quadgram

This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

quadgram frequency
in the presence of342
these results suggest that314
in the present study244
as well as the196
on the other hand194
an important role in185
in the absence of184
has been shown to171
the central nervous system154
in the regulation of154
of this study was146
in vitro and in145
vitro and in vivo139
in the pathogenesis of137
this study was to135
play a role in132
as well as in125
play an important role125
have been shown to122
in the development of122
the aim of this121
these results indicate that120
for the treatment of116
results suggest that the113
severe acute respiratory syndrome112
is one of the109
aim of this study107
these data suggest that106
been shown to be102
our results suggest that100
one of the most99
as a result of96
in the context of94
the present study was88
in this study we88
was found to be87
it has been shown87
in the treatment of85
a mouse model of83
for the development of82
the expression of the81
in the number of81
to be involved in79
in a mouse model79
little is known about79
the aim of the79
under the control of78
in the lungs of77
the role of the77
important role in the76
is involved in the75
has been shown that75
be involved in the74
it is important to74
can be used to73
a member of the73
in the central nervous73
of the immune system72
of the present study72
plays an important role70
we have shown that70
for the first time70
had no effect on70
cd and cd t70
to the development of69
a role in the68
an increase in the67
graduate school of medicine66
at the time of66
these findings suggest that66
on the basis of66
we found that the66
of mouse hepatitis virus65
we were able to64
middle east respiratory syndrome63
aim of the present63
of cd t cells63
our results indicate that63
the end of the62
studies have shown that62
for the study of61
were found to be61
c bl j mice61
in the united states61
a significant increase in60
present study was to60
at the end of60
our data suggest that60
in contrast to the57
diagnosis is based on56
by the presence of56
and cd t cells56
the control of the56
in the case of56
our results show that55
in the small intestine55
in the expression of55
is thought to be54
are involved in the54
in addition to the54
investigate the role of53
university school of medicine53
as well as a53
as a model for52
on the surface of52
has been reported to52
university graduate school of52
the presence of a52
a wide range of52
is known about the51
results indicate that the50
presence or absence of50
for the detection of49
of the central nervous49
here we show that49
involved in the regulation49
were observed in the49
may be involved in49
may contribute to the48
we have previously shown48
the presence of the48
is known to be48
a critical role in47
in vivo and in47
a crucial role in47
a large number of46
study was to investigate46
in a variety of46
at the level of46
a major role in46
at the same time46
was observed in the46
it was found that46
east respiratory syndrome coronavirus45
may be associated with45
this work was supported45
in the control of45
acute respiratory distress syndrome45
work was supported by45
investigated the effects of44
the results suggest that44
during the course of44
to investigate the role44
the presence or absence44
acute respiratory syndrome coronavirus44
a wide variety of44
in the spinal cord44
a key role in43
have previously shown that43
these data indicate that43
investigated the effect of43
in a number of43
of reactive oxygen species42
peripheral blood mononuclear cells42
in a model of42
in the formation of42
the regulation of the42
the present study we42
have been used to41
in the induction of41
cells as well as41
the development of the40
was detected in the40
it has been suggested40
c e l l40
the purpose of this40
of cd and cd40
may play a role40
in balb c mice39
increase in the number39
vivo and in vitro39
in rats and mice39
has been reported in39
in the production of39
it has been reported38
was to investigate the38
a decrease in the38
role in the pathogenesis38
has been suggested that38
in order to determine38
the development of a38
for the generation of37
in the bone marrow37
in the liver and37
plays a role in37
t cells in the37
we investigated the effects37
these results demonstrate that37
a better understanding of37
purpose of this study36
there was no significant36
specific cd t cells36
of the immune response36
we have found that35
on the cell surface35
a central role in35
the activity of the35
was associated with a35
we have developed a35
have been reported in35
of this study is35
is considered to be34
for the presence of34
for the induction of34
have shown that the34
is a member of34
we conclude that the34
male and female mice33
that the expression of33
may be due to33
have been associated with33
we have demonstrated that33
in the process of33
the course of the33
we have investigated the33
examined the effects of33
it is possible that33
gene expression in the33
similar to that of33
a pivotal role in33
h n pdm infection33
were found in the33
to be associated with33
in the pathophysiology of33
as a consequence of32
by the use of32
are considered to be32
has been used to32
of the small intestine32
the effects of the32
cd t cells and32
are thought to be32
vascular smooth muscle cells32
in the presence or32
was shown to be32
in the form of32
data suggest that the31
the t cell receptor31
pneumonia virus of mice31
it is known that31
no effect on the31
to play a role31
in c bl mice31
on the expression of31
has been reported that31
it was shown that31
study was to evaluate31
with the development of31
at a concentration of31
t i o n31
be one of the31
examined the effect of31
was used as a31
been reported to be31
these results show that31
balb c mice were31
in the brain and31
and c bl mice30
t h a t30
are known to be30
but not in the30
of severe acute respiratory30
is associated with the30
investigated the role of30
role in the regulation30
innate and adaptive immune30
may be accompanied by30
we have studied the30
the total number of30
this study is to30
on day after inoculation30
are similar to those30
the immune response to30
must be differentiated from29
at different time points29
no significant difference in29
for the production of29
inbred strains of mice29
in the lamina propria29
well as in the29
we also found that29
animal care and use29
investigate the effect of29
a mouse model for29
has also been reported29
in the course of29
the activation of the29
were detected in the29
play a critical role29
cd t cell responses28
the effect of the28
of the t cell28
have been reported to28
as compared to the28
of the oral cavity28
to better understand the28
was found in the28
mhc class i molecules28
balb c and c28
modified vaccinia virus ankara28
b c f mice28
the development of new28
no significant differences in28
might be involved in28
did not affect the28
plays a crucial role28
used as a model28
we investigated the effect28
vg vd t cells28
as well as to28
at the site of27
mouse hepatitis virus infection27
in the brains of27
this is the first27
also been shown to27
the results indicate that27
has been implicated in27
in a murine model27
with the use of27
mice immunized via the27
these findings indicate that27
c bl mice were27
to investigate the effect27
was no significant difference27
the aim of our27
of the inflammatory response27
and the number of27
cd t cells in27
is likely to be26
can be induced by26
play important roles in26
minute virus of mice26
a significant decrease in26
is based on the26
riken brain science institute26
and the development of26
in the activation of26
study was to determine26
of the innate immune26
the time course of26
for the identification of26
t and b cells26
we show that the26
our results demonstrate that26
we examined the effects25
these data demonstrate that25
been implicated in the25
a n t i25
the early phase of25
it was suggested that25
play a crucial role25
play a key role25
with respect to the25
both in vitro and25
and function of the25
is the most common25
on the presence of25
mice were infected with25
to a lesser extent25
the presence of il25
a significant increase of25
the acute phase of25
by the addition of25
we could show that25
the nature of the25
the rat and mouse25
the use of the25
were seen in the25
a transgenic mouse model25
can be found in25
used in this study25
and is associated with24
the protective effect of24
the expression level of24
to the pathogenesis of24
as well as for24
the expression of cd24
of the rat and24
results show that the24
by the administration of24
of a variety of24
in accordance with the24
as one of the24
to play an important24
may play an important24
an animal model of24
we examined the effect24
may be related to24
has been demonstrated in24
by in situ hybridization24
has been associated with24
significant increase in the24
be found in the24
inducible nitric oxide synthase24
a murine model of24
there was a significant24
to test this hypothesis24
was not affected by24
the serum levels of24
c and c bl24
in an attempt to24
w i t h24
vascular endothelial growth factor24
the long pentraxin ptx24
to an increase in24
can be detected in24
in order to investigate24
the severity of the24
was supported by the24
atcf l ko mice23
there were no significant23
not appear to be23
a significant role in23
were approved by the23
cell death clearly fit23
the university of tokyo23
with an increase in23
the surface of the23
better understanding of the23
of the effects of23
the function of the23
types of cell death23
death clearly fit with23
in the oral cavity23
role in the development23
the expression levels of23
and there is no23
morphologic features of cell23
these results suggested that23
of cell death clearly23
a significant reduction in23
is believed to be23
features of cell death23
the formation of the23
similar to that in23
in response to the23
to be the most23
e l l s23
the innate immune system23
the majority of the23
our findings suggest that23
cells were treated with23
in rats treated with23
is responsible for the23
the morphologic features of23
was to evaluate the23
one of the major23
of cell death are23
it is likely that22
be responsible for the22
at least in part22
a single dose of22
aim of the study22
we have recently shown22
findings suggest that the22
and an increase in22
in mice infected with22
increased the number of22
to that of the22
be related to the22
in the ca region22
there was no difference22
be used to detect22
of the most common22
in view of the22
models have been developed22
the mechanism by which22
by a variety of22
play a major role22
between mouse and human22
we investigated the role22
is expressed in the22
of neurons in the22
in the generation of22
can be used as22
the functional role of22
the objective of this22
at the age of22
brain and spinal cord22
immunized via the tc22
with the presence of22
is important for the22
of a number of22
is associated with a22
the size of the22
in order to study22
in order to identify22
compared to wild type22
a result of the21
in the respiratory tract21
known to be involved21
were significantly reduced in21
at a dose of21
cells in the presence21
diarrhea of infant mice21
through the activation of21
the expression of a21
the importance of the21
is required for the21
are found in the21
with regard to the21
the molecular mechanisms of21
a rat model of21
is dependent on the21
is characterized by a21
compared to that of21
the ability of the21
the causative agent of21
be used as a21
the specificity of the21
on the development of21
we are currently investigating21
similar results were obtained21
by an increase in21
of our study was21
involved in the pathogenesis21
we demonstrate that the21
in comparison to the21
cd t cells were21
the results showed that21
when compared to the21
over a period of21
to be expressed in21
an in vitro model21
be the result of21
infection of mice with21
respiratory syndrome coronavirus infection21
can be detected by21
have been developed for21
objective of this study21
for up to days21
aim of our study21
play a pivotal role21
for their ability to20
in the brain of20
we have examined the20
during the development of20
sod g a mice20
is based on a20
have the potential to20
our data show that20
the pathogenesis of the20
porcine apn transgenic mice20
high levels of il20
the molecular mechanisms underlying20
the basis of the20
is due to the20
major role in the20
it has been proposed20
of the study was20
to the activation of20
the use of a20
which is associated with20
could be detected in20
the host immune response20
the expression of il20
mechanisms involved in the20
cells in response to20
our findings indicate that20
the study of the20
and adaptive immune responses20
our understanding of the20
similar to those of20
to a variety of20
the innate immune response20
mice were treated with20
the absence of the20
the course of infection20
our data demonstrate that20
in mouse models of20
the magnitude of the20
the vast majority of20
in the gastrointestinal tract20
present in other organs20
and to a lesser20
the oral cavity pharynx20
in the substantia nigra20
have been identified in20
the results show that20
the influence of the20
plays a major role20
as a model of20
is essential for the20
the lower respiratory tract20
care and use committee20
was also observed in20
is similar to that20
as well as other19
viral and mycoplasmal infections19
has been observed in19
plays a central role19
compared to the control19
does not appear to19
in the cerebral cortex19
used to determine the19
in the hippocampus of19
it is not clear19
to be one of19
in the immune response19
of similar neoplastic cells19
cells is likely present19
in vascular smooth muscle19
has not yet been19
on the role of19
as an animal model19
in the olfactory bulb19
have been observed in19
the mice immunized via19
on the use of19
play a significant role19
have been identified as19
of the most important19
the type of cell19
we have reported that19
in the peripheral blood19
it is necessary to19
the results of the19
of genes involved in19
in a rat model19
the length of the19
the analysis of the19
cd t cells from19
studies have demonstrated that19
likely present in other19
cecal ligation and puncture19
of middle east respiratory19
national institute for physiological19
our data indicate that19
similar neoplastic cells is19
the inhibitory effect of19
infiltration of similar neoplastic19
has the potential to19
type of cell death19
can be used for19
is likely present in19
has not been reported19
here we report that19
neoplastic cells is likely19
is used as a19
in the control group19
is associated with an19
the level of the19
that there is a19
respiratory syncytial virus infection19
as well as by19
in a subset of19
new insights into the19
an animal model for19
the expression pattern of18
in humanized blt mice18
epithelial cells of the18
and the use of18
order to study the18
them separately or a18
is in contrast to18
no requirement to record18
it is well known18
the immune system and18
is supported by the18
combined term is preferred18
plays a critical role18
one of the main18
term is preferred for18
tumor necrosis factor alpha18
of t cell activation18
in the plasma membrane18
by the fact that18
there is no requirement18
and the presence of18
there is no evidence18
to be responsible for18
human hematopoietic stem cells18
is no requirement to18
be due to the18
the mouse in biomedical18
were no significant differences18
at the cell surface18
of the salivary glands18
requirement to record them18
death cannot be determined18
have been implicated in18
of cell death cannot18
record them separately or18
the production of il18
there were no differences18
the role of these18
have been found to18
cannot be determined unequivocally18
systemic inflammatory response syndrome18
in response to a18
to mouse hepatitis virus18
a combined term is18
in animal models of18
separately or a combined18
may be responsible for18
t cell responses to18
used to study the18
considered to be a18
the upper respiratory tract18
h n pdm influenza18
mouse in biomedical research18
in an in vitro18
an important role of18
in comparison with the18
which are known to18
via the tc route18
has been proposed that18
the most commonly used18
is preferred for statistical18
or a combined term18
venezuelan equine encephalitis virus18
for up to weeks18
innate and adaptive immunity18
a high degree of18
cell death cannot be18
is consistent with the18
national institute of neuroscience18
of the gastrointestinal tract18
in line with the18
of tcf l in18
have recently shown that18
to record them separately18
revealed the presence of18
preferred for statistical reasons18
the first time that18
plays a key role18
of the spinal cord18
it is possible to18
in c bl j18
in patients with severe18
the inhibition of the18
s and additional file18
these data show that18
r a n s17
of mhc class i17
japan science and technology17
and b c f17
it has been demonstrated17
we previously reported that17
is based on clinical17
mice infected with the17
were shown to be17
during the first days17
are present and there17
at the periphery of17
that the presence of17
was not observed in17
mice were subjected to17
to the formation of17
for the regulation of17
studied the effects of17
findings indicate that the17
death are present and17
present and there is17
the early stages of17
in the progression of17
and tumor necrosis factor17
metropolitan institute for neuroscience17
in an animal model17
the structure of the17
for the evaluation of17
or more of the17
be detected in the17
as a marker of17
of lymphocytic choriomeningitis virus17
for each of the17
in the majority of17
shown to be a17
which is characterized by17
in the modulation of17
institute for physiological sciences17
the presence of an17
the study was to17
a significant reduction of17
in any of the17
is important to note17
here we demonstrate that17
both types of cell17
is mediated by the17
in the liver of17
associated with an increase17
to the cell surface17
in mice and humans17
critical role in the17
may be found in17
has also been shown17
were significantly increased in17
course of the disease17
of the laboratory mouse17
compared to control mice17
in mice and rats17
t r a n17
the beneficial effects of17
cell death are present17
specific cd and cd17
tokyo metropolitan institute for17
by flow cytometry and17
with the exception of17
at the university of17
was significantly reduced in17
with h n pdm17
of the role of17
been shown that the17
the mesenteric lymph nodes17
the formation of a17
and cd t cell17
porcine epidemic diarrhea virus17
in the brain parenchyma17
over the course of17
it has also been16
rats and b c16
a dose of mg16
have not yet been16
in the salivary glands16
the mrna expression of16
with hematoxylin and eosin16
suggesting a role for16
contribute to the development16
department of anatomy and16
during the acute phase16
the data indicate that16
to be important in16
the expression of these16
involved in the control16
were significantly higher in16
the base of the16
is highly expressed in16
mice are susceptible to16
for the maintenance of16
and there is a16
are responsible for the16
of the nlrp inflammasome16
macrophages and dendritic cells16
was approved by the16
the mechanisms by which16
t c e l16
of the respiratory tract16
a functional receptor for16
in a phase i16
to study the role16
to test the hypothesis16
an important role for16
been shown to play16
it is difficult to16
man and laboratory animals16
our study was to16
did not lead to16
in the stomach of16
in the response to16
compared to those of16
of gd t cells16
of the complement system16
did not show any16
to be due to16
study the role of16
could be involved in16
study we investigated the16
a marked increase in16
reproductive tissue or cell16
the host response to16
of central nervous system16
did not result in16
it is recommended to16
after the onset of16
been found to be16
at the onset of16
may be useful in16
for the expression of16
resulted in a significant16
these observations suggest that16
to the plasma membrane16
in a wide variety16
the liver and spleen16
national institutes of health16
the thickness of the16
dose of mg kg16
of the transcription factor16
in patients with sepsis16
was injected into the16
as well as an16
may be present in16
the mhc class i15
a limited number of15
in vivo imaging of15
in the field of15
in both cell types15
kyushu institute of technology15
may be caused by15
involved in regulation of15
not observed in the15
in the rat brain15
pivotal role in the15
we have previously reported15
of inflammatory bowel disease15
key role in the15
aid for scientific research15
in the gastric mucosa15
or in combination with15
institutional animal care and15
were obtained from the15
a high incidence of15
the absence of a15
was significantly higher in15
to those found in15
study was designed to15
levels were measured by15
significant difference in the15
for a period of15
in the serum of15
which is known to15
hepatitis b virus infection15
appears to be a15
led to a significant15
are members of the15
in the present work15
food and drug administration15
is well known that15
of programmed cell death15
we have identified a15
t cell response to15
have demonstrated that the15
nomenclature and diagnostic criteria15
studied the role of15
focal or focally extensive15
may be seen in15
to that observed in15
in the t cell15
that the number of15
in contrast to other15
in order to examine15
in the study of15
end of the experiment15
of neural stem cells15
a consequence of the15
the levels of il15
the plasma membrane of15
of neutrophils in the15
a potent inhibitor of15
might be due to15
and the expression of15
were used to determine15
a t i o15
the onset of the15
were able to show15
in relation to the15
important to note that15
the systemic inflammatory response15
that the majority of15
in the mice immunized15
is necessary for the15
showed an increase in15
as shown in figure15
the expression of genes15
in the range of15
both cd and cd15
safety and efficacy of15
the cellular and molecular15
was similar to that15
has been described in15
the mucosa of the15
in the mouse and15
it should be noted15
a model for human15
of c bl mice15
to a decrease in15
school of pharmaceutical sciences15
the inhibitory effects of15
which are involved in15
mechanism of action of15
a variety of other15
a variety of different15
is accompanied by a15
be differentiated from other15
are present in the15
alone or in combination15
adult respiratory distress syndrome15
expression of cd and15
production of inflammatory cytokines15
a part of the15
propria or deeper layers15
of cells in the15
the molecular basis of15
after h n pdm15
herpes simplex virus type15
mrna and protein expression15
involved in this process15
infections of laboratory rodents15
to further investigate the15
of mice and rats15
and western blot analysis15
the upper and lower15
play a central role15
the cells of the14
mouse models of human14
positive cells in the14
were measured by elisa14
epizootic diarrhea of infant14
of the nervous system14
was not due to14
does not result in14
absence or presence of14
mice as well as14
determine the effect of14
in the blood and14
understand the role of14
are important in the14
there is evidence that14
results showed that the14
objectives of the study14
as a regulator of14
in the acute phase14
in order to elucidate14
as well as their14
investigate the effects of14
investigated the impact of14
we will discuss the14
have been used in14
was seen in the14
to be related to14
been reported in the14
serum levels of il14
was no difference in14
been used to study14
and a number of14
expression and function of14
by western blot analysis14
we have developed an14
t cell responses in14
there was no correlation14
cultured in the presence14
mouse models have been14
to determine if the14
of cd t cell14
the mechanisms involved in14
cellular and molecular mechanisms14
the periphery of infarction14
is caused by a14
we have analyzed the14
previous studies have shown14
it is suggested that14
performed as previously described14
one or more of14
graduate school of medical14
has been demonstrated that14
it is unclear whether14
has been found in14
effects on biomedical research14
as compared to control14
at weeks of age14
has been studied in14
of the gastric mucosa14
by the expression of14
remains to be determined14
which is involved in14
to the production of14
of respiratory syncytial virus14
were subjected to a14
to the control group14
a number of different14
was identified as a14
in critically ill patients14
in addition to their14
the immune system is14
was used to determine14
we set out to14
mouse hepatitis virus in14
mice as a model14
cells were exposed to14
be considered as a14
mycoplasmal infections of laboratory14
is found in the14
spleen and lymph nodes14
these results suggest the14
lamina propria or deeper14
have been found in14
of the dentate gyrus14
in v i m14
the percentage of cd14
in wild type mice14
the location of the14
was expressed in the14
did not correlate with14
with mouse hepatitis virus14
was performed using the14
aimed to investigate the14
through the use of14
changes in gene expression14
female balb c mice14
we found a significant14
in the early phase14
with special reference to14
and a decrease in14
of the number of14
our aim was to14
and mycoplasmal infections of14
should be noted that14
the absence of any14
to the lack of14
has been proposed to14
to the induction of14
to determine whether the14
significant differences in the14
and duration of the14
to the effects of14
the polymerase chain reaction14
of hla class i14
were not significantly different14
be taken into account14
type i and type14
based on clinical signs14
associated with the development14
proliferation and differentiation of14
it was demonstrated that14
transgenic mouse model of14
in the maintenance of14
involved in the development14
and the lack of14
we propose that the14
test the hypothesis that14
of the squamous epithelium14
was also found to14
might contribute to the14
that can be used14
the purpose of the14
in cd t cells14
the physiological role of14
was not detected in14
the effect of a14
it is concluded that14
for the purpose of14
may serve as a14
no difference in the14
a protective role in14
science and technology agency14
to address this issue14
in the numbers of14
here we investigated the14
by means of a14
lesions of the rat14
of human b cells14
as indicated by the13
virus was detected in13
are likely to be13
is not associated with13
functional receptor for the13
the role of this13
also been reported in13
human cd t cells13
were not able to13
induced by cuff placement13
associated with an increased13
t cell activation and13
in mice immunized with13
to contribute to the13
may be used to13
the primary visual cortex13
the human immune system13
is not well understood13
mice experimentally infected with13
middle cerebral artery occlusion13
in situ hybridization and13
will be used to13
c h hen background13
the tip of the13
a broad spectrum of13
was applied to the13
in the dentate gyrus13
in most of the13
both rats and mice13
data indicate that the13
we hypothesized that the13
a major cause of13
the spinal cord of13
are highly susceptible to13
have also been used13
to be susceptible to13
n rats and b13
ester of carboxylic acid13
to investigate the effects13
compared with the control13
we studied the effects13
are one of the13
central role in the13
significantly higher in the13
in the spleen and13
by the method of13
the mouse cst gene13
have also been shown13
it is not known13
to a lesser degree13
the goal of this13
of this work was13
in male and female13
these results indicated that13
was carried out in13
the development of an13
in the mouse brain13
order to investigate the13
have also been reported13
was significantly lower in13
we focused on the13
was associated with increased13
that the induction of13
can also be used13
similar to those in13
the peripheral nervous system13
of influenza virus infection13
transmissible murine colonic hyperplasia13
containing fetal bovine serum13
models of human disease13
t and b cell13
in the small intestines13
at room temperature for13
does not seem to13
we previously showed that13
due to the lack13
also been reported to13
of the plasma membrane13
the immune system in13
specific t cell responses13
may be induced by13
the relationship between the13
mice were immunized with13
and apoptosis are not13
reduction in the number13
of t cell receptor13
were tested for their13
safety and immunogenicity of13
in their ability to13
of rats and mice13
in mice treated with13
glial cells in the13
an essential role in13
plays a pivotal role13
solution at a concentration13
for at least days13
studied the effect of13
on the immune system13
have been used as13
model for the study13
in the current study13
cytokines such as il13
the development of novel13
cells in the peripheral13
the respiratory tract of13
the lack of a13
f n rats and13
h n influenza virus13
cell surface expression of13
in order to evaluate13
the increased expression of13
was used to measure13
may be difficult to13
of the development of13
the use of this13
of the actin cytoskeleton13
in combination with the13
examined the role of13
mice with zikv inoculation13
to play a key13
which results in the13
rift valley fever virus13
has been found to13
human umbilical vein endothelial13
of the disease in13
were isolated from the13
in health and disease13
western equine encephalitis virus13
can be activated by13
is a requirement for13
from the peripheral blood13
can be isolated from13
a small number of13
under control of the13
in the sera of13
this suggests that the13
in terms of the13
these results suggest a13
fluorescence resonance energy transfer13
the age of weeks13
to the presence of13
the first step in13
an increased number of13
was added to the13
for the formation of13
to determine the effect13
of acute lung injury13
this result suggests that13
the therapeutic potential of13
mice were challenged with13
the lamina propria of13
there is a requirement13
similar to those found13
the context of a13
the possible role of13
graduate school of pharmaceutical13
the mechanism of action13
a high level of13
antigen processing and presentation13
mice are resistant to13
study was undertaken to13
the surface expression of13
the t cell response13
the same dose of13
at days post inoculation13
studies have suggested that13
were also observed in13
bl j mice were13
at the molecular level13
intensity and duration of13
on the type of13
than that of the13
our results showed that13
by a decrease in13
readily distinguishable via routine12
which are phagocytosed by12
not been reported in12
of cytoplasm into surrounding12
a single amino acid12
lymphocytic choriomeningitis virus infection12
cell death with leakage12
has been identified as12
are more susceptible to12
the small intestine of12
used when the type12
has been detected in12
is a functional receptor12
it difficult and impractical12
as a source of12
balb c mice are12
is also used when12
assess the role of12
role in the induction12
with severe acute respiratory12
leading to formation of12
clearly fit with apoptosis12
to play a major12
inflammation such as edema12
occur sequentially and or12
bodies which are phagocytosed12
the regulation of cell12
of the lamina propria12
and expression of the12
elucidate the role of12
it is clear that12
turned out to be12
apoptosis necrosis may be12
by mouse hepatitis virus12
but also in the12
we have previously demonstrated12
in an effort to12
in the drinking water12
and is involved in12
apoptosis are not always12
have been described in12
was not associated with12
are important for the12
this study we investigated12
the quality of the12
by cd t cells12
the care and use12
the potential role of12
is not involved in12
a reported mouse model12
of the effect of12
showed a significant increase12
are phagocytosed by adjacent12
in a decrease in12
of herpes simplex virus12
to differentiate between both12
death with leakage of12
study the effects of12
was significantly higher than12
has been demonstrated to12
a reduction of the12
umbilical vein endothelial cells12
in the core of12
and has been shown12
the number of cells12
this is in contrast12
athymic foxn nu mice12
also used when the12
the lungs of infected12
of the presence of12
for recording apoptosis and12
dependent process leading to12
distinguishable via routine examination12
care and use of12
apoptotic bodies which are12
in order to assess12
might play a role12
into surrounding tissue and12
in the lungs and12
between both during routine12
surrounding tissue and subsequent12
the existence of a12
two processes may occur12
cells of the immune12
mice as compared to12
examine the effects of12
the national institute of12
often makes it difficult12
human respiratory syncytial virus12
has shown that the12
a lethal dose of12
a review of the12
have been used for12
the underlying molecular mechanisms12
special techniques demonstrate apoptosis12
of gaba a receptors12
was determined by the12
sequentially and or simultaneously12
when the type of12
recording apoptosis and necrosis12
of epidermal growth factor12
of balb c mice12
or special techniques demonstrate12
to be able to12
were used as controls12
results demonstrate that the12
be useful in the12
in spite of the12
the brain and spinal12
it is assumed that12
the two processes may12
also found in the12
mrna and protein levels12
is a hallmark of12
we showed that the12
dna double strand breaks12
of the human immune12
in atcf l ko12
as an indicator of12
human peripheral blood lymphocytes12
differences were observed in12
always readily distinguishable via12
member of the genus12
can be blocked by12
for the assessment of12
that the activation of12
different from that of12
significantly increased in the12
in the amount of12
a significant decrease of12
both during routine light12
the c bl j12
energy dependent process leading12
to the muscularis mucosa12
of angiotensin converting enzyme12
mouse hepatitis virus type12
is present in the12
of the pathogenesis of12
requirement for recording apoptosis12
to the site of12
an incubation period of12
are listed in table12
of venezuelan equine encephalitis12
as a model to12
are not always readily12
be used in the12
the chronically stressed mice12
than in the control12
changes in the expression12
necrosis and apoptosis are12
mouse model for the12
in a series of12
of h e stained12
have a role in12
leakage of cytoplasm into12
of apoptotic bodies which12
cytoplasm into surrounding tissue12
morbidity and mortality in12
has proven to be12
the characterization of the12
virus infection in the12
a reduction in the12
or simultaneously depending on12
and in some cases12
cells and b cells12
at any time point12
investigate the impact of12
processes may occur sequentially12
can be associated with12
was reported to be12
we found that in12
and or simultaneously depending12
duration of the noxious12
are also susceptible to12
apoptosis and necrosis separately12
was used for the12
phagocytosed by adjacent cells12
is located in the12
cell and nucleus shrunken12
at the base of12
a requirement for recording12
a high fat diet12
congo hemorrhagic fever virus12
that most of the12
the understanding of the12
tokyo university of agriculture12
this work was to12
during routine light microscopic12
neointimal formation induced by12
formation of apoptotic bodies12
did not differ significantly12
in the mouse model12
the area of the12
in order to understand12
commercially available elisa kits12
not always readily distinguishable12
tissue and subsequent inflammatory12
with leakage of cytoplasm12
are the most common12
impractical to differentiate between12
routine light microscopic examination12
b and t cells12
that is associated with12
of the virus in12
of protein kinase c12
differentiate between both during12
to the regulation of12
and impractical to differentiate12
term apoptosis necrosis may12
into lamina propria or12
and the role of12
considered to be the12
is not clear whether12
was to determine the12
term is also used12
of the intestinal mucosa12
in mouse and human12
assessed by flow cytometry12
and or special techniques12
is characterized by the12
the tc or id12
these studies suggest that12
male wistar rats were12
significantly lower in the12
this often makes it12
virus infection in mice12
necrosis may be used12
with a variety of12
mice were exposed to12
passive cell death with12
of the noxious agent12
infection with h n12
to assess the role12
we examined the role12
cells are able to12
cell types in the12
of science and technology12
in both groups of12
the lamina propria and12
we would like to12
the peripheral blood of12
of the expression of12
do not appear to12
a humanized mouse model12
be expressed in the12
may occur sequentially and12
and the two processes12
lymph nodes and spleen12
the life span of12
i i i i12
the term is also12
to formation of apoptotic12
proliferative lesions of the12
and subsequent inflammatory reaction12
shown to play a12
process leading to formation12
are necessary for the12
young and adult mice12
on intensity and duration12
experimental infection of adult12
makes it difficult and12
on the one hand12
the effects of a12
no significant differences between12
difficult and impractical to12
is the result of12
simultaneously depending on intensity12
depending on intensity and12
and some of them11
up to days after11
dopaminergic neurons in the11
in cb infected mice11
tokyo medical and dental11
japan it has been11
in the cytoplasm of11
but it is not11
de haan et al11
a transient increase in11
may be an important11
one of the two11
with pfu of mva11
to be important for11
study was to identify11
of proinflammatory cytokines and11
the beneficial effect of11
of cytokines and chemokines11
in the lymph nodes11
has been suggested to11
also observed in the11
of laboratory mice and11
in the lung and11
divided into two groups11
has also been described11
significant decrease in the11
which are associated with11
electrical stimulation of the11
viral replication in the11
in response to lps11
mice in comparison to11
cell proliferation and differentiation11
induced in rats by11
implicated in the pathogenesis11
to be mediated by11
is predominantly expressed in11
in the vicinity of11
min at room temperature11
cell proliferation in the11
the united states and11
cells and nuclei swollen11
results in the formation11
polymerase chain reaction analysis11
in bronchoalveolar lavage fluid11
order to determine the11
on the activity of11
is part of the11
and their ability to11
to that of humans11
determine the role of11
mice fed a high11
as part of a11
the utility of the11
a useful tool for11
involved in the formation11
for a variety of11
and balb c mice11
city university graduate school11
the position of the11
treatment of patients with11
associated with a reduction11
evaluation of h e11
the plasma levels of11
are summarized in table11
central nervous system of11
of the p x11
the production of the11
i and type ii11
to be dependent on11
as well as its11
models for the study11
mice were able to11
at each time point11
here we report the11
by h n virus11
in the white matter11
ko mice compared to11
infection of adult mice11
a model for the11
for at least weeks11
even in the absence11
to elucidate the role11
in line with this11
of t and b11
are required for the11
significant differences between the11
t h i s11
we have used a11
in the immune system11
the effects of these11
the results indicated that11
in the percentage of11
on the level of11
balb c mice with11
the molecular mechanisms involved11
new zealand white rabbits11
it is thought that11
may be used in11
hepatitis virus infection in11
as well as on11
not detected in the11
significantly higher levels of11
to the generation of11
crucial role in the11
were used in the11
is currently under investigation11
to those observed in11
stage of the disease11
immune response to infection11
a component of the11
of mice infected with11
in more severe cases11
in the establishment of11
cells were stimulated with11
detected in the lungs11
in the levels of11
tc or id route11
on the production of11
after the administration of11
has been described as11
in contemporary mouse colonies11
cd and cd cells11
lungs of infected mice11
cd t cells with11
as described in the11
of a mouse model11
features of inflammation such11
to the understanding of11
lymphocytic choriomeningitis virus in11
a negative regulator of11
has been isolated from11
have been studied in11
induce the expression of11
is also involved in11
expression of the transgene11
in the adult brain11
in the large intestine11
has yet to be11
pcr and western blot11
the identification of the11
the functionality of the11
c bl mice and11
of c bl j11
with a reduction in11
a great deal of11
is considered to represent11
that the use of11
in the nasal mucosa11
express high levels of11
stages of the disease11
of gene expression in11
hearts and kidneys of11
may be used for11
centers for disease control11
fever with renal syndrome11
cells in the cns11
of a subset of11
with the expression of11
we have observed that11
the modulation of the11
fit with necrotic diagnostic11
been shown to induce11
have not been previously11
are located in the11
is a component of11
blood samples were collected11
of the type i11
in vitro model of11
the blood brain barrier11
the functional significance of11
rats were exposed to11
mouse as a model11
of influenza a virus11
dependent on the presence11
aim of this work11
table s and additional11
are currently investigating the11
in a recent study11
mouse colonies in the11
when compared with the11
t h e r11
we aimed to investigate11
the induction of apoptosis11
by the induction of11
for the care and11
for min at room11
the induction of the11
levels of proinflammatory cytokines11
were identified in the11
the hypothesis that the11
cells were incubated with11
the adaptive immune system11
h n influenza a11
clearly fit with necrotic11
a key regulator of11
of the control group11
compared with that of11
the human and mouse11
cd t cells by11
in a transgenic mouse11
are susceptible to infection11
the in vivo situation11
c bl mice with11
thought to play a11
glial fibrillary acidic protein11
with necrotic diagnostic criteria11
graduate school of science11
significantly reduced in the11
rna virus of the11
as a model system11
the safety and efficacy11
it has been postulated11
has been shown in11
in the early s11
analyzed the effect of11
of tumor necrosis factor11
are believed to be11
to determine the role11
is the causative agent11
in order to test11
regulation of gene expression11
in the number and11
can be achieved by11
in the early stages11
present results suggest that11
implicated in the regulation11
in both humans and11
characterised by the presence11
the production of inflammatory11
in the hippocampal ca11
for the analysis of11
the characteristics of the11
investigated the influence of11
no significant difference between11
stained with hematoxylin and11
the spinal cord and11
mouse proximal apn promoter11
susceptible to infection with11
of inflammation such as11
neuronal activity in the11
increased the expression of11
the impact of the11
housed at their tnt11
could not be detected11
in b c f11
graduate school of life11
of genes associated with11
human peripheral blood mononuclear11
virus replication in the11
innate immune response to11
are associated with the11
expression and activity of10
in epithelial cells of10
caused by mutations in10
in this mouse model10
of nitric oxide synthase10
may be one of10
a positive correlation between10
have the ability to10
for the determination of10
in the level of10
at the cellular level10
be associated with the10
other organs such as10
compared to healthy controls10
and their role in10
is an important mediator10
the lungs of rats10
formation induced by cuff10
these results imply that10
to address this question10
male rats exposed to10
order to understand the10
in experimental models of10
virus infection in a10
the production of tnf10
with the help of10
is associated with increased10
is related to the10
the first time the10
the strength of the10
and tumour necrosis factor10
the production of ifn10
with a number of10
have been identified that10
in the lung tissue10
there is a growing10
than or equal to10
structure and function of10
we investigated the impact10
were not affected by10
be used as an10
to our understanding of10
on cd t cells10
increased expression of the10
was dependent on the10
of microglia in the10
by direct contact with10
that it is a10
we developed a new10
development and function of10
to cd t cells10
is regulated by the10
been shown to produce10
are a family of10
clinical signs of disease10
a wide spectrum of10
both male and female10
mice in which the10
until the end of10
mice were injected with10
all layers of the10
in h e sections10
show for the first10
the molecular mechanism of10
and the level of10
a useful tool to10
were exposed to a10
immune response in the10
eastern equine encephalitis virus10
experiments were performed in10
in the primary visual10
of the virus and10
we found that a10
cells in the bone10
were significantly higher than10
study was supported by10
to a concentration of10
a number of other10
can be induced in10
significantly decreased in the10
c h hen mice10
was carried out by10
with varying degrees of10
to the inhibition of10
been suggested that the10
equine encephalitis virus infection10
we have generated a10
the present results suggest10
of the tca cycle10
weeks after the last10
is not due to10
presence and absence of10
models have been used10
of mice with the10
which may contribute to10
molecular mechanisms involved in10
during the early phase10
cd t cell response10
progenitor cells in the10
lymphocytes and plasma cells10
the context of the10
able to show that10
from peripheral blood of10
has been postulated that10
increased and or abnormal10
the expression and function10
were also able to10
compared with those of10
production of reactive oxygen10
for the isolation of10
infection in immunocompetent mice10
in the draining lymph10
similar to that observed10
we observed that the10
were similar to those10
supported by the dfg10
can be divided into10
klinische pharmakologie und toxikologie10
the morphology of the10
goal of this study10
b and t cell10
in the visual cortex10
we report that the10
in a dose dependent10
its role in the10
in balb c and10
are consistent with a10
via the tc or10
gd t cells in10
cause of death in10
remains to be elucidated10
medical and dental university10
as an inhibitor of10
experiments were carried out10
these two types of10
to this end we10
analyzed the effects of10
cellular and humoral immune10
to the role of10
the capacity of the10
diagnosis is made by10
in t cell activation10
is known about their10
hemorrhagic fever with renal10
and the effect of10
a useful model for10
the pi k akt10
and the induction of10
a grant from the10
for the characterization of10
in the lower respiratory10
experimentelle und klinische pharmakologie10
infiltration of monomorphic population10
infectious and inflammatory diseases10
in suckling mouse brain10
sepsis and septic shock10
known to be a10
been used as a10
pandemic h n influenza10
have been made to10
infected mice at dpi10
mice were housed in10
mice that have been10
determined by flow cytometry10
be present in the10
for the therapy of10
was also detected in10
by the application of10
were infected intranasally with10
be important in the10
japan we examined the10
the role of a10
of inflammatory cytokines and10
resulted in a decrease10
results indicate that a10
of the olfactory epithelium10
in patients with advanced10
responses in mouse models10
has not been elucidated10
the small intestine and10
the molecular basis for10
found to be a10
the medial prefrontal cortex10
chronic obstructive pulmonary disease10
approved by the institutional10
mhc class i and10
in the blood of10
central nervous system and10
and the ability to10
of the mammary gland10
the control of a10
may be mediated by10
with fetal bovine serum10
the interaction of the10
in a previous study10
in cells of the10
in man and laboratory10
the use of an10
mice infected with a10
and the release of10
in the stomach and10
some strains of mice10
the gastric glandular mucosa10
and in situ hybridization10
did not change the10
is not fully understood10
of hepatitis b virus10
the lumen of the10
cells of the central10
an animal model to10
the age of the10
as a receptor for10
is determined by the10
end of the study10
of the nasal cavity10
cd t cell depletion10
the islets of langerhans10
to examine the effects10
in the therapy of10
similar to those observed10
of patients with severe10
that are associated with10
order to determine whether10
the absence or presence10
this effect was not10
phase of the disease10
around the blood vessels10
of the long pentraxin10
a major component of10
in both rats and10
as well as from10
in the culture medium10
in the same way10
on the effects of10
the hearts and kidneys10
accompanied by an increase10
infection is associated with10
it has recently been10
lamina propria of the10
penetration of the mucosa10
h n virus infection10
in addition to its10
these findings suggested that10
model has been developed10
in the absence or10
study was to characterize10
even in the presence10
of the th century10
the development of human10
detected in the brain10
and activation of the10
at different stages of10
in the basal ganglia10
the immune response of10
was followed by a10
are in progress to10
is closely related to10
and mesenteric lymph nodes10
monomorphic population of lymphocytes10
we and others have10
was to compare the10
the important role of10
suggest that activation of10
an increased expression of10
the amount of virus10
n pdm influenza infection10
a point mutation in10
is the presence of10
difference between the two10
are essential for the10
due to differences in10
epithelial cells in the10
have previously demonstrated that10
a potential therapeutic target10
of the adaptive immune10
was used as an10
decrease in the number10
was significantly reduced by10
of the class i10
school of life science10
in the development and10
less is known about10
for the diagnosis of10
of mouse models of10
been shown to have10
expressed in the brain10
will be discussed in10
we are interested in10
amino acid sequence of10
was not significantly different10
in order to develop10
cells but not in10
of inbred mouse strains10
it remains to be10
a decrease of the10
the contribution of the10
class i and ii10
of dengue virus infection10
und klinische pharmakologie und10
the severe acute respiratory10
our findings show that10
disease is caused by10
strains of mice are10
that are responsible for10
also involved in the10
in the guinea pig10
was no correlation between10
an inhibitor of the10
compared to the wild10
the cellular immune response10
was first isolated from10
in the nasal cavity10
with a decrease in10
in the area of10
been described as a10
be associated with a10
of monomorphic population of10
will probably be present10
and or abnormal mitoses10
have not been reported10
male and female rats10
cells in the adult9
infection of rhesus macaques9
along with mature neutrophils9
to study the effect9
in humans and mice9
could be used to9
the core of the9
by the stimulation of9
of the c bl9
colonies in the usa9
on the pathogenesis of9
c bl j and9
most common cause of9
we investigated the expression9
samples were obtained from9
of multiple organ failure9
mrna expression of the9
the adult respiratory distress9
small size of the9
role in the pathophysiology9
acute respiratory syndrome in9
igg and igg a9
a control group was9
the cell surface and9
after the end of9
has an important role9
was able to induce9
after the last immunization9
compared to control cells9
the porcine apn transgene9
the physiological function of9
it is estimated that9
the maintenance of the9
using a panel of9
here we investigated whether9
have previously reported that9
early phase of the9
mice of the same9
in the mouse genome9
we could demonstrate that9
in an in vivo9
been identified as a9
to study the effects9
there may be a9
first step in the9
of vascular smooth muscle9
identified as male reproductive9
regions of the brain9
the administration of the9
which has been shown9
in published maps and9
mimic human inflammatory diseases9
tested the hypothesis that9
in the hippocampus and9
was significantly increased in9
and activator of transcription9
were carried out in9
study was to elucidate9
as a function of9
which is thought to9
excreted in the urine9
to be an important9
in the hearts and9
in this animal model9
neurons and glial cells9
this study aimed to9
exposed to ada for9
characterized by the presence9
been used in the9
regard to jurisdictional claims9
as early as day9
used to assess the9
cells in vitro and9
remains neutral with regard9
differences in the expression9
were used for the9
we show that a9
the mrna levels of9
studying the role of9
on the number of9
regulatory t cells in9
significantly higher than those9
and contributes to the9
reduce the risk of9
of the university of9
were divided into two9
is shown in fig9
to be essential for9
analysis revealed that the9
by intraperitoneal injection of9
we investigated the influence9
to the same extent9
progression of the disease9
nature remains neutral with9
present along with mature9
we analyzed the effect9
neutrophil precursors and or9
has no effect on9
of the lack of9
the p x r9
the results of this9
gene under the control9
associated with the presence9
could be used as9
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the involvement of the9
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and cellular immune responses9
we tested the hypothesis9
important roles in the9
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of human immune system9
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the results of our9
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results of this study9
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mice treated with the9
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the primary motor cortex9
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mice subjected to the9
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the immune system of9
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analyses were performed using9
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a low level of9
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the endothelial cell layer9
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light and electron microscopic9
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as a potential therapeutic9
vg vd t cell9
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rats and mice were9
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the relative contribution of9
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increased levels of il9
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signal transducer and activator9
changes were observed in9
concentration of mm in9
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the slc a gene9
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expression of cd in9
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several lines of evidence9
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immune responses in the9
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role in the immune9
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severe combined immunodeficient mice9
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detection of antibodies to9
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