bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
respiratory syndrome	4099
acute respiratory	3460
severe acute	2951
novel coronavirus	2610
syndrome coronavirus	2505
coronavirus disease	1643
spike protein	1528
middle east	1309
east respiratory	1258
sars coronavirus	933
immune response	855
viral rna	808
cov infection	778
cl pro	774
clinical trials	773
converting enzyme	726
severe covid	709
respiratory tract	681
amino acid	624
coronavirus infection	618
viral load	617
neutralizing antibodies	602
public health	583
host cell	578
immune responses	555
human coronavirus	528
doc id	514
cord uid	514
epithelial cells	513
respiratory distress	509
binding domain	494
viral replication	492
clinical characteristics	486
cov cl	486
infected patients	480
immune system	479
cytokine storm	473
convalescent plasma	470
viral infection	465
host cells	438
spike glycoprotein	438
systematic review	435
receptor binding	431
clinical trial	429
ace receptor	413
human ace	411
distress syndrome	409
sars cov	399
new coronavirus	397
nucleic acid	396
cell entry	395
united states	390
critically ill	383
coronavirus spike	373
world health	371
rna polymerase	360
lung injury	356
type i	356
virus infection	353
viral entry	352
health organization	351
like protease	349
hospitalized patients	347
antibody responses	347
patients infected	343
animal models	341
main protease	335
viral infections	335
innate immune	335
infectious diseases	335
human coronaviruses	335
clinical features	330
monoclonal antibodies	325
neutralizing antibody	322
respiratory disease	321
health care	316
structural proteins	310
vaccine development	305
ill patients	305
antiviral activity	303
influenza virus	294
saudi arabia	289
intensive care	283
monoclonal antibody	283
lopinavir ritonavir	282
cohort study	278
ace expression	278
inflammatory cytokines	278
nucleocapsid protein	276
nervous system	276
risk factors	272
amino acids	271
human transmission	270
upper respiratory	266
dromedary camels	261
confirmed cases	260
may also	259
hong kong	258
infected cells	255
symptom onset	255
rna viruses	252
disease severity	249
viral shedding	246
membrane fusion	243
coronavirus pneumonia	236
antiviral drugs	231
cancer patients	230
coronavirus infections	228
lower respiratory	227
protease inhibitor	226
dependent rna	225
cov spike	222
disease control	222
cleavage site	221
active site	221
mortality rate	217
virus replication	216
viral genome	214
serum samples	213
gene expression	213
human monoclonal	213
sars patients	211
incubation period	210
associated coronavirus	210
severe disease	209
crystal structure	207
respiratory failure	207
cell responses	202
cell lines	202
inflammatory response	200
respiratory symptoms	198
chain reaction	196
spike proteins	196
rhesus macaques	196
closely related	196
pregnant women	193
polymerase chain	192
viral loads	191
molecular docking	191
healthcare workers	189
ebola virus	188
cell culture	188
recent study	187
virus entry	187
copyright holder	186
rights reserved	186
bat origin	186
clinical course	185
performed using	185
protease inhibitors	185
binding affinity	184
mechanical ventilation	184
peer review	182
granted medrxiv	181
author funder	181
respiratory viruses	180
reverse transcription	178
acute lung	178
igg antibodies	177
drug discovery	177
central nervous	175
coronavirus associated	175
potential therapeutic	174
immune cells	174
antibody response	173
human respiratory	173
phylogenetic analysis	172
mouse model	171
drug repurposing	171
chest ct	171
orf ab	169
receptor ace	168
clinical studies	167
dendritic cells	167
severe cases	167
infectious disease	166
tested positive	165
endothelial cells	164
fatality rate	164
high levels	163
authors declare	162
viral proteins	162
infected individuals	162
severe respiratory	160
structural basis	160
cov clpro	159
lung tissue	158
functional receptor	158
close contact	157
related coronavirus	156
case series	156
pneumonia outbreak	155
version posted	154
serine protease	154
clinical symptoms	154
another study	153
increased risk	153
previous studies	153
care unit	151
infected pneumonia	151
new york	151
pl pro	150
rna virus	149
animal model	148
ace receptors	148
antiviral drug	148
respiratory infections	148
genome sequences	147
plasma therapy	147
stem cells	146
cell membrane	146
dna vaccine	146
viral particles	146
airborne transmission	145
confirmed covid	144
vaccine candidates	143
time rt	143
mers coronavirus	143
rna synthesis	143
first case	142
genome sequence	142
social distancing	142
higher risk	141
transmission dynamics	141
receptor recognition	140
important role	139
angiotensin converting	139
vaccine candidate	139
coronavirus replication	139
cell epitopes	138
vero cells	138
binding site	138
stranded rna	138
heart failure	138
electron microscopy	138
probable bat	137
host immune	137
novel human	137
outbreak associated	136
specific antibodies	136
kcal mol	136
spectrum antiviral	136
randomized clinical	136
dipeptidyl peptidase	135
severe pneumonia	135
bat sars	135
vertical transmission	135
angiotensin ii	134
care workers	134
phase i	134
case report	134
clinical manifestations	134
peripheral blood	133
corona virus	133
controlled trial	133
cell line	132
target cells	131
type ii	131
common cold	129
clinically proven	129
highly conserved	127
entry depends	126
observational study	126
hubei province	126
confirmed sars	125
approved drugs	125
test results	123
human sars	123
sequence alignment	123
innate immunity	122
recent studies	122
protective immunity	122
respiratory syncytial	121
proven protease	121
room temperature	121
descriptive study	120
protective equipment	117
global health	117
person transmission	117
syncytial virus	116
nasopharyngeal swab	116
personal protective	116
case fatality	116
cell surface	116
human airway	115
cov infections	115
emerging coronaviruses	115
significantly higher	114
coronavirus sars	114
clinical samples	113
infection control	113
cell types	113
neurological manifestations	113
structural studies	113
terminal domain	113
therapeutic options	112
open reading	112
rna genome	111
clinical specimens	111
adaptive immune	111
retrospective cohort	111
igg antibody	111
human cells	111
including sars	110
previously described	110
control measures	110
medrxiv preprint	110
respiratory illness	110
human population	109
life cycle	109
alveolar damage	109
side effects	108
also found	108
virtual screening	108
hydrogen bonds	107
virus disease	107
cov replication	107
intermediate hosts	106
mental health	106
family cluster	106
large number	106
inflammatory responses	106
pcr testing	106
one study	106
accessory proteins	105
nasopharyngeal swabs	105
inhibitory activity	105
proinflammatory cytokines	105
respiratory droplets	105
highly pathogenic	105
cov infected	105
therapeutic targets	105
clinical signs	105
envelope protein	105
acid residues	104
control group	104
nasal swabs	104
transgenic mice	104
chadox ncov	103
supplementary table	103
pcr test	103
sequence identity	103
among patients	103
treat covid	103
pp ab	103
human immunodeficiency	103
organ failure	102
host response	102
intermediate host	102
human lung	102
gastrointestinal symptoms	102
cov rna	102
positive patients	101
cell receptor	101
based vaccine	101
risk factor	100
immunodeficiency virus	100
infectious virus	100
currently available	100
asymptomatic patients	99
bat coronavirus	99
thermo fisher	99
diffuse alveolar	99
negative results	99
pdb id	99
oral transmission	99
infected mice	99
em structure	99
positive results	99
diagnostic tests	98
respiratory infection	98
inhibit sars	98
phylogenetic tree	97
recently emerged	97
two different	97
i interferon	97
cytokine release	97
traditional chinese	96
cardiovascular disease	96
airway epithelial	96
antibody titers	96
made available	96
creative commons	96
ace protein	95
angiotensin system	95
virus origins	95
data analysis	94
respiratory specimens	94
viral spike	94
detect sars	94
statistically significant	94
bronchoalveolar lavage	94
analysis based	94
different types	94
blood pressure	93
emergency use	93
high risk	93
cell death	93
hepatitis virus	93
clinical outcomes	93
herd immunity	93
spike receptor	93
international license	92
cov strains	92
multiple organ	92
sample collection	92
nonstructural proteins	92
neutralization assay	91
antiviral agents	91
south korea	91
genomic characterisation	91
genome sequencing	91
therapeutic agents	91
general population	91
cell fusion	91
small molecule	91
endoplasmic reticulum	90
stem cell	90
global pandemic	90
live virus	90
even though	90
chinese medicine	89
also reported	89
specific antibody	89
olfactory bulb	89
wide range	89
randomized controlled	89
also known	89
early stages	89
cell cultures	88
several studies	88
mg kg	88
binding energy	88
multiple sclerosis	88
present study	88
dependent enhancement	88
widely used	88
early stage	87
first step	87
sars outbreak	87
human cases	87
lung pathology	87
weight loss	87
oxidative stress	87
may lead	87
coronavirus outbreak	87
olfactory epithelium	87
molecular dynamics	86
taken together	86
natural products	86
competing interests	86
reverse transcriptase	86
rheumatoid arthritis	85
ncov infection	85
prefusion conformation	85
patients may	85
endothelial cell	85
dry cough	84
mouse models	84
diabetes mellitus	84
avian influenza	84
rna extraction	84
reactive protein	84
effectively inhibit	84
viral transmission	84
severe sars	84
mg ml	84
drug candidates	83
time reverse	83
factors associated	83
health emergency	83
fisher scientific	83
urgent need	82
cov nsp	82
key role	82
mild symptoms	82
study showed	82
clinical data	82
animal species	82
previously reported	82
live attenuated	81
influenza viruses	81
infection may	81
host receptor	81
results showed	81
antibody tests	81
mouse hepatitis	81
dengue virus	81
respiratory virus	81
vaccine design	81
pcr assay	81
isothermal amplification	81
viral pneumonia	80
coronavirus vaccine	80
may contribute	80
high viral	80
informed consent	80
pathogenic coronaviruses	80
results suggest	79
blood donors	79
also observed	79
virus particles	79
phase iii	79
antiviral effects	79
necrosis factor	79
two patients	79
patients admitted	78
case reports	78
coronavirus hku	78
treating covid	78
symptomatic patients	78
based vaccines	78
familial cluster	78
cov pl	78
binding sites	78
nucleic acids	77
also showed	77
retrospective study	77
treatment options	77
crucial role	77
mice infected	77
lung cells	77
older adults	77
southern china	77
alveolar epithelial	77
broad spectrum	77
adverse events	76
days post	76
gastrointestinal tract	76
antibody test	76
small molecules	76
time pcr	76
enzymatic activity	76
tract infections	76
membrane protein	76
cleavage sites	75
plasma membrane	75
negative control	75
causative agent	75
viral protein	75
acute phase	75
recombinant sars	75
cl protease	75
sample size	75
bat coronaviruses	75
described previously	75
serological tests	75
patients treated	75
molecular mechanisms	74
mesenchymal stem	74
adverse effects	74
cells expressing	74
virus infections	74
zika virus	74
igm antibodies	74
current pandemic	74
cq hcq	74
sars virus	74
viral clearance	74
drug development	74
ncov spike	74
commercially available	73
transmembrane serine	73
antibody titres	73
lateral flow	73
positive sars	73
data suggest	72
viral envelope	72
mutation rate	72
contact tracing	72
cardiovascular system	72
blood samples	72
cerebrospinal fluid	72
multiple sequence	71
novel sars	71
protease tmprss	71
myocardial injury	71
computed tomography	71
cell rna	71
better understanding	71
related coronaviruses	71
may play	71
emerged novel	71
pulmonary disease	71
drug administration	71
virus transmission	71
chloroquine effectively	70
effective treatment	70
genomic characterization	70
study group	70
phase ii	70
drug design	70
signaling pathways	70
samples collected	70
genomic rna	70
neurological symptoms	70
commonly used	70
class i	69
may cause	69
clinical presentation	69
ng ml	69
serological assays	69
choroid plexus	69
genetic material	69
i ifn	69
early transmission	69
tissue damage	69
post infection	69
potential role	69
like receptor	69
cytokine production	69
crystal structures	69
coronavirus indicating	69
heptad repeat	68
complete genome	68
expression levels	68
respiratory samples	68
pneumonia associated	68
real time	68
hydrogen bond	68
human angiotensin	68
tumor necrosis	68
emerging infectious	67
cells infected	67
virus type	67
study also	67
available data	67
three times	67
biosafety level	67
like coronavirus	67
acid sequence	67
study clinical	67
bat cov	67
stool samples	67
asymptomatic cases	67
tested negative	66
asymptomatic carriers	66
least one	66
cellular receptor	66
clinical study	66
coronavirus entry	66
small intestine	66
release syndrome	66
sars epidemic	66
protein interaction	66
like particles	66
virus may	66
viral nucleic	66
mild covid	66
tissue distribution	66
patients hospitalized	66
clinical improvement	66
infect humans	66
kidney injury	65
well plates	65
pcr assays	65
therapeutic target	65
preliminary report	65
one health	65
direct contact	65
epithelial cell	65
reading frames	65
coronavirus rna	65
lung damage	65
respiratory viral	65
long structural	65
age group	65
sore throat	65
within days	65
cov genome	65
time points	65
atypical pneumonia	64
infected person	64
infectious bronchitis	64
cov plpro	64
coronavirus main	64
inhibitors targeting	64
positive selection	64
humoral immune	64
complement activation	64
like coronaviruses	64
copies ml	64
vitro studies	64
potential drug	64
linked immunosorbent	64
observational cohort	63
potential treatment	63
data collection	63
icu admission	63
viral titers	63
cytopathic effect	63
medicinal plants	63
lung cancer	63
epi isl	63
inflammatory cytokine	63
clinical management	63
different countries	63
therapeutic strategies	63
study design	63
herpes simplex	63
reproduction number	62
immune evasion	62
pediatric patients	62
species transmission	62
diagnostic testing	62
cov vaccine	62
study reported	62
community transmission	62
respiratory diseases	62
mrna vaccine	62
murine coronavirus	62
china clinical	62
rapid spread	62
human neutralizing	62
antibody detection	62
african green	62
human infection	62
cells via	62
arabian peninsula	62
novel virus	62
fusion protein	62
national institute	62
high mortality	62
nonhuman primates	62
therapeutic efficacy	62
lymph nodes	61
structural protein	61
copies per	61
drug targets	61
reading frame	61
ct scan	61
hospital admission	61
respiratory system	61
differentially expressed	61
total number	61
international committee	61
ill covid	61
statistical analysis	60
human mers	60
neurologic manifestations	60
high affinity	60
use authorization	60
ma virus	60
patients receiving	60
candidate vaccines	60
receptor usage	60
human primates	60
two groups	60
neutralization assays	60
false negative	60
fecal samples	60
disease caused	60
nonhuman primate	60
genetic diversity	60
disease progression	60
posted september	60
like proteases	60
laboratory diagnosis	60
years old	60
guangdong province	60
close contacts	59
serum antibody	59
indicating person	59
lavage fluid	59
acute kidney	59
cov rbd	59
receptor blockers	59
significant difference	59
family coronaviridae	59
convalescent patients	59
emerging human	59
tract infection	59
inflammatory syndrome	59
icu patients	59
recovered patients	59
targeting sars	59
mild disease	59
antibody levels	59
cellular entry	58
human tissues	58
like sars	58
horseshoe bats	58
cov entry	58
current knowledge	58
chloroquine phosphate	58
fusion peptide	58
critical role	58
viral diseases	58
adult patients	58
chinese center	58
study conducted	58
potential drugs	58
antiviral activities	58
antibody testing	58
coronavirus oc	58
coronavirus nl	58
antiviral therapy	58
septic shock	58
highly expressed	57
high level	57
viral genomes	57
mortality rates	57
mediated isothermal	57
seafood market	57
poor prognosis	57
ct values	57
systemic inflammation	57
whole genome	57
highly contagious	57
virus neutralization	57
drug target	57
data indicate	57
bronchial epithelial	57
better understand	57
catalytic activity	57
induced lung	57
molecule inhibitors	57
cellular immune	57
wild animals	57
future studies	57
fusion inhibitors	57
oropharyngeal swabs	57
patients showed	56
laboratory testing	56
cardiac injury	56
type diabetes	56
myocardial infarction	56
high expression	56
positive samples	56
reference sequence	56
coronavirus receptor	56
situation report	56
york city	56
new insights	56
strand rna	56
significantly lower	56
might also	56
neutralizing monoclonal	56
severely ill	56
species severe	56
coronavirus nucleocapsid	56
elevated levels	56
palm civets	56
whether sars	56
reported cases	56
conformational changes	56
day post	56
immunosorbent assay	56
molecular biology	55
relatively low	55
may result	55
neurological complications	55
bronchitis virus	55
proteolytic cleavage	55
human covs	55
analysis showed	55
positive control	55
supportive care	55
ace inhibitors	55
coronavirus isolated	55
interim guidance	55
secondary structure	55
wastewater treatment	55
antiviral effect	55
respiratory pathogens	55
length human	55
type iii	55
potent inhibitor	55
free energy	54
inhibits sars	54
virus spread	54
low levels	54
higher levels	54
bovine serum	54
prospective study	54
pathological findings	54
recombinant protein	54
interstitial pneumonia	54
cell response	54
rapid detection	54
infected animals	54
cov outbreak	54
will need	54
asymptomatic individuals	54
alveolar macrophages	54
findings suggest	54
sequence analysis	54
humoral response	53
like cleavage	53
pathogenic coronavirus	53
dna vaccines	53
viral fusion	53
dromedary camel	53
potential risk	53
sectional study	53
reverse genetics	53
two viruses	53
viral respiratory	53
enveloped viruses	53
host range	53
genomic sequences	53
will help	53
following sars	53
molecular weight	53
brain barrier	53
face masks	53
protein kinase	53
dependent manner	53
neutralizing activity	53
positive cases	53
probable sars	53
compassionate use	53
syndrome associated	53
simplex virus	53
respiratory coronavirus	53
health authorities	53
based assay	53
transmissible gastroenteritis	53
antiviral compounds	53
severe illness	53
family members	52
oxygen saturation	52
viral pathogenesis	52
asymptomatic sars	52
national health	52
clinical practice	52
complement system	52
inactivated vaccine	52
malayan pangolins	52
scientific community	52
pcr tests	52
nosocomial transmission	52
signaling pathway	52
lung tissues	52
generated using	52
prevent sars	52
one patient	52
specific igg	52
may provide	52
biorxiv doi	52
potential inhibitors	51
coronavirus papain	51
rbd protein	51
throat wash	51
kawasaki disease	51
applied biosystems	51
replication cycle	51
determine whether	51
viral antigen	51
results indicate	51
lung disease	51
rna replication	51
mononuclear cells	51
critical care	51
protein interactions	51
related viruses	51
hr domain	51
hand hygiene	51
multisystem inflammatory	51
common symptoms	51
many countries	51
potential target	51
case study	51
first cases	50
influenza vaccine	50
studies showed	50
remains unclear	50
clinical outcome	50
throughput screening	50
current sars	50
acid detection	50
disease map	50
interferon beta	50
sense rna	50
neutralising antibodies	50
hace mice	50
vitro antiviral	50
angiotensinconverting enzyme	50
substrate binding	50
nasal swab	50
understanding sars	50
million people	50
diagnostic test	50
cysteine protease	50
supplementary material	50
viral spread	50
fda approved	50
adapted sars	50
cov isolates	50
social isolation	49
phase clinical	49
human cell	49
coronaviridae family	49
statistical significance	49
adults hospitalized	49
pulmonary embolism	49
sequence similarity	49
convalescent sera	49
severe symptoms	49
patients without	49
medical records	49
white blood	49
protein data	49
vaccinia virus	49
ongoing clinical	49
organ dysfunction	49
current study	49
cov patients	49
still unclear	48
cov may	48
bcg vaccination	48
treatment strategies	48
virological assessment	48
entry receptor	48
western blot	48
coronavirus genome	48
specific human	48
suspected sars	48
vesicular stomatitis	48
feline infectious	48
new virus	48
test result	48
wuhan city	48
early detection	48
domain complexed	48
united kingdom	48
commons attribution	48
potential vaccine	48
previous study	48
transcription polymerase	48
least two	48
transmission potential	48
ocular surface	48
rhesus macaque	48
palm civet	47
clinical findings	47
throat swabs	47
inactivated sars	47
angiotensin receptor	47
inhibiting sars	47
expressing cells	47
viral proteases	47
cause severe	47
emergency department	47
global public	47
fusion inhibitor	47
like receptors	47
gold standard	47
results obtained	47
proximal origin	47
organ damage	47
may help	47
stomatitis virus	47
acid substitutions	47
anal swabs	47
nsp nsp	47
antibodies targeting	47
infectious peritonitis	47
buffered saline	47
infection rates	47
protein expression	47
pandemic influenza	47
also used	47
per day	47
transmission routes	46
ic values	46
single dose	46
recent advances	46
human igg	46
infected cell	46
data bank	46
hospitalized covid	46
evidence suggests	46
virus vaccine	46
inhibitory effect	46
infect dis	46
cov virus	46
open access	46
ace binding	46
time course	46
essential oils	46
clinical efficacy	46
target cell	46
glass opacities	46
preventive measures	46
available online	46
per well	46
among others	46
virus titers	46
intravenous immunoglobulin	46
protein binding	46
disease course	46
highly specific	46
furin cleavage	46
potent neutralizing	46
virus shedding	46
close proximity	46
mild respiratory	46
determined using	46
health measures	46
highly sensitive	46
adaptive immunity	46
disease pathogenesis	45
sars cases	45
cell activation	45
predictive models	45
infection prevention	45
interspecies transmission	45
human health	45
first reported	45
severe patients	45
drug repositioning	45
host factors	45
will also	45
coronavirus envelope	45
higher affinity	45
current evidence	45
surface stability	45
human host	45
much higher	45
protective efficacy	45
urgently needed	45
van der	45
current status	45
tissue culture	45
spanish flu	45
primate model	45
neutralization test	45
protein sequence	45
heart disease	45
abdominal pain	45
genome replication	45
rna sequencing	45
three different	45
i clinical	45
phylogenetic trees	45
median age	45
pathogenic human	45
patients suffering	45
sequence homology	45
patients will	45
machine learning	45
springer nature	44
mildly symptomatic	44
institutional affiliations	44
environmental factors	44
infected people	44
positive rate	44
express ace	44
high sensitivity	44
published maps	44
using human	44
ic value	44
may occur	44
study found	44
remains neutral	44
national institutes	44
culture supernatants	44
coronavirus nsp	44
cell infection	44
jurisdictional claims	44
basic reproduction	44
significantly reduced	44
severe coronavirus	44
coronavirus vaccines	44
nature remains	44
relative humidity	44
serum antibodies	44
less severe	44
ct findings	44
health commission	44
ravulizumab bsc	44
angiotensin i	44
systemic inflammatory	44
potential targets	44
pcr results	44
main proteinase	44
transmembrane protease	43
narrative review	43
cell type	43
breast milk	43
sequencing data	43
mrna vaccines	43
potential intermediate	43
asymptomatic carrier	43
inflammatory mediators	43
generation sequencing	43
may affect	43
like disease	43
like virus	43
lung inflammation	43
cardiovascular diseases	43
blood mononuclear	43
dendritic cell	43
recent report	43
porcine epidemic	43
genetic recombination	43
disseminated intravascular	43
viral vector	43
storm syndromes	43
based assays	43
calculated using	43
viral particle	43
study population	43
like covs	43
binding pocket	43
per ml	43
asymptomatic infection	43
less toxic	43
patient care	43
antiviral treatment	43
patient samples	43
viral infectivity	43
intravascular coagulation	43
effective vaccine	43
virus strains	42
note springer	42
rhesus monkeys	42
structural analysis	42
positive test	42
consider cytokine	42
docking study	42
human serum	42
hiv protease	42
laboratory tests	42
cruise ship	42
epidemiological data	42
recombinant human	42
direct viral	42
flow cytometry	42
therapeutic drugs	42
also detected	42
standard care	42
care facilities	42
will provide	42
primary human	42
renal failure	42
new drugs	42
potent neutralization	42
phase trial	42
newly discovered	42
recently published	42
immunofluorescence assay	42
igg assay	42
label non	42
systemic lupus	42
early diagnosis	42
virus assembly	42
study protocol	42
recent insights	42
nlrp inflammasome	42
aged years	42
important lessons	42
whole blood	42
lymph node	42
deep learning	42
expression vector	42
positive result	41
first time	41
human immune	41
lupus erythematosus	41
probe sets	41
vivo studies	41
low viral	41
vitro activity	41
natural killer	41
coronavirus fusion	41
physical distancing	41
infected macaques	41
culture medium	41
severely affected	41
recent reports	41
high prevalence	41
epidemiological characteristics	41
emerging coronavirus	41
viral antigens	41
preliminary results	41
two weeks	41
host defense	41
human clinical	41
therapeutic strategy	41
soluble ace	41
suspected cases	41
aged mice	41
accession number	41
total rna	41
coronaviruses sars	41
molecular mechanism	41
negative rt	41
sars pathogenesis	41
infected vero	41
rapid development	41
molecular modeling	41
ct value	41
influenza vaccination	41
epidemic diarrhea	41
substrate specificity	41
health concern	40
virus isolation	40
transmission route	40
highly potent	40
artificial intelligence	40
diagnostic assays	40
lactate dehydrogenase	40
therapeutic potential	40
four genera	40
global initiative	40
air samples	40
therapeutic interventions	40
therapeutic development	40
patients presenting	40
cycle threshold	40
seq data	40
cardiovascular complications	40
virus rna	40
type pneumocytes	40
natural reservoirs	40
review article	40
saliva samples	40
causes severe	40
polyclonal antibodies	40
detecting sars	40
effective vaccines	40
coronavirus pandemic	40
cov ratg	40
asymptomatic infections	40
nasal cavity	40
rna oligonucleotide	40
analyzed using	40
also shown	40
clinical development	40
coronavirus diseases	40
viruses related	40
chinese horseshoe	40
peptide substrates	40
washington state	40
severe lung	40
elderly patients	40
testing positive	40
network analysis	40
human cov	40
nonstructural protein	40
host proteases	39
dimer interface	39
cov transmission	39
mediated immunity	39
human proteins	39
analysis revealed	39
associated pneumonia	39
chronic obstructive	39
whole virus	39
review board	39
diagnostic tools	39
newly emerged	39
blood vessels	39
serological assay	39
proteolytic processing	39
ang ii	39
intrauterine vertical	39
like symptoms	39
significant differences	39
animal host	39
adult inpatients	39
time point	39
ncov infected	39
cd cd	39
global spread	39
may explain	39
relatively high	39
human disease	39
may increase	39
disease outbreak	39
clinically approved	39
influenza infection	39
viral life	39
two cases	39
neuroinvasive potential	39
clinical progression	39
newly identified	39
cerebrovascular disease	39
environmental contamination	39
although sars	39
protective effect	39
increased levels	39
subunit vaccines	39
bone marrow	39
potent antiviral	39
class ii	39
serological testing	39
swab samples	39
sequence data	39
like proteinase	39
plasma samples	39
mers coronaviruses	39
promising results	39
four structural	39
veroe cells	39
cov antibodies	39
mrna expression	39
genome structure	39
igm antibody	39
diagnostic methods	39
disease covid	39
early phase	39
chronic diseases	39
results show	38
febrile infants	38
surface glycoprotein	38
serological investigation	38
illness onset	38
transport medium	38
pilot study	38
pneumonia cases	38
human metapneumovirus	38
animal studies	38
extended data	38
term care	38
cov antibody	38
pathological changes	38
among different	38
comparative analysis	38
protein structure	38
viral membrane	38
acid sphingomyelinase	38
pangolin cov	38
north america	38
new human	38
tissue tropism	38
situ hybridization	38
inactivated virus	38
nucleotide sequence	38
also identified	38
growth factor	38
blood cell	38
lung epithelial	38
subunit vaccine	38
viral activity	38
cysteine residues	38
respiratory secretions	38
spread rapidly	38
natural selection	38
affected patients	38
unclear whether	38
neonates born	38
synonymous mutations	38
maximum likelihood	38
adenovirus type	38
similar results	38
medical center	38
aerosol transmission	38
long term	38
oral mucosa	38
binding motif	37
natural reservoir	37
well known	37
data set	37
obstructive pulmonary	37
active sars	37
receptor angiotensin	37
cov genomes	37
ethics committee	37
data sets	37
clinical evidence	37
antiviral response	37
vaccine induces	37
clinical benefit	37
emerging viruses	37
two studies	37
cytokine responses	37
controlled trials	37
companion animals	37
age groups	37
potent binding	37
least days	37
march th	37
expression profiling	37
inflammatory cells	37
two subunits	37
among adults	37
institutional review	37
gastrointestinal infection	37
aldosterone system	37
umbilical cord	37
vaccine efficacy	37
false positive	37
previous reports	37
critical illness	37
publicly available	37
inhibit viral	37
human intestinal	37
care units	37
oral route	37
immune function	37
protective role	37
liver injury	37
combination therapy	37
syrian hamsters	37
protein sequences	37
higher viral	37
final concentration	37
control strategies	37
plasma treatment	36
candidate drugs	36
antigen presentation	36
coronavirus pathogenesis	36
molecular basis	36
healthy controls	36
times higher	36
confirmed case	36
hydrophobic interactions	36
studies reported	36
standard deviation	36
therapeutic option	36
medical staff	36
human body	36
airway epithelia	36
first two	36
docking studies	36
surface area	36
macrophage activation	36
cell subsets	36
replicase polyprotein	36
acid test	36
phylogenetic analyses	36
virus vaccines	36
previous sars	36
viral transport	36
autoimmune diseases	36
ct imaging	36
small animal	36
study demonstrated	36
first week	36
clinical application	36
spike gene	36
positive rt	36
quantitative rt	36
disease patients	36
nk cells	36
immune activation	36
inflammatory bowel	36
genome analysis	36
posterior oropharyngeal	36
ischemic stroke	36
visiting wuhan	36
healthcare settings	36
research team	36
huanan seafood	36
approved drug	36
igm iga	36
viral pathogens	36
negative test	36
cutaneous manifestations	36
acid sequences	36
genus betacoronavirus	36
mm tris	36
fatality rates	36
blocking sars	36
authors contributed	36
protein palmitoylation	35
domesticated animals	35
several clinical	35
cov vaccines	35
humoral immunity	35
rapidly evolving	35
protein structures	35
corticosteroid treatment	35
past years	35
infectious agents	35
virus detection	35
specimen collection	35
goat anti	35
healthy adults	35
cell membranes	35
domain bound	35
sialic acid	35
binding free	35
clinical manifestation	35
reference genome	35
wuhan outbreak	35
clinical evaluation	35
suspected covid	35
viral attachment	35
membrane vesicles	35
binding affinities	35
influenza data	35
high throughput	35
patients recovered	35
emerging viral	35
nan doi	35
medical history	35
ec values	35
ex vivo	35
genomic sequence	35
first covid	35
studies suggest	35
study sars	35
randomised controlled	35
four patients	35
convalescent serum	35
attenuated vaccines	35
additional file	35
zoonotic coronaviruses	35
respiratory support	35
since sars	35
peptide vaccine	35
human beings	35
secondary antibody	35
nitric oxide	35
median time	34
magnetic resonance	34
fold higher	34
escherichia coli	34
inflammatory diseases	34
sars patient	34
significant increase	34
infection causes	34
study intervention	34
safety profile	34
clinical sensitivity	34
samples obtained	34
nasal epithelial	34
inanimate surfaces	34
coronavirus using	34
graphpad prism	34
camel mers	34
serial dilutions	34
studies also	34
immune cell	34
functional assessment	34
clinical predictive	34
potential anti	34
ground glass	34
camostat mesylate	34
cell immunity	34
acid amplification	34
underlying diseases	34
laboratory findings	34
asymptomatic contact	34
accepted article	34
lessons learned	34
attenuated sars	34
prolonged viral	34
coronavirus detection	34
data obtained	34
common marmoset	34
different sars	34
bacterial infections	34
future research	34
cell proteases	34
stimulated gene	34
recombination events	34
shed light	34
binding domains	34
human dpp	34
oropharyngeal saliva	34
virus load	34
bowel disease	34
using clinical	34
rbd domain	34
smooth muscle	34
inhibitory effects	34
different populations	34
mice transgenic	34
cellular immunity	34
clinical use	34
cytokine levels	34
less likely	34
coronavirus covid	34
reference sequences	34
rapidly spread	34
high dose	33
three patients	33
airway epithelium	33
quality control	33
catalytic domain	33
patients affected	33
mediated immune	33
cytokines chemokines	33
mitochondrial matrix	33
kidney disease	33
infectious cdna	33
bioinformatics analysis	33
cord blood	33
herbal medicines	33
health professionals	33
increasing number	33
species barrier	33
target protein	33
genetic analysis	33
infected persons	33
united arab	33
may represent	33
gastroenteritis virus	33
derived cms	33
also suggested	33
ii clinical	33
transplant recipients	33
convalescent individuals	33
infectious sars	33
arab emirates	33
intestinal epithelial	33
moderate covid	33
possible mechanisms	33
cellular receptors	33
natural infection	33
lysis buffer	33
body fluids	33
based sars	33
observational studies	33
spectrum inhibitors	33
near future	33
acid changes	33
entry inhibitors	33
protocol amendment	33
protein priming	33
analysis using	33
infections caused	33
discovered coronavirus	33
detection rate	33
key residues	33
civet cats	33
zhejiang province	33
community outbreak	33
enteric involvement	33
single cell	33
control study	33
current covid	33
many patients	33
catalytic dyad	33
i interferons	33
receptor antagonist	33
viral vectors	33
like viruses	33
dromedary mers	33
surgical masks	33
genomic data	33
golden syrian	33
ace gene	33
limited number	33
see table	33
mers cov	33
severe pulmonary	33
ps peptide	33
pluripotent stem	33
mutation rates	32
therapeutic intervention	32
mucosal immune	32
significantly associated	32
body weight	32
potential antiviral	32
endothelial dysfunction	32
primer probe	32
also called	32
negative controls	32
blood cells	32
mild cases	32
antiviral agent	32
bat ace	32
nucleotide identity	32
fecal viral	32
viral sequences	32
studies using	32
gastrointestinal manifestations	32
prevent infection	32
protease activity	32
protein gene	32
direct evidence	32
healthy blood	32
natural compounds	32
cell therapy	32
risk assessment	32
emerging novel	32
drugs targeting	32
recombinant adenovirus	32
cov disease	32
two distinct	32
fully understood	32
health officials	32
patients undergoing	32
severe infection	32
protease provides	32
develop severe	32
lead compounds	32
small number	32
pcr analysis	32
five patients	32
serially diluted	32
cov challenge	32
spike glycoproteins	32
lung failure	32
two sars	32
exclusion criteria	32
differential diagnosis	32
reproductive number	32
previously published	32
treating sars	32
throat swab	32
neutralize sars	32
sensory neurons	32
cov strain	32
rna detection	32
subcellular localization	32
clinical diagnosis	32
large scale	32
lower levels	32
site absent	32
vascular endothelial	32
clinical isolates	32
antibody titer	32
vital role	32
mean age	32
host interactions	31
small sample	31
san diego	31
geographical locations	31
molecular diagnosis	31
enrichment analysis	31
thrombotic complications	31
epidemiological studies	31
juvenile animals	31
zebrafish larvae	31
syndrome virus	31
effective antiviral	31
available evidence	31
knee arthroplasty	31
genetic variation	31
ncov contains	31
disease transmission	31
cysteine proteases	31
submitted work	31
active compounds	31
different human	31
diarrhea virus	31
glass opacity	31
avian coronaviruses	31
toxic derivative	31
order nidovirales	31
treatment option	31
optimized dosing	31
virus particle	31
inhibitor targeting	31
ii pneumocytes	31
cytoplasmic tail	31
systems biology	31
transmembrane domain	31
studies will	31
candidate sars	31
med doi	31
final manuscript	31
molecular evolution	31
clinical microbiology	31
different species	31
ec value	31
nucleocapsid proteins	31
cause mild	31
antigen detection	31
molecular patterns	31
human mab	31
reservoir host	31
protein receptor	31
mg twice	31
high degree	31
positive cells	31
immune cross	31
significant reduction	31
fusion core	31
clinical disease	31
host innate	31
dosing design	31
cytokine storms	31
necrotizing encephalopathy	31
igm igg	31
large amounts	31
much lower	31
human receptor	31
masked palm	31
fatal cases	31
drinking water	31
cynomolgus macaques	31
protein synthesis	31
quantitative detection	31
common ancestor	31
single center	31
molecular targets	31
respiratory epithelium	31
sars vaccine	31
major role	31
first line	31
interferon response	31
transcription loop	31
viral strains	31
long time	31
molecular testing	31
young children	31
death rate	31
mouse igg	30
environmental conditions	30
million confirmed	30
many studies	30
cases reported	30
may reflect	30
reduce viral	30
bsc alone	30
bat covs	30
computational methods	30
single nucleotide	30
copy number	30
coronavirus epidemic	30
animal reservoir	30
possible cause	30
ion channel	30
using different	30
hyperimmune plasma	30
different animal	30
temporal dynamics	30
repurposed drugs	30
expressing sars	30
ketoamide inhibitors	30
million cases	30
protective measures	30
developed using	30
cov pathogenesis	30
face mask	30
data available	30
reactive oxygen	30
study period	30
pro inhibitors	30
treat sars	30
differential expression	30
novel coronaviruses	30
engineered human	30
induced acute	30
vaccine targets	30
unexposed individuals	30
based drug	30
like illness	30
outcomes among	30
associated protein	30
inflammatory markers	30
causing covid	30
two independent	30
neutralization activity	30
disease onset	30
fusion mechanism	30
green monkeys	30
patients also	30
generating procedures	30
hace transgenic	30
brain tissue	30
feline coronavirus	30
acute myocardial	30
nucleotide sequences	30
sars vaccines	30
side chain	30
infections among	30
european countries	30
literature search	30
new drug	30
using rt	30
invasive mechanical	30
identify potential	30
mm nacl	30
pneumonia caused	30
pro enzymes	30
based epidemiology	30
infection rate	30
moderate coronavirus	30
step rt	30
highly infectious	30
human sera	30
ongoing pandemic	30
virus binding	30
across different	30
nsp protein	30
multiple organs	30
evolutionary history	30
extraction kit	29
comprehensive review	29
infects human	29
block sars	29
domestic animals	29
within hours	29
serum albumin	29
health system	29
treatment group	29
statistical analyses	29
predict potential	29
carrier transmission	29
predictive value	29
advanced age	29
multiple shedding	29
using two	29
highly effective	29
cov nucleocapsid	29
first wave	29
patients requiring	29
gene source	29
healthy individuals	29
also revealed	29
human protein	29
bovine coronavirus	29
pulmonary pathology	29
measured using	29
among humans	29
viral mrna	29
care providers	29
causing severe	29
high specificity	29
expressed genes	29
days later	29
inclusion criteria	29
short period	29
copy numbers	29
mammalian cells	29
sars infection	29
oxygen species	29
following infection	29
associated molecular	29
propensity score	29
care settings	29
specific antiviral	29
supplementary materials	29
assay using	29
experimentally infected	29
older age	29
oxygen therapy	29
viral detection	29
study using	29
swab specimens	29
host cellular	29
mg dl	29
twice daily	29
access article	29
chinese medicines	29
presumed asymptomatic	29
genomic epidemiology	29
prospective cohort	29
first confirmed	29
naturally occurring	29
bat species	29
full length	29
serum levels	29
dynamics simulation	29
functional characterization	29
rectal swabs	29
ncov pneumonia	29
i ifns	29
wide variety	29
convalescent sars	29
higher mortality	29
genetic sequence	29
mg day	29
ct postponement	29
international concern	29
skilled nursing	29
coronavirus genomes	29
wuhan clinical	29
article distributed	29
also present	29
broad range	29
activation syndrome	29
medical conditions	29
plaque reduction	29
sense single	29
human antibody	29
among healthcare	29
zoonotic transmission	29
exact test	29
developing severe	29
antiviral properties	28
full genome	28
vast majority	28
luciferase activity	28
medicinal chemistry	28
hyaline membrane	28
md simulations	28
additional studies	28
gut microbiota	28
current outbreak	28
rna expression	28
cov viral	28
future outbreaks	28
zoonotic origin	28
inhibited sars	28
iga antibodies	28
transmission rate	28
host proteins	28
inactivated whole	28
healthcare professionals	28
without permission	28
diamond princess	28
china coronavirus	28
covalent bond	28
fully human	28
coronavirus family	28
genbank accession	28
community spread	28
ucsf chimera	28
severe forms	28
infectious agent	28
west nile	28
tyrosine kinase	28
fold change	28
first report	28
wastewater samples	28
may induce	28
cell cycle	28
protease cleavage	28
original author	28
coronavirus strains	28
two days	28
two main	28
short time	28
infected cases	28
drug candidate	28
vero cell	28
obtained using	28
virus genome	28
shedding routes	28
immunological studies	28
different stages	28
constructed using	28
tissue sections	28
ace interaction	28
pneumonia clinical	28
associated sars	28
among sars	28
sperm banking	28
diseases like	28
first sars	28
genome encodes	28
allowed without	28
receptor expression	28
scoping review	28
symptom resolution	28
cancer cells	28
vaccine platform	28
many cases	28
olfactory dysfunction	28
cell proliferation	28
inflammatory drugs	28
adaptive evolution	28
way anova	28
coronary artery	28
increases infectivity	28
lethal disease	28
pediatric sars	28
soluble human	28
clinical severity	28
pathogenic viruses	28
tract specimens	28
western medicine	28
older people	28
novel severe	28
nuclear factor	28
antibodies directed	28
new cases	28
leader sequence	28
chinese herbal	28
human bronchial	28
time period	28
temporal profiles	28
genome composition	28
human organs	28
reuse allowed	28
hydroxyl group	28
different parts	28
peptide substrate	28
rapid transmission	27
st century	27
chronic respiratory	27
different cell	27
iii clinical	27
tissue samples	27
rna polymerases	27
site residues	27
ace levels	27
human antibodies	27
different organs	27
antibody therapy	27
neutralising antibody	27
infected patient	27
treat patients	27
igg elisa	27
human primate	27
protein may	27
rna binding	27
multiorgan failure	27
mediated inflammatory	27
beta coronavirus	27
faecal samples	27
host species	27
der waals	27
novel therapeutic	27
neurological involvement	27
protein induces	27
retrospective review	27
important roles	27
acid testing	27
clinical testing	27
rapid diagnostic	27
trained immunity	27
patients diagnosed	27
infection among	27
pangolin origin	27
stimulating factor	27
extracellular traps	27
may act	27
specimens collected	27
cytopathic effects	27
symptomatic individuals	27
three days	27
turnaround time	27
venous thromboembolism	27
barr virus	27
acute sars	27
antibody assays	27
studies revealed	27
interquartile range	27
provide evidence	27
neutralisation assays	27
vaccine platforms	27
ii receptor	27
pathogenic mechanisms	27
fetal bovine	27
conserved among	27
coronavirus cl	27
ace shedding	27
chemoattractant protein	27
old man	27
brain organoids	27
using molecular	27
peptide bond	27
possible explanation	27
cells using	27
therapeutic agent	27
specific sars	27
among covid	27
controlled clinical	27
peritonitis virus	27
human brain	27
architect sars	27
nile virus	27
selection pressure	27
will likely	27
nursing facility	27
may serve	27
plasma transfusion	27
pivotal role	27
transmitted via	27
macrophage responses	27
au ml	27
pharyngeal swabs	27
dis doi	27
force field	27
mhc class	27
endocytic pathway	27
reported confirmed	27
provide insight	27
six patients	27
viral structural	27
improves outcome	27
plasmacytoid dendritic	27
virus cell	27
sars pneumonia	27
humoral responses	26
domain iii	26
takes place	26
block viral	26
highly susceptible	26
patient cohort	26
coronavirus causing	26
recently reported	26
hydrogen bonding	26
specific cell	26
drug screening	26
health systems	26
membrane formation	26
may include	26
molecular evolutionary	26
nsp complex	26
patients randomized	26
will require	26
time horizon	26
pulmonary edema	26
different time	26
mediated endocytosis	26
virus strain	26
ongoing wuhan	26
salt bridge	26
neutrophil extracellular	26
inflammatory activity	26
animal reservoirs	26
comparative study	26
electron microscope	26
vaccination strategies	26
covalent docking	26
active sites	26
dimer levels	26
existing drugs	26
information regarding	26
receiving hydroxychloroquine	26
viral polymerase	26
rna levels	26
sustentacular cells	26
sars drugs	26
neutralizing anti	26
andrological services	26
laboratory confirmed	26
resonance imaging	26
pandemic caused	26
virus clearance	26
induced dimerization	26
ace may	26
monocyte chemoattractant	26
cov proteins	26
lymphocyte ratio	26
regarding sars	26
homology modelling	26
parainfluenza virus	26
pg ml	26
storm syndrome	26
written informed	26
intermediate animal	26
conjunctival secretions	26
combat covid	26
antiviral therapies	26
kidney cells	26
reduced viral	26
potent inhibitors	26
recognition receptors	26
chest radiograph	26
also demonstrated	26
commons licence	26
recombination event	26
respiratory pathogen	26
rnadependent rna	26
positive pcr	26
another important	26
hpa axis	26
human covid	26
lymphocyte counts	26
health crisis	26
readily available	26
specific treatment	26
viral genomic	26
therapeutic approaches	26
medical countermeasures	26
green monkey	26
ace mrna	26
prevent covid	26
viral genes	26
first patient	26
viral invasion	26
potential conflict	26
mini kit	26
seasonal influenza	26
clinical presentations	26
using sars	26
prior infection	26
macaque model	26
cell lysates	26
potential inhibitor	26
studies suggested	26
virus fusion	26
asymptomatic transmission	25
ligand binding	25
promising drug	25
functional basis	25
optical density	25
endosomal ph	25
rna dependent	25
people worldwide	25
glycosylation sites	25
infection diagnosis	25
hospital stay	25
mass testing	25
old male	25
nine pregnant	25
creatine kinase	25
media briefing	25
sensitive detection	25
highly purified	25
adults aged	25
grade soluble	25
viral disease	25
research group	25
expressing human	25
transmission via	25
symptomatic patient	25
regression model	25
mechanisms underlying	25
eye protection	25
serum dilution	25
critical covid	25
nationwide analysis	25
point mutations	25
clinical therapies	25
host interactome	25
olfactory sensory	25
clinical settings	25
different geographical	25
candidate vaccine	25
literature review	25
cells may	25
pro cleavage	25
may require	25
coronavirus study	25
potential evidence	25
lung function	25
antibodies may	25
gene ontology	25
productive infection	25
logistic regression	25
will continue	25
still unknown	25
research groups	25
important target	25
contact precautions	25
live sars	25
tissues using	25
transcription factors	25
drug treatment	25
amniotic fluid	25
main target	25
findings indicate	25
expressing ace	25
limited data	25
attenuated virus	25
mtase activity	25
infect human	25
virus challenge	25
chest computed	25
guinea pigs	25
ray structure	25
human infections	25
likely due	25
persistent fecal	25
experimental infection	25
antibody blocking	25
continuous variables	25
protein rbd	25
rapid test	25
neutralization capacity	25
mass spectrometry	25
recent evidence	25
primate models	25
serologic assays	25
based design	25
significantly increased	25
natural host	25
increased expression	25
study revealed	25
binding mode	25
based analysis	25
remains unknown	25
detection methods	25
terminal region	25
blood group	25
genetically modified	25
encephalitis associated	25
systematic reviews	25
also contribute	25
results demonstrate	25
beneficial effects	25
therapeutic approach	25
expression profile	25
princess cruise	25
viral surface	25
linear regression	25
older patients	25
well plate	25
young adults	25
alveolar type	25
disease spread	25
also play	25
pandemic covid	25
domestic cats	25
randomized trial	25
electron density	25
plasma levels	25
chloroquine hydroxychloroquine	25
center experience	25
hierarchical clustering	25
vectored covid	25
escape mutants	25
positive correlation	25
significant role	25
two types	25
secondary antibodies	24
severe outcomes	24
polybasic cleavage	24
transport media	24
human trial	24
pandemic potential	24
low prevalence	24
coronavirus isolates	24
among individuals	24
heart rate	24
china sars	24