trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
the presence of	184
as well as	179
in order to	173
one of the	134
of the protein	132
based on the	120
structure of the	101
the number of	98
the active site	95
in this study	91
in the presence	87
due to the	80
the role of	80
the effect of	78
fake av software	76
was used to	75
analysis of the	73
the formation of	68
the use of	67
the development of	66
crystal structure of	65
sites in the	65
in terms of	63
a number of	61
we found that	58
the effects of	56
in addition to	55
involved in the	55
of the most	54
of the enzyme	54
can be used	52
part of the	52
the cleavage site	52
to identify the	50
a variety of	50
is one of	50
the majority of	50
been shown to	49
it has been	49
understanding of the	48
acute respiratory syndrome	47
severe acute respiratory	47
respiratory syndrome coronavirus	46
the case of	45
the structure of	45
the importance of	45
responsible for the	45
found to be	44
to investigate the	44
the absence of	44
the distribution of	44
the mechanism of	43
be used to	43
the fact that	43
the amino acid	42
the secondary site	42
according to the	42
some of the	41
to determine the	41
of the human	41
in this work	40
as shown in	40
amino acid sites	40
located in the	40
in the case	40
amino acid residues	40
amino acid sequence	40
as a result	39
the design of	39
the present study	39
such as the	38
compared to the	38
the activity of	38
suggest that the	38
under positive selection	38
between the two	38
were able to	38
in the absence	38
of the two	37
the frad sites	37
a series of	36
each of the	36
is based on	36
most of the	36
has been shown	36
there is a	36
canonical cleavage sites	35
to be a	35
shown in fig	35
of amino acid	35
results suggest that	34
cleavage sites of	34
of the cleavage	34
a combination of	34
consistent with the	34
the location of	33
at each site	33
over the past	33
the identification of	33
in response to	33
well as the	33
in the caribbean	33
were used to	33
related to the	33
show that the	33
the crystal structure	33
a total of	33
the ability of	32
and in the	32
multiple sequence alignment	32
the results of	32
the regulation of	32
site in the	32
the binding of	32
members of the	32
is involved in	32
results show that	31
likely to be	31
binding to the	31
the analysis of	31
to study the	31
the function of	31
were found to	31
of frad sites	31
of the sars	31
we show that	31
have shown that	31
to the primary	30
on the other	30
function of the	30
region of the	30
the level of	30
used as a	30
are able to	30
the influence of	30
are involved in	30
the primary site	30
binding of the	30
the ability to	30
changes in the	29
of a protein	29
the most common	29
a result of	29
the surface of	29
was supported by	29
the aim of	29
in the a	29
of positive selection	29
structural and functional	29
showed that the	29
of the viral	29
cleavage of the	28
p and p	28
is required for	28
of the s	28
east respiratory syndrome	28
end of the	28
shown to be	28
in which the	27
positively selected sites	27
residues in the	27
presence of a	27
at the same	27
sialic acid binding	27
cleavage sites in	27
based on a	27
a set of	27
to assess the	27
active site of	27
was carried out	27
is essential for	27
of the virus	27
middle east respiratory	26
that can be	26
a role in	26
found that the	26
present in the	26
processing of the	26
have been identified	26
characterization of the	26
a range of	26
suggests that the	26
the relationship between	26
properties of the	26
used in the	26
to that of	26
that of the	26
interaction with the	26
are known to	26
be involved in	26
found in the	26
role in the	26
derived from the	26
sequence of the	25
of the three	25
the lack of	25
role of the	25
known to be	25
the interaction between	25
we were able	25
the binding sites	25
in the protein	25
the treatment of	25
the other hand	25
in the same	25
in complex with	25
the rate of	25
on the surface	25
the context of	25
by means of	25
the top end	25
of this study	25
the local structures	24
large number of	24
we propose that	24
of the p	24
infectious bronchitis virus	24
the wild type	24
to be the	24
the efficiency of	24
of the n	24
hepatitis c virus	24
observed in the	24
the binding site	24
the interaction of	24
influenza a virus	24
site of the	24
of amino acids	23
supported by the	23
effect of the	23
the a site	23
sites of the	23
of the ribosome	23
of the data	23
was used for	23
activation of the	23
the cleavage sites	23
positive selection in	23
in the study	23
an important role	23
structures of the	23
the end of	22
insights into the	22
of the coronavirus	22
a and b	22
the mdi spacer	22
was used as	22
the cleavage of	22
are likely to	22
interactions between the	22
we developed a	22
depending on the	22
to understand the	22
crystal structures of	22
structure and function	22
is an important	22
the cut site	22
in the present	22
liu et al	22
this work was	22
surface coverage ratio	21
to analyze the	21
was found to	21
the expression of	21
in the active	21
sites under positive	21
is the most	21
the detection of	21
also known as	21
the process of	21
structure of a	21
the study of	21
the evolution of	21
sox cut sites	21
associated with the	21
there is no	21
total number of	21
of local structures	21
is known to	21
identification of a	20
mdi spacer use	20
there was no	20
in agreement with	20
activity of the	20
in the context	20
isothermal titration calorimetry	20
differences in the	20
the p site	20
proteolytic processing of	20
its interaction with	20
for the first	20
used for the	20
the spike protein	20
features of the	20
the shift site	20
the impact of	20
prediction of protein	20
of the cell	19
in our study	19
wide range of	19
clpro cleavage sites	19
b and c	19
work was supported	19
proteins in the	19
domain of the	19
of the study	19
contribute to the	19
of a novel	19
can be found	19
position of the	19
important role in	19
are shown in	19
of mdi spacers	19
in the two	19
followed by a	19
results indicate that	19
in the cell	19
in contrast to	19
the size of	19
a large number	19
for the design	19
cleavage site in	19
of the proteins	19
suggested that the	19
regulation of the	19
molecular dynamics simulations	18
characterization of a	18
resulted in a	18
has been used	18
the structure and	18
is consistent with	18
predicted to be	18
is used to	18
is responsible for	18
the potential to	18
the properties of	18
close to the	18
a wide range	18
our understanding of	18
and it is	18
regions of the	18
of the complex	18
considered to be	18
acts as a	18
pc cleavage site	18
has also been	18
amino acid sequences	18
binding sites for	18
which can be	18
corresponding to the	18
the same time	18
coronavirus spike protein	18
in vitro and	18
a subset of	18
the surface coverage	18
because of the	18
the basis of	18
compared with the	18
will be presented	18
it is a	18
in table s	18
of the binding	18
in the p	18
length of the	18
insight into the	18
on the protein	18
side of the	18
addition to the	18
human immunodeficiency virus	18
located at the	18
is able to	18
increase in the	18
with respect to	18
due to their	18
in the human	18
the addition of	18
binding sites of	18
many of the	18
of the c	17
is associated with	17
size exclusion chromatography	17
similar to that	17
have also been	17
vitro and in	17
our results show	17
of the target	17
the most important	17
nuclear magnetic resonance	17
in this case	17
of binding sites	17
we used a	17
the web pages	17
indicators of traditional	17
to bind to	17
is a key	17
of influenza virus	17
is composed of	17
as part of	17
to determine whether	17
to evaluate the	17
of a new	17
have been developed	17
we have developed	17
of the other	17
this suggests that	17
in escherichia coli	17
binding sites in	17
the names of	17
software distribution sites	17
been found to	17
and n a	17
substrate specificity of	17
member of the	17
be due to	17
the activation of	17
here we present	17
to have a	17
at the p	17
nature of the	17
to predict the	17
are located in	17
sequence and structure	17
similar to the	17
the performance of	17
have been shown	17
the protein and	17
as compared to	17
binding sites on	17
these results suggest	17
change in the	17
are responsible for	17
the prediction of	17
of traditional management	17
the md simulations	17
relative to the	17
shown in table	17
studies have shown	17
from the md	16
of influenza a	16
the range of	16
the dimer interface	16
site and the	16
all of the	16
we used the	16
is a major	16
effect on the	16
appears to be	16
the host cell	16
for the treatment	16
it is not	16
to be involved	16
in combination with	16
stability of the	16
identified in the	16
interaction between the	16
it is possible	16
information on the	16
the affinity of	16
primary binding site	16
and can be	16
of the ligand	16
local structures and	16
evolution of the	16
in the sars	16
of fake av	16
in the development	16
position in the	16
of the a	16
the l p	16
richardson et al	16
indicated that the	16
included in the	16
was shown to	16
indicates that the	16
daye et al	16
the probability of	16
and in vivo	16
the sox cut	16
due to its	16
were used for	16
the contribution of	16
used to identify	16
we showed that	16
of the surface	16
the amount of	16
rest of the	16
of the river	16
use of the	16
as a model	16
suggesting that the	16
formation of a	16
the production of	16
to examine the	16
in the n	16
we have used	16
is due to	16
in the top	16
the concentration of	16
amino acid composition	16
of the local	16
structural basis for	15
in this paper	15
to elucidate the	15
half of the	15
results showed that	15
the processing of	15
the length of	15
can lead to	15
and function of	15
obtained from the	15
surface of the	15
more likely to	15
we analyzed the	15
binding site of	15
s and s	15
are based on	15
the first time	15
in the future	15
p to p	15
at the end	15
to provide a	15
a wide variety	15
of the membrane	15
putative cleavage sites	15
a key role	15
ribosomal protein l	15
of a single	15
the nature of	15
we find that	15
to each other	15
listed in table	15
the severe acute	15
be used as	15
majority of the	15
of the peptide	15
fact that the	15
the degree of	15
the percentage of	15
affinity of the	15
has not been	15
in the s	15
a neural network	15
indicating that the	15
the canonical cleavage	15
the viral community	15
the secondary structure	15
the assembly of	15
the method is	15
the accuracy of	15
of the recombinant	15
the rest of	15
which may be	15
of the catalytic	15
wide variety of	15
of these proteins	15
bind to the	15
may be a	15
expression of the	15
some of these	15
we investigated the	15
of the interaction	15
model of the	15
the existence of	15
at the c	15
belongs to the	15
extracted from the	15
formation of the	15
and characterization of	15
were found in	15
there was a	15
the inhibition of	14
the position of	14
and for the	14
in the past	14
of the sox	14
to the protein	14
are capable of	14
and the other	14
of the main	14
at least one	14
was set to	14
the crystal structures	14
the action of	14
ligand binding sites	14
knowledge of the	14
the composition of	14
is supported by	14
downstream of the	14
to the secondary	14
of the cut	14
as previously described	14
the structural and	14
structural characterization of	14
the ratio of	14
the main river	14
part of a	14
with the same	14
of cyber threats	14
to the p	14
resulted in the	14
the accumulation of	14
of the predicted	14
the protein is	14
is essential to	14
the interaction with	14
for the development	14
the binding affinity	14
the origin of	14
the protein surface	14
that it is	14
structures and functions	14
to form a	14
on the basis	14
it can be	14
sites on the	14
a measure of	14
of protein structure	14
indicate that the	14
than that of	14
thought to be	13
the results show	13
that there is	13
a group of	13
there is an	13
of the mrna	13
peterson et al	13
of the receptor	13
conformation of the	13
proteins of the	13
is mediated by	13
the mine site	13
mechanism of the	13
is difficult to	13
are present in	13
the protein structure	13
interact with the	13
we also found	13
revealed that the	13
demma et al	13
are listed in	13
studies of the	13
of the genome	13
to the active	13
divided into two	13
interaction of the	13
the first step	13
of the proteolytic	13
the stability of	13
the cell surface	13
is necessary for	13
the barrow burn	13
the course of	13
information about the	13
frequency per site	13
to frad sites	13
the kinetics of	13
the sequence of	13
these sites are	13
differences between the	13
due to a	13
the application of	13
transmissible gastroenteritis virus	13
we have identified	13
terms of the	13
of the mdi	13
the most abundant	13
one or more	13
concentration of the	13
to interact with	13
is likely to	13
the free energy	13
coronavirus infectious bronchitis	13
were shown to	13
to the presence	13
of the active	13
dependent on the	13
be able to	13
we believe that	13
key role in	13
the pol zn	13
a method for	13
conflict of interest	13
bound to the	13
methods for detecting	13
at the time	13
cleavage sites were	13
open reading frame	13
in the field	13
have been reported	13
play an important	13
the study area	13
that have been	13
be used in	13
been identified in	13
the substrate specificity	13
to understand how	13
leading to the	13
domain names of	13
in the c	13
in term of	13
of which are	13
light on the	13
this site is	13
study was to	13
the sialic acid	13
of the e	13
the concept of	13
is expected to	13
the numbers of	13
names of cyber	13
used to determine	13
and dynamics of	13
the primary binding	13
to explore the	13
the reading frame	12
the present work	12
u r n	12
distribution of the	12
a member of	12
p r e	12
residues of the	12
at least of	12
protein structure and	12
of the large	12
the frequency of	12
it may be	12
cover per transect	12
the dynamics of	12
the generation of	12
amino acid substitutions	12
we present the	12
size of the	12
at least two	12
of a large	12
determine whether the	12
of the total	12
intrinsically disordered proteins	12
components of the	12
r n a	12
upstream of the	12
for each site	12
small island tourism	12
small number of	12
o o f	12
we demonstrated that	12
of them are	12
in relation to	12
of the present	12
when compared to	12
is possible that	12
basis for the	12
of the shift	12
believed to be	12
the university of	12
may contribute to	12
affinity for the	12
has been identified	12
proteinase cleavage sites	12
subunit of the	12
this is the	12
in the regulation	12
we focused on	12
which is a	12
in the native	12
shown that the	12
a l p	12
in site a	12
l p r	12
is critical for	12
c and d	12
is shown in	12
pol zn site	12
which is the	12
results demonstrate that	12
with the aim	12
the n a	12
shown in figure	12
comparison of the	12
of the species	12
in the nucleus	12
the quality of	12
expressed in the	12
to test whether	12
n a l	12
the multiple sequence	12
form of the	12
are the most	12
previous studies have	12
compared to other	12
and of the	12
and that the	12
is important for	12
we are able	12
frad sites and	12
the orf a	12
p r o	12
protein in the	12
in determining the	12
c and c	12
o u r	12
more than of	12
development of a	12
are associated with	12
acid binding sites	12
used to predict	12
we hypothesize that	12
r o o	12
to the enzyme	12
away from the	12
referred to as	12
central nervous system	12
and cover per	12
the beginning of	12
be important for	12
surface plasmon resonance	12
which has been	12
prior to the	12
be found in	12
it should be	12
a family of	12
sites that are	12
the s proteasome	12
mutations in the	12
protein data bank	12
single amino acid	12
specificity of the	12
by the presence	12
the structures of	12
characteristics of the	12
is the first	12
in the brain	12
the emergence of	12
the result of	12
j o u	12
the pathogenesis of	12
results in the	12
the exception of	12
the introduction of	12
by using the	12
at the site	12
the possibility of	11
to create a	11
then used to	11
is thought to	11
amino acid changes	11
two of the	11
have been found	11
allowed us to	11
are consistent with	11
the proportion of	11
evolutionary history of	11
is crucial for	11
dimensional structure of	11
we present a	11
by the clpro	11
a novel coronavirus	11
the overlapping region	11
as in the	11
linked to the	11
depends on the	11
were obtained by	11
cover per quadrat	11
potential cleavage sites	11
the p position	11
we have shown	11
at this site	11
positive selection at	11
use of a	11
terminal domain of	11
the recombinant mbp	11
the effectiveness of	11
predicted to have	11
the characterization of	11
demonstrated that the	11
secondary structure of	11
it is likely	11
we report the	11
focused on the	11
the e site	11
was able to	11
agreement with the	11
a model of	11
is that the	11
of the molecular	11
of these sites	11
to be cleaved	11
this study was	11
of the substrate	11
act as a	11
active site and	11
functionally important residues	11
representation of the	11
cut site in	11
amino acids in	11
based on their	11
residues at the	11
high degree of	11
a model for	11
is related to	11
the time of	11
the orf b	11
sequences of the	11
binding domain of	11
of the first	11
has been found	11
we observed that	11
in the binding	11
difference between the	11
and the c	11
effects of the	11
in recent years	11
an example of	11
sites in proteins	11
positive selection and	11
in line with	11
this may be	11
we did not	11
are required for	11
of the zymogen	11
control of the	11
be used for	11
av software families	11
sox cut site	11
for binding to	11
have been proposed	11
serve as a	11
in the pdb	11
been used to	11
in a protein	11
of sites with	11
medical college and	11
are essential for	11
of the amino	11
and does not	11
of tourism growth	11
the synthesis of	11
in the ed	11
of the four	11
we have been	11
required for the	11
removal information for	11
to measure the	11
proteins involved in	11
profile of the	11
the hd c	11
van der waals	11
the purpose of	11
x xxy yyz	11
in the second	11
binding sites and	11
their ability to	11
pp a ab	11
importance of the	11
of the rna	11
demonstrate that the	11
university of california	11
study of the	11
summarized in table	11
to obtain a	11
of hepatitis c	11
government of aruba	11
mutation of the	11
cleavage site of	11
of protein function	11
with the exception	11
in a variety	11
was added to	11
it was shown	11
that are not	11
a database of	11
we have also	11
could be used	11
similar to those	11
the viral genome	11
expressed in e	11
proteins can be	11
the release of	11
associated with a	11
at the n	11
able to identify	11
rational design of	11
high levels of	11
of the same	11
play a role	11
a method to	11
an increase in	11
analysis of protein	11
in the data	11
to be more	11
the reference laboratory	11
composition of the	11
an analysis of	11
dynamics of the	11
this study is	11
were detected in	11
with a high	10
supplementary material online	10
in saccharomyces cerevisiae	10
the murine coronavirus	10
of proteins in	10
led to the	10
in our laboratory	10
a highly conserved	10
existence of a	10
et drug sites	10
more than one	10
to those of	10
this study we	10
of the tree	10
the functions of	10
cover per site	10
in some cases	10
any of the	10
of the district	10
the occurrence of	10
for each of	10
for cyber threats	10
the dissociation constant	10
of sialic acid	10
the distance between	10
of severe acute	10
resonance energy transfer	10
at c for	10
will be discussed	10
protein interaction sites	10
out of the	10
focusing on the	10
into account the	10
of the fusion	10
the past decade	10
of the residues	10
the large subunit	10
adoption of mdi	10
the probability that	10
synonymous and nonsynonymous	10
site loop is	10
kim et al	10
the intrinsically disordered	10
number of the	10
were identified as	10
enzyme in the	10
furin correction factor	10
of this protein	10
n d s	10
data are available	10
in the secondary	10
sites that were	10
and p sites	10
is cleaved by	10
cleavage sites are	10
in other words	10
in the process	10
along with the	10
we demonstrate that	10
need to be	10
that the binding	10
in the range	10
aim of the	10
in the vicinity	10
a protein structure	10
the discovery of	10
reactive oxygen species	10
the human genome	10
of both the	10
of the sequences	10
the native state	10
of the sequence	10
analysis of a	10
of the second	10
of the new	10
of mdi spacer	10
has been previously	10
to play a	10
confidence level of	10
web server for	10
method for the	10
very close to	10
primary and secondary	10
studies on the	10
a part of	10
have not been	10
was shown that	10
n et al	10
was based on	10
in mammalian cells	10
mechanism of action	10
enzymatic activity of	10
are thought to	10
suitable sites for	10
selected amino acid	10
participate in the	10
the data set	10
plays a role	10
the control of	10
in the other	10
structure and dynamics	10
better understanding of	10
is important to	10
context of the	10
it is also	10
step in the	10
ability to bind	10
the folding of	10
used to analyze	10
for the same	10
of serine proteases	10
inhibition of the	10
of the putative	10
for the detection	10
cov and sars	10
the extent of	10
recognition of the	10
of the rbd	10
it is essential	10
the construction of	10
were enriched in	10
of the native	10
multiple sequence alignments	10
sites with a	10
p x r	10
have been described	10
than in the	10
a small number	10
local structures are	10
and on the	10
to better understand	10
status of the	10
were identified in	10
to compare the	10
are predicted to	10
the field of	10
of the novel	10
for the prediction	10
to the target	10
proved to be	10
it is important	10
influence of the	10
to act as	10
tourism in the	10
adjacent to the	10
found to bind	10
of the major	10
of proteins that	10
it does not	10
associated with this	10
complex with the	10
orders of magnitude	10
concentrations of the	10
a lack of	10
our results suggest	10
result of the	10
family of proteins	10
the hydrolysis of	10
of the m	10
be considered as	10
to the human	10
d n d	10
at the molecular	10
the characteristics of	10
in protein structures	10
may also be	10
in the nt	10
been proposed to	10
especially in the	10
scheyvens and biddulph	10
expected to be	10
in the formation	10
this is an	10
could not be	10
a library of	10
added to the	10
in the early	10
in the interaction	10
this work we	10
in living cells	10
and may be	9
is similar to	9
inserted into the	9
j and j	9
the icu rotation	9
the de novo	9
in this context	9
reach frad sites	9
be cleaved by	9
to predict protein	9
is the only	9
and a c	9
the enzyme was	9
our ability to	9
are found in	9
and the number	9
portion of the	9
were used as	9
far from the	9
pseudo amino acid	9
new health care	9
are critical for	9
search results for	9
international tourism demand	9
the molecular basis	9
c antigen sites	9
which in turn	9
at all sites	9
in this way	9
can also be	9
to detect the	9
to the motif	9
we use the	9
supplementary table s	9
mouse hepatitis virus	9
were carried out	9
be the most	9
we have found	9
these results demonstrate	9
to overcome the	9
and p positions	9
the past years	9
ligand binding site	9
n and d	9
diversity of the	9
distance between the	9
alignment of the	9
findings suggest that	9
dependent rna polymerase	9
interaction in the	9
is dependent on	9
nsp and nsp	9
to confirm the	9
of the site	9
well as a	9
c for h	9
location of the	9
structural basis of	9
the recombinant protein	9
and found that	9
sites were predicted	9
a model system	9
inhibitors have been	9
is a powerful	9
number of patients	9
wang et al	9
model for the	9
site at the	9
to improve the	9
in the literature	9
sites of mers	9
these frad sites	9
amino acid species	9
resulting in a	9
cleavage sites and	9
allows us to	9
been shown that	9
novel coronavirus from	9
adaptive evolution of	9
have demonstrated that	9
aim of this	9
binding site in	9
of the spike	9
been implicated in	9
the s protein	9
of the orf	9
of the structure	9
be noted that	9
a high degree	9
positively selected amino	9
the proteolytic processing	9
nt surrounding the	9
is capable of	9
and evolution of	9
together with the	9
these results indicate	9
the past two	9
a new coronavirus	9
we note that	9
only in the	9
the sars coronavirus	9
structural studies of	9
interacts with the	9
there are no	9
in the crystal	9
the neural network	9
have the potential	9
levels of the	9
the amino acids	9
the vicinity of	9
in the yeast	9
a region of	9
on the web	9
a single protein	9
a crucial role	9
orf b peptide	9
the folding and	9
was applied to	9
and secondary structure	9
for this purpose	9
h and h	9
binding sites are	9
the order of	9
of at least	9
number of species	9
survey of the	9
in the cleavage	9
were extracted from	9
is represented by	9
of the distribution	9
to test the	9
of middle east	9
in the current	9
mutation in the	9
the mechanisms of	9
the m a	9
college and hospital	9
in the spike	9
at these sites	9
lu et al	9
hall and williams	9
case of the	9
tseng et al	9
the evolutionary history	9
assembly of the	9
to use the	9
barriers and facilitators	9
the need for	9
that is not	9
of the sites	9
a mixture of	9
than the other	9
to the high	9
the conservation of	9
h n virus	9
may lead to	9
in a single	9
of codon substitution	9
the ebola virus	9
which are the	9
this is consistent	9
the interactions between	9
and the resulting	9
binding site on	9
in both the	9
of the l	9
presence of the	9
to describe the	9
the cut sites	9
interactions with the	9
the search results	9
was found in	9
the family of	9
terminus of the	9
provided by the	9
coli k genome	9
abundant in the	9
like cleavage site	9
the hypothesis that	9
and identification of	9
is an essential	9
the transition transversion	9
the creation of	9
mediated by the	9
within the same	9
have focused on	9
li et al	9
and d s	9
in the first	9
is likely that	9
as a consequence	9
that there was	9
contrast to the	9
the changes in	9
leading to a	9
from the data	9
and mass spectrometry	9
the resilience of	9
using nmr spectroscopy	9
defined as the	9
we propose a	9
the same as	9
and c antigen	9
immunodeficiency virus type	9
of tourism in	9
the two sites	9
the ribosome and	9
the total number	9
molecular basis of	9
conformational changes of	9
as compared with	9
the furin correction	9
that they have	9
is known about	9
the domain names	9
analysis showed that	9
of the search	9
detecting positive selection	9
of our study	9
amino acids and	9
has been suggested	9
respect to the	9
positive darwinian selection	9
correlated with the	9
proteolytic sites in	9
is located in	9
it is difficult	9
have found that	9
of the clpro	9
protein local structures	9
distance from the	9
the positive set	9
were performed using	9
the pc cleavage	9
shed light on	9
the red queen	9
that at least	9
sites are located	9
data suggest that	9
of the proprotein	9
to be highly	9
and analysis of	9
used in this	9
the phylogenetic tree	9
by using a	9
functional sites in	9
department of chemistry	9
of health care	9
the protease activity	9
seen in the	9
with more than	9
a serine protease	9
acid sites under	9
closely related to	9
on the sensor	8
in cancer cells	8
ligand binding to	8
the coronavirus infectious	8
functional analysis of	8
the northern territory	8
comparison between the	8
a confidence level	8
the endoplasmic reticulum	8
the enzyme in	8
the dissociation constants	8
could also be	8
nucleic acid extraction	8
past two decades	8
be divided into	8
was the most	8
per site frequency	8
for the study	8
each of these	8
as shown by	8
mediated by a	8
explanation for the	8
of the pc	8
of the ebola	8
two binding sites	8
mdi spacer adoption	8
from the active	8
this protein is	8
as a function	8
relationship between the	8
by comparing the	8
the significance of	8
molecular determinants of	8
the value of	8
selection in the	8
have been studied	8
to calculate the	8
known as the	8
are expected to	8
the primary and	8
sequences in the	8
free energies of	8
cleavage site motifs	8
in the cytoplasm	8
binds to the	8
of the correct	8
free energy of	8
the loss of	8
the bottom of	8
the dry ridge	8
the catalytic domain	8
was performed on	8
the nt surrounding	8
in the rms	8
and the subsequent	8
are believed to	8
step of the	8
in most cases	8
widely used in	8
is in the	8
was determined by	8
not yet been	8
in the design	8
with that of	8
of the interacting	8
of the host	8
k genome sequence	8
caused by the	8
human coronavirus e	8
on the structure	8
the complexity of	8
it was found	8
degradation by the	8
the web page	8
only a few	8
of the genetic	8
we studied the	8
enzyme active site	8
seems to be	8
new insights into	8
and used to	8
of the top	8
data on the	8
the adoption of	8
has shown that	8
whether or not	8
note that the	8
essential for the	8
to the free	8
these proteins are	8
of this work	8
for all sites	8
that the majority	8
target for the	8
among all the	8
in patients with	8
nedd and nedd	8
frad sites using	8
secondary binding site	8
floating catchment area	8
are difficult to	8
the specificity of	8
is caused by	8
belong to the	8
the centre of	8
ziebuhr and siddell	8
based prediction of	8
of protein structures	8
amber force field	8
of the manuscript	8
role of this	8
dengue virus serotype	8
is the major	8
of small molecules	8
in the middle	8
processing by the	8
here we report	8
the adoption process	8
the amber force	8
as described above	8
binding affinity of	8
of the h	8
the department of	8
resulting in the	8
a amino acid	8
is believed to	8
of all the	8
we have previously	8
was found that	8
state of over	8
the protein to	8
amino acid substitution	8
cleavage site motif	8
attached to the	8
conformational changes in	8
solution structure of	8
a basis for	8
for the analysis	8
the association rates	8
nonsynonymous and synonymous	8
of sequence and	8
influenza a viruses	8
based on this	8
used as the	8
molecular mechanism of	8
we searched for	8
is divided into	8
has the potential	8
was confirmed by	8
for treatment of	8
simian immunodeficiency virus	8
of proteins with	8
be responsible for	8
peptides and proteins	8
is considered to	8
n a and	8
was mutated to	8
d and e	8
graduate school of	8
the escherichia coli	8
shown that a	8
is a highly	8
in cell culture	8
to be important	8
followed by the	8
we have investigated	8
were used in	8
academy of sciences	8
observed for the	8
frad sites that	8
crucial for the	8
have developed a	8
to be under	8
those of the	8
the protein data	8
of the folding	8
in the treatment	8
is crucial to	8
that has been	8
the goal of	8
of the method	8
we have studied	8
core of the	8
implicated in the	8
as determined by	8
in case of	8
the results showed	8
the molecular mechanism	8
that the n	8
were observed in	8
reveals that the	8
based on these	8
is found in	8
focus on the	8
to characterize the	8
interest in the	8
to test this	8
the molecular level	8
d n and	8
small molecule inhibitors	8
work was to	8
of the structural	8
in the new	8
of this enzyme	8
the ubiquitin proteasome	8
the aid of	8
in the substrate	8
small angle x	8
of the entire	8
at the s	8
to a new	8
in the following	8
context of a	8
in a specific	8
presence of glycans	8
which could be	8
necessary for the	8
oseltamivir and zanamivir	8
we conclude that	8
health care service	8
that do not	8
are more likely	8
the virus to	8
but it is	8
the fusion protein	8
frequency and cover	8
energies of binding	8
of small island	8
in eukaryotic cells	8
at each position	8
information for cyber	8
dodds and butler	8
function in the	8
relative accessibility index	8
many of these	8
the enzyme is	8
in this review	8
were incubated with	8
a component of	8
of the short	8
find that the	8
gene of the	8
the target protein	8
the sequences of	8
accounts for the	8
was consistent with	8
we suggest that	8
of the murine	8
its ability to	8
to find out	8
be useful in	8
shows that the	8
it was not	8
this study were	8
retrieved from the	8
codon in the	8
hd c site	8
at room temperature	8
species in the	8
amino acid residue	8
has been described	8
we characterized the	8
the central nervous	8
at the reference	8
in the complex	8
the center of	8
and in vitro	8
the authors declare	8
crucial role in	8
a function of	8
can be applied	8
much of the	8
critical for the	8
to ensure that	8
carried out using	8
structures from the	8
number of binding	8
the degradation of	8
in all cases	8
frequency and abundance	8
known about the	8
in the multiple	8
world health organization	8
the search queries	8
the enzymatic activity	8
predicted cleavage site	8
effects of over	8
data not shown	8
the understanding of	8
terminal loop of	8
has recently been	8
in spite of	8
proteins have been	8
the influenza virus	8
from the frad	8
efficiency of the	8
to generate the	8
by the s	8
molecular weight of	8
the genome of	8
using circular dichroism	8
environment of the	8
in conjunction with	8
may not be	8
the results obtained	8
state of the	8
the river alwin	8
involved in a	8
is used for	8
a critical role	8
protein structure prediction	8
in comparison with	8
the differences in	8
protein structure alignment	8
both of the	8
the roles of	8
to this end	8
methods have been	8
the transmembrane domain	8
yet to adopt	8
provide insight into	8
that the p	8
is also a	8
of these two	8
of the disease	8
contacts between the	8
although it is	8
the stop codon	8
the top of	8
and its interaction	8
which is also	8
by the host	8
protein can be	8
in western norway	8
results in a	8
sox cleavage sites	8
relative abundance of	8
plays a key	8
have investigated the	8
h n influenza	8
orf a peptide	8
little is known	8
to the s	8
district medical college	8
from p to	8
in a given	8
j is the	8
to the wild	8
mutations on the	8
are available at	8
top of the	8
glutamate carboxypeptidase ii	8
in close proximity	8
hypothesize that the	8
the conformation of	8
the maturation of	8
implies that the	8
the terminal loop	8
been summarized in	8
was performed using	8
to the formation	8
the protein was	8
of this region	8
transition transversion rate	8
by maximum likelihood	7
plays an important	7
and s a	7
set of protein	7
the proprotein convertases	7
in the transmembrane	7
is not the	7
of the tourism	7
in the cells	7
broad range of	7
of the extracellular	7
the recognition of	7
tool for the	7
receptor and the	7
downstream secondary structure	7
summarized in figure	7
protein interactions and	7
we focus on	7
type and mutant	7
to be used	7
could be useful	7
analysis revealed that	7
this indicates that	7
has been reported	7
and community well	7
a predicted cleavage	7
from frad sites	7
the availability of	7
able to bind	7
proteins from the	7
different from the	7
ray crystal structure	7
domains in the	7
we describe the	7
appear to be	7
in the primary	7
the short peptide	7
described in sect	7
secondary structure elements	7
spike protein of	7
as described previously	7
and effects of	7
b and b	7
the presence or	7
used to detect	7
the united states	7
for the presence	7
rna binding site	7
the results suggest	7
with those of	7
the features of	7
to obtain the	7
composed of a	7
stabilization of the	7
of the glycosylation	7
an understanding of	7
number of sites	7
to increase the	7
final volume of	7
at this position	7
catalytic domain of	7
and determination of	7
of one of	7
with a new	7
here we describe	7
at least three	7
specific cyber threats	7
one of these	7
names of frad	7
gives rise to	7
in presence of	7
computational design of	7
development of the	7
folding and unfolding	7
of the wild	7
in the e	7
about the role	7
the p and	7
determined to be	7
have been successfully	7
of the test	7
the basis for	7
proteolytic sites are	7
to allow the	7
the correlation between	7
the remainder of	7
in this article	7
quality of life	7
accuracy of the	7
should be considered	7
genes involved in	7
at the cleavage	7
has been studied	7
of amyloid fibrils	7
the similarity of	7
tier of analysis	7
have not yet	7
picture of the	7
spearman rank correlation	7
the c terminus	7
the viral rna	7
of the individual	7
was performed in	7
located in a	7
to develop a	7
a multiplicative factor	7
for each protein	7
based on an	7
amino acids with	7
hydrophobic amino acids	7
were subjected to	7
influenza virus hemagglutinin	7
positions of the	7
by nmr spectroscopy	7
to the same	7
of the functional	7
the best of	7
open reading frames	7
wild type and	7
which results in	7
the difference in	7
to probe the	7
a maximum of	7
the enzyme activity	7
also found that	7
evolution of a	7
better understand the	7
in light of	7
with or without	7
and the protein	7
glycans are capable	7
changes in protein	7
for detecting positive	7
review of the	7
results of our	7
is achieved by	7
this is a	7
an overview of	7
the data was	7
important for the	7
to the catalytic	7
in the assembly	7
motif in the	7
binding site contacts	7
action of the	7
order to understand	7
bottom of the	7
except for the	7
is comprised of	7
be useful for	7
enteropeptidase light chain	7
encoded by the	7
was identified as	7
belonging to the	7
with regard to	7
the target proteins	7
that they are	7
the thermal stability	7
server for the	7
van der maarel	7
located on the	7
are in progress	7
of sites under	7
the ribosomal p	7
of the essential	7
cell entry of	7
aut onoma de	7
mechanism by which	7
areas of the	7
features of local	7
an attempt to	7
the cell membrane	7
the combination of	7
also in the	7
studies indicate that	7
showing that the	7
zinc hook domain	7
has been demonstrated	7
has been proposed	7
the p x	7
with the highest	7
between local structures	7
in the catalytic	7
mdi spacers in	7
expressed and purified	7
of the quadrat	7
of the b	7
at the predicted	7
wake forest university	7
to generate a	7
effects on the	7
sequences that were	7
at the mine	7
the arms race	7
in the overlapping	7
community in the	7
center of the	7
log likelihood scores	7
of proteolytic sites	7
that we have	7
resolution structure of	7
of s rrna	7
palmeni and p	7
to estimate the	7
on the ribosome	7
three of the	7
involved in this	7
were located in	7
can be detected	7
and binding of	7
the selective pressure	7
was analyzed by	7
in small island	7
and we have	7
investigation of the	7
in the evolution	7
properties of these	7
a final volume	7
the involvement of	7
in the viral	7
the perch study	7
of column buffer	7
a class of	7
should be noted	7
lead to a	7
acid binding site	7
in the region	7
with pneumonia in	7
traditionally managed hay	7
methods can be	7
is available for	7
are related to	7
would like to	7
of the inhibitor	7
the form of	7
of the sensor	7
of processing at	7
selected sites are	7
order to investigate	7
found to have	7
the antigen concentration	7
to reveal the	7
susceptibility to infection	7
in the form	7
selected sites in	7
was observed for	7
in vitro transcription	7
even in the	7
and amino acid	7
between the protein	7
of the resulting	7
residues that are	7
it is therefore	7
or absence of	7
impact of the	7
of a number	7
the diversity of	7
the h n	7
frameshifting in the	7
isolated from a	7
thought to have	7
even though the	7
the log likelihood	7
a consequence of	7
the catalytic activity	7
the strength of	7
is characterized by	7
were identified by	7
and expression of	7
the findings indicate	7
of protein synthesis	7
mcelroy and pearce	7
with high affinity	7
when compared with	7
a and m	7
leads to the	7
we have designed	7
as described in	7
the description of	7
is formed by	7
of cacybp sip	7
on the same	7
that the l	7
secondary structure and	7
the potential of	7
inhibitors of the	7
in the laboratory	7
supported by grants	7
terminal amino acid	7
proteins that are	7
to either the	7
m and m	7
is known as	7
the v loop	7
is part of	7
targets for the	7
subunits of the	7
at low temperatures	7
of the glycan	7
is not only	7
proteins with a	7
performance of the	7
have been investigated	7
had the highest	7
a comparison of	7
for the two	7
its role in	7
method has been	7
proteolytic activation of	7
proteins based on	7
were confirmed by	7
necrotic cell death	7
of a human	7
a and a	7
processing at the	7
the two proteins	7
a conformational change	7
cut sites that	7
the group of	7
to contribute to	7
sites that had	7
could be due	7
this work is	7
of e protein	7
the sox cleavage	7
and orf b	7
we do not	7
provide valuable information	7
been reported to	7
for prediction of	7
a broad range	7
presence or absence	7
with the p	7
mdi spacers for	7
in this process	7
the state of	7
the usefulness of	7
needs to be	7
it is the	7
dynamic light scattering	7
maximum descent of	7
to have the	7
department of biochemistry	7
of international tourism	7
consists of a	7
a reduction in	7
in the sequence	7
phylogenetic analysis by	7
it will be	7
data were collected	7
cleavage at the	7
of these enzymes	7
the galectin fold	7
details of the	7
can be a	7
terminal region of	7
per site and	7
determined by the	7
functions of the	7
taking into account	7
analysis of these	7
a decrease in	7
carried out in	7
the secretory pathway	7
component of the	7
fauna of a	7
and at the	7
found in both	7
description of the	7
with the aid	7
secondary site binding	7
are widely used	7
a phylogenetic tree	7
of protein folding	7
of the f	7
collection and analysis	7
this type of	7
on the mine	7
diseases such as	7
none of the	7
been associated with	7
using a combination	7
the name of	7
protein is a	7
action of a	7
and molecular dynamics	7
serine protease inhibitors	7
the host plant	7
an intrinsically disordered	7
framework for the	7
helix of the	7
this can be	7
in the different	7
lee et al	7
is synthesized as	7
of the northern	7
as frad sites	7
cov and mers	7
of a highly	7
the solution structure	7
this model is	7
and inhibition of	7
that there are	7
we decided to	7
leads to a	7
in vitro studies	7
of functional sites	7
structural features of	7
in the extracellular	7
in contrast with	7
were introduced into	7
was performed by	7
in a large	7
glycosylation sites in	7
the molecular mechanisms	7
feature of the	7
aim is to	7
contributed to the	7
implications for the	7
of the effect	7
of healthcare facilities	7
of the protease	7
using the same	7
to minimize the	7
health care services	7
the s rrna	7
of the glycans	7
results of this	7
order to find	7
transect frequency per	7
de novo design	7
that the presence	7
impact on the	7
the binding kinetics	7
in the late	7
the prevalence of	7
both in vitro	7
the most prevalent	7
observed that the	7
the immune system	7
the proteolytic site	7
frad sites in	7
seen in figure	7
transcription and translation	7
after h of	7
in the site	7
by furin and	7
is in agreement	7
analysis by maximum	7
identification of the	7
they do not	7
the study was	7
we are currently	7
the results from	7
with each other	7
a cleavage site	7
the fraction of	7
at site and	7
the ligand binding	7
cleaved by furin	7
the human coronavirus	7
is a member	7
distant from the	7
its interactions with	7
a new method	7
the core of	7
bovine serum albumin	7
is expressed in	7
most of these	7
of the virome	7
to form the	7
at specific locations	7
strongly associated with	7
and the role	7
that could be	7
to the n	7
was the first	7
of the heptamer	7
findings indicate that	7
under purifying selection	7
to make the	7
scores for the	7
was observed in	7
sites from the	7
mapping of the	7
the need to	7
in the dimer	7
the association rate	7
in the wild	7
of cleavage sites	7
have the same	7
syndrome coronavirus spike	6
are in agreement	6
were applied to	6
use land cover	6
were analyzed using	6
structure of this	6
sequence and the	6
likely to have	6
to have originated	6
detected most often	6
for the sars	6
are crucial for	6
confined to the	6
the catalytic triad	6
the difference between	6
for the top	6
may be involved	6
for the identification	6
the united nations	6
influenza virus a	6
furin and other	6
by a combination	6
results presented here	6
the proteolytic regulation	6
the modulation of	6
the bottom fauna	6
is needed to	6
was expressed in	6
formed in the	6
are important for	6
kinetic parameters of	6
to search for	6
the ace receptor	6
fraction of the	6
a target for	6
and development of	6
phlebophylla and s	6
the boat conformation	6
regions in the	6
the s ribosome	6
in the lower	6
with the binding	6
research for child	6
to a more	6
of the d	6
higher than that	6
it to be	6
because they are	6
dna and rna	6
early adopter sites	6
we are developing	6
a new model	6
consequence of the	6
the occupancy status	6
to catalyze the	6
possible that the	6
was associated with	6
this method is	6
to participate in	6
were designed to	6
of protein surface	6
health care facilities	6
the cleavage sequences	6
was then used	6
based on our	6
of the reaction	6
available in the	6
in the positive	6
virus and host	6
a distance of	6
as a protein	6
selection in a	6
the native structure	6
a mutant of	6
in less than	6
the relative abundance	6
crystal structures and	6
detected in the	6
remainder of the	6
jones et al	6
such as those	6
of a variety	6
subcellular localization of	6
a hybrid model	6
of the results	6
tourism from a	6
terminal to the	6
c and pol	6
the river coquet	6
in the us	6
modulation of the	6
in an attempt	6
orf a and	6
lower than that	6
are indicated by	6
web pages and	6
in the control	6
secondary and tertiary	6
a new host	6
accessed the curriculum	6
the main protease	6
present study was	6
the catalytic efficiency	6
previously shown that	6
the full length	6
of the domain	6
the determinants of	6
in comparison to	6
binding site is	6
the gene encoding	6
a significant difference	6
the potential for	6
access to healthcare	6
was predicted to	6
the product of	6
the avian na	6
and orf a	6
at the centre	6
is very important	6
from each of	6
by the viral	6
one of which	6
is performed by	6
in the number	6
of the kexin	6
m a in	6
site directed mutagenesis	6
the absence or	6
selection on the	6
have resulted in	6
in human brain	6
as previously reported	6
of dengue virus	6
the decision to	6
of the peptides	6
contribution to the	6
of ebola virus	6
on the right	6
of the gene	6
ability of the	6
cell wall binding	6
of protein aggregation	6
how to remove	6
basis of the	6
the results indicate	6
on amino acid	6
introduced into the	6
immune response to	6
a cluster of	6
it is clear	6
and that this	6
and the active	6
quadrat frequency per	6
used to evaluate	6
aspects of the	6
to reduce the	6
in the americas	6
occupancy status of	6
play a crucial	6
of a given	6
gr and tif	6
the substrate binding	6
growth in the	6
figure a and	6
of h n	6
were obtained from	6
between these two	6
the complement system	6
active site is	6
sites and the	6
a powerful tool	6
only of the	6
the catalytic cysteine	6
the rna polymerase	6
of the codon	6
in a wide	6
a web server	6
and it has	6
was designed to	6
the human brain	6
of both proteins	6
in collaboration with	6
most abundant and	6
simulations were run	6
the response of	6
the mutation of	6
sars and sars	6
the secondary binding	6
processed by furin	6
to min post	6
the gfp mrna	6
based on protein	6
method to predict	6
were in the	6
interpretation of the	6
of adaptive evolution	6
the unfolded state	6
chen et al	6
the positively selected	6
at the surface	6
in the sites	6
trained to identify	6
the reaction of	6
at that site	6
for the second	6
domain and the	6
should not be	6
sites using the	6
have been used	6
the kinetic parameters	6
sequence at the	6
myelin basic protein	6
were excluded from	6
creative commons attribution	6
host cell proteases	6
tested whether the	6