This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-030961-5gzc7193 | Influenza virus binds its host cell using multiple dynamic interactions How does a virus bud? |
| cord-015866-65zrbo1w | symporter: mechanical switch or brownian ratchet? |
| cord-279463-bli8hwda | How can we possibly explain how the deletion of the cytoplasmic, hydrophilic segment from IyCAT reveals a cleavable signal sequence in a formerly membranespanning region? |
| cord-298019-gf2asni1 | The preference of tryptophan for membrane interfaces Use of hydrophobic moment plot methodology to aid the identification of oblique orientated α- helices Antimicrobial peptides and viral fusion peptides: how different they are? |
| cord-104279-choywmwd | The rate of bulk flow from the Golgi to the plasma membrane Protein degradation in the endoplasmic reticulum Membrane protein sorting: biosynthesis, transport, and processing of yeast vacuolar alkaline phosphatase A new class of lysosomal/ vacuolar protein sorting signals Protein glycosylation in yeast Rapid and efficient sitespecific mutagenesis without phenotypic selection Structure of a yeast pheromone gene( MFa): a putative a- factor precursor contains four tandem copies of mature c~-factor Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endoeytosis Golgi retention signals: do membranes hold the key? |
| cord-303238-us3dybue | Why does MHV PLP2 require membrane association for proteolytic processing of the PLP2 cleavage site? |
| cord-285620-oawrnmhy | Antibacterial electrospun chitosan/ poly( vinyl alcohol) nanofibers containing silver nitrate and titanium dioxide New directions in nanofiltration applications- are nanofibers the right materials as membranes in desalination? |
| cord-000884-zq8kqf6h | But is there a model membrane system that is the best for membrane- protein reconstitution? |
| cord-000884-zq8kqf6h | Why use half a membrane to characterize protein- membrane interactions? |
| cord-336929-2rnkotqy | key: cord-336929- 2rnkotqy authors: Vieira, Flávia Sarmento; Corrêa, Gladys; Einicker‐Lamas, Marcelo; Coutinho‐Silva, Robson title: Host‐cell lipid rafts: a safe door for micro‐organisms? |
| cord-022354-aqtceqqo | Thus even in this well- defined situation, where an amino acid sequence is known to play a functional role in the sorting process, it can be impossible to predict with confidence its location in the protein; how then might we expect to identify additional sorting sequences that may or may not exist within the structural domain of a transported protein? |
| cord-022354-aqtceqqo | What then is the function of the cytoplasmic domain of the env glycoprotein? |
| cord-287093-9mertwj7 | Aggresomes resemble sites specialized for virus assembly Aggresomes and pericentriolar sites of virus assembly: cellular defense or viral design? |
| cord-287093-9mertwj7 | The human fatty acid synthase: a new therapeutic target for coxsackievirus B3-induced diseases? |
| cord-339172-210dwhgj | if RNA synthesis would indeed occur inside closed DMVs or VPs, how then are import and export across the double membrane achieved? |
| cord-284690-ogu1gmcb | Antimicrobial and host- defense peptides as new anti- infective therapeutic strategies Antimicrobial peptides( AMPs) as drug candidates: a patent review Quality specifications for peptide drugs: a regulatorypharmaceutical approach Antimicrobial peptides stage a comeback Future directions for peptide therapeutics development Rational design of engineered cationic antimicrobial peptides consisting exclusively of arginine and tryptophan, and their activity against multidrug- resistant pathogens Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? |
| cord-284690-ogu1gmcb | Can innate immunity be enhanced to treat microbial infections? |
| cord-103739-mmkrwj8t | Do viruses subvert cholesterol 863 homeostasis to induce host cubic membranes? |
| cord-103739-mmkrwj8t | Replication Organelle Comprises Double- Membrane Vesicles and Zippered Endoplasmic 766 Does form meet function in the 769 coronavirus replicative organelle? |
| cord-274101-vm9nh8lc | Membrane fluidity characteristics of human lung cancer Heparan sulfate: anchor for viral intruders? |
| cord-274101-vm9nh8lc | Nisin diffusion in protein films: effects of film type and temperature Influence of amino acid substitutions in the nisin leader peptide on biosynthesis and secretion of nisin by Lactococcus lactis Antiviral activities of lactoferrin Natural products with hypoglycemic, hypotensive, hypocholesterolemic, antiatherosclerotic and antithrombotic activities Expression and purification of antimicrobial peptide buforin IIb in Escherichia coli Lantibiotics: peptides of diverse structure and function Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli Barrel- stave model or toroidal model? |
| cord-103812-ls6zgipi | What vesicles initially fuse with the connexosomes? |
| cord-103812-ls6zgipi | and what is its purpose? |
| cord-338827-1moy43hr | How does a biological membrane accomplish semipermeability? |
| cord-338827-1moy43hr | What are aquaporins for? |
| cord-269756-tid8a464 | At this concentration, what are the changes in the structural dynamics, curvature and hydration of the lipids and in the thermodynamic parameters of the membranes that lead to membrane fusion? |
| cord-269756-tid8a464 | a hairpin Structure and function of membrane fusion peptides Are fusion peptides a good model to study viral cell fusion? |
| cord-013223-f43hks44 | A human gut microbial gene catalogue established by metagenomic sequencing Are we really vastly outnumbered? |
| cord-013223-f43hks44 | The biology, function, and biomedical applications of exosomes Current understanding of the human microbiome Membrane vesicle release in bacteria, eukaryotes, and archaea: a conserved yet underappreciated aspect of microbial life Virulence and immunomodulatory roles of bacterial outer membrane vesicles Extracellular vesicle RNA: a universal mediator of microbial communication? |
| cord-013223-f43hks44 | The healthy human blood microbiome: fact or fiction? |
| cord-330110-pamxy4av | ( TIF) Identification of hepatoprotective flavonolignans from silymarin Multiple effects of silymarin on the hepatitis C virus lifecycle Silibinin and related compounds are direct inhibitors of hepatitis C virus RNAdependent RNA polymerase Synthesis and in vitro anti- hepatitis B virus activities of some ethyl 6-bromo-5-hydroxy-1H- indole-3-carboxylates Antiviral chemotherapeutic agents against respiratory viruses: where are we now and what's in the pipeline? |
| cord-330110-pamxy4av | Interfacial tryptophan residues: a role for the cation- pi effect? |
| cord-319754-5isw53wl | An Essential"Receptor"or an"Accessory Attachment Factor"for Hepatitis A Virus? PIP5K- driven PtdIns(4,5)P2 synthesis: Regulation and cellular functions Function and dysfunction of the PI system in membrane trafficking PIP2: Choreographer of actin- adaptor proteins in the HIV-1 dance Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring Quantification of phosphoinositides reveals strong enrichment of PIP2 in HIV-1 compared to producer cell membranes Investigation of the Lipid Binding Properties of the Marburg Virus Matrix Protein VP40 Type I phosphatidylinositol-4-phosphate |
| cord-319754-5isw53wl | Signaling Multifaceted roles for lipids in viral infection Ultrastructure of the replication sites of positive- strand RNA viruses Does form meet function in the coronavirus replicative organelle? |
| cord-300429-b0zev8zb | The role of MPP1/ p55 and its palmitoylation in resting state raft organization in HEL cells Membrane raft association is a determinant of plasma membrane localization Palmitoylated transmembrane adaptor proteins in leukocyte signaling Interaction of influenza virus haemagglutinin with sphingolipid- cholesterol membrane domains via its transmembrane domain What does S- palmitoylation do to membrane proteins? |
| cord-300429-b0zev8zb | are enzymes for fatty acid attachment promising drug targets? |
| cord-265887-g5zhoyo9 | Alternatively, does the lipid- composition specificity of the C- terminal determine the conformational uptake and the eventual functional topology? |
| cord-265887-g5zhoyo9 | Do these hydrophobic interactions prompt the downstream oligomerization events to the formation of the membrane- associated multimers? |
| cord-265887-g5zhoyo9 | Does the C- terminal induce the initial docking of the protein to the host membranes? |
| cord-341378-pw60qx7c | Of the two viral membrane proteins, the smaller one, El, is necessary for formation of the envelope, and is restricted to internal cell membranes; apparent?; it only reaches the cell surface as part of the budded virion 12 • 3. |
| cord-341378-pw60qx7c | Which, if any, of these various features might be responsible for the protein's intracellular localization? |
| cord-006556-hmzoxqu3 | ARDS and ECMO, weaning, mechanical ventilation, noninvasive ventilation, pediatrics and miscellanea Pediatric and neonatal extracorporeal membrane oxygenation; does center volume impact mortality? |
| cord-006556-hmzoxqu3 | Congenital diaphragmatic hernia requiring extracorporeal membrane oxygenation: does timing of repair matter? |
| cord-006556-hmzoxqu3 | Data supports the practice of treating each patient for survival regardless of the physiologic severity in the first few hours of life Congenital diaphragmatic hernia: to repair on or off extracorporeal membrane oxygenation? |
| cord-006556-hmzoxqu3 | The Italian ECMO network experience during the 2009 influenza A( H1N1) pandemic: preparation for severe respiratory emergency outbreaks Extracorporeal membrane oxygenation( ECMO) in patients with H1N1 influenza infection: a systematic review and meta- analysis including 8 studies and 266 patients receiving ECMO Extracorporeal membrane oxygenation for pandemic influenza A( H1N1)-induced acute respiratory distress syndrome: a cohort study and propensity- matched analysis Extracorporeal membrane oxygenation in pandemic flu: insufficient evidence or worth the effort? |
| cord-341129-eo0vjcmk | How general is cooperativity? |
| cord-341129-eo0vjcmk | What other classes of viral fusion proteins might there be? |
| cord-014685-ihh30q6f | How important is protein exibility for transport through ion channels? |
| cord-014685-ihh30q6f | Should it be the autonomous course or the part of physiology and radiology courses in the problem based learning approach?! |
| cord-014685-ihh30q6f | The consistency in the formations of these conformations makes the design of peptides with alpha, beta? |
| cord-014685-ihh30q6f | a tug- ofwar or coordinated movement? |
| cord-257754-pqxkyg8z | Biogenesis from scratch? |
| cord-257754-pqxkyg8z | Cvt17/ Aut5p aVect its function? |
| cord-257754-pqxkyg8z | Evidence for fusion of autophagosomes with both early and late endosomes Developmental features of autophagy in aging secretory cells of Tamarix aphylla salt glands Protein degradation in mitochondria: Implications for oxidative stress, aging and disease: A novel etiological classification of mitochondrial proteolytic disorders PpATG9 encodes a novel membrane protein that traYcs to vacuolar membranes which sequester peroxisomes during pexophagy in Pichia pastoris Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth Fulvio Reggiori Autophagy and aging: The importance of maintaining Does autophagy contribute to cell death? |
| cord-257754-pqxkyg8z | These factors have no counterparts in S. cerevisiae or the homologs do not have a role in pexophagy.? |
| cord-028738-ing07qma | Can the pharmaceutical industry reduce attrition rates? |
| cord-028738-ing07qma | Firstly, can existing drugs be repurposed for effective treatment of COVID-19? |
| cord-028738-ing07qma | If so, how their efficacy can be evaluated rapidly? |
| cord-028738-ing07qma | Secondly, what alternative options can be employed to reduce the time of clinical trials by rapid drug testing and approval? |
| cord-006947-nrzjedhi | Can Janus particles give thermodynamically stable pickering emulsions? |
| cord-006947-nrzjedhi | How do mosquito eggs selfassemble on the water surface? |
| cord-006947-nrzjedhi | How should the completeness and quality of curated nanomaterial data be evaluated? |
| cord-006947-nrzjedhi | When do fluid membranes engulf sticky colloids? |
| cord-006947-nrzjedhi | hollow shellshell nanocontainers offer an improved strategy for drug delivery? |
| cord-034898-zjfhpum2 | Extracorporeal membrane oxygenation with multiple- organ failure: can molecular adsorbent recirculating system therapy improve survival? |
| cord-034898-zjfhpum2 | The role of echocardiography in neonates and pediatric patients on extracorporeal membrane oxygenation Cardiopulmonary resuscitation in infants and children with cardiac disease: a scientific statement from the The complex relationship of extracorporeal membrane oxygenation and acute kidney injury: causation or association? |
| cord-034898-zjfhpum2 | Weaning from veno- arterial extra- corporeal membrane oxygenation: which strategy to use? |
| cord-034898-zjfhpum2 | conventional tests, point- of- care, or both? |
| cord-034898-zjfhpum2 | why, when and how? |
| cord-329448-kxxy60x9 | A morphological study of the coated vesicle isolated from the nerve endings of the guinea pig brain, with special reference to the mechanism of membrane movements Cargo regulates clathrincoated pit dynamics Clathrin- dependent mechanisms of G protein- coupled receptor endocytosis Clathrin- coated pits: vive la difference? |
| cord-329448-kxxy60x9 | The BAR- domain family of proteins: a case of bending and binding? |
| cord-329448-kxxy60x9 | Tubular membrane invaginations coated by dynamin rings are induced by GTP- gamma S in nerve terminals Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites Regulatory mechanisms of dynamin- dependent endocytosis Dynamin: switch or pinchase? |
| cord-329448-kxxy60x9 | a raft- mediated mechanism for endocytosis and morphology of caveolae? |
| cord-264996-og3sg0qw | But how does a specific protein''know''how to reach a specific cellular destination when hundreds of newly synthesized, diVerent molecules require 2 specific transport and targeting? |
| cord-264996-og3sg0qw | The Next Generation of Medical Treatment? |
| cord-264996-og3sg0qw | The secrets of secretory lysosomes The biogenesis of lysosomes: Is it a kiss and run, continuous fusion and fission process? |
| cord-264996-og3sg0qw | This raises a key question: how do protein and lipid cargo move through the Golgi apparatus while resident enzymes retain their localization? |
| cord-264996-og3sg0qw | Where is it and what does it do? |
| cord-309384-vlk8cebh | Crystal structure of β- hexosaminidase B in complex with pyrimethamine, a potential pharmacological chaperone Induced secretion of β- hexosaminidase by human brain endothelial cells: a novel approach in Sandhoff disease? |
| cord-309384-vlk8cebh | Do mitochondria act as"cargo boats"in the journey of GD3 to the nucleus during apoptosis? |
| cord-309384-vlk8cebh | Galectin-1 is a major receptor for ganglioside GM1, a product of the growth- controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture Carbohydrate- to- carbohydrate interaction, through glycosynapse, as a basis of cell recognition and membrane organization Carbohydrate- Carbohydrate interaction in basic cell biology Carbohydrate- carbohydrate interactions in cell recognition Specific interaction between gangliotriaosylceramide( Gg3) and sialosyllactosylceramide( G(M3) as a basis for specific cellular recognition between lymphoma and melanoma cells Brain gangliosides in axon- myelin stability and axon regeneration Gangliosides and the multiscale modulation of membrane structure Receptor modifications in glycobiology Neural functions of glycolipids Lipid rafts: keys to neurodegeneration Regulation of human EGF receptor by lipids Gangliosides as components of lipid membrane domains Membrane organization and lipid rafts Revitalizing membrane rafts: new tools and insights Lipid rafts as a membraneorganizing principle Lipids and cholesterol as regulators of traffic in the endomembrane system Principles of microdomain formation in biological membranes- are there lipid liquid ordered domains in living cellular membranes? |
| cord-309384-vlk8cebh | MDR1 Pglycoprotein is a lipid translocase of broad specificity, while MDR3 P- glycoprotein specifically translocates phosphatidylcholine ABC lipid transporters: extruders, flippases, or flopless activators? |
| cord-309384-vlk8cebh | Pathogenic cascades in lysosomal diseasewhy so complex? |
| cord-309384-vlk8cebh | origin and function Nomenclature of glycolipids Neuronal dysfunction with aging and its amelioration Are globoseries glycosphingolipids SSEA-3 and-4 markers for stem cells derived from human umbilical cord blood? |
| cord-020712-l9cn0n99 | As a conventional measure to show the difference in the pH dependence, the pH at half- maximal fusion, pH,,?. |
| cord-020712-l9cn0n99 | Is phosphatidylserine a VSV binding site? |
| cord-020712-l9cn0n99 | Is the primary sequence also essential for the fusion function? |
| cord-020712-l9cn0n99 | L'irolog? |
| cord-020712-l9cn0n99 | Lateral mobility of band 3 proteins in erythrocyte membranes is largely restricted under physiological conditions; the diffusion constant is of the order of cm? |
| cord-020712-l9cn0n99 | Proteolytic cleavage of the E? glycoprotein of murine Coronavirus: Activation of cell- fusing activity of virions by trypsin and separation of two different YOK cleavage |
| cord-020712-l9cn0n99 | Why is a specific amino acid sequence of F glycoprotein required for the membrane fusion reaction between envelope of HVJ( Sendai virus) and target cell membranes? |
| cord-313599-5j19stye | Does the universal law of electrospinning process can be applied to the ESN process? |
| cord-313599-5j19stye | Electrospun nanofibrous structure: a novel scaffold for tissue engineering A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering Electrospun nanofibers: solving global issues Electrospinning of nanofibers: reinventing the wheel? |
| cord-313599-5j19stye | Here, a question may come to mind, how morphology changes for nano- nets when we regulate the solution concentrations? |
| cord-313599-5j19stye | One puzzling question is this: What happens to the charged polymer jets and droplets during their running in such small distance between needle and collector? |
| cord-313599-5j19stye | The charge effect of cationic surfactants on the elimination of fibre beads in the electrospinning of polystyrene Electrospun polyacrylonitrile/ zinc chloride composite nanofibers and their response to hydrogen sulfide Experimental investigation of the governing parameters in the electrospinning of polymer solutions Formation of high aspect ratio polyamide-6 nanofibers via electrically induced double layer during electrospinning Electrospun silk biomaterial scaffolds for regenerative medicine Tunable fabrication of three- dimensional polyamide-66 nano- fiber/ nets for high efficiency fine particulate filtration GaN nanofibers based on electrospinning: facile synthesis, controlled assembly, precise doping, and application as high performance UV photodetector Mechanical and wettable behavior of polyacrylonitrile reinforced fibrous polystyrene mats Deciphering glycan linkages involved in Jurkat cell interactions with gold- coated nanofibers via sugar- displayed thiols Developments in filtration: what is nanofiltration? |
| cord-313599-5j19stye | The main confused problem is this: What happens to the charged polymer jets and droplets during such small distance from tip to collector? |
| cord-313599-5j19stye | Thus from pure geometric viewpoint, we can answer an important question that why do the nano- nets''tend to''be Steiner geometry? |
| cord-020788-a33vcapl | Are different signals recognized by the different epithelial cells or is the same signal interpreted differently? |
| cord-020788-a33vcapl | But if the VSVG ectodomain is randomly secreted and the VSVG tail domain fused to HA is apical, which domain of VSVG encodes basolateral sorting information? |
| cord-020788-a33vcapl | For example, is this cell derived from a tissue specialized for apical secretion or apical endocytosis? |
| cord-020788-a33vcapl | For the epithelial cell biologist, the obvious question is,"What brings about the pathway- specific localizations of rab proteins in polarized epithelial cells?" |
| cord-020788-a33vcapl | Is the sorting machinery itself different between polarized cells, or is the sorting machinery basically conserved between different cell- types while its regulation, adaptation, or wiring to the targeting machinery is different? |
| cord-020788-a33vcapl | Is the tight junction a barrier to diffusion in the plasma membrane? |
| cord-020788-a33vcapl | What does the LDLR gain by expressing two basolateral localization signals? |
| cord-020788-a33vcapl | Why do these proteins need multiple signals? |
| cord-314402-kjzkk51t | For example, what is the driving mechanism for domain aggregation? |
| cord-314402-kjzkk51t | How does the spontaneous curvature of domain affect pore formation? |
| cord-314402-kjzkk51t | How does the vesicle size affect pore formation? |
| cord-314402-kjzkk51t | How to predict the energy barrier and time scales for pore formation? |
| cord-314402-kjzkk51t | What are the effects of homogeneous vs interfacial nucleation of pores? |
| cord-314402-kjzkk51t | Why does domain aggregation facilitate pore formation? |
| cord-314402-kjzkk51t | Why is there a characteristic domain size? |
| cord-346446-i7gpxcyo | How can we tune the length of biosynthesized PMLA? |
| cord-346446-i7gpxcyo | Novel gene- editing techniques are urgently needed that would allow efficient delivery of Given the complications of scalability from bench to industrial pilot plant production, how best to scale up PMLA microbial production and further functionalization for medicinal purposes? |
| cord-346446-i7gpxcyo | What are the potential applications of PMLA- based biopolymers other than as delivery platforms? |
| cord-346446-i7gpxcyo | What is the best way to uncover the genes that govern PMLA synthesis in relevant microorganisms such that they can be engineered in industrial bacteria or yeasts for large- scale PMLA bioproduction? |
| cord-346446-i7gpxcyo | What is the precise relationship between the molar mass of PMLA and its suitability as a delivery platform for cancer medicine? |
| cord-346446-i7gpxcyo | Why does the Abeta peptide of Alzheimer share structural similarity with antimicrobial peptides? |
| cord-346446-i7gpxcyo | nitrogen uptake and polymalic acid biosynthesis in polyextremotolerant fungus Aureobasidium pullulans Is beta- poly(L- malate) synthesis catalysed by a combination of beta- L- malyl- AMP- ligase and beta- poly(L- malate) polymerase? |
| cord-004534-jqm1hxps | -Single molecule biophysics- Is there a specific erythrocyte membrane receptor for fibrinogen? |
| cord-004534-jqm1hxps | A generalized quantitative FRAP method with no restriction on the size of the photobleached area Heterochromatin protein 1 in DNA damage response-recruitment or dissociation from repair sites? |
| cord-004534-jqm1hxps | Application of the methodology to binding of various aromatic drugs with DNA provides an answer to the question'What forces are the main contributors to the stabilization of aromatic ligand- DNA complexes'? |
| cord-004534-jqm1hxps | Do retinal rod outer segments carry out oxydative phosphorylation? |
| cord-004534-jqm1hxps | Does the lysosomal membrane need triglycerides? |
| cord-004534-jqm1hxps | What about the force? |
| cord-004534-jqm1hxps | pN. Pushing on microtubules: dominant spindle centering mechanism in C. elegans embryo? |
| cord-276456-oa6hh7ky | How can studies on membrane fission contribute to our understanding of membrane fusion? |
| cord-276456-oa6hh7ky | How does fusion peptide insertion lead to fusion of viruses to cell membranes? |
| cord-276456-oa6hh7ky | How does synaptotagmin trigger neurotransmitter release? |
| cord-276456-oa6hh7ky | Is the interior of the fusion pore protein or lipid? |
| cord-276456-oa6hh7ky | Is this effect specific for calcium over magnesium? |
| cord-276456-oa6hh7ky | Membrane Fusion? |
| cord-276456-oa6hh7ky | What exactly are SNARE proteins doing? |
| cord-276456-oa6hh7ky | What is the role of calcium once it enters? |
| cord-276456-oa6hh7ky | What role does the TMD play? |
| cord-276456-oa6hh7ky | Why Is PtdIns-4,5-P 2 Needed for Exocytotic Fusion? |
| cord-276456-oa6hh7ky | Why is PIP(2) needed for exocytosis? |
| cord-276456-oa6hh7ky | Why is synaptic release so fast? |
| cord-001835-0s7ok4uw | 3) Can an exhaustive statistical scan of a large, recent dataset identify new side chain interactions at helix termini? |
| cord-001835-0s7ok4uw | A Promoter or Inhibitor for IAPP aggregation? |
| cord-001835-0s7ok4uw | An empirical framework for binary interactome mapping Estimating the size of the human interactome Coming to peace with protein complexes? |
| cord-001835-0s7ok4uw | Are they essential in carrying out a specific cellular function? |
| cord-001835-0s7ok4uw | But the general effects on traits relevant at atomic/ residue resolutions have been less studied, and one fundamental issue remains unsolved: to what extent are proteins forced into interactions with highly concentrated solutes, and with what direct consequences? |
| cord-001835-0s7ok4uw | Can Bio- functionalities be deciphered from protein sequence information using computational approaches? |
| cord-001835-0s7ok4uw | Can site- directed mutagenesis shed light on the refolding pattern of human glucose 6-phosphate dehydrogenase( G6PD)? |
| cord-001835-0s7ok4uw | Can the structure of a protein( H3.1) depend on the treatment of a solvent medium( explicit vs effective) in a coarse- grained computer simulation? |
| cord-001835-0s7ok4uw | Do they play a regulatory role in controlling the on and off of a certain cellular process? |
| cord-001835-0s7ok4uw | How did enzymes, the catalysts of many crucial cellular processes, achieve this cold adaptation? |
| cord-001835-0s7ok4uw | In a protein engineering context, do we need to take into account the dynamics in order to maximize the fitness and function of the resulting proteins? |
| cord-001835-0s7ok4uw | Is there evolutionary pressure to conserve dynamics? |
| cord-001835-0s7ok4uw | Is this necessary to retain functionality, as it has been suggested? |
| cord-001835-0s7ok4uw | Protein engineering: what's next? |
| cord-001835-0s7ok4uw | Questions under- investigation includes what are the effects of mutations( e.g. b- and g- synuclein), how does the structure of an isolated ASN chain change in presence of many interacting protein chains, and how do they organize over the multiple length scales? |
| cord-001835-0s7ok4uw | To what extent are helix- terminal motifs that include multiple amino acids likely to represent genuine cooperative interactions between side chains, rather than chance alignments? |
| cord-001835-0s7ok4uw | Which particular helix- terminal loop geometries are favored by each side chain interaction? |
| cord-004584-bcw90f5b | ( Na? dependent)[ 4]. |
| cord-004584-bcw90f5b | / H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | 4000 lmol photons m-2 s-1) have shown that fast component of ms- DF was inhibited faster with time than in case of action of Co 2? and excess light. |
| cord-004584-bcw90f5b | 7, 1518 Budapest, HungaryWide- line proton NMR FID, echoes, spin- lattice and spin- spin relaxation times were measured at 82.55 MHz frequency in the-70 ° C to? |
| cord-004584-bcw90f5b | A putative outer- membrane cytochrome, OmcF, is crucial for Fe 3? |
| cord-004584-bcw90f5b | A recent candidate for pH regulation within early endosomes and TGN is the highly conserved intracellular Na? |
| cord-004584-bcw90f5b | Acyl transfer from lipids without enzyme catalysis: a new paradigm for membrane protein ageing? |
| cord-004584-bcw90f5b | Additional studies have shown that although neither the catalytic reaction nor the establishment of the DpH requires the presence of Na?, the presence of this ion increased the proton transport. |
| cord-004584-bcw90f5b | Analyzing the fluorescence relaxation kinetics,? |
| cord-004584-bcw90f5b | Ca 2? |
| cord-004584-bcw90f5b | Ca 2? and Mn 2?, that can be attributed to their sizes and coordination properties to specific ligands. |
| cord-004584-bcw90f5b | Ca 2? and Mn 2?, that can be attributed to their sizes and coordination properties to specific ligands. |
| cord-004584-bcw90f5b | Ca?? |
| cord-004584-bcw90f5b | Ca?? |
| cord-004584-bcw90f5b | Cell migration or proliferation? |
| cord-004584-bcw90f5b | ClpB is a hexameric AAA? |
| cord-004584-bcw90f5b | Combining all these results, a model for the coupling mechanism of complex I was proposed, suggesting the presence of two different energy coupling sites, one that works only as a proton pump( Na? independent), and the other functioning as a Na? |
| cord-004584-bcw90f5b | Combining all these results, a model for the coupling mechanism of complex I was proposed, suggesting the presence of two different energy coupling sites, one that works only as a proton pump( Na? independent), and the other functioning as a Na? |
| cord-004584-bcw90f5b | Compared to these channels, the voltage- dependence of TRPA1 is very weak( apparent number of gating charges* 0.4 versus 12 in K? channels) and its putative voltage- sensing domain most likely lies outside the S4 because TRPA1 completely lacks positively charged residues in this region. |
| cord-004584-bcw90f5b | Cytoplasmic dynein moves through uncoordinated action of the AAA1 ring domains Ahmet Yildiz Department of Physics, and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 USA Cytoplasmic dynein is a homodimeric AAA? |
| cord-004584-bcw90f5b | During action on chloroplasts only of Cd 2? |
| cord-004584-bcw90f5b | Forward and reverse transport directions were investigated at zero membrane potential using preparations with inside out and right side out oriented transporters with Na? or H? |
| cord-004584-bcw90f5b | Furthermore, Na? |
| cord-004584-bcw90f5b | Generalized epilepsy with febrile seizures plus( GEFS?, OMIM 604233) is a childhood genetic epilepsy syndrome correlated to mutations in the ancillary b- subunit of neuronal voltage- gated sodium channels( NaChs). |
| cord-004584-bcw90f5b | I reduce ubiquinone, it is suggested that the Na?/H? |
| cord-004584-bcw90f5b | I reduce ubiquinone, it is suggested that the Na?/H? |
| cord-004584-bcw90f5b | In addition, our systematic and quantitative analysis( in combination with genetic modifications) provides a tool to study the role of? |
| cord-004584-bcw90f5b | In both strains the pH dependence was associated with a systematic increase of the K m for Na? |
| cord-004584-bcw90f5b | In the photosynthetic reaction center( RC) of Rhodobacter sphaeroides, fast formation of the charge separated state P? |
| cord-004584-bcw90f5b | In the present work, Al 3? induced conformational change and instant oligomerization of aS have been studied using FRET and FCS as main techniques. |
| cord-004584-bcw90f5b | In the shorter(\ 1 ms) time scale, the dominating effect is the re- reduction of the oxidized primary donor( P?? |
| cord-004584-bcw90f5b | In the shorter(\ 1 ms) time scale, the dominating effect is the re- reduction of the oxidized primary donor( P?? |
| cord-004584-bcw90f5b | Initial expression levels were determined by either partial purification using Ni 2?-NTA |
| cord-004584-bcw90f5b | It was observed that the Na? |
| cord-004584-bcw90f5b | It was observed that this bacterial complex I is able of H? |
| cord-004584-bcw90f5b | K? |
| cord-004584-bcw90f5b | Nigericin, a peptide that acts as an H?-K? |
| cord-004584-bcw90f5b | Nigericin, a peptide that acts as an H?-K? |
| cord-004584-bcw90f5b | Result indicates that damage sites of action Cd 2? |
| cord-004584-bcw90f5b | Simultaneous action of Cd 2? and photoinhibitory illumination( |
| cord-004584-bcw90f5b | Taken together with our results on the subcellular localization of the native NHE7, these unique biochemical features provide new insights on the biological function and pathological implications of this intracellular Na? |
| cord-004584-bcw90f5b | The aim of these studies was to clarify whether the specific crystalline structure of protein and protein- substrate interactions are significant for H? |
| cord-004584-bcw90f5b | The available data are restricted and only the re- oxidation of the reduced primary quinone( Q A-? |
| cord-004584-bcw90f5b | The average lifetime of donor in the presence of acceptor increases with the increase of Al 3? |
| cord-004584-bcw90f5b | The coupling ion of the system was shown to be the H? |
| cord-004584-bcw90f5b | The first and best characterized GEFS? |
| cord-004584-bcw90f5b | The intrinsic Tyr fluorescence rises sharply within the mixing dead time, reflecting an enhanced hydrophobicity of the Tyr environment and a fast conformational change of aS. Al 3? |
| cord-004584-bcw90f5b | The simultaneous effect of photoinhibitory illumination and toxic action of heavy metals ions( Cd 2? |
| cord-004584-bcw90f5b | The steadystate level at Cd 2? |
| cord-004584-bcw90f5b | The transmembrane part of the tetrameric TRPA1 is structurally related to the voltagegated K? channels in which the conserved charged residues within the fourth transmembrane region( S4) constitute part of a voltage sensor. |
| cord-004584-bcw90f5b | These data allowed to advance a transport mechanism based on competing Na? |
| cord-004584-bcw90f5b | This inner structure transmits local signals due to ATP binding and hydrolysis by AAA? domains. |
| cord-004584-bcw90f5b | This model was reinforced by further studies performed in the presence of the Na? |
| cord-004584-bcw90f5b | This work was supported by the Italian Association for Cancer Research( AIRC), the Istituto Toscano Tumori and the Associazione Noi per Voi Differential hydration, void volume: which factor provides the main contribution to DV u? |
| cord-004584-bcw90f5b | Thus, notable variations in the RNA binding specificity was observed for the divalent ions of Mg 2? |
| cord-004584-bcw90f5b | Under symmetrical Na? |
| cord-004584-bcw90f5b | Under symmetrical pH conditions with a Na? |
| cord-004584-bcw90f5b | We assume that binding site of Cd 2? is Y Z or CaMn 4-cluster, one of the recombination partners with P 680? |
| cord-004584-bcw90f5b | We assume that binding site of Cd 2? is Y Z or CaMn 4-cluster, one of the recombination partners with P 680? |
| cord-004584-bcw90f5b | We have developed somatic cell genetic techniques that enable the selection of variant cells able to resist H? |
| cord-004584-bcw90f5b | We reported previously that the increase of the cholesterol content of the cell membrane( in vitro) modified the biophysical parameters of the gating of Kvl.3 K? ion channels in human T- lymphocytes. |
| cord-004584-bcw90f5b | What makes an amyloid toxic: morphology, structure or interaction with membranes? |
| cord-004584-bcw90f5b | Whole- cell K? |
| cord-004584-bcw90f5b | and Co 2? are donor and acceptor side of PS2, accordingly. |
| cord-004584-bcw90f5b | and Co 2?) |
| cord-004584-bcw90f5b | and H? |
| cord-004584-bcw90f5b | and Na? |
| cord-004584-bcw90f5b | and U 6? reduction and also for microbial electricity production( 4). |
| cord-004584-bcw90f5b | being transported to the periplasm, contributing in this way to the establishment of the electrochemical potential difference, while Na? is translocated to the cytoplasm[ 4]. |
| cord-004584-bcw90f5b | both alkaline pH and Na? |
| cord-004584-bcw90f5b | by extracellular Ca 2? entry probably through mechanosensitive channels. |
| cord-004584-bcw90f5b | concentration, indicating aS adopts a more extended conformation upon Al 3? |
| cord-004584-bcw90f5b | hERG K? channels is associated with increased risk of arrhythmias. |
| cord-004584-bcw90f5b | killing through plasma membrane expression of H? extruders. |
| cord-004584-bcw90f5b | the fast component of ms- DF, which originates via radiative recombination of reaction center with the CaMn 4-cluster or Y Z on donor side of PS2, is inhibited stronger than at action of only Co 2?. |
| cord-004584-bcw90f5b | treatment is remain stable, while at Co 2? |