This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.
trigram | frequency |
---|---|
as well as | 539 |
the presence of | 516 |
in order to | 427 |
of the peptide | 393 |
the development of | 336 |
one of the | 312 |
based on the | 305 |
the use of | 289 |
due to the | 254 |
the formation of | 245 |
in the presence | 238 |
the synthesis of | 232 |
structure of the | 212 |
it has been | 176 |
a variety of | 175 |
in this study | 174 |
of the protein | 174 |
the role of | 164 |
of the peptides | 162 |
the effect of | 161 |
a number of | 160 |
found to be | 158 |
herpes simplex virus | 155 |
been shown to | 153 |
amino acid residues | 152 |
the design of | 148 |
the mechanism of | 146 |
h h h | 145 |
the treatment of | 145 |
in addition to | 140 |
the structure of | 139 |
the number of | 136 |
analysis of the | 135 |
of these peptides | 133 |
can be used | 131 |
involved in the | 128 |
the identification of | 126 |
the activity of | 123 |
was found to | 120 |
has been shown | 119 |
a series of | 117 |
derived from the | 117 |
the case of | 116 |
the surface of | 116 |
human immunodeficiency virus | 114 |
and in vivo | 113 |
activity of the | 113 |
of the most | 113 |
on the other | 110 |
of antimicrobial peptides | 107 |
the ability to | 107 |
mechanism of action | 107 |
with respect to | 107 |
in vitro and | 107 |
the production of | 107 |
in the case | 106 |
formyl peptide receptor | 106 |
and characterization of | 105 |
peptides and proteins | 104 |
the amino acid | 104 |
the other hand | 103 |
shown to be | 102 |
the absence of | 102 |
well as the | 101 |
to determine the | 100 |
in the present | 100 |
of amino acid | 100 |
the importance of | 99 |
vitro and in | 99 |
for the development | 98 |
as a result | 98 |
severe acute respiratory | 97 |
the effects of | 97 |
according to the | 96 |
for the treatment | 96 |
crystal structure of | 96 |
are able to | 95 |
acute respiratory syndrome | 95 |
to be a | 95 |
to investigate the | 95 |
role in the | 94 |
was used to | 94 |
the interaction of | 94 |
peptides derived from | 94 |
of the human | 93 |
of the two | 92 |
have shown that | 92 |
the active site | 92 |
there is a | 91 |
that can be | 91 |
in this work | 91 |
the ability of | 91 |
phase peptide synthesis | 91 |
the aim of | 90 |
host defence peptides | 89 |
amino acid sequence | 89 |
is one of | 89 |
part of the | 88 |
in which the | 88 |
properties of the | 88 |
the binding of | 88 |
such as the | 88 |
of the membrane | 88 |
an important role | 87 |
of amino acids | 87 |
cov cl pro | 86 |
on the surface | 86 |
is based on | 85 |
were found to | 84 |
in the absence | 83 |
the present study | 83 |
responsible for the | 83 |
corresponding to the | 82 |
be used to | 81 |
binding to the | 81 |
important role in | 81 |
a range of | 80 |
have been identified | 78 |
changes in the | 77 |
of a novel | 77 |
of a peptide | 76 |
a set of | 76 |
of action of | 76 |
and in the | 76 |
to study the | 75 |
to that of | 75 |
region of the | 75 |
wide range of | 74 |
at the n | 74 |
showed that the | 74 |
the expression of | 74 |
peptides have been | 74 |
the results of | 74 |
interaction with the | 74 |
simplex virus type | 74 |
present in the | 73 |
used as a | 73 |
was carried out | 72 |
of the c | 72 |
peptides in the | 72 |
has also been | 72 |
in contrast to | 72 |
that of the | 72 |
most of the | 71 |
have been used | 71 |
of the n | 71 |
can also be | 71 |
amino acids in | 71 |
of peptides and | 70 |
the interaction between | 70 |
in the development | 70 |
sequence of the | 70 |
surface of the | 70 |
in response to | 70 |
were able to | 69 |
due to its | 69 |
at the c | 69 |
compared to the | 69 |
have been developed | 69 |
used for the | 68 |
the discovery of | 68 |
the detection of | 68 |
the sequence of | 68 |
the application of | 67 |
used in the | 67 |
biological activity of | 67 |
a wide range | 67 |
was supported by | 67 |
of a protein | 67 |
a combination of | 67 |
in the peptide | 67 |
immunodeficiency virus type | 66 |
have also been | 66 |
will be presented | 66 |
understanding of the | 66 |
are involved in | 66 |
amino acids and | 65 |
the analysis of | 65 |
peptides from the | 65 |
residues in the | 65 |
in terms of | 65 |
is able to | 64 |
nature of the | 64 |
of the target | 64 |
presence of the | 64 |
amino acid sequences | 64 |
an increase in | 64 |
to improve the | 63 |
to interact with | 63 |
of the enzyme | 63 |
suggest that the | 63 |
we found that | 63 |
depending on the | 62 |
the cell membrane | 62 |
in the p | 62 |
due to their | 62 |
peptide derived from | 62 |
was shown to | 62 |
role of the | 62 |
the activation of | 62 |
be used for | 61 |
characterization of the | 61 |
at room temperature | 61 |
related to the | 61 |
the lack of | 60 |
to be the | 60 |
the basis of | 60 |
effect on the | 60 |
and can be | 60 |
isolated from the | 60 |
is the most | 60 |
of this study | 60 |
in combination with | 59 |
because of the | 59 |
domain of the | 59 |
for the synthesis | 59 |
by means of | 59 |
antimicrobial activity of | 59 |
these peptides are | 59 |
the release of | 58 |
the plasma membrane | 58 |
the venom of | 58 |
the nature of | 58 |
in recent years | 58 |
been used to | 58 |
from the venom | 57 |
effect of the | 57 |
for the design | 57 |
some of the | 57 |
characterization of a | 57 |
to identify the | 57 |
the addition of | 57 |
found in the | 56 |
in the same | 56 |
has been used | 56 |
associated with the | 56 |
were used to | 56 |
solid phase peptide | 56 |
the antimicrobial peptide | 56 |
the regulation of | 56 |
based on a | 56 |
their ability to | 56 |
the majority of | 56 |
presence of a | 55 |
the study of | 55 |
found that the | 55 |
the fact that | 55 |
revealed that the | 55 |
of the sars | 55 |
appears to be | 55 |
led to the | 54 |
been found to | 54 |
this work was | 54 |
large number of | 54 |
to evaluate the | 54 |
the concentration of | 54 |
formation of a | 54 |
show that the | 53 |
molecular dynamics simulations | 53 |
have been shown | 53 |
the spike protein | 53 |
in the range | 52 |
phage display technology | 52 |
in the brain | 52 |
as shown in | 52 |
stability of the | 52 |
demonstrated that the | 52 |
interact with the | 52 |
to increase the | 52 |
the incorporation of | 52 |
the function of | 52 |
the peptides were | 51 |
the introduction of | 51 |
will be discussed | 51 |
to understand the | 51 |
a role in | 51 |
are known to | 51 |
the secondary structure | 51 |
of the viral | 51 |
at the same | 51 |
peptides can be | 51 |
binding of the | 50 |
of a new | 50 |
we have developed | 50 |
the generation of | 50 |
be used as | 50 |
the crystal structure | 50 |
the amount of | 50 |
a large number | 50 |
mode of action | 50 |
the biological activity | 49 |
length of the | 49 |
function of the | 49 |
the rate of | 49 |
between the two | 49 |
structure and function | 49 |
was able to | 48 |
aim of this | 48 |
in the cell | 48 |
of the three | 48 |
which is a | 48 |
to assess the | 48 |
formation of the | 48 |
of the amino | 48 |
a result of | 48 |
to inhibit the | 48 |
central nervous system | 48 |
of the virus | 48 |
fmdv c pro | 48 |
development of new | 47 |
in the literature | 47 |
which can be | 47 |
of herpes simplex | 47 |
the potential of | 47 |
on the basis | 47 |
to form a | 47 |
the p position | 47 |
structures of the | 47 |
were synthesized by | 47 |
we report the | 47 |
interactions between the | 47 |
development of a | 47 |
increase in the | 47 |
were carried out | 46 |
it was found | 46 |
the side chain | 46 |
supported by the | 46 |
shown that the | 46 |
some of these | 46 |
the fi rst | 46 |
play an important | 46 |
study was to | 46 |
each of the | 46 |
the stability of | 46 |
this study was | 46 |
synthesis of the | 46 |
proteins and peptides | 46 |
to bind to | 46 |
be involved in | 45 |
the inhibition of | 45 |
of the cell | 45 |
the preparation of | 45 |
the delivery of | 45 |
has been demonstrated | 45 |
mechanisms of action | 45 |
results suggest that | 45 |
and it is | 44 |
structural and functional | 44 |
to the peptide | 44 |
peptides and their | 44 |
the most potent | 44 |
is involved in | 44 |
a mixture of | 44 |
the context of | 44 |
the possibility of | 44 |
has not been | 44 |
the most important | 44 |
the field of | 44 |
the structure and | 44 |
the influence of | 44 |
amino acid composition | 44 |
respect to the | 44 |
is required for | 44 |
for min at | 43 |
member of the | 43 |
in the treatment | 43 |
activation of the | 43 |
venom of the | 43 |
it is possible | 43 |
in the field | 43 |
regions of the | 43 |
antimicrobial peptides from | 43 |
have been reported | 43 |
similar to that | 43 |
the in vivo | 43 |
was used as | 43 |
of the binding | 43 |
the most common | 43 |
be used in | 43 |
lead to the | 42 |
suggested that the | 42 |
of the antimicrobial | 42 |
the process of | 42 |
focused on the | 42 |
leading to the | 42 |
is an important | 42 |
conformation of the | 42 |
we show that | 42 |
the results obtained | 42 |
than that of | 42 |
there is no | 42 |
is responsible for | 42 |
the range of | 42 |
interaction of the | 42 |
of proteins and | 42 |
the binding site | 42 |
the level of | 42 |
of the bilayer | 41 |
synthesis of a | 41 |
it can be | 41 |
the antimicrobial activity | 41 |
consistent with the | 41 |
known to be | 41 |
p and p | 41 |
identification of a | 41 |
as a model | 41 |
the action of | 41 |
in a mouse | 41 |
change in the | 41 |
work was supported | 41 |
as compared to | 41 |
results show that | 41 |
active site of | 40 |
differences in the | 40 |
indicate that the | 40 |
was found that | 40 |
side of the | 40 |
for h at | 40 |
dependent on the | 40 |
the prediction of | 40 |
in patients with | 40 |
size of the | 40 |
tandem mass spectrometry | 40 |
has been developed | 40 |
to predict the | 40 |
secondary structure of | 40 |
shown in figure | 40 |
the growth of | 40 |
has been found | 39 |
it is a | 39 |
effects of the | 39 |
aichi h n | 39 |
of the complex | 39 |
located in the | 39 |
to be used | 39 |
attached to the | 39 |
studies of the | 39 |
is composed of | 39 |
it is not | 39 |
the present work | 39 |
to the formation | 39 |
of the lipid | 39 |
the peptide and | 39 |
in this context | 39 |
of the proteins | 38 |
terminus of the | 38 |
as a consequence | 38 |
it is also | 38 |
mechanism of the | 38 |
observed in the | 38 |
the characterization of | 38 |
an antimicrobial peptide | 38 |
has been proposed | 38 |
in escherichia coli | 38 |
the in vitro | 38 |
this study we | 38 |
have been found | 38 |
we investigated the | 38 |
bind to the | 38 |
antimicrobial activity against | 38 |
of this peptide | 38 |
the interaction with | 38 |
and function of | 38 |
added to the | 38 |
respiratory syndrome coronavirus | 38 |
cell penetrating peptides | 38 |
design of a | 38 |
contribute to the | 38 |
end of the | 38 |
antimicrobial peptides in | 37 |
be able to | 37 |
able to inhibit | 37 |
the peptide is | 37 |
is known to | 37 |
to be more | 37 |
viral fusion proteins | 37 |
use of the | 37 |
seems to be | 37 |
the innate immune | 37 |
of the s | 37 |
is essential for | 37 |
proved to be | 37 |
that the peptide | 37 |
in the membrane | 37 |
the synthesis and | 37 |
amino acids are | 37 |
could be used | 37 |
structure of a | 37 |
are based on | 36 |
addition to the | 36 |
have been described | 36 |
new class of | 36 |
it was shown | 36 |
insight into the | 36 |
of the major | 36 |
of the structure | 36 |
peptide and protein | 36 |
interaction between the | 36 |
to elucidate the | 36 |
here we present | 36 |
depends on the | 36 |
been identified in | 36 |
is due to | 36 |
the size of | 36 |
of the hiv | 36 |
the amino acids | 36 |
for the first | 36 |
this is the | 36 |
the lipid bilayer | 36 |
of the innate | 36 |
antiviral activity of | 36 |
well as in | 36 |
for the detection | 36 |
followed by a | 36 |
results indicate that | 36 |
and biological activity | 36 |
were used as | 35 |
to the n | 35 |
all of the | 35 |
identification of the | 35 |
in the apd | 35 |
is used to | 35 |
we have shown | 35 |
leads to the | 35 |
is a key | 35 |
insights into the | 35 |
a and b | 35 |
core of the | 35 |
members of the | 35 |
the host cell | 35 |
by using the | 35 |
the conformation of | 35 |
was added to | 35 |
in complex with | 35 |
been demonstrated to | 35 |
by mass spectrometry | 35 |
that have been | 35 |
peptides were synthesized | 35 |
rational design of | 35 |
in aqueous solution | 35 |
these peptides were | 35 |
information on the | 35 |
the determination of | 35 |
key role in | 35 |
are shown in | 35 |
a total of | 35 |
is important to | 35 |
cellular uptake of | 34 |
is associated with | 34 |
in the context | 34 |
peptide from the | 34 |
antimicrobial peptides and | 34 |
have to be | 34 |
the wild type | 34 |
of peptides with | 34 |
on the structure | 34 |
determination of the | 34 |
a key role | 34 |
we developed a | 34 |
a mouse model | 34 |
ce and cec | 34 |
peptides corresponding to | 34 |
referred to as | 34 |
the immune system | 34 |
also known as | 34 |
for this purpose | 34 |
was determined by | 34 |
the phage display | 34 |
in the design | 34 |
to the presence | 34 |
has been reported | 34 |
the potential to | 34 |
hepatitis c virus | 34 |
due to a | 33 |
likely to be | 33 |
broad range of | 33 |
we present the | 33 |
wide variety of | 33 |
the ct peptide | 33 |
components of the | 33 |
in the last | 33 |
and in vitro | 33 |
it should be | 33 |
the course of | 33 |
of a single | 33 |
the loss of | 33 |
solid phase synthesis | 33 |
a group of | 33 |
of the spike | 33 |
indicated that the | 33 |
its ability to | 33 |
resulted in the | 33 |
a family of | 33 |
different types of | 33 |
the central nervous | 33 |
of the a | 33 |
identified in the | 33 |
of the native | 33 |
need to be | 33 |
studies have shown | 32 |
peptides on the | 32 |
it is important | 32 |
substrate specificity of | 32 |
hydrophobic amino acids | 32 |
applied to the | 32 |
to reduce the | 32 |
form of the | 32 |
orientation of the | 32 |
for binding to | 32 |
we were able | 32 |
the properties of | 32 |
the impact of | 32 |
in some cases | 32 |
the spike glycoprotein | 32 |
one or more | 32 |
have been proposed | 32 |
effects on the | 32 |
obtained from the | 32 |
in the n | 32 |
the first time | 32 |
the viral envelope | 32 |
peptide and the | 32 |
cleavage of the | 32 |
expressed in the | 32 |
component of the | 32 |
that it is | 32 |
study of the | 32 |
of host defence | 32 |
designed and synthesized | 32 |
the combination of | 32 |
the length of | 32 |
the target protein | 32 |
studies on the | 32 |
compared with the | 32 |
comparison of the | 31 |
in the human | 31 |
appear to be | 31 |
plays an important | 31 |
seem to be | 31 |
native chemical ligation | 31 |
amino acid residue | 31 |
results in the | 31 |
of synthetic peptides | 31 |
to play a | 31 |
the v loop | 31 |
a member of | 31 |
a wide variety | 31 |
use of a | 31 |
in the regulation | 31 |
mutations in the | 31 |
the same time | 31 |
activity of a | 31 |
the immune response | 31 |
investigation of the | 31 |
method for the | 31 |
suggesting that the | 31 |
when compared to | 31 |
the construction of | 31 |
the need for | 31 |
caused by the | 31 |
residues of the | 31 |
has been suggested | 31 |
surface plasmon resonance | 31 |
contrast to the | 31 |
is the first | 31 |
play a role | 31 |
shown in fig | 31 |
considered to be | 31 |
importance of the | 31 |
the possibility to | 30 |
the peptide was | 30 |
in comparison to | 30 |
ability of the | 30 |
been widely used | 30 |
the interactions between | 30 |
close to the | 30 |
sequences of the | 30 |
the cell surface | 30 |
characterized by a | 30 |
to be an | 30 |
suggests that the | 30 |
carried out by | 30 |
specificity of the | 30 |
been shown that | 30 |
of biologically active | 30 |
is related to | 30 |
the sequences of | 30 |
a panel of | 30 |
results showed that | 30 |
model of the | 30 |
our understanding of | 30 |
nuclear magnetic resonance | 30 |
based on their | 30 |
features of the | 30 |
interacting with the | 30 |
amino acids with | 30 |
site of the | 30 |
with high affinity | 30 |
of human immunodeficiency | 29 |
were tested for | 29 |
to be involved | 29 |
the peptide sequence | 29 |
belongs to the | 29 |
many of the | 29 |
the assembly of | 29 |
of the substrate | 29 |
with the peptide | 29 |
and amino acid | 29 |
of peptides in | 29 |
were shown to | 29 |
the peptide to | 29 |
acts as a | 29 |
which is the | 29 |
of the interaction | 29 |
be due to | 29 |
a synthetic peptide | 29 |
located at the | 29 |
of the resulting | 29 |
resulted in a | 29 |
in the protein | 29 |
proteins involved in | 29 |
diseases such as | 29 |
is mediated by | 29 |
for in vivo | 29 |
high degree of | 29 |
these results suggest | 29 |
expression of the | 29 |
positive and gram | 29 |
are present in | 29 |
have been widely | 29 |
that has been | 29 |
to develop a | 29 |
interest in the | 29 |
formyl peptide receptors | 28 |
been developed for | 28 |
in case of | 28 |
the distribution of | 28 |
of the present | 28 |
in the formation | 28 |
van der waals | 28 |
in the first | 28 |
assembly of the | 28 |
the purpose of | 28 |
was used for | 28 |
as a potential | 28 |
by the presence | 28 |
for the preparation | 28 |
identifi cation of | 28 |
side chain of | 28 |
de novo design | 28 |
over the past | 28 |
has to be | 28 |
there is an | 28 |
because of their | 28 |
the peptide in | 28 |
laser desorption ionization | 28 |
to the target | 28 |
we have synthesized | 28 |
may lead to | 28 |
is a potent | 28 |
in the past | 28 |
by using a | 28 |
the result of | 28 |
concentration of the | 28 |
we showed that | 28 |
for the identification | 28 |
were prepared by | 28 |
the most promising | 28 |
to the cell | 28 |
of npy npf | 27 |
the specificity of | 27 |
to characterize the | 27 |
modification of the | 27 |
crystal structures of | 27 |
to analyze the | 27 |
development of the | 27 |
the degree of | 27 |
structural characterization of | 27 |
single amino acid | 27 |
interactions with the | 27 |
in a single | 27 |
in the c | 27 |
are responsible for | 27 |
its interaction with | 27 |
to obtain a | 27 |
peptides with the | 27 |
for the delivery | 27 |
a class of | 27 |
we have designed | 27 |
on the peptide | 27 |
the peptides are | 27 |
a broad range | 27 |
the formyl peptide | 27 |
to the development | 27 |
isothermal titration calorimetry | 27 |
the position of | 27 |
has been widely | 27 |
amino acid substitutions | 27 |
in this case | 27 |
be considered as | 27 |
we have recently | 27 |
the involvement of | 27 |
essential for the | 27 |
with the aim | 27 |
a amino acid | 27 |
size exclusion chromatography | 27 |
is that the | 26 |
and has been | 26 |
proteins in the | 26 |
high affi nity | 26 |
was applied to | 26 |
as in the | 26 |
in vivo studies | 26 |
innate immune system | 26 |
position of the | 26 |
in the sequence | 26 |
of the molecular | 26 |
to explore the | 26 |
a decrease in | 26 |
together with the | 26 |
based on this | 26 |
acid residues in | 26 |
by solid phase | 26 |
is expressed in | 26 |
is a major | 26 |
at least two | 26 |
the substrate specificity | 26 |
is believed to | 26 |
similar to those | 26 |
between the peptide | 26 |
the hydrophobic core | 26 |
binding domain of | 26 |
data not shown | 26 |
cationic antimicrobial peptides | 26 |
evaluation of the | 26 |
of severe acute | 26 |
were obtained by | 26 |
we have used | 26 |
on the use | 26 |
proteins such as | 26 |
the cells were | 26 |
this work we | 26 |
the side chains | 26 |
assisted laser desorption | 26 |
a library of | 26 |
the separation of | 26 |
helical coiled coil | 26 |
is important for | 26 |
can be found | 26 |
to the c | 26 |
were synthesized and | 26 |
of the fusion | 26 |
of these proteins | 26 |
it is known | 26 |
of membrane proteins | 26 |
peptides and the | 26 |
has led to | 25 |
in comparison with | 25 |
the location of | 25 |
we describe the | 25 |
composed of a | 25 |
fpr and fpr | 25 |
have not been | 25 |
was shown that | 25 |
indicating that the | 25 |
with a high | 25 |
in a variety | 25 |
the filamentous phage | 25 |
in the cytoplasm | 25 |
antimicrobial activity and | 25 |
is known that | 25 |
results of the | 25 |
the affinity of | 25 |
binding site of | 25 |
a highly conserved | 25 |
peptides of the | 25 |
of the coiled | 25 |
step in the | 25 |
the folding of | 25 |
amino acids were | 25 |
belonging to the | 25 |
are characterized by | 25 |
state of the | 25 |
in the s | 25 |
because of its | 25 |
hla class ii | 25 |
protein data bank | 25 |
at least one | 25 |
regulation of the | 25 |
the mechanisms of | 25 |
is found in | 25 |
along with the | 25 |
in the second | 25 |
can lead to | 25 |
of proteins in | 25 |
a new class | 25 |
of bioactive peptides | 25 |
and that the | 25 |
the site of | 25 |
is present in | 25 |
removal of the | 25 |
derived from a | 25 |
mouse model of | 25 |
peptides such as | 25 |
cells of the | 25 |
for treatment of | 25 |
induced by the | 25 |
in animal models | 25 |
are the most | 25 |
of small molecules | 25 |
formed by the | 25 |
a consequence of | 24 |
of this work | 24 |
it may be | 24 |
can be easily | 24 |
activity against gram | 24 |
peptide in the | 24 |
the peptide backbone | 24 |
specific for the | 24 |
analysis of a | 24 |
an attempt to | 24 |
it is well | 24 |
and identification of | 24 |
resulting in a | 24 |
background and aims | 24 |
we have also | 24 |
thickness of the | 24 |
they can be | 24 |
been proposed to | 24 |
antibacterial activity of | 24 |
by phage display | 24 |
and mass spectrometry | 24 |
some of them | 24 |
better understanding of | 24 |
the evolution of | 24 |
inhibitory activity of | 24 |
activity of these | 24 |
to be effective | 24 |
similar to the | 24 |
basis of the | 24 |
are essential for | 24 |
based on these | 24 |
biologically active peptides | 24 |
synthesis of peptides | 24 |
in vivo and | 24 |
of these compounds | 24 |
development of novel | 24 |
carried out on | 24 |
which has been | 24 |
of the phage | 24 |
these results are | 24 |
the university of | 24 |
chemical synthesis of | 24 |
low molecular weight | 24 |
the peptide array | 24 |
act as a | 24 |
of the main | 24 |
the interactions of | 24 |
out of the | 24 |
peptide inhibitors of | 24 |
interfere with the | 24 |
peptides isolated from | 24 |
hydroxysteroid dehydrogenase type | 24 |
in our laboratory | 24 |
a critical role | 24 |
we propose that | 24 |
which may be | 24 |
there are two | 24 |
for the presence | 24 |
at a concentration | 24 |
the pathogenesis of | 24 |
of the same | 24 |
of this approach | 24 |
majority of the | 24 |
the two peptides | 24 |
determined by the | 23 |
the structural and | 23 |
mediated by the | 23 |
bound to the | 23 |
able to bind | 23 |
activity in the | 23 |
used as the | 23 |
for the production | 23 |
the performance of | 23 |
may be a | 23 |
side chains of | 23 |
to examine the | 23 |
have been investigated | 23 |
the occurrence of | 23 |
critical role in | 23 |
peptide nucleic acids | 23 |
sequence of a | 23 |
we demonstrated that | 23 |
and the peptide | 23 |
shown to have | 23 |
and the other | 23 |
and the c | 23 |
to be highly | 23 |
inhibition of the | 23 |
is supported by | 23 |
shows that the | 23 |
the end of | 23 |
were used for | 23 |
be responsible for | 23 |
proven to be | 23 |
unnatural amino acids | 23 |
design of new | 23 |
light on the | 23 |
in the central | 23 |
of peptides that | 23 |
for use in | 23 |
approved by the | 23 |
exposed to the | 23 |
of the receptor | 23 |
used in this | 23 |
demonstrated to be | 23 |
the advantage of | 23 |
knowledge of the | 23 |
and for the | 23 |
have been synthesized | 23 |
and synthesis of | 23 |
design and synthesis | 23 |
the cell wall | 23 |
and of the | 23 |
the basis for | 23 |
here we report | 23 |
an example of | 23 |
the percentage of | 23 |
acids in the | 23 |
to obtain the | 23 |
from the skin | 23 |
we used the | 23 |
therapeutic potential of | 23 |
is a powerful | 23 |
residues on the | 23 |
transmission electron microscopy | 23 |
is characterized by | 23 |
the design and | 23 |
results in a | 22 |
the contribution of | 22 |
the solid phase | 22 |
to the protein | 22 |
for the peptide | 22 |
were subjected to | 22 |
in the study | 22 |
relies on the | 22 |
in the early | 22 |
to the membrane | 22 |
a high degree | 22 |
view of the | 22 |
has been applied | 22 |
and have been | 22 |
duchenne muscular dystrophy | 22 |
mass spectrometry and | 22 |
is possible to | 22 |
important for the | 22 |
hydrophobic thickness of | 22 |
to those of | 22 |
a concentration of | 22 |
could be a | 22 |
and on the | 22 |
is likely to | 22 |
the changes in | 22 |
of the transmembrane | 22 |
the de novo | 22 |
of antimicrobial peptide | 22 |
phase synthesis of | 22 |
described in the | 22 |
depend on the | 22 |
the structures of | 22 |
functional characterization of | 22 |
of influenza virus | 22 |
expression of a | 22 |
with amino acid | 22 |
b and c | 22 |
information about the | 22 |
the attachment of | 22 |
been developed to | 22 |
contact with the | 22 |
recent advances in | 22 |
dynamic light scattering | 22 |
in this way | 22 |
each amino acid | 22 |
we have previously | 22 |
terminal region of | 22 |
amino acids that | 22 |
at the end | 22 |
by nmr spectroscopy | 22 |
as determined by | 22 |
this peptide is | 22 |
led to a | 22 |
mouth disease virus | 22 |
proteins have been | 22 |
is well known | 22 |
reactive oxygen species | 22 |
into the membrane | 22 |
can be obtained | 22 |
by interacting with | 22 |
be the most | 22 |
were performed in | 22 |
identified as a | 22 |
the existence of | 22 |
a crucial role | 22 |
of the drug | 22 |
broad spectrum of | 22 |
of a given | 22 |
the search for | 22 |
of at least | 22 |
should be noted | 22 |
was confirmed by | 22 |
the results are | 22 |
is represented by | 22 |
the selection of | 22 |
been reported to | 22 |
residue in the | 22 |
antimicrobial peptide ll | 22 |
the negatively charged | 21 |
potent inhibitors of | 21 |
found to have | 21 |
there has been | 21 |
be useful in | 21 |
have been studied | 21 |
in the fusion | 21 |
used to study | 21 |
we present a | 21 |
to enhance the | 21 |
structural analysis of | 21 |
for their ability | 21 |
of patients with | 21 |
fatty acyl chains | 21 |
ps peptide substrates | 21 |
terminal part of | 21 |
is also a | 21 |
to the active | 21 |
were determined by | 21 |
the availability of | 21 |
have the ability | 21 |
to the identification | 21 |
according to their | 21 |
the insertion of | 21 |
in the transmembrane | 21 |
of the sequence | 21 |
to test the | 21 |
in an attempt | 21 |
be useful for | 21 |
of viral proteins | 21 |
may not be | 21 |
that these peptides | 21 |
carried out using | 21 |
at low concentrations | 21 |
protein in the | 21 |
in this review | 21 |
of the synthetic | 21 |
molecular dynamics simulation | 21 |
our results show | 21 |
hepatitis b virus | 21 |
that could be | 21 |
belong to the | 21 |
solution structure of | 21 |
by binding to | 21 |
the linker region | 21 |
that the n | 21 |
peptide corresponding to | 21 |
be noted that | 21 |
is not a | 21 |
npy npf prrp | 21 |
to optimize the | 21 |
and development of | 21 |
was studied by | 21 |
resulting in the | 21 |
phage display libraries | 21 |
acid sequence of | 21 |
the united states | 21 |
been applied to | 21 |
was to investigate | 21 |
is dependent on | 21 |
was performed in | 21 |
been used for | 21 |
of a large | 21 |
growth factor receptor | 21 |
able to induce | 21 |
to cross the | 21 |
included in the | 21 |
cl pro cleavage | 21 |
and analysis of | 21 |
in a number | 21 |
the most active | 21 |
the molecular mechanism | 21 |
of the new | 21 |
is consistent with | 21 |
prediction of the | 21 |
the uptake of | 21 |
peptides with a | 21 |
in the process | 21 |
to the synthesis | 21 |
as an alternative | 21 |
one of these | 21 |
of both the | 21 |
observed for the | 21 |
to the surface | 21 |
antimicrobial peptide from | 21 |
the efficiency of | 21 |
required for the | 21 |
peptides that are | 21 |
the most abundant | 21 |
on the membrane | 21 |
was isolated from | 21 |
this class of | 21 |
in the viral | 21 |
it is the | 20 |
in the future | 20 |
in agreement with | 20 |
with the same | 20 |
of the molecule | 20 |
were used in | 20 |
we have studied | 20 |
characterized by the | 20 |
to the high | 20 |
difference between the | 20 |
natural amino acids | 20 |
used to identify | 20 |
the transmembrane domain | 20 |
the protein is | 20 |
high concentrations of | 20 |
peptide nucleic acid | 20 |
the hydrophobic thickness | 20 |
cancer cell lines | 20 |
has been described | 20 |
for the study | 20 |
were identified in | 20 |
delivery of sirna | 20 |
respiratory syncytial virus | 20 |
disruption of the | 20 |
with regard to | 20 |
which could be | 20 |
no effect on | 20 |
department of chemistry | 20 |
that may be | 20 |
in most cases | 20 |
the synthetic peptide | 20 |
of all the | 20 |
the peptides with | 20 |
be associated with | 20 |
data on the | 20 |
was performed by | 20 |
is similar to | 20 |
the control of | 20 |
peptides in a | 20 |
studies showed that | 20 |
was found in | 20 |
of these two | 20 |
this work is | 20 |
affinity of the | 20 |
molecular basis of | 20 |
the primary structure | 20 |
proteins can be | 20 |
been implicated in | 20 |
results from the | 20 |
in the active | 20 |
and to the | 20 |
tested for their | 20 |
was achieved by | 20 |
c and c | 20 |
of staphylococcus aureus | 20 |
the time of | 20 |
to have a | 20 |
more than one | 20 |
of viral fusion | 20 |
stabilization of the | 20 |
for drug delivery | 20 |
performance liquid chromatography | 20 |
of the hydrophobic | 20 |
for drug discovery | 20 |
of membrane fusion | 20 |
of the reaction | 20 |
thought to be | 20 |
provided by the | 20 |
by the peptide | 20 |
the understanding of | 20 |
acid sequences of | 20 |
of naturally occurring | 20 |
was performed using | 20 |
serum amyloid a | 20 |
i and ii | 20 |
release of the | 20 |
to interfere with | 20 |
as a new | 20 |
in presence of | 20 |
for the interaction | 20 |
the first step | 20 |
with that of | 20 |
novo design of | 20 |
the last decade | 20 |
cells in vitro | 20 |
of the natural | 20 |
aim of the | 20 |
potent and selective | 20 |
the mass spectrum | 20 |
from phage display | 20 |
the type of | 20 |
implicated in the | 20 |
which in turn | 20 |
approach for the | 20 |
the peptide chain | 20 |
because it is | 20 |
was observed in | 20 |
also be used | 20 |
been associated with | 20 |
in the interaction | 19 |
shared tryptic peptides | 19 |
ability to bind | 19 |
were obtained from | 19 |
can be considered | 19 |
of human beta | 19 |
we have investigated | 19 |
amino acid peptide | 19 |
is essential to | 19 |
is expected to | 19 |
amino acids to | 19 |
that the presence | 19 |
believed to be | 19 |
epidermal growth factor | 19 |
context of the | 19 |
in the rat | 19 |
well as their | 19 |
that are able | 19 |
linear and cyclic | 19 |
the head group | 19 |
agonists and antagonists | 19 |
innate immune response | 19 |
and as a | 19 |
of amps in | 19 |
to overcome this | 19 |
we have found | 19 |
a part of | 19 |
mesenchymal stem cells | 19 |
antimicrobial peptides of | 19 |
the potential for | 19 |
the orientation of | 19 |
at high concentrations | 19 |
is known about | 19 |
crucial role in | 19 |
and molecular dynamics | 19 |
the investigation of | 19 |
peptides were found | 19 |
virus type glycoprotein | 19 |
immune response to | 19 |
the hypothesis that | 19 |
phage display library | 19 |
are used in | 19 |
the human genome | 19 |
residues at the | 19 |
consists of two | 19 |
sequence in the | 19 |
ranging from to | 19 |
of phage display | 19 |
interacts with the | 19 |
by addition of | 19 |
any of the | 19 |
well as to | 19 |
in accordance with | 19 |
aim is to | 19 |
the membrane and | 19 |
were added to | 19 |
interactions of the | 19 |
the past years | 19 |
a component of | 19 |
the concept of | 19 |
location of the | 19 |
this is a | 19 |
in the lipid | 19 |
infl uence of | 19 |
order to investigate | 19 |
important roles in | 19 |
are found in | 19 |
the nt peptide | 19 |
in the current | 19 |
in the hydrophobic | 19 |
human cathelicidin ll | 19 |
peptides of interest | 19 |
is the case | 19 |
as a function | 19 |
at the p | 19 |
affi nity for | 19 |
of the immune | 19 |
in the blood | 19 |
have investigated the | 19 |
a role for | 19 |
upon binding to | 19 |
to create a | 19 |
the fusion of | 19 |
a major role | 19 |
of the non | 19 |
in the identification | 19 |
in this paper | 19 |
and it was | 19 |
the positively charged | 19 |
red blood cells | 19 |
yang et al | 19 |
of more than | 19 |
were incubated with | 19 |
response to the | 19 |
for the analysis | 19 |
found to inhibit | 19 |
amino acids of | 19 |
ms ms spectra | 19 |
the i th | 19 |
has been identified | 19 |
antiviral activity against | 19 |
has been recently | 19 |
characteristics of the | 19 |
were identified by | 19 |
inhibitors of the | 19 |
a function of | 19 |
linked to the | 19 |
major role in | 19 |
been carried out | 19 |
be important for | 19 |
the molecular basis | 18 |
such as those | 18 |
analysis showed that | 18 |
serve as a | 18 |
are required to | 18 |
the observation that | 18 |
the goal of | 18 |
of a number | 18 |
expressed in e | 18 |
the emergence of | 18 |
groups of the | 18 |
is necessary to | 18 |
is a highly | 18 |
of a series | 18 |
peptides based on | 18 |
is crucial for | 18 |
analogues of the | 18 |
studies were performed | 18 |
of them are | 18 |
on the cell | 18 |
attributed to the | 18 |
and stability of | 18 |
be found in | 18 |
parallel to the | 18 |
of the catalytic | 18 |
could also be | 18 |
in spite of | 18 |
at the surface | 18 |
is caused by | 18 |
of the first | 18 |
was obtained by | 18 |
to the discovery | 18 |
was reported to | 18 |
the modulation of | 18 |
agreement with the | 18 |
result of the | 18 |
allowed us to | 18 |
reduction of the | 18 |
observed that the | 18 |
to form the | 18 |
carried out to | 18 |
the peptides in | 18 |
cell membrane and | 18 |
cells in the | 18 |
activity in vitro | 18 |
as a template | 18 |
by inhibiting the | 18 |
resulting from the | 18 |
sars fp and | 18 |
indicates that the | 18 |
these results indicate | 18 |
in the synthesis | 18 |
bacteria and fungi | 18 |
the accumulation of | 18 |
in the production | 18 |
the increase of | 18 |
be divided into | 18 |
to act as | 18 |
ability to inhibit | 18 |
action of the | 18 |
to address this | 18 |
the substitution of | 18 |
of peptide and | 18 |
the crystal structures | 18 |
chikv e glycoprotein | 18 |
to be important | 18 |
of the model | 18 |
a new method | 18 |
is used as | 18 |
protein structure and | 18 |
is shown in | 18 |
with the highest | 18 |
is possible that | 18 |
electrostatic interactions between | 18 |
the entry of | 18 |
proteins that are | 18 |
the cellular uptake | 18 |
can be classified | 18 |
and sars ifp | 18 |
the membrane surface | 18 |
purification and characterization | 18 |
so as to | 18 |
in contact with | 18 |
useful in the | 18 |
of the original | 18 |
hydrophobic and hydrophilic | 18 |
in a dose | 18 |
affinity for the | 18 |
crucial for the | 18 |
the results from | 18 |
concentrations of the | 18 |
introduced into the | 18 |
of the active | 18 |
affi nity and | 18 |
binding site on | 18 |
shown to inhibit | 18 |
we examined the | 18 |
we used a | 18 |
the cleavage of | 18 |
conformational changes of | 18 |
new insights into | 18 |
we will present | 18 |
high levels of | 18 |
we conclude that | 18 |
was identified as | 18 |
the relationship between | 18 |
both in vitro | 18 |
in clinical trials | 18 |
this type of | 18 |
higher than the | 18 |
used to predict | 18 |
with an ic | 18 |
quantitative analysis of | 18 |
little is known | 18 |
to generate a | 18 |
the antibacterial activity | 18 |
but it is | 18 |
have demonstrated that | 18 |
amino acid side | 18 |
was based on | 18 |
there are several | 18 |
results indicated that | 18 |
influence of the | 18 |
of peptides was | 18 |
peptide synthesis and | 18 |
the mode of | 18 |
a broad spectrum | 18 |
been suggested that | 18 |
we studied the | 18 |
have been isolated | 18 |
the liquid crystalline | 18 |
been used as | 18 |
been identified as | 18 |
of the ligand | 18 |
peptides to the | 18 |
and functional characterization | 18 |
leads to a | 18 |
many of these | 18 |
approaches have been | 18 |
each of these | 18 |
may also be | 18 |
of enveloped viruses | 17 |
the cleavage site | 17 |
also able to | 17 |
been isolated from | 17 |
of the cellular | 17 |
will be used | 17 |
has recently been | 17 |
of the antibody | 17 |
of innate immunity | 17 |
that all the | 17 |
to reach the | 17 |
in the recent | 17 |
in innate immunity | 17 |
a subset of | 17 |
the fusion peptide | 17 |
the risk of | 17 |
proteins of the | 17 |
to mimic the | 17 |
sides of the | 17 |
in mammalian cells | 17 |
studies revealed that | 17 |
of the mechanism | 17 |
work was to | 17 |
intracellular delivery of | 17 |
peptide with a | 17 |
composition of the | 17 |
is in the | 17 |
the results show | 17 |
this suggests that | 17 |
at the time | 17 |
is necessary for | 17 |
cationic antimicrobial peptide | 17 |
focus on the | 17 |
on solid support | 17 |
the rational design | 17 |
on the virion | 17 |
strategy for the | 17 |
of the scorpion | 17 |
the severe acute | 17 |
of the selected | 17 |
to changes in | 17 |
endothelial growth factor | 17 |
terminal domain of | 17 |
z value of | 17 |
a model of | 17 |
the screening of | 17 |
we observed that | 17 |
of the compounds | 17 |
part of a | 17 |
viral membrane fusion | 17 |
very similar to | 17 |
the viral genome | 17 |
contributes to the | 17 |
higher than that | 17 |
we believe that | 17 |
addition of the | 17 |
vascular endothelial growth | 17 |
tool for the | 17 |
and the most | 17 |
for each of | 17 |
the efficacy of | 17 |
recent studies have | 17 |
activity of human | 17 |
has been studied | 17 |
modifi cation of | 17 |
with the cell | 17 |
have been demonstrated | 17 |
of this protein | 17 |
as described in | 17 |
that are not | 17 |
be applied to | 17 |
cd and nmr | 17 |
in the previous | 17 |
from herpes simplex | 17 |
we find that | 17 |
molecular mechanism of | 17 |
the peptide with | 17 |
amps can be | 17 |
of the helix | 17 |
were performed using | 17 |
for separation of | 17 |
as part of | 17 |
carried out in | 17 |
dynamics of the | 17 |
able to detect | 17 |
resonance energy transfer | 17 |
when compared with | 17 |
the binding affinity | 17 |
coronavirus spike protein | 17 |
even in the | 17 |
a peptide with | 17 |
the activities of | 17 |
widely used in | 17 |
introduction of the | 17 |
can be seen | 17 |
of nucleic acids | 17 |
tools for the | 17 |
applications of the | 17 |
been found in | 17 |
of the residues | 17 |
are thought to | 17 |
of a small | 17 |
of the lipids | 17 |
of the dna | 17 |
a volume of | 17 |
be related to | 17 |
conformational changes in | 17 |
properties of these | 17 |
in this process | 17 |
basis for the | 17 |
the cytoplasmic membrane | 17 |
to overcome the | 17 |
amino acid and | 17 |
group of the | 17 |
of the structural | 17 |
bovine serum albumin | 17 |
can be divided | 17 |
has been observed | 17 |
and mechanisms of | 17 |
m z value | 17 |
methods have been | 17 |
number of peptides | 17 |
design of novel | 17 |
to calculate the | 17 |
on the structural | 17 |
consists of a | 17 |
peptide array membrane | 17 |
used to determine | 17 |
the isolation of | 17 |
by circular dichroism | 17 |
terminal amino acid | 17 |
changes of the | 17 |
those of the | 17 |
of the cells | 17 |
been used in | 17 |
spectra of the | 17 |
the most widely | 17 |
by molecular dynamics | 16 |
in water and | 16 |
dynamics simulations of | 16 |
the elucidation of | 16 |
we designed a | 16 |
of the p | 16 |
in vivo in | 16 |
affected by the | 16 |
of a variety | 16 |
protein of interest | 16 |
prediction of protein | 16 |
designed based on | 16 |
alignment of the | 16 |
are associated with | 16 |
cell penetrating peptide | 16 |
taken into account | 16 |
hydrophobic length of | 16 |
the complexity of | 16 |
to the binding | 16 |
of prostate cancer | 16 |
the human cathelicidin | 16 |
strategies have been | 16 |
inhibitory activity against | 16 |
total number of | 16 |
the recognition of | 16 |
addition of a | 16 |
in the structure | 16 |
these peptides have | 16 |
reported that the | 16 |
not yet been | 16 |
there are many | 16 |
with the membrane | 16 |
yet to be | 16 |
presence of an | 16 |
the kinetics of | 16 |
drug delivery systems | 16 |
the ends of | 16 |
as shown by | 16 |
a recent study | 16 |
proof of concept | 16 |
is a promising | 16 |
the dynamics of | 16 |
a lot of | 16 |
antimicrobial peptide database | 16 |
to compare the | 16 |
was obtained from | 16 |
this approach is | 16 |
was replaced by | 16 |
the skin of | 16 |
in the following | 16 |
a better understanding | 16 |
these two peptides | 16 |
of nucleic acid | 16 |
necessary for the | 16 |
and activation of | 16 |
the last years | 16 |
associated with a | 16 |
over the last | 16 |
data suggest that | 16 |
target for the | 16 |
binding free energy | 16 |
parts of the | 16 |
the s protein | 16 |
portion of the | 16 |
and tested for | 16 |
the group of | 16 |
of the protease | 16 |
mediated delivery of | 16 |
fp and sars | 16 |
was incubated with | 16 |
able to recognize | 16 |
the selectivity of | 16 |
leading to a | 16 |
incorporated into the | 16 |
in cancer cells | 16 |
a peptide derived | 16 |
a model system | 16 |
of these new | 16 |
and dynamics of | 16 |
molecules in the | 16 |
supplemental table s | 16 |
in the pathogenesis | 16 |
innate and adaptive | 16 |
the success of | 16 |
the extent of | 16 |
also in the | 16 |
sites in the | 16 |
on the solid | 16 |
rostock h n | 16 |
face of the | 16 |
identification and characterization | 16 |
zhang et al | 16 |
the increase in | 16 |
the form of | 16 |
the aggregation of | 16 |
as the first | 16 |
h and h | 16 |
the rest of | 16 |
that there are | 16 |
an array of | 16 |
the hydrolysis of | 16 |
it would be | 16 |
to generate the | 16 |
is a very | 16 |
modulation of the | 16 |
purpose of this | 16 |
one of them | 16 |
peptide has been | 16 |
antimicrobial peptides with | 16 |
insertion of the | 16 |
these peptides to | 16 |
play a key | 16 |
the authors declare | 16 |
have been obtained | 16 |
appeared to be | 16 |
profile of the | 16 |
in the sample | 16 |
analysis of peptides | 16 |
adjacent to the | 16 |
are used to | 16 |
in our previous | 16 |
based on our | 16 |
is difficult to | 16 |
distribution of the | 16 |
development of an | 16 |
this study is | 16 |
of this enzyme | 16 |
of the parent | 16 |
have the potential | 16 |
h at room | 16 |
secondary structure and | 16 |
a significant role | 16 |
antimicrobial peptides are | 16 |
present study was | 16 |
of fusion peptides | 16 |
can be applied | 16 |
an immune response | 16 |
the inhibitory activity | 16 |
recognition of the | 16 |
an increase of | 16 |
of protein structure | 16 |
supported by a | 16 |
that they are | 16 |
antifungal activity of | 16 |
the case for | 16 |
strategies for the | 16 |
most of them | 16 |
computational design of | 16 |
to give a | 16 |
the fusion process | 16 |
orders of magnitude | 16 |
an amino acid | 16 |
influenza a virus | 16 |
have developed a | 16 |
the innate immunity | 16 |
for development of | 16 |
synthesis of peptide | 16 |
the aim to | 16 |
fusion of the | 16 |
needs to be | 16 |
of amphibian peptides | 16 |
a powerful tool | 16 |
amino group of | 16 |
in host defense | 16 |
protein kinase c | 16 |
resistant staphylococcus aureus | 16 |
in cell culture | 16 |
of the self | 16 |
were treated with | 16 |
their antimicrobial activity | 16 |
is thought to | 16 |
change of the | 16 |
we decided to | 16 |
assembly of a | 15 |
in this model | 15 |
charged amino acids | 15 |
is critical for | 15 |
and epithelial cells | 15 |
used as an | 15 |
structure and dynamics | 15 |
activities of the | 15 |
performed on a | 15 |
could not be | 15 |
for detection of | 15 |
to be considered | 15 |
for ps peptide | 15 |
islet amyloid polypeptide | 15 |
a new generation | 15 |
it was observed | 15 |
more than of | 15 |
amino acids at | 15 |
to contribute to | 15 |
widely used to | 15 |
potent inhibitor of | 15 |
role of this | 15 |
dimensional structure of | 15 |
in the liquid | 15 |
with an n | 15 |
of the anti | 15 |
lead to a | 15 |
result in a | 15 |
in the form | 15 |
shown in table | 15 |
results of this | 15 |
although it is | 15 |
shed light on | 15 |
new generation of | 15 |
which has a | 15 |
the fi nal | 15 |
not able to | 15 |
of peptides are | 15 |
case of the | 15 |
are required for | 15 |
are expected to | 15 |
to the same | 15 |
a serine protease | 15 |
one or two | 15 |
of synthetic peptide | 15 |
but not in | 15 |
the results showed | 15 |
it is worth | 15 |
were found in | 15 |
of the interactions | 15 |
structural features of | 15 |
of viral peptides | 15 |
amino acid in | 15 |
the specifi c | 15 |
is the only | 15 |
of the linker | 15 |
synthesized by solid | 15 |
activity against bacteria | 15 |
relative to the | 15 |
it is necessary | 15 |
distance between the | 15 |
the thickness of | 15 |
of negatively charged | 15 |
delivery to the | 15 |
as carriers for | 15 |
the choice of | 15 |
a model for | 15 |
to amino acids | 15 |
elucidation of the | 15 |
peptides has been | 15 |
the binding to | 15 |
the free energy | 15 |
positions of the | 15 |
conformational analysis of | 15 |
the total number | 15 |
epithelial cells and | 15 |
of dengue virus | 15 |
the distance between | 15 |
a lipid bilayer | 15 |
that in the | 15 |
by a single | 15 |
the endoplasmic reticulum | 15 |
result of a | 15 |
before and after | 15 |
recognized by the | 15 |
atomic force microscopy | 15 |
a single amino | 15 |
of the corresponding | 15 |
the difference in | 15 |
is regulated by | 15 |
and the results | 15 |
fact that the | 15 |
activity against the | 15 |
as an example | 15 |
isolation and characterization | 15 |
performed on the | 15 |
in vitro studies | 15 |
by the use | 15 |
at least three | 15 |
across the membrane | 15 |
we have been | 15 |
have been successfully | 15 |
to better understand | 15 |
contribution to the | 15 |
in figure a | 15 |
impact on the | 15 |
conjugated to a | 15 |
to develop new | 15 |
most of these | 15 |
of amyloid fibrils | 15 |
detection of the | 15 |
of peptides is | 15 |
of the b | 15 |
report the synthesis | 15 |
a novel peptide | 15 |
can be achieved | 15 |
and a peptide | 15 |
the problem of | 15 |
in vivo efficacy | 15 |
the solid support | 15 |
random peptide libraries | 15 |
we focused on | 15 |
of the sequences | 15 |
the creation of | 15 |
of these molecules | 15 |
to the brain | 15 |
and application of | 15 |
inhibitors of hiv | 15 |
in the binding | 15 |
in vitro activity | 15 |
biological activities of | 15 |
well as a | 15 |
molecular mechanisms of | 15 |
have been made | 15 |
order to improve | 15 |
structural basis of | 15 |
the protein data | 15 |
with the n | 15 |
that this peptide | 15 |
limited number of | 15 |
with severe acute | 15 |
of the latter | 15 |
on the same | 15 |
is sufficient to | 15 |
of action and | 15 |
of the central | 15 |
by measuring the | 15 |
we designed and | 15 |
hydrophobic core of | 15 |
added to each | 15 |
are important for | 15 |
the activity and | 15 |
and structure of | 15 |
of a synthetic | 15 |
were performed with | 15 |
which is an | 15 |
may be used | 15 |
that there is | 15 |
the first to | 15 |
here we describe | 15 |
for the separation | 15 |
all of these | 15 |
of the four | 15 |
and mechanism of | 15 |
the induction of | 15 |
liquid crystalline phase | 15 |
reported to be | 15 |
to confirm the | 15 |
of human diseases | 15 |
on the n | 15 |
for the binding | 15 |
a change in | 15 |
west nile virus | 15 |
of drug resistance | 15 |
share a common | 15 |
the virion surface | 15 |
evidence for the | 15 |
in clinical samples | 15 |
there is also | 14 |
to probe the | 14 |
was evaluated by | 14 |
may be useful | 14 |
in relation to | 14 |
was assessed by | 14 |
advantage of the | 14 |
the focus of | 14 |
to induce the | 14 |
previous studies have | 14 |
antimicrobial activity in | 14 |
gene expression in | 14 |
corresponds to the | 14 |
as an important | 14 |
the degradation of | 14 |
as a scaffold | 14 |
the echinoderm receptors | 14 |
amino acid analysis | 14 |
found in human | 14 |
in previous studies | 14 |
potential of the | 14 |
owing to the | 14 |
produced by the | 14 |
gao et al | 14 |
the infl uence | 14 |
is not yet | 14 |
on the market | 14 |
taking into account | 14 |
based epitope mapping | 14 |
and some of | 14 |
protein structure prediction | 14 |
conjugated to the | 14 |
their mechanism of | 14 |
able to interact | 14 |
are likely to | 14 |
the region of | 14 |
action of these | 14 |
the target cell | 14 |
an alternative to | 14 |
of the study | 14 |
also found to | 14 |
acid in the | 14 |
to the design | 14 |
are considered to | 14 |
a is a | 14 |
in conjunction with | 14 |
proteins in a | 14 |
molecular weight of | 14 |
on the molecular | 14 |
the origin of | 14 |
in vitro in | 14 |
the quality of | 14 |
was the most | 14 |
it is likely | 14 |
stages of the | 14 |
of the recombinant | 14 |
the antiviral activity | 14 |
it was also | 14 |
subunit of the | 14 |
the chemical synthesis | 14 |
have been published | 14 |
the value of | 14 |
consisting of a | 14 |
a new family | 14 |
were synthesized using | 14 |
of peptides on | 14 |
nucleic acid delivery | 14 |
for the formation | 14 |
of the antigen | 14 |
to the lack | 14 |
we tested the | 14 |
this method is | 14 |
in light of | 14 |
is the number | 14 |
that bind to | 14 |
we demonstrate that | 14 |
the most effective | 14 |
the reaction of | 14 |
of the plasma | 14 |
as a therapeutic | 14 |
the therapeutic potential | 14 |
the capability of | 14 |
in the pdb | 14 |
the internalization of | 14 |
obtained with the | 14 |
introduction of a | 14 |
detected in the | 14 |
biological activity and | 14 |
and the number | 14 |
it is believed | 14 |
parameters of the | 14 |
useful for the | 14 |
and it has | 14 |
in the nucleus | 14 |
of the synthesized | 14 |
to control the | 14 |
more potent than | 14 |
viral fusion peptides | 14 |
steric block oligonucleotides | 14 |
trichogin ga iv | 14 |
the proliferation of | 14 |
of the gh | 14 |
have found that | 14 |
desorption ionization time | 14 |
suggested to be | 14 |
as a novel | 14 |
an effi cient | 14 |
of protein folding | 14 |
we have identified | 14 |
on solid phase | 14 |
formation of an | 14 |
this peptide was | 14 |
for all the | 14 |
groups in the | 14 |
the modification of | 14 |
transmembrane ot helices | 14 |
peptide synthesis in | 14 |
that the binding | 14 |
from venom of | 14 |
an in vitro | 14 |
were selected for | 14 |
was subjected to | 14 |
has emerged as | 14 |
in living cells | 14 |
their use in | 14 |
inhibit the growth | 14 |
of the other | 14 |
of the side | 14 |
this can be | 14 |
has shown that | 14 |
insertion into the | 14 |
peptide binding to | 14 |
and its derivatives | 14 |
was monitored by | 14 |
expected to be | 14 |
and the presence | 14 |
sequence and structure | 14 |
of proteins with | 14 |
order to understand | 14 |
order to determine | 14 |
may play a | 14 |
the molecular mechanisms | 14 |
considered as a | 14 |
flight mass spectrometry | 14 |
application in the | 14 |
the outer membrane | 14 |
binding affi nity | 14 |
of our study | 14 |
host defense peptides | 14 |
synthesized by the | 14 |
identification of novel | 14 |
design of peptides | 14 |
and characterized by | 14 |
is used for | 14 |
of the predicted | 14 |
of a high | 14 |
these peptides in | 14 |
of peptides to | 14 |
been suggested to | 14 |
with the help | 14 |
production of a | 14 |
intrinsically disordered proteins | 14 |
only in the | 14 |
highly expressed in | 14 |
the naturally occurring | 14 |
room temperature for | 14 |
work is to | 14 |
peptide isolated from | 14 |
an effort to | 14 |
novel antimicrobial peptide | 14 |
delivery of a | 14 |
the advantages of | 14 |
of shared peptides | 14 |
of which are | 14 |
at sites of | 14 |
ng of viral | 14 |
amino acid with | 14 |
to provide a | 14 |
mechanism by which | 14 |
the reduction of | 14 |
with the lipid | 14 |
combinatorial peptide libraries | 14 |
the conversion of | 14 |
and evaluation of | 14 |
binding sites of | 14 |
cells and the | 14 |
high affinity for | 14 |
the help of | 14 |
on the contrary | 14 |
separation of the | 14 |
a flow rate | 14 |
in the database | 14 |
of proteins that | 14 |
characterization of two | 14 |
the presence and | 14 |
all the peptides | 14 |
compared to other | 14 |
also demonstrated that | 14 |
the development and | 14 |
development of peptide | 14 |
well as its | 14 |
interactions in the | 14 |
the decrease in | 14 |
are in the | 14 |
are the main | 14 |
version of the | 14 |
using the same | 14 |
the coupling of | 14 |
and they are | 14 |
method has been | 14 |
acting as a | 14 |
the composition of | 14 |
of peptides were | 14 |
new family of | 14 |
on the mass | 14 |
by use of | 14 |
cell membranes and | 14 |
well as for | 14 |
have been employed | 14 |
expressed protein ligation | 14 |
in human plasma | 14 |
filamentous phage as | 14 |
supported by grants | 14 |
due to an | 14 |
as a tool | 14 |
polyacrylamide gel electrophoresis | 14 |
the change in | 14 |
ad hvr epb | 14 |
capacity of the | 14 |
important in the | 14 |
of the presence | 13 |
the fusion protein | 13 |
in our group | 13 |
the hydrophobic length | 13 |
been demonstrated that | 13 |
reported in the | 13 |
of reactive oxygen | 13 |
was observed that | 13 |
a novel coronavirus | 13 |
were characterized by | 13 |
balb c mice | 13 |
to design a | 13 |
the genome of | 13 |
of these studies | 13 |
the mixture of | 13 |
that they can | 13 |
flow rate of | 13 |
the peptide bond | 13 |
hydrophobicity of the | 13 |
net charge of | 13 |
involved in a | 13 |
conformational preferences of | 13 |
obtained by the | 13 |
did not show | 13 |
good agreement with | 13 |
of gene expression | 13 |
at neutral ph | 13 |
it was demonstrated | 13 |
of the wild | 13 |
min at room | 13 |
protein interactions in | 13 |
in the host | 13 |
results were obtained | 13 |
closely related to | 13 |
than amino acids | 13 |
were observed in | 13 |
similar results were | 13 |
series of peptides | 13 |
von willebrand factor | 13 |
protein folding and | 13 |
binding properties of | 13 |
the most frequently | 13 |
targeted delivery of | 13 |
is a common | 13 |
of the different | 13 |
host cell membrane | 13 |
fl uorescence spectroscopy | 13 |
these peptides is | 13 |
to address the | 13 |
of the conjugates | 13 |
not only for | 13 |
to each well | 13 |
and showed that | 13 |
forms of the | 13 |
the identifi cation | 13 |
prepared by solid | 13 |
the method is | 13 |
data indicate that | 13 |
such as cell | 13 |
the past decade | 13 |
purifi ed by | 13 |
role played by | 13 |
are orthologs of | 13 |
analysis revealed that | 13 |
to the receptor | 13 |
has been successfully | 13 |
an ic of | 13 |
for most of | 13 |
of the bacterial | 13 |
the propensity of | 13 |
the morphology of | 13 |
for the in | 13 |
plays a role | 13 |
production of the | 13 |
applications in the | 13 |
there are no | 13 |
not only the | 13 |
the peptides to | 13 |
a signifi cant | 13 |
in an effort | 13 |
sites on the | 13 |
the thermal stability | 13 |
wang et al | 13 |
shape of the | 13 |
purity of the | 13 |
tof mass spectrometry | 13 |
critical for the | 13 |
it is interesting | 13 |
been identifi ed | 13 |
primary structure of | 13 |
uptake of the | 13 |
binding of a | 13 |
able to cross | 13 |
is a member | 13 |
into mammalian cells | 13 |
fold increase in | 13 |
play a significant | 13 |
but also to | 13 |
of the disease | 13 |
a basis for | 13 |
and so on | 13 |
well known that | 13 |
from the protein | 13 |
of the short | 13 |
in the clinical | 13 |
both in the | 13 |
the human immunodeficiency | 13 |
result in the | 13 |
the coding sequence | 13 |
study is to | 13 |
for the generation | 13 |
the inclusion of | 13 |
study we have | 13 |
incubated with the | 13 |
value of the | 13 |
binds to the | 13 |
of escherichia coli | 13 |
the peptides on | 13 |
be regarded as | 13 |
in the gel | 13 |
antimicrobial activity is | 13 |
with antimicrobial activity | 13 |
small number of | 13 |
with the protein | 13 |
studies have been | 13 |
of the known | 13 |
in the bilayer | 13 |
is a potential | 13 |
vesicular stomatitis virus | 13 |
a database of | 13 |
with and without | 13 |
of antimicrobial activity | 13 |
as building blocks | 13 |
and led to | 13 |
of each peptide | 13 |
food and drug | 13 |
binding pocket of | 13 |
the strength of | 13 |
in humans and | 13 |
the protein and | 13 |
we report on | 13 |
of peptide arrays | 13 |
using circular dichroism | 13 |
type glycoprotein h | 13 |
of interest as | 13 |
of specifi c | 13 |
the native peptide | 13 |
was performed to | 13 |
this indicates that | 13 |
decrease in the | 13 |
their structure and | 13 |
a high affinity | 13 |
in each sample | 13 |
conflict of interest | 13 |
the tertiary structure | 13 |
and the peptides | 13 |
in the liver | 13 |
isolation of a | 13 |
of the complexes | 13 |
we performed a | 13 |
the gene encoding | 13 |
be classified into | 13 |
to monitor the | 13 |
sequences in the | 13 |
activity and the | 13 |
present in a | 13 |
be present in | 13 |
plays a key | 13 |
our results suggest | 13 |
in this communication | 13 |
of the second | 13 |
the details of | 13 |
structural basis for | 13 |
the molecular level | 13 |
the evaluation of | 13 |
levels of the | 13 |
the peptide substrate | 13 |
proteins from the | 13 |
linked to a | 13 |
rest of the | 13 |
starting point for | 13 |
on the viral | 13 |
is likely that | 13 |
only a few | 13 |
formation of pores | 13 |
can be observed | 13 |
at the interface | 13 |
was analyzed by | 13 |
is determined by | 13 |
the peptide sequences | 13 |
of the isolated | 13 |
may contribute to | 13 |
the solution structure | 13 |
the levels of | 13 |
using this approach | 13 |
cells were incubated | 13 |
mutation in the | 13 |
the core of | 13 |
a novel antimicrobial | 13 |
we synthesized a | 13 |
an alternative approach | 13 |
activity of antimicrobial | 13 |
have focused on | 13 |
of hydrogen bonds | 13 |
have been designed | 13 |
and amino acids | 13 |
shown in the | 13 |
disulfi de bonds | 13 |
developed a novel | 13 |
involved in cell | 13 |
is a well | 13 |
the toxicity of | 13 |
a matter of | 13 |
new type of | 13 |
advantage of this | 13 |
huang et al | 13 |
dimensional structures of | 13 |
the gel phase | 13 |
at the molecular | 13 |
aspects of the | 13 |
are expressed in | 13 |
as described previously | 13 |
isolated from a | 13 |