This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-001938-n2d5fw2f | Immortal time bias in critical care research: application of timevarying Cox regression for observational cohort studies Effectiveness of inhaled corticosteroids in chronic obstructive pulmonary disease: immortal time bias in observational studies Coreactivation of human herpesvirus 6 and cytomegalovirus is associated with worse clinical outcome in critically ill adults Immunological insights into the pathogenesis of active CMV infection in non- immunosuppressed critically ill patients Detection of herpesvirus EBV DNA in the lower respiratory tract of ICU patients: a marker of infection of the lower respiratory tract? |
| cord-004515-x22q1f21 | Pregnancy or breast- feeding Opposition from the patient or his/ her relatives Protected major( Guardianship) Contraindication to the use of dornase alfa Known intolerance to dornase alfa Patient whose life expectancy is less than 24 h, according to the treating physician"Do not resuscitate"order Who will take informed consent? |
| cord-001215-aj8nxi3x | For both AECC and Berlin definitions, the ratio of pulse oximetric saturation to fraction of inspired oxygen( SpO 2/FiO 2) was used as a validated surrogate for PaO 2/FiO 2 among patients without an arterial blood gas measurement at the time of ALI/ ARDS diagnosis: SpO 2/FiO 2= 64? 0.84 9 |
| cord-002078-38rmx65j | Stefano title: Can fiberoptic bronchoscopy be applied to critically ill patients treated with noninvasive ventilation for acute respiratory distress syndrome? |
| cord-003219-iryb3v0z | the APRONET( ARDS Prone Position Network) study Dynamic driving pressure associated with mortality in acute respiratory distress syndrome with extracorporeal membrane oxygenation Driving pressure: a marker of severity, a safety limit, or a goal for mechanical ventilation? |
| cord-002540-hgx0bfbz | Can glypican-3 be a disease- specific biomarker? |
| cord-000492-ec5qzurk | : where are we now? |
| cord-000492-ec5qzurk | the transduction effi ciency of recombinant vectors GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium Spatial and temporal expression of surfactant proteins in hyperoxia- induced neonatal rat lung injury Intrapulmonary TNF gene therapy reverses sepsis- induced suppression of lung antibacterial host defense Clinical Review: Gene- based therapies for ALI/ ARDS: where are we now? |
| cord-001661-dj9bxhwb | An early PEEP/ FiO2 trial identifies different degrees of lung injury in patients with acute respiratory distress syndrome Acute respiratory distress syndrome 40 years later: time to revisit its definition Are we able to optimize the definition and diagnosis of severe acute respiratory distress syndrome? |
| cord-003615-vpzzsdld | : is there a clinical relevance? |
| cord-004385-xna32qve | The initial intentions of corticosteroid therapy were unclear( was it used as a rescue therapy or due to COPD/ asthma exacerbation or due to pneumonia/ ARDS?). |
| cord-005941-e4fvj54l | A Immunologic consequences of exogenous surfactint administration Degradation of pulmonary surfactant disaturated phosphatidylcholines by alveolar macrophages Hypertrophy and hyperplasia of alveolar type II cells in response to silica and other pulmonary toxicants Adverse effects of toxins and drugs on the surfactant systems Causes of mortality in patients with the adult respiratory distress syndrome Toxicological data on NOx: an overview Pulmonary surfactant: physiology, pharmacology and clinical uses Exogenous surfactant treatment for the adult respiratory distress syndrome? |
| cord-010509-gipjuhhc | Krebs cycle reimagined: the emerging roles of succinate and Itaconate as signal transducers Enhancement of glycolysis by inhibition of oxygen- sensing prolyl hydroxylases protects alveolar epithelial cells from acute lung injury Acute respiratory distress syndrome: the Berlin definition l- Histidine, arachidonic acid, biliverdin, and l- cysteine- glutathione disulfide as potential biomarkers for cured pulmonary tuberculosis Amino acids and immune response: a role for cysteine, glutamine, phenylalanine, tryptophan and arginine in T- cell function and cancer? |
| cord-006700-df8ard9o | Complete resolution of life- threatening bleomycin- induced pneumonitis after treatment with imatinib mesylate in a patient with Hodgkin's lymphoma: hope for severe chemotherapy- induced toxicity? |
| cord-017126-7ebo3cy3 | Definitions, mechanisms, relevant outcomes, and clinical trial coordination Effect of a protective- ventilation strategy on mortality in the acute respiratory distress syndrome Recruitment maneuvers in acute lung injury Exogenous surfactant replacement in ARDS-one day, someday, or never? |
| cord-016142-7j5cdt1b | Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans H2O2 and genistein differentially modulate protein tyrosine phosphorylation, endothelial morphology, and monolayer barrier function Chronic granulomatous disease: more than the lack of superoxide? |
| cord-005812-hx6lkuj0 | acute lung injury Alveolar epithelial barrier functions in ventilated perfused rabbit lungs Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome? |
| cord-005812-hx6lkuj0 | what have we learned from animal models and clinical studies? |
| cord-012587-h3c9novk | COVID-19 pneumonia: ARDS or not? |
| cord-012587-h3c9novk | COVID-19 pneumonia: different respiratory treatment for different phenotypes? |
| cord-004450-daxz9yhp | Intravenous iloprost to recruit the microcirculation in septic shock patients? |
| cord-004450-daxz9yhp | which route is superior in experimental pig lung transplantation: inhaled or intravenous? |
| cord-018685-i7s04fh5 | a study of 8 autopsy cases from Singapore Pulmonary pathology of severe acute respiratory syndrome in Toronto Pathological study on severe acute respiratory syndrome Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in- situ hybridization study of fatal cases Epithelial stem cells of the lung: privileged few opportunities for many? |
| cord-000539-uh3q65we | A Strain- Dependent Pathogenesis in Fatal H1N1 and H5N1 Subtype Infections of Mice Animal models for the study of influenza pathogenesis and therapy Transmission and pathogenesis of swine- origin 2009 A( H1N1) influenza viruses in ferrets and mice Variations in the Hemagglutinin of the 2009 H1N1 Pandemic Virus: Potential for Strains with Altered Virulence Phenotype? |
| cord-000539-uh3q65we | Pandemic Influenza A( H1N1) Virus Affects Receptor Binding Observed association between the HA1 mutation D222 G in the 2009 pandemic influenza A(H1N1) virus and severe clinical outcome Markers for predicting the development of acute respiratory distress syndrome Radiological prognostic factors in patients with pandemic H1N1( pH1N1) infection requiring hospital admission Serial Histopathological Examination of the Lungs of Mice Infected with Influenza A Virus PR8 Strain Pulmonary surfactant in health and human lung diseases: state of the art Serial changes in surfactant- associated proteins in lung and serum before and after onset of ARDS Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-013306-35jiycem | an emerging consensus on rating quality of evidence and strength of recommendations Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome Neuromuscular blocking agents decrease inflammatory response in patients presenting with acute respiratory distress syndrome Clinical study of early use of neuromuscular blocking agents in patients with severe sepsis and acute respiratory distress syndrome Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome To retain spontaneous breathing or eliminate spontaneous breathing with neuromuscular blockers in acute respiratory distress syndrome patients? |
| cord-266067-wrouqdcj | In vivo lung perfusion rehabilitates sepsis- induced lung injury EVLP: Ready for Prime Time? |
| cord-253355-dii5zszf | a multicenter European study Higher mortality rate in ventilated COVID-19 patients in large sample Lower mortality of COVID-19 by early recognition and intervention: experience from Jiangsu Province Angiopoietin signaling in the vasculature Interactions between mechanical and biological processes in acute lung injury Biomarkers for the acute respiratory distress syndrome: how to make the diagnosis more precise The gravitational distribution of ventilation- perfusion ratio is more uniform in prone than supine posture in the normal human lung Acute respiratory distress syndrome caused by pulmonary and extrapulmonary disease: different syndromes? |
| cord-004462-e8fbg6i6 | Electrical impedance tomography: functional lung imaging on its way to clinical practice? |
| cord-004462-e8fbg6i6 | Monitoring perioperative changes in distribution of pulmonary ventilation by functional electrical impedance tomography Identification of regional overdistension, recruitment and cyclic alveolar collapse with electrical impedance tomography in an experimental ARDS model High- frequency oscillatory ventilation in adults with ARDS: past, present, and future High- frequency oscillatory ventilation: still a role? |
| cord-023890-z346hh2c | Effects of fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases n-3 fatty acids, inflammation and immunity: new mechanisms to explain old actions Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? |
| cord-023890-z346hh2c | PUFAs and Lung Injury: Nutrients or Drugs? |
| cord-029646-oujgcciq | respiratory distress syndrome Magnitude and time course of acute hypoxic pulmonary vasoconstriction in man Hypoxia- induced inflammation in the lung: a potential therapeutic target in acute lung injury? |
| cord-254083-ea94wn3f | -case series Comparison of the Berlin definition for acute respiratory distress syndrome with autopsy Ventilator- associated lung injury in patients without acute lung injury at the onset of mechanical ventilation COVID-19 does not lead to a"typical COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-254083-ea94wn3f | H. COVID-19 does not lead to a"typical COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-025163-iyh0d6mj | An adult case of severe life- threatening mycoplasma pneumoniae pneumonia due to a macrolide- resistant strain, Japan: a case report Mycoplasma pneumoniae in pediatric patients: do macrolide- resistance and/or delayed treatment matter? |
| cord-025163-iyh0d6mj | Does noninvasive ventilation work in ARDS? |
| cord-005621-a4bspoii | Mayo Foundation, Rochester 26 Evaluation of outcome scoring systems for patients on extracorporeal membrane oxygenation Impact of preexisting organ dysfunction on extracorporeal life support for nonpostcardiotomy cardiopulmonary failure Predictors of mortality in patients successfully weaned from extracorporeal membrane oxygenation Prognosis of patients on extracorporeal membrane oxygenation: the impact of acute kidney injury on mortality Is it possible to predict outcome in pulmonary ECMO? |
| cord-005621-a4bspoii | The best cutoff value was identified as the point with the highest sensitivity and specificity( Youden index: SE? SP-1). |
| cord-005621-a4bspoii | What is the niche for extracorporeal membrane oxygenation in severe acute respiratory distress syndrome? |
| cord-102679-6dpo073b | Is a New Player Emerging in Critical Care Sedation? |
| cord-102679-6dpo073b | Nat Rev Dis Primers COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted? |
| cord-019010-9xgwjvsv | Clinical signs and symptoms predicting influenza infection Early administration of oral oseltamivir increases the benefits of influenza treatment Impact of oseltamivir treatment on influenza- related lower respiratory tract complications and hospitalizations Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario Viral infections in immunocompromised patients: what's new with respiratory viruses? |
| cord-019010-9xgwjvsv | Influenza pneumonia: a descriptive study Influenza infection and risk of acute pulmonary embolism Anticoagulants for acute respiratory distress syndrome: can they work? |
| cord-003198-1kw5v6rm | A new simplified acute physiology score( SAPS II) based on a European/ North American multicenter study Delivered oxygen concentrations using low- flow and high- flow nasal cannulas Early identification of acute respiratory distress disorder in the absence of positive pressure ventilation: implications for revision of the berlin criteria for acute respiratory distress syndrome Interstitial lung disease associated with the idiopathic inflammatory myopathies: what progress has been made in the past 35 years? |
| cord-003198-1kw5v6rm | Do we need ARDS? |
| cord-003198-1kw5v6rm | Medicine( Baltimore) Interstitial pneumonia with autoimmune features: an additional risk factor for ARDS? |
| cord-035326-qjp37j7x | Jiangsu Province Early self- proning in awake non- intubated patients in the emergency department: a single ED's experience during the COVID-19 pandemic Is the prone position helpful during spontaneous breathing in patients with cOVID-19? |
| cord-035326-qjp37j7x | Monitor for desaturation at 15 min of each position change When to stop PP? |
| cord-257613-o0q7hvn3 | 6.3| What can we expect to learn from this pandemic( with new clinical trials approved)? |
| cord-011197-bmigh2rs | Airway pressure release ventilation: what do we know? |
| cord-011197-bmigh2rs | Does airway pressure release ventilation offer important new advantages in mechanical ventilator support? |
| cord-011197-bmigh2rs | Should airway pressure release ventilation be the primary mode in ARDS? |
| cord-261146-ppe8br4z | Are We Closing the Circle? |
| cord-252085-8dq3gdo8 | Regarding acute respiratory distress syndrome( ARDS), which of the following summarizes the best ventilation strategy? |
| cord-252085-8dq3gdo8 | We confirm that we have provided a current, correct email address which is accessible by the Corresponding Author and which has been configured to accept email from( Dr.maythem84@yahoo.com) Signed by the author: Which of the following is true about primary spontaneous pneumothorax? |
| cord-278249-vvhq9vgp | Is a"cytokine storm"relevant to COVID-19? |
| cord-011363-o1f398vn | Early neuromuscular blockade in the acute respiratory distress syndrome Does prone positioning increase intracranial pressure? |
| cord-011363-o1f398vn | Should we use driving pressure to set tidal volume? |
| cord-011363-o1f398vn | What is the relationship? |
| cord-003832-q1422ydi | Acute respiratory distress syndrome mimickers lacking common risk factors of the Berlin definition Etiologies, diagnostic work- up and outcomes of acute respiratory distress syndrome with no common risk factor: a prospective multicenter study Rare respiratory diseases in the ICU: when to suspect them and specific approaches Serological and morphological prognostic factors in patients with interstitial pneumonia with autoimmune features research statement: interstitial pneumonia with autoimmune features Interstitial pneumonia with autoimmune features: an additional risk factor for ARDS? |
| cord-003832-q1422ydi | Ann Intensive Care Blood platelets and sepsis pathophysiology: a new therapeutic prospect in critical ill patients? |
| cord-003832-q1422ydi | New insights on a complex relationship Coagulation, fibrinolysis, and fibrin deposition in acute lung injury Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention? |
| cord-258087-93yfs7ve | A second generation human haplotype map of over 3.1 million SNPs What can genome- wide association studies tell us about the genetics of common disease? |
| cord-258087-93yfs7ve | What makes a good genetic association study? |
| cord-020490-sjz5mbbr | Following the same insult, why do some patients develop ARDS and others do not? |
| cord-020490-sjz5mbbr | How can we predict which critically ill patients are at higher risk of developing ARDS? |
| cord-271180-cnrs0zpg | With regards to the submission of Cytosorb Filter: An adjunct for survival in a COVID-19 patient in cytokine storm? |
| cord-271180-cnrs0zpg | cord-271180-cnrs0zpg authors: Rizvi, Saniya; Danic, Michael; Silver, Mark; LaBond, Virginia title: Cytosorb Filter: An adjunct for survival in the COVID-19 patient in cytokine storm? |
| cord-277590-u0uf88e7 | what next? |
| cord-308402-37i62atc | How Should Aerosols Be Delivered During Invasive Mechanical Ventilation? |
| cord-296656-4q0jdyrh | Zoek je verdieping in je vak? |
| cord-034469-ew90eef4 | Does regional lung strain correlate with regional inflammation in acute respiratory distress syndrome during nonprotective ventilation? |
| cord-034469-ew90eef4 | gold Open Access which fosters wider collaboration and increased citations maximum visibility for your research: over 100 M website views per year submit your research? |
| cord-002016-vzn338ub | Are the known effects of corticosteroids on the injured lung likely to reverse or stabilize lung injury in these catastrophically ill patients in a timely way? |
| cord-002016-vzn338ub | Do these short- term improvements in lung physiology with corticosteroids support their use as rescue therapies? |
| cord-002016-vzn338ub | Prolonged glucocorticoid treatment is associated with improved ARDS outcomes: analysis of individual patients'data from four randomized trials and trial- level meta- analysis of the updated literature Steroids for acute respiratory distress syndrome? |
| cord-002016-vzn338ub | Should they have? |
| cord-325755-n7vjjw9r | Is it real threat? |
| cord-006459-9kizif98 | All manipulations were performed under BSL-3? |
| cord-006459-9kizif98 | H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment? |
| cord-006459-9kizif98 | The pulmonary circulation of homozygous or heterozygous eNOS- null mice is hyperresponsive to mild hypoxia Molecular characterization of H9N2 influenza viruses: were they the donors of the''internal''genes of H5N1 viruses in Hong Kong? |
| cord-253129-v5lck9l7 | Evidence of barotrauma since enrolment? a. |
| cord-253129-v5lck9l7 | Not optimally resuscitated with fluids( e.g. stable blood pressure, but pulse pressure variation ≥ 12% because of inadequate left ventricular preload)? |
| cord-253129-v5lck9l7 | Yes A minimal algorithm for a minimal recruitment model- model estimation of alveoli opening pressure of an acute respiratory distress syndrome( ARDS) lung Patient- ventilator asynchrony during assisted mechanical ventilation Patient- ventilator asynchronies: may the respiratory mechanics play a role? |
| cord-256385-g1wcfrfi | SARS- CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Extracorporeal membrane oxygenation( ECMO): Does it have a role in the treatment of severe COVID-19? |
| cord-256385-g1wcfrfi | What drives neutrophils to the alveoli in ARDS? |
| cord-256385-g1wcfrfi | What's new? |
| cord-291481-ov1gkgpc | 2009 influenza virus detection by real time RT- PCR: is viral quantification useful? |
| cord-291481-ov1gkgpc | Detection of herpesvirus EBV DNA in the lower respiratory tract of ICU patients: a marker of infection of the lower respiratory tract? |
| cord-261370-jp5sqqwc | A Potential Treatment for COVID-19? |
| cord-261370-jp5sqqwc | COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-261370-jp5sqqwc | agonists or assistants? |
| cord-273426-55vu6b3u | Different respiratory treatments for different phenotypes? |
| cord-273426-55vu6b3u | For information regarding this article, E- mail: toshiiba@juntendo.ac.jp Acute pulmonary embolism and COVID-19 pneumonia: A random association? |
| cord-273426-55vu6b3u | Prominent changes in blood coagulation of patients with SARS- CoV-2 infection Will complement inhibition be the new target in treating COVID-19 related systemic thrombosis? |
| cord-277648-9kxwkcbl | COVID-19 pneumonia: ARDS or not? |
| cord-277648-9kxwkcbl | Should we stimulate or suppress immune responses in COVID-19? |
| cord-004092-wb150n8w | An experimental porcine study Stress distribution in lungs: a model of pulmonary elasticity Alterations of mechanical properties and morphology in excised rabbit lungs rinsed with a detergent Physiology in Medicine: understanding dynamic alveolar physiology to minimize ventilator- induced lung injury Alveolar derecruitment and collapse induration as crucial mechanisms in lung injury and fibrosis Alveolitis and collapse in the pathogenesis of pulmonary fibrosis Mechanical ventilation- associated lung fibrosis in acute respiratory distress syndrome: a significant contributor to poor outcome Opening pressures and atelectrauma in acute respiratory distress syndrome Does high PEEP prevent alveolar cycling? |
| cord-004092-wb150n8w | Does regional lung strain correlate with regional inflammation in acute respiratory distress syndrome during nonprotective ventilation? |
| cord-004092-wb150n8w | What's new in respiratory physiology? |
| cord-004092-wb150n8w | a systematic review Has mortality from acute respiratory distress syndrome decreased over time? |
| cord-266423-s8lqdpvn | Can body mass index predict clinical outcomes for patients with acute lung injury/ acute respiratory distress syndrome? |
| cord-266423-s8lqdpvn | Disprove the Obesity Paradox in Acute Respiratory Distress Syndrome? |
| cord-266423-s8lqdpvn | What could be causing the apparent difference in the severity of COVID-19 in patients with obesity compared with previous studies of ARDS in patients with obesity? |
| cord-256051-87alqfkd | A role for CT in COVID-19? |
| cord-256051-87alqfkd | Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA- Secondary Publication Is There a Role for Lung Ultrasound During the COVID-19 Pandemic? |
| cord-256051-87alqfkd | pneumonia: a random association? |
| cord-283779-mudwcypl | Compared to Standard of Care Treatment Favipiravir versus Arbidol for COVID-19: A Randomized Clinical Covid-19: trials of four potential treatments to generate"robust data"of what works Covid-19: what treatments are being investigated? |
| cord-283779-mudwcypl | How will COVID-19 and global trends in physical inactivity and sedentary behavior affect one another? |
| cord-305758-6twwcp47 | Is extracorporeal circulation the future of acute respiratory distress syndrome management? |
| cord-305758-6twwcp47 | The PRESERVE mortality risk score and analysis of longterm outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome ECMO for ARDS: from salvage to standard of care? |
| cord-005985-csc3lfbm | ( b) Which pathophysiological events encountered in the course of ARDS may be attributed to surfactant abnormalities? |
| cord-005985-csc3lfbm | Further diagnostic and therapeutic approaches will be necessary to elucidate the contribution of impaired surfactant function to the gas exchange abnormalities in ARDS, to define whether this contribution is critically dependent on the phase of the disease( large impact in early ARDS, small impact in late ARDS with fibrosis?), and thereby to provide a rational basis for surfactant replacement trials aimed at acutely improving gas exchange conditions in ARDS patients. |
| cord-005985-csc3lfbm | In patients with severe ARDS, however, reliable measurements of lung compliance are still difficult to perform, mostly because of uncertainties concerning lung volumes( at which part of the pressure- volume curve does the lung actually range?) |
| cord-005985-csc3lfbm | What is the present evidence for surfactant abnormalities in patients with ARDS? |
| cord-282474-74273qgk | The upper pressure will be determined to achieve a tidal volume of 6 ml/ kg lean body mass, while the respiratory rate will be set to maintain an arterial BGA?? |
| cord-282474-74273qgk | The upper pressure will be determined to achieve a tidal volume of 6 ml/ kg lean body mass, while the respiratory rate will be set to maintain an arterial BGA?? |
| cord-305389-n5cppi72 | The role of the soluble urokinase plasminogen activator( suPAR) in children with pneumonia Radiation induced apoptosis and pulmonary fibrosis: curcumin an effective intervention? |
| cord-305389-n5cppi72 | formyl peptide receptors novel targets for therapeutic intervention in ischaemia- reperfusion injury? |
| cord-284332-p4c1fneh | ALI/ ARDS The role of exogenous surfactant in the treatment of acute lung injury A mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindreds Target disruption of the surfactant protein B gene disrupts surfactant hemeostasis, causing respiratory failure in newborn mice Differential activity and lack of synergy of lung surfactant proteins SP B and SP C in interactions with phospholipids Surfactant inhibition by plasma proteins: differential sensitivity of various surfactant preparations Importance of hydrophobic apoproteins as constituents of clinical exogenous surfactants Is outcome from ARDS related to the severity of respiratory failure? |
| cord-284332-p4c1fneh | Injurious mechanical ventilation and end- organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome Does programmed cell death( apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? |
| cord-292862-ezrkg0dc | The 2016 ATS bear cage award- winning proposal The mercurial nature of neutrophils: still an enigma in ARDS? |
| cord-292862-ezrkg0dc | The multifaceted functions of neutrophils Neutrophils in the activation and regulation of innate and adaptive immunity What drives neutrophils to the alveoli in ARDS? |
| cord-003532-lcgeingz | Can myocardial perfusion imaging with echo contrast help recognise type 1 acute myocardial infarction in the critically ill? |
| cord-003532-lcgeingz | Is esmolol associated with worse outcome at the acute phase of ischemic stroke that receives thrombolysis? |
| cord-003532-lcgeingz | The question was"in situations where an expert opinion on an ultrasound is not immediately available, is it acceptable to get an expert review via an online medium such as WhatsApp, and would you be happy to be that expert? |
| cord-003532-lcgeingz | What is the role of the pulmonary embolism severity index( PESI) and RV/ LV ratio as clinical risk assessment tools for patients undergoing ultrasound- assisted catheter- directed thrombolysis( UACDT)? |
| cord-290392-kpjp0sx4 | Can we consider all the cases of acute respiratory failure associated with COVID-19 as ARDS? |
| cord-290392-kpjp0sx4 | cord-290392-kpjp0sx4 authors: Li, Xu; Ma, Xiaochun title: Acute respiratory failure in COVID-19: is it “ typical ” ARDS? |
| cord-315093-ifeulv55 | COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-315093-ifeulv55 | reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction Treatment of COVID-19 by Inhaled NO to Reduce Shunt? |
| cord-321878-bnjupaik | Different respiratory treatments for different phenotypes? |
| cord-316056-lk2upygf | COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-011875-ga0dzj3v | Are Patients with COVID-19 Dying of or with Cardiac Injury? |
| cord-011875-ga0dzj3v | Did the arrhythmia occur on a substrate of"myocardial injury,"or was this a complication of the prescribed medications( i.e., chloroquine)? |
| cord-011875-ga0dzj3v | Did these"cardiac injuries"involve patients with myocarditis? |
| cord-011875-ga0dzj3v | Furthermore, did the patients, dying of malignant arrythmia and cardiac arrest, suffer from cardiac comorbidities? |
| cord-011875-ga0dzj3v | Or were there features indicative of stress or even septic cardiomyopathy, mostly reversible entities? |
| cord-293740-4c3yemi3 | COVID-19 pneumonia: different respiratory treatment for different phenotypes? |
| cord-293740-4c3yemi3 | Early paralytic agents for ARDS? |
| cord-316923-b81uaooh | For example, in COVID-19 lung disease, a hypoxemic condition that progresses over several days in which many patients do not appear to be in distress, what is more injurious: accepting a lower oxygen saturation as measured by pulse oximetry or initiating invasive mechanical ventilation? |
| cord-316923-b81uaooh | Medical Thoracoscopy for Pleural Infection: Are We There Yet? |
| cord-324232-nupi7f72 | If the evidence favors the use of corticosteroids in nonviral ARDS, why does the WHO not recommend CST for COVID-19-associated ARDS? |
| cord-012010-5h2ox3hu | COVID-19 phenotypes: leading or misleading? |
| cord-012010-5h2ox3hu | COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-012010-5h2ox3hu | Not so Atypical Is a"Cytokine Storm"Relevant to COVID-19? |
| cord-012010-5h2ox3hu | Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design Management of COVID-19 Respiratory Distress COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted? |
| cord-012010-5h2ox3hu | cord-012010- 5h2ox3hu authors: Bos, Lieuwe D.J.; Sinha, Pratik; Dickson, Robert P. title: Response to “ COVID-19 conundrum: Clinical phenotyping based on pathophysiology as a promising approach to guide therapy in a novel illness ” and “ Strengthening the foundation of the house of CARDS by phenotyping on the fly ” and “ COVID-19 phenotypes: leading or misleading? ” |
| cord-326874-rdwvsm4s | Learn more biomedcentral.com/submissions Ready to submit your research Ready to submit your research? |
| cord-328996-3sf2i45r | COVID-19 pneumonia: different respiratory 102 treatments for different phenotypes? |
| cord-017897-mbwm0ytg | : the ABC of weaning failure-- a structured approach Is weaning failure caused by low- frequency fatigue of the diaphragm? |
| cord-017897-mbwm0ytg | Compressive forces and computed tomography- derived positive end- expiratory pressure in acute respiratory distress syndrome Recruitment maneuvers in acute respiratory distress syndrome and during general anesthesia Effects of alveolar recruitment maneuvers on clinical outcomes in patients with acute respiratory distress syndrome: a systematic review and meta- analysis Bedside ultrasound assessment of positive end- expiratory pressure- induced lung recruitment Lung stress and strain during mechanical ventilation: any safe threshold? |
| cord-017897-mbwm0ytg | Is mechanical ventilation a contributing factor? |
| cord-017897-mbwm0ytg | what is the relationship? |
| cord-005583-hmv8jjfl | Arterial oxygenation does not predict the outcome of patients with acute respiratory failure needing mechanical ventilation Is outcome from ARDS related to the severity of respiratory failure? |
| cord-005583-hmv8jjfl | Firstly, is there much to be gained by refining further the techniques of respiratory support when mortality is frequently determined by non- pulmonary factors? |
| cord-005583-hmv8jjfl | Secondly, can severity systems that solely employ acute pulmonary physiological parameters and do not incorporate underlying etiology be used to good effect, specifically in pediatric AHRF? |
| cord-005583-hmv8jjfl | Should morbidity replace mortality as an end point for clinical trials in intensive care? |
| cord-005583-hmv8jjfl | Thirdly, how can clinical trials be designed to assess the impact of new respiratory therapies? |
| cord-004532-flo9139j | A randomized trial Efficacy of adequate early antibiotic therapy in ventilator- associated pneumonia: influence of disease severity Clinical cure and survival in Gram- positive ventilator- associated pneumonia: retrospective analysis of two double- blind studies comparing linezolid with vancomycin Linezolid in VAP by MRSA: a better choice? |
| cord-004532-flo9139j | Does ICU- acquired paresis lengthen weaning from mechanical ventilation? |
| cord-004532-flo9139j | Does the patient require antibiotics? |
| cord-004532-flo9139j | The pathogenesis of catheter- related bloodstream infection with noncuffed short- term central venous catheters Watchful waiting versus immediate catheter removal in ICU patients with suspected catheter- related infection: a randomized trial Suspected central venous catheter- associated infection: can the catheter be safely retained? |
| cord-004532-flo9139j | Thus the relevant questions are: Is this patient developing VAP? |
| cord-341472-29opvzrj | Mesenchymal stem/ stromal cells( MSCs) can regulate both the innate and adaptive immune systems and can modulate macrophage phenotype, inhibit the production of inflammatory cytokines by activated CD4 and CD8 T cells, and stimulate the generation of FoxP3? |
| cord-329985-5rji08p7 | A systematic review and meta- analysis of randomized controlled trials High- Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure Lung recruitment in patients with the acute respiratory distress syndrome COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-336159-w646qkjz | The acute respiratory distress syndrome Incidence and outcomes of acute lung injury Clinical epidemiology of acute lung injury and acute respiratory distress syndrome: incidence, diagnosis, and outcomes Impact of distinct definitions of acute lung injury on its incidence and outcomes in Brazilian ICUs: prospective evaluation of 7,133 patients One- year outcomes in survivors of the acute respiratory distress syndrome Functional disability 5 years after acute respiratory distress syndrome Adult respiratory distress syndrome: a systemic overview of incidence and risk factors Incidence of the adult respiratory distress syndrome in the state of Utah Adult respiratory distress syndrome: how many cases in the UK? |
| cord-010443-4jblod8j | Are statins analogues of Vitamin D? |
| cord-010443-4jblod8j | NF- κB activation by TNF via the activation of p38 mitogen- activated protein kinase Vitamin C suppresses TNFα- induced NFκB activation by inhibiting IκBα phosphorylation Ascorbate protects against vascular leakage in cecal ligation and puncture- induced septic peritonitis Glucocorticosteroids as adjunctive therapy for acute respiratory distress syndrome and sepsis? |
| cord-010443-4jblod8j | Why do we need nongenomic glucocorticoid mechanisms? |
| cord-010443-4jblod8j | an evolutionary medicine perspective Stress- induced glucocorticoids as a neuroendocrine alarm signal of danger Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis Long- term host immune response trajectories among hospitalized patients with sepsis Protracted immune disorders at one year after ICU discharge in patients with septic shock Inflammation versus glucocorticoids as purveyors of pathology during stress: have we reached the tipping point? |
| cord-010443-4jblod8j | and decreases ROS and MCP-1 and IL-8 secretion in high- glucose exposed U937 monocytes 25-Dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells Improving the Vitamin D status of Vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle Vitamin D kinetics in the acute phase of critical illness: a prospective observational study When not to use meta- analysis: analysing the meta- analyses on Vitamin D in critical care Effect of high- dose Vitamin D3 on hospital length of stay in critically ill patients with Vitamin D deficiency: the VITdAL- ICU randomized clinical trial Is vitamin C beneficial to patients with CAP? |
| cord-286133-h8jgwe4z | Are these insights sufficient to rethink and change our practice, and if so, at which stage? |
| cord-286133-h8jgwe4z | In the meantime, how should we manage type L patients? |
| cord-286133-h8jgwe4z | why is acute respiratory distress syndrome so important for critical care? |
| cord-330640-6ityxc64 | A review Stem cell therapy: a hope business or a magic wand? |
| cord-343940-fdnmeuh8 | For study reference see Table 1 Characteristics of and important lessons from the coronavirus disease 2019( COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention Mechanical ventilation in COVID-19: interpreting the current epidemiology Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China Acute respiratory distress syndrome: the Berlin Definition COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted? |
| cord-032608-zw540s64 | : cord-032608-zw540s64 authors: Elsayed, Hany Hasan title: Dexamethasone for treatment of severe COVID-19, a surprise? |
| cord-032608-zw540s64 | If we have solid evidence that dexamethasone is beneficial for patients with established ARDS due to a variety of causes and we believe that patients with severe COVID-19 disease develop ARDS, how can we deprive five out of six arms of treatment in the RECOVERY trial who will develop COVID-19 related ARDS from steroids( or namely dexamethasone)? |
| cord-032608-zw540s64 | The question will remain: are we in a breakthrough of a new medication giving hope to millions around the world awaiting an efficient medication for COVID-19 or are we solidifying the evidence we already know about what is effective for an ARDS patient regardless of its cause? |
| cord-032608-zw540s64 | different respiratory treatments for different phenotypes? |
| cord-329381-uwae8738 | COVID-19 pneumonia: ARDS or not? |
| cord-317619-o7qfugjw | Herpes simplex virus from respiratory tract secretions: epidemiology, clinical characteristics, and outcome in immunocompromised and nonimmunocompromised hosts Life- threatening human herpes virus-6 infection in early childhood: presenting symptom of a primary immunodeficiency? |
| cord-317619-o7qfugjw | Herpes simplex virus type 1 and respiratory disease in critically- ill patients: real pathogen or innocent bystander? |
| cord-293736-nyvwv31m | : can we go from bench to bedside? |
| cord-293736-nyvwv31m | An update on immune dysregulation in obesity- related insulin resistance Adipokines and inflammation: is it a question of weight? |
| cord-293736-nyvwv31m | COVID-19 pneumonia: ARDS or not? |
| cord-334528-xenq90xj | Oleic acid inhibits alveolar fluid reabsorption: a role in acute respiratory distress syndrome? |
| cord-303101-3s9mjcf7 | : a randomised controlled trial Early deep sedation is associated with decreased in- hospital and two- year follow- up survival German recommendations for critically ill patients with COVID-19 COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-303101-3s9mjcf7 | Ist es wirklich ein akutes Lungenversagen?: |
| cord-303101-3s9mjcf7 | Lungenversagens? |
| cord-332592-bfqsyiyf | How I treat disseminated intravascular coagulation Causes of elevated Ddimer in patients admitted to a large urban emergency department Coagulopathy and antiphospholipid antibodies in patients with COVID-19 Viral hemorrhagic fever- a vascular disease? |
| cord-332592-bfqsyiyf | Will complement inhibition be the new target in treating COVID-19-related systemic thrombosis? |
| cord-286901-whvq8y1p | Could hypoxia increase the prevalence of thrombotic complications in polycythemia vera? |
| cord-286901-whvq8y1p | The science underlying COVID-19: implications for the cardiovascular system Review of D- dimer testing: good, bad, and ugly Disseminated intravascular coagulation in patients with 2019-nCoV pneumonia Acute pulmonary embolism and COVID-19 pneumonia: a random association? |
| cord-286901-whvq8y1p | The stimulation of thrombosis by hypoxia Hypoxia and inflammation More than an anticoagulant: do heparins have direct anti- inflammatory effects? |
| cord-346230-39oo7vnq | Potential therapy for COVID-19-induced ARDS? |
| cord-005573-mryrl1s1 | Can a simple lung ultrasound score predict length of ventilation for infants with severe acute viral bronchiolitis? |
| cord-005573-mryrl1s1 | Can neonatal lung ultrasound monitor fluid clearance and predict the need of respiratory support? |
| cord-005573-mryrl1s1 | Can we assess the severity of neonatal respiratory distress by ultrasound? |
| cord-005573-mryrl1s1 | The Montreux definition of neonatal ARDS: biological and clinical background behind the description of a new entity Imaging in acute respiratory distress syndrome Hospital incidence and outcomes of the acute respiratory distress syndrome using the Kigali modification of the Berlin definition Diagnosis of neonatal ARDS: is Montreux closer to Berlin than to Kigali? |
| cord-005573-mryrl1s1 | The'double lung point': an ultrasound sign diagnostic of transient tachypnea of the newborn Lung ultrasound accuracy in respiratory distress syndrome and transient tachypnea of the newborn Lung ultrasonography to diagnose transient tachypnea of the newborn Is the double lung point an accurate diagnostic marker fir transient tachypnoea of the neonate? |
| cord-339293-7ks3bopm | COVID-19, SARS and MERS: are they closely related? |
| cord-321149-hffj7s4o | Retrieval of severe acute respiratory failure patients on extracorporeal membrane oxygenation: any impact on their outcomes? |
| cord-321149-hffj7s4o | a retrospective cohort study COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-330257-fliudtls | Experts'opinion on management of 54 hemodynamics in ARDS patients: focus on the effects of mechanical ventilation Acute Respiratory Distress Syndrome Extracorporeal Membrane Oxygenation for 60 Severe Acute Respiratory Distress Syndrome and Posterior Probability of Mortality Benefit 61 in a Post Hoc Bayesian Analysis of a Randomized Clinical Trial Right Ventricular Unloading after Initiation 64 of Venovenous Extracorporeal Membrane Oxygenation Mechanical Ventilation: A Necessary Evil? |
| cord-330257-fliudtls | If the oxy- RVAD approach is rational and feasible, is it advisable? |
| cord-328569-1lx3fkv3 | , a nitric oxide donor compound Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus Inhalation of nitric oxide in the treatment of severe acute respiratory syndrome: a rescue trial in Beijing Could nasal nitric oxide help to mitigate the severity of COVID-19? |
| cord-328569-1lx3fkv3 | Care Med COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-296182-hhswage4 | All these four webinars were organized by Dr Responding to COVID-19-A once- in- acentury pandemic? |
| cord-296182-hhswage4 | Can breathing circuit filters help prevent the spread of influenza A( H1N1) virus from intubated patients? |
| cord-296182-hhswage4 | Infection and perspectives of healthcare workers Should noninvasive ventilation be considered a high- risk procedure during an epidemic? |
| cord-349201-d88g5toc | The spleen: the forgotten organ in acute kidney injury of critical illness Splenectomy exacerbates lung injury after ischemic acute kidney injury in mice Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? |
| cord-031033-v4yetn4f | How can we define"optimal microbiota?": a comparative review of structure and functions of microbiota of animals, fish, and plants in agriculture Host- microbiota interactions in immunemediated diseases Genomic approaches to studying the human microbiota Defining dysbiosis and its influence on host immunity and disease |
| cord-031033-v4yetn4f | How did these bacteria get there? |
| cord-031033-v4yetn4f | How to study the lung microbiome? |
| cord-031033-v4yetn4f | So, the more appropriate question is'do patients that develop pneumonia have more dysbiosis of the lung microbiome than mechanically ventilated ICU patients who do not develop pneumonia'? |
| cord-031033-v4yetn4f | What is the healthy gut microbiota composition? |
| cord-330919-dep3v1pt | A Case Series Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism Tissue plasminogen activator( tPA) inhibits interleukin-1 induced acute lung leak Heuze- Vourc'h N. Designing inhaled protein therapeutics for topical lung delivery: what are the next steps? |
| cord-330919-dep3v1pt | The acute respiratory distress syndrome Tissue Plasminogen Activator( tPA) as a Novel Treatment for Refractory COVID-19 Associated Acute Respiratory Distress Syndrome( ARDS)? |
| cord-331500-l3hkn2li | Host- pathogen interaction during mechanical ventilation: systemic or compartmentalized response? |
| cord-331500-l3hkn2li | How can we distinguish ventilator- associated tracheobronchitis from pneumonia? |
| cord-352365-b9cmviny | a case report Complete resolution of life- threatening bleomycin- induced pneumonitis after treatment with imatinib mesylate in a patient with Hodgkin's lymphoma: hope for severe chemotherapy- induced toxicity? |
| cord-349329-f0pbd968 | a postinfluenza pneumococcal pneumonia model Lung epithelial GM- CSF improves host defense function and epithelial repair in influenza virus pneumonia- a new therapeutic strategy? |
| cord-290460-d5e6y2r8 | : qualitative, quantitative and mixed methods approaches The quality of mixed methods studies in health services research Standards for reporting qualitative research: a synthesis of recommendations Driving pressure is not associated with mortality in mechanically ventilated patients without ARDS Scoping studies: towards a methodological framework Scoping studies: advancing the methodology Guidance for conducting systematic scoping reviews Systematic review or scoping review? |
| cord-290460-d5e6y2r8 | What is an adequate sample size? |
| cord-290460-d5e6y2r8 | Why do n't physicians follow clinical practice guidelines? |
| cord-355208-hpldjsc5 | COVID-19 pneumonia: different respiratory treatment for different phenotypes? |
| cord-276927-rxudwp2v | Combination of high frequency oscillatory ventilation and interventional lung assist in severe acute respiratory distress syndrome Clinical characteristics and outcomes of sepsis- related vs non- sepsis- related ARDS Virus- induced acute respiratory distress syndrome: epidemiology, management and outcome Biomarkers of acute lung injury: worth their salt? |
| cord-276927-rxudwp2v | Does noninvasive positive pressure ventilation improve outcome in acute hypoxemic respiratory failure? |
| cord-276927-rxudwp2v | The acute respiratory distress syndrome ARDS and diffuse alveolar damage: a pathologist's perspective Clinical year in review III: asthma, lung transplantation, cystic fibrosis, acute respiratory distress syndrome Performance of an automated electronic acute lung injury screening system in intensive care unit patients Introducing automated acute lung injury/ acute respiratory distress syndrome electronic screening in intensive care unit practice: is it the future? |
| cord-276927-rxudwp2v | What has computed tomography taught us about the acute respiratory distress syndrome? |
| cord-276927-rxudwp2v | and what do we need to get there? |
| cord-349440-jxigsdzh | COVID-19 phenotypes: leading or misleading? |
| cord-349440-jxigsdzh | The perils of premature phenotyping in COVID: a call for caution COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-353594-z1vxamvp | COVID-19: risk for cytokine targeting in chronic inflammatory diseases? |
| cord-353594-z1vxamvp | PR3 and MPO antigen microdots improve the laboratory diagnostics of ANCA- associated vasculitis From ANA to ENA: how to proceed? |
| cord-310069-ay4af6xr | Do we need ARDS? |
| cord-310069-ay4af6xr | The question"Do patients with COVID-19 develop typical ARDS? |
| cord-310069-ay4af6xr | What exactly is ARDS, and how should a doctor decide whether some patient has ARDS or another disorder? |
| cord-310069-ay4af6xr | authors: Tobin, Martin J. title: Does making a diagnosis of ARDS in COVID-19 patients matter? |
| cord-015126-cyhcbk1j | Can the regional cerebral oximetry helps us to determine individual adequate blood pressure? |
| cord-015126-cyhcbk1j | Can we achieve desired therapeutic goal in treatment of respiratory failure( RF) with this very simple, non- invasive method? |
| cord-015126-cyhcbk1j | Does diabetes mellitus matter? |
| cord-015126-cyhcbk1j | L patients died, however, hospital mortality rate was 53.8? |
| cord-015126-cyhcbk1j | Several statistical tests by the use of SPSS made it possible to analyse and answer the research question: Are children who only get long- term opioids in the initial anaesthetic phase( B) of the operation more agitated than those who where also given a refill of long- term opioids( A)? |
| cord-015126-cyhcbk1j | Table:% of positive response for each item("would you like information on this topic in an ICU booklet?") grouped into categories. |
| cord-335975-m6lkrehi | Could ICU to ward transfers and care course after hospital be optimized? |
| cord-335975-m6lkrehi | Pharmacokinetic analysis of unfractionated heparin in critically ill children during extracorporeal membrane oxygenation: Do we achieve the target? |
| cord-316647-jj8anf5g | Does pulse pressure variation predict fluid responsiveness in critically ill patients? |
| cord-316647-jj8anf5g | The convalescent sera option for containing COVID-19 Meta- analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? |
| cord-316647-jj8anf5g | Use of convalescent plasma therapy in SARS patients in Hong Kong Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A( H1N1) 2009 virus infection Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience Treatment of 5 critically ill patients with COVID-19 with convalescent plasma Effectiveness of convalescent plasma therapy in severe COVID-19 patients Convalescent plasma: new evidence for an old therapeutic tool? |
| cord-316647-jj8anf5g | a study on coronary artery bypass graft surgery patients Monitoring sound and light continuously in an intensive care unit patient room: a pilot study The efficacy of earplugs as a sleep hygiene strategy for reducing delirium in the ICU: a systematic review and meta- analysis Effect of dexmedetomidine added to standard care on ventilatorfree time in patients with agitated delirium: a randomized clinical trial Melatonin decreases delirium in elderly patients: a randomized, placebo- controlled trial Preventive effects of ramelteon on delirium: a randomized placebo- controlled trial Melatonin, ramelteon, suvorexant, and dexmedetomidine to promote sleep and prevent delirium in critically ill patients: a narrative review with practical applications Interpreting and implementing the 2018 pain, agitation/ sedation, delirium, immobility, and sleep disruption clinical practice guideline Sedation with sufentanil in patients receiving pressure support ventilation has no effects on respiration: a pilot study Could remifentanil reduce duration of mechanical ventilation in comparison with other opioids for mechanically ventilated patients? |
| cord-005777-6rvfsx4p | CAN PROTEIN S100 PREDICT NEUROLOGICAL DETERIORATION AFTER MODERATE OR MINOR TRAUMATIC BRAIN INJURY? |
| cord-005777-6rvfsx4p | Is it not our rescuer? |
| cord-005777-6rvfsx4p | The APACHE? |
| cord-005777-6rvfsx4p | What is the impact of newly diagnosed AF on mortality and length of ICU stay in patients with septic shock? |
| cord-005777-6rvfsx4p | What is the incidence of newly diagnosed AF on a surgical intensive care unit( ICU)? |
| cord-005777-6rvfsx4p | Which percentage of patients suffering a septic shock eventually does develop AF? |
| cord-335977-f00758o2 | Do glucocorticoids decrease mortality in acute respiratory distress syndrome? |
| cord-335977-f00758o2 | Interferon- mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome Fatal outcome of human influenza A( H5N1) is associated with high viral load and hypercytokinemia Glucocorticoid in the treatment of severe acute respiratory syndrome patients: a preliminary report Coronavirus- positive nasopharyngeal aspirate as predictor for severe acute respiratory syndrome mortality Effects of early corticosteroid treatment on plasma SARS- associated Coronavirus RNA concentrations in adult patients Hydrocortisone therapy for patients with septic shock Organ dysfunction/ failure in patients with septic shock: results of the CORTICUS study Compartmentalized cytokine production within the human lung in unilateral pneumonia Effects of systemic steroids in patients with severe community- acquired pneumonia Guidelines for the management of adults with hospital- acquired, ventilator- associated, and healthcareassociated pneumonia Bench- to- bedside review: appropriate antibiotic therapy in severe sepsis and septic shock- does the dose matter? |
| cord-335977-f00758o2 | influenza A( H1N1) virus infection Corticosteroids for H1N1 associated acute lung injury: is it just wishful thinking? |
| cord-293259-o51fnvuw | : what is"immunosenescence Immunosenescence and inflamm- aging as two sides of the same coin: friends or foes? |
| cord-293259-o51fnvuw | COVID-19: the gendered impacts of the outbreak Will children reveal their secret? |
| cord-293259-o51fnvuw | Possible vertical transmission of SARS- CoV-2 from an infected mother to her newborn Antibodies in infants born to mothers with COVID-19 pneumonia Neonatal early- onset infection with SARS- CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan Is it Kawasaki shock syndrome, Kawasaki- like disease or pediatric inflammatory multisystem disease? |
| cord-293259-o51fnvuw | The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases( COVID-19)-China Coronavirus disease 2019( COVID-19) in Italy Clinical and epidemiological features of 36 children with coronavirus disease 2019( COVID-19) in Zhejiang, China: an observational cohort study Are children less susceptible to COVID-19? |
| cord-293259-o51fnvuw | Why some children experience more severe illness? |
| cord-303292-iheq50ub | How can I manage anaesthesia in obese patients? |
| cord-303292-iheq50ub | How important is obesity as a risk factor for respiratory failure, intensive care admission and death in hospitalised COVID-19 patients? |
| cord-303292-iheq50ub | Is body mass index associated with outcomes of mechanically ventilated adult patients in intensive critical units? |
| cord-303292-iheq50ub | The effects of body mass on lung volumes, respiratory mechanics, and gas exchange during general anesthesia Airway closure during surgical pneumoperitoneum in obese patients Airway closure, more harmful than atelectasis in intensive care? |
| cord-338319-9v8yw2pl | COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted? |
| cord-338319-9v8yw2pl | How severe COVID-19 infection is changing ARDS management Angiotensin- converting enzyme 2( ACE2) as a SARS- CoV-2 receptor: molecular mechanisms and potential therapeutic target Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19 Management of COVID-19 respiratory distress COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-338319-9v8yw2pl | What have we learned ventilating COVID-19 patients? |
| cord-333520-v2sb90rc | : Is there enough evidence? |
| cord-333520-v2sb90rc | Could Mesenchymal Stem Cell- Derived Exosomes Be a Therapeutic Option for Critically Ill COVID-19 Patients? |
| cord-333520-v2sb90rc | Do Angiotensin- Converting Enzyme Inhibitors/ Angiotensin Receptor Blockers Have a Biphasic Effect? |
| cord-325408-uy5ew3ki | Is our policy of waiting for proof of benefit before instituting novel therapeutics still sensible? |
| cord-325408-uy5ew3ki | Specifically, do mechanical ventilation strategies optimized in ARDS trials still apply to this disease? |
| cord-325408-uy5ew3ki | Why are physicians abandoning standards of critical care in the era of COVID-19? |
| cord-325408-uy5ew3ki | different respiratory treatments for different phenotypes? |
| cord-352065-960xqft4 | : Who Will Live and Who Will Die? |
| cord-352065-960xqft4 | Severe COVID-19 and healthcare- associated infections on the ICU: time to remember the basics? |
| cord-352065-960xqft4 | The epidemiology and clinical information about COVID-19 Estimates of the severity of coronavirus disease 2019: a model- based analysis Bacterial and fungal co- infection in individuals with coronavirus: A rapid review to support COVID-19 antimicrobial prescribing Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times? |
| cord-323566-jck799zq | : A. Refers to an increased number of alveoli relative to the corresponding conducting airways Which of the following is NOT in the macroscopic differential diagnosis of cystic lung lesions in children? |
| cord-323566-jck799zq | Extralobar pulmonary sequestrations may occasionally contain which ONE of the following heterotopic tissues? |
| cord-323566-jck799zq | One of the first questions to be addressed is whether or not a known inciting event was identified clinically( i.e., Is this ARDS?). |
| cord-323566-jck799zq | Which ONE of the following storage disorders does NOT usually involve the lung parenchyma? |
| cord-323566-jck799zq | Which ONE of the following tissues may have implications for future lung pathology, if it is present in a congenital malformation of the pulmonary airways? |
| cord-343743-6k3soh1l | COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-343743-6k3soh1l | Canadian critical care trials, functional disability 5 years after acute respiratory distress syndrome Pulmonary fibrosis secondary to COVID-19: a call to arms? |
| cord-343743-6k3soh1l | However, we find ourselves asking: Is it worth spending valuable time, resources, and scientific energy studying anti- fibrotic therapies in acutely ill, consent- weary patients that truly need a targeted antiviral treatment or trial? |
| cord-343743-6k3soh1l | Pseudoscience and COVID-19-we've had enough already COVID-19 lung injury and high altitude pulmonary edema: a false equation with dangerous implications Chloroquine for influenza prevention: a randomised, double- blind, placebo controlled trial Observational study of hydroxychloroquine in hospitalized patients with Covid-19 A randomized trial of hydroxychloroquine as postexposure prophylaxis for Covid-19 The role of epidermal growth factor receptor( EGFR) signaling in SARS coronavirus- induced pulmonary fibrosis Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy Long- term outcome after the acute respiratory distress syndrome: different from general critical illness? |
| cord-333856-ujnhjy0s | A resolution for acute respiratory distress syndrome? |
| cord-333856-ujnhjy0s | The acute respiratory distress syndrome Inflammation and immunity in IPF pathogenesis and treatment Pulmonary surfactant: functions and molecular composition New insights into exogenous surfactant as a carrier of pulmonary therapeutics Current perspectives in pulmonary surfactant- inhibition, enhancement and evaluation Surfactants: past, present and future Exogenous surfactant therapy in 2013: what is next? |
| cord-333856-ujnhjy0s | The mercurial nature of neutrophils: still an enigma in ARDS? |
| cord-333856-ujnhjy0s | Who, when and how should we treat newborn infants in the future? |
| cord-309089-ex9nh1yi | The mercurial nature of neutrophils: still an enigma in ARDS? |
| cord-309089-ex9nh1yi | What does the peripheral blood tell you in SARS? |
| cord-309089-ex9nh1yi | a meta- analysis Interleukin-6 as a potential biomarker of COVID-19 progression Inhibition of NF- κB- mediated inflammation in severe acute respiratory syndrome coronavirus- infected mice increases survival Role of chemokines in thyroid cancermicroenvironment: is CXCL8 the main player? |
| cord-309089-ex9nh1yi | antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/ Golgi membrane Severe acute respiratory syndrome coronavirus open reading frame( ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists One nucleotide in a kappaB site can determine cofactor specificity for NF- kappaB dimers Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus SARS coronavirus and innate immunity Inhibition of cytokine gene expression and induction of chemokine genes in nonlymphatic cells infected with SARS coronavirus Activation of AP-1 signal transduction pathway by SARS coronavirus nucleocapsid protein Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection Distinct immune response in two MERS- CoVinfected patients: can we go from bench to bedside? |
| cord-309089-ex9nh1yi | do you draw the line? |
| cord-005646-xhx9pzhj | Can HFO ce considered standard, not experimental method of therapy? |
| cord-005646-xhx9pzhj | K deficiency in earl? |
| cord-005646-xhx9pzhj | Speculation: Should not HFO be used ir pediatric patients with ARDS earlier than aggressive CMV? |
| cord-005646-xhx9pzhj | The thesis of the questionnaire was: Does the ICU syndrome occur in critical ill children in the age between three and ten, who have been intubated and/or ventilated in a PICU? |
| cord-005646-xhx9pzhj | Thunnissen t, Reinoud J.B.J. Gemke 1, Loes Veenhuizer?, Krijn Haasnoot 3, A.Johannes van Vugh0 Department of pediatrics,~Wilhelmina |
| cord-005646-xhx9pzhj | an influence of nasal mask ventilation on the REE?3.What is the nutritional state?4.What is the estimated total energy expenditure(ETE) in relation to the caloric intake? |
| cord-005646-xhx9pzhj | ~tttdy at"Ihe stale~f hematocr~ chcplm/ itic bm~ ic~ in ckil&en with 31110oN emergensy is of abviou.~!? |
| cord-345028-56hg62be | : armin.flinspach@kgu.de Sedation of mechanically ventilated COVID-19 patients: Challenges and special considerations Sevoflurane, a sigh of relief in COVID-19? |
| cord-345028-56hg62be | Different respiratory treatments for different phenotypes? |
| cord-345028-56hg62be | Is a new player emerging in critical care sedation? |
| cord-345028-56hg62be | Which specificities? |
| cord-005910-byffqwjd | Verglichen mit was? |
| cord-005910-byffqwjd | Wäre ein Vergleich mit druckkontrollierter Beatmung nicht sinnvoller?"Das ist nicht nötig. cord-005910-byffqwjd A new approach to teaching the practice of medicine Evidence based medicine: a movement in crisis Too much guidance? cord-005910-byffqwjd Und übrigens, wie würden Sie eine Anämie behandeln? cord-005910-byffqwjd War das nicht die Studie, in der uraltes Blut transfundiert wurde? |
| cord-005910-byffqwjd | What have we learned since NICE- SUGAR? |
| cord-005910-byffqwjd | auf der Seite zu lagern? |
| cord-005910-byffqwjd | ihm Spontanatmung zu ermöglichen?" |
| cord-005910-byffqwjd | sequential analysis Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a noncardiac surgery setting: systematic review and meta- analysis Fresh versus old red cell transfusions: What have the recent clinical trials found? |
| cord-014464-m5n250r2 | 10 Questions to Help You Make Sense of Qualitative Research Quality measurement at intensive care units: which indicators should we use? |
| cord-014464-m5n250r2 | An Acute Problem? |
| cord-014464-m5n250r2 | As TEG measures the thrombodynamic properties of whole blood coagulation, perhaps it is a more reliable indicator of heparin activity? |
| cord-014464-m5n250r2 | Both hypoxemia and extreme hyperoxemia may be detrimental in patients with severe traumatic brain injury Focused assessment with sonography in trauma( FAST): should its role be reconsidered? |
| cord-014464-m5n250r2 | Early prognosis in traumatic brain injury: from prophecies to predictions One- year extended Glasgow Outcome Scale and hospital mortality predictors in patients with severe traumatic brain injury in Brazil R Turon 1, FR Ferreira 1, D Prado 1 Bioavailability of subcutaneous low- molecular- weight heparin to patients on vasopressors Prophylactic anticoagulation with enoxaparin: is the subcoutaneous route appropriate in the critically ill? |
| cord-014464-m5n250r2 | Introduction Are safety guidelines being followed when administering procedural sedation in the emergency department? |
| cord-014464-m5n250r2 | Overcrowding estimation in the emergency department: is the simplest score the best? |
| cord-014538-6a2pviol | ( 2) to what extent does this relationship impact their experience of ICU? |
| cord-014538-6a2pviol | 6 Réanimation Médicale An audit of intensive care unit recyclable waste S77 Point of care ultrasonography: is there a place for pocket size ultrasonography devices? |
| cord-014538-6a2pviol | Formalisées d'Experts « Prise en charge des infections intra- abdominales Strategies to reduce curative antibiotic therapy in intensive care units( adult and paediatric) Risk factors for developing ESBL E. coli: can clinicians predict infection in patients with prior colonization? |
| cord-014538-6a2pviol | Quand y penser-quoi faire Outcomes of early decompressive craniectomy versus conventional medical management after severe traumatic brain injury: a systematic review and meta- analysis Myocardial dysfunction evaluation in pediatric brain death donor Service de régulation et d'appui, Agence biomedecine Prone position for acute respiratory failure in adults Prone positioning in severe acute respiratory distress syndrome Effects of the prone position on respiratory mechanics and gas exchange during acute lung injury Does prone positioning increase intracranial pressure? |
| cord-014538-6a2pviol | Specifically, our research questions were, with regards to the letters'content,( 1) how is the caring relationship tackled and characterized by relatives? |
| cord-014538-6a2pviol | Where should we place the stethoscope's chestpiece to hear the noise of the primary bronchi? |
| cord-014538-6a2pviol | analysis of 5263 patients using a national inpatient database in Japan Is the 77.1% rate of in- hospital mortality in patients receiving venoarterial extracorporeal membrane oxygenation really that high? |
| cord-014538-6a2pviol | answers from the microcirculation? |
| cord-014538-6a2pviol | what finding? |
| cord-344829-adlp2rjy | ( COVID-19) affect the eyes? |
| cord-344829-adlp2rjy | : a therapeutic target in severe pulmonary inflammation including COVID-19? |
| cord-344829-adlp2rjy | COVID-19: consider cytokine storm syndromes and immunosuppression Clinical features of patients infected with 2019 novel coronavirus in Wuhan Is a"Cytokine Storm"relevant to COVID-19? |
| cord-344829-adlp2rjy | inflammasome signaling promotes atrial fibrillation Increased serum levels of interleukin-1beta in the systemic circulation of patients with essential hypertension: additional risk factor for atherogenesis in hypertensive patients? |
| cord-344829-adlp2rjy | severe acute respiratory syndrome SARS- CoV-2 infects human neural progenitor cells and brain organoids Extracellular vesicles and viruses: are they close relatives? |
| cord-015024-2xzc0uc5 | Does chest physical therapy work? |
| cord-015024-2xzc0uc5 | IN TERMS OF IMPROVING LUNG FUNCTION? |
| cord-015024-2xzc0uc5 | Intraoperative fluid restriction improves outcome after major elective gastrointestinal surgery SURROGATE DESIGNATION: CAN WE TRUST OUR RELATIVES? |
| cord-015024-2xzc0uc5 | The development and evaluation of an incident reporting system in intensive care Adverse events in critical ill patients Ministry of Health and Social Policy 1254 COMMUNICATION: A KEY FACTOR IN THE PATIENT SAFETY? |
| cord-015024-2xzc0uc5 | There was however a clear decrease in serum ferritin levels from 162 ± 48 at baseline to 109? |
| cord-015024-2xzc0uc5 | To the staff of the critical care department, faculty of medicine Injury severity and quality of life: whose perspective is important? |
| cord-015024-2xzc0uc5 | sodium bicarbonatein treting lactic acidosis from shock? |
| cord-014533-6qfecv5h | A 6 yr prospective evaluation of the single tapered dilator technique Can outcomes of intensive care unit patients undergoing tracheostomy be predicted? |
| cord-014533-6qfecv5h | A Quality Finish? |
| cord-014533-6qfecv5h | Associated With Chronic Opioid Use? |
| cord-014533-6qfecv5h | Combined ICU multi- disciplinary handover rounds with the lead consultant asking the question"Can this patient be mobilised?"for every patient reviewed. |
| cord-014533-6qfecv5h | Crit Care Are the dysnatremias a permanent threat to the critically ill patient? |
| cord-014533-6qfecv5h | The impact of organ dysfunction in cirrhosis: survival at a cost? |
| cord-014533-6qfecv5h | What Do Recent Studies Tell Us? |
| cord-014533-6qfecv5h | a case series Outcomes and cost of cardiac surgery in octogenarians is related to type of operation: a multiinstitutional analysis Aortic valve replacement with and without coronary artery bypass graft surgery in octogenarians: is it safe and feasible? |
| cord-014533-6qfecv5h | cuff pressure control: does the CO2 matter? |
| cord-328396-p2gvpe8i | A meta- analysis Neutrophilto- lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19 COVID- ARDS clarified: a vascular endotype? |
| cord-328396-p2gvpe8i | COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-328396-p2gvpe8i | The endothelium in hypoxic pulmonary vasoconstriction Is the reason of increased D- dimer levels in COVID-19 because of ACE-2-induced apoptosis in endothelium? |
| cord-328396-p2gvpe8i | The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome Hypertension, thrombosis, kidney failure, and diabetes: is COVID-19 an endothelial disease? |
| cord-328396-p2gvpe8i | a comprehensive evaluation of clinical and basic evidence Is COVID-19 an endothelial disease? |
| cord-328396-p2gvpe8i | related coagulopathy: a distinct entity? |
| cord-324296-a9as72bx | A randomized prospective study ECMO for ARDS: from salvage to standard of care? |
| cord-324296-a9as72bx | As stated in the editorial addressing the Bayesian analysis, it is no longer a question of"Does ECMO work? |
| cord-324296-a9as72bx | Extracorporeal membrane oxygenation for 2009 influenza A( H1N1) acute respiratory distress syndrome Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure( CESAR): a multicentre randomised controlled trial Learning from a trial stopped by a data and safety monitoring board Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome and posterior probability of mortality benefit in a post hoc bayesian analysis of a randomized clinical trial ECMO for severe ARDS: systematic review and individual patient data meta- analysis Venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta- analysis Time for clinicians to embrace their inner bayesian?: |
| cord-324296-a9as72bx | No Should patients with acute respiratory distress syndrome on venovenous extracorporeal membrane oxygenation have ventilatory support reduced to the lowest tolerable settings? |
| cord-324296-a9as72bx | The major question now is rather:"How to provide better ECMO care?". |
| cord-324296-a9as72bx | Understanding hypoxemia on ECCO2R: back to the alveolar gas equation Should patients with acute respiratory distress syndrome on venovenous extracorporeal membrane oxygenation have ventilatory support reduced to the lowest tolerable settings? |
| cord-324296-a9as72bx | because that question appears to be answered but by how much does ECMO work, in whom, and at what cost? |
| cord-324296-a9as72bx | simple- the case of extracorporeal devices in critical care Extracorporeal gas exchange: when to start and how to end? |
| cord-355038-o2hr5mox | , and practice changes: echo guidance, antibiotic prophylaxis or locks? |
| cord-355038-o2hr5mox | Second generation catheters? |
| cord-355038-o2hr5mox | To remedy this requires the implementation of additional hygiene measures: antiseptic showers preoperatively, Chlorhexidine?? |
| cord-355038-o2hr5mox | To remedy this requires the implementation of additional hygiene measures: antiseptic showers preoperatively, Chlorhexidine?? |
| cord-355038-o2hr5mox | a possibility for a fast and safe way to deliver treatments in the delivery room? |
| cord-355038-o2hr5mox | can citrate be avoided using citrate- and calcium- free dialysate( CCF- IHD)? |
| cord-286771-77hs34jm | Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study Mechanisms of atelectasis in the peri- operative period Reabsorption atelectasis in a porcine model of ARDS: regional and temporal effects of airway closure, oxygen, and distending pressure Lung stress and strain during mechanical ventilation: any difference between statics and dynamics? |
| cord-286771-77hs34jm | COVID-19 pneumonia: ARDS or not? |
| cord-286771-77hs34jm | Can high- flow nasal cannula reduce the rate of endotracheal intubation in adult patients with acute respiratory failure compared with conventional oxygen therapy and noninvasive positive pressure ventilation? |
| cord-286771-77hs34jm | Given the fact that regional strain and heterogeneity are present during a normal respiratory cycle without harming the lung leads to the question: why P- SILI does not develop in normal lungs deformed by physiologic Vt? |
| cord-286771-77hs34jm | Severe Covid-19 disease: rather AVDS than ARDS? |
| cord-286771-77hs34jm | The link between regional tidal stretch and lung injury during mechanical ventilation Deterioration of regional lung strain and inflammation during early lung injury Mechanotransduction in the lungs Towards prevention of ventilatorinduced lung injury: is mechanotransduction the answer? |
| cord-286771-77hs34jm | The role of three- dimensionality and alveolar pressure in the distribution and amplification of alveolar stresses Does regional lung strain correlate with regional inflammation in acute respiratory distress syndrome during nonprotective ventilation? |
| cord-286771-77hs34jm | Ventilation- induced lung injury exists in spontaneously breathing patients with acute respiratory failure: yes Spontaneous breathing in early acute respiratory distress syndrome: insights from the large observational study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study Balancing forces: architectural control of mechanotransduction Lung stress and strain during mechanical ventilation: any safe threshold? |
| cord-286771-77hs34jm | When to promote spontaneous respiratory activity in acute respiratory distress patients? |
| cord-286771-77hs34jm | a multicenter cohort study Clinical practice and risk factors for immediate complications of endotracheal intubation in the intensive care unit: a prospective, multiple- center study COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-318209-llucxztc | Effects of intratracheal mesenchymal stromal cell therapy during recovery and resolution after ventilatorinduced lung injury Intravenous mesenchymal stem cell therapy for traumatic brain injury Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first- pass effect Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting Translational applications of tissue engineering in cardiovascular medicine Extracellular matrix and regenerative therapies from the cardiac perspective Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke( MASTERS): a randomised, double- blind, placebo- controlled, phase 2 trial Strategies for improving animal models for regenerative medicine Can animal models of disease reliably inform human studies? |
| cord-318209-llucxztc | MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines Extracellular vesicles or exosomes? |
| cord-318209-llucxztc | Mesenchymal stem cell infusion shows promise for combating coronavirus( COVID-19)-induced pneumonia Mesenchymal stromal cell secretome for severe COVID-19 infections: premises for the therapeutic use Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia Mesenchymal stem cells for coronavirus( COVID-19)-induced pneumonia: revisiting the paracrine hypothesis with new hopes? |
| cord-318209-llucxztc | Nonventilatory treatments for acute lung injury and ARDS Clinical review: Stem cell therapies for acute lung injury/ acute respiratory distress syndrome-hope or hype? |
| cord-318209-llucxztc | Possible role of exosomes containing RNA in mediating nontargeted effect of ionizing radiation Extracellular vesicles mediate radiationinduced systemic bystander signals in the bone marrow and spleen Endometrial regenerative cells and exosomes thereof for treatment of radiation exposure Cranial grafting of stem cellderived microvesicles improves cognition and reduces neuropathology in the irradiated brain Macrophages educated with exosomes from primed mesenchymal stem cells treat acute radiation syndrome by promoting hematopoietic recovery Initial evaluation and management of the critical burn patient Burn support for Operation Iraqi Freedom and related operations Stem cells in skin regeneration, wound healing, and their clinical applications Stem cell therapy: a new treatment for burns? |
| cord-318209-llucxztc | Systemic immune response to traumatic cns injuries- are extracellular vesicles the missing link? |
| cord-318209-llucxztc | The challenge of bringing iPSCs to the patient One, two, three steps toward cell therapy for stroke Concise review: stem cell therapy for stroke patients: are we there yet? |
| cord-318209-llucxztc | mesenchymal stromal/ stem cells: a new treatment for sepsis and septic shock? |
| cord-318209-llucxztc | progress and challenges Trends in mesenchymal stem cell clinical trials 2004- 2018: is efficacy optimal in a narrow dose range? |
| cord-341063-3rqnu5bu | -If not currently using has it been considered? |
| cord-341063-3rqnu5bu | -Which antibiotics are you using for continuous or extended infusions? |
| cord-341063-3rqnu5bu | Is enzymatic debridement better in critically burned patients? |
| cord-341063-3rqnu5bu | P441 Acquired neuromuscular weakness in eldery patients with femoral bone fracture, could we decrease the incidence? |
| cord-341063-3rqnu5bu | Questions included:-Are you using continuous or extended antibiotic infusions? |
| cord-341063-3rqnu5bu | Using a protocol for fluid resuscitation: how well is it followed? |
| cord-341063-3rqnu5bu | What are physicians in doubt about? |
| cord-341063-3rqnu5bu | is it still required? |
| cord-325461-q8igdvq4 | 13: the pulmonary circulation and right ventricular failure in the ITU Is there a safe plateau pressure in ARDS? |
| cord-325461-q8igdvq4 | A meaningless variable? |
| cord-325461-q8igdvq4 | Is PVD a marker of the severity of ARDS? |
| cord-325461-q8igdvq4 | Is pulmonary hypertension simply an indicator of the severity of lung injury or is it part of the underlying pathophysiological process contributing to the development of ARDS? |
| cord-325461-q8igdvq4 | Is the same true for patients with ARDS? |
| cord-325461-q8igdvq4 | Vascular endothelial growth factor( VEGF) in acute lung injury( ALI) and acute respiratory distress syndrome( ARDS): paradox or paradigm? |
| cord-325461-q8igdvq4 | Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome Incidence and outcomes of acute lung injury Has mortality from acute respiratory distress syndrome decreased over time? |
| cord-325461-q8igdvq4 | What might account for these differences? |
| cord-325461-q8igdvq4 | Why do the studies of pulmonary haemodynamics report inconsistent relationships with mortality? |
| cord-325461-q8igdvq4 | Why protect the right ventricle in patients with acute respiratory distress syndrome? |
| cord-282547-ehr9aaix | Also, what is the role of the platelet in coagulation cascade? |
| cord-282547-ehr9aaix | Disseminated intravascular coagulation: is it fact or fancy? |
| cord-282547-ehr9aaix | For example, what is the role of von Willebrand factor( VWF) in the thrombogenesis and coagulation? |
| cord-282547-ehr9aaix | How do we approach thrombocytopenia in critically ill patients? |
| cord-282547-ehr9aaix | Randomized, placebo- controlled clinical trial of an aerosolized b 2-agonist for treatment of acute lung injury Steroids for acute respiratory distress syndrome? |
| cord-282547-ehr9aaix | Sepsis- induced disseminated intravascular coagulation with features of thrombotic thrombocytopenic purpura: a fatal fulminant syndrome Disseminated intravascular coagulation and thrombotic thrombocytopenic purpura/ hemolytic uremic syndrome Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies- what intensivists need to know Thrombotic thrombocytopenic purpura or disseminated intravascular coagulation? |
| cord-282547-ehr9aaix | Targeting neutrophil extracellular traps in acute lung injury: a novel therapeutic approach in acute respiratory distress syndrome? |
| cord-282547-ehr9aaix | What is coagulation? |
| cord-282547-ehr9aaix | What is the difference between fibrin clots of activated TF path and thrombosis of deep vein thrombosis( DVT)? |
| cord-282547-ehr9aaix | What is the difference between microthrombi and macrothrombus? |
| cord-282547-ehr9aaix | Why do patients who have acute lung injury/ acute respiratory distress syndrome die from multiple organ dysfunction syndrome? |
| cord-282547-ehr9aaix | Why is it? |
| cord-282547-ehr9aaix | Why is microthrombosis disseminated, but is DVT localized? |
| cord-282547-ehr9aaix | and how is it different from thrombogenesis? |
| cord-282547-ehr9aaix | vascular microthrombotic disease A thought on possible pathogenesis of Ebola viral hemorrhagic disease and potential treatments: could it be thrombotic thrombocytopenic purpura- like syndrome? |
| cord-321499-17n9tj70 | Abrupt deterioration often occurs after days of smoldering infection Do symptomatic patients who present with severe hypoxemia sort into"L and H"phenotypes? |
| cord-321499-17n9tj70 | Can we develop an effective vaccine against variants of COVID and distribute it worldwide? |
| cord-321499-17n9tj70 | Children are affected less often and usually less severely than adults, yet may have rare post- infectious complications related to previous vascular invasion Are there different COVID-19 genetic types and virulence, perhaps due to its RNA mutations? |
| cord-321499-17n9tj70 | Do patients progress to diffuse airspace disease via patient self- inflicted lung injury( PSILI)? |
| cord-321499-17n9tj70 | Does the fact that CARDS patients meet the Berlin definition mean that these patients will respond to standard approaches and guidelines for ARDS? |
| cord-321499-17n9tj70 | Early CT infiltrates occurring in severely hypoxemic patients are often scant, peripheral, and characterized by atypical'ground glass'or'crazy paving'Does disrupted vasoregulation with minor shunt explain the severity of early hypoxemia? |
| cord-321499-17n9tj70 | For example, we argue: Does intense, sepsis- like cytokine release drive shock? |
| cord-321499-17n9tj70 | How long will such a vaccine be effective? |
| cord-321499-17n9tj70 | Prone positioning and PEEP improve PaO 2/FiO 2 Should full anticoagulation be routinely implemented? |
| cord-321499-17n9tj70 | Respiratory failure often resolves slowly in the most severely ill who do survive Which available drugs and proposed anti- viral approaches for COVID-19 treatment hold the most potential for benefit or risk? |
| cord-321499-17n9tj70 | Should we manage CARDS as routine ARDS? |
| cord-321499-17n9tj70 | So- called'silent hypoxemia'may precede overt respiratory distress Are there inflammatory versus non- inflammatory phenotypes of CARDS? |
| cord-321499-17n9tj70 | The perils of premature phenotyping in COVID: a call for caution COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-321499-17n9tj70 | Unusually high minute ventilation and high dead space may be evident from the outset What role does'cytokine storm'play in the clinical presentations of COVID-19? |
| cord-321499-17n9tj70 | What explains highly variable mortality rates, site- to- site? |
| cord-321499-17n9tj70 | What explains striking geographic differences of incidence? |
| cord-321499-17n9tj70 | the Berlin Definition Reclassifying acute respiratory distress syndrome Do the NIH ARDS Clinical Trials network PEEP/ FiO 2 tables provide the best evidence- based guide to balancing PEEP and FiO 2 settings in adults? |
| cord-005705-j765ruj1 | -Clinical trials should be appraised according to the ethical principle of distributive justice: what cost for what result? |
| cord-005705-j765ruj1 | Are we really reducing tidal volume- and should we? |
| cord-005705-j765ruj1 | As mentioned above, what makes the greatest contribution to clinical practice regarding the prevention of gastrointestinal bleeding in ICU patients:"discordant"metaanalyses of multiple RCTs[ 45, 46] or a well conducted cohort study[ 47]? |
| cord-005705-j765ruj1 | Assessing the use of activated protein C in the treatment of severe sepsis Is academic medicine for sale? |
| cord-005705-j765ruj1 | But how generalizable are the data generated by RCTs with excellent internal validity but limited external validity? |
| cord-005705-j765ruj1 | California's new law allowing surrogate consent for clinical research involving subjects with impaired decision- making capacity Suspension of the NIH ARDS Network fluids and catheters treatment trial Control group selection in critical care randomized controlled trials evaluating interventional strategies: an ethical assessment Beyond randomised versus observational studies How best to ventilate? |
| cord-005705-j765ruj1 | Do surrogate decision makers provide accurate consent for intensive care research? |
| cord-005705-j765ruj1 | Does it make ethical sense to distress family members by asking them to consent to yet another study on SDD or on the prevention of gastrointestinal bleeding? |
| cord-005705-j765ruj1 | Finally, will the lack of effect of prone positioning on mortality in RCTs[ 37] discourage clinicians from using this very inexpensive and effective maneuver to improve patient oxygenation, and will these clinicians continue to await an RCT providing"proof"of efficacy[ 30]? |
| cord-005705-j765ruj1 | How many studies will be needed to convince clinicians to use a method they do not want to use? |
| cord-005705-j765ruj1 | How useful are RCTs in critically ill patients? |
| cord-005705-j765ruj1 | Intermittent positive- pressure hyperventilation with high inflation pressures produces pulmonary microvascular injury in rats Improved prognosis of acute respiratory distress syndrome 15 years on Searching for evidence: do n't forget the foundations Effectiveness of antibiotic prophylaxis in critically ill adult patients: systematic review of randomised controlled trials Selective digestive decontamination: for everyone, everywhere? |
| cord-005705-j765ruj1 | Is informed consent always necessary for randomized, controlled trials? |
| cord-005705-j765ruj1 | Medicine based evidence, a prerequisite for evidence based medicine Truth survival in clinical research: an evidence- based requiem? |
| cord-005705-j765ruj1 | Non- therapeutic research in the EU in adults incapable of giving consent? |
| cord-005705-j765ruj1 | Or shall we wait until the"final"meta- analysis is"negative"and"proves"that clinicians were right when they refused to use SDD despite the accumulation of so- called evidence? |
| cord-005705-j765ruj1 | Safeguarding patients in clinical trials with high mortality rates Is the concept of informed consent applicable to clinical research involving critically ill patients? |
| cord-005705-j765ruj1 | The effect of waiving consent on enrollment in a sepsis trial Is informed consent always necessary for randomized controlled trials? |
| cord-005705-j765ruj1 | The integral role of clinical research in clinical care Is informed consent always necessary for randomized, controlled trials? |
| cord-005705-j765ruj1 | What ethical problems do RCTs raise in critically ill patients? |
| cord-005705-j765ruj1 | What have these multimilliondollar trials contributed? |
| cord-005705-j765ruj1 | What is best for ARDS management? |
| cord-005705-j765ruj1 | What is the socioeconomic role of RCTs? |
| cord-005705-j765ruj1 | Why not evaluate new therapeutic interventions sequentially under conditions of genuine equipoise? |
| cord-005705-j765ruj1 | authors: Dreyfuss, Didier title: Is it better to consent to an RCT or to care?: |
| cord-005814-ak5pq312 | * p<0.05 CAN vs NaCI? |
| cord-005814-ak5pq312 | 2) Are whole body changes in VAPCO2 and AVpH associated with parallel changes in regional circulation? |
| cord-005814-ak5pq312 | : We inquired all the nurses of the Intensive Care Unit of an Regional Hospital by an semiestructurated questionary which included personal data: age, sex, contractual relation, professional experience.., and opinion data: do you think to inform relatives is a nurse task?. |
| cord-005814-ak5pq312 | A HEROE? |
| cord-005814-ak5pq312 | A PROGNOSTIC FACTOR? |
| cord-005814-ak5pq312 | After more than 2 years clinical experience two aspects were investigated: What effort is necessary to install and support a CIS, and what is the benefit for patients and personnel on the ICU? |
| cord-005814-ak5pq312 | Are circular circuits safe? |
| cord-005814-ak5pq312 | CO, MAP, CVP, PCWP, PaO?, and Pv~ remained unchan NO administration. |
| cord-005814-ak5pq312 | Case report: A 41 year old man developed typical skin manifestations of HSP following an episode of severe( biliary?) |
| cord-005814-ak5pq312 | GS score difference seems suggestive and can be that an abnormal cerebral activity( hipofisary hormones?) may play a crucial role on onset of ARF in these patients. |
| cord-005814-ak5pq312 | In 35 patients with cardiogenic shock due to ischemic heart disease( N=26), heart failure( N=7) and valvulopathy( N=2), hemod31aamic data including measures of intravascular pressures, cardiac output and mixed venous gases were collected at regular times intervals, at least 3 times a da?. |
| cord-005814-ak5pq312 | In all 13 patients with positive blood cultures the clinical course of S, infection was complicated:? |
| cord-005814-ak5pq312 | In case ot GER persistence at the pH- metry on? |
| cord-005814-ak5pq312 | In this stud?', wc recorded the gastrointestinal motility of critically ill patients with abundant(> 250 mL/24 hours) fasting gastric aspirates. |
| cord-005814-ak5pq312 | Is there any way to individualise the triple H therapy when it is necessary? |
| cord-005814-ak5pq312 | TA Buckle? |
| cord-005814-ak5pq312 | The absence of this mechanism( right heart impairement?) |
| cord-005814-ak5pq312 | Therefore, extreme attention should be paid to the maintenance of an adequate mean arterial blood pressure( above 90 mmHg?) |
| cord-005814-ak5pq312 | We were considered that a patient had Ventilator associated pneumonia( VAP) when the specimens of Bronchoalveolar Lavage( BAL) or Protected Specimen Brush( PSI?,), ebb'ned through the bronchoscope, had one or more microorganisms in concentrations greater than 105 and 103 cfu/ ml respectively. |
| cord-005814-ak5pq312 | Where are we?. |
| cord-005814-ak5pq312 | Which of the next informafions do you think is more important? |
| cord-005814-ak5pq312 | and AVpH also reflect the onset of tissue hypoxia during endotoxemia? |
| cord-005814-ak5pq312 | thrombolytic therapy or pulmonary embolectomy? |
| cord-015021-pol2qm74 | ( 3) Should future clinical trials be based on new classifications of illness such as MODS, SIRS, APACHE III, SAP II, MRM, etc., or should trials be dedicated to specific diseases-urinary tract infections, pneumonia, trauma patients, cardiac surgery and other specific problems, rather than generalized problems of sepsis, the sepsis syndrome and other classifications? |
| cord-015021-pol2qm74 | 3-Is the ACCP classification of sepsis useful at the bedside to select oatients? |
| cord-015021-pol2qm74 | Abnormally high skeletal muscle pO 2 in septic patients and its normalization during recovery: Evidence against tissue hypoxia but for impaired oxygen metabolism of skeletal muscle? |
| cord-015021-pol2qm74 | Administration of exogenous IFN? |
| cord-015021-pol2qm74 | And, finally, how can the participants be sure that the trial will be stopped at the right time, to ensure that no treatment is given to any patient that might be harmful? |
| cord-015021-pol2qm74 | Are all eligible patients being studied, and their results reported? |
| cord-015021-pol2qm74 | Are all the participants truly unbiased about the relative merits of the regimens being studied? |
| cord-015021-pol2qm74 | Before using the model for risk of death in septic patients, is it mandatory to validate it( by calibration, i.e. goodness of fit, and discrin'dnation, i.e., ROC curves) first on a data base using the same definition for sepsis as in the trial and secondly on the placebo group of the trial? |
| cord-015021-pol2qm74 | Can it achives a significant improvement in the septic course, organ dysfunction, and final outcome? |
| cord-015021-pol2qm74 | Conversely, administration of anti- IFN? |
| cord-015021-pol2qm74 | Correlatively the RNI inhibitor MMLA induces in vitro a decrease in the rate of bacterial killing, fxom 78% to 57%, in macrophages triggered with IFN-?+ LPS. |
| cord-015021-pol2qm74 | How can organ dysfunction and/or failure be defined? |
| cord-015021-pol2qm74 | How should we decide which of them should be brought to clinical trial? |
| cord-015021-pol2qm74 | If there is agreement that thin is an appropriate antibiotic protocol, should it not be used in all seriously ill septic patients in the hospital? |
| cord-015021-pol2qm74 | In contrast, GF109203X significantly reduced ICAM-1 expression induced by Interferon- y( IFN-?) |
| cord-015021-pol2qm74 | In fact, the IFN-? and IL-1 induced adhesion of PBMC to cytokine treated HUVEC could be downregulated by the PKC- inhibitor, whereas TNFc~-and LPS- mediated adhesion was not influenced. |
| cord-015021-pol2qm74 | In other words, should we now begin to have clinical trials on specific diseases with causes that are known and can be attacked? |
| cord-015021-pol2qm74 | Interferon-? |
| cord-015021-pol2qm74 | Is like being compared with like-are all the end points and the standards for measuring them clearly defined so that they can not be misunderstood? |
| cord-015021-pol2qm74 | Is there any role for antioxidative therapy in sepsis? |
| cord-015021-pol2qm74 | Is truly informed consent being sought that will satisfy not only the patient's right to choose what happens to him, but also the law of the land? |
| cord-015021-pol2qm74 | MIF secretion also was induced by TNFoc( 1 ng/ ml) and IFN? |
| cord-015021-pol2qm74 | MIF secretion is induced by LPS, TNFc~ and IFN?. |
| cord-015021-pol2qm74 | Macrophages of C57BL/10ScCr mice are incapable of producing interferon-~( IFN~) which we could show to be obligatory for the production of IFN? |
| cord-015021-pol2qm74 | On closer investigation the impaired IFN? |
| cord-015021-pol2qm74 | The IFN? |
| cord-015021-pol2qm74 | The absence of sensitization to LPS in Lps d C57BL/10ScCr mice was identified as being due to their inability to produce interferon-7( IFN?). |
| cord-015021-pol2qm74 | The clinical"take"rate o? cultured epithelial autografts( CEA) has been observed to Increase with transplantation to allodermls, but the reasons for the improved clinical performance have not yet been defined. |
| cord-015021-pol2qm74 | The inability to produce adequate amounts of IL-2, most likely attributable to alterations in the transmission of signals from the cell membrane to the nucleus, results in incomplete proliferative T- cell responses to antigenic stimuli, while a lack of? |
| cord-015021-pol2qm74 | There are reports of nentrophil dysfunction in inflammatory disorders of the skin( 2), Are there dysfunctions concerning the unspecific host defense in SIRS, as well? |
| cord-015021-pol2qm74 | This has not happened, however, and the question is"Why not"? |
| cord-015021-pol2qm74 | This might be due to a preexisting( genetic?) or more likely to an epiphenomenal receptor defect. |
| cord-015021-pol2qm74 | We have investigated the proinflaznmatory oytokine secretion patter~ by PMN in patients following major~hermal or tra~ matic injury and in volunteers fellowinq endotoxemia.? |
| cord-015021-pol2qm74 | What are the definitions? |
| cord-015021-pol2qm74 | What are the issues, then, in 1994, to be dealt with at this symposium and congress? |
| cord-015021-pol2qm74 | What are the mechanisms? |
| cord-015021-pol2qm74 | What is the aplpiieability of study results in typical clinical situations? |
| cord-015021-pol2qm74 | What is the availability of speciftc antibiotics at a participating hospital? |
| cord-015021-pol2qm74 | Will the patient's physicians agree to the protocol choice? |
| cord-015021-pol2qm74 | Will they be helpful in the study and esro of patients? |
| cord-015021-pol2qm74 | Will this contribute to better clinical trials, information basis and better research? |
| cord-015021-pol2qm74 | Will we benefit Oleo from a more precise classification and definition of a non- outjty, a hodgu- podge of human disorders which have charsmeristic.s and manifestations of tissue injury, inflammation and infactian? |
| cord-015021-pol2qm74 | and?-IFN and T- helper-2( Th2) acting principally in inducing antibody formation with a secretion of IL-4, IL-5, IL-10 and TNF-[3 has still to be established within the context of major trauma. |
| cord-015021-pol2qm74 | anti- IFN-?( p<0.05). |
| cord-015021-pol2qm74 | or is it better to use a specific model for each trial? |
| cord-015021-pol2qm74 | ~is s?. |