Questions

This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.

identifier question
cord-001152-v6uc0ijwIs RNA interference involved in intrinsic antiviral immunity in mammals?
cord-001527-x8yswouaobservations from household- based trials Estimating influenza vaccine efficacy from challenge and community- based study data Containing the accidental laboratory escape of potential pandemic influenza viruses Predicting"airborne"influenza viruses:( trans-) mission impossible?
cord-003143-n6b0r92eTwo years after pandemic influenza A/2009/ H1N1: what have we learned?
cord-274396-l611eisi␣ of Middle East respiratory syndrome Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen Antimalarial drug chloroquine counteracts activation of indoleamine( 2,3)-dioxygenase activity in human PBMC Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS- CoV-2 infection in vitro Hydroxychloroquine for SARS- CoV-2 infection: how did we get here?
cord-305698-fjd0rsrfWill the NSABB and the Academies be nimble enough to make concrete recommendations that are broadly acceptable within months?
cord-298773-vnmc6nqd: cord-298773-vnmc6nqd authors: Pfeiffer, Julie K. title: Is the Debate and “ Pause ” on Experiments That Alter Pathogens with Pandemic Potential Influencing Future Plans of Graduate Students and Postdoctoral Fellows?
cord-298773-vnmc6nqdFor example, factoring in retirement rates and potential loss of future investigators, what will the influenza/ MERS/ SARS virus fields look like in 2030, 2040, or 2050?
cord-281389-sht0yx4aWhy would the host dampen its immune response to infection?
cord-274663-zyzgk2z3Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs TDP-43: multiple targets, multiple disease mechanisms?
cord-308848-chvvtr0dCould an unrelated live attenuated vaccine serve as a preventive measure to dampen septic inflammation associated with COVID-19 infection?
cord-334463-nvu5tqxbThe poliovirus receptor: a hook, or an unzipper?
cord-012487-s920s5wb( PlsB) Regulation of phospholipid synthesis in Escherichia coli by guanosine tetraphosphate Regulation of membrane phospholipid synthesis by the relA gene: dependence on ppGpp levels Effect of ppGpp on Escherichia coli cyclopropane fatty acid synthesis is mediated through the RpoS sigma factor( sigmaS) Enzymology, genetics, and regulation of membrane phospholipid synthesis in Escherichia coli Bacterial membrane lipids: where do we stand?
cord-012487-s920s5wbBut what controls PlsB?
cord-012487-s920s5wbWhat might have caused the transient increase in fatty acid synthesis observed after translation inhibition?
cord-286587-x0wqtlxhCould they discover a treatment that might reduce the severity of COVID-19 infection and improve patient survival?
cord-286587-x0wqtlxhDo viral infections mimic bacterial sepsis?
cord-286587-x0wqtlxhYet, for those who develop severe disease, only one question matters:"will I live or die?
cord-296028-hqrd1e8pAn epistemological perspective on the value of gain- of- function experiments involving pathogens with pandemic potential Can limited scientific value of potential pandemic pathogen experiments justify the risks?
cord-296028-hqrd1e8psciences Promoting inherent safety Are we too risk- averse for inherent safety?
cord-264050-6zpw6itbWhat is a host?
cord-330315-upcf15q5Do viruses subvert cholesterol homeostasis to induce host cubic membranes?
cord-287892-bnqmwst8Enterovirus protein 2B po(u)res out the calcium: a viral strategy to survive?
cord-263357-krvei97rHow does the genomic analysis of HCoV- EMC expedite further research on this new human virus?
cord-263357-krvei97rWhat can analysis of its RNA genome tell us about this new human coronavirus?
cord-263357-krvei97rWhat features of the genome and its translational strategy are similar to or different from those of other coronaviruses?
cord-263357-krvei97rWhat is the relationship between HCoV- EMC and known coronaviruses?
cord-263357-krvei97rWhat questions must be answered to show whether HCoV- EMC is likely to cause an epidemic or adapt to become endemic in humans?
cord-353612-9ux181xgExperimental%20Metadata/ HCoV- EMC%20 infection%20in%20Calu-3%20cells/ begin.view?.
cord-353612-9ux181xgThe respiratory syncytial virus small hydrophobic protein is phosphorylated via a mitogen- activated protein kinase p38-dependent tyrosine kinase activity during virus infection Activation of the HIV-1 long terminal repeat by cytokines and environmental stress requires an active CSBP/ p38 MAP kinase Mitogen activated protein kinase inhibitors: where are we now and where are we going?
cord-352096-cc3dzyclThe innate immune system: fighting on the front lines or fanning the flames of COVID-19?
cord-324978-9qfhsj3nDid MERS- CoV truly emerge as a human pathogen in 2012, or were cases of cryptic infection not appreciated because of a lack of suitable diagnostic tests?
cord-324978-9qfhsj3nWhat are the roles of bats, if any, as reservoirs of MERS- CoV?
cord-331361-pd9lt4n2: why are they so deadly?
cord-331361-pd9lt4n2Human T- cell leukemia virus type 1 envelope glycoprotein gp46 interacts with cell surface heparan sulfate proteoglycans Heparan sulphate proteoglycans and viral vectors: ally or foe?
cord-331361-pd9lt4n2Nipah virus- a potential agent of bioterrorism?
cord-290297-efo9f7c5First, are there synergic interactions between the SARS- CoV-2 virus and certain coinfecting bacteria?
cord-290297-efo9f7c5Second, does coinfection with antibiotic- resistant bacteria affect disease severity?
cord-001672-7lh8iqm1Does it give us elapsed time for a 50% chance, or an 80% chance?
cord-001672-7lh8iqm1Does it give us the elapsed time for a 10% chance that an LAI occurs?
cord-289360-h6wvx7gwA strategy to estimate unknown viral diversity in mammals Is the debate and"pause"on experiments that alter pathogens with pandemic potential influencing future plans of graduate students and postdoctoral fellows?
cord-289360-h6wvx7gwmBio Is virology dead?
cord-256550-72i1x02fIs an E of 0.1%, 1%, or 10% too high?
cord-256550-72i1x02fIs it really acceptable for a manufacturing company to dump mercury in the ocean, because that one factory's output would not be enough to pose any danger to us when we consume fish?
cord-256550-72i1x02fIs there nothing wrong if I buy a gas guzzler that gets 10 miles per gallon and has faulty emissions control, since my car's individual contribution to climate destruction is minimal?
cord-256550-72i1x02fThe first question to be asked is"what is the probability of at least one escape from one of the n labs conducting research on the pathogen for y years?"
cord-256550-72i1x02fWhat if everyone researched live smallpox?"has been implicitly answered according to Kant's categorical imperative by everyone agreeing to limit research to two places.
cord-335432-9aszklx3Must a name mean something?
cord-335432-9aszklx3At this juncture, it is reasonable to ask,"is it possible to extract ourselves from this rabbit hole?
cord-335432-9aszklx3Does the name aTRIP help, or does it just add more complexity to this muddle?
cord-335432-9aszklx3How did we find ourselves in this lexiconic morass?
cord-335432-9aszklx3What does it mean?"
cord-335432-9aszklx3When Humpty met Alice, he asked the intrepid adventurer"tell me your name and your business?"
cord-287487-qeltdch7Can MHV replicase proteins mediate high- fidelity replication without ExoN proofreading?
cord-287487-qeltdch7Can MHV replicase proteins mediate high- fidelity replication without ExoN proofreading?
cord-287487-qeltdch7In the face of selective pressure for increased fidelity, why did MHV- ExoN(-) not revert?
cord-287487-qeltdch7The role of mutational robustness in RNA virus evolution Plaques formed by mutagenized viral populations have elevated coinfection frequencies Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis Does mutational robustness inhibit extinction by lethal mutagenesis in viral populations?
cord-287487-qeltdch7Which mechanisms other than increased fidelity can compensate for the loss of proofreading?
cord-287487-qeltdch7Which mechanisms other than increased fidelity might account for MHV- ExoN(-) P250 nucleoside analog resistance?
cord-287487-qeltdch7hepatitis virus A59 mRNA 2: indications for RNA recombination between coronaviruses and influenza C virus Mouse hepatitis virus S RNA sequence reveals that nonstructural proteins ns4 and ns5a are not essential for murine coronavirus replication Luxury at a cost?
cord-287487-qeltdch7not revert?
cord-287487-qeltdch7nsp10 is a critical regulator of viral RNA synthesis Ribavirin's antiviral mechanism of action: lethal mutagenesis?