bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
membrane fusion	527
plasma membrane	508
amino acid	361
membrane proteins	353
amino acids	308
influenza virus	286
host cell	272
cell membrane	261
lipid bilayer	248
cell surface	218
molecular dynamics	204
antimicrobial peptides	193
membrane protein	192
lipid bilayers	191
fusion proteins	187
lipid rafts	182
fusion peptide	180
endoplasmic reticulum	176
membrane oxygenation	173
conformational changes	172
extracorporeal membrane	172
nfn membranes	171
golgi apparatus	158
virus particles	147
membrane vesicles	142
free energy	141
enveloped viruses	140
infected cells	134
electron microscopy	131
fusion protein	130
cell membranes	130
binding site	128
lipid membranes	121
outer membrane	119
virus replication	119
living cells	119
semliki forest	118
epithelial cells	116
acute respiratory	115
forest virus	114
negatively charged	113
protein interactions	113
rna replication	112
fusion peptides	112
viral rna	110
conformational change	109
respiratory syndrome	109
secondary structure	106
crystal structure	105
low ph	105
severe acute	100
active site	100
cytoplasmic domain	99
virus entry	97
model membranes	97
dynamics simulations	97
acid residues	95
mass spectrometry	95
class i	94
viral fusion	94
class ii	94
type i	93
rna synthesis	92
single molecule	91
drug delivery	90
replication complex	89
pore formation	88
protein structure	88
vesicular stomatitis	88
membrane surface	88
secretory pathway	87
molecular weight	87
membrane curvature	85
wild type	84
surface area	84
circular dichroism	84
viral membrane	84
important role	83
mammalian cells	82
escherichia coli	82
lipid composition	81
light scattering	80
stomatitis virus	79
integral membrane	79
binding sites	78
viral proteins	78
antimicrobial peptide	76
protein folding	76
results show	76
membrane insertion	75
cell culture	75
antimicrobial activity	75
cell fusion	74
ion channels	74
atomic force	73
biological membranes	72
fluorescence microscopy	72
gene therapy	72
viral glycoproteins	71
two different	71
fusion activity	71
syndrome coronavirus	71
rna viruses	70
viral replication	69
acidic ph	69
membrane rearrangements	69
transmembrane domain	68
cord uid	68
doc id	68
binding protein	67
cell types	67
terminal domain	67
golgi complex	67
sialic acid	67
viral entry	66
force microscopy	66
cell lines	66
results suggest	66
dengue virus	65
membrane binding	65
fatty acids	65
live cells	64
lipid membrane	64
wide range	64
signal transduction	63
crystal structures	63
host cells	63
virus type	62
immune responses	62
intrinsically disordered	62
cellular membranes	62
key role	62
energy transfer	61
protein complexes	61
signal sequence	61
target membrane	61
fusion loop	60
signal peptidase	60
viral envelope	59
molecular mechanisms	59
acid sequence	59
amyloid fibrils	59
fluorescence spectroscopy	59
mechanical properties	58
commonly used	58
ligand binding	57
phase separation	57
fatty acid	57
gap junctions	57
ionic strength	57
fluorescent protein	57
spike protein	56
cell wall	56
side chain	56
highly conserved	56
model system	56
immune cells	56
envelope protein	56
may also	56
influenza hemagglutinin	55
widely used	55
immunodeficiency virus	55
induced membrane	55
binding proteins	55
ion channel	55
nucleic acids	55
structural changes	55
membrane domains	54
virus infection	54
cancer cells	54
hydrogen bonds	54
experimental data	54
water interface	53
cell line	53
herpes simplex	53
molecular level	53
fusion pore	53
results indicate	53
water molecules	52
positively charged	52
also observed	52
recent studies	52
spherical particles	52
cell adhesion	52
side chains	52
nervous system	51
cell biology	51
dependent manner	51
supported lipid	51
sars fp	51
electrospun nanofibers	51
growth factor	51
strand rna	51
breast cancer	51
head group	50
membrane permeability	50
endocytic pathway	50
correlation spectroscopy	50
immune response	50
quantum dots	50
molecular biology	49
viral infection	49
mediated endocytosis	49
golgl apparatus	49
takes place	49
human immunodeficiency	48
sindbis virus	48
signal peptide	48
receptor binding	48
inner membrane	48
replication complexes	48
negative bacteria	48
simplex virus	48
fusion process	48
cell death	48
life support	48
nmr spectroscopy	47
membrane interactions	47
model membrane	47
cellular processes	47
molecular mechanism	47
virus hemagglutinin	46
binding domain	46
membrane lipids	46
type atpases	46
electrostatic interactions	46
mdck cells	46
lipid raft	46
intracellular transport	46
transmembrane proteins	46
different types	46
ii fusion	46
extracorporeal life	45
confocal microscopy	45
cleavage site	45
membrane lipid	45
titration calorimetry	44
also found	43
encephalitis virus	43
cells infected	43
gene expression	43
virus membrane	43
isothermal titration	43
data suggest	43
membrane association	42
transmembrane protein	42
electron transfer	42
ray scattering	42
previous studies	42
sendai virus	42
recent years	42
aromatic residues	42
terminal region	41
membrane structures	41
respiratory failure	41
charged residues	41
gene product	41
saccharomyces cerevisiae	41
complex formation	41
polarized epithelial	41
sars ifp	41
outer leaflet	41
first time	41
first step	41
type ii	40
i will	40
stranded rna	40
hepatitis virus	40
ellipsoidal particles	40
high affinity	40
even though	40
pore size	40
innate immune	40
small molecules	40
fluorescence correlation	40
carbon nanotubes	40
sars coronavirus	40
snare complex	40
hydrophobic segment	40
virus assembly	40
fluorescent proteins	39
eukaryotic cells	39
phase transition	39
binding mode	39
small molecule	39
proteins involved	39
electric field	39
lipid vesicles	39
immune system	39
unilamellar vesicles	39
membrane interaction	39
like particles	39
hydrophobic amino	39
biological systems	38
also known	38
single virion	38
plasma membranes	38
fusion loops	38
room temperature	38
structural proteins	37
large number	37
virus fusion	37
allowed us	37
oxidative stress	37
line tension	37
take place	37
virus envelope	37
protein complex	37
membrane structure	37
tumor cells	37
particle diameter	37
live cell	37
hydrophobic core	36
gap junction	36
mg ml	36
membrane rafts	36
md simulations	36
membrane potential	36
leu leu	36
red blood	36
binding affinity	36
target cell	36
lipid mixing	36
results obtained	36
envelope glycoprotein	36
flow rate	36
molecular interactions	35
physiological conditions	35
atpase activity	35
actin cytoskeleton	35
membranotropic peptides	35
mouse hepatitis	35
acyl chain	35
ganglioside gm	35
dynamic light	35
enzyme activity	35
virus glycoprotein	35
cellular functions	35
cells expressing	35
neutral ph	34
dendritic cells	34
tertiary structure	34
coronavirus spike	34
protein aggregation	34
present study	34
physical properties	34
like structures	34
filter cake	34
directed mutagenesis	34
rna virus	34
endothelial cells	34
palmitoylated proteins	34
er membrane	34
tm domain	34
ray crystallography	34
stem cells	34
life cycle	34
membrane tension	33
proteolytic cleavage	33
hydrophobic residues	33
extracellular matrix	33
active transport	33
target cells	33
i fusion	33
high resolution	33
coronavirus replication	33
vesicle formation	33
rna polymerase	33
resonance energy	33
env gene	33
present work	33
magnetic resonance	33
contact angle	33
cell division	33
newly synthesized	33
dimensional structure	33
leukemia virus	33
cell type	33
cell entry	33
serum albumin	32
catalytic domain	32
nonstructural protein	32
differential scanning	32
click chemistry	32
electron microscope	32
two types	32
transcription factor	32
surface plasmon	32
high concentrations	32
two distinct	32
permeate flux	31
gel electrophoresis	31
different cell	31
structural biology	31
protein kinase	31
electrospun fibers	31
van der	31
cultured cells	31
domain ii	31
sialic acids	31
physicochemical properties	31
influenza viruses	31
will present	31
activator protein	31
recent study	31
snare proteins	31
malic acid	31
protein dynamics	31
cell cycle	31
transmembrane domains	30
fluid phase	30
structural studies	30
form i	30
double membrane	30
coated vesicles	30
cell plasma	30
wide variety	30
membrane adsorbers	30
water vapor	30
fine particles	30
transcription factors	30
antibacterial activity	30
channel activity	30
head groups	30
associated protein	30
protein synthesis	30
protein interaction	30
bilayer membranes	30
apical membrane	30
naturally occurring	30
fluorescence intensity	30
enzymatic activity	30
fluid interfaces	30
better understanding	30
hydrophobic interactions	30
host membrane	30
palmitic acid	30
lipid interactions	29
biological effects	29
anchored proteins	29
cellular membrane	29
structural features	29
poorly understood	29
intracellular delivery	29
particle size	29
membrane transport	29
membrane microdomains	29
protein binding	29
neutron scattering	29
plasmon resonance	29
virus particle	29
biological processes	29
synaptic vesicle	29
molecule fluorescence	29
size distribution	29
metal ions	29
sorting signals	29
taken together	29
diffusion coefficient	29
protein palmitoylation	29
structural information	29
epithelial cell	29
intracellular membranes	29
acidic residues	28
membranes containing	28
signaling pathways	28
affinity chromatography	28
ebola virus	28
surface charge	28
positive bacteria	28
target membranes	28
exclusion chromatography	28
ml min	28
cell activation	28
aqueous solution	28
acyl chains	28
structural basis	28
fusion mechanism	28
helical structure	28
infectious bronchitis	28
previously described	28
viral genome	28
gold particles	28
side effects	28
synthetic peptides	28
late endosomes	28
membrane filtration	28
animal cells	28
bacterial cell	28
surface tension	28
gene delivery	27
mitochondrial membrane	27
well known	27
bronchitis virus	27
virion tracking	27
neurodegenerative diseases	27
small angle	27
helix bundle	27
brain barrier	27
molecular basis	27
monoclonal antibodies	27
fhv rna	27
model systems	27
crucial role	27
fluorescence lifetime	27
antiviral activity	27
structural analysis	27
outer mitochondrial	27
vaccinia virus	27
full length	27
fibril formation	27
two proteins	27
aspect ratio	27
quartz crystal	26
hela cells	26
cytoplasmic tail	26
reactive oxygen	26
mediated membrane	26
patients receiving	26
amino terminus	26
electron tomography	26
clinical trials	26
outer membranes	26
terminal residues	26
central nervous	26
fiber diameter	26
er membranes	26
membrane permeabilization	26
phospholipid bilayer	26
mass transfer	26
induce membrane	26
driving force	26
energy barrier	26
bovine serum	26
viral glycoprotein	26
nonstructural proteins	26
may provide	26
thermal stability	26
nuclear magnetic	26
oxygen species	26
molar ratio	26
fibrous membranes	26
cell imaging	26
nucleic acid	26
substrate specificity	26
size exclusion	26
gel phase	25
results provide	25
peptides derived	25
coiled coil	25
membrane bilayer	25
photosystem ii	25
inhibitory effect	25
structure prediction	25
protein structures	25
blood cells	25
viral vectors	25
inner leaflet	25
essential role	25
monoclonal antibody	25
remains unclear	25
cytoplasmic membrane	25
base pairs	25
amyloid formation	25
bacterial membrane	25
ph dependence	25
dna damage	25
interface deformations	25
isoelectric point	25
culture medium	25
cholera toxin	25
high concentration	25
nm diameter	25
two membranes	25
west nile	25
golgi network	24
lipid domains	24
terminal segment	24
venovenous extracorporeal	24
crystal microbalance	24
paired membranes	24
biological activity	24
disulfide bonds	24
proteins may	24
binding pocket	24
atomic resolution	24
drug discovery	24
membrane interface	24
multidrug resistance	24
green fluorescent	24
well understood	24
lipid metabolism	24
physical chemistry	24
borne encephalitis	24
close proximity	24
biologically active	24
murine leukemia	24
translocation across	24
protein function	24
biological function	24
least one	24
data obtained	24
envelope proteins	24
ph values	24
scanning calorimetry	24
fourier transform	24
protein sorting	24
native state	24
transmission electron	24
immune cell	23
peptidase cleavage	23
esn process	23
polypeptide chain	23
giant unilamellar	23
delivery systems	23
potassium channel	23
per cell	23
viral protein	23
mosaic virus	23
structural properties	23
kidney cells	23
df cells	23
genomic rna	23
electrospun nanofiber	23
allows us	23
transmembrane helices	23
biological membrane	23
ray diffraction	23
particle tracking	23
synthetic peptide	23
membrane area	23
proton transfer	23
hydrogen bonding	23
new insights	23
atp hydrolysis	23
structural characterization	23
cells using	23
disordered proteins	23
domain formation	23
bond formation	23
two major	23
laser scanning	23
transmembrane anchor	23
computational methods	23
viral particles	23
cytoplasmic side	23
cancer cell	23
ganglioside biosynthesis	23
early endosomes	23
protein transport	22
dipartimento di	22
aspartic acid	22
therapy vectors	22
using fluorescence	22
type iii	22
recent work	22
closely related	22
dmv formation	22
average diameter	22
protein aggregates	22
stem cell	22
lumenal domain	22
cytoplasmic domains	22
coverage rate	22
virus proteins	22
hydrogen bond	22
sarcoma virus	22
replicase proteins	22
tyrosine kinase	22
metal ion	22
mammalian cell	22
state nmr	22
nanofibrous membranes	22
real time	22
disulfide bond	22
charged amino	22
low concentrations	22
direct interaction	22
energy landscape	22
hyaluronic acid	22
virus glycoproteins	22
blood cell	22
proton pump	22
enveloped virus	22
sorting signal	22
like receptor	22
form ii	22
cell proliferation	22
polymer solution	22
heparan sulfate	22
two main	22
human diseases	22
skeletal muscle	22
studied using	22
will also	22
vv ecls	22
drug design	22
single particle	22
chain length	22
virus rna	22
direct role	21
mediated interactions	21
great potential	21
membrane alterations	21
binding domains	21
passive diffusion	21
protein stability	21
fluorescent probes	21
spike glycoprotein	21
phase diagram	21
performed using	21
unfolded state	21
hydration water	21
charged lipids	21
venovenous ecmo	21
endocytic pathways	21
infected cell	21
nucleotide binding	21
force spectroscopy	21
rational design	21
results demonstrate	21
binding modes	21
kinetic parameters	21
vesicular transport	21
three different	21
active packaging	21
planar lipid	21
acid sequences	21
penetrating peptides	21
electrochemical gradient	21
intracellular trafficking	21
polymalic acid	21
domain iii	21
composite nfn	21
aspect ratios	21
functional groups	21
results showed	21
confocal laser	21
experimental results	21
hollow fiber	21
replication sites	21
replication factories	21
host proteins	21
sieving coefficient	21
peptide binding	21
staphylococcus aureus	21
gm activator	20
transfection efficiency	20
tissue engineering	20
data show	20
also used	20
basolateral membrane	20
infectious diseases	20
lipid packing	20
human body	20
titanium dioxide	20
may play	20
electron spin	20
peptide derived	20
raman spectroscopy	20
capillary interactions	20
drug resistance	20
epidermal growth	20
reaction center	20
key step	20
currently used	20
optical tweezers	20
binding kinetics	20
state university	20
plasmid dna	20
cellular uptake	20
better understand	20
basolateral sorting	20
binding properties	20
spontaneous curvature	20
stapled peptides	20
primary structure	20
drug development	20
peptide bond	20
experiments showed	20
may contribute	20
scanning electron	20
molecule level	20
force field	20
subcellular localization	20
recent advances	20
translational modifications	20
actin filaments	20
helical conformation	20
signaling pathway	20
fluorescently labeled	20
membrane systems	20
associated proteins	20
survival rate	20
signal sequences	20
concentration gradient	20
functional role	20
temperature dependence	20
long time	20
functional characterization	20
terminal amino	20
shed light	20
critical role	19
human genome	19
abc transporters	19
will allow	19
electrospinning process	19
investigated using	19
protein engineering	19
fully understood	19
simian virus	19
fusion reaction	19
envelope fusion	19
may lead	19
electrostatic forces	19
secretory proteins	19
liquid membrane	19
sequence similarity	19
may occur	19
membrane components	19
net charge	19
many different	19
cholesterol depletion	19
life sciences	19
good agreement	19
membrane trafficking	19
organic solvents	19
lipid molecules	19
allow us	19
infrared spectroscopy	19
early stages	19
catalytic activity	19
flock house	19
human disease	19
muscle cells	19
optical microscopy	19
using nmr	19
delivery system	19
glucose transporter	19
cardiogenic shock	19
table i	19
phospholipid bilayers	19
structural protein	19
atp binding	19
biophysical chemistry	19
water molecule	19
chemical properties	19
cellular components	19
substrate binding	19
sodium channel	19
cell viability	19
amyloid aggregation	19
house virus	19
electrostatic interaction	19
monte carlo	19
experimental studies	19
terminal sequence	19
dissociation constant	19
temporal resolution	18
provide new	18
high pressure	18
described previously	18
two domains	18
recombinant proteins	18
adhesion strength	18
biochemical characterization	18
fusion events	18
membrane dynamics	18
membrane invaginations	18
protein unfolding	18
cov fp	18
gas exchange	18
carcinogenic cells	18
large scale	18
hydrophobic domain	18
human health	18
golgi membrane	18
unpublished data	18
early stage	18
much larger	18
studies using	18
gene encoding	18
potassium channels	18
fluorescence quenching	18
inhibitory activity	18
biomedical applications	18
quantitative analysis	18
structural data	18
experimental evidence	18
facilitated diffusion	18
chemical synthesis	18
like protein	18
time scale	18
transition temperature	18
detergent micelles	18
single cell	18
previous work	18
deletion mutants	18
istituto di	18
rich domains	18
cysteine residues	18
membrane composition	18
protein degradation	18
highly sensitive	18
transmembrane region	18
epithelial polarity	18
nuclear membrane	18
powerful tool	18
sized particles	18
also show	18
covalently linked	18
kj mol	18
viral particle	18
signi cant	18
applied voltage	18
polar head	18
last years	18
phospholipid membranes	18
middle east	18
blood flow	18
receiving venovenous	18
erythrocyte membrane	18
rubella virus	18
will show	18
membrane targeting	18
selectivity filter	18
transform infrared	18
polyethylene glycol	18
membranous replication	18
schiff base	18
bacterial membranes	18
different stages	18
contact line	18
bacterial cells	18
time resolved	17
order parameter	17
graduate school	17
electron transport	17
point mutations	17
surface expression	17
critical care	17
ion transport	17
adaptor proteins	17
bending rigidity	17
limiting step	17
polarized cells	17
type protein	17
protein translocation	17
rate limiting	17
peptide synthesis	17
kcal mol	17
complex i	17
high degree	17
protein sequences	17
metal binding	17
different membrane	17
disease virus	17
membrane anchor	17
der waals	17
specific surface	17
still unclear	17
envelope glycoproteins	17
east respiratory	17
taking advantage	17
specific proteins	17
measured using	17
least two	17
catalytic efficiency	17
wrapped states	17
optical properties	17
flow cytometry	17
binding partners	17
membrane fouling	17
high porosity	17
membrane vesicle	17
influenza ha	17
may cause	17
membrane fluidity	17
dna binding	17
electrostatic repulsion	17
time resolution	17
different proteins	17
significantly higher	17
energy barriers	17
brush border	17
cell migration	17
using different	17
primary sequence	17
recently developed	17
replication cycle	17
induced conformational	17
new class	17
will provide	17
spherical particle	17
fatty acyl	17
scanning microscopy	17
cell walls	17
stranded dna	17
temperature range	17
experimental conditions	17
biological interfaces	17
functional properties	17
domain size	17
vero cells	17
lateral diffusion	17
medical applications	17
important roles	17
gene transfer	17
lipid head	17
drosophila cells	17
serine protease	17
fluorescence anisotropy	17
tyrosine kinases	17
also shown	17
cellular proteins	16
actin polymerization	16
transport vesicles	16
specific binding	16
esn nfn	16
cell receptor	16
proximal tubule	16
peptide concentration	16
plant cells	16
protein domains	16
virulence factors	16
wound healing	16
spin label	16
japanese encephalitis	16
membrane organization	16
studies showed	16
sorting machinery	16
dmv interior	16
many cases	16
chemical society	16
human cells	16
ex vivo	16
cov infection	16
rate constant	16
american chemical	16
high levels	16
striated muscle	16
phase transitions	16
physiological functions	16
vacuolar membrane	16
previously reported	16
like structure	16
structural dynamics	16
protein molecules	16
virus budding	16
magnetic field	16
major role	16
active sites	16
hydrophobic region	16
formic acid	16
animal viruses	16
osmotic pressure	16
gated ion	16
polypeptide chains	16
preliminary results	16
two membrane	16
drug candidates	16
adhesion energy	16
starting point	16
hydrophobic interaction	16
elastic properties	16
na ions	16
distress syndrome	16
present results	16
molecular weights	16
high level	16
amphipathic helix	16
phase behavior	16
chemical shift	16
also play	16
kda antigen	16
neurotransmitter release	16
dna sequence	16
thylakoid membranes	16
biophysical techniques	16
will discuss	16
aggregation process	16
chemical reaction	16
rsv env	16
factor receptor	16
gm gangliosidosis	16
secondary structures	16
specific protein	16
membrane bioreactor	16
gene products	16
content mixing	16
thin film	16
across membranes	16
dynamics simulation	16
also showed	16
surface receptor	16
like proteins	16
influenza virions	16
atom molecular	16
single protein	16
steady state	16
nile virus	16
air stream	16
biophysical properties	16
low temperature	16
membrane compartments	16
public health	16
respiratory distress	16
least three	16
divalent cations	16
membrane glycoprotein	16
expressing nsp	16
central role	16
negative curvature	16
membrane deformation	16
cell surfaces	15
phosphate buffer	15
virtual screening	15
analytical ultracentrifugation	15
broad range	15
electron microscopic	15
target protein	15
protein expression	15
resolved fluorescence	15
polymer solutions	15
protein design	15
lipid compositions	15
ph range	15
giving rise	15
native structure	15
successfully used	15
cleavage sites	15
rat brain	15
pore sizes	15
novel approach	15
particle surface	15
erythrocyte membranes	15
tilt series	15
folding process	15
high molecular	15
hemolytic activity	15
cysteine residue	15
phosphate group	15
membrane pairing	15
replacement therapy	15
acid composition	15
single molecules	15
high efficiency	15
heat shock	15
membrane topology	15
sachs disease	15
random coil	15
synaptic vesicles	15
rate constants	15
water purification	15
neuronal cells	15
phage display	15
membrane cholesterol	15
surface properties	15
autophagic vacuoles	15
health effects	15
financial support	15
cationic antimicrobial	15
inflammatory responses	15
lysosomal storage	15
soluble proteins	15
small size	15
di fisica	15
different lipid	15
molecular details	15
high surface	15
like nano	15
low concentration	15
vesicle fusion	15
independent endocytosis	15
bacterial infections	15
ab initio	15
atomic level	15
analysis showed	15
nucleotide sequence	15
muscle contraction	15
approach based	15
internal reflection	15
pathogenic bacteria	15
nmr studies	15
cholesterol content	15
virus nonstructural	15
dmv inner	15
transferrin receptor	15
rearrangements induced	15
conformational states	15
fluorescence emission	15
contact angles	15
production processes	15
virus factories	15
domain i	15
college london	15
induces membrane	15
still unknown	15
sheet structure	15
spatial resolution	15
one side	15
coated pits	15
high throughput	15
human brain	15
storage diseases	15
patch clamp	15
von heijne	15
potential applications	15
terminal half	15
one cell	15
spin resonance	15
terminal end	15
carbonic anhydrase	15
secretory vesicles	15
nsp alone	15
ftir spectroscopy	15
different protein	15
using molecular	15
total internal	15
thermal unfolding	15
reticulovesicular network	15
protein may	15
binding strength	14
electron paramagnetic	14
arterivirus replication	14
replicase subunits	14
precursor protein	14
sequence homology	14
adult patients	14
outer surface	14
avian sarcoma	14
coronavirus replicase	14
molecular motors	14
experiments show	14
ion exchange	14
conformational transition	14
light chain	14
evidence suggests	14
peripheral membrane	14
working environment	14
building blocks	14
may facilitate	14
charged lipid	14
low energy	14
pseudomonas aeruginosa	14
therapeutic potential	14
cancer therapy	14
basolateral targeting	14
health organization	14
beaur nsp	14
world health	14
new method	14
peptide sequences	14
using two	14
thromboembolic events	14
cytoplasmic face	14
virus groups	14
rous sarcoma	14
excited state	14
formation mechanism	14
composite membranes	14
direct contact	14
nuclear envelope	14
molecular docking	14
many studies	14
dead cells	14
extracellular vesicles	14
expression vector	14
structure determination	14
among others	14
protein kinases	14
via electrospinning	14
lipid peroxidation	14
partition coefficient	14
mm tris	14
humic substances	14
comparative study	14
charged phospholipids	14
fatty acylation	14
thermodynamic parameters	14
trp residues	14
acylated proteins	14
fold higher	14
calcium binding	14
microscopy techniques	14
quaternary structure	14
mechanical strength	14
coding region	14
binding cassette	14
lipid phase	14
cov fusion	14
pure water	14
membrane disruption	14
membrane remodeling	14
coronavirus envelope	14
transition state	14
soluble protein	14
charge density	14
specific antibodies	14
membrane penetration	14
membrane active	14
brain gangliosides	14
sodium channels	14
canine kidney	14
particle concentration	14
fusion domain	14
golgi membranes	14
acid residue	14
absorption spectroscopy	14
tryptophan residues	14
bacillus subtilis	14
using single	14
downstream processing	14
coat proteins	14
aqueous solutions	14
bound state	14
bound form	14
biophysical characterization	14
ion binding	14
host immune	14
solution structure	14
cell signaling	14
solid phase	14
indirect immunofluorescence	14
flow filtration	14
functional domains	14
listeria monocytogenes	14
similar results	14
cd spectroscopy	14
research center	14
basolateral surface	14
italian institute	14
large unilamellar	14
molecular recognition	14
intracellular membrane	14
higher affinity	14
binding process	14
wnv kun	14
planck institute	14
per unit	14
see chapter	14
nmr structure	14
imaging techniques	14
protein surface	14
open reading	14
gives rise	14
tangential flow	14
action potentials	14
much less	14
manuscript submitted	14
ray structure	14
also studied	14
results will	14
surface modification	14
early endosome	14
polyacrylamide gel	14
western blot	14
extensively studied	14
tirf microscopy	14
proteomic analysis	14
adaptor protein	14
golgi transport	14
anionic lipids	14
entry process	14
cell functions	14
induced fusion	14
membrane receptors	14
gas phase	14
external force	14
organic compounds	14
molecular modeling	14
computer simulation	14
one another	13
membrane modifications	13
protein conformation	13
structural motif	13
peptide sequence	13
virus protein	13
cell lysis	13
changes induced	13
spanning region	13
licl solution	13
best studied	13
living cell	13
may result	13
virus maturation	13
uranyl acetate	13
cardiopulmonary resuscitation	13
charged droplets	13
lactic acid	13
action potential	13
respiratory syncytial	13
role played	13
conformational state	13
wastewater treatment	13
repeat proteins	13
national institute	13
aromatic amino	13
physiological ph	13
dna sequences	13
biological functions	13
lysosomal membrane	13
highly specific	13
mitochondrial membranes	13
syncytial virus	13
oxygenation support	13
electron density	13
transmembrane helix	13
inner membranes	13
mhc class	13
scale bars	13
tissue culture	13
structural similarity	13
previously shown	13
fluorescence resonance	13
several studies	13
conformational transitions	13
point mutation	13
support organization	13
dimensional structures	13
see materials	13
coupled receptors	13
melting temperature	13
may help	13
transport properties	13
disordered regions	13
bioactive peptides	13
viral surface	13
bsa molecules	13
new insight	13
membrane anchoring	13
novel coronavirus	13
host cellular	13
thin films	13
bone marrow	13
pore radius	13
contains two	13
sequence analysis	13
endocytic process	13
rabies virus	13
fibrillar aggregates	13
high sensitivity	13
cell growth	13
give rise	13
antibiotic resistance	13
fluorescent molecules	13
recent data	13
protein concentration	13
success rate	13
tryptophan fluorescence	13
structural components	13
unit operations	13
membrane associated	13
studies revealed	13
carbon dioxide	13
well established	13
carboxylic acid	13
bending energy	13
respiratory tract	13
cho cells	13
widely accepted	13
protease inhibitor	13
glutamic acid	13
proteins using	13
solid surfaces	13
host defense	13
will focus	13
signalling pathways	13
three main	13
sem images	13
charged droplet	13
much higher	13
carboxy terminus	13
explicit solvent	13
morphological changes	13
synchrotron radiation	13
membrane properties	13
spectroscopic techniques	13
distinct membrane	13
fluorescence techniques	13
associated virus	13
fluorescence microscope	13
recently reported	13
endosomal ph	13
cystic fibrosis	13
higher plants	13
coat protein	13
inner vesicles	13
janus particles	13
electrospun nanofibrous	13
operating conditions	13
hinge region	13
viral membranes	13
purification process	13
scale bar	13
hydrophobic regions	13
collagen gel	13
three times	13
hairpin structure	13
lifetime imaging	13
enabled us	13
different mechanisms	13
yeast cells	13
different ph	13
paramagnetic resonance	13
dust explosion	13
total number	13
resolution structure	13
mediated fusion	13
water treatment	13
nanofibrous membrane	13
spin labels	13
solid supported	13
series gangliosides	13
receptor tyrosine	13
protein association	13
free energies	12
protein assembly	12
packing density	12
protease activity	12
form amyloid	12
signal recognition	12
provide evidence	12
mutant protein	12
secretory protein	12
cylindrical particles	12
peptides corresponding	12
data bank	12
normal cells	12
surface receptors	12
membrane interfaces	12
genetic engineering	12
extensively used	12
occurs via	12
coated pit	12
virus attachment	12
i viral	12
great interest	12
specific interactions	12
pc jr	12
cell cytoplasm	12
mouse models	12
kinetic analysis	12
therapeutic strategies	12
three dimensional	12
motor proteins	12
photosynthetic apparatus	12
low levels	12
membrane dehydration	12
conformational flexibility	12
murine coronavirus	12
likely due	12
wrapped state	12
membrane glycoproteins	12
dna repair	12
secreted proteins	12
terminal domains	12
membrane via	12
brownian diffusion	12
virus surface	12
colloidal particles	12
biological cells	12
immunological synapse	12
simple model	12
targeting signal	12
one type	12
ca binding	12
gated sodium	12
coated vesicle	12
darby canine	12
size range	12
results reveal	12
conserved cysteine	12
directly involved	12
antimicrobial agents	12
biologically relevant	12
may represent	12
water permeability	12
per se	12
extremely small	12
four different	12
ef ciency	12
important factor	12
max planck	12
helical segment	12
stapled peptide	12
hiv gp	12
modified endoplasmic	12
membrane destabilization	12
highly curved	12
relatively high	12
provide insights	12
containing membranes	12
adaptive immune	12
apparent affinity	12
peripheral proteins	12
motor protein	12
adhesion strengths	12
recent research	12
significantly reduced	12
electric fields	12
membrane system	12
high spatial	12
see table	12
mm sodium	12
viral replicase	12
spike glycoproteins	12
golgi retention	12
hemagglutinin fusion	12
two subunits	12
partially folded	12
single molecular	12
regulatory proteins	12
default pathway	12
extracellular domain	12
membrane environment	12
treated cells	12
three dimensions	12
structural stability	12
reading frame	12
genetic material	12
interaction energy	12
legionella pneumophila	12
initial stage	12
positive curvature	12
interactions may	12
phospholipid vesicles	12
peptide structure	12
physiological processes	12
i atelocollagen	12
mhc i	12
specific interaction	12
large amount	12
times higher	12
neu gc	12
low molecular	12
innate immunity	12
cellular machinery	12
membrane bound	12
molten globule	12
using circular	12
protein family	12
hydrophobic peptides	12
mother cell	12
helical peptides	12
protein targets	12
carboxyl group	12
mouse model	12
remains unknown	12
residues within	12
interacting proteins	12
sandhoff disease	12
medical center	12
molecular dynamic	12
glycosylation sites	12
exchange chromatography	12
isolation membrane	12
antiviral agents	12
nmr data	12
biochemical studies	12
three distinct	12
putative fusion	12
united states	12
protein families	12
complete fusion	12
also called	12
colloid particles	12
transport pathway	12
ser ser	12
tau protein	12
therapeutic intervention	12
viral components	12
cell penetrating	12
numerous studies	12
contact width	12
spatial distribution	12
proteolytic processing	12
moisture transfer	12
fluorescence spectra	12
expression levels	12
griscelli syndrome	12
liquid crystalline	12
may serve	12
widely studied	12
also investigated	12
negative charge	12
vitro studies	12
intermolecular interactions	12
cell dna	12
bilayer structure	12
lower concentration	12
va ecls	12
mm naci	12
binding motif	12
coil binding	12
membrane may	12
organic solvent	12
islet amyloid	12
highly dynamic	12
membrane fission	12
membrane integrity	12
external domain	12
large amounts	11
analyzed using	11
flow rates	11
cancer patients	11
intracellular protein	11
well characterized	11
molecules per	11
fusion machinery	11
molecules across	11
membrane pores	11
surface functionalization	11
proteins also	11
blood vessels	11
biological properties	11
mesenchymal stem	11
major structural	11
particular interest	11
work will	11
i membrane	11
histidine residue	11
protein conformational	11
studies will	11
following sections	11
genetically encoded	11
signi cantly	11
acetic acid	11
transport across	11
immunogold labeling	11
conformational dynamics	11
diphtheria toxin	11
poliovirus replication	11
ultrastructural characterization	11
charged membranes	11
emission spectra	11
native conformation	11
dissociation constants	11
lateral heterogeneity	11
corona virus	11
eukaryotic cell	11
human coronavirus	11
specific amino	11
nmr experiments	11
translational modification	11
linked glycosylation	11
cell differentiation	11
quantum yield	11
adult respiratory	11
membrane regions	11
replicase protein	11
conserved among	11
data indicate	11
salt concentrations	11
viral spike	11
fluorescently labelled	11
play important	11
cellular compartments	11
channel opening	11
mm edta	11
currently available	11
million people	11
san diego	11
modified connexosomes	11
nfn materials	11
physiologically relevant	11
light harvesting	11
clamp technique	11
stimulated emission	11
domain aggregation	11
apical sorting	11
largely unknown	11
rat liver	11
several hundred	11
fluorescence recovery	11
fine structure	11
helicobacter pylori	11
molecular biophysics	11
membranes induced	11
af nity	11
deformation energy	11
membrane pore	11
tumor suppressor	11
rab proteins	11
renal replacement	11
obtained results	11
nonpermissive temperature	11
composite membrane	11
also involved	11
concerted action	11
recent progress	11
tyrosine residues	11
lag phase	11
double bond	11
force generation	11
gtpase activity	11
new approach	11
possible role	11
provided evidence	11
sample preparation	11
wheat germ	11
molecule inhibitors	11
potential therapeutic	11
reflection fluorescence	11
diffusion coefficients	11
particles formed	11
lipid mixtures	11
density lipoprotein	11
sensor chip	11
cleavable signal	11
results also	11
culture cells	11
folded proteins	11
coronavirus nonstructural	11
vesicles containing	11
lipid molar	11
microsomal membranes	11
free radical	11
molecular agents	11
saturated fatty	11
diseases including	11
water content	11
electron micrographs	11
two important	11
unsaturated fatty	11
human lung	11
terminal hydrophobic	11
di biofisica	11
single channel	11
cultured human	11
effector proteins	11
studies suggest	11
small diameter	11
antimicrobial agent	11
electrostatic force	11
functional roles	11
basolateral membranes	11
aureobasidium pullulans	11
liquid ordered	11
low resolution	11
two peptides	11
dynamic structure	11
photodynamic therapy	11
often used	11
candida albicans	11
autophagy machinery	11
dynamical properties	11
using confocal	11
sarcoplasmic reticulum	11
proton gradient	11
i proteins	11
cardiovascular disease	11
protein composition	11
will help	11
protein sequence	11
nucleocapsid protein	11
biophysical methods	11
probably due	11
spectroscopic studies	11
antimicrobial resistance	11
sequence information	11
based assay	11
active form	11
receptor signaling	11
antitumor activity	11
zippered er	11
ii membrane	11
biological sciences	11
endocytic processes	11
virus haemagglutinin	11
bending stiffness	11
gly leu	11
solution nmr	11
conventional electrospun	11
enter cells	11
membrane model	11
esr spectra	11
proteins containing	11
serial sections	11
care medicine	11
membrane domain	11
may induce	11
trace amounts	11
cellular organelles	11
unfolded protein	11
antimicrobial packaging	11
different steps	11
cell survival	11
main phase	11
still remains	11
structural motifs	11
accessory proteins	11
apparatus clsternae	11
one hand	11
binding energy	11
calcium ions	11
like protease	11
endocytic vesicles	11
becoming increasingly	11
lipid monolayers	11
antifungal activity	11
long term	11
chemical reactions	11
confocal microscope	11
materials science	11
membranotropic sequences	11
vitro transcription	11
major component	11
sequence alignment	11
fundamental role	11
deuterium exchange	11
synaptic transmission	11
peptide stapling	11
quality control	11
based methods	11
antimicrobial activities	11
determine whether	11
water disinfection	11
complex structures	11
therapeutic applications	11
dna replication	11
late stages	11
human cell	11
respiratory ecls	11
wafer surface	11
data analysis	11
direct observation	11
fluorescence imaging	11
acid long	11
recombinant protein	11
boiling point	11
new therapeutic	11
films incorporated	11
electrical potential	11
large numbers	11
therapeutic agents	11
intracellular calcium	11
herpes virus	11
environmental conditions	11
peptide variants	11
see section	11
resolution imaging	11
carboxyl groups	11
model lipid	10
containing vesicles	10
acrylic acid	10
rho gtpases	10
singlet oxygen	10
thermal denaturation	10
possible mechanism	10
lysine residues	10
hydrophobic segments	10
cellular level	10
molecular mass	10
royal society	10
pathogen interactions	10
magnetic nanoparticles	10
practical applications	10
plasmids expressing	10
organic materials	10
anchor domain	10
whole cells	10
thioester bond	10
approximately nm	10
lipid interaction	10
cellular environment	10
assembly process	10
gibbs free	10
replicase polyprotein	10
tertiary structures	10
findings suggest	10
mutagenesis studies	10
nanosized particles	10
proteins contain	10
acidic conditions	10
mm range	10
sh domains	10
structural model	10
nk cells	10
harvesting complex	10
i glycopeptides	10
concentration dependent	10
close apposition	10
activity may	10
also performed	10
hungarian academy	10
gm gangliosidoses	10
potential role	10
supramolecular structures	10
metabolic pathways	10
specific membrane	10
guanine nucleotide	10
particle shape	10
confocal fluorescence	10
significant role	10
physical principles	10
new possibilities	10
influenza virion	10
cell shape	10
help us	10
human plasma	10
cov nsp	10
transport mechanism	10
form stable	10
protein interface	10
phase diagrams	10
water flux	10
throughput screening	10
thermodynamic properties	10
shock protein	10
peptides containing	10
tumor cell	10
fever virus	10
three proteins	10
target proteins	10
ng ml	10
alzheimer disease	10
prepared using	10
major challenge	10
arginine residues	10
based method	10
conformational space	10
hcv ns	10
cell receptors	10
cell responses	10
structural elements	10
supported liquid	10
hcv replication	10
electrospinning technique	10
different properties	10
natural products	10
long range	10
venoarterial extracorporeal	10
high salt	10
independent endocytic	10
functional proteins	10
nfn nanomaterials	10
increasing interest	10
capillary forces	10
vacuolar targeting	10
along microtubules	10
forming toxins	10
one subunit	10
capsid protein	10
insect cells	10
measles virus	10
glass surfaces	10
liposomes containing	10
expression system	10
cell interior	10
mutant proteins	10
several proteins	10
internal fusion	10
might also	10
different concentrations	10
different kinds	10
sensory rhodopsin	10
number concentration	10
cmp wastewater	10
gracilaria chilensis	10
transmembrane pressure	10
cell signalling	10
cell therapy	10
detailed analysis	10
bulk solution	10
particularly important	10
lag time	10
may form	10
many important	10
paa nacl	10
time points	10
various proteins	10
amyloid fibril	10
experimental findings	10
structure analysis	10
low density	10
coronavirus nsp	10
cellular responses	10
dna fragments	10
channel formation	10
programmed cell	10
alkaline phosphatase	10
mean square	10
hydrophobic surfaces	10
er lumen	10
salt concentration	10
membrane traffic	10
also demonstrated	10
free system	10
specific cell	10
drug targets	10
domain swapping	10
leu val	10
ij loop	10
silver nanoparticles	10
transition metals	10
rna templates	10
different temperatures	10
three domains	10
gut microbiome	10
computer simulations	10
homology model	10
functional studies	10
convoluted membranes	10
mechanisms underlying	10
dependent membrane	10
bacterial growth	10
fission yeast	10
initial steps	10
internal membrane	10
high content	10
interface tension	10
deeper understanding	10
copper ions	10
drug target	10
biomolecular chemistry	10
large conformational	10
proteins found	10
black lipid	10
catalytic mechanism	10
virus ha	10
anthrax toxin	10
food packaging	10
spiky particles	10
study protein	10
several different	10
direct evidence	10
highly charged	10
supported membranes	10
cellular function	10
replication organelles	10
heavy metals	10
cholesterol dependence	10
transport proteins	10
neurological disorders	10
anticancer activity	10
chemical modification	10
biological research	10
relatively low	10
late endosome	10
key factor	10
computational design	10
viral infectivity	10
exhaled air	10
pediatric respiratory	10
fixed cells	10
different species	10
protein secretion	10
around nm	10
salt bridges	10
binding capacity	10
membrane bending	10
mass fraction	10
specific functions	10
sorting information	10
much smaller	10
fusion site	10
native protein	10
poliovirus infection	10
nmr structures	10
membrane interacting	10
metabolic labeling	10
cellular autophagy	10
clinical outcomes	10
light microscopy	10
conformational rearrangements	10
gtp hydrolysis	10
structural change	10
previous study	10
tight junction	10
membrane mimetic	10
intestinal epithelial	10
total resistance	10
class iii	10
simple passive	10
family members	10
higher concentrations	10
capillary interaction	10
receptor protein	10
top orientation	10
specific lipid	10
viral infections	10
virus binding	10
molecule studies	10
among patients	10
nmda receptors	10
novel membrane	10
positive charge	10
esn technique	10
sars cov	10
rat hepatocytes	10
embryonic stem	10
vice versa	10
complex assembly	10
protein structural	10
particulate matters	10
disordered protein	10
peptides may	10
fold increase	10
structural rearrangements	10
amyloid polypeptide	10
function relationship	10
hydroxyl group	10
single point	10
dynamic properties	10
successfully applied	10
intracellular localization	10
yellow fever	10
phosphate groups	10
human microbiome	10
mathematical model	10
terminal helix	10
cell function	10
protein misfolding	10
single stranded	10
result indicates	10
large quantities	10
high voltage	10
cvt pathway	10
targeted drug	10
environment measurement	10
imaging microscopy	10
molecular species	10
large surface	10
active proteins	10
viral envelopes	10
binding free	10
relevant role	10
retention signal	10
may affect	10
photon excitation	10
two fusion	10
novo design	10
cysteine protease	10
clavulanic acid	10
molecule force	10
peptide design	10
folded states	10
living organisms	10
proton transport	10
ground state	10
mechanical forces	10
safety issues	10
major groups	10
bactericidal activity	10
membrane invagination	10
parainfluenza virus	10
therapeutic target	10
collection efficiency	10
disulfide bridges	10
several tens	10
years ago	10
single amino	10
solution properties	10
causative agent	10
redox state	10
oxidative damage	10
apparatus cisternae	10
broad spectrum	9
solid state	9
lung cancer	9
hcv infection	9
infected vero	9
hcv entry	9
section ii	9
step towards	9
regenerative medicine	9
initial step	9
significant differences	9
classical molecular	9
highly efficient	9
viruses may	9
snare complexes	9
lower channel	9
parasitophorous vacuole	9
membranes composed	9
several factors	9
functional analysis	9
polyunsaturated fatty	9
amyloidogenic proteins	9
invariant chain	9
experimental approaches	9
target lipid	9
potential application	9
significant changes	9
deionized water	9
relaxation times	9
current knowledge	9
using electron	9
membranes membrane	9
induced vesicles	9
lipid environment	9
mhv nsp	9
fusion mediated	9
high membrane	9
increasing concentrations	9
conserved residues	9
different molecular	9
fast component	9
angle neutron	9
raft microdomains	9
mainly due	9
image analysis	9
dependent rna	9
fusion kinetics	9
atp synthesis	9
lytic peptides	9
multivesicular bodies	9
patient population	9
peptide conjugates	9
novel strategy	9
malaria parasite	9
molecules like	9
common features	9
biological relevance	9
containing liposomes	9
multiple sequence	9
small vesicles	9
important implications	9
hydrophilic residues	9
early secretory	9
national university	9
potential drug	9
magnetic particles	9
determined using	9
affinity purification	9
many cellular	9
umr cnrs	9
high temperature	9
based approach	9
next generation	9
conformational stability	9
arp complex	9
various cell	9
synthesized proteins	9
hiv fusion	9
coding sequences	9
thermotropic phase	9
statistical analysis	9
artificial lipid	9
packaging materials	9
conserved domain	9
low affinity	9
fusion glycoprotein	9
cells containing	9
proton translocation	9
magnetic fields	9
biological activities	9
two classes	9
significantly increased	9
catalytic cycle	9
helical bundle	9
refractive index	9
protein docking	9
two particles	9
ca membrane	9
active peptides	9
fusion occurs	9
fiber formation	9
protein fragments	9
every year	9
various kinds	9
antigen presentation	9
host protein	9
porous membrane	9
recent developments	9
known structure	9
lateral mobility	9
structure elements	9
closed conformation	9
fluorescent dye	9
peptide bonds	9
molecular chaperone	9
worth noting	9
using computational	9
various cellular	9
fusion inhibitor	9
surface pressure	9
uv light	9
particle interactions	9
sheet structures	9
acid peptide	9
nm thick	9
human serum	9
recognition receptors	9
ldl receptor	9
mechanical ventilation	9
matrix protein	9
glass transition	9
acid species	9
high aspect	9
adaptive immunity	9
structural determinants	9
oxidized cellulose	9
water penetration	9
structural differences	9
water soluble	9
polarized sorting	9
may vary	9
leukosis virus	9
yeast saccharomyces	9
th day	9
kbp bamhi	9
also possible	9
functionally active	9
heavy chain	9
structure changes	9
membranous web	9
new york	9
gp fusion	9
using various	9
binding affinities	9
trimer contacts	9
also contain	9
comparative analysis	9
second step	9
low temperatures	9
cellulose triacetate	9
research institute	9
surface proteins	9
terminal amphipathic	9
resistant membrane	9
three types	9
ultrasensitive sensors	9
large domain	9
granulosa cells	9
reticulum membranes	9
heterologous expression	9
autosomal dominant	9
spectroscopy measurements	9
bulk phase	9
novel therapeutic	9
bilayer membrane	9
exhaust gases	9
intact cells	9
extremely high	9
apposed membranes	9
vacuole targeting	9
proteins form	9
cd spectra	9
viral gene	9
chromatographic purification	9
bound organelles	9
gold surface	9
associated membrane	9
arterial extracorporeal	9
light induced	9
immunofluorescence microscopy	9
cardiac surgery	9
directly related	9
genome editing	9
studies indicate	9
neurological diseases	9
common feature	9
activation energy	9
translocation mechanism	9
must also	9
lipid organization	9
proline residues	9
mycobacterium tuberculosis	9
replication structures	9
fusion reactions	9
ubiquitously expressed	9
high selectivity	9
prion protein	9
significant contribution	9
per spherule	9
congenital diaphragmatic	9
drug release	9
lipid components	9
containing negatively	9
visible light	9
coupled receptor	9
might play	9
presentation will	9
hydrophobic mismatch	9
sample buffer	9
elongated particles	9
phage dna	9
time course	9
preliminary data	9
amide i	9
pharmaceutical industry	9
emission depletion	9
may act	9
ray structures	9
biomedical research	9
membrane bilayers	9
highly stable	9
human influenza	9
membrane proximal	9
volume ratio	9
highly ordered	9
particle orientation	9
trans golgi	9
computational approaches	9
drosophila melanogaster	9
negative control	9
dependent fusion	9
rna molecules	9