quadgram

This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

quadgram	frequency
of mouse hepatitis virus	498
q q q q	236
severe acute respiratory syndrome	203
in the absence of	166
in the presence of	161
the central nervous system	153
acute respiratory syndrome coronavirus	137
coronavirus mouse hepatitis virus	130
mouse hepatitis virus strain	121
of the murine coronavirus	116
hepatitis virus strain a	89
mouse hepatitis virus a	81
has been shown to	81
mouse hepatitis virus infection	77
avian infectious bronchitis virus	73
mouse hepatitis virus type	70
to mouse hepatitis virus	70
of murine hepatitis virus	69
on the other hand	67
cells were infected with	66
with mouse hepatitis virus	65
of severe acute respiratory	62
in the central nervous	62
it is possible that	58
of the s protein	57
feline infectious peritonitis virus	55
as well as the	55
coronavirus infectious bronchitis virus	55
the end of the	55
by mouse hepatitis virus	55
murine coronavirus spike protein	54
the coronavirus mouse hepatitis	54
the severe acute respiratory	53
in the case of	53
as shown in fig	52
have been shown to	52
in vitro and in	51
it has been shown	50
the murine coronavirus spike	49
of the n protein	49
of feline infectious peritonitis	48
has been shown that	47
in mice infected with	47
as a result of	47
at an moi of	46
a member of the	45
end of the genome	45
murine hepatitis virus strain	45
an important role in	45
play a role in	45
of the m protein	44
cd c t cells	44
in cells infected with	44
of a murine coronavirus	44
in the spinal cord	42
were infected with mhv	42
in the pathogenesis of	42
of the central nervous	41
mice infected with mhv	41
in the context of	41
in contrast to the	41
the molecular biology of	40
de haan et al	40
in vivo and in	39
in the golgi complex	39
the mouse hepatitis virus	39
was found to be	39
a mouse hepatitis virus	38
vitro and in vivo	37
is not essential for	37
vivo and in vitro	37
in viral rna synthesis	37
the presence of the	37
strain of mouse hepatitis	37
been shown to be	37
a multiplicity of infection	36
at the end of	36
infected with mouse hepatitis	35
mutants of mouse hepatitis	35
cd and cd t	35
in the s gene	35
of the coronavirus mouse	35
similar to that of	35
and cd t cells	35
is consistent with the	34
murine coronavirus mouse hepatitis	34
brain and spinal cord	34
of the coronavirus mhv	33
at a multiplicity of	33
the ability of the	32
the s glycoprotein gene	32
these data suggest that	32
infection of the cns	32
the formation of the	31
for mouse hepatitis virus	31
in the cns of	31
sequence analysis of the	31
for the detection of	30
this work was supported	30
at the time of	30
mouse hepatitis virus is	30
and characterization of a	30
to be involved in	30
of coronavirus mouse hepatitis	30
on the basis of	30
to the plasma membrane	30
of avian infectious bronchitis	30
can be used to	30
must be differentiated from	29
studies have shown that	29
mouse hepatitis virus in	29
the sequence of the	29
of the mouse hepatitis	29
identification and characterization of	28
in mouse hepatitis virus	28
molecular biology of coronaviruses	28
the e glycoprotein of	28
the a strain of	28
these results suggest that	28
in the brains of	28
is not required for	28
in the present study	28
mice infected with a	28
the total number of	28
the role of the	28
the presence of a	27
balb c and c	27
dbt cells were infected	27
of the immune system	27
in addition to the	27
during the course of	27
to the cell surface	27
in the formation of	27
in response to mhv	26
with the exception of	26
of the viral genome	26
of the spike glycoprotein	26
the s gene of	26
play an important role	26
replication of mouse hepatitis	26
of the e glycoprotein	26
was added to the	26
c h hej mice	26
as well as in	26
h at room temperature	26
middle east respiratory syndrome	26
the s protein of	26
for min at room	25
i i i i	25
mouse hepatitis virus from	25
is a member of	25
of the genomic rna	25
of infectious bronchitis virus	25
the murine coronavirus mhv	25
is possible that the	25
of the genome of	25
national institutes of health	25
one of the most	25
hepatitis virus strain jhm	25
in the regulation of	25
das sarma et al	25
were found to be	24
pneumonia virus of mice	24
incubated for h at	24
the development of a	24
work was supported by	24
in balb c mice	24
of the spike protein	24
cd c cd b	24
coronavirus defective interfering rna	24
with a neurotropic coronavirus	24
is thought to be	24
of the s gene	24
the s protein is	24
minute virus of mice	24
of cd t cells	23
these results indicate that	23
orf a and orf	23
of viral rna synthesis	23
receptor for mouse hepatitis	23
of type i ifn	23
of the mhv genome	23
for h at room	23
it is likely that	23
to murine hepatitis virus	23
the expression of fgl	23
of the virus to	23
min at room temperature	23
avian coronavirus infectious bronchitis	23
murine hepatitis virus type	23
cases at d p	23
inbred strains of mice	23
in the cytoplasm of	23
on the surface of	23
a and orf b	22
determined by plaque assay	22
the immune response to	22
may be due to	22
cells infected with mhv	22
mouse hepatitis virus rna	22
by murine hepatitis virus	22
model of multiple sclerosis	22
of murine coronavirus gene	22
the gene encoding the	22
specific cd t cells	22
of a neurotropic coronavirus	21
presence or absence of	21
has been reported to	21
mhv h a replication	21
the presence or absence	21
is likely to be	21
m and e proteins	21
c and c bl	21
de groot et al	21
of the carcinoembryonic antigen	21
infection of mice with	21
for the development of	21
was observed in the	21
to that of the	21
by the addition of	21
the type i ifn	21
it has been suggested	21
the nucleocapsid protein of	21
at wk of age	21
the brain and spinal	21
infection of the central	21
proteolytic cleavage of the	21
central nervous system disease	21
class i expression in	21
it is important to	21
the jhm strain of	21
used in this study	20
balb c mice were	20
the structure of the	20
hepatitis virus type infection	20
for the synthesis of	20
has not yet been	20
coronavirus avian infectious bronchitis	20
plays an important role	20
and c bl mice	20
replication in cell culture	20
in the development of	20
has also been reported	20
the coronavirus infectious bronchitis	20
of the viral envelope	20
mhv infection of the	20
from the central nervous	20
induced by mouse hepatitis	20
of the polymerase gene	20
in the nasal mucosa	19
and incubated for h	19
be used to detect	19
american type culture collection	19
in the current study	19
of mice infected with	19
defective interfering rna replication	19
the context of the	19
washed three times with	19
at the cell surface	19
l m t m	19
of mutations in the	19
e l and e	19
mutations in the s	19
spinal cord white matter	19
the n protein is	19
as a model for	19
has been suggested that	19
can be detected by	19
the coronavirus avian infectious	19
of the golgi apparatus	19
the rough endoplasmic reticulum	19
of the recombinant viruses	18
the expression of the	18
in the presence or	18
of the gene encoding	18
vitro models of demyelinating	18
the mhv n protein	18
under the control of	18
proteolytic processing of the	18
mouse cell line dbt	18
is one of the	18
on the cell surface	18
extensive destruction of myelin	18
infection with mouse hepatitis	18
the m protein of	18
of the structural proteins	18
for the presence of	18
hepatitis virus infection in	18
in the liver and	18
we found that the	18
with extensive destruction of	18
mouse hepatitis virus and	18
was used as a	18
in the brain and	18
it remains to be	18
infected with a neurotropic	18
type i ifn response	18
of dn t cells	18
viral and mycoplasmal infections	18
by targeted rna recombination	18
the carcinoembryonic antigen family	18
it should be noted	18
of the human coronavirus	18
of balb c mice	18
to the golgi complex	17
a murine coronavirus in	17
it has been reported	17
as shown in figure	17
untranslated region of the	17
a critical role in	17
in vitro models of	17
sensitive mutants of mouse	17
of mhv h a	17
glycoprotein of murine coronavirus	17
of the mhv s	17
the course of the	17
terminal amino acids of	17
of mhc class i	17
for viral rna synthesis	17
and in vitro models	17
m and s proteins	17
the mhv s protein	17
porcine transmissible gastroenteritis virus	17
the cns of mhv	17
nucleotide sequence of the	17
pathogenesis of mouse hepatitis	17
with hematoxylin and eosin	17
and the cells were	17
for the generation of	17
resistance to mouse hepatitis	17
in the s glycoprotein	17
identification of a new	17
is known about the	17
it was shown that	17
mice at day p	17
were infected with wt	17
to determine whether the	17
member of the carcinoembryonic	17
diarrhea of infant mice	17
of the e protein	17
epithelial cells of the	17
of the spinal cord	17
viral infection of the	17
of the mhv n	17
may contribute to the	16
in the spike glycoprotein	16
pp a and pp	16
it is not clear	16
the murine hepatitis virus	16
disseminated encephalomyelitis with extensive	16
for the study of	16
the specificity of the	16
end of the leader	16
a major role in	16
infections of laboratory rodents	16
similar to those of	16
respiratory syndrome coronavirus nsp	16
the e l glycoprotein	16
the s h d	16
it is interesting to	16
is associated with the	16
is responsible for the	16
has been detected in	16
clearance of mouse hepatitis	16
by the presence of	16
terminal domain of the	16
with the m protein	16
of the immune response	16
ability of the virus	16
in the evolution of	16
following mhv infection of	16
cd t cells in	16
cells in the cns	16
may play a role	16
be due to the	16
of mouse hepatitis viruses	16
was shown to be	16
with respect to the	16
with severe acute respiratory	16
were observed in the	16
of the sars coronavirus	16
causing disseminated encephalomyelitis with	16
cells were transfected with	16
have not yet been	16
monoclonal antibodies to the	16
in the course of	16
central nervous system of	16
recombinant mouse hepatitis virus	16
the cells were washed	16
of transmissible gastroenteritis virus	16
the structural proteins of	16
in the white matter	16
cells were incubated with	16
effects on biomedical research	16
a wide variety of	15
of lymphocytic choriomeningitis virus	15
coronavirus spike protein is	15
different strains of mhv	15
gene of murine coronavirus	15
viral antigen was detected	15
were washed three times	15
chronic central nervous system	15
we were able to	15
strains of mouse hepatitis	15
gene encoding the putative	15
of nsp and nsp	15
encephalomyelitis with extensive destruction	15
fatal central nervous system	15
herpes simplex virus type	15
incubated for min at	15
a role in the	15
at the same time	15
in the spike protein	15
the untranslated region of	15
are considered to be	15
sequence of mouse hepatitis	15
are shown in figure	15
be found in the	15
important role in the	15
rna replication and transcription	15
heterogeneous nuclear ribonucleoprotein a	15
a and pp ab	15
were washed with pbs	15
the interaction between the	15
of the coronavirus avian	15
of m and s	15
cells as well as	15
van der most et	15
the national institutes of	15
of demyelination induced by	15
mouse in biomedical research	15
at days post infection	15
during the first days	15
the mouse in biomedical	15
as compared to the	15
the function of the	15
pathogenesis of demyelination induced	15
of infectious virus in	15
the human coronavirus e	15
der most et al	15
it is difficult to	15
that the n protein	15
the genome of the	15
in agreement with the	15
stained with hematoxylin and	15
region of the coronavirus	15
are involved in the	15
also been shown to	15
it is clear that	15
has also been shown	15
the importance of the	15
infection is associated with	15
at the site of	15
in a variety of	15
the n protein was	15
at days post inoculation	15
the american type culture	15
ea fraction of h	15
for the role of	15
the center of the	15
an equal volume of	15
a major determinant of	15
have been detected in	15
central nervous system demyelination	15
by a mouse hepatitis	14
virus from the central	14
c bl mice were	14
and mhv h a	14
processed from the replicase	14
mouse hepatitis virus the	14
for the induction of	14
biology and pathogenesis of	14
has been demonstrated in	14
it is not known	14
end of the viral	14
not essential for viral	14
we have shown that	14
the s proteins of	14
response to mhv infection	14
the early secretory pathway	14
s h d recombinants	14
infection in the cns	14
mycoplasmal infections of laboratory	14
to be required for	14
a strain of mouse	14
a large number of	14
of c bl mice	14
are consistent with the	14
cells were incubated at	14
and mycoplasmal infections of	14
response to viral infection	14
amino acids of the	14
in the immune response	14
fig and s fig	14
did not affect the	14
the ea fraction of	14
rna was extracted from	14
kindly provided by dr	14
in c bl mice	14
viral replication in the	14
the synthesis of the	14
been shown that the	14
inoculated at wk of	14
be differentiated from other	14
there is no evidence	14
human immunodeficiency virus type	14
of the severe acute	14
cleavage of the e	14
the acute phase of	14
should be noted that	14
primary structure of the	14
experimental infection of adult	14
from the replicase gene	14
after infection with mhv	14
in the infected cell	14
of viral antigen in	14
the n protein of	14
cells were treated with	14
can be found in	14
s fig and s	14
from the american type	14
the n protein and	14
shown in figure a	14
the binding of the	14
open reading frame a	14
infected with murine coronavirus	14
rna polymerase activity in	14
carcinoembryonic antigen family of	14
the nature of the	14
at room temperature with	14
is a major determinant	14
orfs a and b	14
fragmentation of the ga	14
th clone p b	14
has been reported that	14
in materials and methods	14
does not appear to	14
mice to mouse hepatitis	14
mice inoculated at wk	14
the s cs recombinants	14
the site of budding	14
of central nervous system	13
in the endoplasmic reticulum	13
of a novel coronavirus	13
has been reported in	13
the primary structure and	13
immunopathology of mouse hepatitis	13
between s and s	13
presence of actinomycin d	13
in the form of	13
and expression of the	13
the rest of the	13
susceptible strains of mice	13
at the nonpermissive temperature	13
length infectious cdna of	13
can be detected in	13
of the golgi complex	13
a mutation in the	13
of infected cells was	13
titers of infectious virus	13
described in materials and	13
the absence of the	13
the acute stage of	13
of a mouse hepatitis	13
little is known about	13
the majority of the	13
to determine if the	13
sections were stained with	13
the leader rna and	13
virus takes place at	13
of mouse hepatitis coronavirus	13
of mhv infection in	13
the cytoplasm of infected	13
the murine coronavirus mouse	13
essential for viral replication	13
data suggest that the	13
c heb fej mice	13
on the presence of	13
was detected in the	13
induced by a mouse	13
mice infected with mouse	13
the infectious bronchitis virus	13
of the viral rna	13
cells were washed with	13
like proteinase of the	13
in murine hepatitis virus	13
infectious virus in the	13
the presence of actinomycin	13
mice infected with the	13
cytoplasm of infected cells	13
positive cells in the	13
e glycoprotein of murine	13
was not due to	13
plays a role in	13
dependent rna polymerase activity	13
and route of inoculation	13
terminal half of the	13
with pfu of mhv	13
east respiratory syndrome coronavirus	13
hepatitis virus takes place	13
of cd c t	13
the presence of an	13
the results showed that	13
rna replication of mouse	13
in mouse cell line	13
in the united states	13
antigen family of glycoproteins	13
interesting to note that	13
at the level of	13
as described in materials	13
with fetal bovine serum	13
a strain of mhv	13
alb ts and la	13
both cd and cd	13
enterotropic mouse hepatitis virus	13
these data indicate that	13
the alb ts icv	13
multiplicity of infection of	13
spike protein is a	13
at the permissive temperature	13
be detected in the	13
the replicase gene polyprotein	13
mouse hepatitis virus takes	13
rna was isolated from	13
ts and la ts	13
is interesting to note	13
has not been reported	13
demyelination induced by a	13
of transmissible gastroenteritis coronavirus	13
mice persistently infected with	13
group f rna mutants	12
is associated with a	12
central nervous system requires	12
the course of infection	12
we have previously shown	12
the formation of a	12
and pathogenesis of coronaviruses	12
was not detected in	12
binding domain of the	12
of the orf a	12
were determined by plaque	12
at this time point	12
and central nervous system	12
a high incidence of	12
in the serum of	12
mice experimentally infected with	12
c h st mice	12
functional analysis of the	12
of the virus in	12
under materials and methods	12
during the acute stage	12
the pathogenesis of viral	12
our understanding of the	12
the innate immune response	12
to the development of	12
and influenza c virus	12
mutations in the spike	12
transported to the plasma	12
of the e l	12
pathogenesis of feline infectious	12
remains to be determined	12
experimental demyelination produced by	12
by plaque assay on	12
polymerase is expressed by	12
for the production of	12
the m protein is	12
of hepatitis c virus	12
l a t a	12
rna of mouse hepatitis	12
been reported to be	12
mice were purchased from	12
the biology and pathogenesis	12
to the pathogenesis of	12
b c f mice	12
sensitive mutant of mhv	12
cells into the cns	12
cd t cells were	12
an essential role in	12
the avian coronavirus infectious	12
of the coronavirus ibv	12
at room temperature for	12
murine coronavirus spike glycoprotein	12
s j l j	12
to the formation of	12
an important role for	12
the spike glycoprotein ectodomain	12
for the first time	12
a recombinant vaccinia virus	12
amino acid substitutions in	12
jhm strain of mhv	12
results suggest that the	12
it has been proposed	12
is required for efficient	12
of cd c cells	12
the international committee on	12
cells were harvested and	12
systematic assembly of a	12
the mechanisms by which	12
could be due to	12
may be involved in	12
a final concentration of	12
gene of mouse hepatitis	12
mice were inoculated intranasally	12
virus replication in the	12
amino acid sequence analysis	12
of type i ifns	12
in order to determine	12
polymerase gene of the	12
of the type i	12
as well as a	12
mice from a lethal	12
in the induction of	12
virus is a member	12
as described in the	12
it has also been	12
in the murine coronavirus	12
is known to be	12
titers were determined by	12
the position of the	12
as a receptor for	12
is present in the	12
which is consistent with	12
of the coronavirus genome	12
the causative agent of	12
a neurotropic murine coronavirus	12
involved in viral rna	12
of murine coronavirus jhm	12
products were analyzed by	12
a conformational change in	12
of m s complexes	12
takes place at double	12
of the coronavirus infectious	12
is not yet clear	12
the presence of viral	12
of each of the	12
our results suggest that	12
athymic foxn nu mice	12
the study of the	12
icv at an moi	12
the adoptive transfer of	12
the m and e	12
in response to viral	12
in the n protein	12
considered to be a	12
innate and adaptive immune	12
of the leader rna	12
enhanced green fluorescent protein	12
antibodies to murine hepatitis	12
demyelination produced by the	11
are similar to those	11
confers susceptibility to mhv	11
of bnip gene expression	11
coronavirus gene encoding the	11
an increase in the	11
was determined by plaque	11
immediately downstream of the	11
functional domains in the	11
the ventral and lateral	11
within the central nervous	11
coronavirus by substitution of	11
putative functional domains in	11
a and mhv h	11
association of m and	11
assembly of a full	11
has been proposed that	11
rna virus of the	11
are not essential for	11
the absence of cd	11
by agarose gel electrophoresis	11
in inbred strains of	11
in the untranslated region	11
at the indicated times	11
of mhv have been	11
these findings suggest that	11
the amino acid sequence	11
infectious cdna of mouse	11
substitution of the spike	11
of herpes simplex virus	11
it is also possible	11
set of infected cells	11
lines confers susceptibility to	11
the second open reading	11
of monocyte procoagulant activity	11
have shown that the	11
of bovine coronavirus is	11
from mice infected with	11
genome of the coronavirus	11
host cell species barrier	11
the cns of mice	11
retargeting of coronavirus by	11
amino acid sequences of	11
c bl j mice	11
infection in immunocompetent mice	11
have been reported to	11
murine coronavirus gene encoding	11
from the end of	11
of dbt cells were	11
described under materials and	11
obtained from the american	11
produced by the a	11
analyzed by electrophoresis on	11
mouse hepatitis virus jhm	11
the early phase of	11
dependent enhancement of feline	11
total number of axons	11
we were unable to	11
the putative proteases and	11
putative proteases and rna	11
were inoculated intranasally with	11
of coronavirus by substitution	11
is shown in fig	11
models of demyelinating diseases	11
the pol zn site	11
has been isolated from	11
cell lines confers susceptibility	11
to note that the	11
enhancement of feline infectious	11
there is evidence that	11
of neutralizing epitopes and	11
are susceptible to infection	11
cdna of mouse hepatitis	11
is located at the	11
that the expression of	11
of murine coronavirus spike	11
dose and route of	11
to be responsible for	11
and balb c mice	11
the spike glycoprotein of	11
in tissue culture cells	11
from central nervous system	11
of the endoplasmic reticulum	11
terminal part of the	11
the th clone p	11
with the development of	11
virus mouse hepatitis virus	11
the largest rna virus	11
a similar pattern of	11
mice infected intranasally with	11
in contemporary mouse colonies	11
for the treatment of	11
hepatitis virus is a	11
in the di rna	11
of viral replication in	11
spinal cord grey matter	11
the cells were incubated	11
by the a strain	11
to the end of	11
the location of the	11
added to the cells	11
hepatitis virus in the	11
the polymerase gene of	11
and the presence of	11
the ibv spike gene	11
is also possible that	11
the absence of rnase	11
subjected to immunoprecipitation with	11
murine hepatitis virus nsp	11
during mouse hepatitis virus	11
susceptible and resistant mice	11
of the mhv receptor	11
the host cell species	11
and mouse hepatitis virus	11
in the livers of	11
the outcome of infection	11
the number of infected	11
second open reading frame	11
of the genome and	11
have been identified in	11
encoding the putative proteases	11
one set of infected	11
regulation of bnip gene	11
from the gene polyprotein	11
the mechanism by which	11
of the a strain	11
localization of neutralizing epitopes	11
by substitution of the	11
and the number of	11
of the sars virus	11
ventral and lateral columns	11
cd t cells are	11
of putative functional domains	11
with the n protein	11
crossing the host cell	11
are shown in fig	11
but not in the	11
the sars virus genome	11
proteinase of the murine	11
proteases and rna polymerase	11
at later time points	11
absence of rnase l	11
at the restrictive temperature	11
are members of the	11
viral rna synthesis and	11
viral rna synthesis in	11
and function of the	11
axonal loss and demyelination	11
may be required for	11
in the optic nerve	11
has the potential to	11
cd t cell response	11
mutational analysis of the	11
has been used to	11
of the cleavage site	11
cells was shifted to	11
in the mhv s	11
cells were maintained in	11
in their ability to	11
of the virus and	11
s a and s	11
infection of adult mice	11
mouse hepatitis virus nonstructural	11
than that of the	10
coronavirus nonstructural protein nsp	10
genetic control and the	10
like particles by co	10
is expressed by an	10
infectious bronchitis virus the	10
the group f rna	10
to those of the	10
as well as other	10
cells as previously described	10
have been isolated from	10
that some of the	10
similar results were obtained	10
these results demonstrate that	10
open reading frame of	10
some strains of mhv	10
a domain required for	10
total rna was isolated	10
despite the fact that	10
in the rbd of	10
nsp and nsp are	10
the murine coronavirus jhm	10
is supported by the	10
a l b c	10
to further investigate the	10
epizootic diarrhea of infant	10
demyelination produced by a	10
by comparative amino acid	10
infected cells and in	10
isolation and characterization of	10
endothelial cells and astrocytes	10
two sets of dbt	10
cells of the nasal	10
the n proteins of	10
gene of coronavirus mouse	10
spike glycoprotein gene of	10
major determinant of neurovirulence	10
the cleavage of p	10
virus titers in the	10
from balb c mice	10
of rnase l in	10
to interact with the	10
expression of the second	10
the virus and the	10
induction of type i	10
gene of the coronavirus	10
an efficient ribosomal frameshifting	10
coronaviruses of other species	10
shifting signal in the	10
as described under materials	10
cells infected with the	10
and the role of	10
has not been determined	10
cells were fixed and	10
polyprotein by comparative amino	10
terminus of pol a	10
cell line dbt culture	10
the lack of a	10
and processing of the	10
spread of a neurotropic	10
coronavirus gene a polyprotein	10
results showed that the	10
plaque formation of mouse	10
is based on the	10
analysis of murine hepatitis	10
frame of the polymerase	10
protein is a major	10
nervous system demyelination in	10
at a concentration of	10
glycoprotein responsible for attachment	10
viral glycoprotein responsible for	10
respiratory syndrome coronavirus nonstructural	10
mouse hepatitis virus produce	10
absence of helper virus	10
in a j mice	10
high incidence of demyelination	10
produce a high incidence	10
monoclonal antibodies to murine	10
of a domain required	10
epitopes and the receptor	10
s h d r	10
virus produce a high	10
the exception of the	10
system demyelination in mice	10
a standard plaque assay	10
end of the genomic	10
the major site of	10
is considered to be	10
the viral genomic rna	10
resistant a j mice	10
to the spike glycoprotein	10
fold molar excess of	10
define the viral glycoprotein	10
of the infectious bronchitis	10
against mouse hepatitis virus	10
responsible for attachment and	10
syndrome coronavirus nsp protein	10
persistent mouse hepatitis virus	10
plays a critical role	10
the absence of helper	10
procoagulant activity by murine	10
glycoprotein gene of coronavirus	10
von brunn et al	10
central nervous system infection	10
cleavage of murine coronavirus	10
susceptible to infection by	10
formation of mouse hepatitis	10
the effect of the	10
expressed by an efficient	10
has been demonstrated for	10
of the second open	10
in nsp and nsp	10
mice were infected with	10
identification of a domain	10
at c for min	10
by the use of	10
models of demyelinating disease	10
viral model of multiple	10
has been associated with	10
be related to the	10
the viral glycoprotein responsible	10
an efficient ribosomal frame	10
hepatitis virus strain infection	10
t cells into the	10
hepatitis virus a in	10
a and s a	10
virus in tissue culture	10
s and he proteins	10
jhm strain of mouse	10
of antibody to pca	10
mechanism of synthesis of	10
was added to each	10
incubated at the non	10
monocyte procoagulant activity by	10
within the brains of	10
the cytoplasmic tail of	10
in feline infectious peritonitis	10
the spike glycoprotein gene	10
from transmissible gastroenteritis virus	10
reading frame of the	10
a high degree of	10
performed as described previously	10
respiratory syndrome coronavirus replication	10
for attachment and cell	10
in balb c and	10
replication and expression of	10
protein binds to the	10
hepatitis virus produce a	10
was performed as described	10
the hypervariable region of	10
expression in human and	10
of the leader sequence	10
in mhv h a	10
the vast majority of	10
processing of the n	10
of coronavirus infection in	10
the s and s	10
at late time points	10
localization of mouse hepatitis	10
in the brain of	10
in view of the	10
chimeric spike gene recombinants	10
has been implicated in	10
cells were then washed	10
to a number of	10
detection of antibodies to	10
murine coronavirus gene a	10
associated with severe acute	10
s glycoprotein gene of	10
been proposed to be	10
demyelination in mice after	10
comparative amino acid sequence	10
mouse colonies in the	10
it is known that	10
has been attributed to	10
of the laboratory mouse	10
balb c and sjl	10
for the n protein	10
could not be detected	10
in the small intestine	10
pellet was resuspended in	10
the virus can be	10
of the sequence of	10
completion of the sequence	10
used as a model	10
a key role in	10
the coronavirus m protein	10
it is conceivable that	10
and plaque formation of	10
the mesenteric lymph nodes	10
s gene with the	10
in the generation of	10
the control of the	10
the pathogenesis of mhv	10
the site of virus	10
at the exit from	10
from the national institutes	10
persistently infected with mhv	10
prediction of putative functional	10
and in the mouse	10
in the grey matter	10
in human and hamster	10
independent assembly of coronavirus	10
in mice after jhm	10
the fact that the	10
the evolution of the	10
is believed to be	10
b a l b	10
is similar to the	10
replication and plaque formation	10
the infected cells were	9
in the infected cells	9
the murine coronavirus genome	9
for virus replication in	9
m and n proteins	9
of a human coronavirus	9
is supported by a	9
viral envelope protein genes	9
optic neuritis induced by	9
to bind to rna	9
our results demonstrate that	9
on the growth of	9
are likely to be	9
to a lesser extent	9
acids of the murine	9
were kindly provided by	9
at the cleavage site	9
requirement for an rna	9
amino acid sequence of	9
recombinant viruses derived from	9
characterization of a coronavirus	9
enhanced growth of a	9
by in situ hybridization	9
of virus in the	9
the mechanism of rna	9
h after infection and	9
tropism of mouse hepatitis	9
of e l and	9
to be important for	9
in the respiratory tract	9
and hsp bind to	9
this result suggests that	9
were similar to those	9
of the s glycoprotein	9
efficient ribosomal frameshifting mechanism	9
highly conserved polymerase is	9
the crystal structure of	9
in the golgi apparatus	9
by an efficient ribosomal	9
infectious bronchitis virus a	9
response to mouse hepatitis	9
results indicate that the	9
stimulate class i expression	9
a novel type of	9
the rbd of s	9
been implicated in the	9
and the potential for	9
has been studied in	9
these data suggested that	9
and functional analysis of	9
has not been identified	9
cloning of the mouse	9
as well as for	9
a viral model of	9
rna synthesis of a	9
of the n molecule	9
and subjected to immunoprecipitation	9
very similar to that	9
antigen was detected in	9
and adaptive immune responses	9
structure and expression of	9
of coronavirus nonstructural protein	9
with nsp and nsp	9
mice mouse hepatitis virus	9
of the mhv infection	9
neurotropic jhmv and weakly	9
this is supported by	9
be involved in the	9
hepatitis b virus infection	9
of viral envelope protein	9
with icwt or nsp	9
beyond the site of	9
have been associated with	9
not appear to be	9
end of the mhv	9
on the mouse strain	9
the genomic rna and	9
to replicate in the	9
the cell periphery and	9
at the indicated time	9
hepatitis virus jhm strain	9
laboratory mice and rats	9
the effects of mhv	9
with the fact that	9
may be important in	9
were obtained from the	9
dbt cells infected with	9
the p and p	9
that the presence of	9
murine coronavirus in the	9
the absence of other	9
of mhv rna synthesis	9
one day prior to	9
it is not yet	9
autoproteolytic cleavage of murine	9
cells transfected with pmh	9
is not yet known	9
in vitro translation of	9
members of the family	9
the assembly of the	9
of viral rna in	9
region of the mhv	9
the nasal mucosa and	9
primary structure and expression	9
reverse genetics system for	9
of a novel type	9
mouse central nervous system	9
the cells were then	9
processing of the coronavirus	9
demyelination and axonal loss	9
the viral replication cycle	9
of wild type and	9
the indicated time points	9
involved in rna synthesis	9
in infected cells the	9
of the pca response	9
international committee on taxonomy	9
with the plasma membrane	9
the cleavage signal of	9
murine hepatitis virus jhm	9
vitro and in the	9
i expression in astrocytes	9
during the acute phase	9
appears to be the	9
and the murine neuron	9
of a variety of	9
of the coronavirus replication	9
respiratory syndrome coronavirus replicase	9
plays an essential role	9
in the processing of	9
in the gastrointestinal tract	9
several members of the	9
to the site of	9
be the result of	9
referred to as the	9
strongly neurotropic jhmv and	9
the virus to replicate	9
defective interfering particles of	9
the m and s	9
cd c cells within	9
the spike gene of	9
was obtained from the	9
properties of the virus	9
in the number of	9
these results suggested that	9
a result of the	9
viral antigen in the	9
an extended host range	9
the expression level of	9
proteins of the coronavirus	9
has been identified as	9
coterminal nested set of	9
growth of a murine	9
structure and genome expression	9
as demonstrated by the	9
activity by murine hepatitis	9
a portion of the	9
cells were washed twice	9
development of a mouse	9
the endoplasmic reticulum and	9
in the brain stem	9
will be discussed in	9
supplemented with fetal bovine	9
critical role in the	9
demyelination determinants map to	9
in the s protein	9
mouse hepatitis virus by	9
was similar to that	9
in addition to its	9
produced by a temperature	9
stranded rna virus of	9
nested set of subgenomic	9
mutant of hnrnp a	9
hepatitis virus a mrna	9
in the mhv genome	9
mhv infection in the	9
the brains of mhv	9
cd t cell epitope	9
role of rnase l	9
does not seem to	9
a significant role in	9
sets of dbt cells	9
serves as a receptor	9
as a contaminant of	9
white matter of the	9
is required for the	9
conserved polymerase is expressed	9
the mouse central nervous	9
in mice persistently infected	9
nervous system disease by	9
binding domain in the	9
of the ea fraction	9
infected at an moi	9
were added to the	9
synthesis and processing of	9
control and the murine	9
of the jhm strain	9
the e protein of	9
the spike protein of	9
national multiple sclerosis society	9
diarrhea in infant mice	9
and a number of	9
the final conformational change	9
the e protein is	9
determinants map to the	9
with regard to the	9
the spike proteins of	9
the reaction was stopped	9
in the mouse central	9
strains of mhv are	9
may be important for	9
a s gene with	9
effect of mutations in	9
of the viral replicase	9
the he protein of	9
were detected in the	9
were shown to be	9
cleavage of the s	9
third of the genome	9
is transported to the	9
cells were inoculated with	9
at the orf a	9
similar to those observed	9
may be associated with	9
from c h st	9
cd c t cell	9
structural protein that is	9
of vesicular stomatitis virus	9
expression in the central	9
the mhv s glycoprotein	9
the ability of a	9
is a determinant of	9
of laboratory mice and	9
cholesterol and fatty acid	9
the severity of the	9
site within the amino	9
a wide range of	9
characterization of an efficient	9
were washed twice with	9
required for mhv replication	9
well as in the	9
wild type and mutant	9
the cells were fixed	9
the association of m	9
play a significant role	9
of mice and rats	9
proteinase of murine coronavirus	9
the pca response of	9
demyelinating strain of mouse	9
infected cells was shifted	9
ts mutants of mhv	9
is used as a	9
colonies in the usa	9
in animals treated with	9
largest rna virus genome	9
a highly conserved polymerase	9
for an rna pseudoknot	9
be recovered from the	9
the properties of the	9
appears to be a	9
to better understand the	9
structural proteins of the	9
porcine epidemic diarrhea virus	9
the chimeric spike gene	9
in mhv rna synthesis	9
in close proximity to	9
of the nasal mucosa	9
investigate the role of	9
after jhm virus infection	9
glycoprotein of mouse hepatitis	9
in a viral model	9
type of viral glycoprotein	9
have been used to	9
of gene ly e	9
in support of this	9
glycoprotein of coronavirus mouse	9
protein that is not	9
play a critical role	9
binding site within the	9
of influenza c virus	9
infectious bronchitis virus in	9
in accordance with the	9
as a template for	9
protein was found to	9
interactions between s and	9
in a standard plaque	9
expression of viral envelope	9
rna and proteins from	9
map to the spike	9
c cells within the	9
sequence of the genome	9
on the role of	9
of mhv has been	9
could be detected in	9
be responsible for the	9
coronavirus ribosomal frameshifting signal	8
of the pathogenesis of	8
and recurring demyelination produced	8
we have shown previously	8
characterization of a serine	8
type parallels disease susceptibility	8
and translation of a	8
are functional receptors for	8
be used to monitor	8
s subunit of the	8
to the outcome of	8
surface of infected cells	8
in the center of	8
the life cycle of	8
that are responsible for	8
the middle of the	8
differences in proteolytic cleavage	8
nonstructural proteins and rna	8
of hnrnp a dc	8
is related to the	8
virus nonstructural proteins and	8
cd c and cd	8
cells incubated at the	8
from a j mice	8
were found in the	8
persistently infected with mouse	8
mouse hepatitis virus expressing	8
protein of the coronavirus	8
at day post infection	8
and middle east respiratory	8
the exit from the	8
transmissible murine colonic hyperplasia	8
has also been observed	8
demyelination in mice infected	8
mrna mrna mrna mrna	8
of precursors and proteolytic	8
interaction with the viral	8
and proteolytic processing in	8
translation and processing of	8
amino acid substitution in	8
murine neuron as the	8
with feline infectious peritonitis	8
synthesis indicates a role	8
the surface of infected	8
in proteolytic cleavage and	8
the severity of demyelination	8
from the coronavirus group	8
of the myelin sheath	8
during the first weeks	8
neuron as the susceptible	8
a genetic recombination map	8
that the ability of	8
the m protein was	8
the s subunit of	8
demyelinating and nondemyelinating strains	8
and proteolytic products spanning	8
cells were cultured in	8
infected c h hej	8
conserved features of genome	8
recurring demyelination produced by	8
mm cranial and mm	8
proteolytic products spanning kilodaltons	8
the h time point	8
the golgi complex and	8
cells infected with mouse	8
was considered statistically significant	8
hepatitis virus type parallels	8
proteins processed from the	8
of the innate immune	8
produced by infection at	8
the replication of mhv	8
the genome organization of	8
type i ifn signalling	8
strand rna synthesis and	8
the first weeks of	8
of coronavirus defective interfering	8
was performed using the	8
to investigate whether the	8
the plasma membrane of	8
the large size of	8
family are functional receptors	8
the organ tropism of	8
cns tissue by fluorescence	8
proteins and rna synthesis	8
during persistent infection in	8
from the perspective of	8
the relationship between the	8
commonly referred to as	8
on the pathogenesis of	8
it has been demonstrated	8
in the production of	8
result is consistent with	8
murine coronavirus in transformed	8
was also shown to	8
with the presence of	8
is dependent on the	8
and mutant mouse hepatitis	8
indicates a role for	8
the absence of ifn	8
moi of pfu cell	8
cd cd regulatory t	8
fcwf cells transfected with	8
plaque assay on l	8
defective interfering rnas of	8
as well as with	8
on the immune system	8
room temperature for min	8
rna synthesis in mhv	8
site of virion budding	8
to monitor murine coronavirus	8
c bl mice are	8
there appears to be	8
late endosomes in viral	8
hypervariable region of the	8
coronavirus in the absence	8
a mouse model of	8
been shown to have	8
and rna synthesis indicates	8
in a number of	8
as early as h	8
it is noteworthy that	8
dependent differences in proteolytic	8
peripheral blood mononuclear cells	8
mm caudal to the	8
functional receptors for the	8
is dependent on dose	8
disease susceptibility in mice	8
infected cells incubated at	8
structures from coronavirus particles	8
genetic resistance to mouse	8
parallels disease susceptibility in	8
infection of neonatal mice	8
internal open reading frame	8
neutralizing epitopes and the	8
mhv has been shown	8
the synthesis of negative	8
rna species of two	8
course of the infection	8
for their ability to	8
of an efficient coronavirus	8
a reverse genetics system	8
off from the coronavirus	8
during the early phase	8
spread in vitro and	8
is located in the	8
of the largest rna	8
mice chronically infected with	8
retained in the golgi	8
induced fatal central nervous	8
in bovine coronavirus defective	8
intracellular rna species of	8
cells within the cns	8
has not been demonstrated	8
of these two viruses	8
receptors for the coronavirus	8
organ tropism of mouse	8
play important roles in	8
are responsible for the	8
the cns of infected	8
isolation and identification of	8
to that of mhv	8
for at least weeks	8
cranial and mm caudal	8
is shed in faeces	8
proteinases and proteolytic processing	8
the size of the	8
on the mechanism of	8
t cells and macrophages	8
mhv infection of ccl	8
major histocompatibility complex class	8
green fluorescent protein expression	8
monitor murine coronavirus spread	8
have demonstrated that the	8
an important determinant of	8
for autoproteolytic cleavage of	8
that there is a	8
the ability of mhv	8
infected c h mice	8
murine hepatitis virus infection	8
be important in the	8
the murine coronavirus rna	8
of porcine transmissible gastroenteritis	8
end of genomic rna	8
the reader is referred	8
protein expression may be	8
has been demonstrated to	8
be inoculated into mice	8
by infection at ph	8
of a new coronavirus	8
system disease by mouse	8
proteolytic processing in the	8
may occur as a	8
of the development of	8
and conserved features of	8
in prkdc scid mice	8
for late endosomes in	8
at the university of	8
the absence of a	8
of influenza a virus	8
encoding region of the	8
were seen in the	8
the pellet was resuspended	8
central nervous system in	8
hsp bind to the	8
in mice and rats	8
of mouse colonies examined	8
were inoculated with mhv	8
in any of the	8
resistance of mice to	8
domain required for autoproteolytic	8
the balb c mice	8
protein is an endoribonuclease	8
considered to be the	8
van dinten et al	8
murine coronavirus spread in	8
genetic marker of nidoviruses	8
is very similar to	8
the a and b	8
by the observation that	8
of the small intestine	8
resistance to fatal central	8
from a lethal mhv	8
with the ability of	8
mouse hepatitis virus replicase	8
acid substitutions in the	8
essential for virus replication	8
transported to the cell	8
the use of the	8
coronavirus defective interfering rnas	8
murine hepatitis virus replication	8
the oas rnase l	8
susceptible to infection with	8
a role for late	8
not essential for virus	8
rna recombination of murine	8
an efficient coronavirus ribosomal	8
the centers of syncytia	8
this is consistent with	8
processing in the nidovirales	8
persistence and recurring demyelination	8
type i ifn responses	8
ps rna and proteins	8
may be used to	8
like structures from coronavirus	8
within the cns of	8
axonal transport of virus	8
data are presented as	8
these data demonstrate that	8
with the viral nucleocapsid	8
the ectodomain of the	8
the white matter of	8
used to study the	8
a model for multiple	8
de vries et al	8
in cns tissue by	8
endosomes in viral replication	8
based secondary structure prediction	8
spinal cord and optic	8
with a diameter of	8
in cell culture and	8
cd t cell responses	8
coronavirus in transformed mouse	8
genome and proteome of	8
is required for viral	8
committee on taxonomy of	8
the inoculum was removed	8
precursors and proteolytic products	8
over a period of	8
is not clear whether	8
for the coronavirus mouse	8
sites of virion assembly	8
there was no evidence	8
as a consequence of	8
targeted rna recombination and	8
the extended host range	8
the h d mutation	8
the spread of virus	8
mutant mouse hepatitis virus	8
as evidenced by the	8
infected with icwt or	8
phase of the disease	8
vitro transcription and translation	8
pp a pp ab	8
the genomic rna is	8
in vitro transcription and	8
the mhv m protein	8
of two murine coronaviruses	8
have been observed in	8
the replication of the	8
to stimulate class i	8
the largest rna viruses	8
active in viral rna	8
is mediated by the	8
has been proposed to	8
the epithelial cells of	8
and weakly neurotropic a	8
the susceptible site of	8
were isolated from the	8
the leader rna sequence	8
structural proteins of mhv	8
by the fact that	8
in the synthesis of	8
is in agreement with	8
have been implicated in	8
variants of murine coronavirus	8
conformational change in the	8
and serves as a	8
the spinal cord of	8
mouse hepatitis virus s	8
can also be used	8
features of genome and	8
macrophages and dendritic cells	8
in the expression of	8
and severe acute respiratory	8
by polymerase chain reaction	8
to fatal central nervous	8
of human coronavirus oc	8
the genomic rna of	8
products spanning kilodaltons of	8
a single amino acid	8
the coronavirus group lineage	8
inoculated fcwf cells transfected	8
infection in immunodeficient mice	8
or cd t cells	8
incubated at c for	8
of targeted rna recombination	8
at the plasma membrane	8
mrna synthesis involves fusion	8
mouse hepatitis virus replication	8
hamster cell lines confers	8
type and mutant mouse	8
biomedical research viral and	8
to play an important	8
the murine neuron as	8
infection in mice is	8
early stage of infection	8
spleen and lymph nodes	8
are highly susceptible to	8
the presence of mhv	8
hepatitis virus nonstructural proteins	8
the viral life cycle	8
the coronavirus spike protein	8
n protein translated from	8
of murine coronavirus mouse	8
may be accompanied by	8
localization of wild type	8
and mm caudal to	8
the results show that	8
recombination of murine coronaviruses	8
in transformed mouse cells	8
required for autoproteolytic cleavage	8
were introduced into the	8
is expressed in the	8
the production of ifn	8
jhmv and weakly neurotropic	8
our results indicate that	8
due to mouse hepatitis	8
of s a a	8
washed with pbs and	8
cd t cells and	8
been demonstrated in the	8
expression may be used	8
cells were infected at	8
specific intracellular rna species	8
for viral replication in	8
and hamster cell lines	8
to the fact that	8
n a icv at	8
infected cells in the	8
is processed from the	8
have the capacity to	8
to be the most	8
the major histocompatibility complex	8
are found in the	8
involves fusion of non	8
three times with pbs	8
secondary structure prediction of	8
immune response to mhv	8
syndrome coronavirus nonstructural protein	8
at each time point	8
protein of bovine coronavirus	8
cells were washed three	8
replicate in the liver	8
selective localization of wild	8
disease by mouse hepatitis	8
also can be detected	8
is important to note	8
immunodefi ciency virus type	8
structure and function of	8
accumulate in the golgi	8
see materials and methods	8
has been observed in	8
virus persistence and recurring	8
dispensable for viral replication	8
e glycoprotein of mhv	8
induced by murine hepatitis	8
the avian infectious bronchitis	8
exit from the trans	8
used to monitor murine	8
identification of precursors and	8
in the golgi region	8
to the golgi apparatus	8
of ibv and mhv	8
mutation in the coronavirus	8
light and electron microscopy	8
related glycoprotein family are	8
role for late endosomes	8
antigens in cns tissue	8
the n protein has	8
at and h p	8
human and hamster cell	8
was determined using the	8
processed from the gene	8
of genome and proteome	8
the observation that the	8
mhc class i molecules	8
virus type parallels disease	8
coronavirus nucleocapsid protein and	8
infection in the central	8
have not been identified	8
it is tempting to	8
was carried out using	8
and expression of genome	8
in the lungs of	8
such as balb c	8
the distribution of the	8
rna synthesis indicates a	8
virus in the cns	8
and biochemical characterization of	8
to be inoculated into	8
fluorescent protein expression may	8
the mutant hnrnp a	8
alb ts icv at	8
rna of strongly neurotropic	8
was not affected by	8
as the susceptible site	8
we have demonstrated that	8
of the n gene	8
in of mouse colonies	8
of antigenic variants of	8
that is not essential	8
at h after infection	8
coronavirus spread in vitro	8
reader is referred to	8
syndrome coronavirus replication complex	8
will be required to	8
coronavirus transmissible gastroenteritis virus	8
has been found to	8
monolayers of l cells	8
of rna recombinant viruses	8
region of the murine	8
selected with monoclonal antibodies	8
the level of the	8
is targeted to the	8
to infection with mhv	8
on taxonomy of viruses	8
were stained with hematoxylin	8
colonies of laboratory mice	8
of strongly neurotropic jhmv	8
retention in the golgi	8
the synthesis of a	8
characterization of a human	8
the intensity of the	8
by plaque assay in	8
in spinal cord grey	8
is antigenically related to	8
model for multiple sclerosis	8
of the nucleocapsid protein	8
species of two murine	8
genetically susceptible and resistant	8
glycoprotein family are functional	8
mutations in nsp and	8
to lethal infection with	8
the constitutive exocytic pathway	8
mice after jhm virus	8
bovine coronavirus defective interfering	8
unique and conserved features	8
behavior in vitro and	8
in jhm virus encephalomyelitis	8
human immunodefi ciency virus	8
of the interaction between	8
synthesis involves fusion of	8
susceptible site of disease	8
the case of the	8
an early stage of	8
with tcid of mhv	8
will be needed to	8
terminal region of the	7
other organs such as	7
is derived from the	7
selected mutants of mouse	7
nucleocapsid protein of the	7
hepatitis virus mouse hepatitis	7
the same complementation group	7
of the international committee	7
in the cell periphery	7
a variety of tissues	7
a better understanding of	7
antigenic variants of murine	7
and adjacent to sites	7
within the cln of	7
nervous system tissue of	7
virus to replicate in	7
of the brain and	7
a deletion mutant of	7
as a negative control	7
formation of the viral	7
of nidoviruses encodes a	7
protein and viral rnas	7
the analysis of the	7
frame within the nucleocapsid	7
the orf a b	7
murine hepatitis virus is	7
with that of the	7
cells infected with murine	7
the spinal cord white	7
genetic analysis of murine	7
a low level of	7
and murine hepatitis virus	7
experimental allergic encephalomyelitis in	7
of the mhv spike	7
c bl mice infected	7
mouse hepatitis virus colocalize	7
were subjected to immunoprecipitation	7
between the leader rna	7
interaction of mouse hepatitis	7
which is known to	7
human respiratory syncytial virus	7
nervous system requires both	7
on dose and route	7
be important for the	7
the mhv spike gene	7
signal in the polymerase	7
the beginning of the	7
for up to months	7
s gene of mhv	7
mice are highly susceptible	7
nasal epithelial cells as	7
data suggest that mhv	7
evidence for the role	7
subgenomic mouse hepatitis virus	7
in the spleen and	7
mechanism of demyelination in	7
both in vitro and	7
bacteriophage t rna polymerase	7
spike gene of murine	7
model for the study	7
of s from s	7
open reading frame within	7
between the m and	7
in c h mice	7
in the middle of	7
biomedical research the mouse	7
the case of sars	7
to the n protein	7
or bhk mceacam a	7
involved in coronavirus rna	7
between ps rna and	7
aminopeptidase n is a	7
were derived from the	7
the existence of a	7
copies of replicating coronavirus	7
the orf a peptide	7
linked immunosorbent assay for	7
end of the polymerase	7
the mouse carcinoembryonic antigen	7
histocompatibility complex class i	7
due to the lack	7
the early stages of	7
and interaction with the	7
gene encoding the surface	7
of most of the	7
and its role in	7
mice are relatively resistant	7
replication of coronavirus mhv	7
structure and translation of	7
an moi of pfu	7
a proteins of the	7
coronavirus mrna synthesis involves	7
the wt hnrnp a	7
in the lumen of	7
in mouse spinal cord	7
incorporated into virus particles	7
mouse hepatitis virus replicative	7
a defective interfering rna	7
demyelination induced by mouse	7
the transmissible gastroenteritis coronavirus	7
that dn t cells	7
the production of recombinant	7
shown to interact with	7
in the liver of	7
four proteins processed from	7
of these small rnas	7
the results of the	7
is due to the	7
of nasal epithelial cells	7
to a variety of	7
the hd c site	7
within the spike gene	7
of the bovine coronavirus	7
structural elements in the	7
hsp and hsp bind	7
we observed that the	7
indications for rna recombination	7
localization and membrane topology	7
in the assembly of	7
entry into the cns	7
to be critical for	7
the processing of the	7
retrograde axonal transport of	7
c cd b cd	7
strains of the coronavirus	7
the evolution of life	7
as shown in table	7
like cysteine proteinase of	7
susceptibility to mouse hepatitis	7
of demyelination in jhm	7
the pathogenesis of the	7
and shown to be	7
genes are not essential	7
or nsp mutant viruses	7
mice were obtained from	7
monolayers of dbt cells	7
manganese as a cofactor	7
this study was to	7
of l cells in	7
susceptible to lethal infection	7
reading frame within the	7
be required for viral	7
cells were fixed with	7
nondemyelinating strains of mouse	7
at days and p	7
glycoprotein gene of mhv	7
research the mouse in	7
coronavirus nonstructural protein ns	7
suppresses host gene expression	7
with fetal calf serum	7
in mice is dependent	7
that cd t cells	7
may be found in	7
shown to bind to	7
the endogenous hnrnp a	7
supported by a reticulovesicular	7
assay for detection of	7
the potential for mrna	7
and incubated for hr	7
proteins accumulate in the	7
member of the genus	7
induces type i interferon	7
sars coronavirus nonstructural protein	7
previous studies have shown	7
animal care and use	7
the internal open reading	7
for di rna replication	7
coronaviruses isolated from central	7
cells were isolated from	7
of ibv h bi	7
to infection by mhv	7
care and use committee	7
of murine hepatitis viruses	7
s gene of the	7
rna in infected cells	7
translation of a defective	7
colocalize in the cell	7
nsp was shown to	7
to play a role	7
mice are susceptible to	7
type i ifn receptor	7
even in the absence	7
presence of viral antigen	7
biological behavior in vitro	7
cleavage and cell fusion	7
gene polyprotein of mouse	7
the synthesis of viral	7
prefers manganese as a	7
protein of murine coronaviruses	7
persistent infection with mouse	7
the carboxy terminus of	7
cd or cd t	7
it appears that the	7
charged residues in the	7
nonstructural protein ns is	7
encoded proteinases and proteolytic	7
particles of a murine	7
secondary site mutations in	7
replicative intermediates function in	7
may reflect differences in	7
adjacent to sites of	7
results demonstrate that the	7
because the virus is	7
in nsp dc virus	7
also can be used	7
was performed with the	7
and replication of coronaviruses	7
replacement of the mhv	7
the primary means of	7
cells present within the	7
in different cell types	7
rough endoplasmic reticulum and	7
coronavirus genome structure and	7
of some of these	7
rna structural elements in	7
domains in the non	7
reticulovesicular network of modified	7
and stained with hematoxylin	7
by a neurotropic murine	7
novel coronavirus associated with	7
weakly neurotropic a v	7
induction of monocyte procoagulant	7
have previously shown that	7
a icv at an	7
coronavirus leader rna and	7
mrnas of mouse hepatitis	7
upper respiratory tract disease	7
research viral and mycoplasmal	7
a reticulovesicular network of	7
have been found in	7
the first days after	7
disease is modulated in	7
in gene of the	7
role in the pathogenesis	7
rule out the possibility	7
responsible for the observed	7
in the natural host	7
in laboratory mice and	7
both of which are	7
the host range of	7
leader rna and nucleocapsid	7
whether or not the	7
localizes in complexes that	7
virus replicative intermediates function	7
efficient coronavirus ribosomal frameshifting	7
regulation of bnip expression	7
spike glycoprotein of murine	7
high levels of virus	7
and identification of virus	7
mouse spinal cord cultures	7
for murine coronavirus replication	7
of the genomes of	7
the innate immune system	7
virus colocalize in the	7
were infected at a	7
in their susceptibility to	7
the biological significance of	7
nt upstream of the	7
of the coronavirus peplomer	7
protein interactions of the	7
although it is not	7
that prefers manganese as	7
a log reduction factor	7
members of the mouse	7
reaction was stopped by	7
have been found to	7
comparable to that of	7
coronaviruses in group ii	7
numbers of cd a	7
putative helicase of the	7
recombination within the spike	7
the data presented in	7
had no effect on	7
oas rnase l pathway	7
in the same way	7
the nucleocapsid gene of	7
analysis of the sars	7
the putative helicase of	7
measured by plaque assay	7
innate and adaptive immunity	7
in complexes that are	7
were purchased from the	7
are active in viral	7
to be due to	7
infection by a neurotropic	7
containing fetal calf serum	7
infectious bronchitis virus is	7
the lumen of the	7
under the electron microscope	7
in the spike gene	7
and translation of the	7
golgi network of att	7
infection mouse hepatitis virus	7
a significant increase in	7
three strains of mice	7
to investigate the role	7
performed as previously described	7
the glycoprotein e of	7
the critical role of	7
lr cells infected with	7
h a replication was	7
proteolytic cleavage and cell	7
demyelination in jhm virus	7
with the appearance of	7
were incubated for min	7
replicase gene polyprotein of	7
of recombinant infectious di	7
in a mouse model	7
lymphocytic choriomeningitis virus in	7
demyelination induced by coronavirus	7
of the glycoprotein e	7
cells of the cns	7
t cell response to	7
infected ccl and ccl	7
have been demonstrated to	7
other members of the	7
and visualized by autoradiography	7
murine coronavirus nonstructural protein	7
is composed of a	7
for the duration of	7
of an rna virus	7
in rna replication and	7
in place of the	7
and appears to be	7
system requires both cd	7
defective interfering rna of	7
tropism and expression of	7
to viral infection of	7
within the nucleocapsid gene	7
interaction between m and	7
was also observed in	7
a novel coronavirus associated	7
isolated from central nervous	7
protein of feline infectious	7
there is some evidence	7
added to each well	7
within the s gene	7
ph dependence of coronavirus	7
on the plasma membrane	7
for the formation of	7
a model for the	7
compared to wt mhv	7
structural polypeptides of the	7
coronavirus mrnas contain antileaders	7
of the murine hepatitis	7
endoribonuclease that prefers manganese	7
molecular weights of the	7
cell lysates were prepared	7
similar to that in	7
hepatitis virus colocalize in	7
demyelination in the spinal	7
of infected cells and	7
of the viral replication	7
overexpression of the wt	7
belonging to the family	7
of the present study	7
phosphoproteins of murine hepatitis	7
q is a determinant	7
and localizes in complexes	7
is shown in table	7
gene expression in the	7
virus of the family	7
the open reading frame	7
could not be recovered	7
la monica et al	7
replicating coronavirus mrnas contain	7
and genetic localization of	7
this is the first	7
and incubated for min	7
end of mouse hepatitis	7
and has been shown	7
of the rough endoplasmic	7
genetic localization of the	7
hepatitis virus is processed	7
the upper respiratory tract	7
that all of the	7
sensitive mutants of mhv	7
between the n protein	7
for min and then	7
to the number of	7
production of recombinant infectious	7
cell periphery and adjacent	7
of minute virus of	7
protein processed from the	7
respiratory syndrome coronavirus spike	7
coronavirus associated with severe	7
of the polymerase polyprotein	7
in the cns and	7
between viral envelope and	7
recombinant vaccinia virus expressing	7
cd t cells have	7
control and prevention of	7
in the study of	7
likely due to the	7
two coronaviruses isolated from	7
mice as compared to	7
virus infection in mice	7
was reported to be	7
at the junction between	7
the cytoplasm of mhv	7
to sites of virion	7
potential for mrna replicons	7
not yet been identified	7
of the host cell	7
site of budding of	7
replication is supported by	7
to multiple nucleoside analogues	7
ts and alb ts	7
of the coronavirus m	7
in the control of	7
coronavirus nsp protein is	7
can occur in the	7
central nervous system tissue	7
for rna recombination between	7
type i interferon in	7
are not required for	7
complexes that are active	7
inoculum was removed and	7
the presence of this	7
natural or experimental infection	7
by the finding that	7
leader rna sequences on	7
n protein has been	7
and expression of mouse	7
present within the cns	7
cells mouse hepatitis virus	7
within the s glycoprotein	7
an incubation period of	7
mouse hepatitis virus nucleocapsid	7
the course of an	7
virus strain a from	7
may be mediated by	7
glycoproteins and interaction with	7
after an incubation period	7
can be accomplished by	7
electron microscopic studies of	7
the leader rna of	7
a simple method of	7
in liver and spleen	7
infection with ectromelia virus	7
molecular cloning of the	7
in vitro and virus	7
pathogenesis of chimeric mhv	7
was also detected in	7
to cause persistent infection	7
is essential for the	7
intracellular processing of the	7
s and s subunits	7
has recently been shown	7
would be expected to	7
of the molecular biology	7
electron microscope study of	7
to the lack of	7
polyprotein of mouse hepatitis	7
viruses from patients with	7
the involvement of the	7
by public health service	7
support the hypothesis that	7
the n protein in	7
at different time points	7
host gene expression by	7
from the brains of	7
central nervous system during	7
in the amount of	7
cleavage site recognized by	7
the possible presence of	7
in the reticulocyte lysate	7
syndrome coronavirus spike protein	7
virus encodes a structural	7
of the chimeric spike	7
chemokines and chemokine receptors	7
conformational changes in the	7
samples at d p	7
type i interferon response	7
side of the golgi	7
a determinant of hepatotropism	7
by the lack of	7
that are active in	7
is involved in the	7
encoding the surface projection	7
hepatitis virus from the	7
infection of mice by	7
is shown in figure	7
the presence of nhc	7
the result of a	7
bind to the mhv	7
effect of cc on	7
was kindly provided by	7
incubation at room temperature	7
virus titers in liver	7
synthesis of viral rna	7
compared to sjl mice	7
for the nucleocapsid protein	7
do not appear to	7
was supported by a	7
the result showed that	7
to the leader rna	7
the morphology of the	7
envelope glycoproteins and interaction	7
balb and sjl mice	7
the mhv model of	7
does not result in	7
p and p positions	7
infection in laboratory mice	7
at least one of	7
is found in the	7
as early as hr	7
lymphocytic choriomeningitis virus infection	7
nidoviruses encodes a replicative	7
results are shown in	7
cysteine proteinase of murine	7
to those observed in	7
major genetic marker of	7
be noted that the	7
with the majority of	7
structure and genetic localization	7
with mutations in the	7
replication in the cns	7
with upper respiratory tract	7
the p cleavage site	7
transmission has not been	7
were incubated for h	7
an endoribonuclease that prefers	7
the mrna start sites	7
protein nsp is a	7
pathogenicity of antigenic variants	7
of replicating coronavirus mrnas	7
electron microscopic study of	7
the viral structural proteins	7
localization of the sequence	7
coronavirus spike protein by	7
was cloned into the	7
viral hepatitis in mice	7
are listed in table	7
the leader sequence and	7
dependent on dose and	7
the m s complexes	7
network of att cells	7
encodes a replicative endoribonuclease	7
of mhv infection is	7
our data suggest that	7
nucleocapsid protein and viral	7
of the membrane and	7
mouse hepatitis virus encodes	7
and membrane topology of	7
of human immunodeficiency virus	7
deletion mutant of the	7
hepatitis virus replicative intermediates	7
network of modified endoplasmic	7
did not result in	7
effective clearance of mouse	7
were incubated with the	7
the right of the	7
as a model of	7
mice of all ages	7
clinical signs and lesions	7
of leader rna sequences	7
mouse hepatitis virus mouse	7
that had been infected	7
a structural protein that	7
hepatitis virus nucleocapsid protein	7
its retention in the	7
activation of the coagulation	7
on cl cell monolayers	7
of avian coronavirus infectious	7
cells were incubated for	7
in the loss of	7
a nested set of	7
between mhv and ibv	7
wk of age had	7
characterization of mouse hepatitis	7
that are involved in	7
n protein and the	7
the relative abundance of	7
of sars coronavirus rna	7
as a positive control	7
in the viral genome	7
multiple regions of the	7
conserved in s of	7
the brains of mice	7
cl or bhk mceacam	7
has the capacity to	7
is an endoribonuclease that	7
at h and h	7
of the virus on	7
and nondemyelinating strains of	7
cell tropism and expression	7
by a reticulovesicular network	7
of the mouse carcinoembryonic	7
susceptibility to mhv infection	7
kilodaltons of orf a	7
required for viral clearance	7
persistently infected glial cells	7
and c h mice	7
alt and ast levels	7
after experimental inoculation of	7
neurotropic a v viruses	7