This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-000295-ft5wl70x | Got target? |
| cord-000715-zl1s82yi | ( PDF) Real- time PCR in virology Real- time PCR in clinical microbiology: applications for routine laboratory testing Quality control in nucleic acid testing- where do we stand? |
| cord-000265-llilwq1u | Clinical characteristics of 26 human cases of highly pathogenic avian influenza A( H5N1) virus infection in China Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus Influenza A/ H5N1 virus infection in humans in Cambodia Fatal avian influenza A( H5N1) in a child presenting with diarrhea followed by coma Pathology of fatal human infection associated with avian influenza A H5N1 virus Influenza virus entry and infection require host cell N- linked glycoprotein Fatal outcome of human influenza A( H5N1) is associated with high viral load and hypercytokinemia Re- emergence of fatal human influenza A subtype H5N1 disease Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-000435-2u49b7xo | How can our results be reconciled with previous results which indicated that only the immediately 3 0-adjacent 1- 3 nt were relevant for RT in these viruses? |
| cord-001985-iwfidoer | Are we missing half of the viruses in the ocean? |
| cord-001090-qg2r691d | Diagnostic criteria and microbial and epidemiologic associations Effect of periodontal pathogens on the metatranscriptome of a healthy multispecies biofilm model Metatranscriptomic approach to analyze the functional human gut microbiota Composition of the Vaginal Microbiota in Women of Reproductive Age-Sensitive and Specific Molecular Diagnosis of Bacterial Vaginosis Is Possible? |
| cord-001397-nrq4ncdf | Why is tick- borne encephalitis increasing? |
| cord-001397-nrq4ncdf | an update Internally deleted WNV genomes isolated from exotic birds in New Mexico: function in cells, mosquitoes, and mice Modeling antibody- enhanced Dengue virus infection and disease in mice: protection or pathogenesis? |
| cord-000556-uu1oz2ei | Large gene overlaps in prokaryotic genomes: result of functional constraints or mispredictions? |
| cord-001257-t21l6i3f | Distinct DDX DEAD- box RNA helicases cooperate to modulate the HIV-1 Rev function From promoting to inhibiting: diverse roles of helicases in HIV-1 Replication Viruses and the human DEAD- box helicase DDX3: inhibition or exploitation? |
| cord-001257-t21l6i3f | REN stimulatory for replication? |
| cord-002015-s3tdllby | Lehman N. Spontaneous network formation among cooperative RNA replicators Beta- sheet topology and the relatedness of proteins Are there knots in proteins? |
| cord-002015-s3tdllby | Some new twists Probability of DNA knotting and the effective diameter of the DNA double helix DNA knots reveal a chiral organization of DNA in phage capsids Knotting of a DNA chain during ring closure Absence of knots in known RNA structures To knot or not to knot? |
| cord-000895-z5rdf0mi | Codon usage between genomes is constrained by genome- wide mutational processes Codon usage: mutational bias, translational selection, or both? |
| cord-000895-z5rdf0mi | Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses? |
| cord-000578-jhetyd9t | Thus, can tombusviruses and other small RNA viruses replicate without the use of a helicase or they subvert a cellular helicase(s) to assist their replication? |
| cord-000578-jhetyd9t | Why would TBSV utilize both an RNA chaperone and an RNA helicase? |
| cord-000128-t74b5j2j | Pre- mRNA splicing and human disease Alternative splicing in disease and therapy Alternative splicing in disease Are splicing mutations the most frequent cause of hereditary disease? |
| cord-000128-t74b5j2j | influence of fixative protocols Is VP22 nuclear homing an artifact? |
| cord-000128-t74b5j2j | siRNA effectively inhibits tumor growth in colon adenocarcinoma Cell- penetrating- peptidemediated siRNA lung delivery Cellular delivery in vivo of siRNA- based therapeutics Targeting the lung using siRNA and antisense based oligonucleotides Delivery of short interfering RNA using endosomolytic cellpenetrating peptides TP10, a delivery vector for decoy oligonucleotides targeting the Myc protein Photo inducible RNA interference using cell permeable protein carrier Cellular siRNA delivery mediated by a cell- permeant RNA- binding protein and photoinduced RNA interference Split genes and RNA splicing The spliceosome: the most complex macromolecular machine in the cell? |
| cord-000830-jiy4cp4n | Diagnostic molecular microbiology review Rapid enterovirus molecular testing in cerebrospinal fluid reduces length of hospitalization and duration of antibiotic therapy in children with aseptic meningitis Nucleic acid amplification and related techniques in microbiological diagnosis and epidemiology Molecular detection and quantitative analysis of the entire spectrum of human adenoviruses by a two- reaction real- time PCR assay Typing of human adenoviruses in specimens from immunosupressed patients by PCR- fragment length analysis and real- time quantitative PCR Monitoring of cytomegalovirus reactivation in bone marrow tranplant recipients by real- time PCR Comparison of commercial and in- house real- time PCR assays for quantification of Epstein- Barr virus( EBV) DNA in plasma Cytomegalovirus quantification: where to next in optimising patient management? |
| cord-001655-uqw74ra0 | Presence of neutralizing antibodies against Junin virus( Argentine hemorrhagic fever) in guinea pigs infected with Tacaribe virus Cross- protection in nonhuman primates against Argentine hemorrhagic fever Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest A revision of the system of nomenclature for influenza viruses: a WHO Memorandum The Modern U.S. Reptile Industry Wet markets- a continuing source of severe acute respiratory syndrome and influenza? |
| cord-000881-s90geszi | A structural and primary sequence comparison of the viral RNA- dependent RNA polymerases Stabilization of poliovirus polymerase by NTP binding and fingers- thumb interactions Dynamics: the missing link between structure and function of the viral RNA- dependent RNA polymerase? |
| cord-002746-qn34eyul | The A- rich RNA sequences of HIV-1 pol are important for the synthesis of viral cDNA Various regulatory sequences are deprived of their uniqueness by the universal rule of TA/ CG deficiency and TG/ CT excess Selection against CpG dinucleotides in lentiviral genes: a possible role of methylation in regulation of viral expression Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses? |
| cord-002746-qn34eyul | distinct biological states Circularization of the HIV-1 RNA genome RNA interactions in the 5′ region of the HIV-1 genome Circularization of the HIV-1 genome facilitates strand transfer during reverse transcription Nucleotide composition as a driving force in the evolution of retroviruses What can AIDS virus codon usage tell us? |
| cord-002222-rgqwm3vb | infection in a free- ranging social carnivore, the spotted hyaena( Crocuta crocuta) Does lactation lead to resource allocation trade- offs in the spotted hyaena? |
| cord-000364-ikq38rm1 | authors: Rasmuson, J.; Andersson, C.; Norrman, E.; Haney, M.; Evander, M.; Ahlm, C. title: Time to revise the paradigm of hantavirus syndromes? |
| cord-000372-wzwpyvll | Nevertheless, what might the biological relevance of these events be for a cytoplasmic virus? |
| cord-000372-wzwpyvll | another mechanism for host protein synthesis shutoff? |
| cord-000937-8vk89i4h | A novel DNA virus( TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology TT- virus infection in North American blood donors, patients with fulminant hepatic failure, and cryptogenic cirrhosis TT viruses: oncogenic or tumorsuppressive properties? |
| cord-000937-8vk89i4h | clusters of orthologous genes and reconstruction of viral genome evolution GB virus C replicates in primary T and B lymphocytes GB virus type C/ hepatitis G virus: a non- pathogenic flavivirus associated with prolonged survival in HIV- infected individuals GB virus C: the good boy virus? |
| cord-000804-0hlj6r10 | Is Marburg virus enzootic in Gabon? |
| cord-000804-0hlj6r10 | The morbid anatomy of Marburg virus disease Marburg and Ebola hemorrhagic fevers: does the primary course of infection depend on the accessibility of organ- specific macrophages? |
| cord-000804-0hlj6r10 | Viral hemorrhagic fever- a vascular disease? |
| cord-000981-6vloa2w3 | Toll- like receptor signaling TLR3 in antiviral immunity: Key player or bystander? |
| cord-000293-pc4x5e24 | A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting Progress in antisense technology Morpholino oligos: making sense of antisense? |
| cord-000293-pc4x5e24 | The global structures of a wild- type and poorly functional plant luteoviral mRNA pseudoknot are essentially identical Correlation between mechanical strength of messenger RNA pseudoknots and ribosomal frameshifting Interaction of the HIV-1 frameshift signal with the ribosome Characterization of the mechanical unfolding of RNA pseudoknots Locked nucleic acid oligonucleotides: the next generation of antisense agents? |
| cord-000293-pc4x5e24 | towards clinical reality Antisense technology: a selective tool for gene expression regulation and gene targeting Chemical modification: the key to clinical application of RNA interference? |
| cord-001542-f089bs8r | -beta an alternative treatment for chronic hepatitis C? |
| cord-001542-f089bs8r | Do therapeutic antibodies hold the key to an effective treatment for Ebola hemorrhagic fever? |
| cord-001542-f089bs8r | Early epidemic dynamics of the West African 2014 Ebola outbreak: estimates derived with a simple two- parameter model Filoviruses": a real pandemic threat? |
| cord-001542-f089bs8r | Is β- interferon a promising therapeutic option for the management of hepatitis C? |
| cord-001542-f089bs8r | VP40 be a drug target? |
| cord-003254-yiqdsf9z | ( IFN- beta) expression Is there a twelfth protein- coding gene in the genome of influenza A? |
| cord-003254-yiqdsf9z | An overlapping essential gene in the Potyviridae Evidence for a novel gene associated with human influenza A viruses Translational control in positive strand RNA plant viruses Mutations in the C, D, and V open reading frames of human parainfluenza virus type 3 attenuate replication in rodents and primates Evidence for the recent origin of a bacterial protein- coding, overlapping orphan gene by evolutionary overprinting Mapping overlapping functional elements embedded within the protein- coding regions of RNA viruses Detecting overlapping coding sequences with pairwise alignments Detecting overlapping coding sequences in virus genomes RNA editing in the phosphoprotein gene of the human parainfluenza virus type 3 Analysis of putative ORF3 gene within porcine circovirus type 2 Newcastle disease virus V protein is associated with viral pathogenesis and functions as an alpha interferon antagonist Ribosome footprint profiling of translation throughout the genome Highresolution analysis of coronavirus gene expression by RNA sequencing and ribosome profiling An overlapping proteincoding region in influenza A virus segment 3 modulates the host response Origins of genes:"big bang"or continuous creation? |
| cord-000547-adfigzc1 | Why does Coomassie Brilliant Blue R interact differently with different proteins? |
| cord-001152-v6uc0ijw | Is RNA interference involved in intrinsic antiviral immunity in mammals? |
| cord-002542-f7l4ty2j | A Potential New Human Antiviral Immunostimulatory Defective Viral Genomes from Respiratory Syncytial Virus Promote a Strong Innate Antiviral Response during Infection in Mice and Humans Effects of defective interfering viruses on virus replication and pathogenesis in vitro and in vivo Defective viral genomes arising in vivo provide critical danger signals for the triggering of lung antiviral immunity Engineering of homologous recombination hotspots with AU- rich sequences in brome mosaic virus Identification and manipulation of the molecular determinants influencing poliovirus recombination Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad- spectrum antivirals? |
| cord-002542-f7l4ty2j | An inevitable consequence of an error- prone polymerase? |
| cord-002542-f7l4ty2j | Why do RNA viruses recombine? |
| cord-001829-rwnbxmt4 | or alfa-2a with ribavirin for treatment of hepatitis C infection Deciphering the interleukin 28B variants that better predict response to pegylated interferon- alpha and ribavirin therapy in HCV/ HIV-1 coinfected patients Estimating the net contribution of interleukin-28B variation to spontaneous hepatitis C virus clearance Genome- wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts Analysis of IL28B variants in an Egyptian population defines the 20 kilobases minimal region involved in spontaneous clearance of hepatitis C virus AU- rich elements and associated factors: are there unifying principles? |
| cord-001541-5d64esp4 | The transcription complex of vesicular stomatitis virus Transcription and replication of nonsegmented negative- strand RNA viruses Origins of genes:"big bang"or continuous creation? |
| cord-003187-qdbcdn2j | an emerging flavivirus in Europe Is Usutu virus ready for prime time? |
| cord-002764-px0cz6qn | Noncovalent modulation of the inverse temperature transition and self- assembly of elastin- B- collagen- like peptide bioconjugates Effect of protein fusion on the transition temperature of an environmentally responsive elastin- like polypeptide: a role for surface hydrophobicity? |
| cord-000866-dr2uow4m | What is the biological relevance of the present finding? |
| cord-000866-dr2uow4m | What is the exact contribution of the capping apparatus inhibition to the global mizoribine mechanism of action? |
| cord-001964-iy6qzq58 | A Strategy for Viral Maintenance? |
| cord-001964-iy6qzq58 | How long is it detectable after oral vaccination? |
| cord-003104-9cx1gdze | This principle led Sturtevant to ask,"Why does the mutation rate not evolve to zero?" |
| cord-002994-1zjrunzc | Elife Does adaptation to vertebrate codon usage relate to flavivirus emergence potential? |
| cord-002994-1zjrunzc | In vitro and in vivo evaluation of mutations in the NS region of Lineage 2 West Nile virus associated with neuroinvasiveness in a mammalian model Why do RNA viruses recombine? |
| cord-002994-1zjrunzc | Incorporating chemical modification constraints into a dynamic programming algorithm for prediction of RNA secondary structure Does the choice of nucleotide substitution models matter topologically? |
| cord-003045-r707jl16 | In TCGA Data Using Kraken And Centrifuge Translating RNA sequencing into clinical diagnostics: opportunities and challenges Clinical relevance and public health significance of hepatitis B virus genomic variations Available online at The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data Second- generation PLINK: rising to the challenge of larger and richer datasets VirusSeq: software to identify viruses and their integration sites using next- generation sequencing of human cancer tissue Analysis of Survival Data Next- generation sequencing in clinical virology: discovery of new viruses Human endogenous retrovirus K and cancer: innocent bystander or tumorigenic accomplice? |
| cord-002687-ql6zo8ka | : what should be the goal for new therapies? |
| cord-002687-ql6zo8ka | Novel mechanism of antibodies to hepatitis B virus in blocking viral particle release from cells Processing of X- ray diffraction data collected in oscillation mode Crosstalk between human IgG isotypes and murine effector cells Antiviral monoclonal antibodies: can they be more than simple neutralizing agents? |
| cord-003044-9uqa39j9 | Can we identify host genes in functional classes whose expression depends on viral fitness? |
| cord-003044-9uqa39j9 | To what extent does viral fitness result from specific molecular interactions with host factors and regulatory networks during infection? |
| cord-002673-5a1rfi6k | However, notwithstanding such promising genetic selection opportunities, there are substantial knowledge gaps about the genetic diversity of NNV among Asian grouper hosts: are there many strains within and between regions, perhaps with different virulence so that each region or NNV strain may then require different selection programs, or not? |
| cord-002673-5a1rfi6k | Moreover, is there evidence that NNV strains vary over time? |
| cord-003122-a3f4l6iu | How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin Immunogen design for HIV-1 and influenza Is it possible to develop a"universal"influenza virus vaccine? |
| cord-003122-a3f4l6iu | neuraminidases Neuraminidase receptor binding variants of human influenza A(H3N2) viruses resulting from substitution of aspartic acid 151 in the catalytic site: a role in virus attachment? |
| cord-003505-qr6ukfti | Diagnosis of Parasitic Infections: What's Going On? |
| cord-003130-p2h8p5bm | Red arrow= secretory pathway, blue arrow="? |
| cord-003130-p2h8p5bm | To what extent has climate change contributed to the recent epidemiology of tick- borne diseases? |
| cord-003130-p2h8p5bm | Why is tick- borne encephalitis increasing? |
| cord-003482-f1uvohf0 | Considering the evidence that African bats are naturally susceptible to ZIKV and that little brown bats develop disease, the question emerged: could bats serve as a natural reservoir host for ZIKV in the New World? |
| cord-004827-bnf3mvaf | ( Samuel Roberts Noble Foundation, Ardmore OK) asked"What determines the quasispecies population size? |
| cord-004827-bnf3mvaf | The question arose: how can one recognize if a calculated fold is real? |
| cord-004656-n4h295e5 | This suggests that the developmental changes seen in Angiotensinogen Newbor? |
| cord-003792-v48xeqdz | How important is vertical transmission in mosquitoes for the persistence of dengue? |
| cord-003792-v48xeqdz | How important is vertical transmission of dengue viruses by mosquitoes( Diptera: Culicidae)? |
| cord-002676-zwkl1ywk | How does GP antagonise tetherin? |
| cord-002676-zwkl1ywk | How does NP complete its function? |
| cord-002676-zwkl1ywk | How does VP24 contribute to assembly and budding? |
| cord-002676-zwkl1ywk | How does VP40 associate with the inner leaflet? |
| cord-002676-zwkl1ywk | How does myosin-10 influence the localisation of intrafilopodia motility release? |
| cord-002676-zwkl1ywk | What is the mechanism used to control VP40 oligomerization? |
| cord-007714-n3omlvfl | The nucleolus- a gateway to viral infection? |
| cord-006452-mmdk2xom | administered twice weekly in patients with advanced solid tumors Safety and activity of microRNA- loaded minicells in patients with recurrent malignant pleural mesothelioma: a first- in- man, phase 1, open- label, dose- escalation study Versatile vectors for targeted drug or si/ shRNA cancer therapy Epidemiology and economic burden of asthma New targets for drug development in asthma New therapies for asthma: is there any progress? |
| cord-006452-mmdk2xom | the route to go? |
| cord-004507-ezuyjcxs | Do the ticks of birds at an important migratory hotspot reflect the seasonal dynamics of Ixodes ricinus at the migration initiation site? |
| cord-005281-wy0zk9p8 | CRISPR/ Cas systems Cpf1 is a single RNA- guided endonuclease of a class 2 CRISPR- Cas system How many antiviral small interfering RNAs may be encoded by the mammalian genomes? |
| cord-005281-wy0zk9p8 | Can viruses make us human? |
| cord-005281-wy0zk9p8 | The next genetics revolution? |
| cord-009376-a35a92gh | Different real- time PCR formats compared for the quantitative detection of human cytomegalovirus DNA Human exposure to bovine polyomavirus: a zoonosis? |
| cord-003597-zj3w9ptj | Interferon response to respiratory syncytial virus by bronchial epithelium from children with asthma is inversely correlated with pulmonary function What effect does asthma treatment have on airway remodeling? |
| cord-003597-zj3w9ptj | The BioMart community portal: an innovative alternative to large, centralized data repositories Why weight? |
| cord-003435-ke0az7nf | + regulatory T cells in the human immune system Human dendritic cell subsets: an update Correlates of protection induced by vaccination Cancer immunotherapy via dendritic cells Recombinant snakebite antivenoms: a cost- competitive solution to a neglected tropical disease? |
| cord-003435-ke0az7nf | , what's important? |
| cord-003435-ke0az7nf | Safer and virus- free? |
| cord-003435-ke0az7nf | Where are the advantages of using mRNA for antibody immunotherapies? |
| cord-004509-jkzqmkz6 | : Expect the Unexpected? |
| cord-004509-jkzqmkz6 | Reliability of Real- Time Reverse- Transcription PCR in Clinical Diagnostics: Gold Standard or Substandard? |
| cord-006129-5rog0s98 | Are viral- encoded microRNAs mediating latent HIV-1 infection? |
| cord-006129-5rog0s98 | Current perspectives in microRNAs( miRNA) Host- virus interaction: a new role for microRNAs Silencing viral microRNA as a novel antiviral therapy? |
| cord-009662-ntjngiem | Has delivery been confirmed? |
| cord-009662-ntjngiem | Is the activity checked by a molecular assay? |
| cord-007382-5kb16qb7 | T cells Human deoxyribonucleases STING- dependent cytosolic DNA sensing pathways CRISPR provides acquired resistance against viruses in prokaryotes A developmentally regulated activity that unwinds RNA duplexes An unwinding activity that covalently modifies its double- stranded RNA substrate Toll- like receptor 9 processing: The key event in Toll- like receptor 9 activation? |
| cord-007382-5kb16qb7 | The ribonuclease activity of SAMHD1 is required for HIV-1 restriction Trashing the genome: The role of nucleases during apoptosis Approaching the RNA ligand for RIG- I? |
| cord-005654-n9u2em10 | Could discontinuous transcription be operating in these other cases? |
| cord-005654-n9u2em10 | If Neptune's third satellite l4 is confirmed and proves to be regular and non- commensurate, then QN;? |
| cord-005654-n9u2em10 | In this model, the mini- ex on- derived leader segment of VSG a Reinitiation Mini-exon repeats? |
| cord-005654-n9u2em10 | Is it, for example, a special adaptation which has co- evolved with antigenic variation? |
| cord-005865-7lohh5ty | WHO pandemic influenza draft protocol for rapid response and containment Strategies for containing an emerging influenza pandemic in Southeast Asia Containing pandemic influenza at the source Is China prepared for microbial threats? |
| cord-007621-rapinodd | Prehybridization was performed at 42 °(7 in a solution containing 50%( v/ v) formamide, 5 x SSC, 1× Denhardt's solution, 50 p, g/ ml of denatured salmon sperm DNA, and 0.1% sodium dodecyl sulfate( SDS) for 8- 24 h. Hybridization was carried out at 420(` for 48 h in prehybridization solution containing 10% dextran sulfate, 0.05 mM Na phosphate buffer and denatured? |
| cord-007066-zn10rnrm | Toward early oral cancer detection using gene expression profiling of saliva: a thoroughfare or dead end? |
| cord-007066-zn10rnrm | What are these macromolecules that protect RNA from degradation? |
| cord-007689-0vpp3xdl | Approaching the asymptote? |
| cord-008556-oetrdm8g | Can ACG serve as an initiation codon for protein synthesis in eukaryotic cells? |
| cord-008556-oetrdm8g | How do eucaryotic ribosomes select initiation regions in messenger RNA? |
| cord-008556-oetrdm8g | Poliovirus protease does not mediate cleavage of the 220,000-Da component of the cap binding protein complex Translational control of protein synthesis after infection by VSV VSV mRNA and inhibition of translation of cellular mRNA- is there a P function in VSV? |
| cord-008556-oetrdm8g | What if complementation were to require, in addition to enu, a second minor protein- either a truncated form of enu that initiates a little farther downstream or a small protein encoded in an alternate reading frame? |
| cord-008556-oetrdm8g | What mechanism enables influenza mRNAs to bypass the block that retains host mRNAs in the nucleus? |
| cord-006935-wzz5t3sv | The structural integrity of 2AP~? |
| cord-011794-ejoufvvj | More novel hantaviruses and diversifying reservoir hosts- time for development of reservoirderived cell culture models? |
| cord-009943-fzynh14x | The common cold: Control? |
| cord-010120-mqvm9zn4 | How are mRNA pseudoknots particularly able to promote efficient-1 ribosomal frameshifting? |
| cord-010120-mqvm9zn4 | How do these elements regulate the relative ratios of structural Gag proteins to those having enzymatic functions, i.e. integrase( Int), reverse transcriptase( RT), protease( Pro) and RNAse H? |
| cord-010120-mqvm9zn4 | How then do RNA, 2seudoknots make elongating ribosomes pause in the right place? |
| cord-006826-vnmg0zid | Adv Are weak protein- protein interactions the general rule in capsid assembly? |
| cord-006826-vnmg0zid | Are the CLPs made with longer cargo closed capsids? |
| cord-006826-vnmg0zid | CLP possibly a consequence of cargo length? |
| cord-006826-vnmg0zid | HBV RNA pre- genome encodes specific motifs that mediate interactions with the viral core protein that promote nucleocapsid assembly Hepatitis B virus core protein phosphorylation sites affect capsid stability and transient exposure of the C- terminal Domain Dimerization of the SP1 region of HIV-1 gag induces a helical conformation and association into helical bundles: implications for particle assembly Nucleic acid- independent retrovirus assembly can be driven by dimerization How does your virus grow? |
| cord-006826-vnmg0zid | How do our observations compare to previous work on alphavirus core assembly and assembly models using different spherical viruses? |
| cord-006826-vnmg0zid | Is there a difference between the structures of the CLPs made with 48hp and 48lin as suggested in the hysteresis experiments( figure 2(A))? |
| cord-010977-fwz7chzf | A pilot study Newly expressed SUR1-regulated NC(Ca- ATP) channel mediates cerebral edema after ischemic stroke Sulfonylurea receptor 1 expression in human cerebral infarcts Does inhibiting Sur1 complement rt- PA in cerebral ischemia? |
| cord-010977-fwz7chzf | Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions Very early administration of progesterone for acute traumatic brain injury Embracing failure: What the Phase III progesterone studies can teach about TBI clinical trials Mitochondria- wide association study of common variants in osteoporosis Genetic association studies in cardiovascular diseases: Do we have enough power? |
| cord-000083-3p81yr4n | Between patients with HOMA- IR positive and negative, however, statistically no significant difference was found in terms of age, sex, etiology, Child- Pugh classification, spleen size, TNF-?, |
| cord-000083-3p81yr4n | Do we all failed in addressing socio- economic issues of cancer- sufferers? |
| cord-000083-3p81yr4n | IL-1? |
| cord-000083-3p81yr4n | IL-1? |
| cord-000083-3p81yr4n | IL-1? |
| cord-000083-3p81yr4n | IL-1? |
| cord-000083-3p81yr4n | In additon, we aimed to investigate the relation of insulin resistance in liver cirrhosis with such parameters as age, sex, etiology, Child- Pugh classification, spleen size, TNF-?, IL-1? |
| cord-000083-3p81yr4n | In additon, we aimed to investigate the relation of insulin resistance in liver cirrhosis with such parameters as age, sex, etiology, Child- Pugh classification, spleen size, TNF-?, IL-1? |
| cord-000083-3p81yr4n | In liver cirrhosis group, glucose, insulin, C- peptid, HOMA- IR, TNF-? |
| cord-000083-3p81yr4n | In patients with liver cirrhosis, the levels of glucose, insulin, C- peptid, HOMA- IR, TNF-?, IL-2RES, IL-6, CRP and Hs- CRP increase with respect to normal population. |
| cord-000083-3p81yr4n | In the study, it was also determined that the mechanism of insulin resistance development occurs independent of age, sex, etiology, Child- Pugh classification, spleen size, TNF-?, |
| cord-000083-3p81yr4n | The two groups were compared with each other in terms of glucose, insulin, C- peptid, HOMA- IR, TNF-?, |
| cord-000083-3p81yr4n | These two groups, i.e., HOMA- IR positive and HOMA- IR negative, were compared in terms of age, sex, etiology, Child- Pugh classification, spleen size, TNF-?, |
| cord-001835-0s7ok4uw | 3) Can an exhaustive statistical scan of a large, recent dataset identify new side chain interactions at helix termini? |
| cord-001835-0s7ok4uw | A Promoter or Inhibitor for IAPP aggregation? |
| cord-001835-0s7ok4uw | An empirical framework for binary interactome mapping Estimating the size of the human interactome Coming to peace with protein complexes? |
| cord-001835-0s7ok4uw | Are they essential in carrying out a specific cellular function? |
| cord-001835-0s7ok4uw | But the general effects on traits relevant at atomic/ residue resolutions have been less studied, and one fundamental issue remains unsolved: to what extent are proteins forced into interactions with highly concentrated solutes, and with what direct consequences? |
| cord-001835-0s7ok4uw | Can Bio- functionalities be deciphered from protein sequence information using computational approaches? |
| cord-001835-0s7ok4uw | Can site- directed mutagenesis shed light on the refolding pattern of human glucose 6-phosphate dehydrogenase( G6PD)? |
| cord-001835-0s7ok4uw | Can the structure of a protein( H3.1) depend on the treatment of a solvent medium( explicit vs effective) in a coarse- grained computer simulation? |
| cord-001835-0s7ok4uw | Do they play a regulatory role in controlling the on and off of a certain cellular process? |
| cord-001835-0s7ok4uw | How did enzymes, the catalysts of many crucial cellular processes, achieve this cold adaptation? |
| cord-001835-0s7ok4uw | In a protein engineering context, do we need to take into account the dynamics in order to maximize the fitness and function of the resulting proteins? |
| cord-001835-0s7ok4uw | Is there evolutionary pressure to conserve dynamics? |
| cord-001835-0s7ok4uw | Is this necessary to retain functionality, as it has been suggested? |
| cord-001835-0s7ok4uw | Protein engineering: what's next? |
| cord-001835-0s7ok4uw | Questions under- investigation includes what are the effects of mutations( e.g. b- and g- synuclein), how does the structure of an isolated ASN chain change in presence of many interacting protein chains, and how do they organize over the multiple length scales? |
| cord-001835-0s7ok4uw | To what extent are helix- terminal motifs that include multiple amino acids likely to represent genuine cooperative interactions between side chains, rather than chance alignments? |
| cord-001835-0s7ok4uw | Which particular helix- terminal loop geometries are favored by each side chain interaction? |
| cord-010680-lc1onm53 | Advances in mRNA vaccines for infectious diseases Administration of nucleoside- modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge In vivo gene delivery by nonviral vectors: overcoming hurdles? |
| cord-010680-lc1onm53 | The making of bispecific antibodies Therapeutic antibody discovery in infectious diseases using single- cell analysis Beyond natural antibodies: the power of in vitro display technologies Advances in recombinant antibody manufacturing Developability index: a rapid in silico tool for the screening of antibody aggregation propensity Five computational developability guidelines for therapeutic antibody profiling Industrialization of mAb production technology: the bioprocessing industry at a crossroads Monoclonal antibodies: magic bullets with a hefty price tag Pricing of monoclonal antibody therapies: higher if used for cancer? |
| cord-012909-o6t2srim | A target for cancer vaccines? |
| cord-013176-6ckuya1w | : Is There Sufficient Evidence to Define a Health- Promoting Polyphenol- Rich Dietary Pattern? |
| cord-014397-7b88ycv8 | A sialoglycopeptide from human erythrocytes with receptor- like properties for encephalomyocarditis and influenza viruses Resistance in transgenic tobacco plants expressing a nonstructural gene sequence of tobacco mosaic virus is a consequence of markedly reduced virus replication Does the beta- andrenergic factor receptor function as reovirus receptor? |
| cord-014397-7b88ycv8 | Determinants essential for the transmissible gastroenteritis virus receptor interaction reside within a domain of aminopeptidase N that is distinct from the enzymatic site Molecular characterization of gene- for- gene systems in plant fungus interactions and the application of avirulence genes in control of plant pathogens Risk assessment: do we let history repeat itself? |
| cord-014397-7b88ycv8 | Plant viral resistance Will transgenic crops generate new viruses and new diseases? |
| cord-014397-7b88ycv8 | The mammalian cell- virus relationship Attachment of poliovirus to cultivated cells of primate and nonprimate origin Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily Binding to sialic acids is not an essential step for entry of animal rotaviruses to epithelial cells in culture Genetic exchange between bacteriophage T4 and filamentous fungi? |
| cord-014397-7b88ycv8 | Why did certain mechanisms develop and others not? |
| cord-005147-mvoq9vln | -how do we manage the extreme costs of these products, especially in light of the many unsolved issues with respect to effectiveness? |
| cord-005147-mvoq9vln | -what is the influence of antibody generation on clinical effectiveness? |
| cord-005147-mvoq9vln | -what is the natural history and"point of no return"for subgroups of patients within one LSD's? |
| cord-005147-mvoq9vln | > G;p.?) |
| cord-005147-mvoq9vln | And then: what is early? |
| cord-005147-mvoq9vln | Congenital myopathies and congenital muscular dystrophies: Will genetic testing replace muscle biopsy in the near future? |
| cord-005147-mvoq9vln | Disproportioned short stature and multiple anomalies in a patient with a homozygous PIK3C2A mutation-a new ciliopathy? |
| cord-005147-mvoq9vln | Inherited DNA repair mutations: are they modifiers of BRCA1 and BRCA2 penetrance and age at onset of hereditary breast and ovarian cancer? |
| cord-005147-mvoq9vln | Many unresolved questions exist at this stage, including the following:-what is the natural history and"point of no return"for the different LSD's? |
| cord-005147-mvoq9vln | What is the functional role of these ectopically expressed olfactory receptors? |
| cord-013280-kczj24se | Autophagy, antiviral immunity, and viral countermeasures Autophagy and viruses: Adversaries or allies? |
| cord-013280-kczj24se | I interferon suppression LGP2 synergy with MDA5 in RLR- mediated RNA recognition and antiviral signaling PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2 Innate immune sensor LGP2 is cleaved by the Leader protease of foot- and- mouth disease virus Stress granules and cell signaling: More than just a passing phase? |
| cord-012420-llh22iq2 | : Implications for antiviral strategies Molecular Biology of the Prototype Arenavirus, Lymphocytic Choriomeningitis Virus Lassa virus Z protein is a matrix protein and sufficient for the release of virus- like particles Cytoplasmic tails of bunyavirus Gn glycoproteins- Could they act as matrix protein surrogates? |
| cord-012420-llh22iq2 | Who gets sick, and why? |
| cord-012420-llh22iq2 | Who's interfering with whom? |
| cord-004879-pgyzluwp | A50$ 14- 28 Neutralization rates of TNF- a from eight animal species by a monoclonal antibody against human TNF: implication for receptor action? |
| cord-004879-pgyzluwp | Are these two activities encoded by a single mRNA? |
| cord-004879-pgyzluwp | Do their protein- chemical structure and organisation decipher us certain clues and parts of the path by which they have been selected and derived from a possible primordial reaction centre polypeptide? |
| cord-004879-pgyzluwp | Does the ALEP1 germ- line specific protein have a homologue in the somatic ribosomes? |
| cord-004879-pgyzluwp | However, in the presence of 1000 U/ ml interferon? |
| cord-004879-pgyzluwp | Is membranebound enzyme preferentially associated with a given cellular membrane? |
| cord-004879-pgyzluwp | What is the function of rpS 19? |
| cord-013412-gj443yei | Is antimicrobial resistance a slowly emerging disaster? |
| cord-013412-gj443yei | The G- Quadruplex/ Helicase World as a Potential Antiviral Approach against COVID-19 Targets and tools in antiviral therapy G- quadruplexes in pathogens: A common route to virulence control? |
| cord-013412-gj443yei | Type III Photochemical Mechanism? |
| cord-015527-ph576eji | The role of telomeres in bats'exceptional longevity Longitudinal comparative transcriptomics reveals unique mechanisms underlying extended healthspan in bats Bats and their virome: an important source of emerging viruses capable of infecting humans Mass extinctions, biodiversity and mitochondrial function: are bats'special'as reservoirs for emerging viruses? |
| cord-008588-4eu9v5d3 | An important question not yet satisfactorily answered is: Which distances and torsion angles must be measured with what accuracy to specify a three- dimensional structure for RNA molecules? |
| cord-008588-4eu9v5d3 | Can unpaired nucleotides in all of the secondary structure loop types engage in tertiary pairing? |
| cord-008588-4eu9v5d3 | Do the surrounding base- pairs break to form an internal loop instead of a bulge? |
| cord-008588-4eu9v5d3 | Does a single base bulge that is looped out of the helix create a bend? |
| cord-008588-4eu9v5d3 | Finally, the effects of symmetrical and asymmetrical internal loops on the sugar- phosphate backbone must be explored: Do bends occur at internal loops? |
| cord-008588-4eu9v5d3 | For example, from the cloverleaf secondary structure of tRNA, how would the algorithm know that the junction conformation brings the D loop close to the T loop, but not to the anticodon loop? |
| cord-008588-4eu9v5d3 | How much does a bulge bend or kink the helix? |
| cord-008588-4eu9v5d3 | The main structural questions of interest are:( 1) Does one unpaired base intercalate into the helix, or is it extrahelical, with the base- pairs on either side stacked on each other? |
| cord-008588-4eu9v5d3 | What is the effect of very large bulge loops? |
| cord-013854-wadpugbj | Aberrant firing of replication origins potentially explains intragenic nonrecurrent rearrangements within genes, including the human DMD gene Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology Genome Aggregation Database: gnomAD browser Normal and altered pre- mRNA processing in the DMD gene Long mutant dystrophins and variable phenotypes: evasion of nonsense- mediated decay? |
| cord-013854-wadpugbj | I have dystrophinopathy?: |
| cord-006068-w3if1hns | And does activation of TLRs contribute to the pathogenesis of systemic autoimmune diseases that are IFNα dependent to different extents? |
| cord-006068-w3if1hns | And, if so, to what extent would such therapeutics compromise the protective capacity of the immune system? |
| cord-006068-w3if1hns | And, if these ligands exist, what is their role in health and disease? |
| cord-006068-w3if1hns | Furthermore, mammalian DNA is a very weak immunogen in normal mice, so why are DNAand chromatin- specific antibodies so common in patients and mice with autoimmune disease? |
| cord-006068-w3if1hns | Given the many genetic and environmental factors that are likely to contribute to SLE in humans, will the contribution of TLR9( or TLR7) to disease activity in humans be equally variable? |
| cord-006068-w3if1hns | If endogenous DNA and RNA contribute to the development of systemic autoimmune disease, then are there endogenous ligands for other TLR- family members? |
| cord-006068-w3if1hns | So how does autoantibody specificity relate to disease mechanisms? |
| cord-006068-w3if1hns | Targeting Toll- like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus Lupus erythematosus treated with a combination of quinacrine, hydroxychloroquine, and chloroquine Antagonism of immunostimulatory CpG- oligodeoxynucleotides by quinacrine, chloroquine and structurally related compounds CpG- DNA- specific activation of antigen- presenting cells requires stress kinase activity and is preceded by non- specific endocytosis and endosomal maturation CpG motifs in bacterial DNA activate leukocytes through the pH- dependent generation of reactive oxygen species CpG motifs: the active ingredient in bacterial extracts? |
| cord-006068-w3if1hns | Will blockade of TLR7 and TLR9 prevent and/or ameliorate the clinical features of SLE and related diseases? |
| cord-006068-w3if1hns | effectively? |
| cord-015376-z739ifu5 | Identification of critical determinants on ACE2 for SARS- CoV entry and development of a potent entry inhibitor Blocking of HIV-1 infectivity by a soluble, secreted form of the CD4 antigen Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry Human Coronavirus hCoV-229E enters susceptible cells via the endocytic pathway Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-015376-z739ifu5 | This bioinformatic analysis of drug/ enzyme docking provides interesting insights on the use of HIV-1 protease inhibitors as lead compounds for development of 3Clpro inhibitors Old drugs as lead compounds for a new disease? |
| cord-014908-jys1y0k9 | derivative bearing[ Os(5,6-dimethyl-1,10-phenanthroline)2Cl]2? |
| cord-012552-porty653 | A microRNA cluster in the Fragile- X region expressed during spermatogenesis targets FMR1 Execution of nonsense- mediated mRNA decay: what defines a substrate? |
| cord-012552-porty653 | How might Upf3b influence the selection of this particular set of Olfr genes? |
| cord-012552-porty653 | Our mOSN translome data also allowed us to assess the reciprocal question: does Upf3b influence translation in vivo? |
| cord-013784-zhgjmt2j | ? |
| cord-014685-ihh30q6f | How important is protein exibility for transport through ion channels? |
| cord-014685-ihh30q6f | Should it be the autonomous course or the part of physiology and radiology courses in the problem based learning approach?! |
| cord-014685-ihh30q6f | The consistency in the formations of these conformations makes the design of peptides with alpha, beta? |
| cord-014685-ihh30q6f | a tug- ofwar or coordinated movement? |
| cord-016343-wc3i54fc | ( 2005)? |
| cord-000248-zueoyesj | /ml undergoing radical prostatectomy for prostate cancer? |
| cord-000248-zueoyesj | : What's new?]. |
| cord-000248-zueoyesj | A natural question arises:''Which is the significance of another set, now arbitrarily chosen to be also of the same cardinality( i.e 44 genes) with the complementary behavioural pattern?''We have now listed all the probes according to Diff. |
| cord-000248-zueoyesj | A thermodynamic interpretation of malignancy: do the genes come later? |
| cord-000248-zueoyesj | After observing that Figure 14 shows a correlation of Gleason pattern score with Normalized Shannon Entropy, we asked ourselves:'which are the genes that most positively and negatively correlate with the transitions of Normalized Shannon Entropy?' |
| cord-000248-zueoyesj | Another natural question can be asked: Which is the extra information that we can obtain the by analysing the correlations with the MPR- Statistical Complexity in this case? |
| cord-000248-zueoyesj | Can Entropy and''order''increase together? |
| cord-000248-zueoyesj | Can Shannon Entropy increase while the Normalized Shannon Entropy decrease?'' |
| cord-000248-zueoyesj | Can we quantify the chaos observed in the genome from the increasingly available transcriptional data and relate it to tumour progression?'' |
| cord-000248-zueoyesj | Could changes of key physical parameters for metabolic processes of the cytoplasm and cell's organelles like temperature, volume, pH or electrochemical potentials be also implicated in cancer progression? |
| cord-000248-zueoyesj | Could it be possible that we can track cancer progression by looking at some of these''Maxwell demons''? |
| cord-000248-zueoyesj | Could this be another hallmark for oncosystems indentification? |
| cord-000248-zueoyesj | Does a similar pattern of aquaporin downregulation exist in prostate cancer? |
| cord-000248-zueoyesj | However, in a manuscript entitled''Can Entropy and'order'increase together?'' |
| cord-000248-zueoyesj | In a letter to Peter Guthrie Tait, Maxwell writes about the''demons'':''Is the production of an inequality of temperature their only occupation? |
| cord-000248-zueoyesj | Is aquaporin-3 just a glycerol transporter Physiological roles of glyceroltransporting aquaporins: the aquaglyceroporins A role for mitochondrial aquaporins in cellular life- and- death decisions? |
| cord-000248-zueoyesj | Multifunctional proteins or just regulators of desmosomal adhesion? |
| cord-000248-zueoyesj | Multivariate gene expression analysis reveals functional connectivity changes between normal/ tumoral prostates PSA response signatures-a powerful new prognostic indicator after radiation for prostate cancer? |
| cord-000248-zueoyesj | Osteopontin expression correlates with melanoma invasion Osteopontin in melanocytic lesions- a first step towards invasion? |
| cord-000248-zueoyesj | Possible immunoprotective and angiogenesis- promoting roles for malignant cell- derived prostasomes: a new paradigm for prostatic cancer? |
| cord-000248-zueoyesj | Reactive oxygen species: a breath of life or death? |
| cord-000248-zueoyesj | The rate of lymph node invasion( LNI) in men with PSA values less than 10 ng/ ml Pelvic lymph node irradiation for prostate cancer: who, why, and when? |
| cord-000248-zueoyesj | The story of the discovery of aquaporins: convergent evolution of ideas- but who got there first? |
| cord-000248-zueoyesj | This poses the question: What can we observe while looking at the genes that most positively correlate with the loss of Normalized Shannon Entropy? |
| cord-000248-zueoyesj | What are the consequences if cancer cells are a different type of open system which also operates at a different temperature than a normal cell? |
| cord-000248-zueoyesj | What consequences is this''system''delivering? |
| cord-000248-zueoyesj | What do we learn from molecular dynamics simulations? |
| cord-000248-zueoyesj | What really prevents proton transport through aquaporin? |
| cord-000248-zueoyesj | Which key mechanisms might be impaired? |
| cord-000248-zueoyesj | Which types of mechanisms exist in biological systems, and particularly in individual cells, to control these differential values in key parameters? |
| cord-000248-zueoyesj | Why is it the case that we observe the Normalized Shannon Entropy of the transcriptional profile decreasing with cancer progression when intuitively our average expected surprisal( Shannon Entropy) should increase with progression? |
| cord-000248-zueoyesj | implications for Dunnigan- type familial partial lipodystrophy A- type lamins: guardians of the soma? |
| cord-000248-zueoyesj | nonclassic CCAAT enhancer element binding protein binding site contributes to alpha- methylacyl- CoA racemase expression in prostate cancer Sequence variants of alpha- methylacyl- CoA racemase are associated with prostate cancer risk How often does alphamethylacyl- CoA- racemase contribute to resolving an atypical diagnosis on prostate needle biopsy beyond that provided by basal cell markers? |
| cord-000248-zueoyesj | nuclear mRNA export is coupled to ongoing gene transcription Splicing speckles are not reservoirs of RNA polymerase II, but contain an inactive form, phosphorylated on serine2 residues of the C- terminal domain Regulating gene expression through RNA nuclear retention P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA- dependent manner Dynamics of the mammalian nucleus: can microscopic movements help us to understand our genes? |
| cord-000248-zueoyesj | relationship to melanocyte and keratinocyte carcinogenesis Contribution of p53, p63, and p73 to the developmental diseases and cancer and p63: why do we still need them? |
| cord-000248-zueoyesj | the possibility of exporting entropy'', could it lead to some type of''genetic alterations''? |
| cord-000248-zueoyesj | tumors Plakoglobin is required for effective intermediate filament anchorage to desmosomes Plakophilins- hard work in the desmosome, recreation in the nucleus? |
| cord-017968-17d37a2z | RNA- binding protein Immunoprecipitation from whole- cell extracts Regulation of pri- miRNA processing by the hnRNPlike protein AtGRP7 in Arabidopsis RNA- binding proteins revisited: the emerging Arabidopsis mRNA interactome Whirly proteins as communicators between plant organelles and the nucleus? |
| cord-016309-6mw8okmt | Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with adenine arabinoside, 5-ethyldeoxyuridine, 5-iododeoxyuridine, and phosphonoacetic acid against herpes simplex virus types 1 and 2 Single- chain fragment variable antibody against the capsid protein of bovine immunodeficiency virus and its use in ELISA Cham Bracklein T et al( 2006) Activity of feline interferon- omega after ocular or oral administration in cats as indicated by Mx protein expression in conjunctival and white blood cells High- content screening in infectious diseases History and progress of antiviral drugs: from acyclovir to directacting antiviral agents( DAAs) for Hepatitis C Natural products to drugs: natural product- derived compounds in clinical trials Efficacy, toxicology and clinical applications of ribavirin against virulent RNA viral infections Synthesis and antiviral evaluation of trisubstituted indole N- nucleosides as analogues of 2, 5, 6-trichloro-1-(β- D- ribofuranosyl) benzimidazole( TCRB) Expression and characterization of a recombinant porcinized antibody against the E2 protein of classical swine fever virus Drug repurposing: new treatments for zika virus infection? |
| cord-016309-6mw8okmt | Synthesis and antiviral activity Is AZT/3TC therapy effective against FIV infection or immunopathogenesis? |
| cord-015871-1tuf4zxi | When are observational studies as credible as randomised trials? |
| cord-015871-1tuf4zxi | Wherefore interferon? |
| cord-015871-1tuf4zxi | Yet, despite this effect, why does CCHFV still run its devastating course? |
| cord-004534-jqm1hxps | -Single molecule biophysics- Is there a specific erythrocyte membrane receptor for fibrinogen? |
| cord-004534-jqm1hxps | A generalized quantitative FRAP method with no restriction on the size of the photobleached area Heterochromatin protein 1 in DNA damage response-recruitment or dissociation from repair sites? |
| cord-004534-jqm1hxps | Application of the methodology to binding of various aromatic drugs with DNA provides an answer to the question'What forces are the main contributors to the stabilization of aromatic ligand- DNA complexes'? |
| cord-004534-jqm1hxps | Do retinal rod outer segments carry out oxydative phosphorylation? |
| cord-004534-jqm1hxps | Does the lysosomal membrane need triglycerides? |
| cord-004534-jqm1hxps | What about the force? |
| cord-004534-jqm1hxps | pN. Pushing on microtubules: dominant spindle centering mechanism in C. elegans embryo? |
| cord-017181-ywz6w2po | Structure Distribution- Is the equilibrium ratio between minimum free energy( mfe) and suboptimal structures as expected? |
| cord-017181-ywz6w2po | Structure Refolding- Are molecules able to refold from suboptimal to more stable structural conformations? |
| cord-017181-ywz6w2po | Three different types of experiments were done: Native Structure- Correlates the majority of formed structures with the native structure after sufficient long simulation time? |
| cord-018944-du42ho11 | do we stand? |
| cord-015933-x5cq4k4x | -= niet werkzaam;? |
| cord-015933-x5cq4k4x | : heeft de patiënt met hoge koorts die net terug is uit de tropen malaria of niet, is er bij een kind met hoofdpijn en koorts sprake van een hersenvliesontsteking? |
| cord-015933-x5cq4k4x | maakt hij een zieke indruk of is er sprake van malaise, is de patiënt alert of juist verward en minder goed aanspreekbaar? |
| cord-015850-ef6svn8f | A compromise solution to the introns- early versus introns- late debate? |
| cord-015850-ef6svn8f | The evolution of spliceosomal introns: Patterns, puzzles and progress Genes in pieces: Were they ever together? |
| cord-015850-ef6svn8f | What kind of the relationship exists between the genome size and mutation rates? |
| cord-015850-ef6svn8f | Why genes in pieces? |
| cord-016313-n4ewq0pt | Neuroprotective effect of combined hypoxia- induced VEGF and bone marrowderived mesenchymal stem cell treatment Complete knockdown of CCR5 by lentiviral vector- expressed siRNAs and protection of transgenic macrophages against HIV-1 infection Speci fi c transduction of HIV- susceptible cells for CCR5 knockdown and resistance to HIV infection: a novel method for targeted gene therapy and intracellular immunization Stem cells and reprogramming: breaking the epigenetic barrier? |
| cord-016313-n4ewq0pt | TGF{beta}/ TNF{alpha}-mediated epithelial- mesenchymal transition generates breast cancer stem cells with a claudin- low phenotype Genetically engineered mesenchymal stem cells: applications in spine therapy Hyaluronan and mesenchymal stem cells: from germ layer to cartilage and bone Notch signaling as gatekeeper of rat acinar- to- beta- cell conversion in vitro Transplantation of human bone marrow- derived mesenchymal stem cells promotes Will there be a live- attenuated HIV vaccine available for human safety trials by the year 2000? |
| cord-016293-pyb00pt5 | : Is There Ample Evidence? |
| cord-016293-pyb00pt5 | According to anecdotal evidence when visiting his namesake centre, Sanger asked:"What does this machine do then?""Dideoxy sequencing"came the reply, to which Fred retorted:"Have n't they come up with anything better yet?" |
| cord-016293-pyb00pt5 | According to anecdotal evidence when visiting his namesake centre, Sanger asked:"What does this machine do then?""Dideoxy sequencing"came the reply, to which Fred retorted:"Have n't they come up with anything better yet?" |
| cord-016293-pyb00pt5 | Issues of justice and resource allocation also have been raised: In a time of strain on our health care system, can we afford such expensive therapy? |
| cord-016293-pyb00pt5 | That finding led plant pathologist Roger Beachy, then at Washington University in Saint Louis, to wonder exactly how such"cross- protection"worked-did part of the virus prompt it? |
| cord-016293-pyb00pt5 | When Steve Fodor was asked in 2003"How do you really take the Human genome sequence and transform it into knowledge?" |
| cord-016293-pyb00pt5 | Who should receive gene therapy? |
| cord-020969-lh2ergpm | A look to future directions in gene therapy research for monogenic diseases Update on adenovirus and its vectors Herpes simplex virus 1( HSV-1) for cancer treatment Virus vectors and their applications The use of oncolytic vaccinia viruses in the treatment of cancer: A new role for an old ally? |
| cord-020969-lh2ergpm | In addition, the expression needs to continue for the life of the patient, which means either a very stable( integrated?) |
| cord-019076-4qu9j953 | 2 lineage Coronavirus mRNA synthesis involves fusion of non- contiguous sequences Genetic analysis of Murine hepatitis virus nsp4 in virus replication Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10 Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain- like protease? |
| cord-022084-hap7flng | The Argentinian experience Regional perspectives on influenza surveillance in South America Clinical and epidemiologic importance of influenza A viruses resistant to amantadine and rimantadine Pandemic influenza: Is an antiviral response realistic? |
| cord-016808-gy8d8285 | , i.e., is there a single evolutionary tree or branch of viruses? |
| cord-016808-gy8d8285 | Do viruses form lineages across different domains of life? |
| cord-016808-gy8d8285 | Here a virus, there a virus, everywhere the same virus? |
| cord-016808-gy8d8285 | In other words, is there a place(s) for viruses on universal trees of life proposed for its three kingdoms, Archea, Eubacteria, and Eukarya? |
| cord-016808-gy8d8285 | Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: A hypothesis for the origin of cellular domain Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes Functional and genetic plasticities of the poliovirus genome: Quasi- infectious RNAs modified in the 5-untranslated region yield a variety of pseudorevertants Nonreplicative RNA recombination in poliovirus Nonreplicative homologous RNA recombination: Promiscuous joining of RNA pieces? |
| cord-016808-gy8d8285 | To what extent is the Muller's ratchet inevitable and irreversible? |
| cord-016808-gy8d8285 | What are relationships between viruses and cellular organisms? |
| cord-016808-gy8d8285 | What does then force them to evolve and to form new species and genera? |
| cord-016808-gy8d8285 | how does virus X remain virus X? |
| cord-018437-yjvwa1ot | The size and conformation of Kaposi's sarcoma- associated herpesvirus( human herpesvirus 8) DNA in infected cells and virions Characterization of a novel coronavirus associated with severe acute respiratory syndrome Nucleotide sequence of the Kaposi sarcoma- associated herpesvirus( HHV8) Human bocavirus: passenger or pathogen in acute respiratory tract infections? |
| cord-018437-yjvwa1ot | What does virus evolution tell us about virus origins? |
| cord-017297-q3qtgrfc | A ring- opening mechanism for DNA binding in the central channel of the T7 helicase- primase protein Polypyrimidine- tract- binding protein is a component of the HCV RNA replication complex and necessary for RNA synthesis Helicase inhibition by anthracycline anticancer agents Specific interaction of hepatitis C virus protease/ helicase NS3 with the 3-terminal sequences of viral positive- and negative- strand RNA Host defense, viruses and apoptosis Opening of nucleic- acid double strands by helicases: active versus passive opening Helicases: a unifying structural theme? |
| cord-017297-q3qtgrfc | Does NTP binding alter the enzyme's affinity for nucleic- acid binding? |
| cord-017297-q3qtgrfc | Does the enzyme interact with only one strand of the nucleic acid or both? |
| cord-017297-q3qtgrfc | N7-chloroethyl- guanosine N9-chloroethyl- guanosine Competitive activation of helicase Feedback inhibition by ssNA? |
| cord-017297-q3qtgrfc | Why are these interactions with the cellular factors important? |
| cord-017297-q3qtgrfc | binding by the enzyme could help answer questions like: does the enzyme require a single- stranded region to initiate unwinding? |
| cord-017297-q3qtgrfc | the case of hepatitis C Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen Mechanochemistry of t7 DNA helicase Use of an in vitro model and yeast two- hybrid system to investigate the pathogenesis of hepatitis C Quick guide: DEAD- box proteins Are DEAD- box proteins becoming respectable helicases? |
| cord-016538-4og05fuo | Are there aspects of virus- host interactions that are unique to woody and perennial plants compared to annual herbaceous plants? |
| cord-017732-1pwa6zsk | Why would some viruses use frameshifting to produce a truncated version of the RdRp( those with ORF 3), while others use frameshifting to produce the entire RdRp( those with ORF 2b)? |
| cord-017732-1pwa6zsk | p33 reveals a peroxisome- to- endoplasmic reticulum sorting pathway Sobemoviruses possess a common CfMV- like genomic organization Complete nucleotide sequence and genome organization of pineapple mealybug wilt- associated virus-1 Barley yellow dwarf virus: Luteoviridae or Tombusviridae? |
| cord-016652-x8t3lf1x | I rex- encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA Identification of nucleophosmin/ B23, an acidic nucleolar protein, as a stimulatory factor for in vitro replication of adenovirus DNA complexed with viral basic core proteins Induction of apoptosis by viruses: what role does the nucleolus play? |
| cord-016652-x8t3lf1x | the nucleolus-a gateway to viral infection? |
| cord-018164-h5k1zsyg | Are Viruses Alive? |
| cord-018164-h5k1zsyg | How Are Viruses Spread? |
| cord-018164-h5k1zsyg | Is a bean seed alive? |
| cord-018164-h5k1zsyg | Were these genes derived from the host cell since they mimic host functions and interfere with these functions, or were they acquired by the host eons ago from the virus? |
| cord-018164-h5k1zsyg | What Is a Virus? |
| cord-018164-h5k1zsyg | Where did those mimicking genes come from? |
| cord-019051-gtruu1op | Antibody response and protective effect against acute respiratory disease due to adenovirus type 7 A newly discovered human pneumovirus isolated from young children with respiratory tract disease Human metapneumovirus International Committee on Taxonomy of Viruses Characterization of human metapneumoviruses isolated from patients in North America Global genetic diversity of human metapneumovirus fusion gene Use of the P gene to genotype human metapneumovirus identifies 4 viral subtypes Analysis of the genomic sequence of a human metapneumovirus Respiratory syncytial virus and parainfluenzavirus Individual contributions of the human metapneumovirus F, G, and SH surface glycoproteins to the induction of neutralizing antibodies and protective immunity Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children Detection of severe human metapneumovirus infection by real- time polymerase chain reaction and histopathological assessment Human metapneumovirus infections in hospitalized children Brief communication: Fatal human metapneumovirus infection in stem- cell transplant recipients Human metapneumovirus Perspective on the host response to human metapneumovirus infection: What can we learn from respiratory syncytial virus infections? |
| cord-014462-11ggaqf1 | Both ATP and GTP were utilized as phosporyl donors and Mn 2? |
| cord-014462-11ggaqf1 | Cut off was calculated as Mean negative control? |
| cord-014462-11ggaqf1 | FMDV P1- 3CD''O''vaccine gene constructs in pCDNA3.1? entrapped by the nanoparticles was prepared by using different molarity of calcium chloride and disodium hydrogen orthophosphate. |
| cord-014462-11ggaqf1 | Helicase activity of NSs was absolutely dependent on ATP and Mg 2? |
| cord-014462-11ggaqf1 | How do Indian journals perform in Maintaining quality? |
| cord-014462-11ggaqf1 | How do motivate the scientists to improve their scientific output? |
| cord-014462-11ggaqf1 | How to motivate the scientists to improve their scientific output? |
| cord-014462-11ggaqf1 | In this regard, rNSs is a unique enzyme which does not have the canonical helicase motifs but can catalyze dsDNA/ dsRNA unwinding in an ATP and Mg 2? |
| cord-014462-11ggaqf1 | Should we compare the growth of Indian science with other developed countries? |
| cord-014462-11ggaqf1 | What ails Indian Science? |
| cord-014462-11ggaqf1 | What criteria should be adopted to judge the quality and standard of scientific research? |
| cord-018724-ss8x2g3b | How does the genome structure and lifestyle of a virus affect its population variation? |
| cord-018724-ss8x2g3b | Lifestyles of plant viruses Persistent plant viruses: molecular hitchhikers or epigenetic elements? |
| cord-018724-ss8x2g3b | The remarkable evolutionary history of endornaviruses Plant virus metagenomics: advances in virus discovery Metavir 2: new tools for viral metagnome comparison and assembled virome analysis The role of viruses in biological invasions: friend or foe? |
| cord-023208-w99gc5nx | Are aza- β3 amino acids γ- turn mimetics? |
| cord-023208-w99gc5nx | These cells were multilayered on day-3 and expressed various keratinocyte markers, including cytokeratin-1, involculin, and laminin? |
| cord-016499-5iqpl23p | Antimicrobials for acute otitis media? |
| cord-016499-5iqpl23p | Do rhinoviruses reduce the probability of viral codetection during acute respiratory tract infections? |
| cord-016499-5iqpl23p | Human major group rhinoviruses downmodulate the accessory function of monocytes by inducing IL-10 Rhinovirus- induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness Nasal- secretion leukocyte populations determined by fl ow cytometry during acute rhinovirus infection Expression of intercellular adhesion molecule-1( ICAM-1) in nasal epithelial cells of atopic subjects: a mechanism for increased rhinovirus infection? |
| cord-016499-5iqpl23p | Infl uenza vaccination in the prevention of acute otitis media in children Effi cacy of a pneumococcal conjugate vaccine against acute otitis media Rhinovirus in acute otitis media Temporal relationships between colds, upper respiratory viruses detected by polymerase chain reaction, and otitis media in young children followed through a typical cold season Presence of viral nucleic acids in the middle ear: acute otitis media pathogen or bystander? |
| cord-016499-5iqpl23p | Is acute otitis media a treatable disease? |
| cord-016499-5iqpl23p | So, what do cohort studies, supported by comprehensive PCR- based testing, tell us about asymptomatic virus infections? |
| cord-016499-5iqpl23p | The cold case: Are rhinoviruses perfectly adapted pathogens? |
| cord-016499-5iqpl23p | The common cold: control? |
| cord-016499-5iqpl23p | The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis Rhinovirus infections of children in hospital; isolation of three possibly new rhinovirus serotypes Do rhinoviruses reduce the probability of viral co- detection during acute respiratory tract infections? |
| cord-016499-5iqpl23p | This feature raises an issue: did the use of older subjects in many common cold studies underplay the pathogenic potential of the HRVs because protective or partially cross- protective antibodies moderated the impact of infection? |
| cord-016499-5iqpl23p | human rhinovirus type 17 Antigenic variation of rhinovirus type 22 Isolation of rhinovirus intertypes related to either rhinoviruses 12 and 78 or 36 and 58 Is a rhinovirus vaccine possible? |
| cord-020235-stcrozdw | Are the sites of insertion of viral DNA specific? 2. |
| cord-020235-stcrozdw | What type of recombinatorial events occur in viral DNA integration? |
| cord-025181-eg108wcd | But, type I interferon are vital for CD4? |
| cord-025181-eg108wcd | and CD8? |
| cord-022336-zqnczjpp | Circular RNAs: relics of precellular evolution? |
| cord-022336-zqnczjpp | viroids escaped introns? |
| cord-016095-jop2rx61 | What can teaching, ex cathedra, do to guide the researcher? cord-016095-jop2rx61 , Stanislas DEHAENE( b. 1965), Daniel DENNETT( b. 1942) and others, that thought is not transcendent, and that it is intrinsically dependent on the brain, which is considered to be a neurochemical system, and thus look for the secret of the individuation of the human being in brain information storage mechanisms with retrocontrol loops associated with subtle neuron architectures, or, in short, refer to a sort of TURING machine? cord-016095-jop2rx61 Are the stakes involved in a particular experiment, in terms of the acquisition of new knowledge, worth the suffering of an animal used in that experiment? cord-016095-jop2rx61 At a scientific meeting held in Sheffield, England, in January of 2005 63, with the theme Systems biology: will it work?, an argumentative discussion of the advantages as well as the disadvantages of an integrated, mathematized biology was useful in that it included a reminder that most of the parameters used insystems biology"come from studies that are carried out in vitro on purified enzymes, and that it is not sufficient to know the value of the Michaelian parameters( V max and K m) in order to reach biological reality. |
| cord-016095-jop2rx61 | At what stage of embryo development is it possible to remove ES cells for experimental purposes? |
| cord-016095-jop2rx61 | How can the sum of the scattered experimental data that we have concerning the catalytic capabilities of a multitude of enzymes of cellular origin be integrated into the operation of a cell? |
| cord-016095-jop2rx61 | How can we envisage the gene- enzyme relationship according to current evidence concerning the complexity of the genetic message? |
| cord-016095-jop2rx61 | How could this be true if the teaching faculty did not itself participate in scientific creation? |
| cord-016095-jop2rx61 | In a text entitled Why genetic engineering should continue its battle 31, James WATSON writes of his confusion when faced with a choice that is likely to become more and more insistent over the years:"Dare we be entrusted with improving on the results of several million years of Darwinian natural selection? |
| cord-016095-jop2rx61 | In his What is Bioethics? |
| cord-016095-jop2rx61 | Innumerable cargoes have already reached port, but what will be the destiny of this precious merchandise? |
| cord-016095-jop2rx61 | Is it not necessary to ensure that the experimental protocol is well- documented, that it is not redundant, or even that it has been the subject of previous studies carried out on cells in culture? |
| cord-016095-jop2rx61 | Should"systems biology"be regarded as a resurgence of a physiology that has been somewhat neglected over the last few decades, but has been reinvigorated by a salutary hybridization of biologists and model- makers? |
| cord-016095-jop2rx61 | This example highlights a harrowing ethical dilemma: should we not treat a patient whose illness is likely to be fatal, or attempt a therapy that may save the patient, without having any formal assurance of its success? |
| cord-016095-jop2rx61 | With such an innovation, an unexpected field of exploration has opened up to research in domains as far apart as pharmacology and the science of evolution, giving rise to burning questions: could such non- natural proteins have therapeutic properties? |
| cord-016095-jop2rx61 | could they give a selective advantage to the organisms that host them? |
| cord-016095-jop2rx61 | or do the human germ cells represent on the contrary Rubicons that geneticists will never dare to cross? |
| cord-023120-jcgf2401 | Filled-s represent mWA8 and pro&? |
| cord-023120-jcgf2401 | In addition to these patterns, we&? |
| cord-023120-jcgf2401 | both fragments are rich in hydrophobic amino acids, but? |
| cord-023120-jcgf2401 | events? |
| cord-033692-txfuuu7d | : over 100 M website views per year Ready to submit your research? |
| cord-035067-ic843wr9 | title: COVID-19 and the gastrointestinal tract: what do we already know? |
| cord-001521-l36f1gp7 | ( H1N1) 2009 viruses Pandemic A(H1N1)2009 influenza virus detection by real- time RT- PCR: is viral quantification useful? |
| cord-001521-l36f1gp7 | ( iv) What are the epidemiologic and logistical factors that determine the demand- supply balance of passive immunotherapy? |
| cord-001521-l36f1gp7 | 4?? |
| cord-001521-l36f1gp7 | 4?? |
| cord-001521-l36f1gp7 | 4??? |
| cord-001521-l36f1gp7 | 4??? |
| cord-001521-l36f1gp7 | 4??? |
| cord-001521-l36f1gp7 | ? |
| cord-001521-l36f1gp7 | A quantitative risk assessment of exposure to adventitious agents in a cell culture- derived subunit influenza vaccine John's Hopkins Bloomberg School of Public Health Design of an automated laboratory for high- throughput influenza surveillance Human influenza surveillance: the demand to expand Influenza: an emerging disease Avian- to- human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics Proinflammatory cytokine responses induced by influenza A( H5N1) viruses in primary human alveolar and bronchial epithelial cells Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-001521-l36f1gp7 | Consequently, the more important question is''why did children live?'' |
| cord-001521-l36f1gp7 | Ever since, influenza virologists have sought to answer the question''why did young adults die?''by defining the molecular characteristics of the 1918 virus that were responsible for its virulence. |
| cord-001521-l36f1gp7 | H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment? |
| cord-001521-l36f1gp7 | H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment? |
| cord-001521-l36f1gp7 | H5N1 virus Evidence of a cross- protective immune response to influenza A in the cotton rat model Heterosubtypic immunity to influenza A virus: where do we stand? |
| cord-001521-l36f1gp7 | H9N2 influenza A viruses from poultry in Asia have human virus- like receptor specificity Characterization of H9 subtype influenza viruses from the ducks of southern China: a candidate for the next influenza pandemic in humans? |
| cord-001521-l36f1gp7 | H9N2 influenza A viruses from quail in southern China Characterization of the pathogenicity of members of the newly established H9N2 influenza virus lineages in Asia Sequence analysis of the hemagglutinin gene of H9N2 Korean avian influenza viruses and assessment of the pathogenic potential of isolate MS96 Molecular characterization of H9N2 influenza viruses: were they the donors of the''internal''genes of H5N1 viruses in Hong Kong? |
| cord-001521-l36f1gp7 | How does CS-8958 move from the cell membrane to ER ⁄ Golgi? |
| cord-001521-l36f1gp7 | How many severe cases can be offered passive immunotherapy? |
| cord-001521-l36f1gp7 | In the Control of Epidemic and Pandemic Influenza 12- 13 Characterization of an influenza A H5N2 reassortant as a candidate for live- attenuated and inactivated vaccines against highly pathogenic H5N1 viruses with pandemic potential Are there alternative avian influenza viruses for generation of stable attenuated avian- human influenza A reassortant viruses? |
| cord-001521-l36f1gp7 | In vitro and in vivo assay systems for study of influenza virus inhibitors New low- viscosity overlay medium for viral plaque assays Antibacterial and antifungal activities of Cistus incanus and C. monspeliensis leaf extracts Flavan-3-ols and proanthocyanidins from Cistus incanus Inhibition of the infectivity of influenza virus by tea polyphenols Attenuation of inducible respiratory immune responses by oseltamivir treatment in mice infected with influenza A virus Anti- inflammatory activity of macrolides: a new therapeutic potential? |
| cord-001521-l36f1gp7 | Is laninamivir indeed trapped inside ER ⁄ Golgi, and does it make a complex with NA in mice? |
| cord-001521-l36f1gp7 | New technologies for meeting the global demand for pandemic vaccines Confronting the next influenza pandemic with inexpensive generic agents: can it be done? |
| cord-001521-l36f1gp7 | Novel type II transmembrane serine proteases, MSPL and TMPRSS13, proteolytically activate membrane fusion activity of hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication Is virulence of H5N2 influenza viruses in chickens associated with loss of carbohydrate from the hemagglutinin? |
| cord-001521-l36f1gp7 | Pandemic Influenza Preparedness and Response Prophylaxis or treatment? |
| cord-001521-l36f1gp7 | Qué podemos decir ahora? |
| cord-001521-l36f1gp7 | RT- PCR technique for profiling human cytokines, based on external RNA standards, readily automatable for clinical use Role of hypercytokinemia in NF- kap- paB p50 deficient mice after H5N1 influenza A virus infection Developing new antiviral agents for influenza treatment: what does the future hold? |
| cord-001521-l36f1gp7 | The average daily passenger number is 2489 based on the 2009 Annual Statistical Report on Tourism, Tourism Bureau, Taiwan( http://admin.taiwan.net.tw/english/statistics/year.asp? relno=61). |
| cord-001521-l36f1gp7 | The protein- protein interaction map of Helicobacter pylori Development of a real- time RT- PCR for the detection of Swine- lineage Influenza A( H1N1) virus infections Long- term storage and recovery of buccal cell DNA from treated cards Pandemic A(H1N1)2009 influenza virus detection by real time RT- PCR: is viral quantification useful? |
| cord-001521-l36f1gp7 | The role of influenza virus gene constellation and viral morphology on cytokine induction, pathogenesis, and viral virulence Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-001521-l36f1gp7 | These observations raise the following question: could the host response be modified so patients with severe seasonal and pandemic influenza might have a better chance of surviving? |
| cord-001521-l36f1gp7 | WHO manual on animal influenza diagnosis and surveillance Antigenic characterization of influenza B virus with a new microneutralisation assay: comparison to haemagglutination and sequence analysis Seroprotection rate, meanfold increase, seroconversion rate: which parameter adequately expresses seroresponse to influenza vaccination? |
| cord-001521-l36f1gp7 | Was bacterial pneumonia the predominant cause of death in the 1918- 1919 influenza pandemic? |
| cord-001521-l36f1gp7 | What are the ratelimiting factors in the supply of passive immunotherapy? |
| cord-001521-l36f1gp7 | What is the optimal therapy for patients with H5N1 influenza Meta- analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? |
| cord-001521-l36f1gp7 | What percentage of convalescent individuals( donor percentage) is needed in order for the program to significantly reduce pandemic mortality? |
| cord-001521-l36f1gp7 | World Health Organization WHO outbreak communications guidelines, Geneva: World Health Organization Characterization of H9 subtype influenza viruses from the ducks of southern China: a candidate for the next influenza pandemic in humans? |
| cord-001521-l36f1gp7 | a mechanism for the unusual severity of human disease? |
| cord-001521-l36f1gp7 | did the 2009'swine- origin'influenza A virus( H1N1) emerge? |
| cord-001521-l36f1gp7 | human to pig transmission in Norway? |
| cord-001521-l36f1gp7 | viruses due to substitution of aspartic acid 151 in the catalytic site-role in virus attachment? |
| cord-021568-tdfn6up8 | First, is the infectious agent that leads to TSE PrP Sc itself or is it another entity, such as a virus? |
| cord-021568-tdfn6up8 | How is it that a single, fairly small protein can take up so many different conformations and that each can induce the production of more protein having the same conformation? |
| cord-021568-tdfn6up8 | Second, does PrP Sc, or some other modified form of PrP, cause the symptoms of the disease, or is it simply a side effect of the disease process? |
| cord-021568-tdfn6up8 | Thus, in terms of the protein- only model, PrP Sc might induce the conversion of PrP c to PrP Sc in cells in Peyer's patches, which then spreads via lymphatic tissue to peripheral nerves by sequential conversion of PrP. If PrP Sc can transmit the disease to a new susceptible host, how is it formed in the first place? |
| cord-021568-tdfn6up8 | the noncoding genomes Sequencing of peach latent mosaic viroid variants from nine North American peach cultivars shows that this RNA folds into a complex secondary structure Hepatitis Delta RNA editing in hepatitis delta virus genotype III requires a branched double- hairpin RNA structure Rolling circle replication of hepatitis delta virus RNA is carried out by two different cellular RNA polymerases Hepatitis delta virus: the molecular basis of laboratory diagnosis Hepatitis delta virus RNA editing is highly specific for amber/ W site and is suppressed by hepatitis delta antigen Hepatitis Delta Virus Chapter Prions and Prion Diseases Transmission dynamics and epidemiology of BSE in British cattle Prions in skeletal muscles of deer with chronic wasting disease What went wrong in BSE? |
| cord-018017-c8myq6bi | If infections are the greatest threat to human life, they should be critical drivers of evolution? |
| cord-018017-c8myq6bi | In fact, why study anything that is not the most highly impactful area? |
| cord-018017-c8myq6bi | Most prominent was, why study an area of science that has no significant impact? |
| cord-018017-c8myq6bi | On which disease should we focus? |
| cord-018017-c8myq6bi | This question demands a definition, what constitutes high impact? |
| cord-018017-c8myq6bi | What presents the greatest threat to human life today? |
| cord-018017-c8myq6bi | Why not? |
| cord-023724-5at0rhqk | ( Long- term) pathogenic consequences? |
| cord-023724-5at0rhqk | A high proportion of the human population has already been vaccinated- lifelong protection may result in poor response to recombinant vaccines(?). |
| cord-023724-5at0rhqk | Difficult to grow to high titer and purify for direct administration( patient cells must be cultured in vitro); can not infect nondividing cells- most somatic cells( except lentiviruses?); insertional mutagenesis/ activation of cellular oncogenes. |
| cord-023724-5at0rhqk | How do CRISPRs work? |
| cord-023724-5at0rhqk | How do plant viruses induce disease? |
| cord-023724-5at0rhqk | How do viruses avoid inhibition by endogenous cellular microRNAs? |
| cord-023724-5at0rhqk | Integrate into cell genome, giving long- lasting( lifelong?) |
| cord-023724-5at0rhqk | So how do bacteria survive against this constant onslaught? |
| cord-023724-5at0rhqk | So who( apart from bacteria) cares about CRISPRs? |
| cord-017764-h1w9gbxk | An Inhibitor of the Mathematical modeling of HCV infection: what can it teach us in the era of direct- acting antiviral agents? |
| cord-017764-h1w9gbxk | How were new medicines discovered? |
| cord-017764-h1w9gbxk | Impact of highthroughput screening on biomedical research Cell- based assays to identify inhibitors of viral disease Anti- infectives: can cellular screening deliver? |
| cord-027865-p1epjn51 | ( FKHR) gene break- apart by fluorescence in situ hybridization in formalin- fixed, paraffin- embedded alveolar rhabdomyosarcomas and its clinicopathologic correlation In situ hybridization: a review of methodologies and applications in the biomedical sciences Three- color fluorescence in situ hybridization for the simultaneous detection of multiple nucleic acid sequences Numerical chromosome aberrations in bladder cancer detected by in situ hybridization Molecular testing? |
| cord-027865-p1epjn51 | So, the question arises, why not just do IHC? |
| cord-027865-p1epjn51 | Two major choices must be made for the preparation of a probe: • What type of nucleic acid is to be used( DNA or RNA, single or double stranded)? |
| cord-027865-p1epjn51 | What type of label is to be incorporated into the probe? |
| cord-048471-7jszm1nd | The genomelinked protein VPg of the Norwalk virus binds eIF3, suggesting its role in translation initiation complex recruitment VPg of murine norovirus binds translation initiation factors in infected cells New Ways of Initiating Translation in Eukaryotes? |
| cord-018564-3igg5s57 | ( Reversibility:?) |
| cord-018564-3igg5s57 | ( Reversibility:?) |
| cord-018564-3igg5s57 | , 45] P? |
| cord-018564-3igg5s57 | [ 50] Subunits? |
| cord-023608-w2g7v7g1 | Or perhaps the( immuno)pathology of virus infections may boost some specific enzyme reactions in the infected organs? |
| cord-023608-w2g7v7g1 | So perhaps it is time to consider some less explored scaffolds in the search for new nucleos(t)ide antivirals? |
| cord-023608-w2g7v7g1 | Why is then the structural diversity of antiviral nucleos(t)ide drugs still quite limited? |
| cord-048198-zjufx4fo | In other words, was nucleotide+1 of the junction sequence derived from the body TRS or the leader TRS? |
| cord-035110-5lkzhjfh | : Use them or target them? |
| cord-035110-5lkzhjfh | gold Open Access which fosters wider collaboration and increased citations maximum visibility for your research: over 100 M website views per year submit your research? |
| cord-029779-9b6zs1sb | to from here? |
| cord-048478-ftlb5b95 | The role of 2 0-5 0 oligoadenylate- activated ribonuclease L in apoptosis RNase L- independent specific 28S rRNA cleavage in murine coronavirus- infected cells Programmed death in yeast as adaptation? |
| cord-048478-ftlb5b95 | rRNA degradation- apoptotic or not? |
| cord-022262-ck2lhojz | But what about receptor specificity of these viruses? |
| cord-022262-ck2lhojz | Do these considerations allow us to safely conclude that, after its global eradication, poliovirus will have no chance to re- emerge through enterovirus evolution? |
| cord-022262-ck2lhojz | Does the history of the polyprotein determine how picornaviruses may evolve in the future? |
| cord-022262-ck2lhojz | For example, the precursor 3CD pr~ can be cleaved into 3C pr~ and 3CD p~ by a( cis?) cleavage in which the 3C/3CD pr~ proteinase is involved. |
| cord-022262-ck2lhojz | Genetic analyses have indicated that template switching occurs( predominantly?) |
| cord-022262-ck2lhojz | How do the multiple mechanisms alluded to interlace to produce a specific picornavirus disease syndrome? |
| cord-022262-ck2lhojz | How it is Likely to Evolve in the Future? |
| cord-022262-ck2lhojz | Moreover, if the genome has to be translated for replication to occur, how can inhibition of translation promote RNA synthesis? |
| cord-022262-ck2lhojz | The mechanism of RNA recombination in poliovirus Primary structure, gene organization and polypeptide expression of poliovirus RNA The poliovirus receptor protein is produced both as membrane- bound and secreted forms Transgenic mice susceptible to poliovirus Q[3 replicase as repressor of Q[3 RNA- directed protein synthesis Evolution of RNA genomes: does the high mutation rate necessitate high rate of evolution of viral proteins? |
| cord-022262-ck2lhojz | We have discussed different aspects relevant to picornavirus evolution, but we did not address one crucial question: Are picornaviruses a successful family? |
| cord-022262-ck2lhojz | What are the mechanisms by which the picornaviruses and other RNA virus families have diversified? |
| cord-022262-ck2lhojz | What is the identity of picornaviruses? |
| cord-022262-ck2lhojz | What is the mechanism by which poliovirus may eliminate foreign sequences? |
| cord-252268-o63ep08b | A/ H1N1 virus is as virulent as its wild- type counterpart in mice and ferrets Expression profiles of human interferon- alpha and interferon- lambda subtypes are ligand- and celldepenedent Differential pathological and immune responses in newly weaned ferrets are associated with a mild clinical outcome of pandemic 2009 H1N1 infection Assessing the development of oseltamivir and zanamivir resistance in A(H5N1) influenza viruses using a ferret model Detection of intracellular cytokines by flow cytometry Pandemic H1N1 influenza virus causes a stronger inflammatory response than seasonal H1N1 influenza virus in ferrets Effects of carteolol hydrochloride on the in vitro production of LPS- induced proinflammatory cytokines by murine macrophage New animal models of cystic fibrosis: what are they teaching us? |
| cord-102766-n6mpdhyu | The reverse complement Here a virus, there a virus, everywhere the same virus? |
| cord-102766-n6mpdhyu | Why are RNA virus mutation rates so damn high? |
| cord-102934-7e2mqooe | Can urinary exosomes act as treatment response markers in prostate cancer? |
| cord-102934-7e2mqooe | Could EVs play a role in the pathogenesis of cancer? |
| cord-102934-7e2mqooe | Could EVs play a role in the therapeutics of cancer? |
| cord-102934-7e2mqooe | how and why? |
| cord-104162-fe51v2pt | Does the comparative method rule? |
| cord-104162-fe51v2pt | Is conservation necessarily a good indicator of likely therapeutic success? |
| cord-104162-fe51v2pt | The heart of the HIV RNA packaging signal? |
| cord-022128-r8el8nqm | A unique intra- molecular fidelity- modulating mechanism identified in a viral RNA- dependent RNA polymerase Defective or effective? |
| cord-022128-r8el8nqm | Coxsackievirus B3 mutator strains are attenuated in vivo A single- nucleotide synonymous mutation in the gag gene controlling human immunodeficiency virus type 1 virion production Is sex necessary for the proliferation and transmission of Pneumocystis? |
| cord-022128-r8el8nqm | Linking RNA sequence, structure, and function on massively parallel highthroughput sequences Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad- spectrum antivirals? |
| cord-022128-r8el8nqm | Pnemocystis genetic variability: cryptic biological species or clonal near- clades? |
| cord-022128-r8el8nqm | Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population Replication slippage involves DNA polymerase pausing and dissociation Genome instability: a conserved mechanism of ageing? |
| cord-022128-r8el8nqm | Ribavirin resistance in hepatitis C virus replicon- containing cell lines conferred by changes in the cell line or mutations in the replicon RNA Altering the intracellular environment increases the frequency of tandem repeat deletion during Moloney murine leukemia virus reverse transcription Transfection- mediated generation of functionally competent Tula hantavirus with recombinant S RNA segment Low- fidelity polymerases of alphaviruses recombine at higher rates to overproduce defective interfering particles Mechanisms of retroviral mutation Reproductive clonality in protozoan pathogens ─ truth or artefact? |
| cord-022128-r8el8nqm | reveals the dynamic nature of viral genome evolution Molecular Basis of Virus Evolution Functional and genetic plasticities of the poliovirus genome: quasi- infectious RNAs modified in the 5'-untranslated region yield a variety of pseudorevertants Nonreplicative homologous RNA recombination: promiscuous joining of RNA pieces? |
| cord-253115-ekgdsv4f | In vivo tumor targeting via nanoparticlemediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models Novobrantseva, siRNA and the lung: research tool or therapeutic drug? |
| cord-253024-b393ea2u | Are deletions contributing to the increased rates of recombination among the group F RNA+ mutants? |
| cord-103853-ar09nzmw | +? ± 718 estimations including a flanking hairpin included in the Illumina array experiments( described in ref. 5). |
| cord-103853-ar09nzmw | To compare packages, we report the correlation between log(; C) ±718/; C)@AB) and log(>+? ±718), which excludes the effect of selection for K 456@AB. |
| cord-103735-nil1vv6h | A pneumonia outbreak associated with a new coronavirus of probable bat origin The SARS, MERS and novel coronavirus( COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? |
| cord-103735-nil1vv6h | Cold Spring Harb Surveillance of wild birds for avian influenza virus Chances and limitations of wild bird monitoring for the avian influenza virus H5N1-detection of pathogens highly mobile in time and space African swine fever epidemic Tracking zoonotic pathogens using blood- sucking flies as'flying syringes Empty forests, empty stomachs? |
| cord-023017-k6edtg58 | ( I? |
| cord-023017-k6edtg58 | 12mmHg or by? |
| cord-023017-k6edtg58 | 12mmHg or? lo%), had a significantly lower probability of bleeding( P?O.Ol) and of requiring hospital admission because decompensations of cirrhosis, while survival probability was higher, both after acute and chronic beta- blocker administration. |
| cord-023017-k6edtg58 | 2) what are the risk factors of IR; 3) does IR play a role( and to what extent) in the occurrence of steatosis? |
| cord-023017-k6edtg58 | 20% in 38% of cases and decreased? lo% in 74%( P?O.OOl) after acute beta- blocker. |
| cord-023017-k6edtg58 | 4) is IR involved in the progression of fibrosis? |
| cord-023017-k6edtg58 | Control( 0.65 cellsltriad? |
| cord-023017-k6edtg58 | Hemodynamic responders( defining response as a decrease of HVPG to? |
| cord-023017-k6edtg58 | If CD34 numbers are adjusted for the total mononuclear cell counts then the increase in circulating stem cells between these two groups became even more apparent( 0.44? 0.34 and 4.98XlOX6 cellsll 24.8; p<0.05). |
| cord-023017-k6edtg58 | In patients with chronic hepatitis C, we adressed the following issues: 1) is IR the cause or consequence of steatosis and fibrosis? |
| cord-023017-k6edtg58 | Methods: Chronic liver injury was induced in rats by CC14 treatment( of the development of cirrhosis in Group 1( histopathology score of 3.7? |
| cord-023017-k6edtg58 | Our results suggest that: 1) A decrease of HVFG? |
| cord-023017-k6edtg58 | Overall, patients with PNF were older( 55.7 t 10 vs. 48.99 years, p=0.03) and had higher peak ALT levels( 141? 185 vs. 40 2 32 U/ L, p=0.04). |
| cord-023017-k6edtg58 | Studies dealing with the prevention of rebleeding have shown that hemodynamic response to pharmacological treatment of portal hypertension is adequate when the hepatic venous pressure gradient( HVPG) decreases to? |
| cord-023017-k6edtg58 | The HCV RNA was done by a PCR technique with a detectability cutoff of 50-copieslmb Results: Both randomized groups were similar at baseline without statistical significant difference, 190( 90%) were infected with genotype 4, mean age was 39.5 years? |
| cord-023017-k6edtg58 | The HVPG decreased? |
| cord-023017-k6edtg58 | The area of ASMA- positive cells was however significantly decreased by SSR 182289 from 3.83? 1.04 to 2.86 |
| cord-023017-k6edtg58 | The mean level of circulating apoptotic cells in Day 1 recipient PBMC was higher than healthy controls( 0.9% t-0.2 vs 0.2%? |
| cord-023017-k6edtg58 | Using ROC curve a decrease of HVPG? |
| cord-253862-jl1zhg13 | Teicoplanin: an alternative drug for the treatment of COVID-19? |
| cord-253862-jl1zhg13 | what next? |
| cord-103823-3rchp9yy | In other words, RNAVLab helps scientists to address questions such as''what are the mechanisms of nodavirus RNA replication?". |
| cord-253539-0kcujnfa | Could the disparity among the closterovirus CPs and CP duplicates be due to their involvement in and specific adaptation to transmission by different types of vector? |
| cord-253539-0kcujnfa | How is the"rattlesnake"particle assembled? |
| cord-103925-i73ymrov | implementation and evaluation of a new integration package How good are my data and what is the resolution? |
| cord-103163-0rreoh4o | Defective interfering or delightfully interesting? |
| cord-103163-0rreoh4o | RNA- RNA interactions of genomic segments Disruption of Specific RNA- RNA Interactions in a Double- Stranded RNA Virus Inhibits Genome Packaging and Virus Infectivity Inter- segment complementarity in orbiviruses: a driver for co- ordinated genome packaging in the Reoviridae? |
| cord-103899-6tqm99g1 | COVID-19, SARS and MERS: are they closely related? |
| cord-103899-6tqm99g1 | MicroRNAs in inflammatory lung disease- master regulators or target practice? |
| cord-103899-6tqm99g1 | The role of microRNAs in respiratory viral infection: friend or foe? |
| cord-103899-6tqm99g1 | The role of microRNAs in respiratory viral infection: friend or foe? |
| cord-103899-6tqm99g1 | targeting TGFβ1 enhances antimicrobial capacity in Mycobacterium tuberculosis infected mice COVID-19 in the heart and the lungs: could we"Notch"the inflammatory storm? |
| cord-103430-x6zzuu7v | A Worldwide Emerging Threat? |
| cord-103430-x6zzuu7v | An Outbreak of Human Semliki Forest Virus Infections in Central African 13 Isolation of a 15 newly recognized alphavirus from mosquitoes in Vietnam and evidence for human infection 16 and disease Me Tri virus: a Semliki Forest virus strain from Vietnam? |
| cord-103430-x6zzuu7v | The molecular pathogenesis of Semliki Forest 9 virus: a model virus made useful? |
| cord-103739-mmkrwj8t | Do viruses subvert cholesterol 863 homeostasis to induce host cubic membranes? |
| cord-103739-mmkrwj8t | Replication Organelle Comprises Double- Membrane Vesicles and Zippered Endoplasmic 766 Does form meet function in the 769 coronavirus replicative organelle? |
| cord-254592-wa5il5go | The Lancet Estimates of Ebola virus case- fatality ratio in the 2014 West African outbreak Current knowledge on lower virulence of Reston Ebola virus Prediction and prevention of the next pandemic zoonosis Host- parasite relations, vectors, and the evolution of disease severity Pathogen survival in the external environment and the evolution of virulence Mechanisms of pathogenesis, infective dose and virulence in human parasites Challenging the trade- off model for the evolution of virulence: is virulence management feasible? |
| cord-022348-w7z97wir | And if so, what is the virus adapting to? |
| cord-022348-w7z97wir | Are They Adapting or Merely Changing? |
| cord-022348-w7z97wir | But if it were non- linear? |
| cord-022348-w7z97wir | Can quasispecies define a transient molecular clock? |
| cord-022348-w7z97wir | Conservative perhaps, but is there any suggestion that viruses are more or less so than other replicons? |
| cord-022348-w7z97wir | Could symptomatic infections reflect bottleneck transmission of those fitter clones with asymptomatic( subclinical) infection representing fitness- compromised clones? |
| cord-022348-w7z97wir | Does the VP1 gene of foot- and- mouth disease virus behave as a molecular clock? |
| cord-022348-w7z97wir | For outbred populations, is it in fact virulence? |
| cord-022348-w7z97wir | Given the inevitability of mutation, is it possible that over the aeons natural selection has selected for proteins that are robust, those that are capable of absorbing endless substitutions? |
| cord-022348-w7z97wir | How are innate and adaptive immune responses coupled and how are they influenced by genetic polymorphisms? |
| cord-022348-w7z97wir | How good are viruses as machines? |
| cord-022348-w7z97wir | How many rounds of infection are necessary to fix mutations? |
| cord-022348-w7z97wir | Is not fourth best in any large population remarkable? |
| cord-022348-w7z97wir | Might this finding suggest that the optimum is actually away from mass production? |
| cord-022348-w7z97wir | Problems arise transposing it to the in vivo situation, notably: 9 First and foremost: how does one determine fitness in vivo? |
| cord-022348-w7z97wir | Should such measurements score intrahost viral titres or transmission probabilities from an index case? |
| cord-022348-w7z97wir | We come to the basic question- to what extent is genetic variation exploited by an RNAvirus, if at all? |
| cord-022348-w7z97wir | What fraction of amino acid residues is necessary for function? |
| cord-022348-w7z97wir | What is the value of n? |
| cord-022348-w7z97wir | What might a viral species be? |
| cord-022348-w7z97wir | While they are fit enough to survive, are they the best possible? |
| cord-022348-w7z97wir | Why do they mutate rapidly yet remain phenotypically stable? |
| cord-022348-w7z97wir | Why is the evolution of RNA viruses so conservative? |
| cord-022348-w7z97wir | Why is this? |
| cord-022348-w7z97wir | Yet is that correct? |
| cord-022348-w7z97wir | Yet who can remember the name of any Olympic athlete who came in fourth? |
| cord-254916-y1rw9q11 | The antiviral compound remdesivir potently inhibits RNA- dependent RNA polymerase from middle East respiratory syndrome coronavirus Structural basis for inhibition of the RNA- dependent RNA polymerase from SARS- CoV-2 by remdesivir Remdesivir and SARS- CoV-2: structural requirements at both nsp12 RdRP and nsp14 exonuclease active- sites First case of 2019 novel coronavirus in the United States A rush to judgment? |
| cord-253501-hkxlq3os | an active ubiquitinproteasome system Inhibition of hepatitis E virus replication by proteasome inhibitor is nonspecific Zinc salts block hepatitis E virus replication by inhibiting the activity of viral RNA- dependent RNA polymerase Zinc: an overview Zinc in innate and adaptive tumor immunity Zinc: A complementary factor in the treatment of chronic hepatitis C? |
| cord-252433-0e9lonq4 | But how do viruses use noncoding RNAs to promote their replication? |
| cord-252433-0e9lonq4 | So which factors are required for the export of cellular mRNAs? |
| cord-252433-0e9lonq4 | So, why is this uncapped viral mRNA translated more efficiently than capped cellular mRNAs? |
| cord-252433-0e9lonq4 | mRNAs reach the cytoplasm? |
| cord-253466-7gpije5d | , 2004) induces vesicles and dispersal of the Golgi apparatus, which begs the questions, does this mutant use a different process for forming the replication complex, or do the mutations in 3A allow the proteins to compete with BFA for GBF1 recruitment? |
| cord-253466-7gpije5d | African swine fever virus is wrapped by the endoplasmic reticulum Cellular COPII proteins are involved in production of the vesicles that form the poliovirus replication complex Vaccinia virus membrane proteins p8 and p16 are cotranslationally inserted into the rough endoplasmic reticulum and retained in the intermediate compartment Daxx: Death or survival protein? |
| cord-253466-7gpije5d | Biogenesis from scratch? |
| cord-253466-7gpije5d | Hijacking components of the secretory pathway for replication of poliovirus RNA Does common architecture reveal a viral lineage spanning all three domains of life? |
| cord-253466-7gpije5d | Viral interactions with the cytoskeleton of mammalian cells Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex Assembly of vaccinia virus revisited: De novo membrane synthesis or acquisition from the host? |
| cord-254747-vox5xsgd | Athmer et al., 2017)? |
| cord-254747-vox5xsgd | How does nsp15 mediate the evasion of host sensors? |
| cord-254747-vox5xsgd | How does the EndoU activity of nsp15 alter the fate of dsRNA? |
| cord-254747-vox5xsgd | How is this EndoU activity regulated to avoid unwanted cleavage events? |
| cord-254747-vox5xsgd | What is the natural target of EndoU? |
| cord-253307-4bpdfgau | ( iv) is the presence of a specific viral RNA sequence responsible for this inhibition? |
| cord-253307-4bpdfgau | If the shut- off of cellular protein synthesis is due to the increase of nuclear proteins in the cytoplasm, a number of new questions arise:( i) which nuclear proteins are able to block cellular mRNA translation?; |
| cord-253307-4bpdfgau | mRNA? |
| cord-253307-4bpdfgau | what is the molecular mechanism that triggers the release of nuclear proteins?; and |
| cord-254100-u6x5zd4i | An umbraviral protein, involved in long- distance RNA movement, binds viral RNA and forms unique, protective ribonucleoprotein complexes Eukaryotic elongation factor 1A interacts with Turnip mosaic virus RNA- dependent RNA polymerase and VPg- Pro in virus- induced vesicles Regulation of host cell translation by viruses and effects on cell function Insights into nuclear organisation in plants as revealed by the dynamic distribution of Arabidopsis SR splicing factors Evolutionary origins of the RNA- guided nucleotide- modification complexes: from the primitive translation apparatus? |
| cord-254100-u6x5zd4i | The capsid protein of satellite panicum mosaic virus contributes to systemic invasion and interacts with its helper virus Getting the message across: How do plant cells exchange macromolecular complexes? |
| cord-254100-u6x5zd4i | The nucleolus-a gateway to viral infection? |
| cord-254100-u6x5zd4i | What's new in the nucleolus? |
| cord-254100-u6x5zd4i | viroid RNA in vitro and in vivo Pumpimg RNA: Nuclear bodybuilding along the RNP pipeline Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly? |
| cord-254070-v9gabn1a | Are mutation rates fixed for a given organism? |
| cord-254070-v9gabn1a | However, selection for mutagen- sensitive variants is more challenging, so how to generate low- fidelity variants? |
| cord-254070-v9gabn1a | Is There a Natural Range in RdRp Fidelity? |
| cord-254070-v9gabn1a | the missing link between structure and function of the viral RNA- dependent RNA polymerase? |
| cord-007890-bie1veti | ( 5?-GCAAGTTCTT- CAGCTTGTTT-3?). |
| cord-007890-bie1veti | ( 5?-TATTGCGCT- TAGAAAATTAA-3?) |
| cord-007890-bie1veti | ( hence, if we treat alcoholic cirrhosis patients with interferon could we have a favorable response?). |
| cord-007890-bie1veti | */does its aetiology matter? |
| cord-007890-bie1veti | And on the basis of which classification system should the two legs of such a trial be separated? |
| cord-007890-bie1veti | Can coins and paper currency transmit Bacillus anthracis? |
| cord-007890-bie1veti | Can varicella be eliminated by universal childhood vaccination? |
| cord-007890-bie1veti | Do the trials with interferon alfa for patients with HBV or HCV cirrhosis exhibit a favorable result due to the antiviral properties of interferon, or is interferon exhibiting anti- oncogenic potential?, and is HCC cytokine and hormone sensitive( view ongoing trials with somatostatine analogues versus HCC)? |
| cord-007890-bie1veti | Do the trials with interferon alfa for patients with HBV or HCV cirrhosis exhibit a favorable result due to the antiviral properties of interferon, or is interferon exhibiting anti- oncogenic potential?, and is HCC cytokine and hormone sensitive( view ongoing trials with somatostatine analogues versus HCC)? |
| cord-007890-bie1veti | Does their end in the stage of cirrhosis? |
| cord-007890-bie1veti | HBV Á/ HCV and liver carcinogenesis: where does the viral influence end? |
| cord-007890-bie1veti | How ethical is it to conduct a randomised trial where one leg of cirrhotic patients is left without antiviral therapy? |
| cord-007890-bie1veti | How much hope can be put on a drug that seems to be partly useless before its initiation? |
| cord-007890-bie1veti | In vivo activity of glycopeptides against S. aureus infection in a rabbit endocarditis model: is MIC predictive for in vivo efficacy? |
| cord-007890-bie1veti | Is progression towards HCC independent of the etiology of cirrhosis( since alcoholic cirrhosis also proceeds to HCC)? |
| cord-007890-bie1veti | Lactulose, a factor that decreases endotoxaemia, in obstructive jaundice? |
| cord-007890-bie1veti | Moreover, do viral proteins with oncogenic potential exist( the controversy over the recently discovered HBV protein is still, unresolved)? |
| cord-007890-bie1veti | Our experience suggests a promising role of lamivudine in the treatment of acute hepatitis B, but how long such therapy have to be practiced and in which patients? |
| cord-007890-bie1veti | These strains was genotypically characterized for the mec A gene presence by PCR method using the mec A 1- 5?-AAA ATC CAT GGT AAA GGT TGG C-3? and the mec A 2 Á/5?-AGT TCT GCA GTA CCG GAT TTG C-3? primers( GIBCO, BRL). |
| cord-007890-bie1veti | These strains was genotypically characterized for the mec A gene presence by PCR method using the mec A 1- 5?-AAA ATC CAT GGT AAA GGT TGG C-3? and the mec A 2 Á/5?-AGT TCT GCA GTA CCG GAT TTG C-3? primers( GIBCO, BRL). |
| cord-007890-bie1veti | Which patients with HBV or HCV cirrhosis are eligible for interferon treatment? |
| cord-007890-bie1veti | and of transconjugants and the amplification by PCR of the gene aac(6?)-aph(2?? |
| cord-007890-bie1veti | and of transconjugants and the amplification by PCR of the gene aac(6?)-aph(2?? |
| cord-007890-bie1veti | can the associated morbidity and mortality in this rare but deadly disease be reduced? |
| cord-252871-qfrpuy3t | : do we need a fourth domain of life to explain the origin of eukaryotes? |
| cord-252871-qfrpuy3t | Can protein structure- based methods improve the evolutionary studies of viruses? |
| cord-252871-qfrpuy3t | Do well defined boundaries exist between cellular and viral lineages? |
| cord-252871-qfrpuy3t | How are RNA and DNA viruses evolutionarily related? |
| cord-252871-qfrpuy3t | How do we explain the origin and abundance of virus- specific genes in viral genomes? |
| cord-252871-qfrpuy3t | How to visualize and illustrate viruses( virus factories) if virions can not and should not be used to describe viruses? |
| cord-252871-qfrpuy3t | The path from the RNA world Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: A hypothesis for the origin of cellular domain Mimivirus: The emerging paradox of quasi- autonomous viruses Phylogenetic tree building in the genomic age Benefits of using molecular structure and abundance in phylogenomic analysis Can sequence phylogenies safely infer the origin of the global virome? |
| cord-252871-qfrpuy3t | Viral eukaryogenesis: was the ancestor of the nucleus a complex DNA virus? |
| cord-254895-ym0jsir5 | Interferon alpha/ beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/ beta MyD88-dependent and-independent murine cytomegalovirus sensing for IFN- alpha release and initiation of immune responses in vivo Viral infection switches non- plasmacytoid dendritic cells into high interferon producers Innate antiviral responses by means of TLR7-mediated recognition of single- stranded RNA Does Toll- like receptor 3 play a biological role in virus infections? |
| cord-254895-ym0jsir5 | What is the molecular basis for the rapid and robust interferon production in pDCs? |
| cord-254895-ym0jsir5 | What is the role of TLR9 for antiviral immunity in vivo? |
| cord-256325-q70rky3r | This raises the question: do henipavirus M proteins traffic through the nucleolus for other reasons? |
| cord-255883-mz6nyisw | Could SARS- CoV-2-induced hyperinflammation magnify the severity of coronavirus disease( CoViD-19) leading to acute respiratory distress syndrome? |
| cord-256510-orr2roxz | Do viruses subvert cholesterol homeostasis to induce host cubic membranes? |
| cord-256561-fnh2do4z | Intranasal antisense therapy: preclinical models with a clinical future? |
| cord-257652-ndt8f812 | What does virus evolution tell us about virus origins? |
| cord-256444-grw5s2pf | Are nonstructural protein genes really unnecessary? |
| cord-256444-grw5s2pf | Finally, what of the potential interaction between the virus and host, which has been one of the major themes of virology in recent years? |
| cord-256444-grw5s2pf | Is the nucleus contributing to the coronavirus replication? |
| cord-256444-grw5s2pf | What determines the site of virion budding? |
| cord-256444-grw5s2pf | What is responsible for that? |
| cord-022888-dnsdg04n | /CRTAM on gd T cells? |
| cord-022888-dnsdg04n | As the results show, could there not be a direct relationship between the HLA system and the development of SA or TBC, or in contrast, was the first patient missdiagnosed of TBC being a good prognosis SA? |
| cord-022888-dnsdg04n | Could Carabin play a role of negative regulator of B cell function? |
| cord-022888-dnsdg04n | How is the IGSF4-CRTAM axis regulated in T cells? |
| cord-022888-dnsdg04n | a one- year prospective birth cohort study PC09/16 TO WHAT EXTENT T- SPOT.TB COULD BE USED IN THE DIAGNOSIS OF TUBERCULOSIS IN CHILDREN EXPOSED TO TB INFECTION? |
| cord-258035-2tk7maqk | Drosophila cells Role for a bidentate ribonuclease in the initiation step of RNA interference Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways ATP requirements and small interfering RNA structure in the RNA interference pathway Phenotypic silencing of cytoplasmic genes using sequence- specific double- stranded short interfering RNA and its application in the reverse genetics of wild type negative- strand RNA viruses Short interfering RNA confers intracellular antiviral immunity in human cells siRNA- directed inhibition of HIV-1 infection Modulation of HIV-1 replication by RNA interference Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference RNA interference directed against viral and cellular targets inhibits human immunodeficiency virus type 1 replication Selective silencing of viral gene expression in HPV- positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs RNA interference: the new somatic cell genetics? |
| cord-258035-2tk7maqk | The future of cancer management: translating the genome, transcriptome, and proteome Long- term infection and transformation of dermal microvascular endothelial cells by human herpesvirus 8 Kaposi's sarcoma- associated herpesvirusinduced upregulation of the c- kit proto- oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells Altered patterns of cellular gene expression in dermal microvascular endothelial cells infected with Kaposi's sarcoma- associated herpesvirus Inhibition of c- kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor Gene silencing in mammals by small interfering RNAs Morpholino oligos: making sense of antisense? |
| cord-256508-ce59ovan | Are reinfections less severe than the first? |
| cord-256508-ce59ovan | How does COVID-19 kill? |
| cord-256508-ce59ovan | This case lead to several open questions: How frequent is reinfection? |
| cord-256508-ce59ovan | Tracking down RNA synthesis Viral load dynamics and disease severity in patients infected with SARS- CoV-2 in Zhejiang province, China Pathological findings of COVID-19 associated with acute respiratory distress syndrome A Novel Coronavirus from Patients with Pneumonia in China Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 Treatment of hepatitis C virus infection with direct- acting antiviral agents: 100% cure? |
| cord-256508-ce59ovan | Where does the virus replicate? |
| cord-256508-ce59ovan | Will vaccine protect against reinfections? |
| cord-258172-p54j4zzo | : What Is the Evidence? |
| cord-256615-gvq8uyfk | How can we be better prepared to identify emerging pathogens early? |
| cord-256615-gvq8uyfk | How many pathogenic viruses remain to be discovered? |
| cord-256615-gvq8uyfk | Is it feasible to predict which animal viruses have the potential to cause disease in humans? |
| cord-256615-gvq8uyfk | The global distribution and burden of dengue Airborne transmission of influenza A/ H5N1 virus between ferrets Role of receptor binding specificity in influenza A virus transmission and pathogenesis Venezuelan equine encephalitis emergence: enhanced vector infection from a single amino acid substitution in the envelope glycoprotein Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come? |
| cord-256615-gvq8uyfk | The human virome: new tools and concepts Human polyomaviruses in disease and cancer Bats and their virome: an important source of emerging viruses capable of infecting humans Overviews of pathogen emergence: which pathogens emerge, when and why? |
| cord-256615-gvq8uyfk | What is the best strategy for identifying and limiting the menace from novel, zoonotic viruses? |
| cord-258595-bk35vxlr | Umwelt SARS- CoV-2 from faeces to wastewater treatment: What do we know? |
| cord-031907-ilhr3iu5 | Extracellular Vesicle- based liquid biopsy in Acute Myeloid Leukaemia: a reliable source of residual disease biomarkers? |
| cord-259927-xh9cw9ao | Can a school- based hand hygiene program reduce asthma exacerbations among elementary school children? |
| cord-255090-2gpsu1y4 | A mutation was generated at the position of 410 of the pVP1-EGFP- N1, which is equivalent to the VP1- 410 G? |
| cord-255090-2gpsu1y4 | A reporter plasmid, designated pVP1-EGFP- N1- 410A, was generated by utilizing the pVP1-EGFP- N1 plasmid as template, and a G? |
| cord-255090-2gpsu1y4 | A substitution at the position of 410 of the pVP1-EGFP- N1( temporarily designated pVP1-EGFP- N1- 410 G), and the latter was introduced C? |
| cord-255090-2gpsu1y4 | It was also possible that the C? |
| cord-255090-2gpsu1y4 | Moreover, although the single nucleotide substitution C? |
| cord-255090-2gpsu1y4 | Nevertheless, the nucleotide substitution C? |
| cord-255090-2gpsu1y4 | Particularly, as we tested, a single nucleotide substitution G? |
| cord-255090-2gpsu1y4 | Potent and specific genetic interference by double- stranded RNA in Caenorhabditis elegans Expression of shRNA from a tissue- specific pol II promoter is an effective and safe RNAi therapeutic Poliovirus escape from RNA interference: short interfering RNA- target recognition and implications for therapeutic approaches Rapid control of foot- and- mouth disease outbreaks: is RNAi a possible solution? |
| cord-255090-2gpsu1y4 | The UK foot- and- mouth disease outbreak-the aftermath Inhibition of foot- and- mouth disease virus replication by small interfering RNA RNAi- based knockdown of HBx mRNA in HBx- transformed and HBV- producing human liver cells Interfering antiviral immunity: application, subversion, hope? |
| cord-255090-2gpsu1y4 | The former was introduced G? |
| cord-255090-2gpsu1y4 | compared with pVP1-EGFP- N1- 410 G, indicating that the single nucleotide substitution G? |
| cord-261417-4pf5nsw2 | Noncoding RNA- guided recruitment of transcription factors: A prevalent but undocumented mechanism? |
| cord-261160-g92zhv19 | Lactate dehydrogenase- elevating virus: an ideal persistent virus? |
| cord-260168-rb7j94dh | Diff erential expression of chemokines and their receptors in adult and neonatal macrophages infected with human or avian infl uenza viruses Induction of proinfl ammatory cytokines in human macrophages by infl uenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-260782-1lm8tzbc | A new papillomavirus of possums( Trichosurus vulpecula) associated with typical wartlike papillomas Routes of transmission of wobbly possum disease Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain Lactate dehydrogenase- elevating virus, equine arteritis virus, and simian hemorrhagic fever virus: a new group of positive- strand RNA viruses Lactate dehydrogenaseelevating virus: an ideal persistent virus? |
| cord-023354-f2ciho6o | ( with a selfadministered questionnaire with an open- ended question: How does blood donation affect you? |
| cord-023354-f2ciho6o | /socially during or after blood donation?) revealed that perceived negative effects( fatigue, diminished physical working capacity, vertigo/ dizziness, susceptibility to infections etc) |
| cord-023354-f2ciho6o | : will it become reality? |
| cord-023354-f2ciho6o | After the first 10 years with haemovigilance in the European countries, what has been the outcome of this big effort? |
| cord-023354-f2ciho6o | Against this background where should our attentions focus? |
| cord-023354-f2ciho6o | Aim: Does the interpretation of reports obtained through Outcome Review lead to an increase in the number of products per run and the overall productivity of the apheresis center? |
| cord-023354-f2ciho6o | An ISO standard for blood transfusion? |
| cord-023354-f2ciho6o | Are transfusion guidelines evidence- based? |
| cord-023354-f2ciho6o | Being anti- D immunoglobulin a product that has the potential risk of infection transmission, is it appropriate to use indiscriminately as a routine antenatal prophylaxis? |
| cord-023354-f2ciho6o | In addition, how much are we willing to pay for protection against emerging viruses? |
| cord-023354-f2ciho6o | Is it a mutual decision making between physician and patient? |
| cord-023354-f2ciho6o | Mobilization is also seen following the use of other cytokines( i.e. kit- L, Flt-3 L, IL-3) or chemokines( i.e. IL-8, Gro?), complement activation, etc., but the detailed mechanisms or the interdependence of these other pathways with the ones already proposed have not been worked out. |
| cord-023354-f2ciho6o | Scientific evidence to fully answer the questions'when are platelet components clinically effective'and'what do we really know?'is limited. |
| cord-023354-f2ciho6o | Should patients with thalassemia intermedia be regularly transfused? |
| cord-023354-f2ciho6o | The research theme of this questionnaire is as follows:'What is the level of knowledge and of motivation in the non- remunerated and voluntary blood donation at students?' |
| cord-023354-f2ciho6o | The subjects selected and debated were( i) what are the medical considerations for reducing the rate of mistransfusion? |
| cord-023354-f2ciho6o | These ties to industry create a tension that actually is or can be perceived as • work internationally; • send young volunteers to international youth forums; • employ young people in your organisation; Why use volunteers in blood donor recruitment? |
| cord-023354-f2ciho6o | We therefore resorted to developing our own model but ask the question: Why not have one international standard for blood transfusion? |
| cord-023354-f2ciho6o | What is however the meaning of informed consent? |
| cord-023354-f2ciho6o | Who cares about the quality of life of the chronic patients treated with blood products? |
| cord-023354-f2ciho6o | Who will hear it? |
| cord-023354-f2ciho6o | and( ii) what are the medical considerations for managing a limited blood inventory? |
| cord-023354-f2ciho6o | to apply which screening method? |
| cord-023354-f2ciho6o | your Trima ® can be? |
| cord-259603-bh198xgl | 4 G is sufficient to support cap- independent translation in the absence of eIF4E Genome- wide analysis of protein- protein interactions and involvement of viral proteins in SARS- CoV replication Nidovirus transcription: how to make sen- se …? |
| cord-259603-bh198xgl | CORONAVIRUS nsp7- 10: SMALL BUT CRITICAL REGULATORY SUBUNITS? |
| cord-259603-bh198xgl | Clearly, both the role of nsp8( primase or processivity factor?) and the initiation mechanism employed by the nsp12-RdRp require further study. |
| cord-259603-bh198xgl | The broadspectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen Ribavirin's antiviral mechanism of action: lethal mutagenesis? 0 |
| cord-259603-bh198xgl | mRNA stability SARS coronavirus accessory proteins Biochemical characterization of arterivirus nonstructural protein 11 reveals the nidovirus- wide conservation of a replicative endoribonuclease Arterivirus Nsp1 modulates the accumulation of minus- strand templates to control the relative abundance of viral mRNAs Does form meet function in the coronavirus replicative organelle? |
| cord-262753-jld1ygxt | -is there a P function in vesicular stomatitis virus? |
| cord-261279-6mef38eo | The emergence of human coronavirus emc: How scared should we be? |
| cord-255495-xnoppq3y | Are there neutralized antibodies or protective reaction induced by the SARS- CoV-2 infection? |
| cord-255495-xnoppq3y | But what one can say about the duration of these entry events for SARS- CoV-2( COVID-19), whose spike protein has 10- 20 fold higher affinity for ACE2 more than that of SARS- CoV( Wrapp et al., 2020)? |
| cord-255495-xnoppq3y | COVID-19 patients infectious? |
| cord-255495-xnoppq3y | Communicated by Ramaswamy H. Sarma Are we ready to the fact that we must adapt ourselves to live with COVID-19 and, perhaps, for a long time? |
| cord-255495-xnoppq3y | How should such recovered patients which were retested positive for SARS- CoV-2 be managed? |
| cord-255495-xnoppq3y | Is such scenario could be mimicked by the Vero E6 infection with SARS- CoV? |
| cord-255495-xnoppq3y | Is this"Trojan horse"strategy of the release of the SARS- CoV-2-loaded exosomes or EDMVs represent a reasonable explanation for the appearance of the viral RNA in the recovered COVID-19 patients 7- 14 day post discharge? |
| cord-255495-xnoppq3y | May we target double membrane vesicles and oxysterol- binding protein to combat SARS- CoV-2 infection? |
| cord-255495-xnoppq3y | The life cycle of SARS coronavirus in Vero E6 cells Viral effects on the content and function of extracellular vesicles Complement as a target in COVID-19? |
| cord-255495-xnoppq3y | The role of extracellular vesicles in COVID-19 virus infection Recurrence of positive SARS- CoV-2 in patients recovered from COVID-19 Retest positive for SARS- CoV-2 RNA of"recovered"patients with COVID-19: Persistence, sampling issues, or re- infection? |
| cord-255495-xnoppq3y | This case raised a fundamental question, from what she has died: Was it from the virus or some other cause? |
| cord-255495-xnoppq3y | This opportunity raised several critical questions, such as what are the reasons for the reappearance of SARS- CoV-2 RNA in some patients recovered from COVID-19 and what are the mechanisms of such reinfection, reactivation, and relapse? |
| cord-255495-xnoppq3y | What one can find in such hidden exosomes/ EDMVs, if they do exists, and where do they hide during the"silence"time period; i.e. after the recovered patients discharge from the hospitals and before the viral RNA starts to reappear again, reflecting the COVID-19 reinfection/ reactivation but now under the conditions of the primed acquired immune response? |
| cord-255495-xnoppq3y | Will we see protection or reinfection in COVID-19? |
| cord-255495-xnoppq3y | the hidden SARS- CoV-2 RNA is coming from? |
| cord-255495-xnoppq3y | vaccines work on such reinfected, relapsed, or reactivated COVID-19 patients? |
| cord-260345-ugd8kkor | ( 1992) H ow does photodynamic therapy work? |
| cord-260345-ugd8kkor | ~e growth factor? |
| cord-265095-lf5j4ic7 | The question is, of course, what is it that makes a pseudoknot so suitable for inducing efficient frameshifting? |
| cord-263315-g7os15m1 | Can Anopheles Gambiae Be Infected with Wolbachia Pipientis? |
| cord-259233-smmhhroe | Cold Spring Harbor Perspectives in Late budding domains and host proteins in enveloped virus release Mechanisms for enveloped virus budding: can some viruses do without an ESCRT? |
| cord-259233-smmhhroe | Could CD4 capture by CD8+ T cells play a role in HIV spreading? |
| cord-259233-smmhhroe | Exosomes and retroviruses: the chicken or the egg? |
| cord-259233-smmhhroe | Herpesviruses remodel host membranes for virus egress Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses ORF1a- encoded replicase subunits are involved in the membrane association of the arterivirus replication complex Kunjin virus: an Australian variant of West Nile? |
| cord-259233-smmhhroe | Trojan exosomes riding the Trojan horse? |
| cord-259233-smmhhroe | Virus assembly and plasma membrane domains: which came first? |
| cord-259233-smmhhroe | and what is its purpose? |
| cord-260422-z22t57ju | a cysteine- rich peptide mimics the normal metal- linked dimer interface Fuzzy complexes: a more stochastic view of protein function HIV-1 Tat, apoptosis and the mitochondria: a tubulin link? |
| cord-262347-ejhz9rra | Serum immune responses to the proteins of porcine reproductive and respiratory syndrome( PRRS) virus Analysis of RNA- dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure Determination of 5 0-leader sequences from radically disparate strains of porcine reproductive and respiratory syndrome virus reveals the presence of highly conserved sequence motifs Identification of neutralizing and nonneutralizing epitopes in the porcine reproductive and respiratory syndrome virus GP5 ectodomain Survival of porcine reproductive and respiratory syndrome virus in houseflies Evaluation of mosquitoes, Aedes vexans, as biological vectors of porcine reproductive and respiratory syndrome virus Genetic manipulation of arterivirus alternative mRNA leader- body junction sites reveals tight regulation of structural protein expression Regulation of relative abundance of arterivirus subgenomic mRNAs Nidovirus transcription: how to make sense …? |
| cord-263468-996kl9jz | A Biased RNA Polymerase? |
| cord-263468-996kl9jz | Does the higher order structure of the influenza virus ribonucleoprotein guide sequence rearrangements in influenza viral RNA? |
| cord-263468-996kl9jz | To test this hypothesis, we sequenced the complete N gene and one third to one half of the f? |
| cord-260705-huyyw5z6 | How do viruses interact with stress- associated RNA granules? |
| cord-260705-huyyw5z6 | Virus factories: Associations of cell organelles for viral replication and morphogenesis A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication Virus factories, double membrane vesicles and viroplasm generated in animal cells Aggresomes and pericentriolar sites of virus assembly: Cellular defense or viral design? |
| cord-263157-8jin6oru | However, an important question arose from these pioneer studies: is the virion- associated incoming genomic viral RNA targeted by RNAi? |
| cord-264944-7xj27r98 | After inactivation of the proteinase for?' |
| cord-264678-wt0lvhfl | Can a scientist predict the potential IRES elements before experiment? |
| cord-023346-8sqbqjm1 | ( with a selfadministered questionnaire with an open- ended question: How does blood donation affect you? |
| cord-023346-8sqbqjm1 | /socially during or after blood donation?) revealed that perceived negative effects( fatigue, diminished physical working capacity, vertigo/ dizziness, susceptibility to infections etc) |
| cord-023346-8sqbqjm1 | : will it become reality? |
| cord-023346-8sqbqjm1 | After the first 10 years with haemovigilance in the European countries, what has been the outcome of this big effort? |
| cord-023346-8sqbqjm1 | Against this background where should our attentions focus? |
| cord-023346-8sqbqjm1 | Aim: Does the interpretation of reports obtained through Outcome Review lead to an increase in the number of products per run and the overall productivity of the apheresis center? |
| cord-023346-8sqbqjm1 | An ISO standard for blood transfusion? |
| cord-023346-8sqbqjm1 | Are transfusion guidelines evidence- based? |
| cord-023346-8sqbqjm1 | Being anti- D immunoglobulin a product that has the potential risk of infection transmission, is it appropriate to use indiscriminately as a routine antenatal prophylaxis? |
| cord-023346-8sqbqjm1 | In addition, how much are we willing to pay for protection against emerging viruses? |
| cord-023346-8sqbqjm1 | Is it a mutual decision making between physician and patient? |
| cord-023346-8sqbqjm1 | Mobilization is also seen following the use of other cytokines( i.e. kit- L, Flt-3 L, IL-3) or chemokines( i.e. IL-8, Gro?), complement activation, etc., but the detailed mechanisms or the interdependence of these other pathways with the ones already proposed have not been worked out. |
| cord-023346-8sqbqjm1 | Scientific evidence to fully answer the questions'when are platelet components clinically effective'and'what do we really know?'is limited. |
| cord-023346-8sqbqjm1 | Should patients with thalassemia intermedia be regularly transfused? |
| cord-023346-8sqbqjm1 | The research theme of this questionnaire is as follows:'What is the level of knowledge and of motivation in the non- remunerated and voluntary blood donation at students?' |
| cord-023346-8sqbqjm1 | The subjects selected and debated were( i) what are the medical considerations for reducing the rate of mistransfusion? |
| cord-023346-8sqbqjm1 | These ties to industry create a tension that actually is or can be perceived as • work internationally; • send young volunteers to international youth forums; • employ young people in your organisation; Why use volunteers in blood donor recruitment? |
| cord-023346-8sqbqjm1 | We therefore resorted to developing our own model but ask the question: Why not have one international standard for blood transfusion? |
| cord-023346-8sqbqjm1 | What is however the meaning of informed consent? |
| cord-023346-8sqbqjm1 | Who cares about the quality of life of the chronic patients treated with blood products? |
| cord-023346-8sqbqjm1 | Who will hear it? |
| cord-023346-8sqbqjm1 | and( ii) what are the medical considerations for managing a limited blood inventory? |
| cord-023346-8sqbqjm1 | to apply which screening method? |
| cord-023346-8sqbqjm1 | your Trima ® can be? |
| cord-262282-9xh51cd1 | : What have we learned? |
| cord-262282-9xh51cd1 | A review of Dengvaxia ®: Development to deployment DNA vaccines: Technology and application as anti- parasite and anti- microbial agents DNA vaccines- How far from clinical use? |
| cord-262282-9xh51cd1 | Can a virus transmit even more actively than SARS- CoV-2? |
| cord-262282-9xh51cd1 | Can more active transmission be accompanied by higher virulence? |
| cord-262282-9xh51cd1 | What factors shape phage pharmacokinetics and bioavailability? |
| cord-265855-zf52vl11 | A public health problem? |
| cord-265855-zf52vl11 | Chloroquine is a zinc ionophore New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? |
| cord-264051-ps0x2es1 | Phosphodiesterase Inhibitors: Could They Be Beneficial for the Treatment of COVID-19? |
| cord-264051-ps0x2es1 | T T Ischaemic stroke and SARS- CoV-2 infection: A causal or incidental association? |
| cord-262076-b5u5hp2r | confer HIV-1 resistance Human immunodeficiency virus type 1 escapes from RNA interference- mediated inhibition Inhibition of HIV-1 replication with designed miRNAs expressed from RNA polymerase II promoters Human immunodeficiency virus type 1 escape from RNA interference HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome RNA interference as an antiviral approach: targeting HIV-1 Silencing of HIV-1 with RNA interference: a multiple shRNA approach Specific inhibition of human immunodeficiency virus type 1 replication by antisense oligonucleotides: an in vitro model for treatment Can hammerhead ribozymes be efficient tools to inactivate gene function? |
| cord-267115-6jqdi417 | Does the human placenta express the canonical cell entry mediators for SARS- CoV-2? |
| cord-266960-kyx6xhvj | your research? |
| cord-263987-ff6kor0c | A generalization of substitution evolution models of nucleotides to genetic motifs Empirical and structural models for insertions and deletions in the divergent evolution of proteins Empirical analysis of protein insertions and deletions determining parameters for the correct placement of gaps in protein sequence alignments Indel PDB: a database of structural insertions and deletions derived from sequence alignments of closely related proteins Sequence context of indel mutations and their effect on protein evolution in a bacterial endosymbiont Alignment of phylogenetically unambiguous indels in Shewanella Identification of transposable elements using multiple alignments of related genomes Statistical alignment: computational properties, homology testing and goodness- of- fit General continuous- time Markov model of sequence evolution via insertions/ deletions: are alignment probabilities factorable? |
| cord-263987-ff6kor0c | General continuous- time Markov model of sequence evolution via insertions/ deletions: local alignment probability computation Erratum to: General continuous- time Markov model of sequence evolution via insertions/ deletions: are alignment probabilities factorable? |
| cord-263987-ff6kor0c | The question naturally arises: how to extend the model to describe the evolution of an entire sequence, not just individual sites? |
| cord-262511-96xp1v0r | ARED 3.0: the large and diverse AU- rich transcriptome AU- rich elements and associated factors: are there unifying principles? |
| cord-262511-96xp1v0r | Can the RNA decay- promoting activity of the RNA- binding proteins be harnessed as an antiviral therapeutic strategy? |
| cord-266921-x9q7dwc4 | Are there dedicated, highly specific nucleases that do this controlled trimming? |
| cord-266921-x9q7dwc4 | Conversely, how are unstructured or damaged RNAs identified and turned over? |
| cord-266921-x9q7dwc4 | how do cells maintain folded RNA structures, such as tRNA and ribosomes, in the presence of all these keen ribonucleases? |
| cord-263645-wupre5uj | What is functional and what is junk? |
| cord-267326-355q6k6k | H7 carrying the Stx 2 gene in sewage from different countries Characterization of metagenomes in urban aquatic compartments reveals high prevalence of clinically relevant antibiotic resistance genes in wastewaters Variation of bacterial communities with water quality in an urban tropical catchment Unhealthy landscapes: policy recommendations on land use change and infectious disease emergence Disease emergence from global climate and land use change Agricultural intensification, priming for persistence and the emergence of Nipah virus: a lethal bat- borne zoonosis Gut DNA viromes of Malawian twins discordant for severe acute malnutrition Surveillance of enteric viruses and coliphages in a tropical urban catchment Obtaining genomes from uncultivated environmental microorganisms using FACS- based single- cell genomics Viral and microbial community dynamics in four aquatic environments Occurrence of Pepper Mild Mottle Virus( PMMoV) in Groundwater from a Karst Aquifer System in the Yucatan Peninsula VirSorter: mining viral signal from microbial genomic data Evolution and diversity of the Microviridae viral family through a collection of 81 new complete genomes assembled from virome reads Metavir 2: new tools for viral metagenome comparison and assembled virome analysis Evaluating the efficacy of commercial kits for viral DNA/ RNA extraction Metagenomic characterisation of the viral community of lough neagh, the largest freshwater lake in Ireland Eukaryotic viruses in wastewater samples from the United States Relationship of microbiota and cyanobacterial secondary metabolites in planktothricoides- dominated bloom Viral metagenomics on animals as a tool for the detection of zoonoses prior to human infection? |
| cord-023364-ut56gczm | ( with a selfadministered questionnaire with an open- ended question: How does blood donation affect you? |
| cord-023364-ut56gczm | /socially during or after blood donation?) revealed that perceived negative effects( fatigue, diminished physical working capacity, vertigo/ dizziness, susceptibility to infections etc) |
| cord-023364-ut56gczm | : will it become reality? |
| cord-023364-ut56gczm | After the first 10 years with haemovigilance in the European countries, what has been the outcome of this big effort? |
| cord-023364-ut56gczm | Against this background where should our attentions focus? |
| cord-023364-ut56gczm | Aim: Does the interpretation of reports obtained through Outcome Review lead to an increase in the number of products per run and the overall productivity of the apheresis center? |
| cord-023364-ut56gczm | An ISO standard for blood transfusion? |
| cord-023364-ut56gczm | Are transfusion guidelines evidence- based? |
| cord-023364-ut56gczm | Being anti- D immunoglobulin a product that has the potential risk of infection transmission, is it appropriate to use indiscriminately as a routine antenatal prophylaxis? |
| cord-023364-ut56gczm | In addition, how much are we willing to pay for protection against emerging viruses? |
| cord-023364-ut56gczm | Is it a mutual decision making between physician and patient? |
| cord-023364-ut56gczm | Mobilization is also seen following the use of other cytokines( i.e. kit- L, Flt-3 L, IL-3) or chemokines( i.e. IL-8, Gro?), complement activation, etc., but the detailed mechanisms or the interdependence of these other pathways with the ones already proposed have not been worked out. |
| cord-023364-ut56gczm | Scientific evidence to fully answer the questions'when are platelet components clinically effective'and'what do we really know?'is limited. |
| cord-023364-ut56gczm | Should patients with thalassemia intermedia be regularly transfused? |
| cord-023364-ut56gczm | The research theme of this questionnaire is as follows:'What is the level of knowledge and of motivation in the non- remunerated and voluntary blood donation at students?' |
| cord-023364-ut56gczm | The subjects selected and debated were( i) what are the medical considerations for reducing the rate of mistransfusion? |
| cord-023364-ut56gczm | These ties to industry create a tension that actually is or can be perceived as • work internationally; • send young volunteers to international youth forums; • employ young people in your organisation; Why use volunteers in blood donor recruitment? |
| cord-023364-ut56gczm | We therefore resorted to developing our own model but ask the question: Why not have one international standard for blood transfusion? |
| cord-023364-ut56gczm | What is however the meaning of informed consent? |
| cord-023364-ut56gczm | Who cares about the quality of life of the chronic patients treated with blood products? |
| cord-023364-ut56gczm | Who will hear it? |
| cord-023364-ut56gczm | and( ii) what are the medical considerations for managing a limited blood inventory? |
| cord-023364-ut56gczm | to apply which screening method? |
| cord-023364-ut56gczm | your Trima ® can be? |
| cord-263302-z5uhrta5 | This finding raises an intriguing question: Why does MHV use multiple pathways to regulate the expression of a single gene? |
| cord-266127-phv08xe2 | Is RNA interference a physiologically relevant innate antiviral immune response in mammals? |
| cord-264159-e9071tyv | Apart from basic science discovery, how do these insights affect clinical practice in infectious disease? |
| cord-264159-e9071tyv | Do they share similar features that might be reasons for their susceptibility of infection? |
| cord-264159-e9071tyv | Furthermore, how are host cells'phenotypes influenced by infection individually and temporally? |
| cord-264159-e9071tyv | How do the states of infected cells affect pathogen replication and infection outcome? |
| cord-264159-e9071tyv | How does this preference arise? |
| cord-264159-e9071tyv | Why are certain people more susceptible to infections? |
| cord-264159-e9071tyv | Why are some infected individuals asymptomatic or display only mild symptoms? |
| cord-264159-e9071tyv | Why are there differences in terms of disease progression and outcomes among patients? |
| cord-267533-nmgtan4e | The outbreaks of COVID-19 The SARS, MERS and novel coronavirus( COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? |
| cord-268071-ow2aijmj | Why are RNA virus mutation rates so damn high? |
| cord-266985-9qwttt2y | Thus, in the case of NoV, it may be possible to simplify step 2 into assuming that p 2? 1 for those individuals who are genetically susceptible in having a functional FUT2 gene, while p 2= 0 for those who are genetically resistant through having a nonfunctional FUT2 gene. |
| cord-004584-bcw90f5b | ( Na? dependent)[ 4]. |
| cord-004584-bcw90f5b | / H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | 4000 lmol photons m-2 s-1) have shown that fast component of ms- DF was inhibited faster with time than in case of action of Co 2? and excess light. |
| cord-004584-bcw90f5b | 7, 1518 Budapest, HungaryWide- line proton NMR FID, echoes, spin- lattice and spin- spin relaxation times were measured at 82.55 MHz frequency in the-70 ° C to? |
| cord-004584-bcw90f5b | A putative outer- membrane cytochrome, OmcF, is crucial for Fe 3? |
| cord-004584-bcw90f5b | A recent candidate for pH regulation within early endosomes and TGN is the highly conserved intracellular Na? |
| cord-004584-bcw90f5b | Acyl transfer from lipids without enzyme catalysis: a new paradigm for membrane protein ageing? |
| cord-004584-bcw90f5b | Additional studies have shown that although neither the catalytic reaction nor the establishment of the DpH requires the presence of Na?, the presence of this ion increased the proton transport. |
| cord-004584-bcw90f5b | Analyzing the fluorescence relaxation kinetics,? |
| cord-004584-bcw90f5b | Ca 2? |
| cord-004584-bcw90f5b | Ca 2? and Mn 2?, that can be attributed to their sizes and coordination properties to specific ligands. |
| cord-004584-bcw90f5b | Ca 2? and Mn 2?, that can be attributed to their sizes and coordination properties to specific ligands. |
| cord-004584-bcw90f5b | Ca?? |
| cord-004584-bcw90f5b | Ca?? |
| cord-004584-bcw90f5b | Cell migration or proliferation? |
| cord-004584-bcw90f5b | ClpB is a hexameric AAA? |
| cord-004584-bcw90f5b | Combining all these results, a model for the coupling mechanism of complex I was proposed, suggesting the presence of two different energy coupling sites, one that works only as a proton pump( Na? independent), and the other functioning as a Na? |
| cord-004584-bcw90f5b | Combining all these results, a model for the coupling mechanism of complex I was proposed, suggesting the presence of two different energy coupling sites, one that works only as a proton pump( Na? independent), and the other functioning as a Na? |
| cord-004584-bcw90f5b | Compared to these channels, the voltage- dependence of TRPA1 is very weak( apparent number of gating charges* 0.4 versus 12 in K? channels) and its putative voltage- sensing domain most likely lies outside the S4 because TRPA1 completely lacks positively charged residues in this region. |
| cord-004584-bcw90f5b | Cytoplasmic dynein moves through uncoordinated action of the AAA1 ring domains Ahmet Yildiz Department of Physics, and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 USA Cytoplasmic dynein is a homodimeric AAA? |
| cord-004584-bcw90f5b | During action on chloroplasts only of Cd 2? |
| cord-004584-bcw90f5b | Forward and reverse transport directions were investigated at zero membrane potential using preparations with inside out and right side out oriented transporters with Na? or H? |
| cord-004584-bcw90f5b | Furthermore, Na? |
| cord-004584-bcw90f5b | Generalized epilepsy with febrile seizures plus( GEFS?, OMIM 604233) is a childhood genetic epilepsy syndrome correlated to mutations in the ancillary b- subunit of neuronal voltage- gated sodium channels( NaChs). |
| cord-004584-bcw90f5b | I reduce ubiquinone, it is suggested that the Na?/H? |
| cord-004584-bcw90f5b | I reduce ubiquinone, it is suggested that the Na?/H? |
| cord-004584-bcw90f5b | In addition, our systematic and quantitative analysis( in combination with genetic modifications) provides a tool to study the role of? |
| cord-004584-bcw90f5b | In both strains the pH dependence was associated with a systematic increase of the K m for Na? |
| cord-004584-bcw90f5b | In the photosynthetic reaction center( RC) of Rhodobacter sphaeroides, fast formation of the charge separated state P? |
| cord-004584-bcw90f5b | In the present work, Al 3? induced conformational change and instant oligomerization of aS have been studied using FRET and FCS as main techniques. |
| cord-004584-bcw90f5b | In the shorter(\ 1 ms) time scale, the dominating effect is the re- reduction of the oxidized primary donor( P?? |
| cord-004584-bcw90f5b | In the shorter(\ 1 ms) time scale, the dominating effect is the re- reduction of the oxidized primary donor( P?? |
| cord-004584-bcw90f5b | Initial expression levels were determined by either partial purification using Ni 2?-NTA |
| cord-004584-bcw90f5b | It was observed that the Na? |
| cord-004584-bcw90f5b | It was observed that this bacterial complex I is able of H? |
| cord-004584-bcw90f5b | K? |
| cord-004584-bcw90f5b | Nigericin, a peptide that acts as an H?-K? |
| cord-004584-bcw90f5b | Nigericin, a peptide that acts as an H?-K? |
| cord-004584-bcw90f5b | Result indicates that damage sites of action Cd 2? |
| cord-004584-bcw90f5b | Simultaneous action of Cd 2? and photoinhibitory illumination( |
| cord-004584-bcw90f5b | Taken together with our results on the subcellular localization of the native NHE7, these unique biochemical features provide new insights on the biological function and pathological implications of this intracellular Na? |
| cord-004584-bcw90f5b | The aim of these studies was to clarify whether the specific crystalline structure of protein and protein- substrate interactions are significant for H? |
| cord-004584-bcw90f5b | The available data are restricted and only the re- oxidation of the reduced primary quinone( Q A-? |
| cord-004584-bcw90f5b | The average lifetime of donor in the presence of acceptor increases with the increase of Al 3? |
| cord-004584-bcw90f5b | The coupling ion of the system was shown to be the H? |
| cord-004584-bcw90f5b | The first and best characterized GEFS? |
| cord-004584-bcw90f5b | The intrinsic Tyr fluorescence rises sharply within the mixing dead time, reflecting an enhanced hydrophobicity of the Tyr environment and a fast conformational change of aS. Al 3? |
| cord-004584-bcw90f5b | The simultaneous effect of photoinhibitory illumination and toxic action of heavy metals ions( Cd 2? |
| cord-004584-bcw90f5b | The steadystate level at Cd 2? |
| cord-004584-bcw90f5b | The transmembrane part of the tetrameric TRPA1 is structurally related to the voltagegated K? channels in which the conserved charged residues within the fourth transmembrane region( S4) constitute part of a voltage sensor. |
| cord-004584-bcw90f5b | These data allowed to advance a transport mechanism based on competing Na? |
| cord-004584-bcw90f5b | This inner structure transmits local signals due to ATP binding and hydrolysis by AAA? domains. |
| cord-004584-bcw90f5b | This model was reinforced by further studies performed in the presence of the Na? |
| cord-004584-bcw90f5b | This work was supported by the Italian Association for Cancer Research( AIRC), the Istituto Toscano Tumori and the Associazione Noi per Voi Differential hydration, void volume: which factor provides the main contribution to DV u? |
| cord-004584-bcw90f5b | Thus, notable variations in the RNA binding specificity was observed for the divalent ions of Mg 2? |
| cord-004584-bcw90f5b | Under symmetrical Na? |
| cord-004584-bcw90f5b | Under symmetrical pH conditions with a Na? |
| cord-004584-bcw90f5b | We assume that binding site of Cd 2? is Y Z or CaMn 4-cluster, one of the recombination partners with P 680? |
| cord-004584-bcw90f5b | We assume that binding site of Cd 2? is Y Z or CaMn 4-cluster, one of the recombination partners with P 680? |
| cord-004584-bcw90f5b | We have developed somatic cell genetic techniques that enable the selection of variant cells able to resist H? |
| cord-004584-bcw90f5b | We reported previously that the increase of the cholesterol content of the cell membrane( in vitro) modified the biophysical parameters of the gating of Kvl.3 K? ion channels in human T- lymphocytes. |
| cord-004584-bcw90f5b | What makes an amyloid toxic: morphology, structure or interaction with membranes? |
| cord-004584-bcw90f5b | Whole- cell K? |
| cord-004584-bcw90f5b | and Co 2? are donor and acceptor side of PS2, accordingly. |
| cord-004584-bcw90f5b | and Co 2?) |
| cord-004584-bcw90f5b | and H? |
| cord-004584-bcw90f5b | and Na? |
| cord-004584-bcw90f5b | and U 6? reduction and also for microbial electricity production( 4). |
| cord-004584-bcw90f5b | being transported to the periplasm, contributing in this way to the establishment of the electrochemical potential difference, while Na? is translocated to the cytoplasm[ 4]. |
| cord-004584-bcw90f5b | both alkaline pH and Na? |
| cord-004584-bcw90f5b | by extracellular Ca 2? entry probably through mechanosensitive channels. |
| cord-004584-bcw90f5b | concentration, indicating aS adopts a more extended conformation upon Al 3? |
| cord-004584-bcw90f5b | hERG K? channels is associated with increased risk of arrhythmias. |
| cord-004584-bcw90f5b | killing through plasma membrane expression of H? extruders. |
| cord-004584-bcw90f5b | the fast component of ms- DF, which originates via radiative recombination of reaction center with the CaMn 4-cluster or Y Z on donor side of PS2, is inhibited stronger than at action of only Co 2?. |
| cord-004584-bcw90f5b | treatment is remain stable, while at Co 2? |
| cord-268206-ino9srb6 | : 2019-nCoV Could chloroquine/hydroxychloroquine be harmful in coronavirus disease 2019( COVID-19) treatment? |
| cord-268206-ino9srb6 | a systematic review Full- genome evolutionary analysis of the novel corona virus( 2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event Severe acute respiratory syndrome Obesity and COVID-19 severity in a Intranasal immunization with inactivated SARS- CoV( SARS- associated coronavirus) induced local and serum antibodies in mice Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses Nitazoxanide: a first- in- class broad- spectrumantiviral agent Nitazoxanide, a new drug candidate forthe treatment of Middle East respiratorysyndrome coronavirus Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-263357-krvei97r | How does the genomic analysis of HCoV- EMC expedite further research on this new human virus? |
| cord-263357-krvei97r | What can analysis of its RNA genome tell us about this new human coronavirus? |
| cord-263357-krvei97r | What features of the genome and its translational strategy are similar to or different from those of other coronaviruses? |
| cord-263357-krvei97r | What is the relationship between HCoV- EMC and known coronaviruses? |
| cord-263357-krvei97r | What questions must be answered to show whether HCoV- EMC is likely to cause an epidemic or adapt to become endemic in humans? |
| cord-269011-230p8rsf | How, in the face of this enormous flexibility in accommodating all these various numbers and combinations of viral components, do coronaviruses manage to maintain specificity? |
| cord-268139-tgpsu4qz | Do the deletion and point mutations change the nature of nsp1-protein interactions? |
| cord-268139-tgpsu4qz | What function does this domain have during MHV RNA synthesis? |
| cord-268139-tgpsu4qz | Why is the nsp1 amino- terminus required for MHV replication? |
| cord-267475-6f4h3cck | 25 kDa movement protein 12 and 8 kDa movement proteins f?? |
| cord-267475-6f4h3cck | 25 kDa movement protein 12 and 8 kDa movement proteins f?? |
| cord-267475-6f4h3cck | Do the 5 0 untranslated domains of human cDNAs challenge the rules for initiation of translation( or is it vice versa New ways of initiating translation in eukaryotes? |
| cord-267475-6f4h3cck | How does the 40S subunit hold on at a terminator codon, in order to reinitiate? |
| cord-267475-6f4h3cck | What drives migration of the 40S subunit during the scanning phase? |
| cord-267475-6f4h3cck | What prevents reinitiation when the size of the first ORF exceeds a certain length? |
| cord-270550-if748w2n | Why weight? |
| cord-269466-9hnal9ad | How do Plant Viruses Utilize the Host Secretory Pathway for Efficient Viral Replication and Spread? |
| cord-269466-9hnal9ad | Tomato bushy stunt virus Ubiquitination of tombusvirus p33 replication protein plays a role in virus replication and binding to the host Vps23p ESCRT protein Arabidopsis myosin XI- K localizes to the motile endomembrane vesicles associated with F- actin The cell biology of Tobacco mosaic virus replication and movement Myosindependent endoplasmic reticulum motility and F- actin organization in plant cells Integrity of the early secretory pathway promotes, but is not required for, severe acute respiratory syndrome coronavirus RNA synthesis and virus- induced remodeling of endoplasmic reticulum membranes Missing links? |
| cord-268337-o6lo55o8 | HIV mRNAs are capped, so why would a virus that expresses capped mRNAs encode a function that cleaves eIF4 G and represses cap- dependent translation and scanning? |
| cord-268337-o6lo55o8 | How would this be expected to affect translation? |
| cord-268337-o6lo55o8 | So how does proteinase cleavage of PABP affect translation? |
| cord-268337-o6lo55o8 | What could be the missing part(s) of the translation shutoff model? |
| cord-268337-o6lo55o8 | What effects do viral proteinases have on translation of viral mRNA? |
| cord-268337-o6lo55o8 | What else could have been missing from the shutoff model? |
| cord-268337-o6lo55o8 | While proteases of many picornaviruses and caliciviruses are known to cleave several translation factors, what of other RNA viruses? |
| cord-268337-o6lo55o8 | the function of PABP and PABP- interacting proteins in mRNA translation Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms Cleavage of poly(A)-binding protein by Coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff? |
| cord-269766-arjoemla | But how many infected patients carry the virus in their tears? |
| cord-269194-b1wlr3t7 | Are treatment options available? |
| cord-269194-b1wlr3t7 | For how long will the patient need to be on therapy? |
| cord-269194-b1wlr3t7 | Simple amplification- based assay: A nucleic acid- based point- of- care platform for HIV-1 testing HIV-1 viral load blips are of limited clinical significance HIV cure and eradication: How will we get from the laboratory to effective clinical trials? |
| cord-269194-b1wlr3t7 | Transducers Quantitation of mRNA by the polymerase chain reaction Prehistoric eye disease( trachoma?) |
| cord-269194-b1wlr3t7 | What treatment regimen should be prescribed? |
| cord-270594-62xotol3 | Why VP7 exited various protein expression patterns among virion, infected cells and larvae? |
| cord-268718-tt07cwrf | ( b) Which ACE2-expressing organs are prone to SARS- CoV-2 infection? |
| cord-268718-tt07cwrf | ( c) Is higher expression level of ACE2 equal to greater COVID-19 susceptibility? |
| cord-268718-tt07cwrf | Potential T- cell and B- cell epitopes of 2019-nCoV Rapid- response vaccines- does DNA offer a solution? |
| cord-268718-tt07cwrf | The neuroinvasive potential of SARS- CoV2 may be at least partially responsible for the respiratory failure of COVID-19 patients Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study Self- reported olfactory and taste disorders in patients with severe acute respiratory coronavirus 2 infection: a cross- sectional study High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa SARS- CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes SARS- CoV-2: recent reports on antiviral therapies based on lopinavir/ ritonavir, darunavir/ umifenovir, hydroxychloroquine, remdesivir, favipiravir and other drugs for the treatment of the new coronavirus Treatment efficacy analysis of traditional Chinese medicine for novel coronavirus pneumonia( COVID-19): an empirical study from Wuhan Remdesivir in covid-19 Vitamin effects on the immune system: vitamins a and D take centre stage Vitamin D and influenza- prevention or therapy? |
| cord-268718-tt07cwrf | Therefore, the following questions regarding ACE2 expression in relation to COVID-19 susceptibility can be asked:( a) Which parts of the body express ACE2? |
| cord-268718-tt07cwrf | driving pulses of zoonotic viruses in reservoir- host populations Global patterns in coronavirus diversity Surveillance of bat coronaviruses in Kenya identifies relatives of human coronaviruses NL63 and 229E and their recombination history Bat- to- human: spike features determining'host jump'of coronaviruses SARS- CoV, MERS- CoV, and beyond Link of a ubiquitous human coronavirus to dromedary camels Cross- host evolution of severe acute respiratory syndrome coronavirus in palm civet and human MERS coronavirus neutralizing antibodies in camels Pangolins harbor SARS- CoV-2-related coronaviruses Are pangolins the intermediate host of the 2019 novel coronavirus( 2019-nCoV)? |
| cord-268718-tt07cwrf | is faecal- oral transmission of SARS- CoV-2 possible? |
| cord-271648-m2c5bvuj | A Review of Virus- Host Interactions Human coronaviruses: What do they cause? |
| cord-271648-m2c5bvuj | medRxiv 2020 Comparing mask fit and usability of traditional and nanofibre N95 filtering facepiece respirators before and after nursing procedures A close shave? |
| cord-269726-z0frgm7s | ( SARS- CoV-2) be infected again? |
| cord-269726-z0frgm7s | : Report from a designated transfer hospital in Chongqing Recurrence of positive SARS- CoV-2 RNA in COVID-19: a case report Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound? |
| cord-269726-z0frgm7s | Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound? |
| cord-269726-z0frgm7s | Is novel coronavirus 2019 reinfection possible? |
| cord-269726-z0frgm7s | Is recurrence possible in coronavirus disease 2019( COVID-19)? |
| cord-269726-z0frgm7s | The clinical features and outcomes of discharged coronavirus disease 2019 patients: a prospective cohort study Re- infection by COVID-19: a real threat for the future management of pandemia? |
| cord-269726-z0frgm7s | The dilemma of COVID-19 recurrence after clinical recovery Persistent positivity and fluctuations of SARS- CoV-2 RNA in clinically- recovered COVID-19 patients Probable causes and risk factors for positive SARS- CoV-2 test in recovered patients: evidence from Brunei Darussalam Epidemiological characteristics of COVID-19 patients in convalescence period Chest CT study of fifteen COVID-19 patients with positive RT- PCR retest results after discharge Rate of re- positive RT- PCR test among patients recovered from COVID-19 Discontinuation of antiviral drugs may be the reason for recovered COVID-19 patients testing positive again Changes in serum virus- specific IgM/ IgG antibody in asymptomatic and discharged patients with reoccurring positive COVID-19 nucleic acid test( RPNAT) Chest CT and clinical follow- up of discharged patients with COVID-19 in Wenzhou City A cluster of the Corona Virus Disease 2019 caused by incubation period transmission in Wuxi Re- positive coronavirus disease 2019 PCR test: could it be a reinfection? |
| cord-269726-z0frgm7s | The issue of recurrently positive patients who recovered from COVID-19 according to the current discharge criteria: investigation of patients from multiple medical institutions in Wuhan Positive RT- PCR nasopharyngeal swab in patients recovered from COVID-19 disease: when does quarantine really end? |
| cord-022889-lv6fy6e6 | -Are plant ncRNAs more stable than animal( mammalian) ncRNAs? |
| cord-022889-lv6fy6e6 | -Do changes in RNAse activity, due to pathologies or human polymorphisms, influence dietary exposure? |
| cord-022889-lv6fy6e6 | -Do exogenous ncRNAs( naked RNAs) resist the conditions of the gastrointestinal tract environment? |
| cord-022889-lv6fy6e6 | -How does exogenous RNAs uptake in mammalian cells occur? |
| cord-022889-lv6fy6e6 | -What are the biological barriers for the exogenous RNAs after absorption and entering into the mammalian circulatory system? |
| cord-022889-lv6fy6e6 | -What are the biological barriers to consumed RNAs? |
| cord-022889-lv6fy6e6 | -What are the main differences between mammalian and plant ncRNAs? |
| cord-022889-lv6fy6e6 | -What are the specific tissue barriers to exogenous ncRNA function? |
| cord-022889-lv6fy6e6 | -What is known about the half- life of ncRNAs? |
| cord-022889-lv6fy6e6 | -What is known about the movement of plant ncRNAs? |
| cord-022889-lv6fy6e6 | -What is the cellular fate of exogenous ncRNAs once inside the cell? |
| cord-022889-lv6fy6e6 | -What is the function of plant ncRNAs? |
| cord-022889-lv6fy6e6 | -What routes of administration have been used for RNA- based therapeutics? |
| cord-022889-lv6fy6e6 | -What type of ncRNAs are described in plants? |
| cord-022889-lv6fy6e6 | -Which human or animal cells( i.e. lymphocytes, macrophages, myeloid) are possibly involved in immune responses mediated by plant- derived ncRNAs? |
| cord-022889-lv6fy6e6 | -Which innate immunity mediators( i.e. chemokines, cytokines) have been identified in humans and animals as associated to effects of plant- derived ncRNAs? |
| cord-022889-lv6fy6e6 | -Why is it relevant to consider ncRNA stability outside the organism of origin( plant)? |
| cord-022889-lv6fy6e6 | Because this specific topic is especially salient to future understanding of the possible food/ feed risk assessment of ncRNAs- based GM plants, all the identified studies were further evaluated by title and abstract and their relevance to answering the identified key questions: does the literature describe the effect of exogenous plant- origin ncRNAs when consumed orally? |
| cord-022889-lv6fy6e6 | In silico identification of plant miRNAs in mammalian breast milk exosomes-- a small step forward? |
| cord-022889-lv6fy6e6 | In silico identification of plant miRNAs in mammalian breast milk exosomes-- a small step forward? |
| cord-022889-lv6fy6e6 | Only one key question was identified in the preparatory phase:-What are the biological barriers within the gastrointestinal tract to ingested exogenous RNAs? |
| cord-022889-lv6fy6e6 | Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi Detection of Plant miRNAs Abundance in Human Breast Milk In silico identification of plant miRNAs in mammalian breast milk exosomes-- a small step forward? |
| cord-022889-lv6fy6e6 | Selected full- text studies were analysed for their relevance to answering the following key question:-Is there evidence for influence of exogenous plant ncRNAs on the gut microbiota related to the immune system? |
| cord-022889-lv6fy6e6 | Since these findings are important for the risk assessment of ncRNA- based GM plants, the key question was presented in its positive and negative forms as follow: are there studies describing the presence of exogenous RNAs in the biological fluids and tissues of humans and/or animals? |
| cord-022889-lv6fy6e6 | Studies were further evaluated for their relevance to answer the key questions identified for this section:-What are the pharmacokinetic properties of RNA- based therapeutics? |
| cord-022889-lv6fy6e6 | The complex exogenous RNA spectra in human plasma: an interface with human gut biota? |
| cord-022889-lv6fy6e6 | The complex exogenous RNA spectra in human plasma: an interface with human gut biota? |
| cord-022889-lv6fy6e6 | The key questions identified to refine the literature search for this specific topic were:-Is there evidence of any toxicological effects of plant- derived dietary exogenous ncRNAs? |
| cord-022889-lv6fy6e6 | The key questions identified using the above key words were:-Which test methods or approaches are available to investigate the possible role of plant- derived exogenous ncRNAs on the immune system of humans or animals? |
| cord-022889-lv6fy6e6 | The search was refined by filtering for relevance to answering the identified key questions: is there any clear transport of exogenous ncRNAs into mammalian cells? |
| cord-022889-lv6fy6e6 | To assist and refine the search, studies were further filtered for their relevance to the key question identified: is the oral route of administration relevant for RNA- based therapeutic development? |
| cord-022889-lv6fy6e6 | To more appropriately cover this section and to refine the search, the following key questions were identified during the preparatory phase:-What is the general amount of RNAs naturally occurring in edible plants? |
| cord-022889-lv6fy6e6 | any natural vehicles for oral administration of exogenous ncRNAs? |
| cord-022889-lv6fy6e6 | bee pollen miRNAs in serum of mice Chemical modification patterns compatible with high potency dicer- substrate small interfering RNAs Is RNA interference involved in intrinsic antiviral immunity in mammals? |
| cord-022889-lv6fy6e6 | certain types of plant ncRNAs more or less stable than others? |
| cord-022889-lv6fy6e6 | derived extracellular vesicles attenuates arthritis in two mouse models Exosomes as a Nanodelivery System: a Key to the Future of Neuromedicine? |
| cord-022889-lv6fy6e6 | disease conditions modify the pharmacokinetic properties of RNAs when administered to mammals? |
| cord-022889-lv6fy6e6 | exogenous ncRNAs also used to exert RNAi effects in fish or birds? |
| cord-022889-lv6fy6e6 | exogenous ncRNAs consumed in an amount sufficient to exert a local biological effect?Are there other common examples of exogenous ncRNAs( other than plant- origin) that could exert a biological effect on the GI tract and its annex glands when ingested orally? |
| cord-022889-lv6fy6e6 | exogenous ncRNAs evaluated quantitatively? |
| cord-022889-lv6fy6e6 | exposure to RNAs change in different diet types? |
| cord-022889-lv6fy6e6 | human or animal immune response(s), innate or adaptive, are possibly associated with administration of plant- derived exogenous ncRNAs? |
| cord-022889-lv6fy6e6 | is it known about the pharmacodynamic properties of RNA- based therapeutics? |
| cord-022889-lv6fy6e6 | key questions were identified and the studies then further filtered for their relevance to the these:-Are exogenous RNAs taken up by mammalian cells? |
| cord-022889-lv6fy6e6 | molecular mechanisms are involved in exogenous ncRNAs trafficking inside the cell? |
| cord-022889-lv6fy6e6 | ncRNAs- based therapeutics-delivered by oral administration or other GI tract routes of administration- exert a biological effect in the GI tract or its annex glands? |
| cord-022889-lv6fy6e6 | orthologous of environmental RNAs transporters in lower organisms( i.e. SID family of proteins) involved in the mammalian exogenous ncRNA mechanism of uptake? |
| cord-022889-lv6fy6e6 | percentage of total plant RNAs are ncRNAs, miRNAs, siRNAs, lncRNAs or dsRNAs? |
| cord-022889-lv6fy6e6 | possible interactions related to unintended RNAi- mediated gene regulation? |
| cord-022889-lv6fy6e6 | possibly mediated by administration of plant- derived ncRNAs? |
| cord-022889-lv6fy6e6 | so, what makes a plant ncRNA more stable than its animal( mammalian) counterpart? |
| cord-022889-lv6fy6e6 | stability properties under GI tract conditions normally evaluated? |
| cord-022889-lv6fy6e6 | the literature describe negative results or contradictory results regarding the possible biological effect of ncRNAs when consumed orally? |
| cord-022889-lv6fy6e6 | the toxicological effects related to RNAi- mediated interaction with the human or animal genome? |
| cord-022889-lv6fy6e6 | there studies contradicting the presence of exogenous RNAs in the biological fluids and tissues of humans and/or animals? |
| cord-022889-lv6fy6e6 | types of formulation( delivery vehicles) are tested for RNA- based therapeutics for the oral route of administration or other gastrointestinal tract routes of administration? |
| cord-269975-1ebmq7t8 | Is in vitro antibiotic combination more effective than single- drug therapy against anthrax? |
| cord-270473-5tok4mqk | Mammalian HSP40/ DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature Extramitochondrial localization of mortalin/ mthsp70/ PBP74/ GRP75 Interaction of erythropoietin RNA binding protein with erythropoietin RNA requires an association with heat shock protein 70 mtHSP70, HSP60 and HSP40 bind to the MHV Maturation of the polymerase polyprotein of the coronavirus MHV strain JHM involves a cascade of proteolytic processing events Cloning and some novel characteristics of mitochondrial Hsp70 from Chinese hamster cells Functional interaction of heat shock protein GroEL with an RNase E- like activity in Escherichia coli Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein( Hsp60) in mammalian cells Mitochondrial- matrix proteins at unexpected locations: are they exported? |
| cord-271972-qhr6iir6 | How do RNA viruses avoid Xrn1-mediated degradation? |
| cord-270670-cubh9jxc | A principle of natural self- organization Genetic lesions associated with Muller's ratchet in an RNA virus Molecular biology, pathogenesis, and control of animal viruses Lethal mutagens: broad- spectrum antivirals with limited potential for development of resistance? |
| cord-270670-cubh9jxc | Can studies on complexity be of use to infectious diseases? |
| cord-270940-acwkh6ed | Have changes taken place in the viruses themselves? |
| cord-270940-acwkh6ed | Molecular evolution and distribution of dengue viruses type 1 and 2 in nature Epidemiology and clinical features of imported dengue fever in Europe: sentinel surveillance data from TropNetEurop Origins, evolution, and vector/ host coadaptations within the genus Flavivirus Diagnosis of tick- borne encephalitis West Nile virus: a growing concern? |
| cord-270940-acwkh6ed | What are the reasons for the appearance of all these emerging and re- emerging viruses? |
| cord-269866-3tpyj04y | How could these two products be translated from a single messenger RNA? |
| cord-270604-u62437dh | Ancient co- speciation of simian foamy viruses and primates Ancient origin and molecular features of the novel human T- lymphotropic virus type 3 revealed by complete genome analysis Risk factors for human disease emergence Small steps or giant leaps for male- killers? |
| cord-270604-u62437dh | The matrix protein gene sequence analysis reveals close relationship between peste des petits ruminants virus( PPRV) and dolphin morbillivirus Canine distemper virus- a morbillivirus in search of new hosts? |
| cord-270604-u62437dh | When do parasites fail to speciate in response to host speciation? |
| cord-271130-6s79q1c1 | ( Panthera leo) Role of feline immunodeficiency virus in lymphomagenesis-going alone or colluding? |
| cord-268122-74nj66vb | Are there any tissue specificities for NAD+ boosting, such tissue preferences of distinct NAD+ precursors? |
| cord-268122-74nj66vb | Delivering widespread BRCA testing and PARP inhibition to patients with ovarian cancer Synthetic lethal therapies for cancer: what's next after PARP inhibitors? |
| cord-268122-74nj66vb | Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing ALS- linked mutant SOD1 Region- specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis SIRT1 deacetylase in aging- induced neuromuscular degeneration and amyotrophic lateral sclerosis SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/ HSP70i chaperone system Differential sirtuin expression patterns in amyotrophic lateral sclerosis( ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS? |
| cord-268122-74nj66vb | Free Rad Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double- blind, placebo- controlled human pilot study Dietary metabolism, the gut microbiome, and heart failure Epidemiology and aetiology of heart failure Raising NAD in heart failure: time to translate? |
| cord-268122-74nj66vb | How, when, and where do human β- cells regenerate? |
| cord-268122-74nj66vb | NAD+/NADH balance regulate breast cancer progression Regulation of cancer cell metabolism Metastasis and oxidative stress: are antioxidants a metabolic driver of progression? |
| cord-268122-74nj66vb | SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis Could sirtuin activities modify ALS onset and progression? |
| cord-268122-74nj66vb | What is the crosstalk with the NAD+ systems of each organ? |
| cord-268122-74nj66vb | What is the distinct NAD+ metabolome in each tissue? |
| cord-268122-74nj66vb | Why do viruses cause cancer? |
| cord-268122-74nj66vb | a novel target for modulating NAD(+) homeostasis Is the enzyme ACMSD a novel therapeutic target in Parkinson's disease? |
| cord-268122-74nj66vb | how is alcohol metabolized by the body? |
| cord-268122-74nj66vb | signaling pathway Non- alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome Nicotinamide and NAFLD: is there nothing new under the Sun? |
| cord-265410-khwzdi79 | Bringing New Chemistry to Life Hachimoji DNA and RNA: A genetic system with eight building blocks Statistical physics of self- replication Dissipative adaptation in driven self- assembly Origins of life: A problem for physics, a key issues review Universal scaling across biochemical networks on Life is a verb What Is Life?: |
| cord-265410-khwzdi79 | By examining the Shinkansen and knowing nothing else, could one deduce the origin of the locomotive( a"metabolism"run by burning fossil fuels to boil water into steam,"compartmentalization"made of cast iron and wood, and"information processing"in the form of a human conductor)? |
| cord-265410-khwzdi79 | Can polarity- inverted membranes self- assemble on Titan? |
| cord-265410-khwzdi79 | For example, which pillars do viruses perform? |
| cord-265410-khwzdi79 | For instance, according to NASA's definition of life( Section 1), should a self- sustaining chemical system that is found evolving in a non- Darwinian fashion be considered"life as we do n't know it"or not alive at all? |
| cord-265410-khwzdi79 | How can evolution learn? |
| cord-265410-khwzdi79 | Life Likely Emerge on Earth in an RNA- First Process? |
| cord-265410-khwzdi79 | So, when investigating the emergence of life, what are we looking for if not specific biomolecules? |
| cord-265410-khwzdi79 | The Simple Organizing Seed of All Life? |
| cord-265410-khwzdi79 | The abiotic chemistry of thiolated acetate derivatives and the origin of life Are polyphosphates or phosphate esters prebiotic reagents? |
| cord-265410-khwzdi79 | Who Is Responsible for Abiogenesis? |
| cord-265410-khwzdi79 | Who is Responsible for Abiogenesis? |
| cord-265410-khwzdi79 | Why Is life? |
| cord-265410-khwzdi79 | Why could this process not be reversed to power a mechanotrophic organism? |
| cord-272050-0u62j7nj | For example, at what frequency is p88 used for cis- preferential replication of RNA1? |
| cord-272050-0u62j7nj | What does cis- preferential requirement for p88 in RNA1 replication means for RCNMV? |
| cord-271188-ewlxy5po | Does venesection reduce HIV viral load in patients with hereditary haemochromatosis? |
| cord-271241-w1q46y63 | Can We Contain the COVID-19 Outbreak With the Same Measures as for SARS? |
| cord-272579-aenuyht0 | the nucleolus- a gateway to viral infection? |
| cord-273326-gmw8gl2r | The crystal structure of Zika virus NS5 reveals conserved drug targets Antibody- dependent enhancement and zika: Real threat or phantom menace? |
| cord-273326-gmw8gl2r | Zika virus infection damages the testes in mice Zika virus infection of rhesus macaques leads to viral persistence in multiple tissues Zika virus: What have we learnt since the start of the recent epidemic? |
| cord-015394-uj7fe5y6 | : Do They Change during Pregnancy? |
| cord-015394-uj7fe5y6 | A Role for Intrahepatic GLUT1? |
| cord-015394-uj7fe5y6 | Androgens Influence Human Luteal Cells Function? |
| cord-015394-uj7fe5y6 | Are Contractions at 24- 32 weeks Gestation Less Painful Than Those at Full Term? |
| cord-015394-uj7fe5y6 | Could Confined Placental Mosaicism Account for Adverse Perinatal Outcomes in IVF Pregnancies? |
| cord-015394-uj7fe5y6 | Fact or Fiction? |
| cord-015394-uj7fe5y6 | Following Periconceptional Undernutrition or Twinning in Sheep? |
| cord-015394-uj7fe5y6 | In these experiments we sought to answer the question,'Does anandamide( AEA) work in the same manner as THC?' |
| cord-015394-uj7fe5y6 | Is There Evidence for Aromatase Activity in the Stroma of Postmenopausal Ovaries? |
| cord-015394-uj7fe5y6 | Is There a Role for Fatty Acids in the Pathogenesis of Pre- Eclampsia? |
| cord-015394-uj7fe5y6 | Is There a Seasonal Pattern in the Incidence of Post- Cesarean Endometritis? |
| cord-015394-uj7fe5y6 | Necessary? |
| cord-015394-uj7fe5y6 | Pregnancy Outcome? |
| cord-015394-uj7fe5y6 | Reason To Change Intrauterine Referral Practice in the Netherlands? |
| cord-015394-uj7fe5y6 | Term Preeclampsia: Any Risk for the Neonate? |
| cord-015394-uj7fe5y6 | and What Are the Roles Played by Peroxynitrite in Preeclamptic Women? |
| cord-271781-cfv0ta10 | ) TMPRSS2 and COVID-19: serendipity or opportunity for intervention? |
| cord-271781-cfv0ta10 | Detectable SARS- CoV-2 viral RNA in feces of three children during recovery period of COVID-19 pneumonia Detection of SARS- CoV-2 by RT- PCR in anal from patients who have recovered from coronavirus disease 2019 Isolation of 2019-nCoV from a stool specimen of a laboratory- confirmed case of the coronavirus disease Enteric involvement of coronaviruses: is faecal- oral transmission of SARS- CoV-2 possible? |
| cord-271781-cfv0ta10 | First confirmed detection of SARS- CoV-2 in untreated wastewater in Australia: a proof of concept for the wastewater surveillance of COVID-19 in the community Can SARS- CoV-2 infection be acquired in utero? |
| cord-273609-whm2ce4u | Betaactin- an unsuitable internal control for RT- PCR beta- Actin and GAPDH housekeeping gene expression in asthmatic airways is variable and not suitable for normalising mRNA levels GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues Control selection for RNA quantitation Direct comparison of GAPDH, beta- actin, cyclophilin, and 28S rRNA as internal standards for quantifying RNA levels under hypoxia Mechanical injury of cartilage explants causes specific time- dependent changes in chondrocyte gene expression Gene expression studies in prostate cancer tissue: which reference gene should be selected for normalization? |
| cord-274080-884x48on | Molecular mechanism of divalentmetal- induced activation of NS3 helicase and insights into Zika virus inhibitor design HCV infection by cell- to- cell transmission: choice or necessity? |
| cord-274080-884x48on | Novel ESCRT functions in cell biology: spiraling out of control? |
| cord-270892-ycc3csyh | Explanation and elaboration Ethnobotany and the search for new drugs: Ciba Foundation Symposium 185 Ethnobotany and natural products: The search for new molecules, new treatments of old diseases or a better understanding of indigenous cultures? |
| cord-270892-ycc3csyh | How contagious are common respiratory tract infections? |
| cord-270892-ycc3csyh | How scientific is the science in ethnopharmacology? |
| cord-272573-wxqly479 | As The Pandemic Spreads, Will There Be Enough Ventilators? |
| cord-272573-wxqly479 | In: GOV.UK[ Internet Google Docs Testing the efficacy of homemade masks: would they protect in an influenza pandemic? |
| cord-271504-t3y1w9ef | , its homologue ACE2 and neprilysin in angiotensin peptide metabolism COVID-19 and angiotensinconverting enzyme inhibitors and angiotensin receptor Blockers Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-271504-t3y1w9ef | : lessons from severe acute respiratory syndrome and Middle East respiratory syndrome Radiology of severe acute respiratory syndrome( SARS): the emerging pathologic- radiologic correlates of an emerging disease Middle East respiratory syndrome coronavirus: what does a radiologist need to know? |
| cord-271504-t3y1w9ef | A human monoclonal antibody blocking SARS- CoV-2 infection Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes IgM in microbial infections: taken for granted? |
| cord-271504-t3y1w9ef | The SARS- coronavirus papain- like protease: structure, function and inhibition by designed antiviral compounds Crystal Structures of the Main Peptidase from the SARS Coronavirus Inhibited by a Substrate- like Aza- peptide Epoxide Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry Protease inhibitors targeting coronavirus and filovirus entry Efficacy of camostat mesilate compared with famotidine for treatment of functional dyspepsia: is camostat mesilate effective? |
| cord-271504-t3y1w9ef | The broad- spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen Signatures of nucleotide analog incorporation by an RNA- dependent rna polymerase revealed using high- throughput magnetic tweezers Ribavirin in the treatment of SARS: a new trick for an old drug? |
| cord-271504-t3y1w9ef | What happens to people's lungs when they get coronavirus? |
| cord-277355-si3g5dih | Do deletions in CP also affect flaviviral virulence in vivo? |
| cord-275859-ix8du1er | If the local stability of 3- 4 bp is sufficient to determine frameshift efficiency, why does the HIV-1 frameshift site stem- loop contain 11 Watson- Crick base pairs? |
| cord-273910-fna7s9te | is CARD15 a susceptibility factor? |
| cord-275602-cog4nma0 | Why Indian? |
| cord-275602-cog4nma0 | why NDM-1? |
| cord-275252-4e3cn50u | Viruses, microRNAs and cancer RNA virus microRNA that mimics a B- cell oncomiR Viruses and microRNAs Virus- specific host miRNAs: antiviral defenses or promoters of persistent infection? |
| cord-275252-4e3cn50u | myocardial fibrosis and heart failure microRNAs in heart disease: putative novel therapeutic targets? |
| cord-274773-3jhka8wl | The first case of porcine epidemic diarrhea in Canada Does Circulating Antibody Play a Role in the Protection of Piglets against Porcine Epidemic Diarrhea Virus? |
| cord-272576-ez731lif | If a common directional change is observed, what types of changes likely reoccur in future epidemics caused by invasions from natural reservoir hosts? |
| cord-275307-d7htyfcl | Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells Global or local? |
| cord-273366-xd84f8ct | regulate double- stranded RNA- dependent protein kinase activation through a complex containing G3BP1 and Caprin1 Valiente- Echeverria, F. Who Regulates Whom? |
| cord-274663-zyzgk2z3 | Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs TDP-43: multiple targets, multiple disease mechanisms? |
| cord-276988-bvsz5q6d | A novel tumor- related long non- coding RNA The biogenesis, biology and characterization of circular RNAs Mis- splicing yields circular RNA molecules Cell- type specific features of circular RNA expression Selective release of circRNAs in platelet- derived extracellular vesicles Human platelets and their capacity of binding viruses: Meaning and challenges? |
| cord-276988-bvsz5q6d | However, the most intriguing question is: How and where do platelets get their content from? |
| cord-276988-bvsz5q6d | However, the most intriguing question is: How and where do platelets get their content from? |
| cord-276988-bvsz5q6d | In vitro generation of platelets: Where do we stand? |
| cord-276988-bvsz5q6d | Nevertheless, the biological relevance of platelet circRNAs, if any, remains unclear: do they modulate platelet functions or are they simply byproducts of megakaryocyte transcription and platelet mRNA degradation? |
| cord-276364-zyw5aukk | deranges dengue virion maturation Knockdown of autophagy enhances the innate immune response in hepatitis C virus- infected hepatocytes Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro Cholesterol manipulation by West Nile virus perturbs the cellular immune response Perturbation of intracellular cholesterol and fatty acid homeostasis during flavivirus infections Autophagy in cell death: an innocent convict? |
| cord-276493-hoaxv5e0 | a casepopulation study Anti- HCV, nucleotide inhibitors, repurposing against COVID-19 Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-264746-gfn312aa | & What is the chance of seeing a block of high G+C nucleotides shorter than 5000? |
| cord-264746-gfn312aa | ( e.g., is it likely for a block of high G+C to follow a block of low G+C?). |
| cord-264746-gfn312aa | 13.17? |
| cord-264746-gfn312aa | Do any of them have similar profiles? |
| cord-264746-gfn312aa | Furthermore, how does one select the scores for matches, mismatches, and indels? |
| cord-264746-gfn312aa | How does one determine which of the 129 possibilities is best? |
| cord-264746-gfn312aa | How large( or small) must the ratio be to say that the expression levels are really different?'' |
| cord-264746-gfn312aa | How long would it take to find the best alignment of two 1000 bp sequences by exhaustive search? |
| cord-264746-gfn312aa | How many chromosomes does it have? |
| cord-264746-gfn312aa | How many genes does it have? |
| cord-264746-gfn312aa | How many mammalian genomes have been completely sequenced? |
| cord-264746-gfn312aa | How many matches to that oligonucleotide would one expect to find in the human genome? |
| cord-264746-gfn312aa | How many possible proteins could be formed by a gene region containing four exons? |
| cord-264746-gfn312aa | How might this fact be used in gene finding algorithms? |
| cord-264746-gfn312aa | If each of the 13 SSR markers used by the FBI for identification purposes has 20 equally frequent alleles, what is the chance that two randomly chosen individuals have the same collection of alleles at those 13 markers? |
| cord-264746-gfn312aa | If one of these synonymous codons is energetically more efficient for the organism to use, what effect would that have on the organism's genome content? |
| cord-264746-gfn312aa | If the quantities are measured at the level of entire exons( e.g., did the algorithm correctly predict the location of the entire exon or not?), the values drop to around 70%. |
| cord-264746-gfn312aa | Phrased differently, would a ratio near 0.27 for spot 4 be likely if the experiment were repeated? |
| cord-264746-gfn312aa | The expression levels for two genes measured at four times are: implication of the correlation coefficient? |
| cord-264746-gfn312aa | This database makes it possible to take a query sequence and, for each of the 7500 families and their associated profile HMMs, ask the question,''Is the query sequence a member of this gene family?'' |
| cord-264746-gfn312aa | What are possible advantages and disadvantages of introns? |
| cord-264746-gfn312aa | What are they? |
| cord-264746-gfn312aa | What does the result tell you about zinc finger genes? |
| cord-264746-gfn312aa | What is the chance that a 20-nucleotide oligonucleotide matches a sequence other than the one it was designed to match? |
| cord-264746-gfn312aa | What is the length of the Drosphila melanogaster alcohol dehydrogenase gene? 9. |
| cord-264746-gfn312aa | What is the size of the Anopheles gambiae genome? |
| cord-277318-cwuls6xs | How then do translocating ribosomes unwind the downstream mRNA structure they encounter? |
| cord-277318-cwuls6xs | However, can such a condensed 1D projection capture the relevant thermodynamics and kinetics of the systems studied? |
| cord-277318-cwuls6xs | In other words, what makes a"good"reaction coordinate? |
| cord-274569-jh0dyyz7 | And second, would control of the levels and composition of secreted exosomes have associated functions? |
| cord-274569-jh0dyyz7 | And second, would control of the levels and composition of secreted exosomes have associated functions? |
| cord-274569-jh0dyyz7 | Causal or inconsequential? |
| cord-274569-jh0dyyz7 | First, can viral modulation of any of these regulators alter the content and levels of released exosomes? |
| cord-274569-jh0dyyz7 | First, can viral modulation of any of these regulators alter the content and levels of released exosomes? |
| cord-274569-jh0dyyz7 | gold- transferrin in rat reticulocytes: Demonstration of a pathway for receptor shedding Exosomes as divine messengers: Are they the hermes of modern molecular oncology? |
| cord-274569-jh0dyyz7 | soluble viral RNAs sorted into ILV? |
| cord-274569-jh0dyyz7 | soluble viral RNAs sorted into ILV? |
| cord-279070-cy049zbi | An enemy within? |
| cord-279070-cy049zbi | Secondly, the low G? |
| cord-276198-psjua913 | Does form meet function in the coronavirus replicative organelle? |
| cord-276198-psjua913 | Double- membrane organelles observed( x) or uncertainly observed(?) in infected cells are marked at right. |
| cord-276198-psjua913 | Secoviridae P ER V? |
| cord-278684-txlvla0j | Actions and mechanisms of action Natural and experimental Borna disease in animals Borna disease, a possible hazard for man? |
| cord-278684-txlvla0j | Borna disease virus: A possible etiologic factor for human affective disorders? |
| cord-274785-9jgg8ukr | Critical role of an antiviral stress granule containing RIG- I and PKR in viral detection and innate immunity Mechanistic insights into mammalian stress granule dynamics PACT, a stressmodulated cellular activator of interferon- induced doublestranded RNA- activated protein kinase, PKR Dynamic interaction of stress granules, DDX3X, and IKK- alpha mediates multiple functions in hepatitis C virus infection Who regulates whom? |
| cord-274785-9jgg8ukr | Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules Stress granules and processing bodies are dynamically linked sites of mRNP remodeling Real- time and quantitative imaging of mammalian stress granules and processing bodies Stress granules and cell signaling: more than just a passing phase? |
| cord-274785-9jgg8ukr | Further works are needed to address the following questions: First, is there any pathway to be a target for antiviral drug development? |
| cord-274785-9jgg8ukr | Second, do SG function as platforms that potentiate virus recognition? |
| cord-274785-9jgg8ukr | Third, is any unexplored pathway leading to SG formation which could be visualized by fluorescence in situ hybridization techniques- including single molecule RNA tracking methods in combination with super- resolution microscopy? |
| cord-274785-9jgg8ukr | Viral manipulation of PB may provide a better platform to understand this regulation;( 2) to determine which viral RNA species preferentially travel through these RNA granules and which ones do not? |
| cord-280048-b4dz1lnn | How could the problem we approached? |
| cord-279418-3r1ijafm | Endoplasmic Reticulum- Golgi Intermediate Compartment Membranes and Vimentin Filaments Participate in Vaccinia Virus Assembly Replication of African Swine Fever Virus DNA in Infected Cells Cytoplasmic Organization of POXvirus DNA Replication Aggresomes and Pericentriolar Sites of Virus Assembly: Cellular Defense or Viral Design? |
| cord-279418-3r1ijafm | This arrangement leads to the interaction of both( n+1) th Virus factories: associations of cell organelles for viral replication and morphogenesis Virus factories, double membrane vesicles and viroplasm generated in animal cells Virus factories: biogenesis and structural design Biomolecular condensates: organizers of cellular biochemistry Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/ Condensation Droplet organelles? |
| cord-275795-ee7qyw5h | Alpha- beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection Correlates of protective immunity in poxvirus infection: where does antibody stand? |
| cord-275795-ee7qyw5h | Circulating rotavirus- specific T cells have a poor functional profile Fulfilling the promise of rotavirus vaccines: how far have we come since licensure? |
| cord-275795-ee7qyw5h | Intracellular IFN- gamma expression in natural killer cells precedes lung CD8 þ T cell recruitment during respiratory syncytial virus infection HBV pathogenesis in animal models: recent advances on the role of platelets Basis of rabies virus neurovirulence in mice: expression of major histocompatibility complex class I and class II mRNAs Postlicensure effectiveness of varicella vaccine during an outbreak in a child care center Management of rabies in humans Vaccinia virus vaccines: past, present and future Hepatitis A virus in West Africa: is an epidemiological transition beginning? |
| cord-275795-ee7qyw5h | The T¼4 envelope of Sindbis virus is organized by interactions with a complementary T¼3 capsid Bystander target cell lysis and cytokine production by dengue virus- specific human CD4(þ) cytotoxic T- lymphocyte clones What is immune privilege( not)? |
| cord-275795-ee7qyw5h | The global burden of viral hepatitis from Analysis of T cell responses during active varicella- zoster virus reactivation in human ganglia REVIEW PAPER: pathology of animal models of alphavirus encephalitis Interview about immune privilege with Memory CD8 T cells in RSV infection: friend or foe? |
| cord-280795-wtrt13ij | Is it possible that a protein domain can participate in RNA replication while it is also responsible for the removal of 5′ γ- phosphate from the nascent RNA to allow cap structure formation? |
| cord-280795-wtrt13ij | Would it be possible that alanine substitution at Q826 affects not only the enzymatic activity but also the protein stability? |
| cord-279985-de0b27nq | Therapeutic vaccination against murine lymphoma by intratumoral injection of recombinant fowlpox virus encoding CD40 ligand Is cancer dangerous to the immune system? |
| cord-279985-de0b27nq | Vaccine- induced CD8+ central memory T cells in protection from simian AIDS Effector cytotoxic T lymphocyte numbers induced by vaccination should exceed levels in chronic infection for protection from HIV HIV- specific CD4+ T cells and viremia: who's in control? |
| cord-279623-ezax8c1u | A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response Large non- coding RNAs: missing links in cancer? |
| cord-281020-g1muealp | Are these sites further stabilized by interaction with viral and/or cellular proteins? |
| cord-281020-g1muealp | RNA viruses remodel pre- existing cellular membranes, as we generally assume, or do they actually build replication membranes de novo and thus can they be truly called''novel replication organelles''? |
| cord-281020-g1muealp | The apparently universal up- regulation of lipid metabolism by(+) RNA viruses raises interesting questions: Are the local changes in structural lipid composition the major driving force for formation of the membranous replication sites? |
| cord-278186-t3izmz6n | Targeting Toll- like receptors: emerging therapeutics? |
| cord-280003-ndpuezpo | Are there any meaningful differences between patients with short and long incubation period? |
| cord-280003-ndpuezpo | How many patients would raise antibody response and how long will the antibody convert to be positive since the exposure? |
| cord-280003-ndpuezpo | Is there any temporal association between the antibody response and the decline of viral load? |
| cord-280003-ndpuezpo | What are the sensitivities of antibody detection for patients in different illness stages? |
| cord-277830-6fsz9iy7 | The InterPro Database, 2003 brings increased coverage and new features Refinement of macromolecular structures by the maximum- likelihood method SCOP: a structural classification of proteins database for the investigation of sequences and structures Processing of X- ray diffraction data collected in oscillation mode Sequence requirements for RNA strand transfer during nidovirus discontinuous subgenomic RNA synthesis Precise excision of intervening sequences from precursor tRNAs by a membrane- associated yeast endonuclease MacroH2A, a core histone containing a large nonhistone region Evolutionary conservation of histone macroH2A subtypes and domains Coronavirus as a possible cause of severe acute respiratory syndrome Pre- tRNA splicing: variation on a theme or exception to the rule? |
| cord-278635-vwdxr1bl | A defective interfering influenza RNA inhibits infectious influenza virus replication in human respiratory tract cells: a potential new human antiviral Cell culture- based production of defective interfering particles for influenza antiviral therapy Influenza virus DI particles: Defective interfering or delightfully interesting? |
| cord-278635-vwdxr1bl | The defective component of viral populations Incomplete forms of influenza virus Functional characterization of naturally occurring variants of human hepatitis B virus containing the core internal deletion mutation Defective interfering viral particles in acute dengue infections Internally deleted WNV genomes isolated from exotic birds in New Mexico: function in cells, mosquitoes, and mice SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A( H7N9) virus infection Influenza defective interfering viral RNA is formed by internal deletion of genomic RNA Segment- specific noncoding sequences of the influenza virus genome RNA are involved in the specific competition between defective interfering RNA and its progenitor RNA segment at the virion assembly step Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad- spectrum antivirals? |
| cord-274097-11hvriqy | 23 Would the clinical picture resemble that of respiratory infection when parenterally transmitted? |
| cord-274097-11hvriqy | But what is our index of suspicion for recognition of TTD? |
| cord-274097-11hvriqy | COVID-19: what proportion are asymptomatic? |
| cord-274097-11hvriqy | Can we mine the electronic medical records of hospitalized COVID-19 patients and appropriate controls in high- incidence communities for a history of recent transfusion? |
| cord-274097-11hvriqy | How would we recognize it if it happened in the face of exponentially increasing caseloads in stressed acute health care venues? |
| cord-274097-11hvriqy | Is SARS‐CoV‐2 transfusion transmitted? |
| cord-274097-11hvriqy | So, what are our options? |
| cord-274097-11hvriqy | When there is no statistical association of transfusion with SARS- CoV infection would such information suffice to"prove"the negative? |
| cord-274097-11hvriqy | Would it enhance our approach to donor call- back for development of illness from 2 to 4 days to longer? |
| cord-280941-ds6x0yym | How will HPV vaccines affect cervical cancer? |
| cord-280941-ds6x0yym | The composition and the structure of bacterioferritin of Escherichia coli Self- assembly in the ferritin nano- cage protein superfamily Presenting native- like trimeric HIV-1 antigens with self- assembling nanoparticles Hemagglutinin- stem nanoparticles generate heterosubtypic influenza protection Ferritin nanocages: great potential as clinically translatable drug delivery vehicles? |
| cord-279691-v5kpmk0b | How are the nsps of CoVs able to induce the observed membrane rearrangements? |
| cord-282764-d9x1wii6 | The main question is why did the major glycosylation form of S TR2 protein lie in ∼115 kDa instead of ∼130 kDa? |
| cord-281174-3c1vue0y | Hybridization was performed at 41 8C with the fluorescein-11-dUTP labeled( 3? |
| cord-281174-3c1vue0y | The detector probe sequence is generic, provided by the NucliSens † Basic Kit, and complementary to the 3? |
| cord-281174-3c1vue0y | The specific capture probe used in this assay corresponded to the same NVInt probe used in RT- PCR hybridizations, except that it was 5? |
| cord-281174-3c1vue0y | b NVInt was 5? |
| cord-264884-ydkigome | ,, 2005? |
| cord-264884-ydkigome | A subset of human immunodefi ciency virus type 1 long- term nonprogressors is characterized by the unique presence of ancestral sequences in the viral population Does common architecture reveal a viral lineage spanning all three domains of life? |
| cord-264884-ydkigome | Accordingly, when contemplating the amazing complexity of the P1 immunity and how it evolved, Yarmolinsky posed the question;"Could the byzantine complexity of the controls at ImmI be the outcome, not of successive host- parasite accommodations, but of competition among related phages?" |
| cord-264884-ydkigome | Also, how do we defi ne information content or integrity of a consortia? |
| cord-264884-ydkigome | Can cooperation( or consortia behavior) result from any of these models? |
| cord-264884-ydkigome | Can this be considered an example of symbiosis in the accepted sense? |
| cord-264884-ydkigome | Could the adaptation to a host- specifi c persistence- based basal life strategy provide some explanations for the evolution of the higher fi delity RNA replicase of these coronaviruses? |
| cord-264884-ydkigome | DNA Viral eukaryogenesis: was the ancestor of the nucleus a complex DNA virus? |
| cord-264884-ydkigome | Did the need and selection for a larger genome override the use of error to generate adaptability as seen in poliovirus and HIV-1? |
| cord-264884-ydkigome | Does such a distributed pattern of evolution and gene novelty also apply to the phycodnaviruses? |
| cord-264884-ydkigome | Here a virus, there a virus, everywhere the same virus? |
| cord-264884-ydkigome | How can genetic complexity be created in such a circumstance? |
| cord-264884-ydkigome | How do we defi ne such fi tness since the mixture clearly matters? |
| cord-264884-ydkigome | How does MHV attain such stable and prevalent persistence in natural population yet retain the ability to cause disease in naive populations? |
| cord-264884-ydkigome | How generally important is this poliovirus in vivo quasispecies result? |
| cord-264884-ydkigome | How important are viruses in general to evolutionary biology? |
| cord-264884-ydkigome | How is information stability and higher fi tness attained with such errors? |
| cord-264884-ydkigome | How might such selection operate in natural populations? |
| cord-264884-ydkigome | How might we explain the increased fi delity and genome size of the nidoviruses? |
| cord-264884-ydkigome | How then do we link poxvirus evolution to other more ancient DNA viruses, such as PBCV-1 which has the same DNA replication mechanism, but distinct replication proteins? |
| cord-264884-ydkigome | If so, what selective pressures might have changed this seemingly basic feature? |
| cord-264884-ydkigome | If so, why is it that in sheep a distinctly different lineage of retrovirus( enJSRV) was also selected to provide a related placental function to a another mammal with signifi cantly different placental reproductive biology? |
| cord-264884-ydkigome | If we can accept the above conclusion concerning the role for viruses in the evolution of prokaryotes, we must then ask why such a successful evolutionary strategy was not apparently maintained in eukaryotes? |
| cord-264884-ydkigome | Is there any evidence that this result with poliovirus indeed represents a general virus- host evolutionary relationship in natural settings? |
| cord-264884-ydkigome | Protein repertoire of double- stranded DNA bacteriophages Characterization of the primary immunity region of the Escherichia coli linear plasmid prophage N15 Parvovirus variation for disease: a difference with RNA viruses? |
| cord-264884-ydkigome | Was there some change in viral adaptation in which quasispecies and generation of mixtures was no longer as important for adaptation? |
| cord-264884-ydkigome | Was this ERVL colonization of relevance to the ancient co- speciation of simian foamy virus and their primate host( Switzer et al., 2005)? |
| cord-264884-ydkigome | What could be more fascinating than a green sea slug- an animal that can use light for photosynthesis? |
| cord-264884-ydkigome | What do we know about the natural biology of these viruses, which might provide some insight into this? |
| cord-264884-ydkigome | What does structure tell us about virus evolution? |
| cord-264884-ydkigome | What exactly was the relevance of HERV endogenization to human survival and adaptations? |
| cord-264884-ydkigome | What is the fi tness consequence to the colony harboring MHV relative to its uninfected neighbor? |
| cord-264884-ydkigome | What maintains the MHV fi tness of natural persistence? |
| cord-264884-ydkigome | What then is the evolutionary relationship that links all of these seemingly distinct viruses? |
| cord-264884-ydkigome | What then is the fi tness and evolutionary consequence to E. coli harboring P1? |
| cord-264884-ydkigome | What was the role for SIV in the evolution of primate MHC( Vogel et al., 1999)? |
| cord-264884-ydkigome | Why is this relationship stable? |
| cord-264884-ydkigome | Why should prokaryotes and eukaryotes differ is such a fundamental way? |
| cord-264884-ydkigome | Why? |
| cord-264884-ydkigome | Why? |
| cord-264884-ydkigome | human and chimpanzee MHC I( Watkins, 1995; Kulski et al., 1999)? |
| cord-264884-ydkigome | tailed DNA bacteriophages Do viruses form lineages across different domains of life? |
| cord-281285-5g1rw202 | SARS- CoV-2, ACE2, and hydroxychloroquine: cardiovascular complications, therapeutics, and clinical readouts in the current settings Chloroquine or hydroxychloroquine for COVID-19: is cardiotoxicity a concern? |
| cord-285935-5rsk6g7l | How Far Are We? |
| cord-285290-l7mnq4yb | 'untranslated region directed blockers of iron- regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease Precise small- molecule recognition of a toxic CUG RNA repeat expansion Lead- and drug- like compounds: the rule- of- five revolution How drug- like are'ugly'drugs: do drug- likeness metrics predict ADME behaviour in humans? |
| cord-285290-l7mnq4yb | How many drug targets are there? |
| cord-285290-l7mnq4yb | Slow molecular recognition by RNA RNA recognition by Tat- derived peptides: interaction in the major groove? |
| cord-284076-087oltss | Targeted'knockdown'of channel expression in vivo with an antisense morpholino oligonucleotide Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models Molecular characterization of porcine reproductive and respiratory syndrome virus, a member of the arterivirus group Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication VP35 knockdown inhibits ebola virus amplification and protects against lethal infection in mice Inhibition of multiple subtypes of Influenza A virus in cell cultures with morpholino oligomers Morpholino oligos: making sense of antisense? |
| cord-278081-tk7vn1v1 | And what is the distribution and composition of RNAs and proteins in nucleolar fragments compared to intact nucleoli? |
| cord-278081-tk7vn1v1 | And, perhaps most important, what does this new hypothesis present as far as therapeutic targets? |
| cord-278081-tk7vn1v1 | For example, what is the effect of acetylated polyamines if they were to compete with spermidine and spermine in the nucleolar folding and assembly of RNPs? |
| cord-278081-tk7vn1v1 | Is it, for example, a conformational alteration of the ribosomal subunits stabilized by polyamines, or incomplete assembly of an RNP? |
| cord-278081-tk7vn1v1 | SSA/ Ro bound to misfolded RNAs stabilized with polyamines that prevent proper refolding? |
| cord-278081-tk7vn1v1 | What are the interactions and resulting structures of intronic Alu RNA with nucleolin? |
| cord-281385-oxohdfpu | GpppN- RNA);( iii) an N-7 methyltransferase( MTase) methylates the guanine N-7 position to produce m7GpppN- RNA( GpppN- RNA? m7GpppN);( iv) |
| cord-281385-oxohdfpu | MTase methylates the ribose 2 0-O position of the RNA to complete the type-1 cap formation( m7GpppN- RNA? |
| cord-281385-oxohdfpu | NS5 Live attenuated vaccine: the first clinically approved dengue vaccine? |
| cord-281385-oxohdfpu | an RNA triphosphatase removes the c- phosphate from the 5 0 triphosphate of the nascent RNA( pppN- RNA? ppN- RNA);( ii) an RNA guanylyltransferase( GTase) transfers the GMP moiety from GTP to ppN- RNA to generate GpppN- RNA( GTP+ ppN- RNA? |
| cord-281385-oxohdfpu | an RNA triphosphatase removes the c- phosphate from the 5 0 triphosphate of the nascent RNA( pppN- RNA? ppN- RNA);( ii) an RNA guanylyltransferase( GTase) transfers the GMP moiety from GTP to ppN- RNA to generate GpppN- RNA( GTP+ ppN- RNA? |
| cord-287093-9mertwj7 | Aggresomes resemble sites specialized for virus assembly Aggresomes and pericentriolar sites of virus assembly: cellular defense or viral design? |
| cord-287093-9mertwj7 | The human fatty acid synthase: a new therapeutic target for coxsackievirus B3-induced diseases? |
| cord-280427-smqc23vr | Are other species such as mosquitoes, houseflies responsible for the transmission of virus to humans? |
| cord-280427-smqc23vr | Are there any precautions to be taken with live animals or animal products? |
| cord-280427-smqc23vr | Can companion animals become infected with Covid-19? |
| cord-280427-smqc23vr | Can your pet get COVID-19? |
| cord-280427-smqc23vr | How to protect pets if you are sick? |
| cord-280427-smqc23vr | The role of environmental factors to transmission of SARS- CoV-2( COVID-19) Is COVID-19 the first pandemic that evolves into a panzootic? |
| cord-283132-rfw8njpo | A second question is what are the specific viral components which mediate ADE of infectivity for each virus? |
| cord-283132-rfw8njpo | Does the subclass of a given Ab determine whether it is able to mediate both neutralization and ADE of virus infectivity? |
| cord-283132-rfw8njpo | For instance, which receptors mediate ADE of virus infectivity? |
| cord-283132-rfw8njpo | Given the immune- mediated pathogenesis of FIP, what is the basis for protective immunity to FIPV infection? |
| cord-283132-rfw8njpo | IBV Do antibodies enhance the infection of cells by HIV? |
| cord-283132-rfw8njpo | Mechanistically, how does the binding of enhancing Ab to a particular epitope on a virus induce an increase in virus infectivity? |
| cord-283132-rfw8njpo | Will antibody- dependent enhancement of HIV-1 infection be a problem with AIDS vaccines Complement- mediated antibody- dependent enhancement of HIV-1 infection requires CD4 and complement receptors Antibody- dependent enhancement of human immunodeficiency virus type 1( HIV-1) infection in vitro by serum from HIV- l- infected and passively immunized chimpanzees Disease exacerbation caused by sequential dengue infections: myth or reality? |
| cord-283097-rlf5nv5q | Newcastle disease virus- vectored vaccines expressing the hemagglutinin or neuraminidase protein of H5N1 highly pathogenic avian influenza virus protect against virus challenge in monkeys Virulence of Newcastle disease virus: what is known so far? |
| cord-283097-rlf5nv5q | disease virus Use of reverse genetics to enhance the oncolytic properties of Newcastle disease virus Newcastle disease virus: an evolving pathogen? |
| cord-010092-uftc8inx | Can you confirm my genotype? cord-010092-uftc8inx Who is a blood donor recruiter?"was the topic of ABD- VII at 9- 11 March 2018. |
| cord-010092-uftc8inx | 4A- S18- 05 WHO IS SYPHILIS TESTING EXCLUDING? |
| cord-010092-uftc8inx | : IS IT TIME TO LABEL EACH UNIT WITH HB CONTENT? |
| cord-010092-uftc8inx | A donor was classified as"tired"if they responded"all the time"or"most of the time"to the question"how often do you feel that you lacked energy and strength?". |
| cord-010092-uftc8inx | ALL TOGETHER? |
| cord-010092-uftc8inx | Are we alone in the Universe? |
| cord-010092-uftc8inx | As a consequence, questions asked 30 years ago have changed: Today, molecular biologists looking at hundreds of newly discovered blood group alleles find themselves not being asked by serologists any more:"Can you confirm my serology?", but instead, pose their question to the experts for the blood group phenotype: |
| cord-010092-uftc8inx | But can we apply the metaphor as successfully into donating blood for research? |
| cord-010092-uftc8inx | Donors and Donation-Donor Adherence-are we doing the Right Thing? |
| cord-010092-uftc8inx | How can we start using this tool in unison with our existing tools to improve science and clinical practice in our respective( bio)medical fields? |
| cord-010092-uftc8inx | So is there a future for new anti- platelet agents? |
| cord-010092-uftc8inx | To evaluate self- rated health we used the well- validated single question:"How would you rate your health in general?". |
| cord-010092-uftc8inx | WHAT CAN WE LEARN FROM HOW ADVERSE EVENTS ARE DETECTED? |
| cord-010092-uftc8inx | What is the optimal balance between iron supplementation and prolongation of interdonation intervals? |
| cord-010092-uftc8inx | What then is the best approach to use? |
| cord-010092-uftc8inx | Where are we from? |
| cord-010092-uftc8inx | Where are we going? |
| cord-010092-uftc8inx | Will serologic typing be replaced by DNAbased typing? |
| cord-010092-uftc8inx | but how does this affect health? |
| cord-281565-v8s2ski3 | Role in Escherichia coli global regulation Control of bacterial nitrate assimilation by stabilization of G- quadruplex DNA Case studies on potential G- quadruplexforming sequences from the bacterial orders Deinococcales and Thermales derived from a survey of published genomes The Presence and Localization of G- Quadruplex Forming Sequences in the Domain of Bacteria RNA G- Quadruplex Structures Mediate Gene Regulation in Bacteria Structural polymorphism of the four- repeat Oxytricha nova telomeric DNA sequences G- Quadruplexes in Pathogens: A Common Route to Virulence Control? |
| cord-282618-tjvjlyn9 | HEK293 cells were transfected with NTC7485-EGFP( same backbone as NTC8485, except for kanR instead of RNA- OUT) and NTC7485-EGFP- modified to contain: VA1( PKR+RNAI+ADAR+inhibitor); VA1-PKR3( PKRÀRNAI+ADAR?inhibitor), in which VA1 incorporated the L3 point mutation, 26( the designation'ADAR?'was used, as the effect of L3 on ADAR inhibition has not been established); or VA1-PKR5( PKRÀRNAI+ADAR+inhibitor) in which VA1 incorporated a 1 bp change( pm91) in the central domain. |
| cord-281281-knelqmzx | A fight for supremacy Type 1 interferons and the virus- host relationship: A lesson in détente Viruses and Interferons Recent insights into emerging coronaviruses Clinical characteristics of coronavirus disease 2019 in China Coronavirus infections and immune responses Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis Complement as a target in COVID-19? |
| cord-281281-knelqmzx | Should we stimulate or suppress immune responses in COVID-19? |
| cord-287501-7it4kh0e | How can(-)-epigallocatechin gallate from green tea prevent HIV-1 infection? |
| cord-287501-7it4kh0e | The spike protein of SARS- CoV-a target for vaccine and therapeutic development Are drugs for SARS on the horizon? |
| cord-287501-7it4kh0e | genistein Effects of flavanoids on immune and inflammatory cell functions Metabolism of isoflavones in human subjects Flavonoids from carnation( Dianthus caryophyllus) and their antifungal activity Therapeutic potential of inhibition of the NF- κB pathway in the treatment of inflammation and cancer Antimicrobial activity of flavonoids Flavonoids: modulators of brain function? |
| cord-287153-jbuuph6w | How specific is too specific? |
| cord-287372-ya5uvoki | Clinical features of patients infected 705 with 2019 novel coronavirus in Wuhan A role for CT in COVID-19? |
| cord-287324-ecpicv5v | How severe and prevalent are Ebola and Marburg viruses? |
| cord-283439-hqdq2qrh | A novel coronavirus from patients with pneumonia in China Molecular evolution of human coronavirus genomes Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection Genome composition and divergence of the novel coronavirus( 2019-nCoV) originating in China Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Cryo- EM structure of the 2019-nCoV spike in the prefusion conformation Characterization of spike glycoprotein of SARS- CoV-2 on virus entry and its immune cross- reactivity with SARS- CoV Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques A crucial role of angiotensin converting enzyme 2( ACE2) in SARS coronavirus- induced lung injury Coronaviruses: an overview of their replication and pathogenesis Coronaviruses post- SARS: update on replication and pathogenesis Learning from the past: possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? |
| cord-283439-hqdq2qrh | Can Zn Be a Critical Element in COVID-19 Treatment? |
| cord-283439-hqdq2qrh | How to reduce the likelihood of coronavirus-19( CoV-19 or SARS- CoV-2) infection and lung inflammation mediated by IL-1 Correspondence a real- time dashboard A trial of lopinavir- ritonavir in adults hospitalized with severe Covid-19 Favipiravir versus Arbidol for COVID-19: a randomized clinical trial Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an openlabel non- randomized clinical trial A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 Personal view antiviral effects of chloroquine effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-283439-hqdq2qrh | beta coronavirus replication by a combination of interferon- alpha2b and ribavirin Coadministration of atazanavir- ritonavir and zinc sulfate: impact on hyperbilirubinemia and pharmacokinetics Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus( 2019-nCoV) in vitro The antiviral compound remdesivir potently inhibits RNAdependent RNA polymerase from Middle East respiratory syndrome coronavirus T-705( favipiravir) and related compounds: novel broad- spectrum inhibitors of RNA viral infections COVID-19 and chronological aging: senolytics and other anti- aging drugs for the treatment or prevention of corona virus infection? |
| cord-283439-hqdq2qrh | cord-283439-hqdq2qrh authors: Rahman, Mohammad Tariqur; Idid, Syed Zahir title: Can Zn Be a Critical Element in COVID-19 Treatment? |
| cord-287396-18p171nr | In a study by Flori and co- workers, the Qiagen- NRSP8 array was extended by adding probes for Pseudorabies Virus RNAs as well as probes for transcripts from the porcine Major Histocompatibility Complex, also called the Swine Leukocyte Antigen( SLA) complex, referred to as the Qiagen? |
| cord-287396-18p171nr | Whereas RNA- seq will sequence all transcripts containing poly- A? |
| cord-286298-pn9nwl64 | : What is the role of radiologists? |
| cord-286298-pn9nwl64 | Are aerosol, saliva, feces, urine, and foodborne the only routes of transmission? |
| cord-286298-pn9nwl64 | Can Chinese medicine be used for prevention of corona virus disease 2019( COVID-19)? |
| cord-286298-pn9nwl64 | Could Intravenous Immunoglobulin Collected from Recovered Coronavirus Patients Protect against COVID-19 and Strengthen the Immune System of New Patients? |
| cord-286298-pn9nwl64 | These unresolved questions include: What is the origin of SARS- CoV-2? |
| cord-286298-pn9nwl64 | What are the other unknown routes of transmission? |
| cord-286298-pn9nwl64 | What is the intermediate host that transmitted the virus from bats? |
| cord-286298-pn9nwl64 | Why does the virus cause severe disease and mortality in the elderly or those with co- morbidities, while it is milder in children? |
| cord-286298-pn9nwl64 | interferon signals in lung stromal cells protect from influenza virus infection Rescue fecal microbiota transplantation for antibiotic- associated diarrhea in critically ill patients Long- Term safety and efficacy of fecal microbiota transplant in active ulcerative colitis Microbiota and its role on viral evasion: Is it with us or against us? |
| cord-284609-1q75zw6b | Is the process limited to picornaviruses? |
| cord-284609-1q75zw6b | What purpose does RNA recombination serve? |
| cord-282742-eyukbot7 | Short RNAs that silence gene expression Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Pathogenesis of flavivirus infections: Using and abusing the host cell Mechanisms of posttranscriptional regulation by microRNAs: Are the answers in sight? |
| cord-282742-eyukbot7 | Target recognition and regulatory functions Control of arbovirus diseases: Is the vector the weak link? |
| cord-282742-eyukbot7 | genome Human cellular microRNA hsa- miR-29a interferes with viral nef protein expression and HIV-1 replication RNA interference mediated inhibition of dengue virus multiplication and entry in HepG2 cells Approaches for chemically synthesized siRNA and vector- mediated RNAi Effective siRNA targeting of the 3'untranslated region of the West Nile virus genome Use of RNA interference to prevent lethal murine west nile virus infection Yellow fever vaccine- How does it work and why do rare cases of serious adverse events take place? |
| cord-287466-ag5y781z | Black tiger breeding program yields record shrimp harvests in Australia Induction of antiviral immunity by double- stranded RNA in a marine invertebrate Double- stranded RNA induces sequence- specific antiviral silencing in addition to nonspecific immunity in a marine shrimp, convergence of RNA interference and innate immunity in the invertebrate antiviral response? |
| cord-287466-ag5y781z | Structure of newly found lymphoid organ Suppression of PmRab7 by dsRNA inhibits WSSV or YHV infection in shrimp Putative spawner- isolated mortality virus associated with mid- crop mortality syndrome in farmed Penaeus monodon from northern Australia Multiplex real- time PCR and high- resolution melting analysis for detection of white spot syndrome virus, yellow- head virus, and Penaeus monodon densovirus in penaeid shrimp Similarity between the histopathology of white spot syndrome virus and yellow head syndrome virus and its relevance to diagnosis of YHV disease in the Americas Latent yellow- head infections in Penaeus monodon and implications regarding disease resistance or tolerance Nidovirus transcription, how to make sense …? |
| cord-283998-whwksoxt | The latter is a complex of several noncovalently linked subunits( MW 2.5- 3.3 x lo'? |
| cord-278647-krh63hqp | A Two- year surveillance of 2009 pandemic influenza a( H1N1) in Guangzhou, China: from pandemic to seasonal influenza? |
| cord-278647-krh63hqp | Can reassortment explain these findings? |
| cord-278647-krh63hqp | Could H1N1 ever back- mutate into a strain such as the ancestral genotype that caused the catastrophic 1917- 1918 pandemic? |
| cord-278647-krh63hqp | Does mutation accumulation really have anything to do with virulence? |
| cord-278647-krh63hqp | In light of these findings, what are the medical implications? |
| cord-278647-krh63hqp | Is it feasible that natural selection might fail to remove a large number of deleterious mutations? |
| cord-278647-krh63hqp | Might pandemics be shortened by artificially accelerating the rate of genetic attenuation? |
| cord-278647-krh63hqp | Might the approximately 1,900 nucleotide substitutions be primarily attributed to the genetic drift of perfectly neutral variations? |
| cord-278647-krh63hqp | Might the observed divergence be primarily due to adaptive mutations? |
| cord-278647-krh63hqp | Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China RNA virus error catastrophe: direct molecular test by using ribavirin Implications of high RNA virus mutation rates: lethal mutagenesis and the antiviral drug ribavirin Ribavirin's antiviral mechanism of action: lethal mutagenesis? |
| cord-278647-krh63hqp | Reduction in mortality may be due to many other factors, including herd immunity, advances in medicine, and advances in hygiene, but would these other factors be expected to follow so tightly the time courses seen in Simonsen? |
| cord-278647-krh63hqp | There is abundant evidence for multiple substitutions in specific places that are, in turn, sites of active selection[ 42], but what about the rest of the genome? |
| cord-283880-lrrkuist | A novel rhabdovirus associated with acute hemorrhagic fever in central Africa Viral evolution: beyond drift and shift Rapid metagenomic identification of viral pathogens in clinical samples by real- time nanopore sequencing analysis Depletion of Abundant Sequences by Hybridization( DASH): using Cas9 to remove unwanted high- abundance species in sequencing libraries and molecular counting applications Viral metagenomics: are we missing the giants? |
| cord-283880-lrrkuist | a paradigm shift in evolutionary biology? |
| cord-289038-15yp9uqy | Where Does COVID-19 Stand? |
| cord-285262-690kpupt | Natural killer and lymphokine- activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells A cytomegalovirus- encoded inhibitor of apoptosis that suppresses caspase-8 activation Pseudomonas aeruginosa quorumsensing metabolite induces host immune cell death through cell surface lipid domain dissolution Murine cytomegalovirus IE3-dependent transcription is required for DAI/ ZBP1-mediated necroptosis Is receptor- interacting protein kinase 3 a viable therapeutic target for Mycobacterium tuberculosis infection? |
| cord-022940-atbjwpo5 | , What is the role of Ministry of Health? |
| cord-022940-atbjwpo5 | Are antibiotics against which the strain is resistant inducing the changes in bacterial proteome? |
| cord-022940-atbjwpo5 | Can YKL-40 be an inflammatory biomarker in vitamin D deficiency? |
| cord-022940-atbjwpo5 | Hemolysis and test rejection: are we following a reliable process? |
| cord-022940-atbjwpo5 | His- flag tag as a fusion partner in insect expression systemgain or loss? |
| cord-022940-atbjwpo5 | How does different lead levels affect TSH, FT3, FT4, vitamin B12 and folate? |
| cord-022940-atbjwpo5 | How preeclampsia affects oxidant status and antiinflammatory potential of breast milk? |
| cord-022940-atbjwpo5 | Is this strain characterized by other differences on a proteome level? |
| cord-022940-atbjwpo5 | It was intended to shed light on some questions such as, what is the place and importance of IVD in Turkey? |
| cord-022940-atbjwpo5 | MRM transitions used were m/ z? 250/164 for 8-iso- PGF 2a and m/ z? |
| cord-022940-atbjwpo5 | MRM transitions used were m/ z? 250/164 for 8-iso- PGF 2a and m/ z? |
| cord-022940-atbjwpo5 | Medical and biological illustrations for life sciences education: Is'a picture worth a thousand words'in visualizing medicine and science? |
| cord-022940-atbjwpo5 | P-04.01.1- 006 Host- pathogen interactions: is there a relationship between TLR 4 polymorphisms and tuberculosis in a group of Turkish patients? |
| cord-022940-atbjwpo5 | P-05.01.1- 015 Does causes 1800 MHz magnetic field application KRAS and P53 mutations in colon?: |
| cord-022940-atbjwpo5 | P-09.04.4- 108 Is there any relation between 50 g oral glucose challenge test and serum total oxidant- antioxidant status in pregnant woman? |
| cord-022940-atbjwpo5 | What are the responsibilities of educational institutions? |
| cord-022940-atbjwpo5 | What is extra to learn from protein drying measurements? |
| cord-286711-nr6vnl9h | What's in the name? |
| cord-288879-rj03dsib | This leads to the question: what possible functions could they serve for the virus itself or interaction with host cells? |
| cord-289407-8fje16z1 | ( SARS- CoV-2) from a symptomatic patient Environmental contamination by SARS CoV-2 in a designated hospital for coronavirus disease 2019 Environmental contamination of SARS- CoV-2 in healthcare premises Investigating SARS- CoV-2 surface and air contamination in an acute healthcare setting during the peak of the COVID-19 pandemic in London Are hygiene standards useful in assessing infection risk? |
| cord-289321-ahl46ql9 | In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms Complete replication of hepatitis C virus in cell culture Novel therapies for hepatitis C-one pill fits all? |
| cord-289321-ahl46ql9 | What does cis- dominant resistance mean mechanistically? |
| cord-286719-1xjmlwqr | Cytomegalovirus: pathogen, paradigm, and puzzle International consensus guidelines on the management of cytomegalovirus in solid organ transplantation Neonatal cytomegalovirus blood load and risk of sequelae in symptomatic and asymptomatic congenitally infected newborns Is HCMV a tumor promoter? |
| cord-285785-29ohzeug | How are circRNAs translated by non- canonical initiation mechanisms? |
| cord-286343-s8n1ldol | : What do we know? |
| cord-291749-revhbd0q | What do we know about ribosomal RNA methylation in Escherichia coli? |
| cord-290801-dv6aak01 | The 5 and 3 downstream AUG region elements are required for mosquito- borne flavivirus RNA replication RNA structures required for production of subgenomic flavivirus RNA La protein binds to NS5 and NS3 and to the 5 and 3 ends of Dengue 4 virus RNA Functional RNA elements in the dengue virus genome Autochthonous dengue fever in Croatia Impact of climate change and other factors on emerging arbovirus diseases Pathogenic flaviviruses Viral encephalomyelitis Origin and evolution of flavivirus 5 UTRs and panhandles: trans- terminal duplications? |
| cord-291026-99cit4ig | According to default S/ N thresholds, results were converted automatically to'+','À', or'?'and displayed on the screen at the end of the run. |
| cord-291026-99cit4ig | All samples tested gave either'+'or'À'result, with the exception of 5 ll of undiluted and unextracted serum, which all gave'?'results. |
| cord-291026-99cit4ig | No major secondary structures were found in the amplicon, based on prediction made by the MFOLD program( http://mfold.rna.albany.edu/? |
| cord-285505-8norumv6 | : What opportunity exists for a better nucleoside/ nucleotide to treat hepatitis C? |
| cord-285505-8norumv6 | In contrast, there was far less protection in clinical trials-why? |
| cord-285505-8norumv6 | Is it possible that raltegravir is inducing a single round of HIV replication, to give an increase in HIV circles? |
| cord-285505-8norumv6 | What is the role of T- cell responses? |
| cord-291513-vpehn6nx | Visualizations and statistical comparisons performed using PRISM 8.0 and the limit of detection determination were consistent with CDC recommendations whereby samples with a Ct value greater than Our experimental design sought to answer three primary questions: whether the e cacy of SARS- CoV-2 detection is in uenced by the following three variables: 1) does the swab storage solution( 95% EtOH vs 91% isopropanol) impact the sensitivity of detection; 2) which sample fraction, swab head or eluent, provides better detection delity; and 3) does the swab head material type matter? |
| cord-290254-m9l8ntur | The immunology of COVID-19: is immune modulation an option for treatment? |
| cord-290472-w77cmljm | Autoallergy: a pathogenetic factor in atopic dermatitis? |
| cord-290472-w77cmljm | Is it possible that diseases such as multiple sclerosis and asthma actually are caused by the coordinating effect of genetic susceptibility and, say, viral infection? |
| cord-290472-w77cmljm | The evolving role of mass spectrometry in cancer biomarker discovery RNA- Seq: a revolutionary tool for transcriptomics Comparative proteomics approach to screening of potential diagnostic and therapeutic targets for oral squamous cell carcinoma Asthma genetics: personalizing medicine Large- scale analysis of the yeast proteome by multidimensional protein identification technology Overcoming the dynamic range problem in mass spectrometry- based shotgun proteomics Autoantibodies as potential biomarkers for breast cancer Global analysis of protein activities using proteome chips Severe acute respiratory syndrome diagnostics using a coronavirus protein microarray ProCAT: a data analysis approach for protein microarrays Asthma and autoimmunity: is there a connection? |
| cord-290472-w77cmljm | Will we find that a disease associated with certain genetic markers also develops specific autoantibodies? |
| cord-290472-w77cmljm | mRNA? |
| cord-287487-qeltdch7 | Can MHV replicase proteins mediate high- fidelity replication without ExoN proofreading? |
| cord-287487-qeltdch7 | Can MHV replicase proteins mediate high- fidelity replication without ExoN proofreading? |
| cord-287487-qeltdch7 | In the face of selective pressure for increased fidelity, why did MHV- ExoN(-) not revert? |
| cord-287487-qeltdch7 | The role of mutational robustness in RNA virus evolution Plaques formed by mutagenized viral populations have elevated coinfection frequencies Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis Does mutational robustness inhibit extinction by lethal mutagenesis in viral populations? |
| cord-287487-qeltdch7 | Which mechanisms other than increased fidelity can compensate for the loss of proofreading? |
| cord-287487-qeltdch7 | Which mechanisms other than increased fidelity might account for MHV- ExoN(-) P250 nucleoside analog resistance? |
| cord-287487-qeltdch7 | hepatitis virus A59 mRNA 2: indications for RNA recombination between coronaviruses and influenza C virus Mouse hepatitis virus S RNA sequence reveals that nonstructural proteins ns4 and ns5a are not essential for murine coronavirus replication Luxury at a cost? |
| cord-287487-qeltdch7 | not revert? |
| cord-287487-qeltdch7 | nsp10 is a critical regulator of viral RNA synthesis Ribavirin's antiviral mechanism of action: lethal mutagenesis? |
| cord-287931-cxqzac4a | The terms at the family level that describe the host as a vertebrate animal were extracted from the"Virus Taxonomy List 2012"( http://ictvonline.org/virusTaxonomy.asp? |
| cord-290481-i2ppvsh5 | What could be the reason for multiplication of diverse suppressors in closteroviruses as opposed to single suppressors of smaller viruses? |
| cord-290481-i2ppvsh5 | What is the driving force behind the increase in viral genome complexity? |
| cord-290481-i2ppvsh5 | What is the functional significance of the increase in genome complexity seen in closteroviruses relative to the simpler plant viruses? |
| cord-290481-i2ppvsh5 | What would be considered an'environmental catastrophe'for a virus? |
| cord-290481-i2ppvsh5 | Why then the largest DNA viruses with the ∼1200 kb genomes are so much larger than the largest RNA viruses with the ∼30 kb genomes? |
| cord-290481-i2ppvsh5 | a titanic achievement? |
| cord-286603-4p3t0vre | Cellular proteostasis during influenza A virus infection- Friend or Foe? |
| cord-286603-4p3t0vre | unfolded protein response Hemagglutininneuraminidase and fusion proteins of virulent Newcastle disease virus cooperatively disturb fusion- fission homeostasis to enhance mitochondrial function by activating the unfolded protein response of endoplasmic reticulum and mitochondrial stress Mechanisms for enveloped virus budding: can some viruses do without an ESCRT? |
| cord-290948-cuu78cvl | The non- structural protein nsp10 of mouse hepatitis virus binds zinc ions and nucleic acids Discovery of an RNA virus 3 → 5 exoribonuclease that is critically involved in coronavirus RNA synthesis Nidovirus transcription: how to make sense? |
| cord-291965-9r9ll83m | What links bats to emerging infectious diseases? |
| cord-291063-de7v4e5s | Are viral- encoded microRNAs mediating latent HIV-1 infection? |
| cord-291063-de7v4e5s | LNA- mediated microRNA silencing in non- human primates Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses Silencing of microRNAs in vivo with'antagomirs Specificity, duplex degradation and subcellular localization of antagomirs Regulation of microRNA by antagomirs: a new class of pharmacological antagonists for the specific regulation of gene function? |
| cord-291063-de7v4e5s | Silencing Viral MicroRNA as a Novel Antiviral Therapy? |
| cord-291063-de7v4e5s | The properties and functions of virus encoded microRNA, siRNA, and other small noncoding RNAs Small RNAs: delivering the future Lentivirusmediated antagomir expression for specific inhibition of miRNA function Antisense, RNAi, and gene silencing strategies for therapy: mission possible or impossible? |
| cord-291063-de7v4e5s | ammunition to target miRNAs implicated in human disease? |
| cord-293747-ds8rhbkv | A Potentially Emerging Epidemic? |
| cord-288960-v6l6o5va | I interferon responses in vivo Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-?? |
| cord-288960-v6l6o5va | I interferon responses in vivo Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-?? |
| cord-288960-v6l6o5va | Recent approaches to intracellular delivery of drugs and dna and organelle targeting IFN?? |
| cord-288960-v6l6o5va | Recent approaches to intracellular delivery of drugs and dna and organelle targeting IFN?? |
| cord-288960-v6l6o5va | The regional function of cGAS/ STING signal in multiple organs: one of culprit behind systemic lupus erythematosus? |
| cord-288960-v6l6o5va | Type I interferon in the pathogenesis of lupus Type I interferon: friend or foe? |
| cord-288960-v6l6o5va | interferon responses are impaired in latently HIV infected cells HIV-1 and interferons: who's interfering with whom? |
| cord-288960-v6l6o5va | lessons learned from antagonism of STING signalling during RNA virus infection E2 proteins of high risk human papillomaviruses down- modulate STING and IFN-?? |
| cord-288960-v6l6o5va | lessons learned from antagonism of STING signalling during RNA virus infection E2 proteins of high risk human papillomaviruses down- modulate STING and IFN-?? |
| cord-293988-f5gvwjyh | An important question remains unanswered: did the cat actually die due to SARS- CoV-2 infection? |
| cord-285676-4kgy20o9 | Are replication and transcription distinct processes? |
| cord-285676-4kgy20o9 | Are they antagonists of the intracellular antiviral response or involved in host shut off? |
| cord-285676-4kgy20o9 | Is there a developmental shift from replication to transcription and if so, how is this regulated? |
| cord-285676-4kgy20o9 | What are the functions of the proteins derived from POL1b? |
| cord-285676-4kgy20o9 | What is the added value of the nonconserved POL1aderived cleavage products? |
| cord-285676-4kgy20o9 | What is the function of the various accessory genes of coronaviruses and how do they contribute to viral fitness? |
| cord-285676-4kgy20o9 | What then is the function of the leader sequence? |
| cord-285676-4kgy20o9 | and what are the consequences for replication and transcription? |
| cord-290218-dvyeg5fk | Will There Be a Cure for Ebola? |
| cord-292353-z86rjwle | : Variations on a theme? |
| cord-292353-z86rjwle | Are the 5'ends of influenza viral mRNAs synthesized in vivo donated by host mRNAs? |
| cord-292353-z86rjwle | Friend or foe in immunity to infection? |
| cord-293646-d4qcckh1 | The bicyclic lactam 22 is a mechanismbased inhibitor of HCV NS3 whilst additional examples of bis- benzimidazole derivatives that rely upon Zr?' |
| cord-291727-4wfhuvww | How is dual coding regulated? |
| cord-291727-4wfhuvww | In which cellular processes should we expect to see a high abundance of frameshifted proteins? |
| cord-291727-4wfhuvww | What is the identity of all dual- coding genes and out- of- frame proteins in the genome? |
| cord-291727-4wfhuvww | What is the sequence or structural motif for dual coding? |
| cord-292673-00s3wgem | over Ready to submit your research? |
| cord-289612-4x5t4c5u | Can you put a price on COVID-19 options? |
| cord-289612-4x5t4c5u | Nurs A conceptual model for the coronavirus disease 2019( COVID-19) outbreak in Wuhan, China with individual reaction and governmental action Diagnosis of the Coronavirus disease( COVID-19): rRT- PCR or CT? |
| cord-289612-4x5t4c5u | necessity or potentiality? |
| cord-289248-6mx4o0eb | have we learned? |
| cord-298847-szezd2vb | A light- and electronic- microscopic study Susceptibility of murine CNS to OC43 infection Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits Does viral disease underlie ALS? |
| cord-291590-24psoaer | Qatar Drivers of MERS- CoV transmission: what do we know? |
| cord-294363-bv6xa8v8 | what lessons have we learned? |
| cord-296309-i1mpov7k | 3 Control for stochastic sampling variation and qualitative sequencing error in next generation sequencing Tales from the crypt and coral reef: the successes and challenges of identifying new herpesviruses using metagenomics Human cancers and mammalian retroviruses: should we worry about bovine leukemia virus? |
| cord-296309-i1mpov7k | We will discuss the strengths, weaknesses and technical challenges of different viral WGS methods Why sequence whole genomes? |
| cord-296309-i1mpov7k | What does the future hold? |
| cord-296309-i1mpov7k | Why do we need deep sequencing? |
| cord-296309-i1mpov7k | benefit health now Clinical management of HIV-1 resistance HIV-1 genotypic drug resistance testing: digging deep, reaching wide? |
| cord-293913-frkb8iso | To address this possibility we asked the following question: If p72 is presented independently, will a viral proteinase domain recognize and cleave it to produce p65? |
| cord-293852-r72c6584 | Could interferon- gamma be a therapeutic target for treating heart failure? |
| cord-293852-r72c6584 | Fatal Severe Acute Respiratory Syndrome is Associated with Multiorgan Involvement by Coronavirus Quantitative temporal- spatial distribution of severe acute respiratory syndromeassociated coronavirus( SARS- CoV) in post- mortem tissues SARS- coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS Preventing a Covid-19 Pandemic SARS- CoV2: should Inhibitors of the Renin- Angiotensin System be Withdrawn in Patients with COVID-19? |
| cord-293852-r72c6584 | Noncoding RNAs regulating inflammation and the cardiovascular system: are they playing a role in COVID-19? |
| cord-293852-r72c6584 | over Ready to submit your research? |
| cord-297323-l3f12hg4 | A Multibasic Cleavage Site in the Spike Protein of SARS- CoV-2 Is Essential for Infection of Human Lung Cells Clinical and immunologic features in severe and moderate Coronavirus Disease Asymptomatic carriage and transmission of SARS- CoV-2: What do we know? |
| cord-297323-l3f12hg4 | Reduced dynamic range of antiviral innate immune responses in aging Oxidative stress, inflamm- aging and immunosenescence Genomewide Association Study of Severe Covid-19 with Respiratory Failure Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging? |
| cord-297323-l3f12hg4 | Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection COVID-19 as a STING disorder with delayed over- secretion of interferon- beta Activated STING in a Vascular and Pulmonary Syndrome Dampened STING- Dependent Interferon Activation in Bats Pathogenic role of HMGB1 in SARS? |
| cord-295351-0zr2e8lh | : why is this situation a PHEIC? |
| cord-293790-7hyelm88 | Given the involvement of autophagy at the site of replication of other positive- stranded RNA viruses, are the autophagy proteins or structure involved in HCV replication? |
| cord-294800-akr4f5p8 | : what's next? |
| cord-294800-akr4f5p8 | Can Chinese medicine be used for prevention of corona virus disease 2019( COVID-19)? |
| cord-294800-akr4f5p8 | Teicoplanin: an alternative drug for the treatment of COVID-19? |
| cord-294800-akr4f5p8 | The FDA- approved drug ivermectin inhibits the replication of SARS- CoV-2 in vitro Nuclear trafficking of proteins from RNA viruses: potential target for antivirals? |
| cord-294800-akr4f5p8 | The mercurial nature of neutrophils: still an enigma in ARDS? |
| cord-294800-akr4f5p8 | a retrospective cohort study Characterization of SARS- CoV- specific memory T cells from recovered individuals 4 years after infection Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-294800-akr4f5p8 | emergence and implications for emergency care Enteric involvement of coronaviruses: is faecal- oral transmission of SARS- CoV-2 possible? |
| cord-291225-75ys908n | do sigma viruses walk alone? |
| cord-300884-rqfxe0x1 | The papain- like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme Full- length human immunodeficiency virus type 1 genomes from subtype C- infected seroconverters in India, with evidence of intersubtype recombination A biochemical genomics approach for identifying genes by the activity of their products Localization of an RNA- binding domain in the nucleocapsid protein of the coronavirus mouse hepatitis virus Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure Discovery of an RNA virus 3′→5′ exoribonuclease that is critically involved in coronavirus RNA synthesis Characterization of the coronavirus M protein and nucleocapsid interaction in infected cells Characterization of N protein selfassociation in coronavirus ribonucleoprotein complexes Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites Nidovirus transcription: how to make sense …? |
| cord-291916-5yqc3zcx | Are they closely related? |
| cord-291916-5yqc3zcx | New evidence for an old therapeutic tool? |
| cord-291916-5yqc3zcx | The Allplex 2019-nCoV( Seegene) assay: Which performances are for SARS- CoV-2 infection diagnosis? |
| cord-291916-5yqc3zcx | The epidemiology and pathogenesis of coronavirus disease( COVID-19) outbreak Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents Enteric involvement of coronaviruses: Is faecal- oral transmission of SARS- CoV-2 possible? |
| cord-291916-5yqc3zcx | What we know? |
| cord-291916-5yqc3zcx | cyclin G- associated kinase regulate hepatitis C virus entry and are potential drug targets Effects of chloroquine on viral infections: An old drug against today's diseases? |
| cord-287758-da11ypiy | ( COVID-19) Clinically Significant Drug Interactions with Cyclosporin Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/ Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus( MERS- CoV), and Severe Acute Respiratory Syndrome Coronavirus( SARS- CoV) Discovery and development of safe- in- man broadspectrum antiviral agents Teicoplanin: an alternative drug for the treatment of COVID-19? |
| cord-287758-da11ypiy | : cord-287758-da11ypiy authors: Mônica Vitalino de Almeida, Sinara; Cleberson Santos Soares, José; Lima dos Santos, Keriolaine; Emanuel Ferreira Alves, Josival; Galdino Ribeiro, Amélia; Trindade Tenório Jacob, Íris; Juliane da Silva Ferreira, Cindy; Celerino dos Santos, Jéssica; Ferreira de Oliveira, Jamerson; Bezerra de Carvalho Junior, Luiz; do Carmo Alves de Lima, Maria title: COVID-19 therapy: what weapons do we bring into battle? |
| cord-287758-da11ypiy | A Review of Its Use in the Management of HIV-1 Infection Discovering drugs to treat coronavirus disease 2019( COVID-19) Therapeutic Options and Critical Care Strategies in COVID-19 Patients; Where Do We Stand in This Battle? |
| cord-287758-da11ypiy | A new trick for an old drug? |
| cord-287758-da11ypiy | Antiviral treatment of COVID-19 Hydroxychloroquine and ivermectin: A synergistic combination for COVID-19 chemoprophylaxis and treatment? |
| cord-287758-da11ypiy | Clinical course and outcomes of critically ill patients with SARS- CoV-2 pneumonia in Wuhan, China: a single- centered, retrospective, observational study Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-287758-da11ypiy | Engineering an antiviral for COVID-19? |
| cord-287758-da11ypiy | How Far Are We? |
| cord-287758-da11ypiy | The Use of Cyclosporine A in Rheumatology: a 2016 Comprehensive Review Cyclosporine A: a valid candidate to treat COVID-19 patients with acute respiratory failure? |
| cord-287758-da11ypiy | The possible mechanisms of action of 4-aminoquinolines( chloroquine/ hydroxychloroquine) against Sars- Cov-2 infection( COVID-19): A role for iron homeostasis? |
| cord-287758-da11ypiy | The world is facing a huge challenge in the coronavirus disease( COVID-19) pandemic: How to fight an enemy without weapons in terms of therapy? |
| cord-297078-pxggjaby | Did DNA replication evolve twice independently? |
| cord-297078-pxggjaby | Early evolution: prokaryotes, the new kids on the block Methyl- RNA: an evolutionary bridge between RNA and DNA? |
| cord-297078-pxggjaby | On one hand the late stages of the RNP world appear complex, so how could a small RNA genome have supported both protein synthesis and have evolved enzymes as chemically''sophisticated''as ribonucleotide reductases( Poole, Penny, and Sjöberg 2000)? |
| cord-297078-pxggjaby | On the other hand, how feasible is the contention that the LUCA had an RNA genome? |
| cord-297078-pxggjaby | The third is somewhat dependent on the first; assuming RNA repair was present, was it involved in quality control, genome replication, or both? |
| cord-297078-pxggjaby | mRNA Proofreading and Repair: Clues that the Last Universal Common Ancestor Possessed an RNA Genome? |
| cord-294592-zwvr57a0 | A new key player in virus- host interactions? |
| cord-292983-msuluuuu | 7 Papers of particular interest, published within the period of review, have been highlighted as of special interest of outstanding interest DNA vaccines: ready for prime time? |
| cord-292983-msuluuuu | DNA vaccines- how far from clinical use? |
| cord-295019-8tf8ah6g | A novel mammalian cell- based approach for the discovery of anticancer drugs with reduced cytotoxicity on non- dividing cells Drug discovery and natural products: end of an era or an endless frontier? |
| cord-295019-8tf8ah6g | is subcellular localization the answer? |
| cord-300399-21xozruq | Eurosurveillance Comparative performance of SARS- CoV-2 detection assays using seven different primer- probe sets and one assay kit How to choose the right real- time RT- PCR primer sets for the SARS- CoV-2 genome detection? |
| cord-299747-qovrstak | What are the main challenges to designing and optimizing new inhibitors of non- HCV positive- strand RNA viruses? |
| cord-292416-3hhi4wps | The next outbreak? |
| cord-292416-3hhi4wps | what can they teach us about the severe acute respiratory syndrome? |
| cord-296250-7ln7p715 | An AlphaScreen ®-based assay for high- throughput screening for specific inhibitors of nuclear import Nuclear trafficking of proteins from RNA viruses: potential target for antivirals? |
| cord-296250-7ln7p715 | International Scientific and Technical Committee Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital Meta- analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? |
| cord-299754-tgexahwd | Do TRIM proteins function as hubs connecting different signaling pathways or different systems? |
| cord-299754-tgexahwd | For example, how many TRIMs act as autophagic receptors and what are their specific targets? |
| cord-299754-tgexahwd | How is the autophagic role of TRIMs integrated with the other functions of TRIMs, including regulation of gene expression and pro- inflammatory signaling? |
| cord-299754-tgexahwd | I interferons in infectious disease Are the IKKs and IKK- related kinases TBK1 and IKK- epsilon similarly activated? |
| cord-299754-tgexahwd | What is the interplay between the E3 ligase activity of TRIMs and precision autophagy? |
| cord-292347-d7xq7x5g | Scalable, semi- automated fluorescence reduction neutralization assay 861 samples Diagnosis of Corona Virus Disease Announced the Development of a SARS-886 Analysis of serologic cross- reactivity between common human 889-2 using coronavirus antigen microarray Sensitive and specific monoclonal antibody- based capture enzyme 897 Diagnosis of Acute Respiratory Syndrome Coronavirus 2 903 Infection by Detection of Nucleocapsid Protein Chemiluminescent immunometric detection 906 of SARS- CoV in sera as an early marker for the diagnosis of SARS Standard coronavirus test, if available, works 910 well � but can new diagnostics help in this pandemic? |
| cord-292347-d7xq7x5g | What is CRISPR? |
| cord-300023-2dg7njki | How long do nosocomial pathogens persist on inanimate surfaces? |
| cord-297579-ohpm5ys0 | Where are we now? |
| cord-297579-ohpm5ys0 | ribavirin effectively inhibit Norwalk virus replication in replicon- bearing cells Crystal structures of murine norovirus-1 RNA- dependent RNA polymerase in complex with 2-thiouridine or ribavirin Mechanism of action of interferon and ribavirin in treatment of hepatitis C Ribavirin's antiviral mechanism of action: lethal mutagenesis? |
| cord-297092-oq14cwka | An update on an emerging and re- emerging viral disease of swine The natural history of porcine circovirus type 2: From an inoffensive virus to a devastating swine disease? |
| cord-297092-oq14cwka | Are RNA viruses candidate agents for the next global pandemic? |
| cord-297092-oq14cwka | The first detection of Senecavirus A in pigs in Thailand Senecavirus A: An Emerging Pathogen Causing Vesicular Disease and Mortality in Pigs? |
| cord-297092-oq14cwka | What's in my pot? |
| cord-298938-xemarhlv | Cleavage of the divergent domains of ribosomal RNA in apoptosis Chronic hepatitis A with persistent viral replication Replication of hepatitis A viruses with chimeric 5 nontranslated regions 70 Specific proteolytic cleavage of poly(ADP- ribose) polymerase- an early marker of chemotherapy- induced apoptosis Cleavage of poly( A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff? |
| cord-298938-xemarhlv | Fine mapping of 28S rRNA sites specifically cleaved in cells undergoing apoptosis Divergence towards a dead end? |
| cord-300963-1n1f8mf2 | Could patients with inflammatory bowel disease treated with immunomodulators or biologics be at lower risk for severe forms of covid-19? |
| cord-300963-1n1f8mf2 | recent insights into emerging coronaviruses Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology A pneumonia outbreak associated with a new coronavirus of probable bat origin Profile of specific antibodies to the SARSassociated coronavirus Pathological findings of COVID-19 associated with acute respiratory distress syndrome Are patients with inflammatory bowel disease at increased risk for Covid-19 infection? |
| cord-297039-vfuem6bk | How are circRNAs translated by non- canonical initiation mechanisms? |
| cord-297880-jlnv90vn | Nidovirus transcription: how to make sense? |
| cord-297880-jlnv90vn | What is the function of U1 and U2? |
| cord-297880-jlnv90vn | cause abnormalities in ribosome profiling experiments Insights into the mechanisms of eukaryotic translation gained with ribosome profiling PAML 4: phylogenetic analysis by maximum likelihood Detecting overlapping coding sequences in virus genomes A case for a CUG- initiated coding sequence overlapping torovirus ORF1a and encoding a novel 30 kDa product Origins of genes:"big bang"or continuous creation? |
| cord-297760-uzzuoy9v | Rational siRNA design for RNA interference An algorithm for selection of functional siRNA sequences Noise amidst the silence: off- target effects of siRNAs? |
| cord-298905-c2uuvfm5 | Is phosphatidyl- serine a VSV- binding site? |
| cord-298905-c2uuvfm5 | the acetylcholine receptor a rabies virus receptor? |
| cord-297790-tpjxt0w5 | A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-297790-tpjxt0w5 | A molecular phylogeny for bats illuminates biogeography and the fossil record Host and viral traits predict zoonotic spillover from mammals Are disease reservoirs special? |
| cord-297790-tpjxt0w5 | Are bats exceptional viral reservoirs? |
| cord-297790-tpjxt0w5 | Do our life history traits make us susceptible to generating damaging immune responses to RNA viruses or does the physiology of bats make them particularly tolerant or resistant? |
| cord-297790-tpjxt0w5 | Mass extinctions, biodiversity and mitochondrial function: are bats'special'as reservoirs for emerging viruses? |
| cord-297790-tpjxt0w5 | What links bats to emerging infectious diseases? |
| cord-298820-nogoqyxl | Cytomegaloviruses use multiple mechanisms to elude the host immune response Where, O death, is thy sting? |
| cord-289535-srrfr1es | CD8+ T- cell responses after rAd5 boost in a randomized clinical trial BCG- induced trained immunity: can it offer protection against COVID-19? |
| cord-289535-srrfr1es | Can existing live vaccines prevent COVID-19? |
| cord-289535-srrfr1es | Could an unrelated live attenuated vaccine serve as a preventive measure to dampen septic inflammation associated with COVID-19 infection? |
| cord-289535-srrfr1es | How immune T- cell augmentation can help prevent COVID-19: a possible nutritional solution using ketogenic lifestyle jri/ vol4without altering disease transmission work? |
| cord-289535-srrfr1es | How to achieve equitable global distribution? |
| cord-289535-srrfr1es | Is human challenge part of the pathway to a licensed product? |
| cord-289535-srrfr1es | Is there an ideal animal model for SARS? |
| cord-289535-srrfr1es | Mammalian microRNAs predominantly act to decrease target mRNA levels AU- rich elements and associated factors: are there unifying principles? |
| cord-289535-srrfr1es | Nonspecific protection of mice against influenza virus infection by local or systemic immunization with bacille Calmette- Guerin Is global BCG vaccination coverage relevant to the progression of SARS- CoV-2 pandemic? |
| cord-289535-srrfr1es | What is the risk of immunopathology? |
| cord-289535-srrfr1es | Why Norwood? |
| cord-298281-wkje5jyt | : Importance of the awareness of the clinical syndrome by urologists Structure analysis of the receptor binding of 2019-nCoV ACE2 Expression in kidney and testis may cause kidney and testis damage after 2019-nCoV infection Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses Single- cell RNA- seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single- cell transcriptome analysis Case report of COVID-19 in a kidney transplant recipient: does immunosuppression alter the clinical presentation? |
| cord-298281-wkje5jyt | China Identification of kidney transplant recipients with coronavirus disease 2019 COVID-19 in a kidney transplant patient Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-298233-qqhgmqrg | ADP- ribose-1"-phosphate dephosphorylation by a conserved domain of nsP3 Assessment of the cross- protective capability of recombinant capsid proteins derived from pig, rat, and avian hepatitis E viruses( HEV) against challenge with a genotype 3 HEV in pigs Is hepatitis E virus an emerging problem in industrialized countries? |
| cord-298233-qqhgmqrg | Does chronic hepatitis E virus infection exist in immunocompetent patients? |
| cord-298233-qqhgmqrg | interacts with the Bbeta chain of fibrinogen resulting in decreased fibrinogen secretion from HuH-7 cells Subcellular localization of hepatitis E virus( HEV) replicase Molecular organization and replication of hepatitis E virus( HEV) Isolation of a cDNA from the virus responsible for enterically transmitted non- A, non- B hepatitis Structural characterization of recombinant hepatitis E virus ORF2 proteins in baculovirus- infected insect cells New models of hepatitis E virus replication in human and porcine hepatocyte cell lines Expression of the hepatitis E virus ORF1 Conservation of the putative methyltransferase domain: a hallmark of the'Sindbis- like'supergroup of positive- strand RNA viruses UK acquired hepatitis E- An emerging problem? |
| cord-302368-uhhtvdif | What then are some of the benefits of a selectively labeled sample when uniformly labeled samples have been shown to be adequate? |
| cord-304306-rxjahqwh | Structural Differences Linked to Virus Characteristics? |
| cord-301362-f3lp10lm | The molecular pathogenesis of Semliki Forest virus: a model virus made useful? |
| cord-294260-g410mavp | How is it determined at which B- TRS the synthesis of the( −) strand RNA stalls, leading to duplex formation with an L- TRS? |
| cord-294260-g410mavp | The stability of the duplex between sense and antisense transcription- regulating sequences is a crucial factor in arterivirussubgenomic mRNA synthesis Nidovirus transcription: how to make sense …? |
| cord-294260-g410mavp | With respect to viruses with multiple SG RNAs, why are some RNAs made in larger amounts than others? |
| cord-303319-v3iyur78 | The interferon response to intracellular DNA: why so many receptors? |
| cord-302195-25gjbyi1 | : what is its fate in urban water cycle and how can the water research community respond? |
| cord-302195-25gjbyi1 | First? |
| cord-302195-25gjbyi1 | Regressing SARS- CoV-2 sewage measurements onto COVID-19 burden in the population: a proof- of- concept for quantitative environmental surveillance Higher virulence of COVID-19 in the air- polluted regions of eight severely affected countries Clinical progression and viral load in a community outbreak of coronavirus- associated SARS pneumonia: a prospective study Editorial Perspectives: will SARS- CoV-2 reset public health requirements in the water industry? |
| cord-303189-ktl4jw8v | The interferon response to intracellular DNA: why so many receptors? |
| cord-302895-471zei5o | Nidovirus helicase: a role in post- transcriptional quality control of viral mRNAs? |
| cord-302895-471zei5o | The nsp10 C- terminal domain: coupling ATPase and helicase activities? |
| cord-304058-i8cywew0 | The large 386-nt deletion in SARS- associated coronavirus: evidence for quasispecies? |
| cord-304058-i8cywew0 | what can they teach us about the severe acute respiratory syndrome? |
| cord-302047-vv5gpldi | : What Have we Learned? |
| cord-302047-vv5gpldi | First, how stable are natural virus genomes, and under what conditions do they become unstable? |
| cord-302047-vv5gpldi | Second, since horizontal gene transfer( HGT) plays an important role in virus evolution, under what conditions are transferred sequences likely to be retained? |
| cord-305591-ir3wz6nr | Quadruplex DNA: sequence, topology and structure G- quadruplexes and their regulatory roles in biology G- quadruplexes in pathogens: a common route to virulence control? |
| cord-305591-ir3wz6nr | The folding of 5'-UTR human G- quadruplexes possessing a long central loop How long is too long? |
| cord-307860-iqk1yiw4 | Emergence of novel coronavirus and COVID-19: whether to stay or die out? |
| cord-307860-iqk1yiw4 | Why is COVID-19 so mild in children? |
| cord-308034-9b219k0v | A ribozyme at heart? |
| cord-305290-xnjwv0d7 | Belcourt, M. F., and Farabaugh, I? J.( 1990). |
| cord-305290-xnjwv0d7 | Chang, L.-J., Pryciak, t?, Ganem, D.. and Varmus, H. E.( 1989. |
| cord-307934-84zfabti | Trojan exosomes riding the Trojan horse? |
| cord-305811-987dhnf7 | However, moving the cis- acting attenuator hairpin 59 further reduced its 21 frameshifting attenuation activity( Fig. 5), whereas moving the internal SD? |
| cord-305811-987dhnf7 | In this context, SD? anti- SD duplex formation has been shown to change the mRNA exit channel pathway and create numerous ribosomal interactions[ 26]. |
| cord-305811-987dhnf7 | Interestingly, both the in- cis acting hairpin revealed here and the internal SD? |
| cord-305811-987dhnf7 | It will be interesting to see if an in- cis acting RNA hairpin can replace the functionality of internal SD? |
| cord-306535-j26eqmxt | Isolation and morphological characterization Integrative characterization of germ cell- specific genes from mouse spermatocyte UniGene library Comparative and functional analysis of testis- specific genes Genome engineering uncovers 54 evolutionarily conserved and testis- enriched genes that are not required for male fertility in mice Reaching for high- hanging fruit in drug discovery at protein- protein interfaces Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation Catalytic in vivo protein knockdown by small- molecule PROTACs Hijacking the E3 ubiquitin ligase cereblon to efficiently target BRD4 Lessons in PROTAC design from selective degradation with a promiscuous warhead Assessing different E3 ligases for small molecule induced protein ubiquitination and degradation Cell- penetrating peptides: 20 years later, where do we stand? |
| cord-306076-ygfnkgqp | An option for the future? |
| cord-306076-ygfnkgqp | expression profiling in mild asthmatic human airways and effect of corticosteroid therapy MicroRNAs in inflammatory lung disease-- master regulators or target practice? |
| cord-307354-dkwcheu0 | virion host shutoff RNase is enabled by pUL47 and an embedded nuclear export signal and defines the sites of degradation of AU- rich and stable cellular mRNAs Viral phosphodiesterases that antagonize doublestranded RNA signaling to RNase L by degrading 2- 5A Human genome- wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis Herpes simplex virus virion host shutoff protein: immune evasion mediated by a viral RNase? |
| cord-304283-nv4ret1f | Matrilysin( matrix metalloproteinase-7): a new promising drug target in cancer and inflammation? |
| cord-310141-2jofy8fo | Antiviral RNAi therapy: emerging approaches for hitting a moving target Nucleic acids- based therapeutics in the battle against pathogenic viruses RNAi: the nuts and bolts of the RISC machine RNA interference: new mechanisms for targeted treatment? |
| cord-310141-2jofy8fo | how many mechanisms? |
| cord-310141-2jofy8fo | nude mice Filoviridae: a taxonomic home for Marburg and Ebola viruses? |
| cord-306921-3afgpunj | -what is the evidence for causation? |
| cord-304553-gbwb7fqi | A cure for bioterrorism? |
| cord-304553-gbwb7fqi | Avian influenza virus infections in humans Seed viruses containing novel avian HA and NA antigens for prevention against potential influenza pandemic Antiviral chemotherapeutic agents against respiratory viruses: where are we now and what's in the pipeline? |
| cord-304553-gbwb7fqi | Do DNA vaccines induce autoimmune disease? |
| cord-304553-gbwb7fqi | Macrophages secrete a novel heparin- binding protein with inflammatory and neutrophil chemokinetic properties Macrophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines Annual review prize lecture cytokines-killers in the brain? |
| cord-304553-gbwb7fqi | neuraminidase activates latent transforming growth factor beta Predominant contribution of IFN- beta expression to apoptosis induction in human uterine cervical fibroblast cells by influenza- virus infection Local immune responses to influenza virus infection in mice with a targeted disruption of perforin gene T cell- dependent production of IFN- gamma by NK cells in response to influenza A virus Protective cross- reactive cellular immunity to lethal A/ Goose/ Guangdong/1/96-like H5N1 influenza virus is correlated with the proportion of pulmonary CD8(+) T cells expressing gamma interferon Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-304553-gbwb7fqi | synthetic TLR 7 agonists TLR7 is involved in sequence- specific sensing of single- stranded RNAs in human macrophages Toll- like receptor- mediated activation of neutrophils by influenza A virus Immunotherapeutic activity of a conjugate of a Toll- like receptor 7 ligand Administration of a dual toll- like receptor 7 and toll- like receptor 8 agonist protects against influenza in rats Nucleic acid recognition receptors in autoimmunity Control of toll- like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation Treatment of lupus- prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms TLR7 ligands induce higher IFN- alpha production in females Human and avian influenza viruses target different cell types in cultures of human airway epithelium Avian influenza and sialic acid receptors: more than meets the eye? |
| cord-305737-bnzd7b25 | What is the molecular basis of IFIT1 mediated inhibition of virus replication? |
| cord-305737-bnzd7b25 | Why is this the case? |
| cord-304794-z2kx314h | Dr Jekyll or Mr Hyde? |
| cord-304794-z2kx314h | The Bloom's syndrome helicase unwinds G4 DNA Genome- wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability Human papillomavirus G- quadruplexes Spectrum of Epstein- Barr virus- associated diseases Role for G- quadruplex RNA binding by Epstein- Barr virus nuclear antigen 1 in DNA replication and metaphase chromosome attachment G- quadruplexes regulate Epstein- Barr virus- encoded nuclear antigen 1 mRNA translation Targeting G- quadruplexes in gene promoters: a novel anticancer strategy? |
| cord-304794-z2kx314h | The guanine- quadruplex aptamer 93del inhibits HIV-1 replication ex vivo by interfering with viral entry, reverse transcription and integration Cellular uptake of ODNs in HIV-1 human- infected cells: a role for viral particles in DNA delivery? |
| cord-309048-emmtplv3 | So what have plant viruses ever done for virology and molecular biology? |
| cord-311625-d7iycdyh | Antibody- dependent enhancement occurs upon re- infection with the identical serotype virus in feline infectious peritonitis virus infection Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses Intrahost diversity of feline coronavirus: a consensus between the circulating virulent/ avirulent strains and the internal mutation hypotheses? |
| cord-304876-txaoz7oh | Are there clinically relevant nucleoside analogs that are potent against one or multiple respiratory viruses? |
| cord-304876-txaoz7oh | Are there specific amino acid within the active site of(-)ssRNA virus polymerases responsible for the discrimination of 2 0-C- methyl nucleotides? |
| cord-304876-txaoz7oh | Could the exonuclease/ proofreading activity of CoV polymerases excise chain terminators and resume RNA synthesis? |
| cord-304876-txaoz7oh | How were these molecules first identified, and which ones have been approved for commercial use? |
| cord-304876-txaoz7oh | In this case, could the resistance mutations identified in nsp12 alter the chain termination profile of GS-5734, and make it more susceptible to excision? |
| cord-304876-txaoz7oh | What are the current approaches to develop new nucleoside analogs against respiratory RNA viruses? |
| cord-304876-txaoz7oh | What are the molecular determinants of polymerase selectivity against nucleotide analogs? |
| cord-304876-txaoz7oh | Why are n't molecules like ribavirin and its analogs more widely used to treat respiratory viral infections? |
| cord-308331-55ge7kmr | Why do RNA viruses recombine? |
| cord-312332-rwmuucsp | Do cellular RBPs participate in viral particle assembly? |
| cord-307817-2vy28i4m | Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity Structure- activity relationship studies on clinically relevant HIV-1 NNRTIs Non- nucleoside inhibitors of the HCV NS5B polymerase: progress in the discovery and development of novel agents for the treatment of HCV infections Next- generation integrase inhibitors: where to after raltegravir? |
| cord-311982-wkg56xeq | Are all coronavirus positive cats within a household infected with the same viral strain and are some cats co- infected with several FCoV strains simultaneously? |
| cord-311982-wkg56xeq | For example, does the FCoV strain within a defined multi- cat population remain conserved over time or are new strains constantly emerging? |
| cord-311982-wkg56xeq | If new strains do emerge, are they the result of original strain mutation or'de novo'infections from external sources? |
| cord-311982-wkg56xeq | Is the FCoV strain present in the gut always a reflection of the predominant systemic strain, and similarly, do cats with FIP excrete pathogenic FIPV or only FECV? |
| cord-311982-wkg56xeq | Is there a consistent mutation associated with pathogenicity? |
| cord-308884-erofmh39 | Do nucleic acids moonlight as molecular chaperones? |
| cord-308884-erofmh39 | How good is automated protein docking? |
| cord-308884-erofmh39 | The unfolding story of the Escherichia coli Hsp70 DnaK: is DnaK a holdase or an unfoldase? |
| cord-313161-07iwwsfz | The essential question is: which vector system to use? |
| cord-314369-o4nis91y | Should We Put Our Money Where Our Mouth Is? |
| cord-314254-9ye8tfvz | A strategy to estimate unknown viral diversity in mammals Virology: the virus whose family expanded Bats and viruses: friend or foe? |
| cord-314254-9ye8tfvz | Evolving epidemiology of hepatitis C virus Hepatitis C and liver transplantation Novel therapies for hepatitis C- one pill fits all? |
| cord-304498-ty41xob0 | Does the ExoN mutator phenotype result in more rapid adaptation or attenuation associated with lethal mutational load and rapid extinction during infection in vivo? |
| cord-304498-ty41xob0 | Does the mutator phenotype increase susceptibility to mutagens for lethal mutagenesis? |
| cord-304498-ty41xob0 | How do CoVs maintain a large and complex genome over time while allowing sufficient mutation rates for adaptation and trans- species movement? |
| cord-304498-ty41xob0 | In this case the central unanswered research question remains: by what mechanism does nsp14 increase fidelity? |
| cord-304498-ty41xob0 | Is the fidelity of wt CoV replication fixed by highly selected interactions between the RdRp, ExoN and possibly other viral and cellular proteins or is it flexible in response to altered environmental conditions as has been shown for bacteria such as E. coli? |
| cord-304498-ty41xob0 | What are the limitations to CoV genome diversity in vitro and in vivo? |
| cord-304498-ty41xob0 | clues that the last universal common ancestor possessed an RNA genome? |
| cord-304498-ty41xob0 | subgenomic mouse hepatitis virus replicative intermediates function in RNA synthesis Nidovirus transcription: how to make sense …? |
| cord-312240-0k8y86pf | : what is the best therapy for influenza and other viral causes of community- acquired pneumonia? |
| cord-312240-0k8y86pf | Molecular epidemiological analysis of Saffold cardiovirus genotype 3 from upper respiratory infection patients in Taiwan Déjà vu all over again: Koch's postulates and virology in the 21st century Human bocavirus: passenger or pathogen in acute respiratory tract infections? |
| cord-312240-0k8y86pf | What is the role of respiratory viruses in community- acquired pneumonia? |
| cord-313138-y485ev30 | -I by viral RNA Tetratrico peptide repeat interactions: to TPR or not to TPR? |
| cord-313138-y485ev30 | The long view: a bright past, a brighter future? |
| cord-313138-y485ev30 | The tetratricopeptide repeat: a structural motif mediating protein- protein interactions Structure, chromosome localization, and regulation of expression of the interferon- regulated mouse Ifi54/ Ifi56 gene family RING domains: master builders of molecular scaffolds? |
| cord-313439-cadyykks | A review of feline infectious peritonitis virus infection: 1963- 2008 Feline infectious peritonitis: Still an enigma? |
| cord-313439-cadyykks | Differences in cytokine patterns in association with the outcome of infection Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis Detection of subgenomic mrna of feline coronavirus by real- time polymerase chain reaction based on primer- probe energy transfer( p- sg- qpcr) Sequencing of 3c and spike genes in feline infectious peritonitis: Which samples are the most relevant for analysis? |
| cord-303265-v6ci69n0 | An optimal degree of physical and chemical heterogeneity for the origin of life? |
| cord-303265-v6ci69n0 | Did they originate before or after a cellular world was in place? |
| cord-303265-v6ci69n0 | Do viruses exist essentially as selfish parasites, or have they played constructive roles in the biosphere? |
| cord-303265-v6ci69n0 | Does virus variation play a role in the unfolding of viral disease processes? |
| cord-303265-v6ci69n0 | Have viruses been maintained as modulators of the population numbers of their host species? |
| cord-303265-v6ci69n0 | How did replicating and coding RNAs first get together? |
| cord-303265-v6ci69n0 | Is cyanoacetylene prebiotic? |
| cord-303265-v6ci69n0 | Is it quasispecies dynamics that characterize RNA and many DNA viruses, a remnant of an adaptive strategy that presided all life forms in the remote past? |
| cord-303265-v6ci69n0 | Is the behavior of present- day viruses at the population level only an inheritance of their origins or a present- day necessity? |
| cord-303265-v6ci69n0 | Or have they? |
| cord-303265-v6ci69n0 | Origin of hepatitis delta virus Bacteriophages and pathogenicity: more than just providing a toxin? |
| cord-303265-v6ci69n0 | What is the origin of viruses? |
| cord-303265-v6ci69n0 | What selective forces have maintained multiple viruses as parasites of unicellular and multicellular organisms? |
| cord-303265-v6ci69n0 | What selective forces might have led to the integration of these features? |
| cord-303265-v6ci69n0 | Why have a few viral forms not outcompeted most other forms? |
| cord-303265-v6ci69n0 | Why should we feel disappointed by our inability to even foresee the possible answers to these luring questions? |
| cord-314560-rswa5zdn | The role of a mutant CCR5 allele in HIV-1 transmission and disease progression Long- term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti- HIV shRNA, anti- CCR5 ribozyme, and a nucleolar- localizing TAR decoy Antibody mediated in vivo delivery of small interfering RNAs via cell- surface receptors Inhibition of HIV-1 by lentiviral vectortransduced siRNAs in T lymphocytes differentiated in SCID- hu mice and CD34 C progenitor cell- derived macrophages Lentiviral vector delivery of siRNA and shRNA encoding genes into cultured and primary hematopoietic cells Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer Plasmacytoid dendritic cells in immunity Sequence- dependent stimulation of the mammalian innate immune response by synthetic siRNA Noise amidst the silence: offtarget effects of siRNAs? |
| cord-314560-rswa5zdn | cord-314560-rswa5zdn authors: Manjunath, N.; Kumar, Priti; Lee, Sang Kyung; Shankar, Premlata title: Interfering antiviral immunity: application, subversion, hope? |
| cord-315069-xo4mbxei | ( Jones e? al., 1990). |
| cord-306424-gf0bglm0 | IFN- lambda( IFN-??) is expressed in a tissue- dependent fashion and primarily acts on epithelial cells in vivo Severe acute respiratory syndrome- related coronavirus is inhibited by interferon- alpha Interferon- beta and interferongamma synergistically inhibit the replication of severe acute respiratory syndrome- associated coronavirus( SARS- CoV) Evaluation of immunomodulators, interferons and known in vitro SARS- CoV inhibitors for inhibition of SARS- CoV replication in BALB/ c mice Single- dose intranasal administration with mDEF201 |
| cord-306424-gf0bglm0 | IFN- lambda( IFN-??) is expressed in a tissue- dependent fashion and primarily acts on epithelial cells in vivo Severe acute respiratory syndrome- related coronavirus is inhibited by interferon- alpha Interferon- beta and interferongamma synergistically inhibit the replication of severe acute respiratory syndrome- associated coronavirus( SARS- CoV) Evaluation of immunomodulators, interferons and known in vitro SARS- CoV inhibitors for inhibition of SARS- CoV replication in BALB/ c mice Single- dose intranasal administration with mDEF201 |
| cord-306424-gf0bglm0 | Membranous replication factories induced by plus- strand RNA viruses Does form meet function in the coronavirus replicative organelle? |
| cord-306424-gf0bglm0 | interferon induction Cardif is an adaptor protein in the RIG- I antiviral pathway and is targeted by hepatitis C virus Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF VISA is an adapter protein required for virus- triggered IFN-?.?. |
| cord-306424-gf0bglm0 | interferon induction Cardif is an adaptor protein in the RIG- I antiviral pathway and is targeted by hepatitis C virus Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF VISA is an adapter protein required for virus- triggered IFN-?.?. |
| cord-306424-gf0bglm0 | what and how? |
| cord-313684-61hkogdh | Why Children Fare Better than Adults? |
| cord-307598-p54p7enk | Detection of viral RNA-which structure stimulates RIG- I? |
| cord-307598-p54p7enk | RNase cleavage products- ligands for RIG- I and MDA5? |
| cord-307598-p54p7enk | how bad is it? |
| cord-314877-db7tze8j | A long- range RNA- RNA interaction between the 5 and 3 ends of the HCV genome A twist in the tail: SHAPE mapping of long- range interactions and structural rearrangements of RNA elements involved in HCV replication Hepatitis C virus RNA: molecular switches mediated by long- range RNA- RNA interactions? |
| cord-317244-4su5on6s | Bat white- nose syndrome: an emerging fungal pathogen? |
| cord-317244-4su5on6s | Is Marburg Virus Enzootic in Gabon? |
| cord-307914-lgprrwee | ( Gowen et al., 2007)? |
| cord-307914-lgprrwee | , 2009)? |
| cord-307914-lgprrwee | -I given that RIG- I senses the 5 0 diphosphate terminus? |
| cord-307914-lgprrwee | : DNase II deficiency prevents activation of autoreactive B cells by double- stranded DNA endogenous ligands Toll- like receptor 3 in viral pathogenesis: friend or foe? |
| cord-307914-lgprrwee | C a robust activator of MDA5 while many other defined, long dsRNAs such as poly(A: U) are not( Colby and Chamberlin, 1969; Pichlmair et al., 2009)? |
| cord-307914-lgprrwee | The interferon response to intracellular DNA: why so many receptors? |
| cord-304424-048xo7jn | A novel paramyxovirus? |
| cord-304424-048xo7jn | And what exactly did the host look like then? |
| cord-304424-048xo7jn | Are we missing half of the viruses in the ocean? |
| cord-304424-048xo7jn | At what point in host evolution does an RNA viral pathogen arrive? |
| cord-304424-048xo7jn | CRISPR- Cas9 Species- level deconvolution of metagenome assemblies with Hi- C- based contact probability maps Virus discovery: are we scientists or genome collectors? |
| cord-304424-048xo7jn | Metagenomics for the discovery of novel human viruses Global epidemiology of noninfluenza RNA respiratory viruses: data gaps and a growing need for surveillance Viral metagenomics on animals as a tool for the detection of zoonoses prior to human infection? |
| cord-304424-048xo7jn | Other than sampling more broadly and maintaining the exponential growth in Genbank, what are orthogonal challenges for future RNA virus metagenomic studies? |
| cord-304424-048xo7jn | Tombusviridae and Nodaviridae? |
| cord-304424-048xo7jn | What do you get when you cross a picornavirus and a calicivirus? |
| cord-304424-048xo7jn | Where do we begin with RNA virus metagenomics? |
| cord-304424-048xo7jn | Why has RNA virus metagenomics been so successful? |
| cord-313301-7mkadtp9 | Recurrent mutations associated with isolation and passage of SARS coronavirus in cells from non- human primates Mechanisms of avian retrovial host range extension Deletion mutations of the genome segments of wound tumor virus Speciation via habitat selection: the evolution of reproductive isolation as a correlated character Laboratory experiments on speciation: what have we learned in 40 years? |
| cord-316503-wtmmewiz | antisense or anti- protein? |
| cord-312741-0au4nctt | A decade after SARS: strategies for controlling emerging coronaviruses SARS vaccines: where are we? |
| cord-312741-0au4nctt | In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine Inhibition of human coronavirus 229E infection in human epithelial lung cells( L132) by chloroquine: involvement of p38 MAPK and ERK A systematic screen of FDA- approved drugs for inhibitors of biological threat agents Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-312741-0au4nctt | The mercurial nature of neutrophils: still an enigma in ARDS? |
| cord-312741-0au4nctt | the beginning of another SARS- like pandemic? |
| cord-315611-xbj41ekc | What We Know? |
| cord-312688-12san3m7 | The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-309722-04pp3lv0 | : What's new? |
| cord-309722-04pp3lv0 | A review Influence of particle size on regional lung deposition- what evidence is there? |
| cord-309722-04pp3lv0 | An unsuccessful host defence mechanism providing a safety shelter for the bacteria? |
| cord-309722-04pp3lv0 | Delivering on the promise? |
| cord-309722-04pp3lv0 | How can we improve the therapeutic efficacy of RNAi in combating infections to make it clinically relevant? |
| cord-309722-04pp3lv0 | How can we minimize the undesirable effects when cytokines/ chemokines are being targeted? |
| cord-309722-04pp3lv0 | In Molecular Regulation of Endocytosis Nuclear entry of nonviral vectors Pulmonary administration of small interfering RNA: The route to go? |
| cord-309722-04pp3lv0 | RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription Barrier or carrier? |
| cord-309722-04pp3lv0 | When the respiratory functions are compromised in patients with lung disease, is pulmonary delivery a suitable route for administration? |
| cord-317851-lj07947c | What properties make RNA viruses excellent models for experimental evolution? |
| cord-316134-lkd2mj27 | ( Zhou et al., 2018), and vice versa? |
| cord-316134-lkd2mj27 | Are there effects from other viral components? |
| cord-316134-lkd2mj27 | Considering the opposing effects on PEDV replication of N proteins from TGEV, an older virus emerging prior to PEDV, and PDCoV, a newly emerged one, is it possible that nucleocapsid proteins could act as one of the factors in permitting or limiting emergence of enteric swine CoVs? |
| cord-316134-lkd2mj27 | For example, in the context of co- infection, in which all other viral components are present, what would be the net outcomes on replication kinetics of each virus? |
| cord-312001-8p7scli8 | Re- evaluation of the immunological Big Bang Pattern recognition receptors and control of adaptive immunity Approaching the asymptote? |
| cord-312001-8p7scli8 | The interferon response to intracellular DNA: Why so many receptors? |
| cord-314833-6fue84x6 | } Are weak protein- protein interactions the general rule in capsid assembly? |
| cord-314567-purplsjn | How Parkinson's disease meets nucleolar stress NF90 isoforms, a new family of cellular proteins involved in viral replication? |
| cord-314567-purplsjn | The nucleolus- a gateway to viral infection? |
| cord-303533-6s01qplg | Does nidovirus RNA synthesis take place anywhere except inside DMVs? |
| cord-303533-6s01qplg | How do viral and host proteins interact as replicative organelles are formed? |
| cord-303533-6s01qplg | What are the differences in protein composition and conformation in spherules, convoluted membranes, and DMVs? |
| cord-303533-6s01qplg | What happens to the RNA that accumulates inside DMVs? |
| cord-303533-6s01qplg | key: cord-303533- 6s01qplg authors: Neuman, Benjamin W.; Angelini, Megan M.; Buchmeier, Michael J. title: Does form meet function in the coronavirus replicative organelle? |
| cord-312461-5qzpo6l1 | At what stage of illness are rescue oxygenation devices warranted? |
| cord-312461-5qzpo6l1 | For example, what adjunctive therapies are useful? |
| cord-312461-5qzpo6l1 | The pathogenic potential of a microbe Exserohilum rostratum fungal meningitis associated with methylprednisolone injections Microbial threat lists: obstacles in the quest for biosecurity? |
| cord-312461-5qzpo6l1 | What coinfections may be present? |
| cord-315384-eqiokrub | Most infections are caused by viruses, the best known of which are respiratory syncytial virus( RSV) and influenza virus( INF).Why Was This Study Done? |
| cord-315384-eqiokrub | What Did the Researchers Do and Find? |
| cord-315384-eqiokrub | What Do These Findings Mean? |
| cord-315384-eqiokrub | Where Can I Get More Information Online? |
| cord-317037-1qydcc5e | : Are they close relatives? |
| cord-317037-1qydcc5e | A novel mechanism of generating extracellular vesicles during apoptosis via a beads- on- a- string membrane structure Plasma Membrane Lipid Domains as Platforms for Vesicle Biogenesis and Shedding? |
| cord-317037-1qydcc5e | Premises for the Therapeutic Use Mesenchymal stromal cells and their secreted extracellular vesicles as therapeutic tools for COVID-19 pneumonia? |
| cord-317037-1qydcc5e | The chicken or the egg? |
| cord-315054-kji2kfek | are we- pathologists, clinicians, and consumers- ready? |
| cord-318551-c1qr27lg | The nucleolus- a gateway to viral infection? |
| cord-318551-c1qr27lg | What then might be the most appropriate strategy to unambiguously distinguish between factors involved in replication and/or transcription but not in translation, between( À) and( þ) strand RNA synthesis, and between those directly involved in a given mechanism and those that affect this mechanism indirectly? |
| cord-319842-4mnaicki | Do the autophagosome- like membranous structures induced by poliovirus act as scaffolds for RNA replication, or are they part of the host antiviral response? |
| cord-319842-4mnaicki | Why would a virus choose a double- membraned, autopha- gosome- like vesicle on which to replicate its RNA? |
| cord-318749-k91oku7h | How should we think about the ribosome? |
| cord-319501-a2x1hvkk | The action points at which viral proteins function marked with a question mark(?) represent controversial and inconclusive findings in the field or molecular mechanisms not well studied. |
| cord-319501-a2x1hvkk | announcement of the coronavirus study group Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control Inhibition of novel β coronavirus replication by a combination of interferon- α2b and ribavirin Distinct immune response in two MERS- CoV- infected patients: Can we go from bench to bedside? |
| cord-312892-p72zwmtb | ( TLR3) ectodomain Pattern recognition receptors and the innate immune response to viral infection Toll like receptor 3 and viral infections of nervous system Human Toll- like receptor 8 can be cool too: implications for foreign RNA sensing Structural reorganization of the Toll- like receptor 8 dimer induced by agonistic ligands Toll- like receptor 9 processing: the key event in Toll- like receptor 9 activation? |
| cord-321053-lgae22f8 | Novel therapies for hepatitis C-one pill fits all? |
| cord-318751-4v2tl0gi | Secondgeneration inhibitors of the cellular ATPase DDX3 with improved anti- HIV activity: synthesis, structure- activity relationship analysis, cytotoxicity studies, and target validation Viruses and the human DEAD- box helicase DDX3: inhibition or exploitation? |
| cord-314019-8n0jafsk | At what stage during a picornavirus infection does MDA5 become activated? |
| cord-314019-8n0jafsk | Nonetheless, assuming RIG- I is targeted by EMCV, how could this benefit virus replication? |
| cord-314019-8n0jafsk | What RNA(s) are directly bound by MDA5? |
| cord-314019-8n0jafsk | What is the minimum length of MDA5 filaments that can activate MAVS in cells? |
| cord-314019-8n0jafsk | Where and when do viral proteinases encounter and target crucial factors of immune pathways? |
| cord-314019-8n0jafsk | Where does MDA5 gain access to viral RNA PAMPs that are produced in restricted subcellular microenvironments? |
| cord-314019-8n0jafsk | is it only needed for specific( types of) RNA ligands? |
| cord-319635-kh99n7q2 | Why do RNA viruses recombine? |
| cord-319116-2ts6zpdb | Elevated levels of G- quadruplex formation in human stomach and liver cancer tissues G- quadruplex- binding small molecules ameliorate C9orf72 FTD/ ALS pathology in vitro and in vivo G- quadruplex structures and their interaction diversity with ligands Structure, location and interactions of G- quadruplexes Telomere G- quadruplex as a potential target to accelerate telomere shortening by expanding the incomplete end- replication of telomere DNA Telomeric G- quadruplex architecture and interactions with potential drugs Human telomeric G- quadruplex: the current status of telomeric G- quadruplexes as therapeutic targets in human cancer Cell cycle regulation of G- quadruplex DNA structures at telomeres G- quadruplexes in human promoters: a challenge for therapeutic applications G4 DNA in ras genes and its potential in cancer therapy Small molecules targeting c- Myc oncogene: promising anti- cancer therapeutics Making sense of G- quadruplex and i- motif functions in oncogene promoters G- quadruplex structures in the human genome as novel therapeutic targets Targeting G- quadruplexes in gene promoters: a novel anticancer strategy? |
| cord-319116-2ts6zpdb | Targeting unimolecular G- quadruplex nucleic acids: a new paradigm for the drug discovery? |
| cord-319116-2ts6zpdb | radioresistance of D. radiodurans involves G4 DNA- mediated regulation Mapping and characterization of G- quadruplexes in Mycobacterium tuberculosis gene promoter regions G- quadruplexes in pathogens: a common route to virulence control? |
| cord-320921-eumuid3r | Middle East respiratory syndrome coronavirus experimental transmission using a pig model Risk factors for transmission of Middle East respiratory syndrome coronavirus infection during the 2015 outbreak in South Korea Impact of prior seasonal H3N2 influenza vaccination or infection on protection and transmission of emerging variants of influenza A(H3N2)v virus in ferrets Efficacy of seasonal live attenuated influenza vaccine against virus replication and transmission of a pandemic 2009 H1N1 virus in ferrets Predicting"airborne"influenza viruses:( trans-) mission impossible? |
| cord-318164-6rqi17oz | ( 3) Would the use of infected cryopreserved semen affect the fertilization process[ 18, 19]? |
| cord-318164-6rqi17oz | However, apart from safety issues for the sperm bank personnel, this novel pandemic forced us to consider three major issues:( 1) does the SARS- CoV-2 virus reach the testis and the seminal fluid? |
| cord-318164-6rqi17oz | If it does,( 2) are there any long- lasting consequences of viral testicular infection? |
| cord-318164-6rqi17oz | In any case, how might SARS- CoV-2 reach the testis? |
| cord-318164-6rqi17oz | The COVID-19 pandemics: Shall we expect andrological consequences? |
| cord-318164-6rqi17oz | The novel angiotensin- converting enzyme( ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis Evaluating risk, safety and efficacy of novel reproductive techniques and therapies through the EuroGTP II risk assessment tool SARS- CoV-2 pandemic and repercussions for male infertility patients: a proposal for the individualized provision of andrological services COVID-19: should we continue to cryopreserve sperm during the pandemic? |
| cord-320325-sjab8zsk | divalent metal ions either promote or inhibit enzymatic reactions? |
| cord-315616-pvt0amth | 2P P- O- Methylation in the RNA world? |
| cord-315616-pvt0amth | A methyl- RNA genome? |
| cord-315616-pvt0amth | Although ribonucleotide reduction is a crucial link in the transition from RNA to DNA, is this single step suf¢cient? |
| cord-315616-pvt0amth | Can 2P P- O- methylation be carried out by a ribozyme? |
| cord-315616-pvt0amth | How can the model be tested? |
| cord-315616-pvt0amth | If 2P- O- methyl RNA is a candidate intermediate between RNA and DNA, what selection was there to go from methyl- RNA to DNA? |
| cord-315616-pvt0amth | Pyrococcus furiosus: a critical enzyme in the evolution of DNA genomes? |
| cord-315616-pvt0amth | Where is there suf¢cient space to encode simple proteins, then more complex catalytic proteins capable of generating and controlling protein radicals? |
| cord-315616-pvt0amth | title: Methyl- RNA: an evolutionary bridge between RNA and DNA? |
| cord-319194-ukuia48s | Can phylogeneticists and bioinformaticians help virologists to tackle SARS- CoV( severe acute respiratory syndrome coronavirus)? |
| cord-318276-so5jooj0 | Borst, l?( 1986). |
| cord-318276-so5jooj0 | How do eucaryotic ribosomes select initiation regions in messenger RNA? |
| cord-320935-3n157yl4 | : what is its fate in urban water cycle and how can the water research community respond? |
| cord-320935-3n157yl4 | COVID-19: gastrointestinal manifestations and potential fecal- oral transmission Enteric involvement of coronaviruses: is faecal- oral transmission of SARS- CoV-2 possible? |
| cord-320935-3n157yl4 | Put a lid on it: are faecal bio- aerosols a route of transmission for SARS- CoV-2? |
| cord-320351-47d0nby0 | When and how can death be an adaptation? |
| cord-321013-8pkrg0mx | A clinically important virus? |
| cord-321013-8pkrg0mx | If indeed so, could this then indicate a probable basis for the increased pathogenicity of SARS- CoV compared to HCoV- NL63? |
| cord-322084-gkg1059v | In''PCR Protocols''( M. A. Innis, is 31 kb, whereas genomic DI RNA is only 2.6 kb Replication kb from the 3-end of genome, respectively, whereas our and plaque formation of mouse hepatitis virus( MHV-2) in mouse experimental intergenic regions were located only 1.2 kb cell line DBT culture Investi- RNA has multiple intergenic regions, whereas genomic gation of the control of coronavirus subgenomic mRNA transcription by using T7-generated negative- sense RNA transcripts Mechanism of coronavirus transcripbetween the amounts of subgenomic DI RNA and real tion: Duration of primary transcription initiation activity and effect of MHV mRNAs? |
| cord-321607-3r736dnk | The question that ultimately arises, however, is how does the cell distinguish between pathogen- induced cytoskeletal remodeling and that due to physiologic cellular processes? |
| cord-321773-5fw9abzl | Why, how, when? |
| cord-323737-6ajqy0ch | a heat shock- induced methyltransferase Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection? |
| cord-321155-dty18esg | A Problem or a Necessity? |
| cord-321155-dty18esg | Targeting G- quadruplexes in gene promoters: a novel anticancer strategy? |
| cord-321155-dty18esg | rG4-seq reveals widespread formation of G- quadruplex structures in the human transcriptome UTR G- quadruplex structures acting as translational repressors Integrative analysis reveals RNA G- quadruplexes in UTRs are selectively constrained and enriched for functional associations G- quadruplex DNA: a potential target for anti- cancer drug design Quadruplex nucleic acids as targets for anticancer therapeutics G- quadruplexes: selective DNA targeting for cancer therapeutics? |
| cord-319781-6thdg2up | No evidence of SARS- CoV-2 in semen of males recovering from COVID-19 Absence of 2019 novel coronavirus in semen and testes of COVID-19 patients Study of SARS- CoV-2 in semen and urine samples of a volunteer with positive nasopharyngeal swab Clinical characteristics and results of semen tests among men with coronavirus disease 2019 SARS- CoV-2 Presence in seminal fluid: myth or reality COVID-19, or the triumph of monogamy? |
| cord-319781-6thdg2up | The Fundamental Reasons Why laptop Computers should not be used on Your Lap High risk of temporary alteration of semen parameters after recent acute febrile illness Sperm chromatin structure assay is useful for fertility assessment Cytogenetic effects of influenza virus infection on male germ cells of mice Dominant lethality in mice- a test for mutagenicity of influenza X-31 virus 139 Viral epididymitis and orchitis e myth or reality? |
| cord-319781-6thdg2up | The Threat of pandemic influenza: are We Ready? |
| cord-319781-6thdg2up | The X chromosome in immune functions: when a chromosome makes the difference X- chromosome- located microRNAs in immunity: might they explain male/ female differences? |
| cord-319781-6thdg2up | The dual role of the immune response in reproductive organs during Zika virus infection Zika virus causes testicular atrophy Zika virus infection damages the testes in mice Zika virus in semen: a prospective cohort study of symptomatic travellers returning to Belgium Potential effect of Zika virus infection on human male fertility? |
| cord-319781-6thdg2up | what lessons have we learned? |
| cord-323756-atnrw9ew | Approaching the asymptote? |
| cord-318495-1w74wf02 | Can DVGs be harnessed for the control of virus pathogenesis and spread? |
| cord-318495-1w74wf02 | Do DVGs exist for a reason? |
| cord-318495-1w74wf02 | Does the higher order structure of the influenza virus ribonucleoprotein guide sequence rearrangements in influenza viral RNA? |
| cord-318495-1w74wf02 | How do alterations in the DVG population impact virus evolution and adaptation to new hosts? |
| cord-318495-1w74wf02 | How do host factors impact DVG accumulation and activity? |
| cord-318495-1w74wf02 | Random products or encoded in the viral genome? |
| cord-318495-1w74wf02 | Recent work has provided new appreciation for DVG diversity and the potentially critical role of DVGs in defining the clinical outcome of infections; however, a number of questions remain unanswered: what are the molecular mechanisms driving the generation of DVGs? |
| cord-318495-1w74wf02 | Virus- associated small satellite RNAs and viroids display similarities in their replication strategies What has been happening with viroids? |
| cord-318495-1w74wf02 | Why keep waste lying around? |
| cord-318495-1w74wf02 | neurochemical abnormalities in the central nervous system Defective interfering particles: effects in modulating virus growth and persistence Persistence of virulent Semliki Forest virus in mouse brain following co- inoculation with defective interfering particles Defective interfering virus particles modulate virulence Continuous influenza virus production in cell culture shows a periodic accumulation of defective interfering particles Multiple- hit inhibition of infection by defective interfering particles Defective interfering particles of human parainfluenza virus type 3 are associated with persistent infection in cell culture Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad- spectrum antivirals? |
| cord-320713-b37c8aye | How do microRNAs regulate gene expression? |
| cord-320713-b37c8aye | How does influenza virus regulate gene expression at the level of mRNA translation? |
| cord-320713-b37c8aye | What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame? |
| cord-320713-b37c8aye | another mechanism for host protein synthesis shutoff? |
| cord-320713-b37c8aye | is the eIF4E cap- binding factor required for viral mRNA translation? |
| cord-320713-b37c8aye | mRNAs Does phosphorylation of the cap- binding protein eIF4E play a role in translation initiation? |
| cord-324212-aqp73hi9 | recent advances in the development of RNA tools The cellular delivery of antisense oligonucleotides and ribozymes Gene silencing as an adaptive defense against viruses Human viruses under attack by small inhibitory RNA RNA interference Induction and suppression of RNA silencing: insights from viral infections Noise amidst the silence: off- target effects of siRNAs? |
| cord-323973-wszo9s3d | Once- in- a- Century Pandemic? |
| cord-323973-wszo9s3d | One can not help but wonder: why has the development and deployment of practical POC- PCR testing taken so much time? |
| cord-319780-rfj9t99r | A molecular docking study Can angiotensin receptor- blocking drugs perhaps be harmful in the COVID-19 pandemic? |
| cord-319780-rfj9t99r | For example, what are the mechanism/ s underlying why some sufferers of hypertension and/or diabetes might be at higher risk( https://www.immunopaedia.org.za/breakingnews/why-are-hypertension-and-diabetes-patients-at-high-risk-of-severe-covid-19/)? |
| cord-319780-rfj9t99r | How will the evolution of the virus alter rates of infection and the severity of symptoms? |
| cord-319780-rfj9t99r | Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population? |
| cord-319780-rfj9t99r | Is there evidence from the SARS and MERS outbreaks to suggest a commonality of susceptibility? |
| cord-319780-rfj9t99r | Is there evidence that patients on ACE inhibitors or angiotensin receptor blockers were at higher risk with SARS- CoV and MERS- CoV infections and, currently, for SARS- CoV-2 infection? |
| cord-319780-rfj9t99r | N is a receptor for human coronavirus 229E Enteric involvement of coronaviruses: is faecal- oral transmission of SARS- CoV-2 possible? |
| cord-319780-rfj9t99r | Underestimated Opportunistic Pathogens of the Central Nervous System? |
| cord-319780-rfj9t99r | What factor/ s determine resistance to infection? |
| cord-319780-rfj9t99r | What is the impact of contracting the virus on individuals with other underlying conditions? |
| cord-325043-vqjhiv7p | chance or common ancestry? |
| cord-324324-8ybfiz8f | Could have the current COVID-19 outbreak been avoided? |
| cord-324324-8ybfiz8f | What should we expect from the current pandemic? |
| cord-324928-cpryxa6p | A neglected public health concern? |
| cord-324928-cpryxa6p | This raises an intriguing question: did a SINV- like ancestor lose its ability to replicate in vertebrates or did an EILV- like ancestor acquire the ability to replicate in a vertebrate host? |
| cord-324944-ixh3ykrc | Not Applicable;"?": unknown;"NAATs": |
| cord-324697-c0dv1zmi | Despite the further mapping of the SOX targeting element and assessment of secondary structure participation one outstanding question remained: what is the direct impact of these RNA features in target recognition? |
| cord-324697-c0dv1zmi | More specifically, how do these features influence SOX affinity and/or the efficiency by which targets are degraded? |
| cord-325280-4whzcmqv | what's the future holding for us? |
| cord-324984-ojrpsdt9 | , in patients infected with HIV-1 Chemokine control of West Nile virus infection Virological and immunological response to antiretroviral regimens containing maraviroc in HIV type 1-infected patients in clinical practice: role of different tropism testing results and of concomitant treatments Intensification of a raltegravir- based regimen with maraviroc in early HIV-1 infection Maraviroc and reverse transcriptase inhibitors combinations as potential preexposure prophylaxis candidates( S)-methyl-1-piperazinyl]-4-methylpiperidine( Sch-417690/ Sch- D), a potent, highly selective, and orally bioavailable CCR5 antagonist Pharmacokinetics and short- term safety of 873140, a novel CCR5 antagonist, in healthy adult subjects An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-Fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H- imidazo[4, 5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide( PF-232798) Is PF-232798 a possible successor to maraviroc? |
| cord-324984-ojrpsdt9 | molecular chaperone inhibitors: are we there yet? |
| cord-325230-3kg4oe4g | another mechanism for host protein synthesis shutoff? |
| cord-318853-mxyxwkhx | 5 5'UTR geq/ ml at 16 weeks be visible immunologically, but envelope proteins derived from EeRNA sequences corresponding to~10 6- 7 5'UTR geq/ ml at 4- 6 weeks remain unseen? |
| cord-318853-mxyxwkhx | Analysis of cloned DNA gives cleaner data than PCR sequencing but if 100 clones( and multiple HCV quasispecies clones are highly unlikely to be identical) provides definitive sequence, would we process the 101 st to reveal different and, potentially, critical sequence variations? |
| cord-318853-mxyxwkhx | And if we did, how would we recognise its importance? |
| cord-318853-mxyxwkhx | As clear evidence exists for viral disruption of leptin function[ 106] and virus- associated weight gain in humans[ 107] and monkeys[ 108], is it possible the global epidemics of type II diabetes mellitus, insulin resistance, hyperlipidaemia and obesity now prevalent[ 109][ 110][ 111][ 112][ 113][ 114][ 115][ 116], are just that; epidemics fundamentally caused by viruses that co- opt insulin or leptin or other associated receptors for cell access and generate protein quasispecies that disrupt receptor function? |
| cord-318853-mxyxwkhx | But does this certitude reflect reality, at least for viral RNA quasispecies? |
| cord-318853-mxyxwkhx | But why should specific EeRNA sequence frequencies-in other words, HCV RNA pol fidelity-increase after week 8, facilitating adaptive immune responses? |
| cord-318853-mxyxwkhx | Could it also be that ethnically based epidemics of obesity, diabetes mellitus, hypertension and reno- vascular disease( the'metabolic syndrome'), as seen in PIMA Indians, Nauruans and Australian Aborigines[ 115] have developed not primarily because of exposure to"Western"foods and lifestyles-that, after all, are all- pervasive without necessarily having so dramatic an effect on other groups-but because of chronic or recurrent exposure to viruses, or genotypes of viruses to which their particular repertoire of receptor polymorphisms confer no protection? |
| cord-318853-mxyxwkhx | Finally, if immune mechanisms are unable to clear RNA viruses like HCV and do not cause the reduced viral replication seen during acute infection, are they any more likely to be effective against other RNA viruses? |
| cord-318853-mxyxwkhx | I receptor signaling system in JC virus T antigen- induced primitive neuroectodermal tumors-medulloblastomas Hepatitis C virus down- regulates insulin receptor substrates 1 and 2 through up- regulation of suppressor of cytokine signaling 3 Vaccinia virus and the EGF receptor: a portal for infectivity? |
| cord-318853-mxyxwkhx | Is important sequence likely to be present at frequencies of http://www.virologyj.com/content/2/1/70< 1%? |
| cord-318853-mxyxwkhx | Is it possible foetal tolerance is mediated by regulating the fidelity of foetal DNA dependent RNA transcriptases to ensure any cell- surface antigens are expressed heterogeneously and at levels below the threshold of maternal immune responsiveness? |
| cord-318853-mxyxwkhx | Is it possible that self- limiting infections like influenza and SARS also autoregulate their replication, and, like HCV or HBV, become partially dormant, yet remain transcriptionally active, in the face of an active and powerful immune response? |
| cord-318853-mxyxwkhx | The expected consequences disruption of receptor function by variant viral proteins might explain many common biochemical pathologies; For example, what effect would chronic blockade of parathyroid( PTH) receptors by viral proteins have on PTH levels, the parathyroid glands, or bone? |
| cord-318853-mxyxwkhx | This is certainly an accurate synthesis of an extensive and highly complex literature but does it make any sense? |
| cord-318853-mxyxwkhx | What practical meaning does"immune control"have for the individual? |
| cord-318853-mxyxwkhx | Why should HCV replicating at 10 6- 7 geq/ ml at week 6 be invisible to the immune system but visible when replicating at 10 5 geq/ ml long term? |
| cord-325624-6anybxnk | When can axonal injury be beneficial? |
| cord-325966-0g7a9s5z | A narrative review COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? |
| cord-325966-0g7a9s5z | Can we use interleukin-6( IL-6) blockade for coronavirus disease 2019( COVID-19)-induced cytokine release syndrome( CRS)? |
| cord-327855-txryqil7 | involvement of RNase L, protein kinase R, and alternative pathways Activation of NF- κB by double- stranded RNA( dsRNA) in the absence of protein kinase R and RNase L demonstrates the existence of two separate dsRNA triggered antiviral programs Membrane permeability induced by hepatitis A virus proteins 2B and 2BC and proteolytic processing of HAV 2BC Replication of hepatitis A viruses with chimeric 5 nontranslated regions Cleavage of poly( A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff? |
| cord-328259-3g4klpyg | https://www.mg-rast.org/linkin.cgi? |
| cord-322756-ouvn71r9 | : where are we? |
| cord-322756-ouvn71r9 | Dual targeted immunotherapy via in vivo delivery of biohybrid RNAi- peptide nanoparticles to tumourassociated macrophages and cancer cells Barrier or carrier? |
| cord-322756-ouvn71r9 | Here, we have discussed nonviral delivery systems developed for siRNA and mRNA therapeutics in the lung and briefly summarized the What is the exact cellular uptake mechanism of naked RNA in the airways? |
| cord-322756-ouvn71r9 | How can we protect the integrity of RNA molecules against shear and thermal stresses effectively during the aerosolization and drying process? |
| cord-322756-ouvn71r9 | How do we improve the translation of inhaled RNA therapy from animal studies to clinical applications? |
| cord-322756-ouvn71r9 | Is it possible to have a universal pulmonary delivery platform that can be used to deliver different types of RNA therapeutics? |
| cord-322756-ouvn71r9 | What are the delivery barriers to different RNA delivery systems in different respiratory diseases? |
| cord-322756-ouvn71r9 | What are the factors governing its uptake? |
| cord-322756-ouvn71r9 | cell penetrating peptide- based anticancer therapies Cancer targeting peptides Cell- penetrating peptides: design strategies beyond primary structure and amphipathicity Non- viral transfection vectors: are hybrid materials the way forward? |
| cord-328471-oz99upzz | The pharmacology of ornipressin( POR-8): a local vasoconstrictor used in surgery Ornipressin in the treatment of functional renal failure in decompensated liver cirrhosis: effects on renal hemodynamics and atrial natriuretic factor Management of preterm labor: atosiban or nifedipine? |
| cord-328768-2qk884x2 | Does the DNA extraction method matter? |
| cord-325197-j1uo8qmf | , angiotensin I converting enzyme 2 gene( ACE2) in the respiratory system reveal age and gender differences Pulmonary embolism or pulmonary thrombosis in COVID-19? |
| cord-325197-j1uo8qmf | A Review Can COVID 2019 disease induce a specific cardiovascular damage or it exacerbates pre- existing cardiovascular diseases? |
| cord-325197-j1uo8qmf | A crucial role of angiotensin converting enzyme 2( ACE2) in SARS coronavirusinduced lung injury DPP4, the Middle East respiratory syndrome coronavirus receptor, is upregulated in lungs of smokers and chronic obstructive pulmonary disease patients Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus Distinct immune response in two MERS- CoV- infected patients: can we go from bench to bedside? |
| cord-325197-j1uo8qmf | Immunomodulators and antivirals: could they impact on epigenetic pathways underlying cardiovascular dysfunction in COVID-19? |
| cord-325197-j1uo8qmf | Is the recommendation to use high- dose heparin for thromboprophylaxis justified? |
| cord-325197-j1uo8qmf | a randomized clinical trial Epigenetic- sensitive challenges of cardio- hepatic interactions: clinical and therapeutic implications in heart failure patients Clinical features of COVID-19-related liver damage Liver injury during highly pathogenic human coronavirus infections Effects of simvastatin on cell viability and proinflammatory pathways in lung adenocarcinoma cells exposed to hydrogen peroxide Atorvastatin attenuates myocardial remodeling induced by chronic intermittent hypoxia in rats: partly involvement of TLR-4/ MYD88 pathway Metformin- induced suppression of IFN- a via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or noninvasive strategy Coronavirus disease 2019( COVID-19) and cardiovascular disease Precision medicine in distinct heart failure phenotypes: focus on clinical epigenetics New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? |
| cord-327518-yilv9z2m | Cryoelectron tomography of mouse hepatitis virus: insights into the structure of the coronavirion Biochemical aspects of coronavirus replication and virus hostinteraction Nidovirales: evolving the largest RNA virus genome Discovery of first insect nidovirus, a missing evolutionary link in the emergence of the largest RNA virus genomes Nidovirus transcription: how to make sense …? |
| cord-327518-yilv9z2m | In crescent- shaped and spherical( disk- shaped?) |
| cord-327518-yilv9z2m | Similar incidents, though with a less dramatic outcome, seem to have given rise to human coronavirus OC43( a single cross- species transmission of bovine coronavirus from cattle to humans), to human coronavirus 229E( transmitted from bats?) |
| cord-329107-43e2lkht | Friend or foe? |
| cord-329102-2y49kcwu | Transcriptome Global or local? |
| cord-326017-qw4qynqv | ( COVID-19) Lessons for the Future Telemedicine in the Era of COVID-19 Artificial intelligence: Who is responsible for the diagnosis? |
| cord-326017-qw4qynqv | It Is Pneumonia? |
| cord-326017-qw4qynqv | New evidence for an old therapeutic tool? |
| cord-326017-qw4qynqv | in Human Nasopharyngeal Swab Specimens Using Field- Effect Transistor- Based Biosensor Cross- reactive Antibody Response between SARS- CoV-2 and SARS- CoV Infections Clinical Characteristics of Coronavirus Disease 2019 in China Chest radiograph vs. computed tomography scan in the evaluation for pneumonia Middle East respiratory syndrome corona virus: Can radiology be of help? |
| cord-326017-qw4qynqv | the culprit in the autoimmune haemolytic anaemia affecting patients with COVID-19? |
| cord-328252-dk54w8z9 | 3C- Like Protease Regulates Its Interferon Antagonism by Cleaving NEMO Ubiquitin in the activation and attenuation of innate antiviral immunity Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain- like protease? |
| cord-328252-dk54w8z9 | Cell Host Microbe Quo vadis? |
| cord-328252-dk54w8z9 | to Usurp Ubiquitin and SUMO Host Pathways Human coronaviruses: what do they cause? |
| cord-328460-thx9zh11 | : Is a true lab- on- a- chip possible? |
| cord-328460-thx9zh11 | What's next? |
| cord-329504-91te3nu8 | Why were just over half of all reflections that could have been measured at this resolution recorded? |
| cord-329361-0mpbau1b | An siRNA- based microbicide protects miRNA and HIV: promises and mice from lethal herpes simplex virus 2 infection Anti- viral RNA silencing: do we look like plants? |
| cord-329361-0mpbau1b | Progress towards in vivo use of siRNAs gene by systemic administration of modified siRNAs Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing Retrovirus vectors: toward the plentivirus? |
| cord-329710-vqorb6j7 | Why are lopinavir and ritonavir effective against the newly emerged coronavirus 2019? |
| cord-330200-l6bnxi40 | A novel coronavirus from patients with pneumonia in China Emergence of novel coronavirus and COVID-19: whether to stay or die out? |
| cord-331066-ediowz4s | How many N proteins are needed for the complete packaging of the SARS- CoV and SARS- CoV-2 ssRNA genomes? |
| cord-329527-0rlotyz3 | Taxonomy of the order Mononegavirales: update 2016 H1N1 encephalitis with malignant edema and review of neurologic complications from influenza Neurological complications of middle east respiratory syndrome coronavirus: a report of two cases and review of the literature Human metapneumovirus persists in BALB/ c mice despite the presence of neutralizing antibodies Taxonomy of the order Mononegavirales: update 2018 Bronchiolitis- associated encephalopathy in critically- ill infants: an underestimated complication? |
| cord-329527-0rlotyz3 | what have we learnt from the ordeal? |
| cord-331414-i0oxm5mr | Why do RNA viruses recombine? |
| cord-330131-yfhrmbvx | The SARS case study: an alarm clock? |
| cord-330131-yfhrmbvx | Then, what about their degradation and salvage? |
| cord-332270-fusfdkjw | : Are we any closer to a cure? |
| cord-330800-s91zfzfi | Molecular diagnosis of infectious diseases using cytological specimens Point- counterpoint: is the era of viral culture over in the clinical microbiology laboratory? |
| cord-330800-s91zfzfi | Where do we go from here? |
| cord-332003-67e9fchy | Heparan sulfate proteoglycan as a cell- surface endocytosis receptor Glycosaminoglycans in the cellular uptake of drug delivery vectors-bystanders or active players? |
| cord-332006-if46jycd | Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy Efficient delivery of small interfering RNA to bone- metastatic tumors by using atelocollagen in vivo Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits siRNA and the lung: research tool or therapeutic drug? |
| cord-334082-fyxn0g3v | Expression of animal virus genomes Here a virus, there a virus, everywhere the same virus? |
| cord-332747-u46xryoo | Case Closed? |
| cord-332844-2se4d1yp | Fauquet Japanese encephalitis virus: molecular biology and vaccine development Control of Japanese encephalitis- within our grasp? |
| cord-334771-uy3s6443 | Epidemiology of Japanese encephalitis in India: national conference on Japanese encephalitis Jamshedpur fever Etiology of the 1965 epidemic of febrile illness in Nagpur city, Maharashtra state Isolation of Chandipura virus from the blood in acute encephalopathy syndrome Outbreak of killer brain disease in children: mystery or missed diagnosis? |
| cord-324137-nau83mjv | , are the plasmids of other bacteria also devoid of G4s? |
| cord-324137-nau83mjv | Are the differences in the density and distribution of G4s in pathogens influenced by the ecological relationship they share with the host? |
| cord-324137-nau83mjv | Are the prokaryotic ORFs devoid of G4s to cut down on the energy cost of resolution of G4 for translation? |
| cord-324137-nau83mjv | As in D. radiodurans, are the unique adaptations of other extremophiles regulated by G4s? |
| cord-324137-nau83mjv | Do G4s represent structural elements for conservation of energy in bacterial metabolism? |
| cord-324137-nau83mjv | Do the pathogenicity islands in bacterial genomes have unique G4 profiles? |
| cord-324137-nau83mjv | Does the presence of G4s as an additional level of coordinated gene control in operons also signify the same? |
| cord-324137-nau83mjv | In other words, are there differences in the genomic densities of G4s among parasites, symbionts, commensals, and mutualists? |
| cord-324137-nau83mjv | Is G4-mediated control of gene expression exercised only in the early stages of central dogma to conserve energy? |
| cord-324137-nau83mjv | Microbiol G- quadruplexes in pathogens: a common route to virulence control? |
| cord-324137-nau83mjv | Stability and kinetics of G- quadruplex structures High- throughput sequencing of DNA G- quadruplex structures in the human genome How long is too long? |
| cord-324137-nau83mjv | Supplemental information associated with this article can be found Do G4-unwinding helicases encoded by the host interact with G4s in pathogens during infection? |
| cord-324137-nau83mjv | and the ability of G4s to pause replication, are they selectively eliminated from extrachromosomal elements to minimize interference, if any, in vertical transmission? |
| cord-324137-nau83mjv | mRNA translation Is the Epstein- Barr virus EBNA-1 protein an oncogen? |
| cord-324137-nau83mjv | such host- microbe interactions doubleedged swords that help the host to defend some infections and prove to be detrimental in others? |
| cord-335614-qh98622y | The role of antioxidants and antioxidant- related enzymes in protective responses to environmentally induced oxidative stress Peroxisomes take shape Caspase-11-dependent pyroptosis of lung epithelial cells protects from melioidosis while caspase-1 mediates macrophage pyroptosis and production of IL-18 Signaling by ROS drives inflammasome activation Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector? |
| cord-333547-88dkh6xd | State of the knowledge and research needs Computational analysis of SARS- CoV-2/ COVID-19 surveillance by wastewater- based epidemiology locally and globally: Feasibility, economy, opportunities and challenges Characteristics of pediatric SARS- CoV-2 infection and potential evidence for persistent fecal viral shedding Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Prolonged presence of SARS- CoV-2 viral RNA in faecal samples Evidence for Gastrointestinal Infection of SARS- CoV-2 COVID-19: faecal- oral transmission? |
| cord-333547-88dkh6xd | What Protocols for Biosafety, Molecular Detection and Serological Diagnostics? |
| cord-333547-88dkh6xd | What do we know? |
| cord-332632-u2ud0vmq | : what resistance and tolerance can teach us about treating infectious diseases Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice Immune responses against classical swine fever virus: between ignorance and lunacy, Front Innate immunity: quo vadis? |
| cord-332632-u2ud0vmq | TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus Nucleic acids and endosomal pattern recognition: how to tell friend from foe? |
| cord-332632-u2ud0vmq | What can pestiviral endonucleases teach us about innate immunotolerance? |
| cord-332632-u2ud0vmq | von der Biologie zur Bekämpfung Pestivirus control programs: how far have we come and where are we going? |
| cord-336093-ic6q6ke8 | Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene Flaviviral methyltransferase/ RNA interaction: structural basis for enzyme inhibition Discovery of an RNA virus 3 0? |
| cord-334463-nvu5tqxb | The poliovirus receptor: a hook, or an unzipper? |
| cord-335864-392xmrq0 | How are circRNAs translated by non- canonical initiation mechanisms? |
| cord-335864-392xmrq0 | The trimethylguanosine cap structure of U1 snRNA is a component of a bipartite nuclear targeting signal Non- coding RNA: what is functional and what is junk? |
| cord-333261-knj2rrut | How does this correlate to sleep habits and stress levels? |
| cord-333261-knj2rrut | This information can help in answering questions such as: What types of mutation occur? |
| cord-333261-knj2rrut | What percentage of the respiratory infections is HRV? |
| cord-333261-knj2rrut | What types of HRV are prevalent? |
| cord-333261-knj2rrut | Who contracts HRV? |
| cord-332992-8rmqg4rf | : what do we know so far? |
| cord-332992-8rmqg4rf | Front Public Health Trained immunity: a tool for reducing susceptibility to and the severity of SARS- CoV-2 infection Complement as a target in COVID-19? |
| cord-332992-8rmqg4rf | Indeed, demographic differences as well as differences in health status, health care, COVID-19 treatment and cause of death assessment( i.e. did a person die with or die from COVID-19?), may explain the differences in reported case- fatality rates between different countries. |
| cord-332992-8rmqg4rf | SARS- CoV-2 Are pangolins the intermediate host of the 2019 novel coronavirus( SARS- CoV-2)? |
| cord-332992-8rmqg4rf | The possible mechanisms of action of 4-aminoquinolines( chloroquine/ hydroxychloroquine) against SARS- CoV-2 infection( COVID-19): a role for iron homeostasis? |
| cord-336560-m5u6ryy9 | Interferon- Stimulated Genes: What Do They All Do? |
| cord-336560-m5u6ryy9 | New treatment options for delta virus: Is a cure in sight? |
| cord-337339-0vkigjv2 | Infection and Rapid Transmission of SARS- CoV-2 in Ferrets Is there an ideal animal model for SARS? |
| cord-335067-tg66h99q | Risk factors for human disease emergence How many human RNA viruses are there? |
| cord-335067-tg66h99q | which kinds of viruses should we be most worried about?' |
| cord-337026-osgi06o4 | Can the coronavirus disease 2019( COVID-19) affect the eyes? |
| cord-336447-hpnkou41 | A systematic review of asymptomatic infections with COVID-19 Evaluation of COVID-19 RT- q PCR test in multi- sample pools Preliminary prediction of the basic reproduction number of the Wuhan novel coronavirus 2019-nCoV Diagnosis of the coronavirus disease( COVID-19): rRT- PCR or CT? |
| cord-332710-2s14knw6 | How are the acceptor RNA sites selected? |
| cord-332710-2s14knw6 | RNA synthesis? |
| cord-332710-2s14knw6 | Several issues regarding coronavirus recombination remain unresolved, particularly concerning the mechanism of recombination, e.g. what is the sequence requirement for recombination? |
| cord-332710-2s14knw6 | What are the protein factors involved in recombination? |
| cord-337673-1nau263l | nature abhors a double- strand Role for a bidentate ribonuclease in the initiation step of RNA interference RNA interference is mediated by 21-and 22-nucleotide RNAs Argonaute2, a link between genetic and biochemical analyses of RNAi Single- stranded antisense siRNAs guide target RNA cleavage in RNAi Transgenes and gene suppression: telling us something new? |
| cord-334891-4jgtxg07 | Targeting human TLRs to combat COVID-19: A solution? |
| cord-337361-salby0fu | How do viruses interact with stress- associated RNA granules? |
| cord-337361-salby0fu | Why do RNA viruses recombine? |
| cord-334315-ymkrgj0h | Can viruses also influence host transcription by manipulating RNA decay pathways to short- circuit feedback regulatory mechanisms? |
| cord-334315-ymkrgj0h | Could sfRNAmediated inactivation of Xrn1 cause a defect in the coordination of RNA decay and transcription in the host? |
| cord-334315-ymkrgj0h | How do virusinduced changes in RNA decay pathways interface with potential changes in innate immune responses? |
| cord-334315-ymkrgj0h | How might changes in host mRNA stability contribute to virus- induced pathology during infection( Figure 1)? |
| cord-334315-ymkrgj0h | What are the consequences of viral inactivation of decay factors like Xrn1 in terms of disease? |
| cord-338901-1kzy7rts | a retrospective cohort study Use of chloroquine in viral diseases Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-336775-d4hi9myk | Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-336775-d4hi9myk | Insights into the structure of the coronavirion Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein Modulation of murine dendritic cell function by adenine nucleotides and adenosine: involvement of the A(2B) receptor Environmental Contamination and Viral Shedding in MERS Patients During MERS- CoV Outbreak in South Korea Emergence of Novel Coronavirus and COVID-19: whether to stay or die out? |
| cord-336775-d4hi9myk | Really'Special'as Viral Reservoirs? |
| cord-336775-d4hi9myk | what can they teach us about the severe acute respiratory syndrome? |
| cord-335231-617e5dcy | An unusual hantavirus outbreak in southern Argentina: person- toperson transmission? |
| cord-335231-617e5dcy | Could hantaviruses in human saliva be infectious and initiate infection? |
| cord-338307-vfutmwxq | Clinical and virologic observation of a persistent viral infection Are snRNPs involved in splicing? |
| cord-338307-vfutmwxq | The use of a genetically incompatable combination of host and virus( MHV) for the study of mechanisms of host resistance Is genetic resistance to mouse hepatitis based on immunological reactions? |
| cord-339976-tg2jkss7 | The big question now: will it be back? |
| cord-338812-q24jycgk | What's new in the nucleolus? |
| cord-336554-n8n5ii5k | An analysis based on decade- long structural studies of SARS Do viral infections mimic bacterial sepsis? |
| cord-336554-n8n5ii5k | COVID-19 treatment by repurposing drugs until the vaccine is in sight Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: role of epigenetic histone modifications ACE 2: more of Ang 1- 7 or less Ang II? |
| cord-336554-n8n5ii5k | COVID-19? |
| cord-336554-n8n5ii5k | Dexamethasone for COVID-19? |
| cord-336554-n8n5ii5k | Ribavirin, remdesivir, sofosbuvir, galidesivir, and tenofovir against SARS- CoV-2 RNA dependent RNA polymerase( RdRp): a molecular docking study Computational target- based drug repurposing of elbasvir, an antiviral drug predicted to bind multiple SARS- CoV-2 proteins COVID-19 and chronological aging: senolytics and other anti- aging drugs for the treatment or prevention of corona virus infection? |
| cord-336554-n8n5ii5k | an open- label, randomised, phase 2 trial Mechanisms of coronavirus cell entry mediated by the viral spike protein SARS- CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? |
| cord-339172-210dwhgj | if RNA synthesis would indeed occur inside closed DMVs or VPs, how then are import and export across the double membrane achieved? |
| cord-340325-0oh40b6r | From NIS to mNIS+ 7 Translate Bio Announces FDA Clearance to Proceed with a Single- ascending Dose( SAD) Phase 1/2 Clinical Trial for Ornithine Transcarbamylase( OTC) Deficiency, GlobeNewswire News Room Long- term efficacy and safety of mRNA therapy in two murine models of methylmalonic acidemia Current issues of RNAi therapeutics delivery and development Mechanism of nanoparticle- induced hypersensitivity in pigs: complement or not complement? |
| cord-341050-hnuogpqn | Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides Carbohydrate- binding agents: a potential future cornerstone for the chemotherapy of enveloped viruses? |
| cord-336628-0evl3wnd | Can we use interleukin-6( IL-6) blockade for coronavirus disease 2019( COVID-19)-induced cytokine release syndrome( CRS)? |
| cord-336628-0evl3wnd | Inhibitors in the Treatment of Serious COVID-19: A Promising Therapy Dexamethasone for COVID-19? |
| cord-336628-0evl3wnd | Signaling NF- kappaB and virus infection: who controls whom Who's Driving? |
| cord-341171-s8vkgdhf | Why Are Thymines More Reactive? |
| cord-338358-ppjxo2di | Arginine increases development of in vitro- produced porcine embryos and affects the protein arginine methyltransferase? |
| cord-338358-ppjxo2di | Dimethylarginine dimethylaminohydrolase? |
| cord-338358-ppjxo2di | Guide pair mixes 1? |
| cord-338358-ppjxo2di | The overall blastocyst rates for CRISPR guide pairs 1? 5, 2? 4, 3? |
| cord-341071-nwrl1qws | Are Aptamers the Wished Antiviral Drugs? |
| cord-340475-h0q1m3ed | This raises the question why the infection persist in spite of increased levels of antiviral factors? |
| cord-341034-2oigu75k | AMPKmediated inhibition of mTOR kinase is circumvented during immediate- early times of human cytomegalovirus infection Treatment of insulin resistance with metformin in naive genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirin Pioglitazone as adjuvant therapy in chronic hepatitis C: sequential rather than concomitant administration with pegylated interferon and ribavirin? |
| cord-341034-2oigu75k | Semliki Forest virus RNA requires continuous lipid synthesis Role of Cellular Lipids in Positive- Sense RNA Virus Replication Complex Assembly and Function Molecular biology of rift valley Fever virus Intracellular distribution of rubella virus nonstructural protein P150 Characterization of rubella virus replication complexes using antibodies to double- stranded RNA Ultrastructure of Kunjin virus- infected cells: colocalization of NS1 and NS3 with double- stranded RNA, and of NS2B with NS3, in virus- induced membrane structures Replication and gene function in Kunjin virus Kunjin RNA replication and applications of Kunjin replicons Molecular and ultrastructural analysis of heavy membrane fractions associated with the replication of Kunjin virus RNA Wrapping things up about virus RNA replication Kunjin virus: an Australian variant of West Nile? |
| cord-341176-83khavoh | An updated evolutionary classification of CRISPR- Cas systems Diversity and evolution of class 2 CRISPR- Cas systems Cas13b is a type VI- B CRISPR- associated RNA- guided RNase differentially regulated by accessory proteins Csx27 and Csx28 Structural basis for the RNAguided ribonuclease activity of CRISPR- Cas13d Discovery and Functional Characterization of Diverse Class 2 CRISPR- Cas Systems New variants of CRISPR RNA- guided genome editing enzymes CRISPR- Cas13 Precision Transcriptome Engineering in Cancer RNA Interference in the Age of CRISPR: Will CRISPR Interfere with RNAi? |
| cord-340423-f8ab7413 | How does the genome structure and lifestyle of a virus affect its population variation? |
| cord-340423-f8ab7413 | Nonreplicative homologous RNA recombination: promiscuous joining of RNA pieces? |
| cord-340423-f8ab7413 | The question that arises is: How do RNA viruses withstand mutation? |
| cord-340423-f8ab7413 | Why do RNA viruses recombine? |
| cord-342344-jjnf4yje | Does COVID-19 transmit via expiratory particles? |
| cord-339456-82iks0xf | According to these technical specifications, cultivable nonenveloped positive- sense single- stranded RNA(? ssRNA) virus shall be used as such a control( ISO/ TS 1526- 1 2013; ISO/ TS 1526- 2 2013). |
| cord-339456-82iks0xf | Each MS2 phage- like assembly has 180 units of coat protein and each coat protein has a His 6 tag exposed outward from the phage- like assembly, allowing access of the chelated Co 2? |
| cord-339456-82iks0xf | It is a? ssRNA virus. |
| cord-339456-82iks0xf | Numbers of bases are relative to the start of the MS2 replicase initiation codon AUG where A is? |
| cord-339456-82iks0xf | Schematic illustration of the purification of His- tagged MS2 phage- like particles with a Co 2? |
| cord-339456-82iks0xf | The MS2 phage particle consists of 90 copies of coat protein dimers, one copy of the maturase protein( A- protein) and one molecule of viral? ssRNA. |
| cord-339456-82iks0xf | The lysis gene overlaps the coat and replicase genes and is translated in the? 1 reading frame coat protein and the stem- loop- lacZ hybrid RNA were coexpressed in E. coli and the encapsidation of the stem- loop- lacZ RNA into phage- like particles was investigated. |
| cord-339456-82iks0xf | used this system to produce His- tagged phage- like particles which can be easily purified using affinity chromatography on Co 2? |
| cord-342676-ykog278j | vitro RNA chaperoning and intrinsic disorder in the core proteins of Flaviviridae Interaction of hepatitis C virus core protein with viral sense RNA and suppression of its translation Selective binding of hepatitis C virus core protein to synthetic oligonucleotides corresponding to the 5′ untranslated region of the viral genome Specific in vitro association between the hepatitis C viral genome and core protein Detection of Cellular Proteins and Viral Core Protein Interacting with the 5′ Untranslated Region of Hepatitis C Virus RNA Role of RNA structures in genome terminal sequences of the hepatitis C virus for replication and assembly Down- regulation of the internal ribosome entry site( IRES)-mediated translation of the hepatitis C virus: critical role of binding of the stem- loop IIId domain of IRES and the viral core protein Hepatitis C virus RNA: molecular switches mediated by long- range RNA- RNA interactions? |
| cord-341330-31ngknq4 | , What do all the Prime MM- GBSA energy properties mean? |
| cord-341330-31ngknq4 | What do all the Prime MM- GBSA energy properties mean? |
| cord-341330-31ngknq4 | What is wrong? |
| cord-341330-31ngknq4 | What is wrong? |
| cord-343963-99rd3o79 | Hepatitis C Virus induces the mitochondrial translocation of Parkin and subsequent mitophagy Autophagy and RNA virus interactomes reveal IRGM as a common target MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation How do microRNAs regulate gene expression? |
| cord-343963-99rd3o79 | NS5A nonstructural protein: a new paradigm for phosphorylation- dependent viral RNA replication? |
| cord-342901-ca2xxkb2 | So what are we to make of all the proposed ITAFs for PV and other closely related enteroviruses? |
| cord-342901-ca2xxkb2 | virus( HAV) proteinase 3C inhibits HAV IRES- dependent translation and cleaves the polypyrimidine tract- binding protein Polypyrimidine tract binding protein functions as a negative regulator of feline calicivirus translation Stress granules and cell signaling: more than just a passing phase? |
| cord-341804-rnj3wtg4 | A Systematic 11 Tocilizumab for cytokine storm syndrome in COVID-19 pneumonia: an 15 increased risk for candidemia? |
| cord-341804-rnj3wtg4 | A potential antiviral drug for the treatment of SARS- CoV-2 by blocking the 22 trimerization of viral spike glycoprotein? |
| cord-341804-rnj3wtg4 | The 2 Return of the Coronavirus: 2019-nCoV ADMET in silico modelling: towards prediction paradise? |
| cord-341804-rnj3wtg4 | Why tocilizumab could be an effective treatment for severe COVID-19? |
| cord-342412-azkamnpa | Diagnostic Medical Parasitology Diagnostic Medical Parasitology Acute otitis media in the era of effective pneumococcal conjugate vaccine: will new pathogens emerge? |
| cord-342412-azkamnpa | Emerg Infect Dis Long- term studies of hantavirus reservoir populations in the southwestern United States: Rationale, potential, and methods West Nile Virus: a growing concern? |
| cord-342412-azkamnpa | First outbreak of vancomycin- resistant enterococci in a tertiary hospital in Turkey Epidemic and nonepidemic multidrug- resistant Enterococcus faecium Evaluation of performance and potential clinical impact of ProSpecT Shiga toxin Escherichia coli microplate assay for detection of Shiga Toxin- producing E. coli in stool samples Invasive serotype a Haemophilus influenzae infections with a virulence genotype resembling Haemophilus influenzae type b: emerging pathogen in the vaccine era? |
| cord-342412-azkamnpa | a 6-year follow- up Emerging rickettsioses of the Thai- Myanmar border Is murine typhus re- emerging in Portugal? |
| cord-344006-0iq9s94n | In patients of COVID-19, what are the symptoms and clinical features of mild and moderate cases? |
| cord-344006-0iq9s94n | what next? |
| cord-344410-yo9libo0 | : how to make sense? |
| cord-344410-yo9libo0 | What then, is the phylogenetic relationship of these different motifs among RNA viruses? |
| cord-344749-omzhhr0k | The pathogenesis of infection with minute virus of mice depends on expression of the small nonstructural protein NS2 and on the genotype of the allotropic determinants VP1 and VP2 Viruses Immunity to Avian leukosis virus: where are we now and what should we do? |
| cord-344782-ond1ziu5 | Molecular comparison of isolates of an emerging fish pathogen, Koi herpesvirus, and the effect of water temperature on mortality of experimentally infected Koi Is horizontal transmission of the ostreid herpesvirus OsHV-1 in Crassostrea gigas affected by unselected or selected survival status in adults to juveniles? |
| cord-344714-0cam9ipf | Anti- inflammatory effects of flavonoids in neurodegenerative disorders Phytochemicals in cancer prevention and therapy: truth or dare? |
| cord-344714-0cam9ipf | Coagulation and inflammation cross- talking Dexamethasone in the management of covid-19 Antioxidant polyphenols in cancer treatment: Friend, foe or foil? |
| cord-344714-0cam9ipf | The effect of quercetin on different viruses Activity of some flavonoids against viruses Antiviral effect of flavonoids on human viruses Vanden Berghe, Can ethnopharmacology contribute to the development of antiviral drugs? |
| cord-344714-0cam9ipf | food health dis COVID-19 and chronological aging: senolytics and other anti- aging drugs for the treatment or prevention of corona virus infection? |
| cord-345647-h3imwhss | How Far Have we Come and Where Are we Going? |
| cord-343350-04e6wvov | ( Boone) post- larvae Fenneropenaeus indicus is protected from white spot disease by oral administration of inactivated white spot syndrome virus Doublestranded RNA induces sequence- specific antiviral silencing in addition to nonspecific immunity in a marine shrimp: convergence of RNA interference and innate immunity in the invertebrate antiviral response? |
| cord-343350-04e6wvov | An RNA- directed nuclease mediates post- transcriptional gene silencing in Drosophila cells Argonaute2, a link between genetic and biochemical analyses of RNAi Single- stranded antisense siRNAs guide target RNA cleavage in RNAi RNA silencing: no mercy for viruses? |
| cord-343350-04e6wvov | Is RNA interference involved in intrinsic antiviral immunity in mammals? |
| cord-343350-04e6wvov | Viral subversion of the immune system Regulation of apoptosis by viral gene products Does hyperthermia increase apoptosis in white spot syndrome virus( WSSV)-infected Litopenaeus vannamei? |
| cord-344321-fjer281d | Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet- derived growth factor B by selective aptamer AX102 PDGFR? |
| cord-345863-j01l71dh | It is, however, likely that host immune responses play a significant, but not sufficiently elucidated, role in the pathogenesis, and the question remains: What are the responses by the macrophages when infected with FCoV? |
| cord-340189-jo38hjqa | Are people usually diagnosed before or after they are contagious? |
| cord-340189-jo38hjqa | How can we relate these two values? |
| cord-340189-jo38hjqa | How is it that 10 genes code for> 20 proteins? |
| cord-340189-jo38hjqa | How long does it take a single infected person to yield one million infected people? |
| cord-340189-jo38hjqa | How much is known about the SARS- CoV-2 genome and proteome? |
| cord-340189-jo38hjqa | How similar is SARS- CoV-2 to the common cold and flu viruses? |
| cord-340189-jo38hjqa | How so? |
| cord-340189-jo38hjqa | If everybody continued to behave as usual, how long would it take the pandemic to spread from one person to a million infected victims? |
| cord-340189-jo38hjqa | What are the meanings of R 0,'latent period'and'infectious period'? |
| cord-340189-jo38hjqa | What is the difference between the case fatality rate and the infection fatality rate? |
| cord-340189-jo38hjqa | Why have detailed distributions of these parameters across people not been published? |
| cord-340189-jo38hjqa | Why was the initial quarantine period two weeks? |
| cord-345157-fhmhpobi | Who regulates whom? |
| cord-341029-49360l2a | : Inferences on protein evolution Are viruses a source of new protein folds for organisms? |
| cord-341029-49360l2a | Applying both comparative genomic and phylogenomic strategies, we asked a number of crucial questions: Can we quantify viral diversity? |
| cord-341029-49360l2a | Are viruses infecting different organisms evolutionarily related? |
| cord-341029-49360l2a | Are viruses monophyletic or polyphyletic? |
| cord-341029-49360l2a | Can we identify protein folds that define viral lineages based on common virion architectures? |
| cord-341029-49360l2a | Here, the more relevant question was asked: Do viruses infecting distantly related hosts share common protein folds? |
| cord-341029-49360l2a | How many unique protein folds exist in the virosphere? |
| cord-341029-49360l2a | The origins and ongoing evolution of viruses Viral proteins functioning in organelles: A cryptic origin? |
| cord-341029-49360l2a | What is the predominant direction of gene transfer( cell- to- virus or virus- to- cell)? |
| cord-341029-49360l2a | What were the earliest replicons? |
| cord-341029-49360l2a | Where do viruses lie on the tree of life? |
| cord-343662-scn7b4c6 | The four dimensions of noncoding RNA conservation Probing Xist RNA structure in cells using targeted structure- Seq Computing and visualizing dynamic time warping alignments in R: the dtw package Regulation of microRNA biogenesis Analysis of energy- based algorithms for RNA secondary structure prediction BLAT- The BLAST- Like Alignment Tool Scaling up dynamic time warping for datamining applications Genome- wide measurement of RNA secondary structure in yeast Global or local? |
| cord-345898-a6vt8kso | Flavivirus induces interferon- beta gene expression through a pathway involving RIG- I- dependent IRF-3 and PI3K- dependent NF- kappaB activation A dark- to- bright reporter cell for classical swine fever virus infection Tricistronic hepatitis C virus subgenomic replicon expressing double transgenes Structural analysis of foot- and- mouth disease virus 3C protease: a viable target for antiviral drugs? |
| cord-346314-o9fjpqaj | HIV-1 Tat fluctuations drive phenotypic diversity DEDD and DEDD2 associate with caspase-8/10 and signal cell death Chaperones and multitasking proteins in the nucleolus: networking together for survival? |
| cord-346267-l08ld2cy | And second, by using evolutionary models that account for selection, can we infer more realistic estimates of the ages of these viruses? |
| cord-346267-l08ld2cy | First, can purifying selection mask the ancient history of RNA viruses? |
| cord-346267-l08ld2cy | HIV-2 Relaxed selection and the evolution of RNA virus mucin- like pathogenicity factors Immune and artificial selection in the haemagglutinin( H) glycoprotein of measles virus Increased positive selection pressure in persistent( SSPE) versus acute measles virus infections Can deleterious mutations explain the time dependency of molecular rate estimates? |
| cord-347992-coby2m6e | In vitro selection procedures for identifying DNA and RNA aptamers targeted to nucleic acids and proteins Berzal- Herranz, A. RNA selection and evolution in vitro: powerful techniques for the analysis and identification of new molecular tools Aptamers: a new class of oligonucleotides in the drug discovery pipeline? |
| cord-342634-4ouhdjsr | But how is the opening of tertiary structure elements accomplished without the hydrolysis of ATP? |
| cord-342634-4ouhdjsr | How common are extraribosomal functions of ribosomal proteins? |
| cord-342634-4ouhdjsr | The prion protein has RNA binding and chaperoning properties characteristic of nucleocapsid protein NCP7 of HIV-1 Scavenger, transducer, RNA chaperone? |
| cord-342634-4ouhdjsr | What Are RNA Chaperones and Proteins with RNA Chaperone Activity? |
| cord-346978-ubkqny8j | : What can saliva tell us? |
| cord-346978-ubkqny8j | Do Not Rule Out COVID Saliva is a non- negligible factor in the spread of COVID-19 Clinical Significance of a High SARS- CoV-2 Viral Load in the Saliva Could SARS- CoV-2 be transmitted via speech droplets? |
| cord-346978-ubkqny8j | Saliva- Friend and Foe in the COVID-19 Outbreak Rapid detection of SARS- CoV-2 in saliva: can an endodontist take the lead in point- of- care COVID-19 testing? |
| cord-347302-ylnb6qfl | The question remains: what is the function of cholesterol in enterovirus replication? |
| cord-347302-ylnb6qfl | This raises the question: where does RO cholesterol come from? |
| cord-347302-ylnb6qfl | What is the purpose of PI4P in enterovirus replication? |
| cord-347221-g98q9cga | Front Immunol Immune response in severe infection: could life- saving drugs be potentially harmful? |
| cord-347221-g98q9cga | Hype or Hope? 2020: |
| cord-347221-g98q9cga | J o u r n a l P r e-p r o o f Epidemiologic clues to SARS origin in China Surveillance of influenza pandemic( H1N1) 2009 in Spain Middle East respiratory syndrome coronavirus: epidemic potential or a storm in a teacup? |
| cord-345654-vyz6f3he | Can we rule out that a dedicated research effort with sufficient funds and expertise could produce a highly virulent and transmissible synthetic virus? |
| cord-345654-vyz6f3he | Culicoides and the emergence of bluetongue virus in northern Europe Incriminating bluetongue virus vectors with climate envelope models Why did bluetongue spread the way it did? |
| cord-345654-vyz6f3he | The evolution of host specialization: are trade- offs overrated? |
| cord-345654-vyz6f3he | The experimental evolution of specialists, generalists, and the maintenance of diversity Arbovirus evolution in vivo is constrained by host alternation Trade- offs in host range evolution of plant viruses Emerging viruses: why they are not jacks of all trades? |
| cord-345654-vyz6f3he | Why do RNA viruses recombine? |
| cord-345654-vyz6f3he | Why do bacteria engage in homologous recombination? |
| cord-349011-kxhpdvri | Where in the Cell Are You? |
| cord-346138-ip42zcld | Are they related to the symptoms? |
| cord-346138-ip42zcld | How do these values change during the course of the disease? |
| cord-346138-ip42zcld | In particular, it is necessary to understand when the SARS- CoV-2 positive subject is capable of infecting others or when this possibility is greater? |
| cord-346138-ip42zcld | In which biological materials is the virus present and in what quantities? |
| cord-349684-2tioh80m | How Long Do Nosocomial Pathogens Persist on Inanimate Surfaces? |
| cord-342756-rgm9ffpk | -What happens next? |
| cord-342756-rgm9ffpk | : what to expect for COVID-19? |
| cord-342756-rgm9ffpk | COVID-19 and diabetes: Can DPP4 inhibition play a role? |
| cord-342756-rgm9ffpk | COVID-19, SARS and MERS: are they closely related? |
| cord-342756-rgm9ffpk | DPP4 inhibition: preventing SARS- CoV-2 infection and/or progression of COVID-19? |
| cord-342756-rgm9ffpk | Protein- protein interactions of viroporins in coronaviruses and paramyxoviruses: new targets for antivirals? |
| cord-342756-rgm9ffpk | The importance of hypertension as a risk factor for severe illness and mortality in COVID-19 Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study Diabetes is a risk factor for the progression and prognosis of COVID-19 Older people and COVID-19: isolation, risk and ageism Asymptomatic carriers of COVID-19 as a concern for disease prevention and control: more testing, more follow- up Drug repositioning: identifying and developing new uses for existing drugs Drug repurposing from the perspective of pharmaceutical companies Drug repurposing: progress, challenges and recommendations Emerging virus diseases: can we ever expect the unexpected? |
| cord-342756-rgm9ffpk | and COVID-19: serendipity or opportunity for intervention? |
| cord-342756-rgm9ffpk | should inhibitors of the renin- angiotensin system be withdrawn in patients with COVID-19? |
| cord-342756-rgm9ffpk | what lessons have we learned? |
| cord-347128-6lyoz8nn | More than meets the eye? |
| cord-347128-6lyoz8nn | New insights into the antiviral effects of chloroquine New insights on the antiviral effects of chloroquine against coronavirus: What to expect for COVID-19? |
| cord-347128-6lyoz8nn | Why are Oseltamivir and Zanamivir effective against the newly emerged influenza A virus( A/ H1N1)? |
| cord-348860-zaimorg0 | Kaposi's sarcoma- associated herpesvirus: a new DNA tumor virus A genomic perspective on protein families Microarrays under the microscope Microarray techniques in pathology: tool or toy? |
| cord-348860-zaimorg0 | Many experimental studies have gone into establishing the different cellular pathways modulated by the virus, and whether a common theme exists for all viruses or each virus behaves differently? |
| cord-348777-pk9y6vfp | What should the world do now? |
| cord-347710-ff64y6ef | : where do we stand? |
| cord-347710-ff64y6ef | Hsp90 inhibitors: a potential treatment for latent EBV infection? |
| cord-347710-ff64y6ef | The hepatitis E virus open reading frame 3 product interacts with microtubules and interferes with their dynamics The ins and outs of tubulin acetylation: more than just a post- translational modification? |
| cord-347710-ff64y6ef | diagnostic, prognostic, predictive, and treatment implications Altered states: selectively drugging the Hsp90 cancer chaperone Heat shock proteins promote cancer: it's a protection racket Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands? |
| cord-346916-jj4l9ydl | : what have we learned and where are we headed? |
| cord-346916-jj4l9ydl | Toll- like receptor 3 in viral pathogenesis: friend or foe? |
| cord-347472-n6811ens | Controls are useful; why not add more? |
| cord-347472-n6811ens | Why change the assay when one could fix the input? |
| cord-346853-0c1qdjb5 | Although the focus on changing human ecology and phylogenetic history was an important and necessary first step, and it will often be impossible to disentangle ecology and genetics when explaining the emergence of a specific pathogen, it is also essential to ask what evolutionary processes are responsible for the appearance and spread of pathogens? |
| cord-346853-0c1qdjb5 | Are certain types of virus more likely to emerge than others? |
| cord-346853-0c1qdjb5 | Are viruses from phylogenetically related host species more likely to undergo cross- species transmission than those viruses from distantly related host species? |
| cord-346853-0c1qdjb5 | Does viral emergence require adaptation to the new host species? |
| cord-346853-0c1qdjb5 | Is recombination a prerequisite for viral emergence? |
| cord-346853-0c1qdjb5 | Perhaps the central question in this respect is whether, following cross- species transmission, emergent viruses must adapt to replicate in their new species, or whether the process of emergence is essentially blind to natural selection? |
| cord-346853-0c1qdjb5 | Specifically, are those viruses from our closest relatives, the simian primates, more able to infect us than those from other mammalian orders? |
| cord-346853-0c1qdjb5 | The key question, therefore, is whether these mutations appear de novo in humans, in the short transmission networks of people who initially suffer avian influenza, or whether they preexist in the avian population, and if the appropriate strain is transmitted, then will emergence follow? |
| cord-346853-0c1qdjb5 | Why might this be so? |
| cord-350040-e8q7wq0h | 30, 31 What happens to the rejected strand? |
| cord-350040-e8q7wq0h | Are there strategic changes in siRNA design to improve siRNA efficacy? |
| cord-350040-e8q7wq0h | Introduction of siRNA into cells raises a theoretical concern: might exogenous siRNA compete with endogenous, intracellular mRNA silencing systems? |
| cord-350697-u032yk0z | Can concomitant use of zinc and curcumin with other immunity‐boosting nutraceuticals be the arsenal against COVID‐19? date: 2020- 06- 02 journal: |
| cord-350697-u032yk0z | Can we fit curcumin and zinc into this continuing puzzle? |
| cord-340489-yo3cp5vs | Auf Befragen gibt er an Welche Frage ist zunächst zu stellen? |
| cord-340489-yo3cp5vs | Ist die Candidapneumonie eine häufige Erkrankung? |
| cord-340489-yo3cp5vs | Sie zunächst? |
| cord-340489-yo3cp5vs | Sprosspilzinfektionen endogen oder exogen erworben? |
| cord-340489-yo3cp5vs | Untersuchung veranlasst? |
| cord-340489-yo3cp5vs | Was empfehlen Sie dem Patienten? |
| cord-340489-yo3cp5vs | Welche sind die 3 wichtigsten Antimykotika- Substanzklassen? |
| cord-340489-yo3cp5vs | Welche therapeutischen Maßnahmen sind angezeigt? |
| cord-340489-yo3cp5vs | Werden Fadenpilzinfektionen endogen oder exogen erworben? |
| cord-340489-yo3cp5vs | Wie lautet Ihre Verdachtsdiagnose? |
| cord-340489-yo3cp5vs | Wie soll man HIV- infizierte Schwangere behandeln? |
| cord-340489-yo3cp5vs | Wie wird der Patient initial behandelt? |
| cord-340489-yo3cp5vs | Windpockenerkrankungen oder eine Gingivostomatitis herpetica behandelt werden? |
| cord-340489-yo3cp5vs | b. Welche Untersuchungen werden durchgeführt? |
| cord-340489-yo3cp5vs | c. Wie wird der Patient behandelt? |
| cord-340489-yo3cp5vs | d. Was wird dem Patienten gesagt? |
| cord-340489-yo3cp5vs | einer antiretroviralen Therapie bei HIV- Infektion? |
| cord-340489-yo3cp5vs | oder häufig gegen Fluconazol resistent? |
| cord-340489-yo3cp5vs | unteren Atemwege mit Candida species? |
| cord-340489-yo3cp5vs | unterschieden? |
| cord-340489-yo3cp5vs | werden? |
| cord-340489-yo3cp5vs | werden? |
| cord-350836-1enteev7 | -I signaling Reversal of the interferon- sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA Approaching the RNA ligand for RIG- I? |
| cord-350836-1enteev7 | A novel role for viral- defective interfering particles in enhancing dendritic cell maturation Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad- spectrum antivirals? |
| cord-350836-1enteev7 | Methanococcus jannaschii Unlocking the DEAD- box: a key to cryptococcal virulence? |
| cord-351489-tzmev77c | An old drug against today's diseases? |
| cord-350747-5t5xthk6 | First, why is elongation on the first template interrupted? |
| cord-350747-5t5xthk6 | Poliovirus neurovirulence depends on the presence of a cryptic AUG upstream of the initiator codon Nonreplicative homologous RNA recombination: promiscuous joining of RNA pieces? |
| cord-350747-5t5xthk6 | Second, does the incomplete nascent strand dissociate alone or together with RdRP? |
| cord-350747-5t5xthk6 | Third, how is the site of the acceptor template chosen to resume synthesis? |
| cord-349358-leicos9j | Again, as with other drugs in development against HIV infection, we are confronted with the following major questions: what are the potential side effects from such an approach, and what would be the therapeutic dose window? |
| cord-349358-leicos9j | In other words, what would be the preferred delivery system to use in animals and later on in humans? |
| cord-351115-dy81dtnk | How much promising? |
| cord-349672-2kt7xw8i | A Novel Candidate Gene in Juvenile Myoclonic Epilepsy? |
| cord-349672-2kt7xw8i | topoisomerase I conserved for interaction with a specific cytosine base to facilitate DNA cleavage Synthesizing topological structures containing RNA Type IA topoisomerases: A simple puzzle? |
| cord-351520-c5fi2uoh | RIG- I- mediated innate antiviral signaling by the dihydroxyacetone kinase RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization Innate antiviral responses by means of TLR7-mediated recognition of single- stranded RNA Poxvirus protein N1L targets the I- kappaB kinase complex, inhibits signaling to NF- kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF- kappaB and IRF3 signaling by toll- like receptors Activation of IKK by TNFalpha requires site- specific ubiquitination of RIP1 and polyubiquitin binding by NEMO Does Toll- like receptor 3 play a biological role in virus infections? |
| cord-351520-c5fi2uoh | an in- Toll- erant protein kinase? |
| cord-351548-jvl63652 | An alternative view on an outdated hypothesis Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer? |
| cord-354536-c9v9kbw8 | The Ebola epidemic crystallizes the potential of passive antibody therapy for infectious diseases Selection of Vaccinia Virus- Neutralizing Antibody from a Phage- Display Human- Antibody Library Screening of FDA- approved drugs using a MERS- CoV clinical isolate from South Korea identifies potential therapeutic options for Passive Immunotherapy: Assessment of Convalescent Serum Against Ebola Virus Makona Infection in Nonhuman Primates Enhancement of infectivity of a non- syncytium inducing HIV-1 by sCD4 and by human antibodies that neutralize syncytium inducing HIV-1 Convalescent plasma: new evidence for an old therapeutic tool? |
| cord-350286-n7ylgqfu | Do Viral Proteins Possess Unique Features? |
| cord-350286-n7ylgqfu | Intrinsic disorderedness and functionality of HIF-1α along with its interacting proteins Why are"natively unfolded"proteins unstructured under physiologic conditions? |
| cord-351365-dc9t3vh3 | Fact or fiction? |
| cord-351365-dc9t3vh3 | What Is a Quasispecies? |
| cord-352379-q5inrxcm | On the other hand, feline coronavirus vaccines have been proven to be not only inefficacious; worse yet, the?, have been shown to lead to even more severe viral infections in the vaccinated cats[ 78]. |
| cord-347351-emdj66vj | : how much do we really know? |
| cord-347351-emdj66vj | : what does viral RNA load really mean? |
| cord-347351-emdj66vj | A Case Report Surgical mask partition reduces the risk of non- contact transmission in a golden Syrian hamster model for Coronavirus Disease 2019( COVID-19) Australian Government releases face masks to protect against coronavirus Rapid assessment of regional SARS- CoV-2 community transmission through a convenience sample of healthcare workers, the Netherlands Universal Masking in Hospitals in the Covid-19 Era Mass masking in the COVID-19 epidemic: people need guidance Covid-19: should the public wear face masks? |
| cord-347351-emdj66vj | A SARS- CoV-2 familial cluster infection reveals asymptomatic transmission to children Familial cluster of SARS- CoV-2 infection associated with a railway journey What settings have been linked to SARS- CoV-2 transmission clusters? |
| cord-347351-emdj66vj | Clinical infectious diseases: an official publication of the Infectious Diseases Society of Viral kinetics of SARS- CoV-2 in asymptomatic carriers and presymptomatic patients Clinical infectious diseases: an official publication of the Infectious Diseases Society of Viral Load Kinetics of SARS- CoV-2 Infection in First Two Patients in Korea A field indoor air measurement of SARS- CoV-2 in the patient rooms of the largest hospital in Iran Asymptomatic COVID-19 Patients Can Contaminate Their Surroundings: an Environment Sampling Study Environmental contamination by SARS- CoV-2 in a designated hospital for coronavirus disease 2019 Do established infection prevention and control measures prevent spread of SARS- CoV-2 to the hospital environment beyond the patient room? |
| cord-347351-emdj66vj | Temporal dynamics in viral shedding and transmissibility of COVID-19 Clearance and persistence of SARS- CoV-2 RNA in patients with COVID-19 Journal of clinical virology: the official publication of the Pan American Society for Airborne or droplet precautions for health workers treating COVID-19? Transmission routes of respiratory viruses among humans Aerobiology and its role in the transmission of infectious diseases Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations On air- borne infection: study II. |
| cord-347351-emdj66vj | an official publication of the Infectious Diseases Society of How will country- based mitigation measures influence the course of the COVID-19 epidemic? |
| cord-347351-emdj66vj | the Spread of the Novel Coronavirus? |
| cord-353524-3w970ycx | Therefore, is there a hope for a Q11 rapid drug to come to the market? |
| cord-353524-3w970ycx | What are the issues and chances for a rapid approval of a new medicine to treat COVID-19? |
| cord-353274-wozwpvpq | The copyright holder for this preprint this version posted Viral Kinetics and Antibody Responses in Patients with COVID-19 The Role of Antibody Testing for SARS- CoV-2: Is There One? |
| cord-355499-5vj3oasa | How do miRNAs mediate translational repression? |
| cord-352465-n746e8qt | A comparative study of small molecules targeting eIF4A Active- site inhibitors of mTOR target rapamycin- resistant outputs of mTORC1 and mTORC2 Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin- resistant Functions of mTORC1 Mass Spectrometry Analysis of a Protein Kinase CK2β Subunit Interactome Isolated from Mouse Brain by Affinity Chromatography One- thousand- and- one substrates of protein kinase CK2? |
| cord-352465-n746e8qt | More stressed out with age? |
| cord-352465-n746e8qt | a link to pathological inclusions in ALS? |
| cord-352465-n746e8qt | signaling: more than just a passing phase? |
| cord-345371-pjbviagq | : Are we asking the right questions? |
| cord-345371-pjbviagq | An Individual Patient Data Systematic Review Negative impact of hyperglycaemia on tocilizumab therapy in Covid-19 patients Tocilizumab for cytokine storm syndrome in COVID-19 pneumonia: an increased risk for candidemia? |
| cord-345371-pjbviagq | An Overview of Severe Acute Respiratory Syndrome- Coronavirus( SARS- CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad- Spectrum Therapeutic Strategy Old drugs as lead compounds for a new disease? |
| cord-345371-pjbviagq | Baricitinib: a chance to treat COVID-19? |
| cord-345371-pjbviagq | Bleeding and Thrombotic Manifestations of SARS- CoV2 Infection COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow- up Pulmonary Embolism or Pulmonary Thrombosis in COVID-19? |
| cord-345371-pjbviagq | Enteric involvement of coronaviruses: is faecal- oral transmission of SARS- CoV-2 possible? |
| cord-345371-pjbviagq | Increased cardiovascular mortality in African Americans with COVID-19 Will Complement Inhibition Be the New Target in Treating COVID-19-Related Systemic Thrombosis? |
| cord-345371-pjbviagq | Inhibitory Mechanisms A Trial of Lopinavir- Ritonavir in Adults Hospitalized with Severe Covid-19 Owa Lopinavir/ ritonavir use in Covid-19 infection: is it completely non- beneficial? |
| cord-345371-pjbviagq | Is teicoplanin a complementary treatment option for COVID-19? |
| cord-345371-pjbviagq | Justified? |
| cord-345371-pjbviagq | Teicoplanin: an alternative drug for the treatment of COVID-19? |
| cord-345371-pjbviagq | The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells Cardiac arrest caused by nafamostat mesilate Three cases of treatment with Nafamostat in elderly patients with COVID-19 pneumonia who need oxygen therapy Potential new treatment strategies for COVID-19: is there a role for bromhexine as add- on therapy? |
| cord-345371-pjbviagq | Why Are Lopinavir and Ritonavir Effective against the Newly Emerged Coronavirus 2019? |
| cord-345371-pjbviagq | Why drugs fail in clinical trials in pulmonary arterial hypertension, and strategies to succeed in the future Increased renal vascular endothelial growth factor and angiopoietins by angiotensin II infusion is mediated by both AT1 and AT2 receptors Angiotensin- I converting enzyme inhibitors as potential anti- angiogenic agents for cancer therapy Our ACE in the HOLE: Justifying the Use of Angiotensin- converting Enzyme Inhibitors as Adjuvants to Standard Chemotherapy Vascular endothelial growth factor( VEGF) in acute lung injury( ALI) and acute respiratory distress syndrome( ARDS): paradox or paradigm? |
| cord-345371-pjbviagq | Why tocilizumab could be an effective treatment for severe COVID-19? |
| cord-355075-ieb35upi | inflammasome activation: the convergence of multiple signalling pathways on ROS production? |
| cord-356115-vblgotjn | Does the analysis of MHV- A59 ts mutants help us to understand these complex processes? |
| cord-353484-q7d0ysbo | Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus( 2019-nCoV) in vitro First Case of 2019 Novel Coronavirus in the United States Compassionate Use of Remdesivir for Patients with Severe Covid-19 Remdesivir in adults with severe COVID-19: a randomised, double- blind, placebo- controlled, multicentre trial Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-353484-q7d0ysbo | What Do We Know? |
| cord-353703-u86ggw11 | How does the stressed out ER find relief during virus infection? |
| cord-353290-1wi1dhv6 | Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses? |
| cord-354824-7fdcu2f0 | Evaluation of the efficacy and safety of sarilumab in hospitalized patients with COVID-19 Overview of the IL-1 family in innate inflammation and acquired immunity Personalised immunotherapy for SARS- CoV-2( COVID-19) associated with organ dysfunction Clinical course and outcomes of critically ill patients with SARS- CoV-2 pneumonia in Wuhan, China: a single- centered, retrospective, observational study Clinical characteristics of coronavirus disease 2019 in China Clinical characteristics of 140 patients infected with SARS- CoV-2 in Wuhan Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-354824-7fdcu2f0 | Investigating mechanism of Qingfei Dayuan granules for treatment of COVID-19 based on network pharmacology and molecular docking Study on screening potential traditional Chinese medicines against 2019-nCoV based on Mpro and PLP Chinese herbal medicine for severe acute respiratory syndrome: a systematic review and metaanalysis Traditional Chinese herbal medicine as a source of molecules with antiviral activity Can Chinese medicine be used for prevention of corona virus disease 2019( COVID-19)? |
| cord-354824-7fdcu2f0 | The host immune response in respiratory virus infection: balancing virus clearance and immunopathology Groups at higher risk for severe illness Coronavirus and COVID-19: who is at higher risk? |
| cord-354824-7fdcu2f0 | Why tocilizumab could be an effective treatment for severe COVID-19? |
| cord-354824-7fdcu2f0 | identifies potential anti- coronavirus drugs Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus Meta- analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? |
| cord-354582-fniymnmf | The SARS, MERS and novel coronavirus( COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? |
| cord-356009-emn2w8if | : Does SARS- CoV-2 Cause Viral Cystitis? |
| cord-356009-emn2w8if | However, it is important to notice that it is the naso- pharyngeal specimens,? |
| cord-356009-emn2w8if | Moreover, the findings in our review? suggest that a larger population size may reveal more positive urinary cases possibly by? |
| cord-356009-emn2w8if | Moreover, the findings in our review? suggest that a larger population size may reveal more positive urinary cases possibly by? |
| cord-356009-emn2w8if | Our review concludes that not only the SARS- CoV-2 can be excreted in the urine in eight? |
| cord-356009-emn2w8if | What Specimen Urologists Should Be Most Concerned About? |
| cord-356009-emn2w8if | What kind of systematic review should I conduct? |
| cord-356009-emn2w8if | percent of patients but also its incidence may have associations with the severity of the? systemic disease, ICU admission, and fatality rates. |
| cord-356013-pl3tmky8 | ( Khromykh et al. 1999)? |
| cord-356013-pl3tmky8 | Between replication and transcription? |
| cord-356013-pl3tmky8 | Do these higher- order structures bind viral or cellular proteins? |
| cord-356013-pl3tmky8 | Do these represent the bona fide packaging signals for the viral genome? |
| cord-356013-pl3tmky8 | Do they play a role in initiating or regulating plus- strand synthesis? |
| cord-356013-pl3tmky8 | Does the evidence of resistance of coronaviral RNAs to ribonuclease suggest existence of a compartmentalized replication complex and have implications for resistance to RNA silencing( Ahlquist 2002) and long- term persistent coronaviral infections( Adami et al. 1995; Baric et al. 1999; Okumura et al. 1996; Stohlman et al. 1999)? |
| cord-356013-pl3tmky8 | Does the intra-5 0 UTR short ORF play a role in translation( or in subsequent replication) of the genome? |
| cord-356013-pl3tmky8 | Does this structure represent a cis- acting replication signal required for replication of the intact genome? |
| cord-356013-pl3tmky8 | How is the genome selected and transported from the replication complex to the site of virus assembly? |
| cord-356013-pl3tmky8 | How might they differ between the processes of minus- and plusstrand synthesis? |
| cord-356013-pl3tmky8 | If it is altered, what might the consequences be on virus growth? |
| cord-356013-pl3tmky8 | If so, what role does it play in the regulation of genome replication? |
| cord-356013-pl3tmky8 | In addition to the N protein( Laude and Masters 1995), might the packaging signals interact with other components of the virion? |
| cord-356013-pl3tmky8 | Is a specific sequence alone sufficient, or are higher- order structures required? |
| cord-356013-pl3tmky8 | Is there perhaps more than one packaging signal, as suggested by the ability of more than a single region of ORF 1b to contribute to packaging efficiency in large TGEV DI RNAs( Izeta et al. 1999)? |
| cord-356013-pl3tmky8 | Is this property of N common to all coronaviruses? |
| cord-356013-pl3tmky8 | Might pathogenesis be altered such that the variants could be used as vaccines or vectors for other uses? |
| cord-356013-pl3tmky8 | Might they be signals working through long- distance RNA- RNA or RNA- protein interactions? |
| cord-356013-pl3tmky8 | Stirrups et al. 2000)? |
| cord-356013-pl3tmky8 | Therefore, what features enable the replication of the DI RNAs but not sgmRNAs on transfection into helper virus- infected cells? |
| cord-356013-pl3tmky8 | What genes are important in regulation of replication and transcription, and how important is gene order in these processes? |
| cord-356013-pl3tmky8 | What is the nature of the terminal cis- acting RNA elements? |
| cord-356013-pl3tmky8 | What is the relationship between the RNA replication complex and the site of virus assembly at the Golgi and intermediate Golgi membranes? |
| cord-356013-pl3tmky8 | What is the significance of this gene order? |
| cord-356013-pl3tmky8 | What is the stoichiometry of the components in the various complexes? |
| cord-356013-pl3tmky8 | Which proteins bind the RNA, both genomic and subgenomic, both plus and minus strands, within the complex? |