bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
amino acid	970
amino acids	911
antimicrobial peptides	549
antimicrobial activity	305
antimicrobial peptide	284
mass spectrometry	269
phage display	243
peptide synthesis	194
membrane fusion	183
binding site	182
secondary structure	182
biological activity	173
solid phase	167
acid residues	163
herpes simplex	161
molecular dynamics	159
active site	157
side chain	155
simplex virus	155
virus type	145
formyl peptide	145
synthetic peptides	141
immune response	136
side chains	135
cell membrane	133
drug delivery	130
peptide receptor	130
spike protein	130
protein interactions	129
fusion proteins	127
crystal structure	124
epithelial cells	122
ms ms	122
immunodeficiency virus	120
escherichia coli	120
cell lines	118
nucleic acids	115
human immunodeficiency	114
respiratory syndrome	113
inhibitory activity	111
antiviral activity	111
filamentous phage	111
affi nity	109
peptide sequences	109
host defence	108
nucleic acid	106
penetrating peptides	105
npy npf	104
negatively charged	104
fusion peptides	103
synthetic peptide	103
peptide sequence	102
acute respiratory	100
important role	99
phase peptide	99
small molecules	99
conformational changes	99
severe acute	97
positively charged	95
influenza virus	95
peptides derived	95
cov cl	95
staphylococcus aureus	95
acid sequence	94
membrane proteins	94
defence peptides	93
cl pro	93
bioactive peptides	92
binding sites	91
immune system	90
circular dichroism	90
present study	90
negative bacteria	90
coiled coil	90
viral fusion	89
cancer cells	89
molecular weight	89
high affinity	88
antibacterial activity	87
cellular uptake	84
binding domain	83
innate immunity	83
spike glycoprotein	83
cell surface	82
naturally occurring	82
fusion protein	82
plasma membrane	82
biologically active	81
nmr spectroscopy	81
peptide libraries	80
cell line	80
mg ml	80
derived peptides	79
terminal region	79
building blocks	78
type receptors	78
cord uid	78
doc id	78
gene expression	77
growth factor	77
fi rst	76
modifi ed	76
protein structure	76
lipid bilayer	76
enveloped viruses	76
antifungal activity	75
wide range	74
fusion peptide	74
peptide inhibitors	73
substrate specificity	73
widely used	73
class ii	72
free energy	72
cell membranes	72
mammalian cells	71
drug discovery	71
clinical trials	71
cyclic peptides	70
gene delivery	70
binding affinity	68
chemical synthesis	68
immune responses	67
room temperature	67
protein folding	67
active peptides	66
terminal domain	66
like particles	66
drug resistance	66
two different	65
peptide binding	65
peptide ligands	65
cell death	65
lipid bilayers	65
wild type	65
signal transduction	65
acid sequences	65
highly conserved	65
recent years	64
monoclonal antibodies	64
serine protease	64
host defense	64
host cell	63
identifi ed	63
may also	63
mouse model	63
phase synthesis	63
peptide derived	63
electron microscopy	62
nervous system	62
peptide arrays	62
cell penetrating	62
two peptides	62
peptides containing	62
hydrogen bonds	61
epitope mapping	61
cleavage site	61
receptor binding	61
innate immune	61
helical structure	60
cell wall	60
fl uorescence	60
host cells	60
membrane protein	59
therapeutic potential	59
disulfide bonds	59
serine proteases	59
small molecule	59
positive bacteria	57
cell adhesion	57
large number	57
dynamics simulations	57
results suggest	57
mg kg	56
effi cient	56
previous studies	56
peptide substrates	56
penetrating peptide	56
disulfide bridges	56
electrostatic interactions	56
cell culture	56
rational design	56
display technology	55
type peptides	55
protein kinase	55
side effects	54
drug design	53
cell proliferation	53
target protein	53
class i	53
crystal structures	53
results obtained	53
ion channels	53
central nervous	52
net charge	52
liquid chromatography	52
wound healing	52
secondary structures	52
modifi cation	52
dendritic cells	52
antifungal peptide	52
purifi cation	52
virus entry	52
peptides may	51
virus infection	51
amyloid fibrils	51
peptide library	51
solid support	51
tandem mass	50
binding protein	50
sars fp	50
like peptides	50
peptide bond	50
viral proteins	50
cyclic peptide	50
ionic strength	50
tumor cells	50
drug development	50
purifi ed	50
results show	50
physicochemical properties	49
conformational change	49
amphibian peptides	49
breast cancer	49
monoclonal antibody	49
specifi city	49
dependent manner	49
gel electrophoresis	49
cationic antimicrobial	49
closely related	48
human beta	48
brain barrier	48
prostate cancer	48
cancer cell	48
commonly used	48
key role	48
hydrogen bonding	48
protease inhibitors	48
intrinsically disordered	48
viral entry	47
activity relationship	47
peptide chain	47
ct peptide	47
protein sequences	47
cleavage sites	47
peptide design	46
tryptic peptides	46
like peptide	46
protein interaction	46
rich peptides	46
short peptides	45
primary structure	45
acid composition	45
structure prediction	45
viral envelope	45
gene therapy	45
sequence similarity	45
type i	45
binding proteins	44
results indicate	44
derived peptide	44
heptad repeat	44
experimental data	44
animal models	44
signifi cant	44
model membranes	44
biological activities	44
acid residue	44
delivery systems	44
stem cells	44
peptide array	44
recent studies	44
ligand binding	44
transcription factors	44
recombinant protein	44
also known	43
head group	43
hydrophobic residues	43
helical conformation	43
high concentrations	43
hydrophobic core	43
peptide nucleic	43
structural analysis	43
protein design	43
present work	42
infl uence	42
viral infection	42
i ri	42
antiviral peptides	42
antimicrobial agents	42
infected cells	42
cell epitopes	42
commercially available	42
charged residues	41
dengue virus	41
enzymatic activity	41
amino group	41
protein sequence	41
therapeutic agents	41
aqueous solution	40
structural studies	40
binding peptides	40
peptide fragments	40
helical peptides	40
containing peptides	40
helical coiled	40
even though	40
kcal mol	40
transcription factor	39
cell fusion	39
performed using	39
protein complexes	39
membrane interactions	39
signaling pathways	39
directed mutagenesis	39
specific antibodies	39
sars ifp	39
also found	39
human neutrophil	39
ms analysis	38
human plasma	38
nt peptide	38
exon skipping	38
modifi cations	38
protecting groups	38
sh domain	38
structural features	38
syndrome coronavirus	38
reverse transcriptase	38
mer rpl	38
endothelial cells	38
cysteine residues	38
hydrophobic amino	38
dimensional structure	38
hydrogen bond	38
protein synthesis	37
magnetic resonance	37
van der	37
mer peptide	37
helix bundle	37
model system	37
muscular dystrophy	37
peptide concentration	37
results showed	37
chemical ligation	37
human diseases	37
three peptides	37
effi ciency	37
liquid crystalline	37
heparan sulfate	37
disulfide bond	36
human cathelicidin	36
venom peptides	36
fatty acyl	36
pore formation	36
new class	36
type ii	36
tertiary structure	36
infectious diseases	36
biological processes	36
human cytomegalovirus	36
peptide analogues	36
paneth cells	36
water molecules	35
transmembrane domain	35
peptide length	35
identifi cation	35
protein binding	35
lipid membranes	35
human neutrophils	35
high resolution	35
type neuropeptides	35
molecular mechanisms	35
unrelated peptides	35
human proteins	35
target proteins	35
protein kinases	35
functional groups	35
high throughput	35
snake venom	35
sars coronavirus	35
signal peptide	35
ng ml	35
structural changes	35
sequence homology	35
hydrophobic interactions	35
viral replication	35
target cells	35
structural information	35
membranotropic peptides	35
peptide conjugates	35
different types	34
protein structures	34
peptide receptors	34
thermal stability	34
platelet aggregation	34
protein engineering	34
full length	34
peptides corresponding	34
activity relationships	34
clinical samples	34
cationic peptides	34
outer membrane	34
fusion process	34
protease activity	34
scorpion venom	34
random coil	34
candida albicans	34
mer peptides	34
novel peptide	33
cell cycle	33
computational methods	33
previously reported	33
ps peptide	33
wide variety	33
biological functions	33
structural characterization	33
peptide substrate	33
ab initio	33
specifi cally	33
blood pressure	33
drug candidates	33
pseudomonas aeruginosa	33
broad range	33
phage library	33
light scattering	33
neurodegenerative diseases	33
formyl peptides	33
bacterial cell	32
peptide microarrays	32
peptide backbone	32
living cells	32
molecular mimicry	32
previously described	32
protein nanoparticles	32
exclusion chromatography	32
first time	32
ray crystallography	32
native chemical	32
bond formation	32
first step	32
tumor growth	32
gene transfer	32
also observed	32
positive charge	32
affinity chromatography	32
complex formation	32
eukaryotic cells	32
well known	32
amide bond	32
coat protein	32
dna binding	32
protein identification	31
molecular mass	31
broad spectrum	31
biological membranes	31
epithelial cell	31
sirna delivery	31
recombinant proteins	31
membrane disruption	31
plasmon resonance	31
inhibitory peptides	31
arginine residues	31
class iii	31
metabolic stability	31
low molecular	31
cell growth	31
natural products	31
high degree	31
multiple sclerosis	31
terminal amino	31
unnatural amino	31
surface plasmon	31
proteins involved	31
aromatic residues	31
peb gf	31
cd spectroscopy	31
fl uorescent	30
delivery system	30
throughput screening	30
novel antimicrobial	30
cell types	30
viral membrane	30
conformational analysis	30
ion channel	30
diffi cult	30
entry inhibitors	30
nuclear magnetic	30
viral peptides	30
laser desorption	30
intracellular delivery	30
nmr studies	30
antimicrobial properties	30
mm tris	30
highly specific	30
model peptides	30
small peptides	30
proteolytic cleavage	30
autoimmune diseases	30
antimicrobial activities	30
molecular basis	30
molecular modeling	30
ser thr	30
critical role	30
oxidative stress	30
biological function	30
molecular mechanism	29
protease cleavage	29
cellular processes	29
filamentous bacteriophage	29
novo design	29
carboxylic acid	29
converting enzyme	29
chain length	29
md simulations	29
size exclusion	29
dehydrogenase type	29
data set	29
amphibian amps	29
peptide amphiphiles	29
transmission electron	29
cd spectra	29
three different	29
crucial role	29
coupled receptors	29
acyl chains	29
coronavirus spike	29
united states	29
endosomal escape	29
molecular level	29
neural networks	29
structural basis	29
much higher	28
angiotensin ii	28
target cell	28
desorption ionization	28
vaccine development	28
molecular interactions	28
molecular docking	28
molar ratio	28
blood cells	28
cell lysates	28
terminal fragment	28
extracellular matrix	28
amyloid formation	28
potent inhibitors	28
nasopharyngeal swabs	28
coupling reagents	28
human cells	28
disease virus	28
defense peptides	28
bacterial infections	28
random peptide	28
hla class	28
sequence alignment	28
neutralizing antibodies	28
may lead	28
sequence analysis	28
der waals	28
type diabetes	28
glutamic acid	28
membrane surface	28
binding properties	28
low concentrations	28
western blotting	28
acid substitutions	27
biological properties	27
specific binding	27
using fmoc	27
md simulation	27
recent study	27
conventional antibiotics	27
single amino	27
small intestine	27
vivo studies	27
life cycle	27
translational modifications	27
metal ions	27
natural amino	27
point mutations	27
reperfusion injury	27
peptides isolated	27
protease inhibitor	27
taken together	27
antibacterial peptide	27
posttranslational modifications	27
isothermal titration	27
peptide classification	27
also demonstrated	27
bone marrow	27
neutralizing activity	27
cell viability	27
hela cells	27
native peptide	27
catalytic domain	27
catalytic activity	27
titration calorimetry	27
protein function	27
linear peptides	27
linker region	27
peptide structure	27
virus glycoprotein	27
signifi cantly	26
light chain	26
display libraries	26
substrate binding	26
synthesized peptides	26
assisted laser	26
coupled receptor	26
take place	26
based approach	26
data bank	26
sample preparation	26
surface area	26
rheumatoid arthritis	26
mm nacl	26
mic values	26
mouth disease	26
lipid membrane	26
modified peptides	26
peptides using	26
poorly understood	26
phage displaying	26
better understanding	26
solution structure	26
protein degradation	26
tof ms	26
type signalling	26
assembling peptide	26
coiled coils	26
antibody fragments	26
pathogenic bacteria	26
functional characterization	26
amino groups	26
least two	26
chemokine receptor	26
envelope protein	26
cell entry	26
high affi	26
hydroxysteroid dehydrogenase	26
proteolytic enzymes	25
residue peptide	25
aspartic acid	25
machine learning	25
steric block	25
least one	25
inflammatory response	25
lysine residues	25
linear peptide	25
hydrophobic thickness	25
binding motif	25
recent advances	25
protein complex	25
potential therapeutic	25
opioid receptor	25
ang ii	25
short peptide	25
binding pocket	25
force field	25
peptide structures	25
synthesized using	25
highly selective	25
tumor cell	25
sequence data	25
intracellular trafficking	25
based therapeutics	25
molecular biology	25
activity towards	25
fl peptide	25
bactericidal activity	25
data categories	25
terminal part	25
bacterial membranes	25
membrane curvature	25
basis function	25
also used	25
protein data	25
adaptive immune	25
antibiotic resistance	25
protein aggregation	25
enzyme activity	25
analyzed using	25
phase transition	24
combinatorial peptide	24
lipid rafts	24
protein expression	24
peptide drugs	24
dimensional structures	24
precursor protein	24
cell responses	24
new generation	24
cytoplasmic membrane	24
click chemistry	24
bovine serum	24
inhibitory effect	24
structural biology	24
nmr spectra	24
therapeutic peptides	24
viral vectors	24
will present	24
clinical use	24
venom peptide	24
factor receptor	24
highly potent	24
protecting group	24
biomedical applications	24
trypsin inhibitor	24
two distinct	24
ms spectra	24
frog amps	24
confi rmed	24
based drug	24
acyl chain	24
new insights	24
cell epitope	24
ic values	24
active sites	24
peptide interactions	24
consensus sequence	24
nuclear localization	24
mass spectrometer	24
viral rna	24
mast cells	23
gel phase	23
virus replication	23
ray diffraction	23
trp residues	23
peptide derivatives	23
cationic peptide	23
like proteins	23
dynamic light	23
skeletal muscle	23
molecular recognition	23
chemical properties	23
carrier protein	23
clinical trial	23
studies showed	23
successfully applied	23
newly synthesized	23
proteomic analysis	23
fatty acid	23
endoplasmic reticulum	23
stapled peptides	23
plasmid dna	23
kcal mole	23
prrp snpf	23
echinoderm prrp	23
acid peptide	23
fibril formation	23
polyethylene glycol	23
specific peptide	23
systemic administration	23
assembled structures	23
binding constants	23
model systems	23
new analogues	23
mediated delivery	23
morpholino oligomers	23
studies revealed	23
structural similarity	23
translational modification	23
ebola virus	23
also showed	23
trimeric coiled	23
polyacrylamide gel	23
cell cultures	23
antibacterial peptides	23
specific peptides	23
fi brils	23
mass spectrum	23
computational design	22
analysis revealed	22
native protein	22
human protein	22
peptide complexes	22
reactive oxygen	22
human genome	22
mass spectrometric	22
peptide conformation	22
assay using	22
tat peptide	22
antisense oligonucleotides	22
gh gl	22
serum samples	22
like receptor	22
human serum	22
peptide molecules	22
coil structure	22
tyrosine kinase	22
three dimensional	22
phosphorylation sites	22
hemolytic activity	22
method using	22
active packaging	22
red blood	22
oxygen species	22
antiproliferative activity	22
antifungal proteins	22
binding studies	22
energy transfer	22
healthy donors	22
capsid protein	22
heavy chain	22
capsid proteins	22
sh domains	22
determined using	22
human brain	22
assembled peptide	22
proline residues	22
direct interaction	22
high levels	22
takes place	22
duchenne muscular	22
two decades	22
fold higher	22
transmembrane ot	22
venom gland	22
recently developed	22
vero cells	22
model peptide	22
fluorescent protein	22
synthesis using	21
new method	21
performance liquid	21
three times	21
exchange chromatography	21
building block	21
splice correction	21
experimental conditions	21
peptide nanostructures	21
recently reported	21
human amps	21
protein targets	21
much less	21
based methods	21
saccharomyces cerevisiae	21
protein surface	21
antibacterial properties	21
free amino	21
common ancestor	21
tat protein	21
electrostatic interaction	21
vaccinia virus	21
important roles	21
virus fusion	21
quantitative analysis	21
blood vessels	21
peptide corresponding	21
immunomodulatory properties	21
disulfide bridge	21
sensing ion	21
therapeutic target	21
bacterial membrane	21
cysteine proteases	21
serum albumin	21
related peptides	21
fmoc tbu	21
shared peptides	21
physiological processes	21
npf prrp	21
antibody response	21
dynamics simulation	21
will also	21
hiv infection	21
proteolytic processing	21
defi ned	21
drug targets	21
snpf prrp	21
peptide may	21
metal ion	21
many different	21
organic solvents	21
hydrophobic content	21
fusion inhibitor	21
investigated using	21
prion protein	21
peptide protein	21
peptide inhibitor	21
peptide cleavage	21
based drugs	21
pro cleavage	21
ii peptides	21
two main	21
peptides also	21
snpf prrpr	21
recombinant human	21
using peptide	21
may represent	20
experimentally determined	20
may play	20
helical structures	20
therapeutic applications	20
two peptide	20
structural motifs	20
syncytial virus	20
acetic acid	20
acid side	20
powerful tool	20
binding constant	20
mdx mice	20
common cold	20
bacterial growth	20
proteolytic degradation	20
ph range	20
chemically synthesized	20
cell division	20
data analysis	20
dna sequences	20
also reported	20
type glycoprotein	20
last decade	20
sheet structures	20
viral genome	20
fi nal	20
expression system	20
artifi cial	20
chemical stability	20
protein tyrosine	20
results indicated	20
human body	20
resistant bacteria	20
peripheral blood	20
inflammatory responses	20
genetically engineered	20
gene encoding	20
remains unclear	20
analysis showed	20
serum amyloid	20
differential scanning	20
i th	20
antibody responses	20
human host	20
dipeptidyl peptidase	20
membrane permeability	20
display library	20
past years	20
peptide therapeutics	20
cellular membranes	20
peptide self	20
virtual screening	20
listeria monocytogenes	20
experimentally validated	20
lipid composition	20
peptide synthesizer	20
domain swapping	20
peptide containing	20
overlapping peptides	20
coupling reaction	20
major role	20
protostome snpf	20
antiviral activities	20
different peptides	20
protein coupled	20
charged amino	20
blood coagulation	20
genes encoding	20
bacillus subtilis	20
terminal sequence	20
respiratory syncytial	20
may provide	20
hydrophobic peptides	19
inhibitory activities	19
neutral ph	19
angiotensin i	19
plasmodium falciparum	19
metal binding	19
protein domains	19
infected patients	19
new peptides	19
different peptide	19
peptide chains	19
releasing hormone	19
oligomerization state	19
type protein	19
cancer therapy	19
molecular dynamic	19
biological fluids	19
cystine knot	19
neutrophil defensins	19
fatty acids	19
clinical studies	19
basic amino	19
previous work	19
whole protein	19
plant peptides	19
like protein	19
creatine kinase	19
gold nanoparticles	19
human alpha	19
potent antimicrobial	19
fpr alx	19
chemical modification	19
based approaches	19
epidermal growth	19
western blot	19
helical peptide	19
several studies	19
allowed us	19
expression systems	19
peptides based	19
hcmv infection	19
catalytic efficiency	19
using nmr	19
peptides show	19
peptide microarray	19
viral load	19
monte carlo	19
epitope prediction	19
shared tryptic	19
quality control	19
proteinase inhibitor	19
virus binding	19
peptides identified	19
coat proteins	19
viral infections	19
fi eld	19
energy minimization	19
previous study	19
large scale	19
chemical modifications	19
hydrophobic length	19
skin secretions	19
mesenchymal stem	19
fold increase	19
antiviral drugs	19
see section	19
structures formed	19
phase method	19
genome sequence	19
formylpeptide receptor	19
last years	19
potent inhibitor	19
salmonella typhimurium	19
leader peptide	19
tumour growth	19
data points	19
quantum dots	19
web server	19
peptides might	19
another study	19
opioid receptors	19
simili swabs	19
peptide fragment	19
cleavage assay	19
binding activity	19
capillary electrophoresis	18
functional protein	18
alzheimer disease	18
spike proteins	18
haemolytic activity	18
terminal peptide	18
single peptide	18
vascular endothelial	18
paneth cell	18
starting point	18
head groups	18
data suggest	18
several peptides	18
virus particles	18
dna fragments	18
type receptor	18
relatively small	18
immune cells	18
structural properties	18
cysteine protease	18
extracellular domain	18
signalling pathways	18
peptide analogs	18
targeted delivery	18
will allow	18
mature peptide	18
protein fragments	18
animal model	18
peptide chemistry	18
rna interference	18
structural proteins	18
peptide peaks	18
proteins containing	18
rich domains	18
cell migration	18
described previously	18
heat shock	18
protein concentration	18
binding affinities	18
analysis using	18
ex vivo	18
amyloid peptide	18
bound peptides	18
cellular functions	18
hepg cells	18
terminal residues	18
affinity binding	18
isoelectric point	18
pdb id	18
sa short	18
binding assays	18
binding free	18
fpr agonists	18
flow cytometry	18
scoring function	18
bacterial pathogens	18
blood glucose	18
hek cells	18
using different	18
peptide family	18
hairpin structure	18
higher affinity	18
four peptides	18
similar results	18
therapeutic strategies	18
low ph	18
binding mode	18
sequence identity	18
interacting proteins	18
inhibit hiv	18
years ago	18
high performance	18
acidic ph	18
lipid transfer	18
results provide	18
also shown	18
new approach	18
peptides will	18
iia peptide	18
human igg	18
carcinogenic cells	18
covalently linked	18
inhibitory concentration	18
hvr epb	18
novel coronavirus	18
fluorescently labeled	18
membrane binding	18
conformational studies	18
food intake	18
lif detection	18
displayed peptide	18
lipid molecules	18
specific antibody	18
directed evolution	18
corresponding peptide	18
peptide bonds	17
untreated cells	17
biophysical properties	17
echinoderm receptors	17
gene silencing	17
authors declare	17
antiviral effects	17
atomic force	17
several different	17
rich peptide	17
different strategies	17
neuronal cells	17
bodily fluids	17
structural data	17
total number	17
protein levels	17
low levels	17
growth factors	17
flight mass	17
conformational properties	17
also present	17
molecular targets	17
flow rate	17
peptide mapping	17
clinical isolates	17
viral protein	17
high efficiency	17
array membrane	17
peptide docking	17
fusion inhibitors	17
protein ligation	17
inhibitory effects	17
force microscopy	17
nucleocapsid protein	17
endothelial growth	17
envelope proteins	17
homology modeling	17
tof mass	17
coil peptide	17
using synthetic	17
peptide database	17
protein target	17
support vector	17
structural motif	17
highly efficient	17
based peptide	17
transition temperature	17
resonance energy	17
mammalian cell	17
negative organisms	17
resistance mechanisms	17
different cell	17
protein misfolding	17
binding affi	17
positive control	17
resistant staphylococcus	17
swab samples	17
two major	17
complex peptide	17
protein production	17
peptides showed	17
west nile	17
triple helix	17
enzymatic degradation	17
also able	17
gel filtration	17
two proteins	17
data obtained	17
fluorescence spectroscopy	17
shed light	17
biological systems	17
hepatocellular carcinoma	17
peptide nanotubes	17
disordered proteins	17
nanomolar range	17
bacterial strains	17
new peptide	17
pharmaceutical industry	17
genetic engineering	17
peptide antibiotic	17
bioinformatics tools	17
sheet structure	17
islet amyloid	17
nmr data	16
amyloid polypeptide	16
high concentration	16
serine proteinases	16
conformational transition	16
sensory neurons	16
peptides across	16
cartridge replacement	16
protein docking	16
new therapeutic	16
vitro studies	16
controlled release	16
statistical analysis	16
profi le	16
fourier transform	16
inflammatory cytokines	16
assembly process	16
salmonella enterica	16
amphipathic peptides	16
acid derivatives	16
frog peptides	16
neuropeptide signalling	16
vector machine	16
phospholipid membranes	16
protein molecules	16
peptide variants	16
snake venoms	16
two classes	16
expression levels	16
resistant strains	16
copy number	16
negative charge	16
reversed phase	16
significant role	16
body fluids	16
function relationship	16
envelope glycoprotein	16
medicinal chemistry	16
signaling pathway	16
antibody binding	16
specific protein	16
carboxyl group	16
cytotoxic activity	16
human blood	16
cholesterol conjugation	16
micromolar range	16
mm sodium	16
myocardial infarction	16
rationally designed	16
lipid mixing	16
antibacterial agents	16
among others	16
well plates	16
molecular cloning	16
outer leaflet	16
natural antimicrobial	16
peptide interaction	16
human antimicrobial	16
new drugs	16
high molecular	16
peptide fusion	16
neutralizing epitope	16
based epitope	16
mediated endocytosis	16
currently available	16
supplemental table	16
specific inhibitors	16
based proteomics	16
studies using	16
membrane interaction	16
sequence information	16
acid analysis	16
helicobacter pylori	16
natural peptides	16
ray structure	16
confocal microscopy	16
virion surface	16
prepared using	16
highly expressed	16
using phage	16
different mechanisms	16
amphiphilic peptides	16
new drug	16
great potential	16
cov spike	16
detailed analysis	16
binding assay	16
viral dna	16
cellular delivery	16
crystalline phase	16
phosphatidic acid	16
cell signaling	16
fmoc chemistry	16
ion exchange	16
steric hindrance	16
novel approach	16
activated protein	16
hepg cell	16
dystrophin expression	16
complex biological	16
develop new	16
growth inhibition	16
aided design	16
inhibit viral	16
data indicate	16
expressed protein	16
stable isotope	16
success rate	16
fluorescence microscopy	16
arctium lappa	16
dendritic cell	16
binding domains	16
conformational flexibility	16
polypeptide chain	16
molecular masses	16
potent anti	16
results demonstrate	16
designed based	16
evaluated using	16
mhc class	16
interfering rna	16
helix formation	15
aromatic amino	15
amyloid fibril	15
lg ml	15
membrane bilayer	15
endocytic pathways	15
primary sequence	15
bacterial infection	15
viral peptide	15
stationary phase	15
cell monolayers	15
antitumor activity	15
proteolytic stability	15
cells expressing	15
peptide epitopes	15
ot helices	15
phosphate buffer	15
activity studies	15
ms detection	15
cysteine proteinase	15
von willebrand	15
seminal plasma	15
scanning electron	15
serine proteinase	15
viral diseases	15
charged peptides	15
frequently used	15
binding partners	15
kinetic parameters	15
inflammatory diseases	15
chemical shift	15
one hand	15
selected peptides	15
also show	15
clinical development	15
fusion mechanism	15
zeta potential	15
rana box	15
antifungal peptides	15
vitro activity	15
structural requirements	15
protein peptide	15
much lower	15
associated coronavirus	15
time pcr	15
peptide nanoparticles	15
deficient mice	15
repeat proteins	15
microwave assisted	15
conformational preferences	15
better understand	15
basic research	15
calculated using	15
surface receptors	15
least three	15
different methods	15
data sets	15
small interfering	15
functional proteins	15
molecular weights	15
high yield	15
sodium channel	15
successfully used	15
binding kinetics	15
different proteins	15
new antimicrobial	15
synthetic vaccines	15
multiple sequence	15
vivo efficacy	15
tryptophan residues	15
goat anti	15
gpcr agonists	15
currently used	15
proteome analysis	15
electron spin	15
direct translocation	15
like function	15
ray scattering	15
membrane interfaces	15
also investigated	15
entry inhibitor	15
effi ciently	15
nile virus	15
high level	15
terminal residue	15
source data	15
reverse transcription	15
free radical	15
limited number	15
peptides present	15
binding peptide	15
alternative splicing	15
amyloid beta	15
four different	15
proteins may	15
structure analysis	15
native state	15
natural sources	15
hydrophobic mismatch	15
biofilm formation	15
promising candidates	15
single molecule	15
hydroxyl group	15
human defensins	15
hiv gp	15
proteolytic activity	15
leucine zipper	15
peptide isolated	15
side reactions	15
great interest	14
coil peptides	14
native structure	14
amphibian skin	14
helical antimicrobial	14
conformational space	14
nmr structure	14
nicotinic acetylcholine	14
confi guration	14
major histocompatibility	14
positive charges	14
ic value	14
mass spectra	14
organic solvent	14
peptide activity	14
based design	14
enveloped virus	14
fusion domain	14
folded proteins	14
gastrointestinal tract	14
peptide dendrimers	14
peptide hormones	14
arabidopsis thaliana	14
time consuming	14
vaccine candidates	14
block oligonucleotides	14
signal sequence	14
new family	14
peptide families	14
tumor targeting	14
host proteins	14
longer peptides	14
different lengths	14
potentially useful	14
acid delivery	14
early stage	14
bacterial cells	14
residual infectivity	14
scrambled peptide	14
virus envelope	14
based method	14
possible role	14
control peptide	14
dna damage	14
necrosis factor	14
interfacial hydrophobicity	14
fluorescence quenching	14
plant amps	14
cell response	14
opioid peptides	14
page gel	14
drug target	14
recently described	14
trichogin ga	14
control group	14
recent reviews	14
using standard	14
aromatic rings	14
catalytic site	14
ad hvr	14
may contribute	14
recently shown	14
protein families	14
good agreement	14
peptide fraction	14
protein substrates	14
also play	14
highly active	14
signalling systems	14
peptide recognition	14
matrix metalloproteinase	14
human erythrocytes	14
adverse effects	14
receptor agonist	14
influenza hemagglutinin	14
shotgun proteomics	14
living organisms	14
structurally similar	14
kinase activity	14
cytokine production	14
activity assay	14
adhesion molecules	14
different protein	14
trifluoroacetic acid	14
terminal end	14
two domains	14
relatively low	14
combinatorial libraries	14
simulated annealing	14
functional domains	14
useful tools	14
ii peptide	14
inclusion bodies	14
cleavage specificity	14
new type	14
web portal	14
delivery vectors	14
alternative approach	14
well established	14
peptide production	14
protein interfaces	14
one way	14
target effects	14
close proximity	14
designed peptides	14
mouse models	14
entry process	14
ligand interactions	14
tau protein	14
plant defensins	14
one peptide	14
also performed	14
many peptides	14
ionization time	14
tumour cells	14
cell type	14
divalent cations	14
various diseases	14
reporter gene	14
significantly increased	14
significantly reduced	14
specific targeting	14
spin labels	14
ga iv	14
diabetes mellitus	14
lysis buffer	14
important factor	14
human breast	14
human formyl	14
binding modes	14
molecular modelling	14
native proteins	14
peptide ligand	14
morpholino oligomer	14
bsp method	14
physiological conditions	14
past decade	14
various biological	14
vesicular stomatitis	14
receptor antagonists	14
early stages	14
hydrophobic side	14
solid state	14
therapeutic index	14
antagonistic activity	14
designed protein	14
receptor subtype	14
human monoclonal	14
hydrophilic residues	14
drug administration	14
calcium mobilization	14
two novel	14
bioactive peptide	14
lung cancer	14
covalently attached	14
antimicrobial protein	14
original peptide	13
burdock root	13
fluid phase	13
organic molecules	13
small number	13
competitive inhibition	13
helical wheel	13
oral administration	13
proteins using	13
precursor proteins	13
functional analysis	13
wide spectrum	13
structural characteristics	13
proteomics data	13
clinical application	13
biological samples	13
cell receptors	13
helical content	13
heterodimeric coiled	13
using high	13
small intestinal	13
neutralizing antibody	13
amp delivery	13
gram positive	13
solution structures	13
acidic residues	13
cystic fibrosis	13
calcium ions	13
domain ii	13
stomatitis virus	13
neutrophil elastase	13
electric field	13
great importance	13
rna polymerase	13
sequence alignments	13
using circular	13
complex mixtures	13
driving force	13
disulphide bonds	13
hydrophobic pocket	13
peptide complex	13
fpr antagonists	13
protein phosphorylation	13
atopic dermatitis	13
computational protein	13
type neuropeptide	13
antioxidant activity	13
proteinase inhibitors	13
scissile bond	13
identified using	13
substrate recognition	13
rich antimicrobial	13
kda protein	13
free peptide	13
novel therapeutic	13
low toxicity	13
two amino	13
affi nities	13
herpes virus	13
high density	13
systemic delivery	13
membrane permeabilization	13
fs capillary	13
peptidase iv	13
labeled peptides	13
cell carcinoma	13
large numbers	13
computational tools	13
cell penetration	13
physical properties	13
food packaging	13
parent peptide	13
bilayer thickness	13
receptor protein	13
water vapor	13
published peptides	13
peak areas	13
inhibited hiv	13
coding sequence	13
role played	13
dna polymerase	13
cell invasion	13
disordered regions	13
particle size	13
enzymatic hydrolysis	13
receptor antagonist	13
positive organisms	13
small size	13
may result	13
therapeutic drugs	13
like particle	13
tertiary structures	13
containing mm	13
carrier proteins	13
cell receptor	13
another approach	13
synthetic vaccine	13
increasing number	13
stranded dna	13
research group	13
therapeutic use	13
cells via	13
viral particles	13
anticancer activity	13
scorpion venoms	13
diseases including	13
protein mixtures	13
receptor activation	13
single chain	13
helix motif	13
relationship studies	13
conserved across	13
formic acid	13
binding specificity	13
transmembrane region	13
promising results	13
antibody fragment	13
ca binding	13
high potential	13
fl ow	13
considerable interest	13
two types	13
hydrophobic surfaces	13
chemotactic activity	13
hcmv gb	13
airway epithelial	13
data show	13
concentration range	13
ot helix	13
higher concentrations	13
transduction pathways	13
research groups	13
uorescence spectroscopy	13
nk cells	13
vast majority	13
experiments showed	13
graduate school	13
rna viruses	13
different stages	13
protein interface	13
protein evolution	13
urgent need	13
barr virus	13
zona pellucida	13
commonly found	13
bacterial species	13
novo designed	13
peptides targeting	13
surface charge	13
million people	13
tropic hiv	13
protein family	13
ischemia reperfusion	13
promising approach	13
provide new	13
willebrand factor	13
ubiquitin ligases	13
inhibition assays	13
tissue engineering	13
protein transduction	13
less effective	13
heptad repeats	13
studies demonstrated	13
physiological ph	13
conserved among	13
binding strength	13
vice versa	13
headgroup region	13
structure activity	13
achieved using	13
tyrosine kinases	13
blood plasma	13
like serine	13
based statistical	13
low concentration	13
small peptide	13
peptide concentrations	13
extensively studied	13
transgenic mice	13
highly effective	13
low micromolar	13
stop codon	13
one another	13
neural network	13
human papillomavirus	13
water interface	13
tissue culture	13
hydrophobicity scale	12
human health	12
type precursors	12
prolyl oligopeptidase	12
derived antimicrobial	12
malaria vaccine	12
particular interest	12
hydrophobic surface	12
nitric oxide	12
based assays	12
subcellular localization	12
bacterial resistance	12
oral bioavailability	12
aromatic ring	12
physiological substrates	12
free energies	12
peptide machines	12
cell biology	12
bronchoalveolar lavage	12
assembling peptides	12
may act	12
ns protease	12
high purity	12
purified using	12
membrane receptors	12
phase i	12
pharmacological properties	12
two new	12
new anti	12
natural peptide	12
transmembrane protein	12
important step	12
tumor necrosis	12
health problem	12
svm models	12
uptake mechanism	12
structural stability	12
results will	12
developed using	12
causative agent	12
well plate	12
protected amino	12
also identified	12
binding region	12
present paper	12
identified peptides	12
coil binding	12
secondary structural	12
binding capacity	12
membrane dehydration	12
cationic host	12
molecular evolution	12
peptides used	12
results revealed	12
high stability	12
histocompatibility complex	12
lipid interactions	12
ms peak	12
comparative analysis	12
targeting peptide	12
sodium phosphate	12
database search	12
human cancer	12
peptides displayed	12
detection system	12
without affecting	12
alpha helices	12
structurally characterized	12
charged lipids	12
covalent attachment	12
experimental results	12
indicator peptides	12
serum stability	12
peptides obtained	12
residues within	12
phosphate groups	12
salt concentration	12
antimicrobial agent	12
reported previously	12
chikv infection	12
type peptide	12
activity spectrum	12
another example	12
may allow	12
assisted solid	12
potential use	12
infectious disease	12
based nanoparticles	12
efficient gene	12
already known	12
negative control	12
mechanical properties	12
aminoisobutyric acid	12
human umbilical	12
plasma samples	12
standard fmoc	12
quantitative structure	12
human fpr	12
vivo delivery	12
resistance genes	12
energy change	12
endothelial cell	12
surface antigen	12
play important	12
defensin genes	12
large amounts	12
essential role	12
predicted epitopes	12
defense peptide	12
current status	12
dna sequence	12
peptide based	12
structural determinants	12
combinatorial chemistry	12
venom compounds	12
inhibition activity	12
aminohexanoic acid	12
efficient delivery	12
binding partner	12
electrospray ionization	12
infrared spectroscopy	12
peptide stapling	12
acidic conditions	12
containing two	12
amphipathic peptide	12
cleavage products	12
well understood	12
short neuropeptide	12
bioactive molecules	12
cys residues	12
respiratory tract	12
forest virus	12
molecule inhibitors	12
methods used	12
amps may	12
multifunctional protein	12
th validation	12
novel class	12
cell apoptosis	12
conserved cysteine	12
cell differentiation	12
consensus clusters	12
vivo study	12
potential drug	12
synthetic strategy	12
five peptides	12
integrin receptor	12
hydrogen peroxide	12
antimicrobial resistance	12
recent work	12
medical applications	12
real time	12
affinity maturation	12
related proteins	12
mycobacterium tuberculosis	12
cytomegalovirus infection	12
immature dendritic	12
two methods	12
using peptides	12
enzyme inhibition	12
containing peptide	12
conformational epitopes	12
mast cell	12
sa aptamer	12
affinity purification	12
well documented	12
drug resistant	12
humoral immune	12
small proteins	12
rgd sequence	12
spectrum activity	12
labeled peptide	12
showed high	12
also applied	12
recognition motif	12
membrane destabilization	12
aqueous media	12
stapled peptide	12
cd binding	12
measured using	12
cleavage assays	12
different concentrations	12
charged side	12
delivery using	12
human disease	12
active peptide	12
inhibitory properties	12
cacybp sip	12
inflammatory cytokine	12
lipid nanoparticles	12
antimicrobial drug	12
venom toxins	12
fmoc solid	12
iii viral	12
i will	12
inflammatory mediators	12
peptide hybrids	12
basic protein	12
glucose level	12
repeat regions	12
krsfiedllfnkv motif	12
vivo experiments	12
studies suggest	12
stress conditions	12
current study	12
antiviral potency	12
transmembrane domains	12
cell lysis	12
highly immunogenic	12
cancer patients	12
iii fusion	12
carpet model	12
novel human	12
highly sensitive	12
functional properties	12
evidence suggests	12
san diego	12
synthetic biology	12
complement system	12
predicted peptides	12
quaternary structure	12
neurological symptoms	11
well characterized	11
soluble proteins	11
significant differences	11
mediated cell	11
study also	11
antifungal protein	11
normal cells	11
rat brain	11
measles virus	11
protein hydrolysate	11
pharmacophore model	11
high sensitivity	11
environmental conditions	11
insulin receptor	11
may induce	11
quantitative proteomics	11
peptides within	11
last two	11
phage particles	11
conjugated peptide	11
anticancer drugs	11
gnrh analogues	11
cardiovascular disease	11
increased resistance	11
drosophila melanogaster	11
electron density	11
transfected cells	11
delivery vehicles	11
glycosylation sites	11
contains two	11
esr spectra	11
taxonomic groups	11
phylogenetic analysis	11
low affinity	11
intracellular targets	11
consensus motif	11
membrane interface	11
bronchial epithelial	11
based vaccines	11
enzyme inhibitors	11
molecular structure	11
ii molecules	11
complex protein	11
fl exible	11
genetically encoded	11
reaction times	11
fpr agonist	11
simili swab	11
muscle cells	11
interacting peptides	11
humoral response	11
antimicrobial packaging	11
hiv fusion	11
ace inhibitors	11
potential role	11
well conserved	11
functional group	11
using molecular	11
biological sciences	11
less potent	11
human salivary	11
low temperatures	11
cellular internalization	11
antiviral peptide	11
high propensity	11
effi cacy	11
will show	11
inhibition assay	11
surface protein	11
activity profiling	11
three classes	11
dynamic simulations	11
amber force	11
inner membrane	11
minimum inhibitory	11
computational approaches	11
also studied	11
dna complexes	11
fl uorinated	11
culture medium	11
data base	11
low doses	11
inclusion list	11
natural product	11
microbial infections	11
peptides exhibited	11
hinge region	11
nmr structures	11
guinea pig	11
three independent	11
breast milk	11
coupling reagent	11
therapeutic intervention	11
effective mobilities	11
coil region	11
consensus sequences	11
binding motifs	11
site directed	11
targeting peptides	11
preliminary results	11
supplementary table	11
antibiotic activity	11
new antibiotics	11
fab library	11
signalling system	11
antiretroviral therapy	11
key residues	11
peptide drug	11
pro residue	11
mrna expression	11
key step	11
dissociation constants	11
template surface	11
carbon nanotubes	11
partially folded	11
antibody recognition	11
cell survival	11
fully understood	11
chemical shifts	11
gram negative	11
myeloid cells	11
spectrum antimicrobial	11
receptor sequences	11
false positive	11
isoelectric focusing	11
proteomics studies	11
time scale	11
adaptive immunity	11
terminal cysteine	11
microwave irradiation	11
peptide aggregates	11
protein microarrays	11
cysteine residue	11
small angle	11
data category	11
acids long	11
peptides consisting	11
ed peptides	11
protein dynamics	11
semliki forest	11
target sites	11
mdx mouse	11
cd receptor	11
spin label	11
type gp	11
receptor ccr	11
rabbit antisera	11
mm ammonium	11
pna conjugates	11
sci proc	11
selective binding	11
results also	11
studies will	11
tetrafl uoroborates	11
wistar rats	11
intestinal epithelial	11
various cell	11
validation model	11
additional file	11
extended conformation	11
intravenous administration	11
ionic interactions	11
sequence motifs	11
dynamic range	11
peptide entry	11
mm edta	11
therapeutic molecules	11
polar residues	11
flexible docking	11
complex model	11
based protein	11
amino terminus	11
peptide showed	11
transfection efficiency	11
pattern recognition	11
cell attachment	11
catalytic triad	11
structural dynamics	11
pseudorabies virus	11
study using	11
single cell	11
antiviral therapeutics	11
binding energy	11
human proteome	11
beta peptide	11
mainly due	11
three main	11
spin resonance	11
results demonstrated	11
pbs containing	11
extensively used	11
highest affinity	11
many types	11
caenorhabditis elegans	11
secondary antibody	11
asymmetric unit	11
dpc micelles	11
lc ms	11
gene family	11
fl exibility	11
peptide mimics	11
green fluorescent	11
envelope glycoproteins	11
built using	11
study revealed	11
multiple copies	11
cationic cpps	11
peptide produced	11
integral membrane	11
sars virus	11
fusion loops	11
fungal cell	11
reaction mixture	11
different amino	11
amyloid fi	11
localization signal	11
cytoplasmic tail	11
cho cells	11
contained within	11
membrane active	11
surface proteins	11
mobile phase	11
conformational epitope	11
ms acquisition	11
peptide contains	11
dimer interface	11
studied using	11
give rise	11
dna gyrase	11
extracellular loop	11
cold allodynia	11
inhibitory peptide	11
frog skin	11
local concentration	11
phage displayed	11
target specificity	11
films incorporated	11
based analysis	11
nasal swab	11
lc gradient	11
model membrane	11
studies indicate	11
amyloid precursor	11
proteins present	11
peptide also	11
corona virus	11
family members	11
electrostatic repulsion	11
ischemic stroke	11
structural elements	11
protein stability	11
high potency	11
ray crystal	11
skin secretion	11
several proteins	11
tyrosine residues	11
previously shown	11
structural differences	11
leading cause	11
long peptides	11
pathogenic microorganisms	11
coupling reactions	11
synthesis method	11
human skin	11
transfer proteins	11
widely distributed	11
muscular atrophy	11
amadori products	11
venom components	11
degradation products	11
transmembrane helices	11
several types	11
positive selection	11
synthetic analogues	11
solution phase	10
pp ab	10
proline residue	10
many amps	10
generated using	10
peptide thioester	10
ms data	10
lung epithelial	10
infl ammatory	10
also synthesized	10
hydrophobic domains	10
cell activation	10
fi ndings	10
targeted gene	10
viral gene	10
folded protein	10
gp binding	10
findings suggest	10
brain tumors	10
food preservation	10
potential antimicrobial	10
orthogonally protected	10
also provides	10
therapeutic agent	10
samples containing	10
peptide ligation	10
protein recognition	10
vitro evolution	10
peptide samples	10
sialic acid	10
peptide exhibited	10
containing amino	10
secondary metabolites	10
uv cd	10
membranotropic sequences	10
cells infected	10
vector machines	10
spinal cord	10
drug molecules	10
buforin ii	10
ace binding	10
functional site	10
platelet activation	10
peptide antimicrobial	10
content mixing	10
endogenous peptide	10
helical bundle	10
peptides bind	10
negative curvature	10
designed peptide	10
translocation across	10
general formula	10
phage particle	10
inhibitory protein	10
antimicrobial proteins	10
viral glycoproteins	10
turn structure	10
significant reduction	10
nmr experiments	10
recently published	10
umbilical vein	10
key roles	10
growing interest	10
three types	10
transform infrared	10
three distinct	10
protein will	10
antiviral agents	10
antiviral therapy	10
peptide amphiphile	10
purified virus	10
ms method	10
metabolic pathways	10
structural similarities	10
electrophoretic mobility	10
mutagenesis studies	10
amphipathic helix	10
lactic acid	10
tumor angiogenesis	10
specific amino	10
interacting partners	10
infarct size	10
amyloid plaques	10
increasing concentrations	10
open reading	10
cleavage activity	10
matrix protein	10
tissue damage	10
amphipathic helical	10
hiv activity	10
spot synthesis	10
carbon atoms	10
new york	10
peptides inhibit	10
significantly higher	10
scrambled peptides	10
may help	10
correlation spectroscopy	10
suffi cient	10
based delivery	10
lipid vesicles	10
inhibitory potency	10
molecular characterization	10
affinity tags	10
disease progression	10
affinity selection	10
recent developments	10
lysine residue	10
modified peptide	10
cyclic rgd	10
therapeutic efficacy	10
phosphorylated peptides	10
food industry	10
biological evaluation	10
lipid peroxidation	10
lower concentrations	10
resin using	10
well studied	10
pancreatic polypeptide	10
phase chemistry	10
drug leads	10
like protease	10
neuronal death	10
physiological functions	10
peptide gene	10
dipolar cycloaddition	10
escape mutations	10
acid substitution	10
biotechnological applications	10
coli strain	10
comparative study	10
extended chain	10
rough surface	10
will lead	10
scale production	10
peptide segments	10
lipid head	10
manually curated	10
point mutation	10
membrane translocation	10
natural substrate	10
protein conformation	10
connectin titin	10
beta defensin	10
peptide antibiotics	10
covalent conjugation	10
protein analysis	10
insect cells	10
ang i	10
dynamics calculations	10
protein fold	10
receptor tyrosine	10
regulatory peptides	10
processes including	10
acquired resistance	10
amersham biosciences	10
blood samples	10
residues located	10
single transmembrane	10
human coronavirus	10
using either	10
xenopus laevis	10
conformationally constrained	10
public health	10
opioid peptide	10
silver nanoparticles	10
may cause	10
culture media	10
amphibian antimicrobial	10
nerve growth	10
significantly improved	10
high specificity	10
will describe	10
experimental evidence	10
low abundance	10
following treatment	10
healthy cells	10
protein association	10
dimerization domain	10
selective pressure	10
rapid identification	10
hiv vaccine	10
cysteine proteinases	10
like activity	10
correlation coefficient	10
free radicals	10
obtained using	10
neutralizing human	10
hydrophobic region	10
viral capsid	10
regulatory proteins	10
times higher	10
phase high	10
single protein	10
obtained results	10
related diseases	10
virus hemagglutinin	10
using solid	10
antiviral properties	10
positive strains	10
aureus strains	10
terminal peptides	10
intravenous injection	10
two groups	10
forming peptide	10
may affect	10
high sequence	10
domain iii	10
gp fusion	10