This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.
quadgram | frequency |
---|---|
severe acute respiratory syndrome | 1179 |
in the presence of | 1006 |
acute respiratory syndrome coronavirus | 711 |
on the other hand | 598 |
in the case of | 579 |
has been shown to | 533 |
in the absence of | 523 |
as well as the | 511 |
is one of the | 437 |
an important role in | 432 |
one of the most | 374 |
in vitro and in | 366 |
was found to be | 347 |
of severe acute respiratory | 338 |
vitro and in vivo | 336 |
in the present study | 335 |
on the surface of | 331 |
can be used to | 329 |
have been shown to | 324 |
in the context of | 321 |
in the regulation of | 319 |
for the development of | 317 |
on the basis of | 310 |
for the treatment of | 309 |
a wide range of | 306 |
the aim of this | 293 |
play a role in | 270 |
in the development of | 270 |
been shown to be | 258 |
of this study was | 255 |
the severe acute respiratory | 255 |
as well as in | 251 |
it has been shown | 250 |
the structure of the | 249 |
human immunodeficiency virus type | 248 |
aim of this study | 242 |
as a result of | 240 |
middle east respiratory syndrome | 239 |
a large number of | 236 |
this study was to | 230 |
at the same time | 229 |
in addition to the | 228 |
play an important role | 227 |
the presence of the | 227 |
were found to be | 226 |
to be involved in | 225 |
has been shown that | 216 |
for the first time | 215 |
the presence of a | 210 |
the role of the | 209 |
for the production of | 204 |
porcine epidemic diarrhea virus | 203 |
the end of the | 201 |
in the formation of | 199 |
work was supported by | 198 |
this work was supported | 197 |
the central nervous system | 196 |
plays an important role | 195 |
the surface of the | 191 |
in the pathogenesis of | 188 |
east respiratory syndrome coronavirus | 182 |
it is important to | 177 |
the formation of the | 177 |
it was found that | 175 |
to the cell surface | 174 |
the expression of the | 174 |
at the end of | 172 |
a key role in | 171 |
we were able to | 170 |
a member of the | 167 |
in this study we | 166 |
herpes simplex virus type | 164 |
of hepatitis c virus | 163 |
r o o f | 161 |
l p r e | 161 |
o u r n | 161 |
u r n a | 161 |
it was shown that | 161 |
n a l p | 161 |
p r o o | 161 |
a l p r | 161 |
j o u r | 161 |
r n a l | 161 |
in the treatment of | 160 |
are involved in the | 159 |
to the plasma membrane | 159 |
it is possible to | 156 |
important role in the | 155 |
these results suggest that | 154 |
is based on the | 153 |
it is possible that | 153 |
in the form of | 149 |
is involved in the | 146 |
of the s protein | 146 |
a role in the | 145 |
of the spike protein | 144 |
be involved in the | 143 |
the formation of a | 138 |
can be used for | 138 |
for the detection of | 138 |
was shown to be | 137 |
a crucial role in | 135 |
little is known about | 134 |
to the formation of | 134 |
to the development of | 133 |
we found that the | 133 |
in contrast to the | 132 |
has been reported to | 132 |
of the n protein | 130 |
as a function of | 130 |
with respect to the | 130 |
the nature of the | 129 |
of herpes simplex virus | 129 |
is required for the | 128 |
by the presence of | 128 |
studies have shown that | 127 |
as shown in fig | 127 |
of human immunodeficiency virus | 127 |
the crystal structure of | 126 |
can be used as | 125 |
it has been suggested | 125 |
the aim of the | 125 |
similar to that of | 124 |
on the cell surface | 123 |
the development of a | 123 |
crystal structure of the | 123 |
in the endoplasmic reticulum | 122 |
for the identification of | 120 |
under the control of | 120 |
at the level of | 119 |
as well as a | 118 |
to that of the | 118 |
was supported by the | 118 |
the function of the | 117 |
has been suggested that | 116 |
the present study was | 116 |
of the sars coronavirus | 115 |
a better understanding of | 114 |
of the amino acid | 114 |
the size of the | 114 |
plays a role in | 113 |
the effect of the | 113 |
for the synthesis of | 113 |
pseudo amino acid composition | 113 |
a critical role in | 113 |
has been used to | 112 |
a wide variety of | 112 |
the amino acid sequence | 112 |
it is known that | 112 |
in a variety of | 111 |
may be involved in | 111 |
at the time of | 111 |
the activation of the | 110 |
our understanding of the | 110 |
structure and function of | 109 |
to be associated with | 109 |
the ability of the | 108 |
the hepatitis c virus | 108 |
of the severe acute | 108 |
have been used to | 107 |
at the cell surface | 107 |
in the range of | 106 |
was used as a | 106 |
and characterization of a | 106 |
the results showed that | 106 |
the case of the | 105 |
coronavirus infectious bronchitis virus | 105 |
we have shown that | 105 |
the activity of the | 104 |
in the field of | 104 |
the majority of the | 104 |
is a member of | 104 |
an increase in the | 103 |
in the production of | 103 |
identification and characterization of | 103 |
at the plasma membrane | 102 |
one of the major | 102 |
can be found in | 102 |
a central role in | 100 |
the stability of the | 100 |
of the present study | 100 |
in vivo and in | 99 |
for the formation of | 99 |
our results show that | 98 |
the fact that the | 98 |
results suggest that the | 98 |
the analysis of the | 98 |
of this study is | 98 |
have shown that the | 97 |
our results suggest that | 97 |
is known about the | 97 |
in the process of | 96 |
in the control of | 96 |
the interaction of the | 96 |
the development of the | 95 |
it is likely that | 95 |
is thought to be | 95 |
of amino acid residues | 95 |
is responsible for the | 95 |
in the course of | 95 |
in a number of | 95 |
with severe acute respiratory | 94 |
it should be noted | 94 |
of porcine epidemic diarrhea | 93 |
is known to be | 93 |
is consistent with the | 92 |
the regulation of the | 92 |
the binding of the | 92 |
these results indicate that | 92 |
in the central nervous | 92 |
the nucleocapsid protein of | 91 |
study was to investigate | 91 |
presence or absence of | 91 |
of the immune system | 91 |
of the plasma membrane | 91 |
be used as a | 91 |
a major role in | 91 |
the basis of the | 90 |
of mouse hepatitis virus | 90 |
the results of the | 90 |
it has been reported | 89 |
as well as to | 89 |
to the presence of | 89 |
better understanding of the | 89 |
for the presence of | 89 |
as compared to the | 89 |
involved in the regulation | 89 |
as a consequence of | 88 |
vivo and in vitro | 88 |
of influenza a virus | 88 |
mechanism of action of | 88 |
with the use of | 88 |
the length of the | 88 |
the total number of | 88 |
it has been proposed | 87 |
isolation and characterization of | 87 |
to interact with the | 87 |
the rest of the | 87 |
these data suggest that | 87 |
in the present work | 87 |
both in vitro and | 86 |
that can be used | 86 |
the molecular basis of | 86 |
for the design of | 86 |
in the expression of | 86 |
of the viral genome | 86 |
of the m protein | 85 |
this is the first | 85 |
are known to be | 84 |
our results indicate that | 84 |
amino acid sequence of | 84 |
the control of the | 84 |
the use of the | 84 |
is essential for the | 83 |
the interaction between the | 83 |
the protein data bank | 83 |
the unfolded protein response | 83 |
of the target protein | 82 |
was to investigate the | 82 |
should be noted that | 82 |
as well as for | 82 |
by the addition of | 82 |
the presence or absence | 82 |
in the number of | 82 |
the active site of | 81 |
may contribute to the | 81 |
the lumen of the | 81 |
of reactive oxygen species | 81 |
from the endoplasmic reticulum | 81 |
the innate immune system | 81 |
were shown to be | 80 |
has been found to | 80 |
is likely to be | 80 |
the use of a | 79 |
has been proposed that | 79 |
a significant increase in | 79 |
epidermal growth factor receptor | 79 |
the innate immune response | 79 |
of a number of | 79 |
by the use of | 79 |
of the innate immune | 79 |
have been reported to | 78 |
this study is to | 78 |
is associated with the | 78 |
is supported by the | 78 |
a high degree of | 78 |
of semliki forest virus | 78 |
the mechanism by which | 78 |
for the analysis of | 77 |
the development of novel | 77 |
has been reported that | 77 |
the development of new | 77 |
the spike protein of | 77 |
our data suggest that | 77 |
for the generation of | 76 |
the context of the | 76 |
the mechanism of action | 76 |
is mediated by the | 76 |
in this work we | 76 |
we have developed a | 76 |
the purpose of this | 76 |
play important roles in | 75 |
the importance of the | 75 |
to the fact that | 75 |
in order to determine | 75 |
of vesicular stomatitis virus | 75 |
have been found to | 75 |
and function of the | 75 |
porcine reproductive and respiratory | 75 |
the viral life cycle | 75 |
in a mouse model | 75 |
was added to the | 74 |
in cells infected with | 74 |
the human immunodeficiency virus | 74 |
reproductive and respiratory syndrome | 74 |
an essential role in | 74 |
of the endoplasmic reticulum | 74 |
cells were treated with | 74 |
been found to be | 73 |
the identification of the | 73 |
in the united states | 73 |
also been shown to | 73 |
in order to identify | 73 |
used in this study | 73 |
aim of the present | 73 |
it has been demonstrated | 72 |
play a crucial role | 72 |
on the use of | 72 |
present study was to | 72 |
plays a key role | 72 |
of the host cell | 71 |
has been implicated in | 71 |
of the immune response | 71 |
we show that the | 71 |
of a variety of | 71 |
in the plasma membrane | 71 |
cd and cd t | 71 |
of the most important | 71 |
and respiratory syndrome virus | 71 |
the effects of the | 71 |
as shown in figure | 70 |
to be able to | 70 |
shown to interact with | 70 |
one of the main | 70 |
the aim of our | 70 |
it is clear that | 70 |
study was supported by | 70 |
for each of the | 70 |
used to determine the | 70 |
the plasma membrane and | 69 |
african swine fever virus | 69 |
for the study of | 69 |
to the identification of | 69 |
play a key role | 69 |
the expression levels of | 69 |
may play a role | 69 |
may be due to | 69 |
have been identified in | 69 |
we have investigated the | 69 |
has been demonstrated that | 68 |
by the fact that | 68 |
the sequence of the | 68 |
results showed that the | 68 |
peripheral blood mononuclear cells | 67 |
the presence of an | 67 |
has also been shown | 67 |
was observed in the | 67 |
hepatitis c virus core | 67 |
the cytoplasmic domain of | 67 |
in the design of | 67 |
be due to the | 67 |
be responsible for the | 67 |
that are involved in | 66 |
in the cytoplasm of | 66 |
assisted laser desorption ionization | 66 |
during the course of | 66 |
the secondary structure of | 66 |
on the presence of | 66 |
well as in the | 66 |
is due to the | 66 |
been reported to be | 66 |
that there is a | 65 |
at the site of | 65 |
for the prediction of | 65 |
to play a role | 65 |
than that of the | 65 |
with the exception of | 64 |
was used as the | 64 |
of hepatitis b virus | 64 |
are likely to be | 64 |
the authors declare no | 64 |
the influence of the | 64 |
is important for the | 64 |
can be used in | 64 |
with the help of | 64 |
to the lack of | 64 |
in the host cell | 64 |
had no effect on | 63 |
the expression level of | 63 |
results indicate that the | 63 |
as one of the | 63 |
washed three times with | 63 |
proteins involved in the | 62 |
characterization of a novel | 62 |
amino acid sequences of | 62 |
that the presence of | 62 |
involved in the formation | 62 |
it is necessary to | 62 |
could be used to | 62 |
it has also been | 62 |
the plasma membrane of | 62 |
at the surface of | 62 |
structural basis for the | 62 |
cells were infected with | 61 |
by western blot analysis | 61 |
structure of the protein | 61 |
no conflict of interest | 61 |
h at room temperature | 61 |
the vast majority of | 61 |
innate and adaptive immune | 61 |
in the current study | 61 |
has the potential to | 61 |
the protein of interest | 61 |
the results suggest that | 61 |
a pivotal role in | 60 |
as part of the | 60 |
in the identification of | 60 |
on the role of | 60 |
of the central nervous | 60 |
the nuclear pore complex | 60 |
is not required for | 60 |
in order to investigate | 60 |
is dependent on the | 60 |
role in the regulation | 60 |
a result of the | 60 |
vascular endothelial growth factor | 60 |
be related to the | 60 |
the s protein of | 60 |
investigate the role of | 60 |
for the induction of | 59 |
it is well known | 59 |
for h at room | 59 |
the host immune response | 59 |
the cytoplasmic tail of | 59 |
a broad range of | 59 |
the study of the | 59 |
of the role of | 59 |
due to the lack | 59 |
we have previously shown | 59 |
for their ability to | 59 |
min at room temperature | 59 |
to be responsible for | 59 |
as well as by | 58 |
been shown that the | 58 |
solid phase peptide synthesis | 58 |
internal ribosome entry site | 58 |
when compared to the | 58 |
the molecular mechanisms of | 58 |
are responsible for the | 58 |
have been developed to | 58 |
in agreement with the | 58 |
results show that the | 58 |
acute respiratory distress syndrome | 58 |
in the presence or | 58 |
these findings suggest that | 57 |
plays a crucial role | 57 |
with the aim of | 57 |
the subcellular localization of | 57 |
into the host cell | 57 |
the present study we | 57 |
the results show that | 57 |
was found that the | 56 |
incubated for h at | 56 |
in the golgi apparatus | 56 |
and cd t cells | 56 |
to an increase in | 56 |
in accordance with the | 56 |
the synthesis of the | 56 |
for min at room | 56 |
can be applied to | 56 |
as well as their | 56 |
is well known that | 56 |
respiratory syndrome coronavirus spike | 56 |
of a novel coronavirus | 56 |
a significant role in | 56 |
key role in the | 56 |
for the expression of | 56 |
has not yet been | 56 |
we have found that | 56 |
can also be used | 55 |
a decrease in the | 55 |
in health and disease | 55 |
is shown in figure | 55 |
and the role of | 55 |
the early stages of | 55 |
the coronavirus infectious bronchitis | 55 |
the authors declare that | 55 |
identification of a novel | 55 |
be used for the | 55 |
major histocompatibility complex class | 55 |
class ii fusion proteins | 55 |
the structure and function | 54 |
crucial role in the | 54 |
sars coronavirus nucleocapsid protein | 54 |
human respiratory syncytial virus | 54 |
to better understand the | 54 |
plays a central role | 54 |
proteins are involved in | 54 |
c virus core protein | 54 |
the results of this | 54 |
a new class of | 54 |
investigate the effect of | 54 |
have been implicated in | 54 |
a component of the | 54 |
is associated with a | 54 |
similar to those of | 53 |
and the presence of | 53 |
are listed in table | 53 |
of the secretory pathway | 53 |
has been proposed to | 53 |
to the golgi complex | 53 |
and the development of | 53 |
in the generation of | 53 |
a negative regulator of | 53 |
nucleotide sequence of the | 53 |
production of recombinant proteins | 53 |
our results showed that | 53 |
is shown in fig | 53 |
to investigate the effect | 53 |
to be important for | 53 |
in terms of the | 53 |
as a source of | 53 |
the assembly of the | 53 |
at room temperature for | 53 |
have previously shown that | 53 |
the quality of the | 53 |
of the golgi apparatus | 53 |
the expression of a | 53 |
the mechanisms by which | 53 |
been shown to interact | 52 |
play a critical role | 52 |
in order to study | 52 |
the d structure of | 52 |
amino acids in the | 52 |
revealed the presence of | 52 |
compared to the control | 52 |
the existence of a | 52 |
of the fusion protein | 52 |
of the e protein | 52 |
and the number of | 52 |
on the one hand | 52 |
is predicted to be | 52 |
cells were transfected with | 52 |
plays a critical role | 52 |
is the most common | 52 |
to be the most | 52 |
is considered to be | 52 |
of the most common | 52 |
have the potential to | 52 |
a broad spectrum of | 51 |
was used for the | 51 |
have been developed for | 51 |
terminal domain of the | 51 |
in the nucleus and | 51 |
be one of the | 51 |
evs were isolated from | 51 |
the influenza a virus | 51 |
it is difficult to | 51 |
to the use of | 51 |
of the influenza virus | 51 |
has been identified as | 51 |
can be divided into | 51 |
a limited number of | 51 |
in a wide range | 51 |
was carried out by | 51 |
on the development of | 51 |
and is required for | 50 |
amino acid residues in | 50 |
been implicated in the | 50 |
of middle east respiratory | 50 |
are present in the | 50 |
was carried out using | 50 |
would like to thank | 50 |
the first time that | 50 |
it is interesting to | 50 |
the absence of the | 50 |
is present in the | 50 |
in the activation of | 50 |
it was observed that | 50 |
the changes in the | 50 |
the s protein is | 50 |
can be considered as | 50 |
on the expression of | 50 |
of infectious bronchitis virus | 50 |
that are able to | 50 |
to be used in | 50 |
was used to determine | 50 |
the most commonly used | 50 |
is believed to be | 50 |
we would like to | 50 |
of cd t cells | 50 |
may serve as a | 50 |
have been associated with | 49 |
orf a and orf | 49 |
to be essential for | 49 |
the results indicate that | 49 |
the amino acid sequences | 49 |
to investigate the role | 49 |
by nanoparticle tracking analysis | 49 |
in the synthesis of | 49 |
and functional analysis of | 49 |
play a major role | 49 |
were used for the | 49 |
is the number of | 49 |
is related to the | 49 |
have been identified as | 49 |
to the surface of | 49 |
the host immune system | 49 |
the specificity of the | 49 |
avian infectious bronchitis virus | 49 |
have not yet been | 49 |
these results demonstrate that | 49 |
at the molecular level | 49 |
through the use of | 49 |
at a concentration of | 48 |
could be used for | 48 |
is similar to that | 48 |
in the spike protein | 48 |
critical role in the | 48 |
is part of the | 48 |
hepatitis c virus infection | 48 |
the transmembrane domain of | 48 |
in the near future | 48 |
aim of our study | 48 |
used to study the | 48 |
the molecular mechanism of | 48 |
have the ability to | 48 |
we have studied the | 48 |
and it has been | 48 |
associated with severe acute | 48 |
for the preparation of | 48 |
coronavirus mouse hepatitis virus | 48 |
other members of the | 48 |
terminal region of the | 48 |
is found to be | 48 |
its interaction with the | 48 |
of the amino acids | 48 |
it is not clear | 48 |
the synthesis of a | 48 |
here we show that | 47 |
this study was supported | 47 |
and characterization of the | 47 |
to the production of | 47 |
higher than that of | 47 |
were washed three times | 47 |
are required for the | 47 |
that they have no | 47 |
in the active site | 47 |
as in the case | 47 |
structure of the sars | 47 |
the biological activity of | 47 |
for the purpose of | 47 |
analysis was performed using | 47 |
data suggest that the | 47 |
a small number of | 47 |
the cell surface and | 47 |
investigated the effect of | 47 |
the determination of the | 47 |
that the majority of | 47 |
of this work was | 47 |
that the expression of | 47 |
in order to obtain | 47 |
using a combination of | 47 |
it was demonstrated that | 47 |
in the cytoplasm and | 46 |
could be used as | 46 |
in the vicinity of | 46 |
the course of the | 46 |
has been associated with | 46 |
at different time points | 46 |
is required for efficient | 46 |
protein of severe acute | 46 |
play an essential role | 46 |
due to the fact | 46 |
amino acids of the | 46 |
the formation of an | 46 |
which are involved in | 46 |
the understanding of the | 46 |
and its role in | 46 |
eukaryotic translation initiation factor | 46 |
presence and absence of | 46 |
the life cycle of | 46 |
with the plasma membrane | 46 |
role in the pathogenesis | 46 |
shown to be a | 46 |
the n protein of | 46 |
in the study of | 46 |
terminal part of the | 46 |
study the effect of | 46 |
has also been reported | 46 |
was performed using the | 46 |
in response to the | 46 |
it remains to be | 46 |
the level of the | 45 |
be considered as a | 45 |
are considered to be | 45 |
of the interaction of | 45 |
new insights into the | 45 |
shed light on the | 45 |
of the cell cycle | 45 |
from the er to | 45 |
to be required for | 45 |
in comparison to the | 45 |
mhc class i molecules | 45 |
been shown to have | 45 |
our aim was to | 45 |
the production of recombinant | 45 |
of the structure of | 45 |
as well as with | 45 |
to the activation of | 45 |
the position of the | 45 |
declare that they have | 45 |
the inhibitory effect of | 45 |
the causative agent of | 45 |
a functional receptor for | 45 |
the hepatitis b virus | 45 |
binding domain of the | 45 |
of the protein is | 45 |
small cell lung cancer | 45 |
and functional characterization of | 45 |
the conformation of the | 44 |
with the aid of | 44 |
which is associated with | 44 |
the composition of the | 44 |
may be related to | 44 |
which is involved in | 44 |
purpose of this study | 44 |
as well as other | 44 |
be associated with the | 44 |
of the lipid bilayer | 44 |
to bind to the | 44 |
for the regulation of | 44 |
and can be used | 44 |
in line with the | 44 |
to the discovery of | 44 |
the possibility that the | 44 |
due to the presence | 44 |
is the case for | 44 |
and the use of | 44 |
a high level of | 44 |
from the plasma membrane | 44 |
been shown to play | 44 |
is also involved in | 44 |
at the beginning of | 44 |
the performance of the | 44 |
of proteins in the | 44 |
were found in the | 44 |
incubated for min at | 44 |
to the golgi apparatus | 44 |
the properties of the | 44 |
the binding site of | 43 |
of coronavirus spike proteins | 43 |
the production of the | 43 |
are shown in table | 43 |
protein was found to | 43 |
authors declare that they | 43 |
of the protein and | 43 |
might be involved in | 43 |
are located in the | 43 |
of our study was | 43 |
em structure of the | 43 |
of proteins involved in | 43 |
in an attempt to | 43 |
remains to be determined | 43 |
of the viral proteins | 43 |
the interaction with the | 43 |
in the last years | 43 |
play a pivotal role | 43 |
of a series of | 43 |
declare no conflict of | 43 |
to those of the | 43 |
aim of this work | 43 |
of the expression of | 43 |
spike protein of sars | 43 |
the potential role of | 43 |
of one of the | 43 |
cells as well as | 43 |
the goal of this | 43 |
the identification of a | 43 |
in an in vitro | 43 |
the herpes simplex virus | 43 |
from the cell surface | 43 |
understanding of the molecular | 43 |
the amino acid residues | 43 |
of the protein in | 43 |
aimed to investigate the | 43 |
of the interaction between | 43 |
were observed in the | 43 |
the beginning of the | 43 |
a potent inhibitor of | 43 |
of amino acids in | 42 |
conformational changes in the | 42 |
g for min at | 42 |
this is the case | 42 |
have been reported in | 42 |
coronavirus associated with severe | 42 |
for a long time | 42 |
is characterized by a | 42 |
one of the first | 42 |
there was no significant | 42 |
the presence and absence | 42 |
binding site of the | 42 |
respiratory syndrome coronavirus nucleocapsid | 42 |
of the hepatitis c | 42 |
a part of the | 42 |
study was to determine | 42 |
fluorescence resonance energy transfer | 42 |
an overview of the | 42 |
in the spinal cord | 42 |
these data indicate that | 42 |
have a role in | 42 |
entry into host cells | 42 |
the er to the | 42 |
cells were incubated with | 42 |
is not essential for | 42 |
in the level of | 42 |
and is involved in | 42 |
used to predict the | 42 |
at different stages of | 42 |
hepatitis c virus p | 42 |
functional analysis of the | 42 |
that most of the | 42 |
leads to the formation | 41 |
of peptides and proteins | 41 |
an integral membrane protein | 41 |
respiratory syndrome coronavirus envelope | 41 |
and the effect of | 41 |
the complexity of the | 41 |
to the endoplasmic reticulum | 41 |
the endoplasmic reticulum and | 41 |
of a large number | 41 |
known to be involved | 41 |
syndrome coronavirus envelope protein | 41 |
a single amino acid | 41 |
in order to understand | 41 |
have been used for | 41 |
of the virus to | 41 |
the inhibition of the | 41 |
the molecular biology of | 41 |
is located in the | 41 |
authors declare no conflict | 41 |
the interactions between the | 41 |
which is responsible for | 41 |
central role in the | 41 |
in hepatitis c virus | 41 |
the middle of the | 41 |
syndrome coronavirus nucleocapsid protein | 41 |
secondary structure of the | 41 |
the genome of the | 41 |
more than of the | 41 |
of the effect of | 41 |
is possible that the | 41 |
in the assembly of | 40 |
crystal structure of a | 40 |
proteins as well as | 40 |
foot and mouth disease | 40 |
were detected in the | 40 |
has been demonstrated to | 40 |
the absence of a | 40 |
the world health organization | 40 |
the most widely used | 40 |
the receptor binding domain | 40 |
our results demonstrate that | 40 |
a change in the | 40 |
in the presence and | 40 |
a final concentration of | 40 |
there is evidence that | 40 |
this work was to | 40 |
we conclude that the | 40 |
order to determine the | 40 |
syndrome coronavirus spike protein | 40 |
is a functional receptor | 40 |
in the secretory pathway | 40 |
is in agreement with | 40 |
we have demonstrated that | 40 |
a consequence of the | 40 |
will be discussed in | 40 |
to determine whether the | 40 |
study was to evaluate | 40 |
department of chemical engineering | 40 |
is the result of | 40 |
national institutes of health | 40 |
this is due to | 40 |
the mechanism of the | 40 |
by a number of | 40 |
in the er and | 40 |
has been suggested to | 39 |
it is suggested that | 39 |
the rough endoplasmic reticulum | 39 |
interesting to note that | 39 |
in the s protein | 39 |
to play an important | 39 |
the production of a | 39 |
d structure of the | 39 |
the evolution of the | 39 |
functional characterization of the | 39 |
it is believed that | 39 |
at least in part | 39 |
did not affect the | 39 |
the molecular mechanisms underlying | 39 |
are shown in figure | 39 |
s protein of sars | 39 |
to interfere with the | 39 |
an increasing number of | 39 |
in view of the | 39 |
compared to that of | 39 |
of the human genome | 39 |
plays a major role | 39 |
be used in the | 39 |
for a number of | 39 |
as a model system | 39 |
used to identify the | 39 |
the characterization of the | 39 |
important to note that | 39 |
on the structure of | 39 |
as described in the | 39 |
hepatitis b surface antigen | 39 |
novel coronavirus associated with | 39 |
to a lesser extent | 39 |
functional receptor for the | 39 |
to be used as | 39 |
in the majority of | 39 |
of cd and cd | 39 |
a novel coronavirus associated | 39 |
the location of the | 39 |
molecular dynamics simulations of | 39 |
no effect on the | 39 |
the binding affinity of | 39 |
could be involved in | 39 |
one of the two | 39 |
have been found in | 38 |
are essential for the | 38 |
to contribute to the | 38 |
may be important for | 38 |
in comparison with the | 38 |
is used as a | 38 |
patients with severe acute | 38 |
as well as its | 38 |
sequence analysis of the | 38 |
of the human proteome | 38 |
due to the high | 38 |
congo hemorrhagic fever virus | 38 |
of the presence of | 38 |
was identified as a | 38 |
as a part of | 38 |
major role in the | 38 |
taking into account the | 38 |
as a basis for | 38 |
which can be used | 38 |
and antigenicity of the | 38 |
in addition to its | 38 |
complete nucleotide sequence of | 38 |
of porcine circovirus type | 38 |
have been used in | 38 |
our data show that | 38 |
of this work is | 38 |
the genome sequence of | 38 |
are one of the | 38 |
for the diagnosis of | 38 |
the structural proteins of | 38 |
the immune response to | 38 |
we aimed to investigate | 38 |
to be present in | 38 |
has been observed in | 38 |
the concentration of the | 37 |
in the same way | 37 |
to the synthesis of | 37 |
the detection of the | 37 |
from the nucleus to | 37 |
by grants from the | 37 |
for a variety of | 37 |
in the induction of | 37 |
but not in the | 37 |
of the vaccine construct | 37 |
be important for the | 37 |
be taken into account | 37 |
have been identified by | 37 |
protein structure and function | 37 |
is interesting to note | 37 |
to the active site | 37 |
there was a significant | 37 |
is important to note | 37 |
with a variety of | 37 |
be explained by the | 37 |
by the observation that | 37 |
it was suggested that | 37 |
role of autophagy in | 37 |
a mouse model of | 37 |
in close proximity to | 37 |
the distribution of the | 37 |
in a way that | 37 |
with the host cell | 37 |
has been widely used | 37 |
food and drug administration | 37 |
have been proposed to | 37 |
of the novel coronavirus | 37 |
vascular smooth muscle cells | 37 |
order to investigate the | 37 |
a flow rate of | 37 |
did not show any | 37 |
by binding to the | 37 |
appears to be a | 37 |
in combination with the | 37 |
the structural and functional | 37 |
was added to each | 37 |
by a combination of | 37 |
despite the fact that | 37 |
to the host cell | 37 |
and the expression of | 37 |
was supported by grants | 37 |
in the levels of | 36 |
which is known to | 36 |
the role of this | 36 |
expressed in escherichia coli | 36 |
is the use of | 36 |
the integrity of the | 36 |
the localization of the | 36 |
at the nonpermissive temperature | 36 |
shown to play a | 36 |
of the th century | 36 |
human umbilical vein endothelial | 36 |
the application of the | 36 |
as well as an | 36 |
is mediated by a | 36 |
be found in the | 36 |
this suggests that the | 36 |
of the virus in | 36 |
as a target for | 36 |
the generation of a | 36 |
have been described in | 36 |
a role for the | 36 |
studies have demonstrated that | 36 |
play a central role | 36 |
for the recognition of | 36 |
the form of a | 36 |
for the determination of | 36 |
it is worth noting | 36 |
able to interact with | 36 |
the efficiency of the | 36 |
a significant decrease in | 36 |
are based on the | 36 |
of mhc class i | 36 |
the involvement of the | 36 |
the organization of the | 36 |
in the prefusion conformation | 36 |
the nucleus to the | 36 |
the dynamics of the | 36 |
innate and adaptive immunity | 36 |
over a period of | 36 |
and the formation of | 36 |
and western blot analysis | 36 |
that is required for | 36 |
by means of the | 36 |
of the viral rna | 36 |
acid sequence of the | 36 |
our study was to | 36 |
comparable to that of | 36 |
in addition to their | 36 |
of class i mhc | 36 |
the molecular weight of | 36 |
is crucial for the | 36 |
it has been found | 36 |
the virus life cycle | 36 |
proteins that interact with | 36 |
been shown to inhibit | 36 |
in the replication of | 36 |
of the binding site | 36 |
are thought to be | 36 |
in the control group | 36 |
in a range of | 36 |
to further investigate the | 36 |
with an increase in | 35 |
and one of the | 35 |
the m protein is | 35 |
the mechanisms involved in | 35 |
protein has been shown | 35 |
can be explained by | 35 |
was based on the | 35 |
of a protein is | 35 |
mode of action of | 35 |
of the b protein | 35 |
of the transcription factor | 35 |
in the milk of | 35 |
in relation to the | 35 |
protein encoded by the | 35 |
of some of the | 35 |
the amino acid composition | 35 |
s and s subunits | 35 |
m and e proteins | 35 |
been proposed to be | 35 |
was shown that the | 35 |
for the activation of | 35 |
has been reported in | 35 |
in the lumen of | 35 |
of the nervous system | 35 |
as is the case | 35 |
there is no evidence | 35 |
to be due to | 35 |
purification and characterization of | 35 |
complete genome sequence of | 35 |
the n protein is | 35 |
can be achieved by | 35 |
considered to be a | 35 |
histocompatibility complex class i | 35 |
of the identified proteins | 35 |
with the aim to | 35 |
members of the family | 35 |
on the level of | 35 |
of the fusion peptide | 35 |
by the formation of | 35 |
that the use of | 35 |
of each of the | 35 |
we are able to | 35 |
as shown in table | 35 |
to determine the effect | 35 |
in patients with severe | 35 |
the middle east respiratory | 35 |
a novel coronavirus from | 35 |
that are essential for | 35 |
was found in the | 35 |
based on the use | 35 |
to the study of | 35 |
a new generation of | 35 |
a number of different | 35 |
the viral spike protein | 35 |
as well as of | 35 |
supported by grants from | 35 |
the absence of any | 35 |
the release of the | 35 |
at the protein level | 35 |
the extent to which | 35 |
the control of a | 34 |
of the nucleocapsid protein | 34 |
in the human genome | 34 |
led to the identification | 34 |
the affinity of the | 34 |
were added to the | 34 |
in the immune system | 34 |
of the number of | 34 |
are shown in fig | 34 |
shown in figure a | 34 |
it was proposed that | 34 |
in the light of | 34 |
specific cd t cells | 34 |
h n influenza virus | 34 |
similar results were obtained | 34 |
by means of a | 34 |
play a significant role | 34 |
in order to evaluate | 34 |
of the influenza a | 34 |
to be related to | 34 |
in the nucleus of | 34 |
in spite of the | 34 |
hepatitis c virus replication | 34 |
has led to the | 34 |
that are associated with | 34 |
the development of an | 34 |
is determined by the | 34 |
we also found that | 34 |
has been used in | 34 |
aim of the study | 34 |
amino acid composition and | 34 |
the early stage of | 34 |
protein is required for | 34 |
understand the role of | 34 |
the mode of action | 34 |
to the site of | 34 |
the membrane of the | 34 |
the lack of a | 34 |
this is consistent with | 34 |
in order to be | 34 |
structure and dynamics of | 34 |
have also been used | 34 |
to the control group | 34 |
in an effort to | 34 |
has emerged as a | 34 |
class i mhc molecules | 34 |
in the structure of | 34 |
which is consistent with | 34 |
regulation of gene expression | 34 |
the center of the | 34 |
also be used to | 34 |
is the most abundant | 34 |
which is required for | 34 |
has also been used | 34 |
of the effects of | 34 |
important roles in the | 34 |
is similar to the | 34 |
the structure of a | 33 |
studies showed that the | 33 |
and activation of the | 33 |
to the best of | 33 |
was reported to be | 33 |
a and orf b | 33 |
may be used to | 33 |
were able to identify | 33 |
a novel class of | 33 |
is worth noting that | 33 |
the proteins in the | 33 |
best of our knowledge | 33 |
may be responsible for | 33 |
is expected to be | 33 |
one of the key | 33 |
d graphical representation of | 33 |
with that of the | 33 |
we have used a | 33 |
subcellular localization of the | 33 |
was carried out in | 33 |
in the serum of | 33 |
a number of studies | 33 |
role in the development | 33 |
the amino terminus of | 33 |
in addition to these | 33 |
were used as a | 33 |
the s ribosomal subunit | 33 |
the extracellular domain of | 33 |
of type i ifn | 33 |
a powerful tool for | 33 |
are predicted to be | 33 |
the functions of the | 33 |
of the viral envelope | 33 |
in the middle of | 33 |
a function of the | 33 |
is caused by a | 33 |
of the study was | 33 |
determine the effect of | 33 |
was to evaluate the | 33 |
of the active site | 33 |
the members of the | 33 |
it is also possible | 33 |
the interior of the | 33 |
with the formation of | 33 |
the functional role of | 33 |
could be due to | 33 |
in balb c mice | 33 |
closely related to the | 33 |
the s and s | 33 |
seems to be a | 33 |
of the murine coronavirus | 33 |
a comparison of the | 33 |
transported to the cell | 33 |
here we present a | 33 |
found to be the | 33 |
the tertiary structure of | 33 |
were isolated from the | 33 |
is to investigate the | 33 |
a web server for | 33 |
class i and class | 33 |
our aim is to | 33 |
be attributed to the | 33 |
vp vp vp vp | 33 |
of host protein synthesis | 33 |
sialic acid glycan binding | 33 |
we showed that the | 33 |
one of the best | 33 |
on the analysis of | 33 |
is a multifunctional protein | 33 |
a hidden markov model | 32 |
in the protein data | 32 |
the difference in the | 32 |
were used in the | 32 |
the past few years | 32 |
for the use of | 32 |
the relationship between the | 32 |
in the golgi complex | 32 |
proteins have been identified | 32 |
there is a need | 32 |
of different types of | 32 |
for the maintenance of | 32 |
has been found that | 32 |
in vero e cells | 32 |
were incubated for h | 32 |
the sars coronavirus nucleocapsid | 32 |
proteomic analysis of the | 32 |
are a family of | 32 |
proteins have been shown | 32 |
the open reading frame | 32 |
significant increase in the | 32 |
cells were cultured in | 32 |
was performed using a | 32 |
associated with a new | 32 |
to the pathogenesis of | 32 |
to the accumulation of | 32 |
was not affected by | 32 |
of the protein to | 32 |
the crystal structures of | 32 |
the recombinant s protein | 32 |
goal of this study | 32 |
lower than that of | 32 |
and the ability to | 32 |
of the structural proteins | 32 |
have been able to | 32 |
was used to identify | 32 |
the possible role of | 32 |
in the progression of | 32 |
cholera toxin b subunit | 32 |
the type i interferon | 32 |
in the degradation of | 32 |
and incubated for h | 32 |
found to be associated | 32 |
the best of our | 32 |
the milk of transgenic | 32 |
and its interaction with | 32 |
has proven to be | 32 |
could be detected in | 32 |
pp a and pp | 32 |
in order to develop | 32 |
open reading frame of | 32 |
been identified as a | 32 |
of these proteins in | 32 |
in the release of | 32 |
sars coronavirus e protein | 32 |
may be associated with | 32 |
is based on a | 32 |
human respiratory disease in | 32 |
even in the absence | 32 |
in the bone marrow | 32 |
required for viral replication | 32 |
forms a complex with | 32 |
confocal laser scanning microscopy | 32 |
of the human immunodeficiency | 32 |
on the host cell | 32 |
leading to the formation | 32 |
method was used to | 32 |
have been used as | 31 |
have been detected in | 31 |
the case for the | 31 |
is regulated by the | 31 |
does not appear to | 31 |
is highly expressed in | 31 |
a new coronavirus associated | 31 |
and their role in | 31 |
is characterized by the | 31 |
it is not known | 31 |
a wide spectrum of | 31 |
terminal half of the | 31 |
cysteine mutant f proteins | 31 |
new coronavirus associated with | 31 |
molecular weight of the | 31 |
has been used for | 31 |
are found in the | 31 |
has been detected in | 31 |
genome sequence of the | 31 |
a new coronavirus of | 31 |
pneumonia outbreak associated with | 31 |
also been used to | 31 |
used as a model | 31 |
entry into the host | 31 |
and transmission electron microscopy | 31 |
is necessary for the | 31 |
a common feature of | 31 |
analysis revealed that the | 31 |
is a component of | 31 |
the result of the | 31 |
to the inhibition of | 31 |
in order to improve | 31 |
western blot analysis of | 31 |
and the production of | 31 |
been suggested to be | 31 |
new coronavirus of probable | 31 |
of the mechanism of | 31 |
the spike protein is | 31 |
a potential target for | 31 |
is an urgent need | 31 |
our findings suggest that | 31 |
nucleocapsid protein of sars | 31 |
is known that the | 31 |
on the nature of | 31 |
a pneumonia outbreak associated | 31 |
analysis of the human | 31 |
through the secretory pathway | 31 |
compared to those of | 31 |
of genes involved in | 31 |
dimensional structure of the | 31 |
the m protein of | 31 |
the side chain of | 31 |
was carried out with | 31 |
the treatment of covid | 31 |
and expression of the | 31 |
the coronavirus mouse hepatitis | 31 |
the functional significance of | 31 |
to study the effect | 31 |
of the spike glycoprotein | 31 |
is located at the | 31 |
experiments were carried out | 31 |
outbreak associated with a | 31 |
have demonstrated that the | 31 |
in order to find | 31 |
by a variety of | 31 |
of amino acids and | 31 |
were washed with pbs | 31 |
does not seem to | 31 |
sera from sars patients | 31 |
the mhc class i | 31 |
the evaluation of the | 31 |
laser desorption ionization time | 31 |
the heat shock protein | 31 |
it was possible to | 31 |
the nucleotide sequence of | 31 |
with a new coronavirus | 31 |
ncov spike in the | 30 |
for the binding of | 30 |
and evolution of the | 30 |
been shown to bind | 30 |
that the number of | 30 |
are summarized in table | 30 |
the first aug codon | 30 |
been identified in the | 30 |
essential role in the | 30 |
infectious bronchitis virus e | 30 |
evolution of coronavirus spike | 30 |
were tested for their | 30 |
umbilical vein endothelial cells | 30 |
of the recombinant protein | 30 |
is not fully understood | 30 |
the objective of this | 30 |
found to be a | 30 |
was performed as described | 30 |
balb c mice were | 30 |
one or more of | 30 |
with human respiratory disease | 30 |
the pi k akt | 30 |
here we report the | 30 |
investigate the effects of | 30 |
it will be interesting | 30 |
the nucleus and the | 30 |
they are involved in | 30 |
hepatitis c virus rna | 30 |
to our understanding of | 30 |
we demonstrate that the | 30 |
were obtained from the | 30 |
the results indicated that | 30 |
the vesicular stomatitis virus | 30 |
of probable bat origin | 30 |
expression levels of the | 30 |
we propose that the | 30 |
for most of the | 30 |
part of the protein | 30 |
associated with human respiratory | 30 |
and the regulation of | 30 |
of the s subunit | 30 |
we are interested in | 30 |
spike in the prefusion | 30 |
between the nucleus and | 30 |
will be interesting to | 30 |
used for the treatment | 30 |
was detected in the | 30 |
samples were collected from | 30 |
supported in part by | 30 |
coronavirus associated with human | 30 |
with a number of | 30 |
recent studies have shown | 30 |
as a first step | 30 |
the c terminus of | 30 |
with the presence of | 30 |
of the host immune | 30 |
an inhibitor of the | 30 |
is closely related to | 30 |
the increase in the | 30 |
to act as a | 30 |
to the number of | 30 |
of the most abundant | 30 |
cell surface expression of | 30 |
has been found in | 30 |
on the type of | 30 |
was determined by the | 30 |
chronic obstructive pulmonary disease | 30 |
the intensity of the | 30 |
been suggested that the | 30 |
the role played by | 30 |
results of this study | 30 |
order to study the | 30 |
at a flow rate | 30 |
side of the membrane | 30 |
respiratory syndrome coronavirus infection | 30 |
studies are needed to | 30 |
expression and purification of | 30 |
respiratory disease in china | 30 |
of the hepatitis b | 30 |
the elucidation of the | 30 |
has been applied to | 30 |
with the development of | 30 |
coronavirus of probable bat | 30 |
of intrinsically disordered proteins | 30 |
are associated with the | 30 |
of the molecular mechanisms | 30 |
added to each well | 29 |
of the viral life | 29 |
cd t cells in | 29 |
on the activity of | 29 |
used to investigate the | 29 |
to be in the | 29 |
of action of the | 29 |
the spike protein and | 29 |
are a number of | 29 |
the potential to be | 29 |
in the inhibition of | 29 |
there are a number | 29 |
protein is involved in | 29 |
the spike glycoprotein of | 29 |
the origin of the | 29 |
an understanding of the | 29 |
the product of the | 29 |
and evolution of coronavirus | 29 |
the result of a | 29 |
it is unclear whether | 29 |
with the m protein | 29 |
on the effect of | 29 |
of molecular biology and | 29 |
a and pp ab | 29 |
interact with each other | 29 |
it was concluded that | 29 |
could serve as a | 29 |
the physiological role of | 29 |
as well as on | 29 |
of proteins that are | 29 |
antigenicity of the sars | 29 |
of the ns protein | 29 |
nucleocapsid protein of severe | 29 |
rift valley fever virus | 29 |
in the genome of | 29 |
high performance liquid chromatography | 29 |
investigated the effects of | 29 |
there is an urgent | 29 |
we focused on the | 29 |
be detected in the | 29 |
the gene of interest | 29 |
amino acid composition of | 29 |
absence and presence of | 29 |
binding sites in the | 29 |
the coronavirus spike protein | 29 |
the last few years | 29 |
were significantly higher in | 29 |
which are known to | 29 |
of the gene encoding | 29 |
of the use of | 29 |
the golgi apparatus and | 29 |
a molecular mass of | 29 |
cell leukemia virus type | 29 |
absence or presence of | 29 |
as a negative control | 29 |
structure of the n | 29 |
the sequences of the | 29 |
the primary structure of | 29 |
was associated with a | 29 |
early stages of the | 29 |
acids in cell culture | 29 |
have been made to | 29 |
amino acids in cell | 29 |
analysis of the sars | 29 |
without the need for | 29 |
that is involved in | 29 |
of the proteins in | 29 |
the context of a | 29 |
at an early stage | 29 |
glial fibrillary acidic protein | 29 |
study the role of | 29 |
hepatitis virus strain a | 29 |
the thickness of the | 29 |
i and class ii | 29 |
the important role of | 29 |
be used as an | 29 |
for the construction of | 29 |
a large variety of | 29 |
for the inhibition of | 29 |
increase in the number | 29 |
a significant reduction in | 29 |
entry of the virus | 29 |
as a model for | 29 |
of the golgi complex | 29 |
in the early stages | 29 |
a new method for | 28 |
used to analyze the | 28 |
the purpose of the | 28 |
are important for the | 28 |
of the formation of | 28 |
methods have been developed | 28 |
human parainfluenza virus type | 28 |
analysis showed that the | 28 |
not included in the | 28 |
to be crucial for | 28 |
of the unfolded protein | 28 |
might be due to | 28 |
the addition of the | 28 |
in order to avoid | 28 |
in most of the | 28 |
of a set of | 28 |
it is essential to | 28 |
of the transmembrane domain | 28 |
vg vd t cells | 28 |
involved in the pathogenesis | 28 |
we could show that | 28 |
were carried out in | 28 |
tertiary structure of the | 28 |
in cells treated with | 28 |
proteins encoded by the | 28 |
used to assess the | 28 |
of the proteins were | 28 |
of the cytoplasmic domain | 28 |
are also involved in | 28 |
cells in response to | 28 |
has been linked to | 28 |
a mutation in the | 28 |
and middle east respiratory | 28 |
and is blocked by | 28 |
viral and host proteins | 28 |
there is increasing evidence | 28 |
the development of vaccines | 28 |
for the majority of | 28 |
of the coronavirus mouse | 28 |
in a recent study | 28 |
in order to increase | 28 |
will be used to | 28 |
was used as an | 28 |
this work is to | 28 |
on the mechanism of | 28 |
were identified in the | 28 |
was found to have | 28 |
has not been reported | 28 |
that there is no | 28 |
into the lumen of | 28 |
which has been shown | 28 |
for the investigation of | 28 |
remains to be elucidated | 28 |
the expression of genes | 28 |
by an increase in | 28 |
receptor for the sars | 28 |
it is noteworthy that | 28 |
for the sars coronavirus | 28 |
of the protein was | 28 |
have been carried out | 28 |
with the addition of | 28 |
on the structure and | 28 |
the host cell membrane | 28 |
and a number of | 28 |
in the pathophysiology of | 28 |
a total of proteins | 28 |
to a variety of | 28 |
cloning and expression of | 28 |
turned out to be | 28 |
blood samples were collected | 28 |
compared to the wild | 28 |
the innate and adaptive | 28 |
the viral replication cycle | 28 |
identified in this study | 28 |
to changes in the | 28 |
in the absence and | 28 |
required for the formation | 28 |
of the wild type | 28 |
that are required for | 28 |
used to evaluate the | 28 |
plays an essential role | 28 |
in the maintenance of | 28 |
can lead to the | 28 |
the number of proteins | 28 |
known to be a | 28 |
state of the art | 28 |
study was designed to | 28 |
are part of the | 28 |
different regions of the | 28 |
in viral replication and | 28 |
for viral replication and | 28 |
a diverse set of | 28 |
by transmission electron microscopy | 28 |
some of the most | 28 |
acid sequences of the | 28 |
to test this hypothesis | 28 |
enzyme is a functional | 28 |
the addition of a | 28 |
structural characterization of the | 28 |
with regard to the | 28 |
the development of effective | 28 |
of these proteins are | 28 |
from patients with pneumonia | 28 |
a molecular weight of | 28 |
based on the analysis | 28 |
was supported by a | 28 |
that the n protein | 28 |
blocked by a clinically | 27 |
by a clinically proven | 27 |
solution structure of the | 27 |
an example of a | 27 |
the reader is referred | 27 |
in a similar manner | 27 |
of recombinant proteins in | 27 |
entry depends on ace | 27 |
patients and healthy controls | 27 |
on ace and tmprss | 27 |
influenza a virus m | 27 |
an in vitro model | 27 |
in the liver and | 27 |
the effect of different | 27 |
can be modulated by | 27 |
novel coronavirus from patients | 27 |
have been isolated from | 27 |
s d fusion protein | 27 |
in line with this | 27 |
has been identified in | 27 |
shown to be involved | 27 |
hepatitis c virus ns | 27 |
makes it possible to | 27 |
tmprss and is blocked | 27 |
during the process of | 27 |
of intrinsic disorder in | 27 |
in the absence or | 27 |
mouse hepatitis virus strain | 27 |
the strength of the | 27 |
in combination with a | 27 |
a clinically proven protease | 27 |
of some of these | 27 |
has recently been shown | 27 |
but also in the | 27 |
and adaptive immune responses | 27 |
and has been shown | 27 |
the core of the | 27 |
of porcine reproductive and | 27 |
the regulation of cell | 27 |
in the brain and | 27 |
a new family of | 27 |
depends on ace and | 27 |
sequence of the sars | 27 |
comparative analysis of the | 27 |
as can be seen | 27 |
also found to be | 27 |
the components of the | 27 |
in each of the | 27 |
is blocked by a | 27 |
ace and tmprss and | 27 |
and at the same | 27 |
was also found to | 27 |
fusion of the viral | 27 |
may be useful in | 27 |
changes in the expression | 27 |
studies are required to | 27 |
we set out to | 27 |
of programmed cell death | 27 |
the expression of cd | 27 |
by the lack of | 27 |
also involved in the | 27 |
as a negative regulator | 27 |
of the orf protein | 27 |
a model for the | 27 |
the role of autophagy | 27 |
be essential for the | 27 |
shown to bind to | 27 |
in the analysis of | 27 |
coronavirus from patients with | 27 |
used in the treatment | 27 |
have also been reported | 27 |
for the control of | 27 |
the investigation of the | 27 |
clinically proven protease inhibitor | 27 |
order to understand the | 27 |
class i fusion proteins | 27 |
study is to investigate | 27 |
cd t cells and | 27 |
it was reported that | 27 |
were incubated with the | 27 |
was inserted into the | 27 |
the shape of the | 27 |
and are involved in | 27 |
may lead to the | 27 |
and is associated with | 27 |
is the first report | 27 |
over the past years | 27 |
the study was to | 27 |
the nucleolus is a | 27 |
in this study the | 27 |
and tmprss and is | 27 |
or more of the | 27 |
and an increase in | 27 |
peptides derived from the | 27 |
breast cancer cell lines | 27 |
to be used for | 27 |
were carried out using | 27 |
it is assumed that | 27 |
dependent on the presence | 27 |
the first step of | 27 |
to a final concentration | 27 |
cell entry depends on | 27 |
on the plasma membrane | 27 |
that it is a | 27 |
different stages of the | 27 |
the porcine epidemic diarrhea | 27 |
involved in the control | 27 |
in breast cancer cells | 27 |
de novo design of | 27 |
these results show that | 27 |
the inhibitory activity of | 27 |
is encoded by the | 27 |
in response to a | 27 |
the action of the | 26 |
by interacting with the | 26 |
murine coronavirus spike protein | 26 |
the kinetics of the | 26 |
the entry of the | 26 |
the first step in | 26 |
amino acid residues of | 26 |
was no significant difference | 26 |
previous studies have shown | 26 |
and is responsible for | 26 |
it has recently been | 26 |
the presence of two | 26 |
to be one of | 26 |
is critical for the | 26 |
study the effects of | 26 |
under the same conditions | 26 |
protein was shown to | 26 |
in cd t cells | 26 |
and then incubated with | 26 |
bovine viral diarrhea virus | 26 |
committee on taxonomy of | 26 |
nucleus to the cytoplasm | 26 |
is not surprising that | 26 |
to a decrease in | 26 |
avian coronavirus infectious bronchitis | 26 |
it is not surprising | 26 |
a wide array of | 26 |
amino acid composition to | 26 |
ion channel activity of | 26 |
mouse mammary tumor virus | 26 |
the antigenicity of the | 26 |
the recognition of the | 26 |
in good agreement with | 26 |
influenza virus m protein | 26 |
for the delivery of | 26 |
to understand the mechanism | 26 |
in addition to this | 26 |
proteins were found to | 26 |
that is able to | 26 |
by the action of | 26 |
analysis was carried out | 26 |
the gene encoding the | 26 |
epidemic diarrhea virus in | 26 |
in the region of | 26 |
in order to achieve | 26 |
the surface of a | 26 |
reader is referred to | 26 |
not appear to be | 26 |
been demonstrated that the | 26 |
expression in escherichia coli | 26 |
to cd t cells | 26 |
been reported that the | 26 |
patients with pneumonia in | 26 |
with each other and | 26 |
respiratory syndrome coronavirus nsp | 26 |
the role of these | 26 |
in the life cycle | 26 |
during the development of | 26 |
the eif f complex | 26 |
has been demonstrated in | 26 |
to severe acute respiratory | 26 |
has been used as | 26 |
influenza a virus ns | 26 |
in the lipid bilayer | 26 |
the establishment of a | 26 |
we investigated the effect | 26 |
mechanisms involved in the | 26 |
was used to predict | 26 |
which leads to the | 26 |
the free energy of | 26 |
or in combination with | 26 |
the results of our | 26 |
can act as a | 26 |
high density multiepitope protein | 26 |
with pneumonia in china | 26 |
the m proton channel | 26 |
cells in the presence | 26 |
in the search for | 26 |
it is based on | 26 |
international committee on taxonomy | 26 |
is caused by the | 26 |
included in this study | 26 |
in contact with the | 26 |
method is based on | 26 |
and in some cases | 26 |
were significantly higher than | 26 |
that some of the | 26 |
be the result of | 26 |
to investigate the effects | 26 |
of the membrane protein | 26 |
has been described in | 26 |
it is not yet | 26 |
respiratory syndrome coronavirus a | 26 |
in the viral life | 26 |
on taxonomy of viruses | 26 |
and dynamics of the | 26 |
the difference between the | 26 |
of the viral protein | 26 |
can be attributed to | 26 |
on the cytoplasmic side | 26 |
and stability of the | 26 |
of transmissible gastroenteritis virus | 26 |
these observations suggest that | 26 |
have been linked to | 26 |
the time course of | 26 |
of differentially expressed proteins | 26 |
the significance of the | 26 |
is a powerful tool | 26 |
was also shown to | 26 |
acid composition to predict | 25 |
of the capsid protein | 25 |
play key roles in | 25 |
in this study were | 25 |
are expected to be | 25 |
has shown that the | 25 |
using a variety of | 25 |
of proteins from the | 25 |
as a means to | 25 |
development of a new | 25 |
involved in regulation of | 25 |
to the end of | 25 |
by size exclusion chromatography | 25 |
the n terminus of | 25 |
of the virus and | 25 |
has no effect on | 25 |
to the nucleus and | 25 |
be part of the | 25 |
this article can be | 25 |
known to interact with | 25 |
t cells in the | 25 |
were analyzed by sds | 25 |
of the cytoplasmic tail | 25 |
have no competing interests | 25 |
in our understanding of | 25 |
the hypothesis that the | 25 |
are presented in table | 25 |
with the ability to | 25 |
in the accumulation of | 25 |
of the viral replication | 25 |
converting enzyme is a | 25 |
compared to wild type | 25 |
local alignment search tool | 25 |
which is based on | 25 |
for the characterization of | 25 |
of the two proteins | 25 |
to the cytoplasm and | 25 |
to the immune system | 25 |
respiratory syndrome coronavirus replication | 25 |
have been described to | 25 |
has a role in | 25 |
cloning and characterization of | 25 |
is able to bind | 25 |
the value of the | 25 |
that are known to | 25 |
are involved in a | 25 |
of a range of | 25 |
as a receptor for | 25 |
this research was supported | 25 |
taking advantage of the | 25 |
but it is not | 25 |
for the discovery of | 25 |
the fusion of the | 25 |
at amplitude for min | 25 |
the endoplasmic reticulum to | 25 |
in order to further | 25 |
also referred to as | 25 |
conformational change in the | 25 |
as part of a | 25 |
a new approach to | 25 |
induce the formation of | 25 |
we are currently investigating | 25 |
can serve as a | 25 |
is a receptor for | 25 |
and molecular dynamics simulations | 25 |
been found in the | 25 |
is the fact that | 25 |
has been carried out | 25 |
in the present paper | 25 |
as a tool for | 25 |
reading of the manuscript | 25 |
the catalytic domain of | 25 |
the absence and presence | 25 |
of the protein of | 25 |
antigen processing and presentation | 25 |
to the release of | 25 |
of low molecular weight | 25 |
a major component of | 25 |
internal initiation of translation | 25 |
end of the genome | 25 |
with a focus on | 25 |
in the past few | 25 |
an important role of | 25 |
which is one of | 25 |
structural proteins of the | 25 |
further studies are required | 25 |
are not well understood | 25 |
these results indicated that | 25 |
supported by a grant | 25 |
essential for viral replication | 25 |
an important role for | 25 |
can be detected in | 25 |
has also been proposed | 25 |
was to determine the | 25 |
been the subject of | 25 |
to the understanding of | 25 |
which is characterized by | 25 |
were used to determine | 25 |
to the regulation of | 25 |
as an alternative to | 25 |
in the s subunit | 25 |
the vicinity of the | 25 |
we have been able | 25 |
been proposed that the | 25 |
in any of the | 25 |
as an inhibitor of | 25 |
compared with the control | 25 |
which acts as a | 25 |
are consistent with the | 25 |
and found that the | 25 |
the yield of the | 25 |
infectious bursal disease virus | 25 |
to their ability to | 25 |
cytoplasmic domain of the | 25 |
by flow cytometry and | 25 |
at the university of | 25 |
a major cause of | 25 |
is a type i | 25 |
cells were grown in | 25 |
to be important in | 25 |
with rna chaperone activity | 25 |
of the in vitro | 25 |
this study aimed to | 25 |
were included in the | 25 |
for the assessment of | 25 |
and their interactions with | 25 |
article can be found | 25 |
in complex with the | 25 |
active site of the | 25 |
that interact with the | 25 |
cytoplasmic tail of the | 25 |
work is supported by | 25 |
well as for the | 25 |
in the immune response | 25 |
is a prerequisite for | 25 |
internal ribosomal entry site | 25 |
that are responsible for | 25 |
nucleus and the cytoplasm | 25 |
at an moi of | 25 |
at room temperature in | 25 |
structural and functional characterization | 25 |
the discovery of a | 25 |
it is involved in | 25 |
of the fact that | 25 |
in the cytoplasmic tail | 25 |
are among the most | 24 |
sonication at amplitude for | 24 |
translation initiation factor eif | 24 |
is likely that the | 24 |
studied the effect of | 24 |
involved in the interaction | 24 |
of newcastle disease virus | 24 |
the pathogenesis of the | 24 |
protein interaction map reveals | 24 |
the role of a | 24 |
been developed for the | 24 |
basis for the recognition | 24 |
de haan et al | 24 |
be useful in the | 24 |
are members of the | 24 |
is a potent inhibitor | 24 |
may act as a | 24 |
for the isolation of | 24 |
we have analyzed the | 24 |
plasma membrane of the | 24 |
to a number of | 24 |
in the diagnosis of | 24 |
are characterized by the | 24 |
our data demonstrate that | 24 |
no significant difference in | 24 |
the removal of the | 24 |
the disruption of the | 24 |
is a common feature | 24 |
they have no competing | 24 |
a portion of the | 24 |
the degradation of the | 24 |
and analysis of the | 24 |
through the activation of | 24 |
within the context of | 24 |
of science and technology | 24 |
the differences between the | 24 |
the enzymatic activity of | 24 |
can be seen in | 24 |
national center for biotechnology | 24 |
results indicated that the | 24 |
here we present the | 24 |
this study we have | 24 |
the catalytic activity of | 24 |
in such a way | 24 |
was identified as the | 24 |
the immune system and | 24 |
an e ubiquitin ligase | 24 |
the most abundant protein | 24 |
our data indicate that | 24 |
terminal end of the | 24 |
sequences have been identified | 24 |
is expressed in the | 24 |
as a marker of | 24 |
it is shown that | 24 |
this work is supported | 24 |
biological activity of the | 24 |
we have identified a | 24 |
to one of the | 24 |
the orientation of the | 24 |
the rational design of | 24 |
endoplasmic reticulum to the | 24 |
also play a role | 24 |
heterogeneous nuclear ribonucleoprotein a | 24 |
for binding to the | 24 |
alone or in combination | 24 |
before and after the | 24 |
is yet to be | 24 |
we focus on the | 24 |
in the last decade | 24 |
might play a role | 24 |
the selection of the | 24 |
a large proportion of | 24 |
and to a lesser | 24 |
tables s and s | 24 |
be used to study | 24 |
of epidermal growth factor | 24 |
supported by the national | 24 |
induction of apoptosis in | 24 |
were performed using the | 24 |
the cells were washed | 24 |
cells infected with the | 24 |
been used for the | 24 |
regulates the expression of | 24 |
the discovery of novel | 24 |
cells were fixed with | 24 |
the protein composition of | 24 |
the purity of the | 24 |
in the cytoplasmic domain | 24 |
appears to be the | 24 |
on the number of | 24 |
the time of writing | 24 |
which is essential for | 24 |
found to be highly | 24 |
data indicate that the | 24 |
supported by the russian | 24 |
molecular biology of coronaviruses | 24 |
the epidermal growth factor | 24 |
in the sera of | 24 |
is an integral membrane | 24 |
molecular mass of kda | 24 |
tumor necrosis factor alpha | 24 |
was approved by the | 24 |
the class i mhc | 24 |
is transported to the | 24 |
a number of proteins | 24 |
immunization of mice with | 24 |
significant difference between the | 24 |
basic local alignment search | 24 |
of the p protein | 24 |
structure and mechanism of | 24 |
to be mediated by | 24 |
in the evolution of | 24 |
which is present in | 24 |
have been demonstrated to | 24 |
a number of other | 24 |
are located within the | 24 |
are the most common | 24 |
the induction of the | 24 |
been shown to induce | 24 |
are similar to those | 24 |
were selected for further | 24 |
cells transfected with the | 24 |
of patients infected with | 24 |
it is expected that | 24 |
of one or more | 24 |
of the activity of | 24 |
and mouth disease virus | 24 |
the cell surface of | 24 |
have been observed in | 24 |
the appearance of a | 24 |
chinese hamster ovary cells | 24 |
reported in the literature | 24 |
have also been shown | 24 |
the observation that the | 24 |
the structures of the | 24 |
is released from the | 24 |
acid residues in the | 24 |
was supported by grant | 24 |
objective of this study | 24 |
a large amount of | 24 |
referred to as the | 24 |
the present work we | 24 |
representation of protein sequences | 24 |
and their ability to | 24 |
proteins targeted by sars | 23 |
to the generation of | 23 |
it can be concluded | 23 |
that is essential for | 23 |
the key role of | 23 |
room temperature for min | 23 |
domain of the spike | 23 |
that the formation of | 23 |
from the analysis of | 23 |
breast cancer cell line | 23 |
and the absence of | 23 |
by mutations in the | 23 |
at the interface of | 23 |
not seem to be | 23 |
into the role of | 23 |
a significant increase of | 23 |
for a period of | 23 |
envelope protein ion channel | 23 |
that binds to the | 23 |
would be expected to | 23 |
were expressed in e | 23 |
peptides corresponding to the | 23 |
purification of recombinant proteins | 23 |
is composed of a | 23 |
spike protein is a | 23 |
coronavirus envelope protein ion | 23 |
of the interactions between | 23 |
about the role of | 23 |
as shown by the | 23 |
is not yet known | 23 |
the fact that it | 23 |
it is conceivable that | 23 |
of the function of | 23 |
in the modulation of | 23 |
protein of the sars | 23 |
as well as some | 23 |
with respect to their | 23 |
the creative commons attribution | 23 |
of scov e protein | 23 |
for hepatitis c virus | 23 |
crystal structures of the | 23 |
that the protein is | 23 |
for recombinant protein production | 23 |
amino acid residues and | 23 |
in the human body | 23 |
to the cell membrane | 23 |
when compared with the | 23 |
there has been a | 23 |
we have recently shown | 23 |
in a murine model | 23 |
the immunogenicity of the | 23 |
in the use of | 23 |
from the cytoplasm to | 23 |
design and synthesis of | 23 |
to the wild type | 23 |
that could be used | 23 |
proteins such as the | 23 |
this indicates that the | 23 |
of murine hepatitis virus | 23 |
the activity of a | 23 |
structure of the human | 23 |
the identification of novel | 23 |
we demonstrated that the | 23 |
may be used as | 23 |
in the biosynthesis of | 23 |
to study the role | 23 |
transmembrane domain of the | 23 |
natural science foundation of | 23 |
was determined using the | 23 |
the protective effect of | 23 |
physicochemical properties of the | 23 |
is due to a | 23 |
the endoplasmic reticulum membrane | 23 |
terminal amino acids of | 23 |
conformational changes of the | 23 |
the intracellular localization of | 23 |
pivotal role in the | 23 |
of the creative commons | 23 |
has yet to be | 23 |
simplex virus type infection | 23 |
graphical representation of protein | 23 |
the results of these | 23 |
the design of new | 23 |
of african swine fever | 23 |
of the sars virus | 23 |
each of the three | 23 |
contribute to the development | 23 |
of the sars cov | 23 |
mrna and protein expression | 23 |
in contrast to other | 23 |
to gain insight into | 23 |
the green fluorescent protein | 23 |
to be dependent on | 23 |
tumor necrosis factor receptor | 23 |
type i and type | 23 |
in vascular smooth muscle | 23 |
the design of a | 23 |
rats were divided into | 23 |
one of the important | 23 |
by western blot and | 23 |
a variety of cellular | 23 |
with fetal bovine serum | 23 |
of the actin cytoskeleton | 23 |
in the loss of | 23 |
it has not been | 23 |
and the lack of | 23 |
the start of the | 23 |
of protein synthesis in | 23 |
authors would like to | 23 |
in the early s | 23 |
the therapeutic potential of | 23 |
binding site in the | 23 |
will focus on the | 23 |
of this class of | 23 |
with a view to | 23 |
in the past years | 23 |
the distance between the | 23 |
requires the presence of | 23 |
a vital role in | 23 |
has been attributed to | 23 |
the early phase of | 23 |
the presence of high | 23 |
an urgent need to | 23 |
is not sufficient to | 23 |
found to interact with | 23 |
it seems likely that | 23 |
bronchitis virus e protein | 23 |
the absence or presence | 23 |
from the severe acute | 23 |
proteins with rna chaperone | 23 |
target for the development | 23 |
these data demonstrate that | 23 |
to understand the role | 23 |
as a marker for | 23 |
we observed that the | 23 |
as a starting point | 23 |
of the g protein | 23 |
authors declare no competing | 23 |
mrna and protein levels | 23 |
in order to test | 23 |
by the immune system | 22 |
classical swine fever virus | 22 |
as a template for | 22 |
for the interaction with | 22 |
a key regulator of | 22 |
is also able to | 22 |
of heat shock protein | 22 |
compared with that of | 22 |
type i ifn signaling | 22 |
understand the mechanism of | 22 |
different from that of | 22 |
from the er membrane | 22 |
been used as a | 22 |
amino acid sequence identity | 22 |
rna was extracted from | 22 |
the cleavage of the | 22 |
by the induction of | 22 |
that the binding of | 22 |
the morphology of the | 22 |
porcine transmissible gastroenteritis virus | 22 |
the differences in the | 22 |
of the infected cells | 22 |
the way in which | 22 |
the accuracy of the | 22 |
the first time the | 22 |
the identity of the | 22 |
experiments were performed in | 22 |
of gene expression in | 22 |
are more likely to | 22 |
the golgi complex and | 22 |
in the culture medium | 22 |
could be used in | 22 |
of the proteins identified | 22 |
the first and second | 22 |
of the gastrointestinal tract | 22 |
that the amount of | 22 |
the importance of this | 22 |
have been suggested to | 22 |
the er and golgi | 22 |
the impact of the | 22 |
and the activation of | 22 |
and structural characterization of | 22 |
evs were isolated by | 22 |
been used in the | 22 |
on the production of | 22 |
been used to study | 22 |
has the ability to | 22 |
or s t protein | 22 |
able to bind to | 22 |
is targeted to the | 22 |
blood samples were taken | 22 |
the coronavirus nucleocapsid protein | 22 |
to the role of | 22 |
there were no significant | 22 |
that one of the | 22 |
it is tempting to | 22 |
proteins that are involved | 22 |
van der waals interactions | 22 |
it can be used | 22 |
which are responsible for | 22 |
of human papillomavirus type | 22 |
several lines of evidence | 22 |
in the venom of | 22 |
for the purification of | 22 |
article distributed under the | 22 |
the cells were then | 22 |
the murine coronavirus spike | 22 |
class i and ii | 22 |
results are consistent with | 22 |
by the expression of | 22 |
the dna damage response | 22 |
was similar to that | 22 |
the hydrophobic thickness of | 22 |
of the same protein | 22 |
been identified by blast | 22 |
described in the literature | 22 |
is considered as a | 22 |
the e protein of | 22 |
analysis of the protein | 22 |
it has been postulated | 22 |
nucleocapsid protein of the | 22 |
on the n protein | 22 |
studies have suggested that | 22 |
is limited by the | 22 |
of the porcine epidemic | 22 |
viral rna synthesis and | 22 |
it is thought that | 22 |
the replication of the | 22 |
the host cell surface | 22 |
involved in this process | 22 |
vesicular stomatitis virus g | 22 |
are found to be | 22 |
the contents of the | 22 |
the cytoplasmic tails of | 22 |
significant role in the | 22 |
has been supported by | 22 |
identified by mass spectrometry | 22 |
the physicochemical properties of | 22 |
to that observed in | 22 |
of each amino acid | 22 |
are a group of | 22 |
to localize to the | 22 |
was supported in part | 22 |
is derived from the | 22 |
that has been shown | 22 |
the aim is to | 22 |
the national center for | 22 |
in a wide variety | 22 |
the proteins of the | 22 |
may play an important | 22 |
could not be detected | 22 |
protein sequences based on | 22 |
was calculated using the | 22 |
access article distributed under | 22 |
an essential component of | 22 |
to a family of | 22 |
statistical analysis was performed | 22 |
have focused on the | 22 |
distributed under the terms | 22 |
resulting in the formation | 22 |
as the number of | 22 |
used to measure the | 22 |
and size exclusion chromatography | 22 |
in polarized epithelial cells | 22 |
and the effects of | 22 |
order to evaluate the | 22 |
of human serum albumin | 22 |
were washed twice with | 22 |
the correlation between the | 22 |
the function of these | 22 |
the early secretory pathway | 22 |
in a rat model | 22 |
the case of a | 22 |
to determine if the | 22 |
were used to identify | 22 |
to study the effects | 22 |
is in contrast to | 22 |
in the processing of | 22 |
endoplasmic reticulum stress and | 22 |
with the control group | 22 |
and in the presence | 22 |
from a patient with | 22 |
to address this issue | 22 |
were also able to | 22 |
was also observed in | 22 |
through the nuclear pore | 22 |
as a therapeutic target | 22 |
the presence of both | 22 |
between the er and | 22 |
the design of novel | 22 |
the international committee on | 22 |
mutational analysis of the | 22 |
probably due to the | 22 |
wild type and mutant | 22 |
of the viral and | 22 |
was carried out to | 22 |
according to our results | 22 |
is proportional to the | 22 |
the er and the | 22 |
was determined to be | 22 |
hepatitis b virus x | 22 |