trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
mouse hepatitis virus	1337
of mouse hepatitis	536
the presence of	400
as well as	328
central nervous system	282
murine hepatitis virus	243
q q q	240
of the coronavirus	237
of the mhv	231
the absence of	223
the role of	218
severe acute respiratory	206
acute respiratory syndrome	203
the n protein	198
infectious bronchitis virus	196
in the presence	185
cd t cells	184
data not shown	181
mice infected with	180
end of the	177
the s protein	174
hepatitis virus strain	171
in the absence	170
of the virus	165
infected with mhv	163
been shown to	161
of murine coronavirus	158
analysis of the	156
of the viral	155
the central nervous	155
the murine coronavirus	153
it has been	153
in the cns	152
respiratory syndrome coronavirus	150
the development of	144
has been shown	144
the expression of	142
feline infectious peritonitis	141
of the s	140
balb c mice	140
the number of	134
of the murine	134
the m protein	133
of the genome	133
a number of	132
of the n	132
coronavirus mouse hepatitis	130
viral rna synthesis	128
in order to	123
the pathogenesis of	122
were infected with	121
has not been	121
as previously described	118
c bl mice	117
the formation of	116
in the liver	113
in addition to	113
type i ifn	111
the ability of	110
due to the	110
region of the	108
the cells were	106
cells infected with	106
one of the	105
in the brain	105
in the s	103
infection of the	103
in contrast to	102
at room temperature	102
a and b	101
the effect of	99
has also been	97
strains of mice	96
a variety of	96
expression of the	96
in infected cells	95
in response to	95
hepatitis virus type	95
in this study	95
consistent with the	94
shown in fig	94
nsp and nsp	94
the s gene	93
is required for	92
at h p	91
virus strain a	91
is associated with	91
according to the	91
the end of	91
appears to be	90
as shown in	90
was used to	89
observed in the	89
of viral rna	88
for min at	88
the synthesis of	88
in the mhv	87
strains of mhv	86
hepatitis virus infection	85
the golgi complex	85
structure of the	85
for h at	84
transmissible gastroenteritis virus	84
cells in the	84
in vitro and	83
the amount of	83
hepatitis virus a	83
of the mouse	83
cells were infected	83
the induction of	82
as described previously	82
coronavirus spike protein	81
shown to be	81
all of the	81
found to be	81
of the spike	80
identification of a	79
sequence of the	79
part of the	79
in cell culture	79
avian infectious bronchitis	78
open reading frame	78
the production of	78
of infected cells	78
to determine the	78
associated with the	77
of murine hepatitis	77
strand rna synthesis	77
to mouse hepatitis	77
of the cns	76
the spinal cord	76
involved in the	75
mhv h a	75
dependent rna polymerase	75
a role in	74
the site of	74
the use of	74
present in the	74
processing of the	73
the cell surface	73
the effects of	73
characterization of a	73
role in the	73
has been reported	73
was found to	73
the course of	72
the immune response	72
the genomic rna	72
characterization of the	72
in the golgi	72
the plasma membrane	71
on the other	71
and characterization of	70
the spike protein	70
it is not	70
to that of	69
an important role	69
of the e	69
m and s	68
the mechanism of	68
the other hand	68
dn t cells	68
with mouse hepatitis	68
of the protein	67
some of the	67
murine coronavirus spike	67
the e protein	67
have shown that	67
as a result	67
mutations in the	66
the importance of	66
role of the	66
suggest that the	66
the lack of	65
of the m	65
most of the	65
have not been	65
found in the	65
infection in mice	65
in the central	65
cells of the	65
the fact that	64
to be the	64
in which the	64
in the mouse	63
it is possible	63
members of the	63
is consistent with	63
cd t cell	63
showed that the	62
appeared to be	62
of severe acute	62
we found that	62
responsible for the	62
in the cytoplasm	62
of mhv infection	62
and in the	62
in the same	61
the nucleocapsid protein	61
the level of	61
of the nsp	61
was observed in	60
and in vitro	60
infection with mhv	60
regions of the	60
similar to that	60
the spike glycoprotein	60
infection in the	60
the majority of	59
lymphocytic choriomeningitis virus	59
in mice infected	59
detected in the	59
national research council	58
a murine coronavirus	58
strain of mhv	58
of the sars	58
suggesting that the	58
the addition of	58
is possible that	58
a result of	58
the ability to	58
member of the	58
coronavirus infectious bronchitis	57
differences in the	57
domain of the	57
have been shown	57
of the rna	57
has been demonstrated	57
based on the	57
the e glycoprotein	57
balb c and	57
to be a	57
the leader rna	57
the case of	56
similar to the	56
in the spike	56
comparison of the	56
been shown that	56
resulted in a	56
cd c t	56
the golgi apparatus	56
well as the	55
cleavage of the	55
were used to	55
data suggest that	55
by mouse hepatitis	55
into the cns	55
infectious peritonitis virus	55
to determine whether	55
as compared to	54
of the ga	54
infected with a	54
derived from the	54
could not be	54
downstream of the	54
the present study	54
was added to	54
was determined by	54
s and s	54
the cns of	54
the evolution of	54
the coronavirus mouse	54
targeted rna recombination	53
alb ts icv	53
be used to	53
in the case	53
of laboratory mice	53
the severe acute	53
monoclonal antibodies to	53
be involved in	53
virus in the	53
virus of mice	53
the replication of	53
of infectious virus	52
the virus is	52
the s glycoprotein	52
the genome of	52
vitro and in	52
of mice with	52
the brains of	52
polymerase chain reaction	52
that of the	52
of the brain	52
infection of mice	52
related to the	52
depending on the	52
can be used	52
the immune system	51
cells were washed	51
play a role	51
appear to be	51
in vivo and	51
infected cells were	51
the viral genome	51
contribute to the	51
remains to be	51
not essential for	51
by plaque assay	50
virus infection in	50
used as a	50
of feline infectious	50
the mhv genome	50
was shown to	50
was detected in	50
added to the	50
makino et al	50
important role in	50
in laboratory mice	50
is thought to	50
the generation of	50
type i interferon	50
to determine if	50
virus replication in	50
have also been	50
in immunodeficient mice	49
a j mice	49
of the leader	49
compared to the	49
response to mhv	49
in tissue culture	49
a member of	49
the endoplasmic reticulum	49
of the immune	49
t cells in	49
the structure of	48
of a novel	48
an moi of	48
such as the	48
formation of the	48
multiplicity of infection	48
stohlman et al	48
the leader sequence	48
be due to	48
results suggest that	48
at an moi	48
in balb c	48
sequence analysis of	48
the orf a	48
amino acid sequence	48
of multiple sclerosis	48
in immunocompetent mice	48
replication and transcription	48
of a murine	47
of type i	47
the viral rna	47
is responsible for	47
shown in figure	47
of a coronavirus	47
infected cells and	47
suggested that the	47
immune response to	47
herpes simplex virus	47
is not known	47
and spinal cord	47
were found to	47
defective interfering rna	47
the mouse hepatitis	46
a neurotropic coronavirus	46
at the end	46
human coronavirus e	46
c t cells	46
in viral rna	46
of the gene	46
in the spinal	46
were obtained from	46
between the two	46
was supported by	46
and in vivo	46
considered to be	46
of the golgi	46
of viral antigen	46
cells were incubated	46
the binding of	45
laboratory animal medicine	45
of the central	45
at day p	45
of the disease	45
virus replication and	45
in cells infected	45
the context of	45
strain of mouse	45
of the host	45
s glycoprotein gene	45
the viral envelope	45
may also be	45
can be detected	45
in the present	45
there is a	44
replication in the	44
demonstrated that the	44
identification of the	44
the detection of	44
the study of	44
within the cns	44
prevention and control	44
changes in the	44
located in the	44
similar to those	44
there is no	44
a role for	44
were determined by	44
but not in	44
interaction between the	44
were incubated with	44
class i expression	43
are susceptible to	43
the sequence of	43
to mhv infection	43
the severity of	43
isolated from the	43
is not essential	43
half of the	43
the regulation of	43
materials and methods	43
a mouse hepatitis	43
terminal domain of	43
in the pathogenesis	43
been reported to	43
transmissible gastroenteritis coronavirus	43
presence of the	43
a model for	43
sensitive mutants of	43
dbt cells were	43
have been described	43
the extent of	42
vesicular stomatitis virus	42
have been identified	42
in the infected	42
t cells are	42
cd and cd	42
in the n	42
c h mice	42
lavi et al	42
a and mhv	42
contrast to the	42
molecular biology of	42
as a model	41
may not be	41
liu et al	41
the he protein	41
of rnase l	41
in the context	41
likely to be	41
the appearance of	41
knobler et al	41
the molecular biology	41
the structural proteins	41
is dependent on	41
the amino acid	41
suggests that the	41
is mediated by	41
of a new	41
viral replication in	41
coronavirus nonstructural protein	41
the host cell	41
and incubated for	41
were treated with	41
of the infection	41
been detected in	41
is essential for	41
the mhv receptor	40
the results of	40
vivo and in	40
wege et al	40
the time of	40
are shown in	40
each of the	40
were observed in	40
is characterized by	40
the outcome of	40
mhv infection in	40
snijder et al	40
the brain and	40
mice were inoculated	40
de haan et	40
haan et al	40
demyelination induced by	40
i i i	40
hepatitis c virus	40
of murine coronaviruses	39
was carried out	39
of the human	39
be found in	39
because of the	39
the control of	39
and cd t	39
mhv infection of	39
terminus of the	39
of infant mice	39
as described above	39
the in vitro	39
cells were then	39
of infected mice	39
mhc class i	39
results indicate that	39
susceptibility to mhv	39
a multiplicity of	39
of the cells	39
of the two	39
of hnrnp a	38
are involved in	38
p and p	38
found that the	38
the surface of	38
of n protein	38
for mouse hepatitis	38
ability of the	38
of t cells	38
thought to be	38
protein is a	38
hepatitis virus is	38
can also be	38
wk of age	38
of these viruses	38
and has been	38
viral antigen was	38
of sars coronavirus	38
for up to	38
the mhv s	38
infected with the	38
of the genomic	37
not required for	37
portion of the	37
infected with mouse	37
strand rna viruses	37
with respect to	37
the function of	37
siddell et al	37
a combination of	37
indicating that the	37
murine coronavirus mhv	37
the identification of	37
were stained with	37
indicate that the	37
s protein is	37
the virus to	37
chen et al	37
activity of the	37
mutants of mouse	37
m s complexes	37
an increase in	37
were able to	37
shown that the	37
at d p	36
not yet been	36
their ability to	36
associated with a	36
the spike gene	36
for viral replication	36
luytjes et al	36
for detection of	36
virus titers in	36
coronavirus defective interfering	36
development of a	36
to the cell	36
referred to as	36
in infant mice	36
which is the	36
experimental infection of	36
in viral replication	36
there was no	36
is not clear	36
be detected in	36
high levels of	36
biology of coronaviruses	36
gene of the	36
is involved in	36
rottier et al	35
the prevalence of	35
the coronavirus mhv	35
c and c	35
as early as	35
the possibility that	35
of orf a	35
of the orf	35
brain and spinal	35
t cells and	35
resulted in the	35
percy and barthold	35
adoptive transfer of	35
this work was	35
the result of	35
the infected cells	35
and expression of	35
of the polymerase	35
coronavirus nucleocapsid protein	35
murine coronavirus mouse	35
fleming et al	35
gorbalenya et al	35
at a multiplicity	35
to study the	35
gene encoding the	35
of the membrane	35
of mice and	35
in the viral	34
with the viral	34
knoops et al	34
seen in the	34
interactions between the	34
in the brains	34
the di rna	34
of coronavirus infection	34
to investigate the	34
as described in	34
the cytoplasm of	34
studies on the	34
the nasal mucosa	34
and may be	34
open reading frames	34
was used as	34
this suggests that	34
mouse hepatitis coronavirus	34
incubated for h	34
mice and rats	34
to examine the	34
following mhv infection	34
a series of	34
be differentiated from	34
linked immunosorbent assay	34
understanding of the	34
during the first	34
have been reported	34
these data suggest	34
the basis of	34
with or without	34
some of these	34
parts of the	34
days post infection	33
at the time	33
lee et al	33
coronavirus rna synthesis	33
is based on	33
the cleavage site	33
upstream of the	33
in mouse hepatitis	33
for the detection	33
to interact with	33
to the mhv	33
binding to the	33
a strain of	33
the assembly of	33
did not affect	33
orf a and	33
at the non	33
and c bl	33
depends on the	33
could be detected	33
function of the	33
is not required	33
activation of the	33
at days post	33
specificity of the	33
virus from the	33
bind to the	33
study of the	33
of e l	33
amino acid substitutions	33
for at least	33
in agreement with	33
of the virion	32
the type i	32
were analyzed by	32
of mhv and	32
of the most	32
are known to	32
were carried out	32
obtained from the	32
proteins of the	32
dependent on the	32
followed by a	32
murine coronavirus jhm	32
in the coronavirus	32
results in a	32
viral replication and	32
is the most	32
kindly provided by	32
with the exception	32
to the golgi	32
the sars virus	32
c bl and	32
vennema et al	32
and incubated at	32
that had been	32
is supported by	32
rna synthesis and	32
of coronavirus mhv	32
of s a	32
was able to	32
c for min	32
of transmissible gastroenteritis	32
possible that the	32
holmes et al	32
the liver and	32
of rna synthesis	32
the recombinant viruses	32
the a strain	31
the replicase gene	31
the e l	31
mutation in the	31
b and c	31
c bl j	31
was performed using	31
is shown in	31
studies have shown	31
may be a	31
may contribute to	31
of virus infection	31
is a major	31
be detected by	31
fetal bovine serum	31
the inhibition of	31
ziebuhr et al	31
the acute phase	31
mhv s protein	31
of cd c	31
supported by the	31
proteolytic cleavage of	31
in association with	31
in c bl	31
to be involved	31
that the n	31
revealed that the	31
s h d	31
structural proteins of	31
that have been	31
it is also	31
the accumulation of	31
in the nasal	31
c h hej	31
to those of	31
the distribution of	31
is likely to	30
used to detect	30
major histocompatibility complex	30
corresponding to the	30
influenza a virus	30
mesenteric lymph nodes	30
m and e	30
on the basis	30
the potential for	30
of dbt cells	30
that the virus	30
of viral replication	30
expression of a	30
dveksler et al	30
replication of the	30
rna synthesis in	30
mouse hepatitis viruses	30
to the plasma	30
residues in the	30
of the recombinant	30
properties of the	30
of avian infectious	30
the existence of	30
sawicki et al	30
of coronavirus mouse	30
protein of mhv	30
the pattern of	30
foxn nu mice	30
we have previously	30
persistently infected with	30
specific cd t	30
the sars coronavirus	30
play an important	30
mutants of mhv	30
type i ifns	30
localization of the	30
work was supported	30
hepatitis virus in	30
gallagher et al	30
virus can be	30
for min and	29
susceptible to infection	29
is known to	29
of the three	29
prkdc scid mice	29
with that of	29
hepatitis b virus	29
can occur in	29
n protein and	29
of balb c	29
of mice to	29
of human coronavirus	29
in multiple sclerosis	29
h after infection	29
in suckling mice	29
of the same	29
must be differentiated	29
the kinetics of	29
in the formation	29
the efficiency of	29
s gene of	29
mhv rna synthesis	29
washed three times	29
the polymerase gene	29
of virus replication	29
n protein is	29
used in this	29
presence of a	29
to viral infection	29
are required for	29
in dbt cells	29
the loss of	29
persistent infection in	29
hepatitis virus from	29
protein in the	29
mhv n protein	29
it should be	29
as determined by	29
demyelination in the	29
influenza c virus	29
the release of	29
these results suggest	29
is not a	29
of the first	29
many of the	29
and h p	29
increase in the	29
the nature of	29
were shown to	29
the virus was	29
replication of mhv	29
the interaction between	28
in the rat	28
for virus replication	28
has been proposed	28
of mice infected	28
the involvement of	28
identification and characterization	28
the initiation of	28
sarma et al	28
g for min	28
of bovine coronavirus	28
was used for	28
expression in the	28
of the replicase	28
e glycoprotein of	28
was associated with	28
proteolytic processing of	28
the observation that	28
are associated with	28
total number of	28
after infection with	28
in the spleen	28
any of the	28
interaction with the	28
is not yet	28
the orf b	28
the mhv n	28
cells within the	28
of m and	28
and rna synthesis	28
n protein was	28
the carcinoembryonic antigen	28
of viral proteins	28
the virus and	28
the total number	28
it may be	28
the interaction of	28
it is important	28
of infection in	28
the n gene	28
in combination with	28
a group of	28
required for the	28
of the cleavage	28
of subgenomic mrnas	28
to understand the	28
viral antigen in	28
activity in the	27
been reported in	27
t cell clones	27
alb ts and	27
positive cells were	27
to the n	27
t cells were	27
the s subunit	27
middle east respiratory	27
virus strain jhm	27
determined by plaque	27
of coronavirus rna	27
addition to the	27
baker et al	27
lai et al	27
rna polymerase activity	27
is an important	27
in this region	27
the spread of	27
of cd t	27
on the surface	27
days after infection	27
s protein of	27
were washed with	27
size of the	27
washed with pbs	27
in rna synthesis	27
rna replication and	27
of the c	27
closely related to	27
in the cell	27
and that the	27
baric et al	27
the m and	27
cells were harvested	27
nature of the	27
of mhv rna	27
of which are	27
the human coronavirus	27
of the structural	27
to infection by	27
with a neurotropic	27
demyelination in mice	27
in nude mice	27
sawicki and sawicki	27
of infectious bronchitis	27
region in the	27
in the usa	27
human immunodeficiency virus	27
during the course	27
to bind to	27
of a neurotropic	27
the activation of	27
of genomic rna	27
t cell responses	26
the exception of	26
in situ hybridization	26
one or more	26
in the current	26
were subjected to	26
the ea fraction	26
h at room	26
of the nucleocapsid	26
be required for	26
the mechanisms of	26
been associated with	26
of class i	26
s proteins of	26
weeks of age	26
with the mhv	26
hingley et al	26
institutes of health	26
replication of mouse	26
acute and chronic	26
cd c cd	26
of mhv spike	26
is important for	26
of c bl	26
leader rna and	26
have demonstrated that	26
dependent enhancement of	26
wang et al	26
translation of the	26
cells were fixed	26
spaan et al	26
known to be	26
fetal calf serum	26
in the er	26
rna was extracted	26
east respiratory syndrome	26
has been suggested	26
the finding that	26
of viral hepatitis	26
have been detected	26
well as in	26
but not the	26
those of the	26
pfu of mhv	26
only in the	26
route of inoculation	26
h hej mice	26
of mutations in	26
jhm strain of	25
min at room	25
be associated with	25
compared to mock	25
evidence for the	25
at h after	25
there was a	25
after h of	25
genetic analysis of	25
restricted to the	25
s cs recombinants	25
were incubated at	25
position of the	25
insight into the	25
processed from the	25
to infection with	25
the white matter	25
virus type infection	25
equine arteritis virus	25
of the family	25
is due to	25
that the mhv	25
of infection of	25
transported to the	25
may have been	25
infection with a	25
of s protein	25
is similar to	25
of a mouse	25
not due to	25
national institutes of	25
were used as	25
of an rna	25
minute virus of	25
of laboratory rodents	25
inbred strains of	25
the most common	25
the gene encoding	25
the current study	25
insights into the	25
murine leukemia virus	25
were purchased from	25
the frequency of	25
and orf b	25
during the acute	25
induced by a	25
at this time	25
amino acid sequences	25
is a member	25
is critical for	25
recombinant vaccinia virus	25
das sarma et	25
in some cases	25
required for viral	25
locker et al	25
been isolated from	25
it can be	25
are consistent with	25
virus and the	25
seems to be	25
one of these	25
the small intestine	25
to the virus	25
was measured by	25
of the liver	25
at the indicated	25
is present in	25
nm in diameter	25
were detected in	25
at least one	25
following intranasal inoculation	25
in the regulation	25
untranslated region of	25
rna was isolated	24
of virus in	24
a and orf	24
mediated by the	24
gene expression in	24
some strains of	24
as a receptor	24
occurs in the	24
sturman and holmes	24
nucleocapsid protein of	24
it is likely	24
and subjected to	24
murine encephalomyelitis virus	24
in terms of	24
gosert et al	24
were used for	24
infected mice were	24
defective interfering rnas	24
the respiratory tract	24
murine coronavirus gene	24
of mhv is	24
crystal structure of	24
was detected by	24
with regard to	24
glycoprotein gene of	24
the onset of	24
the association of	24
c cd b	24
these results indicate	24
was isolated from	24
epithelial cells of	24
after infection and	24
in vitro translation	24
expression of fgl	24
we observed that	24
experimental autoimmune encephalomyelitis	24
correlated with the	24
on the cell	24
nervous system disease	24
and processing of	24
produced by the	24
is difficult to	24
by murine hepatitis	24
human coronavirus oc	24
barthold et al	24
different strains of	24
located at the	24
of virus evolution	24
infected cells was	24
to be an	24
shown in table	24
the jhm strain	24
has been described	24
liver and spleen	24
gombold et al	24
induced by the	24
in a mouse	24
in all cases	24
was performed by	24
to the cns	24
were found in	24
in spinal cord	24
component of the	24
evidence for a	24
the percentage of	24
it is the	24
demonstrate that the	24
pneumonia virus of	24
lesions in the	24
after experimental infection	24
nucleocapsid protein and	24
of the other	24
ivanov et al	24
antibodies to the	23
the presence or	23
reported to be	23
disease in mice	23
of the receptor	23
to assess the	23
at the same	23
been implicated in	23
binds to the	23
are responsible for	23
for viral rna	23
of nsp and	23
porcine transmissible gastroenteritis	23
viral rna replication	23
and the cells	23
the s and	23
in patients with	23
primary structure and	23
that of mhv	23
suggest that mhv	23
compared to wt	23
rna in the	23
c h st	23
compared with the	23
at least two	23
has recently been	23
amino acid residues	23
h a replication	23
to be important	23
is likely that	23
been observed in	23
side of the	23
of infection and	23
also been reported	23
after mhv infection	23
the degree of	23
spread of virus	23
the same time	23
infection in vitro	23
bos et al	23
have been observed	23
subgenomic mrna transcription	23
wild type and	23
avian coronavirus infectious	23
the viral nucleocapsid	23
three times with	23
gene of mhv	23
risco et al	23
in coronavirus replication	23
n a icv	23
of viral infection	23
linked to the	23
the processing of	23
the infected cell	23
has been observed	23
amino acids of	23
and identification of	23
with the same	23
and s proteins	23
the center of	23
makino et a	23
to evaluate the	23
sd and sk	23
the significance of	23
large number of	23
the hypervariable region	23
receptor for mouse	23
was obtained from	23
cell lysates were	23
m protein of	23
of the viruses	23
the differences in	23
of the total	23
we have shown	23
are able to	23
is necessary for	23
titers in the	23
hepatitis virus rna	23
have been used	23
s a a	23
bonilla et al	23
be important for	23
to murine hepatitis	23
of these two	23
that there is	23
evolution of the	23
led to the	23
of amino acids	23
cases at d	23
stranded rna viruses	23
the s proteins	23
zhang et al	23
from the central	23
after intranasal inoculation	23
genomic rna and	22
the innate immune	22
been used to	22
in ml of	22
de groot et	22
serves as a	22
to note that	22
collins et al	22
known about the	22
in the trans	22
and function of	22
low levels of	22
data indicate that	22
parker et al	22
and evolution of	22
it appears that	22
tumor necrosis factor	22
of mhv s	22
mice treated with	22
by mhv infection	22
may be due	22
belongs to the	22
model for the	22
with poly i	22
of gene expression	22
at the cell	22
results showed that	22
lu et al	22
of ibv and	22
in both the	22
in this case	22
in mice and	22
sequences in the	22
in the virus	22
model of multiple	22
expressed in the	22
indicated that the	22
from the same	22
sequences of the	22
is important to	22
for hr at	22
is known about	22
together with the	22
i expression in	22
the specificity of	22
of adult mice	22
with the s	22
and stained with	22
to be more	22
days post inoculation	22
our understanding of	22
viral infection of	22
in vitro transcription	22
be responsible for	22
mice at day	22
were inoculated with	22
protein of the	22
the genomes of	22
of the a	22
the growth of	22
were maintained in	22
the pca response	22
a novel coronavirus	22
smith et al	22
in the murine	22
were added to	22
cd c cells	22
infected with wt	22
provided by dr	22
e l and	22
consistent with a	22
been identified in	22
that in the	22
with the m	22
or absence of	22
none of the	22
of the putative	22
very similar to	22
is capable of	22
r n a	22
the size of	22
of the small	22
in the lung	22
at h post	21
and e proteins	21
cervical lymph nodes	21
a major role	21
antibody to pca	21
for the development	21
is one of	21
not appear to	21
mice inoculated at	21
terminal half of	21
the laboratory mouse	21
the virus can	21
groot et al	21
goebel et al	21
stage of infection	21
present within the	21
of the carcinoembryonic	21
the subgenomic mrnas	21
by the addition	21
it was shown	21
talbot et al	21
of the ibv	21
infection of adult	21
in virus replication	21
to this end	21
ccl and ccl	21
to identify the	21
a dc cells	21
viral and mycoplasmal	21
of the sequence	21
the hypothesis that	21
spread to the	21
the gastrointestinal tract	21
bouvet et al	21
used for the	21
in the serum	21
models of demyelinating	21
but does not	21
intracerebral inoculation of	21
is able to	21
virus is a	21
li et al	21
proteins in the	21
been demonstrated in	21
the family coronaviridae	21
infection can be	21
nsp is a	21
cells transfected with	21
infection with mouse	21
lehmann et al	21
infectious virus was	21
from balb c	21
of other coronaviruses	21
results in the	21
denison et al	21
response to viral	21
mutant of mhv	21
innate and adaptive	21
the analysis of	21
belonging to the	21
m protein is	21
also can be	21
dose of virus	21
of di rna	21
hepatitis virus and	21
at wk of	21
components of the	21
in mice with	21
the virus in	21
with the n	21
there are no	21
relative to the	21
of these mutants	21
livingston and riley	21
viral rna in	21
van der most	21
glycoprotein of murine	21
laboratory mice and	21
results demonstrate that	21
binding of the	21
used in the	21
in mice is	21
sequence of mouse	21
can result in	21
and the virus	21
demyelination produced by	21
the location of	21
of m protein	21
a and a	21
a in the	21
coronavirus rna replication	21
infections of laboratory	21
rna and the	21
from the national	21
a set of	21
been suggested that	21
ferreira and manaker	21
for the mhv	21
change in the	21
was found in	21
a critical role	21
up to days	21
t cell response	21
than that of	21
mice with mhv	21
tooze et al	21
the largest rna	21
show that the	21
presence or absence	21
porcine respiratory coronavirus	21
viral genomic rna	21
replication in cell	21
we examined the	21
and the other	20
use of the	20
and c h	20
the optic nerve	20
compton et al	20
persistent infection with	20
were harvested and	20
of laboratory animals	20
hnrnp a dc	20
results show that	20
the wild type	20
total rna was	20
the rough endoplasmic	20
on the virus	20
that mhv infection	20
ibv and mhv	20
at an m	20
rough endoplasmic reticulum	20
the gene polyprotein	20
coronavirus spike proteins	20
were incubated for	20
that do not	20
of antibody to	20
terminal amino acids	20
type culture collection	20
of this virus	20
on days and	20
and can be	20
we show that	20
in this paper	20
an rna virus	20
cells and macrophages	20
innate immune responses	20
with murine coronavirus	20
in the infection	20
during acute infection	20
the region of	20
in more detail	20
and route of	20
of l cells	20
were derived from	20
with pbs and	20
of demyelinating disease	20
coronavirus avian infectious	20
from the cns	20
the coronavirus infectious	20
context of the	20
has not yet	20
of at least	20
to replicate in	20
gene expression by	20
ibv h bi	20
in this regard	20
been demonstrated to	20
in the control	20
interfering rna replication	20
has been identified	20
leibowitz et al	20
mechanism by which	20
the coronavirus avian	20
stages of the	20
can lead to	20
the difference in	20
regulation of bnip	20
for mhv replication	20
of dn t	20
days of age	20
disruption of the	20
hematoxylin and eosin	20
the origin of	20
for min in	20
an efficient ribosomal	20
formation of a	20
susceptibility to infection	20
the primary structure	20
has been detected	20
not affect the	20
but it is	20
has been used	20
phillips et al	20
destruction of myelin	20
cells were treated	20
of this study	20
are capable of	20
incubated for min	20
were performed in	20
induced by mhv	20
the emergence of	20
nucleotide sequence of	20
intranasal inoculation of	20
in orf b	20
plays an important	20
may play a	20
the coronavirus genome	20
in the development	20
and replication of	20
the levels of	20
binding domain of	20
into virus particles	20
of a viral	20
nested set of	20
all of these	20
the in vivo	20
balb cj mice	20
infectious virus in	20
of demyelination in	20
induced by mouse	20
of mhv in	20
c mice were	20
cloning of the	20
as seen in	20
the livers of	20
bnip gene expression	20
synthesis of the	20
bgp b ntd	20
seem to be	20
site of budding	20
is a common	20
the structure and	20
in the genome	20
for the synthesis	20
analysis of a	20
hepatitis virus jhm	20
a receptor for	20
hirano et al	20
protein is not	20
also been shown	20
only a few	20
fragmentation of the	20
the cns and	19
course of the	19
can be found	19
rna synthesis is	19
in the lungs	19
s and he	19
replication in vitro	19
in the two	19
the ratio of	19
domain of nsp	19
carcinoembryonic antigen family	19
like proteinase of	19
respiratory syncytial virus	19
at least three	19
coronavirus infection in	19
extensive destruction of	19
a recent study	19
cord white matter	19
the viral replication	19
innate immune response	19
of a virus	19
williams et al	19
the cleavage signal	19
coronavirus replication complex	19
with pfu of	19
serve as a	19
within the brain	19
spinal cord white	19
as a consequence	19
the rna was	19
bhardwaj et al	19
the alb ts	19
was performed as	19
at hr postinfection	19
spike protein is	19
m and n	19
l m t	19
mhv has been	19
encoded by the	19
the method of	19
di rna replication	19
supported by a	19
the incorporation of	19
these two viruses	19
american type culture	19
a region of	19
mhv infection is	19
positive cells in	19
the n proteins	19
assembly of the	19
resulting in the	19
of rl mice	19
analysis of rna	19
it is interesting	19
which has been	19
dalcq et al	19
when compared to	19
be important in	19
l and e	19
a major determinant	19
should be noted	19
essential for viral	19
s a and	19
were infected at	19
of mhc class	19
differences between the	19
nicklas et al	19
experiments were performed	19
proteins involved in	19
are considered to	19
may be important	19
replication and spread	19
for the presence	19
we investigated the	19
mouse cell line	19
m t m	19
an in vitro	19
is also possible	19
during mhv infection	19
derived from a	19
pathogenesis of demyelination	19
as shown by	19
matter of the	19
murine coronavirus in	19
nervous system of	19
virus replication is	19
yokomori et al	19
following infection with	19
the untranslated region	19
the brain stem	19
structure and function	19
cell line dbt	19
domain in the	19
mouse thymic virus	19
induced cell fusion	19
accumulate in the	19
difference between the	19
by the virus	19
viral and cellular	19
is related to	19
implications for the	19
were then washed	19
mhv infection and	19
and pathogenesis of	19
the potential to	19
viral rna was	19
effect of the	19
to the viral	19
directed against the	19
which can be	19
a range of	19
differ in their	19
the susceptibility of	19
godet et al	19
in biomedical research	19
was not detected	19
been found to	19
involvement of the	19
within the s	19
except for the	19
occur in the	19
of the wt	19
effects on the	19
due to a	19
are thought to	19
studies of the	19
multiple sclerosis patients	19
green fluorescent protein	19
two of the	18
of the jhm	18
are unable to	18
in wild mice	18
mice that are	18
there is evidence	18
and mycoplasmal infections	18
sethna et al	18
regulation of the	18
the mhv spike	18
are similar to	18
pp a and	18
bhk mceacam a	18
oostra et al	18
infected mice and	18
agreement with the	18
association with the	18
determine whether the	18
in susceptible mice	18
mice can be	18
in a single	18
transcription and translation	18
it does not	18
under the control	18
of mhv strains	18
role in viral	18
the intestinal tract	18
induced demyelinating disease	18
strains of mouse	18
mice from a	18
of the cell	18
this study was	18
kuo et al	18
of these cells	18
amino acid substitution	18
in the c	18
the relationship between	18
major determinant of	18
that hnrnp a	18
semliki forest virus	18
recombinant mouse hepatitis	18
which may be	18
it remains to	18
of the genus	18
was confirmed by	18
intranasal inoculation with	18
and la ts	18
spinal cord and	18
by electrophoresis on	18
was determined using	18
third of the	18
of cats with	18
biochemical characterization of	18
viruses such as	18
especially in the	18
the transcription of	18
and n proteins	18
effects of the	18
virus titers were	18
of clinical disease	18
polymerase activity in	18
of ly e	18
as in the	18
sturman et al	18
cells in a	18
note that the	18
resistance to mhv	18
the functions of	18
the first days	18
pathogenesis of mouse	18
surface of the	18
infection in a	18
l a and	18
structural and functional	18
antigen was detected	18
are likely to	18
to have a	18
stained with hematoxylin	18
the murine hepatitis	18
of mhv h	18
required for efficient	18
and does not	18
with extensive destruction	18
effect on the	18
a total of	18
that the s	18
cells into the	18
to generate a	18
were cultured in	18
determined by the	18
be used for	18
with hematoxylin and	18
not been reported	18
the capacity to	18
e l glycoprotein	18
class i molecules	18
of the fusion	18
chronic demyelinating disease	18
rna replication of	18
of the spinal	18
attributed to the	18
function in the	18
is the first	18
and s fig	18
response to infection	18
the rate of	18
vitro models of	18
mice were infected	18
a consequence of	18
the infection of	18
genes that were	18
domains of the	18
a mutation in	18
mechanisms by which	18
this is the	18
in mouse colonies	18
was present in	18
at the permissive	18
isolated from a	18
strains have been	18
the mhv infection	18
axonal transport of	18
from infected cells	18
xu et al	18
phase of the	18
terminal part of	18
and analyzed by	18
in the rna	18
to be determined	18
clinical signs of	18
were isolated from	18
extended host range	18
the treatment of	18
i ifn response	18
cleavage of p	18
at the site	18
by use of	18
cells in vitro	18
in these cells	18
remain to be	18
that it is	18
to confirm the	18
viruses in the	18
jhm and mhv	18
account for the	18
strains such as	18
inhibition of the	18
is the primary	18
m h v	18
rather than the	18
by targeted rna	18
glial cell cultures	18
a murine virus	18
bredenbeek et al	18
of the p	18
have not yet	18
axonal loss and	17
subunit of the	17
was performed with	17
higher levels of	17
were transfected with	17
critical role in	17
the process of	17
titers were determined	17
not been identified	17
not in the	17
not observed in	17
intracellular transport of	17
correlates with the	17
for the study	17
stability of the	17
structural polypeptides of	17
the translation of	17
in infected mice	17
previous studies have	17
of the t	17
of which is	17
taguchi et al	17
result in a	17
synthesis of a	17
on biomedical research	17
transcription of the	17
primary structure of	17
infected cells in	17
encephalomyelitis with extensive	17
is sufficient to	17
and of the	17
clinical signs and	17
deletions in the	17
in vitro models	17
mhv strain a	17
by day p	17
in the early	17
in animal models	17
taxonomy of viruses	17
was shown that	17
was reported to	17
of the mrna	17
peng et al	17
of the catalytic	17
pathogenesis of coronaviruses	17
seybert et al	17
reduction in the	17
coronavirus spike glycoprotein	17
were present in	17
the packaging signal	17
its role in	17
n protein in	17
protein has been	17
proteins of mhv	17
white matter of	17
for each virus	17
production of ifn	17
of wild type	17
for h with	17
structure in the	17
were incubated in	17
membrane topology of	17
resistance to mouse	17
most et al	17
the acute stage	17
the impact of	17
described in the	17
and lymph nodes	17
been described for	17
interactions of the	17
sites on the	17
be related to	17
barthold and smith	17
induced by coronavirus	17
association of the	17
proposed to be	17
virus nucleocapsid protein	17
within the amino	17
signal in the	17
the natural host	17
replicate in the	17
were removed and	17
to sites of	17
was also observed	17
embryonic stem cells	17
of coronavirus transcription	17
the highly conserved	17
mhv and ibv	17
domains in the	17
translation of a	17
characterization of an	17
of virus and	17
virus has been	17
experimentally infected with	17
chang et al	17
were similar to	17
for the generation	17
whether or not	17
the form of	17
diarrhea of infant	17
inoculation with mhv	17
to the brain	17
t rna polymerase	17
are present in	17
inoculated with mhv	17
in spite of	17
endothelial cells and	17
schickli et al	17
are not essential	17
in orf a	17
cns of mhv	17
of the h	17
fusion of the	17
fatal central nervous	17
in accordance with	17
reverse genetics system	17
pcr products were	17
this type of	17
the active site	17
of bnip gene	17
of the molecule	17
genome of the	17
incubated at the	17
we performed a	17
by using the	17
to the spike	17
both of these	17
fischer et al	17
of the predicted	17
not detected in	17
of the proteins	17
cells were transfected	17
protein from the	17
virions in the	17
heterogeneous nuclear ribonucleoprotein	17
be noted that	17
and did not	17
the morphology of	17
fulminant viral hepatitis	17
encoding the putative	17
athymic nude mice	17
west nile virus	17
and assayed for	17
washed twice with	17
introduced into the	17
susceptible to mhv	17
for murine coronavirus	17
morphology of the	17
jacoby and lindsey	17
other rna viruses	17
mutagenesis of the	17
a model of	17
the brain of	17
to analyze the	17
that the nsp	17
yang et al	17
and pp ab	17
virus infection and	17
mutational analysis of	17
structural proteins and	17
sensitive mutant of	17
viral antigens were	17
by direct contact	17
subgenomic mrna synthesis	17
protein that is	17
in the white	17
resistant to mhv	17
rat liver fah	17
importance of the	17
susceptible and resistant	17
are resistant to	17
monocyte procoagulant activity	16
a and c	16
experimental allergic encephalomyelitis	16
c heb fej	16
than those of	16
mice inoculated with	16
disseminated encephalomyelitis with	16
to be required	16
the supernatant was	16
the viral replicase	16
of immune responses	16
were unable to	16
was not observed	16
the complete sequence	16
murine hepatitis viruses	16
fraction of h	16
is expressed in	16
murine coronavirus infection	16
and rna polymerase	16
and found that	16
infections of mice	16
of the animals	16
of the cov	16
the idea that	16
condensed secretory proteins	16
the envelope proteins	16
wu et al	16
substitution of the	16
of a single	16
as demonstrated by	16
viral rna and	16
added to each	16
mutant hnrnp a	16
respiratory tract disease	16
the activity of	16
essential for the	16
syndrome coronavirus nsp	16
of lymphocytic choriomeningitis	16
of the replication	16
believed to be	16
induced expression of	16
hofmann et al	16
for the induction	16
may result in	16
and viral rna	16
they can be	16
levels in the	16
regulatory t cells	16
the viral infection	16
on the viral	16
clearance of mouse	16
infected with murine	16
in a viral	16
in figure a	16
in the evolution	16
between these two	16
in mhv replication	16
and it is	16
acute phase of	16
the m proteins	16
consistent with this	16
of mouse parvovirus	16
structure of a	16
a lack of	16
effects of mhv	16
infection is not	16
oas rnase l	16
the type of	16
mice of the	16
to form the	16
the s h	16
causing disseminated encephalomyelitis	16
nt of the	16
studies suggest that	16
was extracted from	16
subjected to immunoprecipitation	16
and resuspended in	16
proteins and the	16
performed as described	16
bovine serum albumin	16
of neonatal mice	16
and translation of	16
may lead to	16
but also in	16
of rna viruses	16
immune responses to	16
of the type	16
replication of coronaviruses	16
we have demonstrated	16
nsp dc virus	16
a highly conserved	16
i and ii	16
was performed to	16
difference in the	16
spinal cords of	16
protect mice from	16
course of infection	16
are used to	16
have been found	16
like cysteine proteinase	16
nsp mutant viruses	16
different mhv strains	16
interaction of the	16
group f rna	16
cells were maintained	16
mice results in	16
during persistent infection	16
have been developed	16
is dispensable for	16
by centrifugation at	16
rna and dna	16
infection has been	16
hepatitis virus replication	16
effects on biomedical	16
of nsp is	16
the localization of	16
or in the	16
location of the	16
major role in	16
of in vitro	16
resulting in a	16
respect to the	16
the balb c	16
interactions with the	16
was removed and	16
the possibility of	16
data show that	16
the conservation of	16
protein and the	16
infections in mice	16
and cells were	16
identified in the	16
the olfactory bulb	16
endoplasmic reticulum and	16
yount et al	16
during the early	16
virus infection is	16
that did not	16
has been studied	16
incubated with the	16
at c for	16
of the head	16
lymph nodes and	16
from the brain	16
expression of ifn	16
the university of	16
genomic rna is	16
from persistently infected	16
center of the	16
in the immune	16
infected c h	16
by the presence	16
a concentration of	16
may be the	16
bost et al	16
a type i	16
opstelten et al	16
pathogenic murine coronaviruses	16
the cleavage sites	16
simplex virus type	16
the nasal cavity	16
been studied in	16
experimental inoculation of	16
in the course	16
infected mice at	16
may have a	16
on day after	16
basis for the	16
it is clear	16
days after inoculation	16
hypervariable region of	16
c and tnf	16
with severe acute	16
a and pp	16
the group f	16
in wt mice	16
s in the	16
acting rna elements	16
of suckling mice	16
is interesting to	16
has been found	16
subgenomic rna synthesis	16
in these mice	16
have been isolated	16
virus infection of	16
and central nervous	16
inoculated at wk	16
we were able	16
nucleotides in length	16
tlr and tlr	16
into the mhv	16
is linked to	16
antigenically related to	16
depend on the	16
the genome and	16
are found in	16
identical to the	16
that there are	16
mouse in biomedical	15
products were analyzed	15
of pp a	15
the requirement of	15
cytotoxic t lymphocytes	15
demonstrated in the	15
genes involved in	15
all mhv strains	15
contributes to the	15
assembly of a	15
the cleavage of	15
with nsp and	15
in vitro in	15
it is difficult	15
cells and in	15
required for replication	15
incorporation into virions	15
specific for the	15
ea fraction of	15
inoculum was removed	15
intracellular rna species	15
by means of	15
upper respiratory tract	15
we demonstrate that	15
viral infection in	15
of neutralizing epitopes	15
the coronavirus replicase	15
plaque assay on	15
cells treated with	15
it will be	15
t and b	15
from the american	15
kim et al	15
no effect on	15
recovered from the	15
glycosylation of the	15
the sensitivity of	15
mice were sacrificed	15
transcription and replication	15
were isolated and	15
der most et	15
may occur in	15
n protein of	15
been reported that	15
n protein to	15
the stability of	15
at least in	15
a wide variety	15
of dengue virus	15
the permissive temperature	15
in the leader	15
ends of the	15
many of these	15
m protein was	15
majority of the	15
were seen in	15
nuclear ribonucleoprotein a	15
a di rna	15
of mhv have	15
optic nerve and	15
the american type	15
the source of	15
in these studies	15
interacts with the	15
may be more	15
mouse spinal cord	15
denison and perlman	15
site in the	15
consistent with previous	15
genomic and subgenomic	15
of demyelination and	15
be expected to	15
mice with a	15
to the same	15
have been demonstrated	15
we have used	15
to induce demyelination	15
lipman et al	15
of mhv has	15
infected dbt cells	15
adaptive immune responses	15
red blood cells	15
spike protein of	15
the influence of	15
of mouse colonies	15
subunits of the	15
yu et al	15
of a large	15
receptor for mhv	15
is that the	15
of the major	15
terminal region of	15
the national institutes	15
not result in	15
to the s	15
specific t cells	15
regardless of the	15
by electron microscopy	15
murine coronavirus rna	15
analyzed by electrophoresis	15
of the bnip	15
the rna polymerase	15
been proposed to	15
haspel et al	15
of cells with	15
was not affected	15
with ml of	15
leading to the	15
of the arterivirus	15
wild type mhv	15
only a small	15
persistence in the	15
ricagno et al	15
harcourt et al	15
neuman et al	15
days and p	15
interact with the	15
viral hepatitis in	15
gene of murine	15
are essential for	15
of influenza a	15
alterations in the	15
and mouse hepatitis	15
baric et a	15
in the virion	15
was similar to	15
was generated by	15
which is a	15
it was not	15
these viruses are	15
agarose gel electrophoresis	15
cells as well	15
for the role	15
sjl j mice	15
isolation of a	15
plays a role	15
maintained at the	15
in line with	15
infection and the	15
also in the	15
immune response in	15
was performed in	15
western blot analysis	15
a mouse model	15
of these genes	15
the sites of	15
the united states	15
of the mutants	15
were resuspended in	15
keck et al	15
view of the	15
were washed three	15
region of mhv	15
infection is associated	15
rna recombination of	15
l cell monolayers	15
immunodeficiency virus type	15
polymerase gene of	15
during chronic infection	15
on dbt cells	15
nervous system demyelination	15
analysis was performed	15
lin et al	15
allowed us to	15
cloned into the	15
early stage of	15
should not be	15
acids of the	15
takes place at	15
the adoptive transfer	15
and the presence	15
the samples were	15
wide variety of	15
biology and pathogenesis	15
an equal volume	15
from that of	15
contributed to the	15
the protein is	15
in cultured cells	15
like proteinase activity	15
of the large	15
corning et al	15
route of infection	15
most of these	15
the nonpermissive temperature	15
chronic central nervous	15
and demyelination in	15
is clear that	15
the action of	15
a portion of	15
important role for	15
need to be	15
jhm virus infection	15
minimal essential medium	15
findings suggest that	15
from the mhv	15
equal volume of	15
garwes et al	15
was mixed with	15
with those of	15
on the virion	15
in j a	15
for rna replication	15
as opposed to	15
of demyelination induced	15
t cells from	15
in coronavirus rna	15
humoral immune response	15
cells from the	15
shindler et al	15
with high mortality	15
protein with the	15
mhv have been	15
the life cycle	15
infected by mhv	15
may be involved	15
deletion of the	15
the secretion of	15
different cell types	15
the mouse in	15
protein gene of	15
of inflammatory cells	15
genomic rna of	15
be seen in	15
regions in the	15
but not for	15
examination of the	15
listed in table	15
in mouse cell	15
of the interaction	15
hepatitis virus the	15
in a variety	15
incubated at c	15
does not appear	15
of mhv was	15
group ii coronaviruses	15
rna viruses that	15
both of which	15
analyzed by sds	15
that can be	15
important in the	15
essential role in	15
a persistent infection	15
cells were cultured	15
in this model	15
length infectious cdna	15
induction of pca	15
were grown in	15
between s and	15
orfs a and	15
of the second	15
to the leader	15
be mediated by	14
animal models of	14
early in infection	14
ability to induce	14
is the major	14
of a putative	14
the same as	14
little or no	14
analysis of murine	14
hepatitis in mice	14
murine and human	14
to the end	14
the concentration of	14
the h d	14
the culture medium	14
the age of	14
family of glycoproteins	14
should be considered	14
carboxy terminus of	14
it is a	14
map to the	14
factors such as	14
a infected cells	14
in the intestine	14
of each of	14
may be required	14
of demyelinating diseases	14
astrocytes in the	14
is conserved in	14
dick et al	14
has previously been	14
induction of the	14
and the potential	14
the recombination frequency	14
we compared the	14
sequence in the	14
heb fej mice	14
entry into the	14
relationship between the	14
are expressed as	14
also observed in	14
of the severe	14
carried out by	14
the he gene	14
rats and mice	14
the nsp nsp	14
bl mice were	14
from patients with	14
sequence at the	14
the interactions between	14
mice at days	14
of the different	14
comparative analysis of	14
terminal genome regions	14
and nsp are	14
the position of	14
functions of the	14
immunopathology of mouse	14
the gene expression	14