been proposed to	99
differentially expressed proteins	99
is an essential	99
the lumen of	99
t cell responses	99
in association with	99
were selected for	99
of extracellular vesicles	99
to contribute to	99
the ratio of	99
evs were isolated	99
the viral envelope	99
deletion of the	99
active site of	99
structural proteins of	99
levels in the	99
was performed in	99
evidence for the	99
fact that the	99
was isolated from	99
affected by the	99
multiple sequence alignment	99
protein interacts with	98
the university of	98
to be determined	98
been reported that	98
polymerase chain reaction	98
relative to the	98
in the rat	98
protein structure and	98
may serve as	98
of proteins that	98
is in the	98
as described in	98
a part of	98
there are several	98
is the case	98
in the nucleolus	98
the structures of	98
reduction of the	98
of at least	98
and regulation of	98
inhibitors of the	98
t cell activation	98
this type of	98
protein to the	97
was identified as	97
is not clear	97
oxidative stress and	97
increased expression of	97
n protein is	97
the structural proteins	97
when compared with	97
of mouse hepatitis	97
to the host	97
cells transfected with	97
the relevance of	97
was obtained from	97
the maintenance of	97
difference in the	97
we propose that	97
a model of	97
did not show	96
were characterized by	96
it will be	96
were collected from	96
are characterized by	96
phosphorylation of the	96
differences between the	96
listed in table	96
is the main	96
or absence of	96
in the blood	96
newcastle disease virus	96
both in vitro	96
the spike glycoprotein	96
is likely that	96
of the family	96
we observed a	96
detection of the	96
in a dose	96
step in the	95
genome sequence of	95
used as an	95
in conjunction with	95
a mouse model	95
the structural and	95
the human proteome	95
in a number	95
can be applied	95
the search for	95
and subjected to	95
with severe acute	95
should be noted	95
the conformation of	95
localized to the	95
dynamics of the	95
to be important	95
in the course	95
of up to	95
was performed on	95
of the hiv	95
pv a pro	95
the cleavage of	95
the b protein	95
been used in	94
the investigation of	94
the value of	94
the entry of	94
and release of	94
here we present	94
in presence of	94
surface plasmon resonance	94
the increase of	94
in the cytoplasmic	94
the roles of	94
s protein of	94
that do not	94
we have found	94
of the brain	94
presence or absence	94
interacting with the	94
in the virus	94
the initiation of	94
been found in	94
with the aim	94
could be detected	94
fold increase in	94
functions as a	94
were used in	93
characteristics of the	93
sequence analysis of	93
increase of the	93
did not affect	93
the novel coronavirus	93
of the central	93
that there are	93
the uptake of	93
the position of	93
to the control	93
the location of	93
in a mouse	93
rest of the	93
swine fever virus	93
were identified as	93
blood samples were	93
are needed to	93
into the nucleus	93
and amino acid	93
result in the	93
have developed a	93
biological activity of	93
involvement of the	93
proteins associated with	93
genes involved in	93
for the presence	93
correlation between the	93
the study was	93
of hepatitis b	92
incorporated into the	92
of the entire	92
tool for the	92
s protein is	92
the establishment of	92
crystal structures of	92
the order of	92
this work is	92
of the molecule	92
we hypothesize that	92
nuclear pore complex	92
their role in	92
can be detected	92
to note that	92
is a novel	92
the diagnosis of	92
have been studied	92
also been shown	92
than in the	92
agreement with the	92
the goal of	92
and on the	92
to the surface	92
development of novel	92
cov and sars	92
the binding affinity	92
to generate a	92
as shown by	92
interactions of the	92
membrane of the	92
there are no	91
to provide a	91
amino acids of	91
fused to the	91
it was also	91
isolation and characterization	91
of the ligand	91
a panel of	91
the delivery of	91
recent studies have	91
smooth muscle cells	91
the unfolded protein	91
association of the	91
to better understand	91
to the c	91
the origin of	91
correlated with the	91
been used for	91
of viral replication	91
as an alternative	91
to interfere with	91
protein expression in	91
carried out using	91
with or without	91
is not yet	91
the emergence of	90
receptor binding domain	90
a study of	90
we have recently	90
of protein sequences	90
was performed with	90
the total number	90
of dengue virus	90
to the presence	90
synthesis of a	90
in t cells	90
been proposed that	90
were identified in	90
proteins in a	90
appeared to be	90
level of the	90
is the only	90
it does not	90
and found that	90
of the small	90
may be used	90
the composition of	90
were analysed by	90
of the native	90
coronavirus envelope protein	89
not required for	89
sites of the	89
point of view	89
with the use	89
this protein is	89
for the study	89
influence of the	89
produced by the	89
in a wide	89
thermo fisher scientific	89
and cd t	89
downstream of the	89
of the mrna	89
role for the	89
well as to	89
bovine serum albumin	89
the interactions of	89
protein with the	88
quantitative analysis of	88
protein interaction networks	88
in the cns	88
can be considered	88
protein disulfide isomerase	88
the samples were	88
that interact with	88
with the viral	88
can be achieved	88
in cells infected	88
was reported to	88
the viral proteins	88
to be highly	88
a review of	88
context of the	88
in spite of	88
yet to be	88
to define the	88
conformational changes in	88
a comparison of	88
required for efficient	88
a change in	88
to measure the	88
more than of	87
as a new	87
the mode of	87
new insights into	87
of the orf	87
of the sequence	87
van der waals	87
reduction in the	87
was determined using	87
the affinity of	87
has led to	87
to act as	87
this may be	87
d structure of	87
in the sars	87
peptides derived from	87
from the nucleus	87
values of the	87
s protein was	87
internal ribosome entry	87
the presence or	87
to the viral	87
acid sequence of	87
in the binding	87
be detected in	87
large amounts of	87
of these cells	86
which results in	86
results indicated that	86
to control the	86
expected to be	86
i and ii	86
in animal models	86
and is a	86
of the transmembrane	86
cytoplasmic domain of	86
in the united	86
e and e	86
are related to	86
it would be	86
host immune response	86
been described in	86
is well known	86
to obtain the	86
we have studied	86
of our study	86
essential role in	86
advantage of the	86
demonstrate that the	86
viral life cycle	86
which leads to	86
amino acids are	86
conflict of interest	86
model for the	86
would like to	86
changes of the	86
in the number	86
mrna and protein	86
was analyzed by	86
and the protein	86
a model for	86
on the structure	86
the sensitivity of	85
cell growth and	85
m protein is	85
could also be	85
a protein is	85
and purification of	85
of the expression	85
of the cytoplasmic	85
of reactive oxygen	85
were detected by	85
or in the	85
has shown that	85
as an example	85
of t cell	85
as an important	85
and have been	85
class i molecules	85
is independent of	85
viral and cellular	85
immune response in	85
three times with	85
our data suggest	85
view of the	85
of host proteins	85
molecular dynamics simulation	85
translation initiation factor	85
of the nsp	85
evidence suggests that	85
been observed in	85
on the contrary	85
of the yeast	85
known as the	84
plasma membrane and	84
in the design	84
were measured by	84
participate in the	84
of the corresponding	84
protein can be	84
a source of	84
the basis for	84
into the cytosol	84
the protein data	84
in human cells	84
of the non	84
affinity of the	84
in vitro studies	84
the host cells	84
that are not	84
proteins of sars	84
the reduction of	84
cell death in	84
of the whole	84
lumen of the	84
formed by the	84
phase peptide synthesis	84
were added to	83
even in the	83
academy of sciences	83
of the patients	83
of the surface	83
be explained by	83
methods have been	83
reported that the	83
of cd t	83
laser desorption ionization	83
for each of	83
the modulation of	83
the fusion of	83
the group of	83
the capsid protein	83
h and h	83
the possibility to	83
can be seen	83
innate immune responses	83
attributed to the	83
can be obtained	83
action of the	83
e ubiquitin ligase	83
of the mouse	83
the protein to	83
replication and transcription	83
of t cells	83
by the addition	83
in the cells	83
the two proteins	82
the nuclear pore	82
immune responses to	82
protein is the	82
in clinical trials	82
a concentration of	82
is used for	82
be useful in	82
also involved in	82
the last years	82
the beginning of	82
for the analysis	82
be attributed to	82
that bind to	82
is determined by	82
it is necessary	82
recognition of the	82
gd t cells	82
of in vitro	82
well as for	82
of proteins from	82
rna chaperone activity	82
by use of	82
recombinant s protein	82
of the new	82
health and disease	82
coronavirus e protein	82
the viral life	82
able to induce	82
a target for	82
and stability of	82
has been implicated	81
limited number of	81
used to predict	81
quality of the	81
the expression level	81
located on the	81
a pivotal role	81
viruses such as	81
and western blotting	81
purpose of this	81
a high degree	81
concentration of the	81
receptor for the	81
of rna viruses	81
crucial for the	81
and the resulting	81
respiratory syndrome virus	81
world health organization	81
may be the	81
integral membrane protein	81
virus infection in	81
protein as a	81
kim et al	81
proven to be	81
shown to have	81
highly expressed in	81
the incidence of	81
in regulation of	81
was based on	81
atomic force microscopy	81
from the endoplasmic	81
light on the	81
in figure a	81
comparative analysis of	81
with a single	81
on the same	81
t cells were	80
of cellular proteins	80
were tested for	80
there has been	80
the molecular mechanism	80
domain in the	80
are expected to	80
the recombinant protein	80
for binding to	80
increased levels of	80
this process is	80
transmembrane domain of	80
broad range of	80
the hydrolysis of	80
coronavirus associated with	80
is difficult to	80
there are many	80
in hela cells	80
linked immunosorbent assay	80
be useful for	80
proteins may be	80
ion channel activity	80
as one of	80
site in the	80
in drug discovery	80
of a given	80
cells and the	80
reported in the	80
is part of	80
integral membrane proteins	80
the advantage of	80
association with the	80
by addition of	80
t cells in	80
of semliki forest	79
inhibitor of the	79
the transcription of	79
molecular mass of	79
the probability of	79
the free energy	79
of a number	79
targeted to the	79
resonance energy transfer	79
studies have been	79
in our laboratory	79
here we report	79
seen in the	79
of the system	79
washed three times	79
protein synthesis in	79
mechanisms involved in	79
in the mouse	79
mesenchymal stem cells	79
for the generation	79
spike protein and	79
a method for	79
to address this	79
play important roles	79
by the use	79
and at the	79
have investigated the	79
evidence for a	79
and the c	79
contact with the	79
location of the	79
a new coronavirus	79
protein expression and	79
has been recently	79
relationship between the	78
dimensional structure of	78
prior to the	78
result in a	78
protein expressed in	78
upstream of the	78
the nervous system	78
function as a	78
to overcome the	78
the mechanism by	78
give rise to	78
of vesicular stomatitis	78
molecular mechanism of	78
of the nucleocapsid	78
of these peptides	78
in the two	78
n protein of	78
aim of our	78
mouse model of	78
the proteins of	78
all of these	78
transcription and translation	78
been detected in	78
not affected by	78
this work we	78
of the capsid	78
the capacity of	78
and to the	78
but not the	78
to the fact	78
of both the	78
of novel coronavirus	78
the evaluation of	78
samples were collected	78
proteins with a	78
had no effect	78
is used as	78
also be used	77
subunits of the	77
in the genome	77
and bat cov	77
we find that	77
the outcome of	77
but also in	77
cells were infected	77
performed using the	77
in the sequence	77
different stages of	77
and analyzed by	77
cell lines and	77
on the presence	77
are consistent with	77
can serve as	77
a and a	77
recombinant protein production	77
a class of	77
production of a	77
of the hepatitis	77
of the active	77
proteins on the	77
incubated for h	77
released from the	77
endoplasmic reticulum stress	77
occurs in the	77
in the spike	77
assisted laser desorption	77
to produce a	77
of the infection	77
we hypothesized that	77
the expression levels	77
fusion of the	77
in the lungs	77
is a potent	77
in a similar	77
for vaccine development	77
was expressed in	77
class ii fusion	77
it possible to	77
interactions in the	77
can result in	76
patients with severe	76
play a crucial	76
we found a	76
of the wild	76
conclude that the	76
for in vitro	76
porcine reproductive and	76
can be easily	76
protein and its	76
efficiency of the	76
localized in the	76
cells were treated	76
proteins encoded by	76
of the catalytic	76
it is clear	76
the choice of	76
in the serum	76
functional characterization of	76
a period of	76
data on the	76
capacity of the	76
surface expression of	76
with the highest	76
in a protein	76
used to detect	76
regulated by the	76
the separation of	76
the severity of	76
of the compounds	75
fraction of the	75
we believe that	75
to the target	75
the results were	75
order to determine	75
the isolation of	75
of the data	75
to induce the	75
shown to interact	75
identification of novel	75
were associated with	75
the ns protein	75
this can be	75
is not required	75
of intrinsic disorder	75
of the signal	75
viral and host	75
the most potent	75
so that the	75
the presence and	75
the t cell	75
for the sars	75
observed that the	75
reproductive and respiratory	75
occur in the	75
at the surface	75
by the viral	75
plays a key	75
tobacco mosaic virus	75
were transfected with	75
cells were incubated	75
of m protein	75
application of the	75
in insect cells	75
value of the	75
been developed to	75
viral rna replication	75
african swine fever	75
of a specific	75
to the s	75
and respiratory syndrome	75
the proliferation of	75
to explain the	75
also been reported	75
of the individual	75
can interact with	74
the content of	74
the problem of	74
it has also	74
protein interactions and	74
higher than that	74
the viral protein	74
the gene encoding	74
modulation of the	74
virus replication and	74
the difference in	74
most of these	74
involved in a	74
independent of the	74
of the endoplasmic	74
activity of a	74
has been widely	74
to reveal the	74
sensitivity and specificity	74
corresponds to the	74
was also observed	74
is sufficient to	74
to generate the	74
the spinal cord	74
are in the	74
a decrease of	74
the human immunodeficiency	74
protein synthesis and	74
the class i	74
involved in cell	74
was induced by	74
single amino acid	74
polyacrylamide gel electrophoresis	74
into the cell	74
has been studied	74
be required for	74
the help of	74
the need to	74
the results suggest	74
entry into the	74
ranging from to	74
have been observed	74
is linked to	74
been applied to	74
protein folding and	74
porcine circovirus type	74
was evaluated by	74
binding sites in	74
terminal part of	73
presence of an	73
and incubated at	73
may be due	73
a role of	73
of class i	73
binding sites for	73
binding affinity of	73
infected with the	73
target for the	73
of the identified	73
the abundance of	73
to our knowledge	73
of the primary	73
provided by the	73
be achieved by	73
host protein synthesis	73
replication of the	73
work was to	73
to be in	73
for the prediction	73
processes such as	73
an immune response	73
of the pore	73
and dynamics of	73
we aim to	73
systemic lupus erythematosus	73
of the channel	73
rna polymerase ii	73
to the high	73
a reduction in	73
of the secretory	73
approved by the	73
the yield of	73
the activities of	73
with the exception	73
be essential for	73
the family of	73
plasma membrane of	73
can bind to	73
order to identify	73
are predicted to	73
is inhibited by	73
of these viruses	72
to changes in	72
it could be	72
were exposed to	72
content of the	72
immune response and	72
enzymes involved in	72
amino acid residue	72
the a protein	72
residue in the	72
to the vacuole	72
carried out on	72
over the last	72
graphical representation of	72
lee et al	72
structural characterization of	72
in these cells	72
were expressed in	72
derived from a	72
class i and	72
the expression and	72
the development and	72
were isolated by	72
taken into account	72
are listed in	72
to facilitate the	72
of a viral	72
rational design of	72
these findings suggest	72
been suggested to	72
over the past	72
on the use	72
due to an	72
with the membrane	72
cell cycle progression	72
been demonstrated to	72
small number of	72
carried out to	72
higher than the	72
the protein of	72
cytoplasmic tail of	71
may result in	71
to the human	71
in the structure	71
negative regulator of	71
of the process	71
peripheral blood mononuclear	71
prediction of the	71
based on this	71
of a variety	71
is clear that	71
two of the	71
protein interaction network	71
t cell receptor	71
during the first	71
red blood cells	71
cell cycle arrest	71
significantly higher in	71
there is evidence	71
as a control	71
of the anti	71
previous studies have	71
blood mononuclear cells	71
with the protein	71
were performed to	71
role of this	71
extracted from the	71
compared to controls	71
for virus replication	71
are expressed in	71
no significant difference	71
sequences in the	71
to be able	71
the protein structure	71
protein structure prediction	71
the biological activity	71
supplementary table s	71
study was supported	71
of molecular biology	71
we present the	71
of the genes	71
in cancer cells	71
is needed to	71
used to generate	71
the vaccine construct	71
from a single	71
transport of the	71
on the host	71
decrease of the	70
of monoclonal antibodies	70
were significantly higher	70
the protein in	70
the sequences of	70
factors such as	70
from the protein	70
also able to	70
the supernatant was	70
not essential for	70
dynamic light scattering	70
the influenza a	70
a basis for	70
orders of magnitude	70
may be important	70
absence of the	70
in many cases	70
spike protein is	70
in which a	70
s protein and	70
of the g	70
in the p	70
aim is to	70
we compared the	70
the age of	70
to create a	70
antigenicity of the	70
recognized by the	70
as they are	70
is activated by	70
at the site	70
the utility of	70
example of a	70
pi k akt	70
cell lines were	70
and incubated for	70
have been made	70
interest in the	70
of protein folding	70
morbidity and mortality	70
is essential to	70
the accuracy of	70
cell surface receptors	70
to the identification	70
was detected by	70
could lead to	70
play a key	70
critical for the	70
by a single	69
wild type and	69
cancer cell line	69
remain to be	69
to address the	69
the virus and	69
were grown in	69
n protein in	69
immune response against	69
of membrane fusion	69
also in the	69
have found that	69
in situ hybridization	69
a reduction of	69
to prevent the	69
p ink a	69
in the identification	69
and it has	69
the virus is	69
of protein structures	69
cells were washed	69
cov and mers	69
overview of the	69
a loss of	69
transport to the	69
was achieved by	69
respiratory distress syndrome	69
that are involved	69
the results show	69
able to bind	69
influenced by the	69
of this approach	69
exposed to the	69
of the above	69
might be a	69
and it was	69
been demonstrated that	69
n protein was	69
with the human	69
of protein structure	69
expressed in a	69
expression of cd	69
optimization of the	69
authors declare no	69
by the fact	69
protein secondary structure	69
positive and negative	69
as the most	69
the pattern of	69
a protein sequence	68
of the bacterial	68
of some of	68
the receptor binding	68
to be considered	68
and is the	68
of the genus	68
integrity of the	68
that they have	68
involved in viral	68
the s domain	68
taking into account	68
to serve as	68
to investigate whether	68
protein interactions in	68
supported by a	68
of expression of	68
of the proteasome	68
also found in	68
is a powerful	68
in the immune	68
addition of the	68
we focused on	68
has the potential	68
signal transduction pathways	68
the p protein	68
of the current	68
to monitor the	68
and as a	68
this is not	68
the outer membrane	68
of the reaction	68
of the model	68
were compared with	68
is induced by	68
is not the	68
protein encoded by	68
of a peptide	68
by measuring the	68
the spread of	68
response of the	68
the overexpression of	68
were cultured in	68
the most commonly	68
to determine if	68
of recombinant protein	68
forms of the	68
to the cytosol	68
the vast majority	68
also been used	68
can be a	68
do not have	67
of the porcine	67
protein involved in	67
version of the	67
hcv core protein	67
of a particular	67
murine leukemia virus	67
genes in the	67
of this review	67
in the extracellular	67
as a negative	67
the target cell	67
potential role of	67
transforming growth factor	67
hepatitis a virus	67
are used for	67
the comparison of	67
be divided into	67
but also to	67
are used in	67
in the interaction	67
the effectiveness of	67
alterations in the	67
myelin basic protein	67
which is an	67
c virus core	67
vast majority of	67
on the expression	67
under these conditions	67
required for viral	67
by the host	67
of the manuscript	67
to optimize the	67
class ii mhc	67
b cell epitopes	67
role in viral	67
were performed on	67
of the nucleolus	67
in view of	67
experiments were performed	67
and treatment of	67
induction of the	67
in the active	67