trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
severe acute respiratory	2897
acute respiratory syndrome	2807
respiratory syndrome coronavirus	2491
middle east respiratory	1251
east respiratory syndrome	1244
in patients with	1136
of the sars	1105
as well as	1063
of the virus	918
patients with covid	909
of severe acute	840
the treatment of	728
the presence of	715
of novel coronavirus	703
the use of	626
the development of	624
the s protein	543
due to the	531
based on the	505
the novel coronavirus	493
a novel coronavirus	493
one of the	452
the spike protein	448
for the treatment	445
of patients with	443
the number of	430
cov cl pro	427
patients with severe	423
detection of sars	410
respiratory distress syndrome	407
in this study	398
acute respiratory distress	394
the risk of	392
infected with sars	390
n a l	388
p r o	388
o u r	387
p r e	387
a l p	387
u r n	387
j o u	387
r o o	387
o o f	387
r n a	387
l p r	387
clinical characteristics of	378
transmission of sars	376
treatment of covid	375
of the disease	366
in addition to	361
in order to	357
of coronavirus disease	353
the role of	352
world health organization	349
cov and mers	342
of middle east	329
according to the	328
a systematic review	324
patients infected with	322
cov and sars	321
patients with sars	319
protein of sars	312
the detection of	307
found to be	307
the severe acute	301
novel coronavirus in	297
structure of the	294
of a novel	294
the united states	289
with severe acute	288
of the s	283
the spread of	282
of sars coronavirus	281
it has been	281
with novel coronavirus	281
the host cell	279
novel coronavirus from	278
associated with the	276
been shown to	275
the absence of	270
of the novel	265
associated with a	265
in the treatment	262
of the covid	259
of the viral	259
critically ill patients	258
hospitalized patients with	254
analysis of the	253
a new coronavirus	250
in the united	248
the possibility of	243
is associated with	243
have been reported	241
syndrome coronavirus infection	235
role in the	233
the onset of	233
there is no	233
the sars coronavirus	233
with severe covid	232
from patients with	232
sars and mers	230
a total of	229
on the other	227
related to the	227
with coronavirus disease	226
clinical features of	225
vero e cells	217
the immune system	216
the other hand	216
in the lungs	214
in the sars	213
novel coronavirus pneumonia	213
dependent rna polymerase	211
of patients infected	211
has been reported	210
such as the	210
the expression of	207
the ace receptor	207
there is a	205
the effect of	205
was used to	204
the s subunit	203
in the absence	203
has been shown	202
viral load in	201
was found to	200
pneumonia in wuhan	200
coronavirus spike protein	200
involved in the	199
the case of	198
of viral rna	198
of the spike	198
a number of	197
the time of	196
the efficacy of	196
this article is	196
to the sars	195
for disease control	191
polymerase chain reaction	190
control and prevention	190
ace and tmprss	189
the severity of	189
the middle east	188
in the case	188
the pathogenesis of	187
the copyright holder	186
all rights reserved	185
the context of	185
compared to the	185
disease control and	184
cd t cells	184
to display the	183
the impact of	182
during the covid	181
at the time	181
a license to	181
the preprint in	181
granted medrxiv a	181
medrxiv a license	181
has granted medrxiv	181
who has granted	181
the respiratory tract	181
display the preprint	181
license to display	181
the production of	180
systematic review and	180
with pneumonia in	180
of hospitalized patients	179
in the context	178
s and s	178
of the coronavirus	177
lower respiratory tract	177
the coronavirus disease	176
need to be	176
in vitro and	175
most of the	175
in saudi arabia	175
of convalescent plasma	175
for the detection	174
some of the	174
can be used	173
the importance of	172
the majority of	172
coronavirus associated with	172
the world health	171
central nervous system	170
for the development	170
to determine the	169
spike protein of	169
copyright holder for	169
holder for this	169
and treatment of	168
were found to	167
the course of	167
a recent study	166
presence of sars	166
of the patients	164
responses to sars	164
as a result	163
has also been	163
responsible for the	163
the emergence of	162
understanding of the	162
patients with coronavirus	162
is the author	161
in the s	161
the author funder	160
onset of symptoms	159
treatment of sars	158
disease in china	157
in terms of	157
spread of the	157
positive for sars	156
the binding of	156
the virus to	156
ill patients with	155
is protected by	155
has not been	155
antibodies against sars	155
protected by copyright	155
to evaluate the	155
article is protected	155
in response to	154
upper respiratory tract	154
to be a	154
for patients with	154
the fact that	154
is important to	154
this version posted	154
receptor binding domain	153
infection with sars	153
the end of	153
be used to	152
crystal structure of	152
cov s protein	152
review and meta	152
it is important	151
to be the	151
detected in the	151
novel coronavirus disease	151
diagnosis of covid	151
intensive care unit	149
the results of	149
a variety of	149
showed that the	148
with a new	148
associated with sars	147
well as the	147
patients with pneumonia	147
high levels of	146
response to sars	145
which was not	145
cases of covid	145
acute lung injury	144
in hong kong	144
part of the	144
in the early	143
features of patients	143
in combination with	143
spread of sars	142
shown to be	142
activation of the	141
caused by sars	141
the most common	141
is responsible for	140
a patient with	140
as a potential	140
by peer review	139
angiotensin converting enzyme	139
certified by peer	139
infected with novel	139
the outbreak of	139
the virus in	138
not certified by	138
the virus and	137
the surface of	137
a review of	137
was not certified	137
in severe covid	136
functional receptor for	136
a pneumonia outbreak	136
the authors declare	136
was detected in	136
structure of sars	136
outbreak associated with	136
t cell responses	135
are associated with	135
of the first	135
as compared to	135
probable bat origin	134
origin of sars	134
the lack of	134
the need for	134
have shown that	133
for treatment of	133
associated with severe	133
for the sars	133
as shown in	132
the identification of	132
human monoclonal antibody	132
the immune response	132
of s protein	131
coronavirus disease in	131
to reduce the	131
new coronavirus of	131
immune response to	131
of the human	131
of probable bat	131
in the lung	131
of cases of	131
coronavirus of probable	131
pneumonia outbreak associated	131
cov spike protein	130
in the human	130
of the most	130
in dromedary camels	130
there are no	130
expression of ace	130
the virus is	129
and clinical characteristics	129
s protein of	129
that can be	128
that the virus	128
to that of	128
caused by the	128
balb c mice	128
on ace and	127
used as a	127
the diagnosis of	127
with acute respiratory	127
included in the	127
the transmission of	127
of the pandemic	126
into host cells	126
transmission of the	126
risk factors for	126
conflict of interest	126
a combination of	126
respiratory disease in	126
the active site	126
the entry of	126
around the world	126
entry depends on	126
and characterization of	126
pneumonia in china	125
a result of	125
a clinically proven	125
depends on ace	125
cell entry depends	124
of critically ill	124
coronavirus in wuhan	124
is blocked by	124
of the immune	124
was performed using	123
in rhesus macaques	123
and tmprss and	123
blocked by a	123
cov infection in	123
influenza a virus	122
and is blocked	122
by a clinically	122
tmprss and is	121
analysis of sars	121
coronavirus infection in	121
clinically proven protease	121
viral rna in	121
coronavirus from patients	121
a role in	121
in the study	120
infection in the	120
that of sars	120
syndrome coronavirus in	120
receptor for sars	120
proven protease inhibitor	120
been reported in	120
in the presence	119
present in the	119
in the respiratory	118
first case of	118
associated with covid	118
an important role	118
development of a	118
a study of	118
the replication of	118
the formation of	117
vitro and in	117
and evolution of	117
be associated with	117
more likely to	117
there was no	117
of the severe	116
the effects of	116
with the sars	116
binding to the	116
insights into the	115
igm and igg	115
characterization of the	115
respiratory syncytial virus	115
identification of a	115
convalescent plasma therapy	114
inhibition of sars	114
of the infection	114
shortness of breath	114
found that the	114
the receptor binding	114
similar to the	114
cov m pro	114
patients in the	113
been reported to	113
the management of	113
have also been	113
to assess the	113
a and b	112
patients with novel	112
the release of	112
the incubation period	112
of severe covid	112
a descriptive study	111
have been shown	111
spike glycoprotein of	111
to the virus	110
antibody responses to	110
it is not	110
likely to be	109
shown in figure	109
was observed in	109
is one of	109
innate immune response	109
receptor recognition by	108
the spike glycoprotein	108
and in vivo	108
after the onset	107
preprint in perpetuity	107
should be considered	107
transmission of covid	107
entry into the	107
domain of the	107
mechanism of action	107
closely related to	107
implications for virus	107
of this study	107
found in the	107
epidemiological and clinical	106
appears to be	106
prevention and control	106
and receptor binding	106
retrospective cohort study	106
important role in	106
response to the	106
the level of	106
were used to	106
replication of sars	106
for severe acute	106
increased risk of	105
on the surface	105
of infected patients	105
at room temperature	105
to have a	105
large number of	105
and pathogenesis of	104
efficacy and safety	104
of the genome	104
of the host	104
the ability to	104
in this review	104
for detection of	104
was associated with	103
to prevent the	103
a series of	103
in the same	103
the activation of	103
cells in the	103
seems to be	103
are needed to	103
is the most	102
virus in the	102
and safety of	102
of sars cov	102
by severe acute	102
to understand the	102
mutations in the	102
consistent with the	102
the viral genome	102
amino acid residues	102
studies of sars	101
of neutralizing antibodies	101
needs to be	101
the duration of	101
cd and cd	101
s protein is	101
in vero e	101
personal protective equipment	101
treatment of severe	101
tested positive for	100
it is possible	100
role of the	100
case of sars	100
play a role	100
li et al	100
and epidemiology of	100
characterization of a	100
the prevalence of	100
studies have shown	100
due to its	100
into the host	100
syndrome coronavirus spike	100
in case of	100
randomized clinical trial	99
activity against sars	99
the ability of	99
a report of	99
in critically ill	99
days after the	99
morbidity and mortality	99
in our study	99
observed in the	98
of the study	98
used in the	98
human immunodeficiency virus	98
in the spike	98
than that of	98
systematic review of	98
a functional receptor	98
reported to be	98
in the first	97
in clinical trials	97
we found that	97
receptor for the	97
the beginning of	97
detection of novel	96
the effectiveness of	96
coronavirus in the	96
for coronavirus disease	96
used for the	96
addition to the	96
contribute to the	96
characteristics of cases	96
the basis of	95
review of the	95
structural basis for	95
in the future	95
close contact with	95
virus origins and	94
with the novel	94
associated with human	94
region of the	94
the virus was	94
obtained from the	94
for virus origins	94
in accordance with	94
epidemiology of novel	94
can also be	94
yet to be	94
diffuse alveolar damage	94
type i interferon	94
are known to	94
binds to the	94
the potential for	94
em structure of	94
origins and receptor	93
the inhibition of	93
have been identified	93
health care workers	93
diagnosis of sars	93
analysis based on	92
be used for	92
respiratory syndrome in	92
different types of	92
a retrospective cohort	92
used to treat	92
a history of	92
in the current	92
evolution of the	92
that of the	92
incubation period of	92
for this preprint	92
with regard to	91
the cytokine storm	91
genomic characterisation and	91
been detected in	91
spike protein and	91
remains to be	91
characterisation and epidemiology	91
of human coronavirus	91
risk of sars	91
by the novel	90
cases of sars	90
that the sars	90
for h at	90
the viral rna	90
of the outbreak	90
the lungs of	89
an increase in	89
inhibition of the	89
human respiratory disease	89
the n protein	89
years of age	89
been associated with	89
nsp and nsp	89
centers for disease	89
binding domain of	89
susceptible to sars	89
approved by the	89
similar to that	89
entry of sars	89
may not be	88
during the sars	88
after symptom onset	88
clinical course and	88
is essential for	88
is based on	88
to the host	88
to treat covid	88
between the two	88
s protein and	87
can lead to	87
in sars patients	87
the potential to	87
could be a	87
an outbreak of	87
of the ace	87
the central nervous	87
a case report	87
the viral load	87
diagnosis and treatment	87
a family cluster	87
for the diagnosis	87
prevention and treatment	87
which is a	86
the origin of	86
and cd t	86
the interaction of	86
new coronavirus associated	86
with human respiratory	86
the host cells	86
manifestations of covid	86
higher risk of	86
end of the	85
cells of the	85
the present study	85
the design of	85
it should be	85
associated with acute	85
no evidence of	85
to be more	85
wang et al	85
wide range of	85
the upper respiratory	85
based on a	85
antiviral activity of	85
expression of the	85
may be a	85
to control the	85
hydroxychloroquine and azithromycin	84
of type i	84
because of the	84
in severe acute	84
coronavirus pneumonia in	84
pathogenesis of sars	84
the discovery of	84
detection of the	84
cytokines and chemokines	84
in contrast to	84
is a functional	84
the human population	84
it is also	84
the cells were	84
was carried out	84
there is an	84
the patient was	84
may also be	84
in the past	84
spread of covid	83
of action of	83
center for disease	83
structural and functional	83
caused by a	83
to detect sars	82
to investigate the	82
suggest that the	82
a wide range	82
are shown in	82
on the basis	82
infected by sars	82
as part of	82
entry into host	82
in the development	82
negative for sars	82
at the same	82
was shown to	82
cases of novel	82
in hospitalized patients	82
in coronavirus disease	82
of the world	82
and outcomes of	82
factors associated with	82
against the sars	81
are involved in	81
inhibitors of sars	81
the analysis of	81
were detected in	81
for novel coronavirus	81
isolated from a	81
may lead to	81
the amount of	81
is consistent with	81
the rbd of	81
the mechanism of	81
be due to	81
in animal models	81
the new coronavirus	81
similar to sars	81
it is a	80
the virus can	80
which can be	80
an overview of	80
in cell culture	80
and middle east	80
igg and igm	80
for min at	80
in a study	80
to the ace	80
the general population	79
suggests that the	79
this study was	79
and it is	79
study of a	79
viral replication and	79
the activity of	79
compared with the	79
each of the	79
in the upper	78
in the prefusion	78
clinical trials are	78
in the brain	78
viral rna was	78
no conflict of	78
and development of	78
and in the	78
antigenicity of the	78
authors declare no	78
of this virus	78
of the manuscript	77
the prefusion conformation	77
for this this	77
this this version	77
have not been	77
patients with mild	77
immune response in	77
and immunogenicity of	77
be used as	77
changes in the	77
evaluation of the	77
remdesivir and chloroquine	77
none of the	77
the viral infection	77
transmission dynamics in	77
cd t cell	77
by the virus	77
to identify the	77
it is made	77
binding of the	77
have been used	76
chloroquine and hydroxychloroquine	76
may contribute to	76
in the viral	76
for the prevention	76
compared to sars	76
structural studies of	76
sars coronavirus infection	76
the university of	76
as a possible	76
is made available	76
the prevention and	76
of a sars	76
with or without	76
made available under	75
shown in table	75
activity of the	75
cluster of pneumonia	75
license it is	75
also known as	75
risk factor for	75
hepatitis c virus	75
in the present	75
in the pathogenesis	75
we did not	75
that there is	75
safety and immunogenicity	75
spike in the	75
of the current	75
effectively inhibit the	75
international license it	75
available under a	75
patients with a	74
orf a and	74
the same time	74
the interaction between	74
a group of	74
as previously described	74
the s domain	74
be detected in	74
immune responses to	74
familial cluster of	74
treatment of patients	74
chen et al	74
be involved in	74
the proportion of	74
the recently emerged	74
t cells in	73
a large number	73
suggesting that the	73
when compared to	73
and antigenicity of	73
early stages of	73
is the first	73
are likely to	73
that have been	73
regions of the	73
isolation and characterization	73
ncov spike in	73
parts of the	73
surface of the	73
sars coronavirus spike	73
the sensitivity of	73
be able to	73
proteins of sars	72
the current pandemic	72
human transmission of	72
immune responses in	72
of ace in	72
thermo fisher scientific	72
would like to	72
a familial cluster	72
suggested that the	72
is likely to	72
the induction of	72
a range of	72
respiratory tract infections	72
are required to	72
at the end	72
of lopinavir ritonavir	72
infection in a	72
sequence of the	72
in these patients	72
neutralizing antibodies against	72
in which the	72
genome sequence of	71
authors declare that	71
novel human coronavirus	71
revealed that the	71
by the sars	71
course of the	71
coronavirus from wuhan	71
emergence of sars	71
severity of the	71
be related to	71
has been observed	71
the innate immune	71
epithelial cells and	71
interaction with the	71
an analysis based	71
the amino acid	71
basis for the	71
airway epithelial cells	71
which may be	71
food and drug	70
infected pneumonia in	70
were observed in	70
contributed to the	70
the availability of	70
infection in vitro	70
in the host	70
inhibit the recently	70
infection by sars	70
considered to be	70
found to have	70
symptoms of covid	70
emerged novel coronavirus	70
mice infected with	70
the lower respiratory	70
appear to be	70
chloroquine effectively inhibit	70
stability of sars	70
study of the	70
recently emerged novel	70
antibodies to sars	69
inhibitors of the	69
increase in the	69
of the n	69
the d g	69
related to sars	69
is possible that	69
due to a	69
been observed in	69
was added to	69
novel coronavirus indicating	69
the main protease	69
was used as	69
and chloroquine effectively	69
mouse hepatitis virus	69
characteristics of coronavirus	69
of the epidemic	69
in the olfactory	69
cov pl pro	69
vaccine against sars	69
traditional chinese medicine	69
ace expression in	69
for the covid	69
in a recent	69
and can be	68
derived from the	68
the setting of	68
preprint this version	68
along with the	68
pneumonia associated with	68
can be detected	68
in line with	68
in complex with	68
this preprint this	68
the causative agent	68
characteristics of hospitalized	68
stage of the	68
antiviral activity against	68
clinical characteristics and	68
due to their	68
during the early	68
the occurrence of	67
coronavirus from a	67
for at least	67
bind to the	67
as compared with	67
preprint the copyright	67
there have been	67
of the new	67
the host immune	67
against the virus	67
a crucial role	67
human monoclonal antibodies	67
of the same	67
recognition by the	67
the crystal structure	67
supported by the	67
replication and pathogenesis	67
infection of sars	67
a cluster of	67
of viral replication	67
a higher risk	67
in southern china	67
of the clinical	67
based on decade	67
any of the	67
is able to	67
case fatality rate	67
in relation to	67
the structure of	67
for middle east	67
sensitivity and specificity	67
depending on the	67
in a patient	67
type i ifn	67
to inhibit the	66
members of the	66
tumor necrosis factor	66
a key role	66
dynamics in wuhan	66
with a high	66
early transmission dynamics	66
of a family	66
in the setting	66
results suggest that	66
case of covid	66
the cardiovascular system	66
such as sars	66
the nucleocapsid protein	66
compared with sars	66
there was a	66
with respect to	66
novel coronavirus associated	66
should not be	66
all of the	66
of pneumonia associated	66
similar to those	65
severity of covid	65
outbreak of sars	65
host cell entry	65
epithelial cells of	65
has been used	65
the s s	65
long structural studies	65
presence of the	65
reported in the	65
the efficacy and	65
during the first	65
known to be	65
cytokine release syndrome	65
human airway epithelial	65
and drug administration	65
rna in the	65
samples were collected	65
in the usa	65
the combination of	65
the olfactory epithelium	65
demonstrated that the	65
is necessary to	65
from a patient	65
can be found	65
the most important	65
results of the	65
of the mers	65
the common cold	65
was supported by	64
has been found	64
evolution of sars	64
reported that the	64
report of cases	64
patients admitted to	64
infected with the	64
type i and	64
active site of	64
identification of the	64
patients with cancer	64
rna was detected	64
the control of	64
the evolution of	64
bound to the	64
genomic characterization of	64
serve as a	64
other respiratory viruses	64
have been developed	64
the olfactory bulb	64
safety and efficacy	64
were able to	64
in comparison to	64
early stage of	64
stages of the	64
is involved in	64
inflammatory cytokines and	64
transmembrane serine protease	64
is mediated by	64
the potential of	64
implications for the	64
onset of illness	63
is supported by	63
located in the	63
to the viral	63
and orf b	63
at the s	63
number of patients	63
the virus from	63
data suggest that	63
for up to	63
and viral load	63
the rate of	63
to be effective	63
mediated by the	63
in some cases	63
multiple sequence alignment	63
were treated with	63
it can be	63
a lack of	63
for the first	63
at least one	63
were obtained from	63
of viral load	63
the early stage	63
neutralizing antibody responses	63
admitted to the	62
the performance of	62
the intensive care	62
host immune response	62
is similar to	62
is required for	62
entry of the	62
was used for	62
isolation of a	62
nature of the	62
of these patients	62
zhou et al	62
detection of viral	62
to develop a	62
as described above	62
structural basis of	62
been found to	62
some of these	62
observational cohort study	62
and control of	62
in the air	62
mesenchymal stem cells	61
case of novel	61
exposure to sars	61
cause of severe	61
a mouse model	61
to severe acute	61
is caused by	61
the existence of	61
were used for	61
patients treated with	61
with convalescent plasma	61
of the receptor	61
sequence of sars	61
of a new	61
a subset of	61
virus infection in	61
data not shown	61
in the covid	61
amino acid sequence	60
the extent of	60
of spike protein	60
the result of	60
from the coronavirus	60
belongs to the	60
to the human	60
better understanding of	60
alveolar epithelial cells	60
outbreak in china	60
is an important	60
of acute respiratory	60
the viral spike	60
open reading frames	60
total number of	60
to detect the	60
antibodies against the	60
sequences of sars	60
the safety and	60
the addition of	60
mild to moderate	60
version posted september	60
the genome of	60
the plasma membrane	60
and that the	60
key role in	60
as in the	60
for the presence	59
could not be	59
in vitro studies	59
infection of human	59
an observational cohort	59
emergency use authorization	59
study showed that	59
results showed that	59
as a treatment	59
zhang et al	59
and management of	59
are based on	59
is known to	59
neutralizing antibodies in	59
symptoms such as	59
with the host	59
disease caused by	59
cell entry and	59
spike protein by	59
in humans and	59
were collected from	59
to study the	59
added to the	59
corona virus disease	59
viral shedding and	59
glycoprotein of sars	59
mechanisms of action	59
in this context	59
beginning of the	59
coronavirus spike proteins	59
yang et al	59
are responsible for	59
of the middle	59
development of vaccines	59
to note that	59
d g mutation	59
of clinical specimens	59
an analysis of	58
outbreak of covid	58
lead to the	58
of the infected	58
the recognition of	58
the first case	58
this is the	58
in another study	58
as described previously	58
isolated from the	58
the percentage of	58
with middle east	58
the virus has	58
levels of il	58
chinese center for	58
a case of	58
the human ace	58
of amino acid	58
for the virus	58
to the development	58
the early stages	58
coronavirus indicating person	58
well as in	58
been used to	58
are essential for	58
the cell surface	58
hospitalized with severe	58
thought to be	58
pp a and	58
was reported in	58
outbreak of severe	58
coronavirus in patients	58
for sars coronavirus	58
the in vitro	58
lead to a	58
leading to the	58
neutralization of sars	57
the international committee	57
an increased risk	57
the relationship between	57
has been detected	57
it was found	57
be a potential	57
were infected with	57
it may be	57
pathogenesis of covid	57
novel coronavirus infection	57
is no evidence	57
that they have	57
s subunit of	57
during the course	57
risk of infection	57
a case series	57
more than of	57
the arabian peninsula	57
indicate that the	57
cov in the	57
acute kidney injury	57
further studies are	57
of the two	57
international committee on	57
many of the	57
and identification of	57
cells infected with	57
be considered as	57
is needed to	57
member of the	57
was able to	57
phase of the	56
new york city	56
control of the	56
mouse model of	56
could be used	56
man with pneumonia	56
clinical trials for	56
virus entry and	56
origin and evolution	56
impact on the	56
no competing interests	56
of viral infection	56
may play a	56
pneumonia in saudi	56
species severe acute	56
together with the	56
has been suggested	56
innate immune responses	56
of human coronaviruses	56
that could be	56
of the rna	56
from a man	56
this work was	56
a global pandemic	56
novel coronavirus outbreak	56
mediated isothermal amplification	56
higher than that	56
by the world	56
a man with	56
t cells were	56
of transmission of	55
a target for	55
wu et al	55
is thought to	55
studies are needed	55
h n influenza	55
origin of the	55
on taxonomy of	55
and risk factors	55
a and pp	55
up to days	55
were positive for	55
it is likely	55
replication in the	55
infectious bronchitis virus	55
human coronavirus nl	55
in this regard	55
seem to be	55
committee on taxonomy	55
that has been	55
the frequency of	55
studies on the	55
seroprevalence of sars	55
of ace and	55
infection in humans	55
and pp ab	55
the s glycoprotein	55
the incidence of	55
of proinflammatory cytokines	55
and igg antibodies	55
led to the	55
from the chinese	55
inhibitor of sars	55
elevated levels of	55
was isolated from	55
of inflammatory cytokines	55
have been described	55
that it is	55
national institute of	54
shown that the	54
was identified as	54
signs and symptoms	54
the process of	54
the generation of	54
its spike protein	54
were found in	54
shown in fig	54
first step in	54
human ace receptor	54
our understanding of	54
respiratory tract of	54
with the virus	54
structures of the	54
out of the	54
in the p	54
aerosol and surface	54
this is a	54
due to sars	54
site of sars	54
is required to	54
the prevention of	54
and severity of	54
the species severe	54
number of cases	54
a trial of	54
prevalence of sars	54
of a patient	54
in the population	54
is essential to	53
patient with covid	53
hr and hr	53
and naming it	53
but not in	53
convalescent plasma for	53
contact with the	53
respiratory tract infection	53
to better understand	53
data indicate that	53
may be the	53
viral loads in	53
confirmed cases of	53
treatment of the	53
hek t cells	53
the cause of	53
is due to	53
of immune response	53
patients hospitalized with	53
the sars outbreak	53
in new york	53
they have no	53
viral entry into	53
coronavirus isolated from	53
rapid spread of	53
data on the	53
on the sars	53
of sars and	53
viruses such as	53
a better understanding	53
the outcome of	53
were associated with	53
naming it sars	53
protein is a	53
identified in the	53
resulted in a	53
the synthesis of	53
of patients who	53
spike protein is	53
insight into the	53
ncov and naming	53
across the globe	52
has shown that	52
this study is	52
the possibility that	52
be found in	52
converting enzyme is	52
t cells and	52
viral load and	52
airborne transmission of	52
potential of sars	52
information on the	52
of the protein	52
to be determined	52
ranging from to	52
play an important	52
in severe cases	52
differences in the	52
has been demonstrated	52
was found that	52
has been described	52
use of convalescent	52
was performed on	52
for design of	52
of ebola virus	52
antibody responses in	52
plasma therapy in	52
and public health	52
open reading frame	52
limit of detection	52
herpes simplex virus	52
characteristics of the	52
causative agent of	52
antibodies in the	52
of the enzyme	52
of spike glycoprotein	52
bronchoalveolar lavage fluid	52
of influenza virus	51
declare that they	51
prior to the	51
host cell membrane	51
was found in	51
are the most	51
domain of sars	51
be noted that	51
the mortality rate	51
innate and adaptive	51
the novel human	51
reduce the risk	51
majority of the	51
use of the	51
the application of	51
also been reported	51
s protein in	51
with lopinavir ritonavir	51
which in turn	51
in this case	51
to be used	51
human coronavirus oc	51
and has been	51
was reported to	51
of the drug	51
features of covid	51
with that of	51
linked immunosorbent assay	51
types of clinical	51
in patients who	51
which has been	51
of the following	51
the lungs and	51
the epidemiology of	51
in patients infected	51
public health emergency	51
in the following	51
the nervous system	51
emerging infectious diseases	51
clinical course of	50
during the pandemic	50
multisystem inflammatory syndrome	50
and efficacy of	50
interaction between the	50
human coronavirus e	50
of hydroxychloroquine in	50
host cell receptor	50
the functional receptor	50
it will be	50
randomized controlled trial	50
enzyme is a	50
length human ace	50
which is the	50
have been found	50
immune response and	50
by a novel	50
infection of the	50
been shown that	50
viral replication in	50
in the elderly	50
a and orf	50
of the nsp	50
this suggests that	50
the viral replication	50
in different types	50
lessons from the	50
cov infection and	50
a cytokine storm	50
and discovery of	50
mechanisms of sars	50
was obtained from	50
in china and	50
samples from the	50
were reported in	50
infection and the	50
of infection and	50
is difficult to	50
of angiotensin converting	50
were shown to	50
the total number	49
characteristics of patients	49
mortality rate of	49
potential role of	49
were identified as	49
x x x	49
were performed using	49
in the receptor	49
potent inhibitor of	49
basis for design	49
nucleic acid detection	49
syndrome associated with	49
important to note	49
depends on the	49
more susceptible to	49
for use in	49
a clinical trial	49
number of infected	49
from the sars	49
management of covid	49
is composed of	49
have been proposed	49
the virus may	49
indicated that the	49
aspects of the	49
and mortality in	49
in the world	49
to the s	49
of the olfactory	49
disease severity in	49
results in the	49
and approved the	49
linked to the	49
before and after	49
not yet been	49
of the international	49
of the total	49
are able to	49
presence of a	49
cases from the	49
is also a	49
identified as the	49
in the literature	49
is believed to	49
outcomes of patients	48
viral spike protein	48
upper and lower	48
the creative commons	48
for vaccine development	48
who did not	48
upper respiratory specimens	48
identification of potential	48
transmission of mers	48
assessment of hospitalized	48
should be noted	48
the family coronaviridae	48
have been observed	48
domain complexed with	48
of infected individuals	48
cytokine storm and	48
virological assessment of	48
has been identified	48
the acute phase	48
belong to the	48
cov infected patients	48
summary of a	48
the rest of	48
the infection of	48
antibody to sars	48
a risk factor	48
like cleavage site	48
is important for	48
of coronavirus spike	48
clinical management of	48
adults hospitalized with	48
accordance with the	48
focused on the	48
patients who have	48
evolution of pathogenic	48
immune response against	48
the viral envelope	48
is a major	48
an in silico	48
fatality rate of	48
novel coronavirus sars	48
of pathogenic coronaviruses	48
high risk of	48
diagnosed with covid	48
at least two	48
tests for sars	48
version of the	48
one or more	48
in vitro antiviral	48
prophylactic and therapeutic	48
information about the	47
to determine if	47
been found in	47
is a potent	47
is shown in	47
spike protein for	47
feline infectious peritonitis	47
taxonomy of viruses	47
bronchial epithelial cells	47
as it is	47
coronavirus infection and	47
may result in	47
the levels of	47
findings suggest that	47
the proximal origin	47
in the last	47
in adults hospitalized	47
in upper respiratory	47
available in the	47
drugs and vaccines	47
for severe covid	47
vesicular stomatitis virus	47
the study was	47
creative commons attribution	47
results of an	47
to improve the	47
expressed in the	47
high level of	47
ribavirin and interferon	47
of clinical trials	47
for the management	47
lopinavir and ritonavir	47
to be an	47
the function of	47
proximal origin of	47
the range of	47
a is the	47
humoral immune response	47
for public health	47
associated with an	47
it would be	47
pregnant women with	47
at higher risk	47
to block the	47
increase the risk	47
global public health	47
all over the	47
the hypothesis that	47
of a vaccine	47
the chinese center	47
the s and	47
used in this	47
evidence of sars	47
risk of covid	47
in the lower	47
coronavirus spike glycoprotein	47
to those of	47
of t cell	46
and other coronaviruses	46
expression in the	46
at the beginning	46
to be associated	46
days after symptom	46
that there are	46
with and without	46
phylogenetic analysis of	46
drug discovery and	46
serum samples from	46
in the community	46
did not show	46
interactions with the	46
has been proposed	46
fusion of the	46
will need to	46
could lead to	46
in a single	46
the respiratory system	46
higher levels of	46
of ace receptor	46
urgent need for	46
showed that sars	46
identified as a	46
of the population	46
the fusion of	46
of children with	46
for the recognition	46
recovered from covid	46
binding to ace	46
that may be	46
cl pro and	46
in human airway	46
acute respiratory disease	46
form of the	46
for the novel	46
of the lung	46
dependent enhancement of	46
of at least	46
transcription polymerase chain	46
cells were washed	46
were included in	46
adaptive immune responses	46
in the middle	46
the sars epidemic	46
outcomes of critically	45
analysis was performed	45
across the world	45
and the other	45
dromedary camels in	45
to the same	45
group of the	45
infected with covid	45
evidence suggests that	45
described in the	45
viral load of	45
binding domain complexed	45
serum samples were	45
animal models of	45
to be infected	45
there are many	45
in china a	45
based on these	45
as of april	45
were used as	45
in infected patients	45
is that the	45
to confirm the	45
is characterized by	45
rate of sars	45
coronavirus nucleocapsid protein	45
previous studies have	45
analysis of a	45
site of the	45
viral infection and	45
summarized in table	45
drugs against sars	45
results of a	45
a decrease in	45
is likely that	45
severe cases of	45
viral nucleic acid	45
in vero cells	45
residues in the	45
use of a	45
could be the	45
cleavage of the	45
state of the	45
is a novel	45
in health care	45
to be highly	45
among patients with	45
and severe acute	45
the association between	45
for diagnosis of	45
risk of death	45
factors for mortality	45
with more than	45
protein data bank	45
and transmission of	45
in the second	45
in the blood	45
neurological manifestations of	45
the distribution of	45
of these drugs	45
followed by a	45
protein and the	45
in peripheral blood	45
of antibodies against	44
for more than	44
associated with increased	44
was identified in	44
these results suggest	44
in the number	44
and prevention of	44
remains neutral with	44
early in the	44
a human monoclonal	44
induced lung injury	44
a randomized clinical	44
cytokine storm in	44
syndrome coronavirus and	44
the antiviral activity	44
acute respiratory infections	44
under a is	44
the origin and	44
immune responses and	44
born to mothers	44
s protein to	44
it is unclear	44
the progression of	44
in this paper	44
on the s	44
published maps and	44
claims in published	44
neutral with regard	44
vertical transmission of	44
by the viral	44
effects on the	44
the genome sequence	44
to jurisdictional claims	44
been reported that	44
and institutional affiliations	44
to the covid	44
over the world	44
safe and effective	44
springer nature remains	44
in balb c	44
therapeutic efficacy of	44
nature remains neutral	44
jurisdictional claims in	44
the most promising	44
of patients in	44
of public health	44
be used in	44
susceptibility to sars	44
test for sars	44
of more than	44
in published maps	44
testing for sars	44
as early as	44
are susceptible to	44
phase i clinical	44
and surface stability	44
characteristics of covid	44
the control group	44
tested negative for	44
regard to jurisdictional	44
is a highly	44
innate immune system	44
not associated with	44
replication of the	44
maps and institutional	44
in sars coronavirus	44
was approved by	44
was defined as	44
time reverse transcription	44
an urgent need	44
development of new	44
distribution of ace	44
other human coronaviruses	44
patients who were	43
of infectious diseases	43
in clinical samples	43
results indicate that	43
number of covid	43
the evaluation of	43
public health measures	43
by means of	43
composition and divergence	43
like to thank	43
conflicts of interest	43
the need to	43
compared to other	43
due to covid	43
of t cells	43
samples from patients	43
surface stability of	43
loss of smell	43
patients with suspected	43
there has been	43
infection in children	43
laboratory diagnosis of	43
and divergence of	43
of infection in	43
republic of china	43
in the field	43
the new york	43
the susceptibility of	43
an update on	43
specimens of infected	43
neutralizing monoclonal antibodies	43
those of the	43
carried out in	43
suggest that sars	43
effect of the	43
are more likely	43
rbd of sars	43
patients with confirmed	43
the sequence of	43
been identified as	43
cytokine storm syndromes	43
national institutes of	43
a potent inhibitor	43
in treatment of	43
from the same	43
in view of	43
acts as a	43
cases and deaths	43
spike protein in	43
the patients with	43
the degree of	43
serine protease tmprss	43
to determine whether	43
are summarized in	43
amino acid substitutions	43
in mice and	43
of hydroxychloroquine and	43
be explained by	43
cellular immune responses	43
a role for	43
considered as a	43
by using the	43
primers and probes	43
at increased risk	43
the regulation of	43
cell entry of	43
human coronavirus infections	43
from the first	42
in our analysis	42
caused by severe	42
storm syndromes and	42
crucial role in	42
and therapeutic options	42
patients suffering from	42
potent neutralization of	42
were negative for	42
the search for	42
in south korea	42
of mers coronavirus	42
the phylogenetic tree	42
peripheral blood mononuclear	42
highly expressed in	42
of ace expression	42
on the use	42
to the spike	42
have to be	42
there were no	42
is an urgent	42
tissue distribution of	42
an inhibitor of	42
and incubated for	42
mutation in the	42
treatment for covid	42
were carried out	42
as described in	42
note springer nature	42
low levels of	42
basis of sars	42
risk of severe	42
of symptom onset	42
followed by the	42
characteristics of and	42
resulting in a	42
high expression of	42
factors such as	42
the study of	42
to test the	42
a member of	42
it was shown	42
the aim of	42
the start of	42
a consequence of	42
targets for the	42
cell responses in	42
converting enzyme in	42
to predict the	42
with an ic	42
as one of	42
clinical features and	42
in this article	42
of influenza a	42
disease severity and	42
have demonstrated that	42
of ace protein	42
a set of	42
of cases from	42
during the outbreak	42
basic reproduction number	42
of the respiratory	42
recent insights into	42
patients with acute	42
the epithelial cells	42
a critical role	42
to mothers with	42
to estimate the	42
the symptoms of	42
the coronaviridae family	42
the complement system	42
exposed to sars	42
consider cytokine storm	42
neutralizing antibodies and	42
therapeutic options for	42
declare no conflict	42
belonging to the	42
the probability of	42
patients with the	41
in the csf	41
antiviral activity and	41
has the potential	41
coronaviruses in the	41
rna polymerase from	41
by the severe	41
transmission potential of	41
into the cell	41
and more than	41
the administration of	41
to the cell	41
the efficiency of	41
incubated for h	41
in the nasal	41
can be considered	41
that patients with	41
in a small	41
host response to	41
the novel sars	41
of and important	41
the first time	41
after onset of	41
coronavirus s protein	41
to interact with	41
were tested for	41
reported to have	41
in this work	41
we believe that	41
humoral and cellular	41
confirmed cases and	41
trial of lopinavir	41
for viral replication	41
and lower respiratory	41
respiratory specimens of	41
and important lessons	41
of the data	41
of viral shedding	41
findings of covid	41
crystal structures of	41
in a large	41
a broad spectrum	41
and infectious diseases	41
to human ace	41
compared to those	41
syndromes and immunosuppression	41
a cohort of	41
response in patients	41
important lessons from	41
research and development	41
of the renin	41
the safety of	41
are similar to	41
be the most	41
vaccines against sars	41
context of the	41
high viral load	41
a basis for	41
binding of sars	41
porcine epidemic diarrhea	41
is expected to	41
performed using the	41
blood mononuclear cells	41
of chest ct	41
the first step	41
emerging human coronavirus	41
institutes of health	41
are in the	41
azithromycin as a	41
the p position	41
as a novel	41
been used for	41
a potential therapeutic	41
their ability to	41
on the viral	41
its ability to	40
outbreak of pneumonia	40
cov n protein	40
and azithromycin as	40
might be a	40
that the s	40
correlates of protection	40
viruses related to	40
is present in	40
considered as the	40
was determined by	40
rna was extracted	40
and duration of	40
of these viruses	40
of confirmed cases	40
with a history	40
hepatitis b virus	40
a potential target	40
and other respiratory	40
of a report	40
disseminated intravascular coagulation	40
have been associated	40
essential for the	40
in close contact	40
cell responses to	40
i and ii	40
protein of the	40
is the main	40
to form a	40
in agreement with	40
of the lungs	40
rest of the	40
genome sequences of	40
a first step	40
patients with middle	40
development of an	40
with the human	40
the first cases	40
we would like	40
may be used	40
protection against sars	40
evidence of the	40
the binding affinity	40
viral shedding in	40
to the hospital	40
by a sars	40
focus on the	40
more severe disease	40
that do not	40
immune system and	40
to play a	40
of the three	40
reactivity with sars	40
and the virus	40
the stability of	40
glycoprotein of the	40
referred to as	40
the state of	40
from an asymptomatic	39
to our knowledge	39
for mortality of	39
has led to	39
difference between the	39
in cancer patients	39
is critical for	39
in light of	39
severe coronavirus disease	39
outbreak of novel	39
plays an important	39
load in upper	39
inhibits the replication	39
of infected cells	39
mortality of adult	39
to the lack	39
are presented in	39
effectiveness of convalescent	39
a novel human	39
protein is the	39
pathological findings of	39
defined as the	39
seen in the	39
the diagnosis and	39
syndrome in children	39
a public health	39
after the first	39
receptor of sars	39
critical role in	39
activity of sars	39
clinical and laboratory	39
and clinical features	39
of an open	39
in the serum	39
the cl pro	39
the virus into	39
were identified in	39
the exception of	39
from severe acute	39
cases have been	39
course and risk	39
been identified in	39
of the cases	39
and those with	39
in human cells	39
the emerging human	39
course and outcomes	39
the reduction of	39
the appearance of	39
increased risk for	39
of the vaccine	39
the rapid spread	39
into emerging coronaviruses	39
other rna viruses	39
most of these	39
positive and negative	39
insights into emerging	39
in the course	39
several studies have	39
and inhibition of	39
results from the	39
infected with mers	39
vitro antiviral activity	39
antibody response to	39
options for the	39
the gastrointestinal tract	39
to increase the	39
of the samples	39
pathogenesis of coronaviruses	39
be required to	39
estimated to be	39
the mechanisms of	39
can be a	39
intrauterine vertical transmission	39
critically ill covid	39
binding site of	39
of the rbd	39
treatment of novel	39
or in combination	39
has resulted in	39
may have a	39
patients who died	39
and t cell	39
with the same	39
and evaluation of	39
adaptive immune response	38
use of corticosteroids	38
as a model	38
responses against sars	38
duration of the	38
studies have demonstrated	38
with severe disease	38
of adult inpatients	38
to sars cov	38
one of these	38
outbreak of coronavirus	38
a single dose	38
manifestations of sars	38
the viral entry	38
led to a	38
coronavirus infection of	38
with the use	38
exposure to the	38
with the s	38
animals to humans	38
pathogenicity of sars	38
there are several	38
in vivo studies	38
in the cell	38
was conducted in	38
and could be	38
is a potential	38
from animals in	38
systemic lupus erythematosus	38
of disease severity	38
b and c	38
the pathophysiology of	38
liu et al	38
increased levels of	38
effects of the	38
protein in the	38
was based on	38
activity in vitro	38
discovery of a	38
effective against sars	38
the interaction with	38
affected by covid	38
ritonavir in adults	38
this may be	38
coronavirus replication in	38
immunogenicity of a	38
adult inpatients with	38
public health and	38
as the most	38
of infection with	38
inflammatory syndrome in	38
is expressed in	38
nucleocapsid protein of	38
the cell membrane	38
the infectivity of	38
have already been	38
interaction of the	38
in the clinical	38
inpatients with covid	38
is not yet	38
rbd of the	38
more than one	38
disease in the	38
which have been	38
the scientific community	38
for viral entry	38
knowledge of the	38
the s gene	38
in the us	38
with the exception	38
induced by sars	38
is effective in	38
approved the final	38
was shown that	38
ace in the	38
proven to be	38
the intermediate host	38
to patients with	38
impact of the	38
the sars cov	38
the current sars	38
by using a	38
and the sars	38
viral and host	38
treatment options for	37
institutional review board	37
in the transmission	37
has not yet	37
has been associated	37
of the major	37
hydrogen bonds with	37
in vitro activity	37
admitted to hospital	37
study on the	37
ebola virus disease	37
studies showed that	37
the concentration of	37
were inoculated with	37
comparison of the	37
initiative on sharing	37
use of remdesivir	37
believed to be	37
model of sars	37
load of sars	37
neurologic manifestations of	37
the inflammatory response	37
the day of	37
but it is	37
of cell entry	37
results in a	37
resulted in the	37
of chloroquine and	37
could be detected	37
the current study	37
high prevalence of	37
to infect humans	37
a retrospective study	37
global initiative on	37
and clinical trials	37
emergence of a	37
models for sars	37
up to of	37
it could be	37
with a higher	37
hydroxychloroquine for the	37
and vaccines for	37
ncov infected patients	37
responses in covid	37
outbreak in wuhan	37
overview of the	37
a median of	37
have the potential	37
between the sars	37
the nature of	37
the type of	37
tested for sars	37
recent studies have	37
chronic obstructive pulmonary	37
were subjected to	37
the gold standard	37
the influence of	37
the centers for	37
and s subunits	37
of rna viruses	37
the disease and	37
supplementary table s	37
viral life cycle	37
of vaccines and	37
such as influenza	37
half of the	37
specific human monoclonal	37
vaccines for covid	37
around the globe	37
do not have	37
specificity of the	37
was confirmed by	37
of the main	37
features of the	37
days after onset	37
at least days	37
four structural proteins	37
potential target for	37
is crucial to	37
on the same	37
and disease severity	37
to be considered	37
is crucial for	37
obstructive pulmonary disease	37
a treatment of	37
at this time	37
as a therapeutic	37
suspected or confirmed	37
is necessary for	37
s protein was	37
a dna vaccine	37
and may be	37
epidemiological characteristics of	37
contact with a	37
viral entry and	37
for the emerging	37
may be due	36
identification of sars	36
cases in the	36
humans and animals	36
and adaptive immune	36
animal model for	36
coronavirus as a	36
case report of	36
to explore the	36
be an effective	36
in infected cells	36
on coronavirus disease	36
indicates that the	36
children with covid	36
higher than the	36
have been detected	36
virus has been	36
this study are	36
respiratory syndrome a	36
severe acute lung	36
with a single	36
be effective against	36
with atypical pneumonia	36
sequences of the	36
recognition by sars	36
work was supported	36
acute respiratory infection	36
in a dose	36
because of its	36
should be taken	36
a recent report	36
leading to a	36
a narrative review	36
viral rna and	36
supported by a	36
susceptibility of ferrets	36
result of the	36
on virus entry	36
the same clade	36
in a community	36
interfere with the	36
in the prevention	36
in spike protein	36
of immune cells	36
and did not	36
against severe acute	36
antiviral effects of	36
a concentration of	36
the loss of	36
evidence for the	36
target for vaccine	36
in more than	36
is related to	36
are included in	36
from symptom onset	36
and analysis of	36
after visiting wuhan	36
the first week	36
bat cov ratg	36
assessment of the	36
effects of chloroquine	36
was performed in	36
studies are required	36
model for sars	36
consists of a	36
a h n	36
the lung and	36
i and type	36
of a covid	36
cq and hcq	36
sars coronavirus from	36
virus to the	36
in the rbd	36
replication in vitro	36
to support the	36
a prospective study	36
of the c	36
declare no competing	36
weeks after the	36
of viruses related	36
onset of the	36
coronavirus envelope protein	36
in the cytoplasm	36
and its implications	36
to the presence	36
and the number	36
have recovered from	36
impact of covid	35
development of covid	35
in china the	35
view of the	35
as a receptor	35
presence of viral	35
huang et al	35
included in this	35
in the infected	35
and characteristics of	35
it is necessary	35
development of the	35
in understanding sars	35
in at least	35
and vaccine development	35
may be more	35
national health commission	35
in the heart	35
nonhuman primate model	35
are necessary to	35
only a few	35
c r i	35
more than million	35
standard of care	35
the understanding of	35
and oropharyngeal swabs	35
in the management	35
patient with atypical	35
distribution of the	35
to the study	35
the date of	35
hospitalized with covid	35
the n k	35
were performed in	35
coronavirus in dromedary	35
animals in southern	35
period of time	35
lopinavir ritonavir in	35
from animals to	35
clinical trial of	35
in our cohort	35
atypical pneumonia after	35
children and adolescents	35
in the range	35
of mutations in	35