bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
monoclonal antibodies	917
monoclonal antibody	636
blood donors	631
blood transfusion	543
phage display	489
immune response	418
neutralizing antibodies	405
blood components	378
blood donation	364
immune system	360
whole blood	344
antibody responses	323
immune responses	311
human monoclonal	310
blood products	291
respiratory syndrome	282
red blood	274
antibody response	273
red cell	271
specific antibodies	260
infectious diseases	259
neutralizing antibody	251
clinical trials	243
acute respiratory	236
antibody titers	232
transfusion medicine	223
infected cells	219
severe acute	212
virus infection	211
blood group	209
intravenous immunoglobulin	205
immunodeficiency virus	204
red cells	201
antibody fragments	199
blood cells	197
influenza virus	190
human immunodeficiency	188
specific antibody	180
immune complexes	175
neutralizing activity	173
amino acid	172
broadly neutralizing	168
bone marrow	164
platelet concentrates	163
igg antibodies	159
human igg	156
convalescent plasma	156
blood donor	156
virus type	151
escherichia coli	147
blood units	145
nucleic acid	141
blood collection	141
cell surface	141
cord uid	140
doc id	140
blood banks	139
blood samples	138
binding site	138
bispecific antibodies	137
may also	135
human antibody	135
blood cell	130
heavy chain	129
egg yolk	128
blood bank	128
light chain	127
side effects	124
ng ml	122
passive immunization	121
effector functions	120
viral infections	120
gene therapy	119
lupus erythematosus	117
adverse events	117
cell lines	117
mg ml	116
filamentous phage	116
rheumatoid arthritis	115
high affinity	115
infectious disease	113
igg antibody	113
peripheral blood	112
transfusion service	111
antibody production	111
animal models	111
pregnant women	111
western blot	110
transfusion reactions	110
passive immunity	109
systemic lupus	109
therapeutic antibodies	108
serum samples	106
platelet count	106
human antibodies	105
flow cytometry	104
respiratory syncytial	103
significantly higher	103
sars coronavirus	103
viral infection	102
antibody binding	102
bacterial contamination	102
chain variable	102
united states	102
positive results	101
bispecific antibody	99
mg kg	99
complement activation	98
room temperature	98
syncytial virus	98
light chains	97
antibody titer	97
significant difference	96
control group	96
measles virus	95
recent years	95
plasmodium falciparum	95
protein microarrays	95
virus neutralization	95
syndrome coronavirus	94
blood supply	93
fc receptor	93
amino acids	93
dendritic cells	93
autoimmune diseases	92
dengue virus	92
blood donations	91
iu ml	90
autologous blood	88
cell line	87
cell responses	87
quality control	86
immune globulin	86
blood safety	85
display technology	85
recombinant antibodies	84
growth factor	84
herpes simplex	84
antibody therapy	83
hbv dna	83
class i	82
transfusion services	81
polyclonal antibodies	80
serum antibody	79
antibody screening	79
antibody levels	79
antibody libraries	79
goat anti	79
target cells	79
fully human	79
domain antibodies	79
viral antigens	78
vaccine development	78
iga antibodies	78
single chain	77
cell culture	77
tumor cells	76
ebola virus	76
spike protein	76
cancer cells	76
performed using	76
maternal antibodies	76
antiglobulin test	75
neutralizing human	75
hybridoma technology	75
adaptive immune	74
first time	74
factor viii	74
innate immune	73
antibody tests	73
two different	73
var csa	72
blood component	72
simplex virus	71
public health	71
hcv rna	71
clinical trial	71
critically ill	71
viral load	71
type i	71
stem cell	71
gamma globulin	71
pg ml	70
cell activation	70
display library	70
immunosorbent assay	70
transmissible gastroenteritis	70
platelet transfusion	70
respiratory tract	70
phase i	69
two groups	68
fusion protein	68
cell receptor	68
blood groups	68
plasmon resonance	68
scfv antibodies	67
lateral flow	67
commercially available	67
cardiac surgery	67
antibodies may	67
binding affinity	67
donor selection	67
high levels	67
surface plasmon	67
antibody complexes	66
human serum	66
fc receptors	66
cfu ml	66
west nile	66
mouse model	66
recombinant antibody	66
breast cancer	66
frozen plasma	66
linked immunosorbent	66
alternative pathway	65
national blood	65
viral replication	65
fusion proteins	64
neutralizing monoclonal	64
previously described	64
immune cells	64
infected individuals	64
antibody library	63
binding domain	63
receptor binding	63
infected patients	63
affinity maturation	63
igm antibodies	63
serum igg	62
stem cells	62
immunoglobulin therapy	62
clinical use	62
blood service	62
fresh frozen	61
single domain	61
blood services	61
igy antibodies	60
statistically significant	60
rabies virus	60
negative control	60
protective immunity	60
antibodies directed	60
necrosis factor	60
surface antigen	60
serum therapy	59
antibody testing	59
immune complex	59
antibody fragment	59
large number	59
mumps virus	58
passive transfer	58
monoclonal anti	58
epitope mapping	58
nk cells	58
passive immunotherapy	58
display libraries	58
electron microscopy	58
cancer therapy	58
viral proteins	58
patients undergoing	57
infectious agents	57
novel coronavirus	57
transfusion therapy	57
plasma samples	57
nile virus	57
blood banking	56
widely used	56
blood loss	56
envelope glycoprotein	56
ill patients	56
human immunoglobulin	55
viral antigen	55
test results	55
vaccinia virus	55
bacterial infections	55
reactive antibodies	55
specific igg	55
important role	54
case report	54
scansystem tm	54
three times	54
based therapies	54
hbv infection	54
humoral immune	54
high throughput	53
highly conserved	53
positive samples	53
false positive	53
chain reaction	53
see table	53
staphylococcus aureus	53
pm dm	53
clinical signs	53
polyclonal antibody	53
antigen binding	52
polymerase chain	52
specific monoclonal	52
health care	52
barr virus	52
cord blood	52
human mabs	52
recombinant proteins	52
patients receiving	52
chain antibodies	52
protein expression	51
human anti	51
transfusion practice	51
plasma cells	51
adverse reactions	51
antigen receptor	51
molecular weight	51
transgenic mice	51
last years	51
platelets stored	51
antibodies specific	51
guinea pig	50
donate blood	50
host cell	50
antibodies targeting	50
host immune	50
systematic review	50
results show	50
statistical analysis	50
fab fragments	50
present study	50
therapeutic efficacy	49
virus vaccine	49
domain antibody	49
mhc class	49
buffy coat	49
variable domain	49
risk factors	49
red cross	49
natural killer	49
dependent enhancement	49
antibody test	49
coronavirus disease	49
clinical practice	49
binding sites	48
clinically significant	48
porcine reproductive	48
variable regions	48
healthy donors	48
heavy chains	48
human immune	48
coronavirus antibody	48
even though	48
secondary antibody	48
birth weight	47
positive control	47
safe blood	47
positive result	47
host cells	47
high risk	47
cd cells	47
recombinant human	47
antibody repertoire	47
days post	47
direct antiglobulin	47
potent neutralizing	47
viral diseases	47
single cell	46
antigen detection	46
variable fragment	46
may occur	46
chain antibody	46
high sensitivity	46
class ii	46
igg fc	46
tumor necrosis	46
chicken egg	46
blood centre	46
university hospital	46
connective tissue	46
blood centers	46
therapeutic antibody	46
wide range	45
blood pressure	45
intensive care	45
adverse effects	45
immune serum	45
mononuclear cells	45
pathogen inactivation	45
cell cultures	45
chimeric antigen	45
cd cd	45
respiratory distress	45
hiv infection	45
fetal dna	45
animal model	45
binding activity	45
passive protection	45
positive antibody	44
therapeutic mabs	44
virus infections	44
total number	44
years old	44
fc region	44
yolk antibodies	44
naturally occurring	44
effector cells	44
high frequency	44
variable region	44
pcr assay	44
influenza vaccine	44
high level	44
blood product	44
antibody phage	44
informed consent	44
previous studies	44
antibody gene	44
antibody titres	44
significant differences	44
recent studies	44
target cell	43
protein microarray	43
plasma therapy	43
potent neutralization	43
botulinum neurotoxin	43
results suggest	43
using phage	43
antibody generation	43
clostridium difficile	43
least one	43
ex vivo	43
syndrome virus	42
animal species	42
protective efficacy	42
blood center	42
general hospital	42
sars patients	42
viral vectors	42
mumps vaccine	42
commonly used	42
nucleic acids	42
virus isolation	42
existing antibodies	42
associated coronavirus	42
affi nity	42
gel test	42
rbc transfusion	42
lung injury	42
cov infection	42
serum antibodies	42
antibodies produced	42
surface antigens	42
bfe changes	41
recent study	41
clinical studies	41
time pcr	41
sle patients	41
voluntary blood	41
results obtained	41
antibody detection	41
antibody identification	41
storage time	40
complement system	40
cell response	40
replacement therapy	40
gene transfer	40
specific igy	40
enveloped viruses	40
dependent cellular	40
feline infectious	40
therapeutic potential	40
years ago	40
buffy coats	40
nervous system	40
body weight	40
infectious peritonitis	40
live attenuated	40
structural proteins	40
blood volume	40
several studies	39
virus vaccines	39
epithelial cells	39
type ii	39
viral entry	39
hla antibodies	39
increased risk	39
platelet pools	39
new york	39
cell membrane	39
cd binding	39
anti hpa	39
enzyme immunoassay	39
virus particles	39
chain fv	38
mouth disease	38
infectious virus	38
negative results	38
hcv infection	38
results indicate	38
per year	38
drug administration	38
per unit	38
rare blood	38
determine whether	38
year old	38
humoral immunity	38
mer rpl	38
factor receptor	38
quality system	38
world health	38
quality assurance	38
dose intravenous	38
septic shock	37
live virus	37
high specificity	37
synovial fluid	37
natural infection	37
encephalitis virus	37
expression levels	37
hb level	37
phage library	37
blot analysis	37
rabbit igg	37
clinical development	37
donor screening	37
low levels	37
age group	36
animal viruses	36
controlled trial	36
information security	36
therapeutic agents	36
mediated cytotoxicity	36
tm platelet	36
plt count	36
quality management	36
bacterial detection	36
significantly lower	36
positive dat	36
hbc positive	36
membrane protein	36
hla class	36
infectious agent	36
surface proteins	36
placental infection	36
different types	36
healthy individuals	36
antibodies using	36
platelet kit	36
three different	36
iga antibody	36
mass spectrometry	36
blood establishments	36
may lead	36
polyclonal anti	36
large numbers	36
crystal structure	36
mucosal immunity	36
antibodies isolated	35
detection limit	35
bovine serum	35
cytokine storm	35
allogeneic blood	35
donated blood	35
immunized animals	35
solid phase	35
general population	35
spleen cells	35
cancer immunotherapy	35
cell therapy	35
igm antibody	35
cell count	35
plasma fractionation	35
patients treated	35
viral rna	35
i ii	35
first step	35
coagulation factors	35
coronavirus infection	35
viral particles	35
data suggest	35
mediated immunity	35
antigen presentation	35
vaccine candidates	35
middle east	35
therapeutic applications	35
membrane proteins	35
mortality rate	35
mouse igg	35
rheumatoid factor	35
cell separator	35
antibody titre	35
high dose	35
units per	35
antibody molecules	34
envelope protein	34
mouse monoclonal	34
fc fragment	34
cells expressing	34
cells infected	34
coat protein	34
primary immunodeficiency	34
long term	34
vero cells	34
cancer patients	34
salmonella typhimurium	34
described previously	34
sickle cell	34
hong kong	34
endothelial cells	34
highly specific	34
innate immunity	34
solid tumors	34
tumor cell	34
intravenous immune	34
molecular biology	34
cellular cytotoxicity	34
window period	34
female donors	34
rabbit anti	34
scfv antibody	34
indirect antiglobulin	34
neutralizing mabs	34
human il	34
alloimmune thrombocytopenia	34
small number	34
circulating antibodies	33
enzyme treated	33
antibody expression	33
neutralizing epitopes	33
severe thrombocytopenia	33
blood transfusions	33
antibody concentration	33
vaccine design	33
transfusion safety	33
post transfusion	33
clinical symptoms	33
fully automated	33
reverse transcriptase	33
igg molecules	33
constant regions	33
significantly reduced	33
hemolytic anemia	33
nasal secretions	33
antibody therapeutics	33
cell epitopes	33
bacterial screening	33
plasmid dna	33
closely related	33
donor blood	32
binding protein	32
clinical samples	32
transfused patients	32
equine influenza	32
secretory iga	32
specific igm	32
control groups	32
cd antibody	32
conjugated goat	32
mammalian cells	32
mucosal immune	32
mmr vaccine	32
platelet storage	32
guinea pigs	32
taken together	32
variable domains	32
gene expression	32
cryptococcus neoformans	32
mean age	32
health organization	32
infected cell	32
chikungunya virus	32
pseudomonas aeruginosa	32
disease virus	32
time donors	32
protect mice	32
inflammatory diseases	32
antibody therapies	32
specific anti	31
serum iga	31
single donor	31
abo blood	31
therapeutic use	31
different species	31
myeloma cells	31
target antigen	31
antibody complex	31
specific antigens	31
lymphoid cells	31
antibody discovery	31
platelet quality	31
column agglutination	31
bacterial growth	31
group system	31
multiple sclerosis	31
recombinant protein	31
candida albicans	31
streptococcus mutans	31
complement fixation	31
care unit	31
structural basis	31
cell fusion	31
immune sera	31
cell concentrates	31
cell sorting	31
also used	31
antiviral drugs	31
antibody sequences	31
human sera	31
filamentous bacteriophage	31
biotinylated antibodies	31
well tolerated	31
results showed	31
serological assays	31
times higher	31
vaccination strategies	31
phage displaying	31
pathogen detection	31
affinity antibodies	31
platelet antigens	30
haemolytic disease	30
gastroenteritis virus	30
plasma products	30
transfusion transmitted	30
distress syndrome	30
trauma patients	30
somatic mutations	30
negative controls	30
time blood	30
reagent lots	30
platelet products	30
antibody engineering	30
least two	30
phase iii	30
vaccine efficacy	30
host disease	30
protein array	30
one case	30
acid residues	30
yellow fever	30
igg subclasses	30
cell wall	30
another study	30
dental caries	30
see chapter	30
serious adverse	30
additive solution	30
th cells	30
cell types	30
disease control	30
study showed	30
within hours	30
cov spike	30
surface protein	30
per patient	30
transfusion reaction	30
binding antibodies	30
horseradish peroxidase	30
may cause	30
blood sample	29
significantly increased	29
hospital transfusion	29
maternal antibody	29
gold nanoparticles	29
protein interactions	29
neonatal alloimmune	29
will allow	29
fc fusion	29
lactogenic immunity	29
antibodies generated	29
extremely rare	29
antibiotic therapy	29
also known	29
antibody activity	29
protective effect	29
influenza viruses	29
outer membrane	29
central nervous	29
cancer cell	29
corrective actions	29
viral inactivation	29
also observed	29
plasma transfusion	29
treated rbcs	29
mycobacterium tuberculosis	29
acid sequence	29
wild type	29
canine parvovirus	29
antibody specificity	29
therapeutic monoclonal	29
phase ii	29
lung cancer	29
like particles	29
negative blood	29
allergic reactions	29
mean value	29
presenting cells	29
neonatal fc	29
clinical applications	28
nucleocapsid protein	28
virus entry	28
recent advances	28
significant antibodies	28
relatively high	28
cell receptors	28
high quality	28
young people	28
mediated immune	28
rbc units	28
target antigens	28
genetically engineered	28
positive donors	28
effector function	28
conventional antibodies	28
premature infants	28
molecules per	28
ml kg	28
donor base	28
humoral response	28
platelet transfusions	28
cell lymphoma	28
previously reported	28
neutralising antibody	28
effector cell	28
adaptive immunity	28
significant reduction	28
marrow transplantation	28
whole virus	28
three patients	28
lymph nodes	28
specific cd	28
innate lymphoid	28
based vaccines	28
cd bs	28
specific human	28
also shown	28
drug delivery	28
cells ml	28
mouse models	28
hemorrhagic fever	28
escape mutants	27
linear epitope	27
related complications	27
cross reactivity	27
biotinylated antibody	27
conformational changes	27
expressing cells	27
highly sensitive	27
significant increase	27
reported cases	27
last two	27
plasma derivates	27
placental malaria	27
hospitalized patients	27
antibody specific	27
cd monoclonal	27
tissue culture	27
disease activity	27
relatively low	27
drug conjugates	27
serum albumin	27
envelope glycoproteins	27
cd cell	27
post irradiation	27
east respiratory	27
veterinary medicine	27
dextransucrase antibody	27
chemokine receptor	27
positive cells	27
one patient	27
effective treatment	27
viral pathogens	27
within days	27
clinical efficacy	27
bacillus anthracis	27
well plates	27
neutralization test	27
cell transplantation	27
randomized controlled	27
serological testing	27
human igm	27
plasma membrane	27
may provide	27
human rotavirus	27
currently available	27
molecular methods	27
protective antibodies	27
human origin	26
autoimmune disease	26
gel electrophoresis	26
bovine coronavirus	26
immune libraries	26
hpa antibodies	26
routine use	26
short period	26
regression analysis	26
rights reserved	26
inactivated vaccine	26
therapeutic effect	26
vaccine failure	26
generation sequencing	26
oral administration	26
passive antibody	26
inflammatory cytokines	26
classical pathway	26
transplant recipients	26
antiphospholipid syndrome	26
small amounts	26
alkaline phosphatase	26
rhesus macaques	26
disease severity	26
sequence analysis	26
expression system	26
summary conclusions	26
brain barrier	26
assay format	26
magnetic nanoparticles	26
fever virus	26
growth factors	26
many countries	26
highly potent	26
nonneutralized fraction	26
low level	26
epidermal growth	26
regional blood	26
antibody directed	26
shiga toxin	26
will help	25
gastrointestinal tract	25
influenza vaccines	25
may result	25
transmitted infections	25
phage libraries	25
bovine colostrum	25
two years	25
study group	25
endemic areas	25
somatic hypermutation	25
virus load	25
czech republic	25
fc gamma	25
fab fragment	25
zika virus	25
acute lung	25
past years	25
neutralizing anti	25
biofilm formation	25
laboratory diagnosis	25
western blotting	25
staphylococcal enterotoxin	25
using antibody	25
mean platelet	25
display system	25
dna vaccine	25
based therapeutics	25
using different	25
high titers	25
two patients	25
detection methods	25
listeria monocytogenes	25
specific binding	25
cell free	25
th day	25
general practitioners	25
nipah virus	25
specific immune	25
histocompatibility complex	25
also found	25
combinatorial antibody	25
data indicate	25
single dose	25
severe covid	25
immune library	25
pancreatic cancer	25
fibrin glue	25
normal human	24
different methods	24
cytopathic effect	24
limited number	24
pall ebds	24
new technology	24
cellular immunity	24
per rbc	24
viral shedding	24
mg dl	24
year period	24
five years	24
serologic tests	24
malaria vaccine	24
medical center	24
causative agent	24
virus replication	24
ultrio assay	24
negative result	24
surgery patients	24
will also	24
bound antibody	24
active immunization	24
ana lysis	24
capsid protein	24
antibody interactions	24
cells secreting	24
control samples	24
many different	24
authors declare	24
national institute	24
hiv antibodies	24
ii clinical	24
antibodies binding	24
gene delivery	24
large amounts	24
dependent cell	24
myasthenia gravis	24
murine monoclonal	24
protein arrays	24
clinical outcome	24
thalassemic patients	24
antiphospholipid antibodies	24
analysis showed	24
mucosal surfaces	24
years later	24
cancer treatment	24
high titer	24
clinical settings	24
rich plasma	24
next generation	24
based assays	24
platelet concentration	24
high concentrations	24
group antigens	24
major histocompatibility	24
antibody may	24
pcr amplification	24
infected pigs	24
plaque reduction	24
viral vector	24
serological tests	24
adverse reaction	24
van der	24
mumps infection	23
haemolytic anaemia	23
biological activity	23
immunoglobulin preparations	23
transgenic plants	23
human recombinant	23
many cases	23
human platelet	23
primary antibody	23
vaccine strain	23
fab i	23
neutralization assay	23
hela cells	23
antigenic determinants	23
clinical course	23
rapid detection	23
time points	23
serum half	23
mabs may	23
emerging infectious	23
antibody targeting	23
four different	23
immunoglobulin replacement	23
data set	23
ml per	23
two decades	23
infected mice	23
binding proteins	23
viral antibody	23
anticardiolipin antibodies	23
coiled coil	23
may require	23
cell antigens	23
inflammatory responses	23
white cell	23
expression vector	23
positive sera	23
uric acid	23
prostate cancer	23
surface display	23
white blood	23
mediated neutralization	23
cells via	23
take place	23
may reduce	23
helicobacter pylori	23
virus envelope	23
hematopoietic cells	23
one single	23
ml min	23
determining regions	23
following vaccination	23
nonhuman primates	23
detected using	23
naturally infected	23
fused cells	23
vitro studies	23
per well	23
fmd virus	23
low cost	23
antibody screen	22
blood system	22
donor cells	22
ethnic groups	22
mumps outbreaks	22
fab library	22
mammalian cell	22
medical staff	22
borrelia burgdorferi	22
avian influenza	22
specific antigen	22
may play	22
sandwich elisa	22
renal disease	22
virus neutralizing	22
hemolytic transfusion	22
diagnostic tests	22
culture supernatant	22
retrospective analysis	22
vivo expression	22
unpublished data	22
compatible platelets	22
platelet concentrate	22
neutralizing potency	22
among patients	22
oral immunization	22
allogenic blood	22
myocardial infarction	22
neutralization assays	22
like receptors	22
combination therapy	22
rabbit serum	22
circumsporozoite protein	22
two doses	22
natural antibodies	22
cell function	22
final concentration	22
virus shedding	22
clinical disease	22
definitive diagnosis	22
cell lung	22
transfusion chain	22
cytokine release	22
using monoclonal	22
subunit vaccine	22
igg concentrates	22
conformational epitopes	22
european countries	22
convalescent serum	22
transfusion center	22
bacterial pathogens	22
human mab	22
constant region	22
blood flow	22
protective immune	22
sorted cells	22
will provide	22
rotavirus infection	22
plasma donors	22
serum sample	22
cellular immune	22
virus challenge	22
group i	22
protective antigen	22
well known	22
bacterial infection	22
low risk	22
two major	22
associated virus	22
successfully used	22
humanized mice	22
effective vaccines	22
specific mabs	22
patients suffering	22
cell death	22
one day	22
last decade	22
vascular endothelial	22
humanized antibody	22
immunoglobulin genes	22
clinical stage	22
also tested	22
one study	22
seroconversion panels	22
corticosteroid treatment	22
blood lymphocytes	21
gene products	21
deferred donors	21
blood plasma	21
antiviral immune	21
agglutination technology	21
many years	21
blood collected	21
excessive bleeding	21
data analysis	21
probably due	21
bact alert	21
high antibody	21
low birthweight	21
two methods	21
protective antibody	21
rhesus monkeys	21
toxoplasma gondii	21
large scale	21
predonation hb	21
rhd gamma	21
lymphoid tissues	21
old individuals	21
laboratory testing	21
immune effector	21
transfusion related	21
pandemic influenza	21
severe cases	21
donor population	21
humanized monoclonal	21
convalescent patients	21
one year	21
magnetic cards	21
simultaneous detection	21
patients received	21
cell proliferation	21
real time	21
cde cde	21
synergistic neutralization	21
toxic shock	21
vista tm	21
antigenic modulation	21
measured using	21
open reading	21
coronavirus spike	21
mean hb	21
mediated effector	21
effective use	21
samples collected	21
reverse transcription	21
mg day	21
different animal	21
hcv antibodies	21
bacterial strains	21
primary immunodeficiencies	21
active immunity	21
inhibitory activity	21
humanized antibodies	21
affinity chromatography	21
killer cells	21
subunit vaccines	21
yeast surface	21
transfusion policy	21
time consuming	21
patient received	21
polyethylene glycol	21
sequence identity	21
antiviral antibody	21
blood mononuclear	21
tyrosine kinase	21
cell transfusion	21
human plasma	21
surface expression	21
severe disease	21
primed donor	21
protects mice	21
gold standard	21
platelet refractoriness	21
specifi city	21
igg mab	21
repertoire mining	21
murine model	21
liver disease	21
early detection	21
clinical setting	21
domain iii	21
organ transplantation	20
gnotobiotic pigs	20
therapeutic mab	20
antibody protects	20
blood grouping	20
also demonstrated	20
antigenic specificity	20
reduced mortality	20
less frequent	20
tetanus toxin	20
helical coiled	20
using two	20
false negative	20
specific ige	20
tissue damage	20
marrow transplant	20
clinically relevant	20
von behring	20
national health	20
bacterial cells	20
spytag spycatcher	20
mumps outbreak	20
clinical benefit	20
two weeks	20
nodavirus antibody	20
anthrax toxin	20
shock syndrome	20
may contribute	20
controlled clinical	20
fda approved	20
thromboembolic events	20
experimentally infected	20
bovine rotavirus	20
donor recruitment	20
national haemovigilance	20
amperometric immunosensor	20
blood screening	20
reference laboratory	20
expression vectors	20
inflammatory response	20
predictive value	20
immunosensor based	20
peptide libraries	20
preliminary results	20
different antibody	20
neutralizing hiv	20
sensitive detection	20
three weeks	20
broad spectrum	20
cells using	20
ge healthcare	20
weeks gestation	20
analysis using	20
inactivated virus	20
human coronaviruses	20
safety profile	20
emerging viruses	20
retrospective study	20
buffered saline	20
well established	20
plasma units	20
using human	20
dependent manner	20
adult patients	20
myeloma cell	20
risk factor	20
three years	20
positive blood	20
hepatitis virus	20
leukocyte antibodies	20
hiv positive	20
washed three	20
iron stores	20
disease progression	20
virus strains	20
chicken igy	20
control study	20
working group	20
low frequency	20
tge virus	20
delivery systems	20
potential therapeutic	20
tumor antigens	20
antibody administration	20
mice infected	20
genital secretions	20
based therapy	20
also reported	19
may help	19
camelid single	19
cells may	19
well documented	19
linear epitopes	19
among different	19
sample volume	19
critical role	19
thrombocytopenic purpura	19
library construction	19
throughput screening	19
ten years	19
positive reactions	19
new zealand	19
severe sepsis	19
human neutralizing	19
antibody formats	19
receptor expression	19
may explain	19
repeat blood	19
cd expression	19
immunological memory	19
highly efficient	19
antibody repertoires	19
decoy epitope	19
single nucleotide	19
human fc	19
phage antibody	19
hna antibodies	19
first week	19
vaccine immunogens	19
thrombocytopenic patients	19
bispecific single	19
type virus	19
risk reduction	19
patients without	19
coli cells	19
randomly selected	19
virus antibody	19
six months	19
clinical specimens	19
acid testing	19
different epitopes	19
igg levels	19
young adults	19
porcine circovirus	19
toxin neutralization	19
mouse antibodies	19
transfusion purpura	19
intravenous immunoglobulins	19
will likely	19
hiv envelope	19
cell lysates	19
antibody preparations	19
high avidity	19
rbc transfusions	19
high resolution	19
life cycle	19
hospital blood	19
antibody fab	19
volunteer donors	19
preoperative autologous	19
acute infection	19
sg hev	19
antiviral mabs	19
multiplex pcr	19
host response	19
diabetes mellitus	19
current status	19
human disease	19
immune repertoire	19
apheresis platelet	19
cell units	19
studies using	19
pig serum	19
serological methods	19
acid sequences	19
gamma irradiation	19
component therapy	19
antibody genes	19
animal studies	19
direct detection	19
active disease	19
early stages	19
surgical procedures	19
three days	19
treatment options	19
antibodies induced	19
major challenge	19
low affinity	18
fc fragments	18
neutralising antibodies	18
caucasian population	18
blood establishment	18
higher antibody	18
bacterial viruses	18
iron depletion	18
antibodies anti	18
united kingdom	18
packed red	18
inflammatory bowel	18
clinical relevance	18
positive controls	18
first generation	18
platelet counts	18
massive transfusion	18
dna binding	18
patient serum	18
high prevalence	18
continuous cultures	18
transmissible infections	18
ns ns	18
selectin expression	18
neutralizing epitope	18
inhibitory effect	18
clinical situations	18
rna viruses	18
plaque assay	18
transfusion trigger	18
lst system	18
magnetic beads	18
equal volume	18
standard methods	18
low birth	18
specific iga	18
split inteins	18
apheresis procedures	18
transfusion hepatitis	18
hybrid rhesus	18
table shows	18
better understanding	18
promising results	18
host defense	18
cdr regions	18
automated system	18
cell panel	18
two mabs	18
homologous blood	18
monolisa hcv	18
human fab	18
antibodies showed	18
sle sera	18
th centile	18
envelope proteins	18
donating blood	18
procleix ultrio	18
japanese encephalitis	18
standard operating	18
shear stress	18
efficient method	18
virus strain	18
rbc collection	18
newborn calves	18
donor platelets	18
potassium level	18
cmv infection	18
true positive	18
partial ds	18
gambro bct	18
russian federation	18
like receptor	18
nitrocellulose membrane	18
variable fragments	18
yersinia pestis	18
per day	18
process time	18
nk cell	18
deficient mice	18
end point	18
inh titre	18
optimised scansystem	18
may reflect	18
clinical status	18
chondroitin sulfate	18
low hb	18
viral genome	18
operating procedures	18
converting enzyme	18
vaccinated animals	18
fc domain	18
operative infections	18
serum dilution	18
iga response	18
animals treated	18
modified live	18
synthetic human	18
outcome review	18
developed countries	18
ocular secretions	18
analyzed using	18
neutralization potency	18
patients infected	18
piezoelectric immunosensor	18
autovue innova	18
antibody concentrations	18
platelet yield	18
virus glycoprotein	18
viral glycoproteins	18
cell separators	18
endothelial growth	18
influenza pandemic	18
high incidence	18
detection assays	18
genomic dna	18
total rna	18
near future	18
neutralizing effect	18
epitope binning	18
clinical diagnosis	18
dependent antibody	18
wt wt	18
normal rhd	18
haemophilus influenzae	18
pulmonary edema	18
human cd	18
erythrocyte antibodies	18
inhalational anthrax	18
yeast display	18
free fetal	18
two types	18
viral envelope	18
transfusion centers	18
derived antibodies	18
study period	18
used successfully	18
control sera	18
clinical manifestations	18
different antibodies	18
storage period	18
coronavirus infections	18
virus transmission	18
influenza infection	18
vox sang	17
medicinal products	17
infected donors	17
vh gene	17
clinical impact	17
volunteer blood	17
primary infection	17
domestic animals	17
broad range	17
signal intensity	17
early diagnosis	17
human single	17
difficile infection	17
activating fcgrs	17
scfv library	17
immunocompromised patients	17
highly effective	17
differ significantly	17
antibodies derived	17
hybridoma cells	17
information system	17
tested negative	17
antibody molecule	17
lyme disease	17
developing countries	17
much lower	17
first two	17
transcription factor	17
viral neutralization	17
respiratory disease	17
molecular mechanisms	17
results may	17
clinical evidence	17
genetic material	17
human cells	17
short time	17
molecular mimicry	17
conformational epitope	17
specific primers	17
humanized anti	17
two distinct	17
wnv infection	17
rabbit antibody	17
young children	17
rapid identification	17
replacement donors	17
lacteal secretions	17
specific epitopes	17
cell entry	17
normal mice	17
among others	17
rotavirus antibodies	17
study design	17
elisa assays	17
organ failure	17
zoster virus	17
antiphospholipid antibody	17
controlled trials	17
powerful tool	17
linked immunoassay	17
different anti	17
klebsiella pneumoniae	17
immune memory	17
lower respiratory	17
fi lm	17
studies showed	17
studies suggest	17
potential donors	17
potent hiv	17
normal range	17
affinity human	17
alexa fluor	17
antibody affinity	17
higher prevalence	17
viral disease	17
gene sequences	17
additional file	17
igg monoclonal	17
variable heavy	17
secreting antibody	17
adhesion molecule	17
microtiter plate	17
potential applications	17
idiotypic antibodies	17
ab titers	17
neutralized virus	17
will need	17
chain fragment	17
mediated phagocytosis	17
process control	17
antibody heavy	17
hiv antibody	17
tested positive	17
genetic engineering	17
positive test	17
binding capacity	17
cd i	17
day post	17
subsequent studies	17
single injection	17
humanized mabs	17
ige immune	17
potent cross	17
tissue disease	17
upper respiratory	17
fc portion	17
virus antibodies	17
dependent cytotoxicity	17
affinity binding	17
also positive	17
first transfusion	17
murine mabs	17
optical density	17
random donor	17
early stage	17
viral etiology	17
prp sc	17
small molecule	17
functional antibodies	17
new blood	17
platelet components	17
chronic lymphocytic	17
mammary gland	17
healthy volunteers	17
infected animals	17
attenuated influenza	17
management system	17
antigenic sites	17
prion protein	17
cerebrospinal fluid	17
pathogen reduction	17
chicken antibodies	16
predefined specificity	16
reading frame	16
male donors	16
immune antibodies	16
gel filtration	16
hemolytic disease	16
intravenous use	16
median age	16
european union	16
stranded rna	16
animals receiving	16
inhibitory receptor	16
dendritic cell	16
highly vaccinated	16
leukemia virus	16
igg anti	16
several years	16
autoimmune hemolytic	16
incubation period	16
vn antibody	16
transfusion activities	16
antibody fc	16
human use	16
engineered antibody	16
hbc negative	16
make human	16
antigen specific	16
haemovigilance data	16
high cost	16
sample preparation	16
antitumor activity	16
will require	16
circulatory overload	16
components issued	16
existing immunity	16
per se	16
antibody deficiency	16
cell immunity	16
vaccine candidate	16
viral clearance	16
findings suggest	16
hiv gp	16
per ml	16
will continue	16
also performed	16
significant changes	16
following transfusion	16
spatial neighbors	16
antibody recognition	16
abo group	16
rapid development	16
antibody arrays	16
core antigen	16
challenge model	16
local population	16
viral hepatitis	16
proinflammatory cytokines	16
agglutination test	16
clinical response	16
pregnant woman	16
negative bfe	16
maternally derived	16
working party	16
fl uorescence	16
related acute	16
three blood	16
rna detection	16
immune cell	16
old male	16
antibody microarrays	16
intercept blood	16
kawasaki disease	16
human blood	16
also showed	16
signal transduction	16
antibody syndrome	16
scarlet fever	16
rna testing	16
also included	16
cd positive	16
symptom onset	16
antigen may	16
muscle cells	16
collaborative study	16
genetically modified	16
sample collection	16
internal controls	16
different antigens	16
positive donations	16
gestational age	16
whole cell	16
also present	16
serial dilutions	16
primary isolates	16
well plate	16
increased susceptibility	16
three months	16
inhibition assay	16
viral nucleic	16
samples obtained	16
new technologies	16
medical treatment	16
antibodies raised	16
high doses	16
borne encephalitis	16
killer cell	16
one unit	16
evaluated using	16
adverse event	16
synthetic peptides	16
generate antibodies	16
hendra virus	16
febrile non	16
viral capsid	16
measurement system	16
many patients	16
quality assessment	16
antibody variable	16
small molecules	16
rbc antigens	16
clostridium botulinum	16
random coils	16
targeted delivery	16
national guidelines	16
clinically ill	16
cohort studies	16
mammary secretions	16
protective effects	16
prospective study	16
weeks later	16
standard serological	16
colorectal cancer	16
fluorescence microscopy	16
global health	16
assay results	16
disulfide bonds	16
medical doctors	16
less effective	16
positive patients	16
manufacturing process	16
higher doses	16
one hour	16
different routes	16
primer pairs	16
vaccinated individuals	16
igg concentrate	16
also examined	16
fresh platelets	15
electrical impedance	15
contamination risk	15
million inhabitants	15
results demonstrate	15
gpib expression	15
bacterial culture	15
months later	15
adenovirus type	15
detect antibodies	15
ub ml	15
human leukocyte	15
haemovigilance systems	15
external quality	15
vast majority	15
voluntary donors	15
useful tool	15
antibodies reactive	15
autologous haemotherapy	15
umbilical cord	15
immune tolerance	15
antibodies present	15
cell antibodies	15
comparing ffp	15
described elsewhere	15
fluorescent cells	15
membrane fusion	15
intrauterine transfusions	15
donor deferrals	15
may affect	15
yolk immunoglobulin	15
hcv antibody	15
much higher	15
maternal plasma	15
protein synthesis	15
igg level	15
serologic testing	15
quantum dot	15
done using	15
system antibodies	15
igg molecule	15
must also	15
plasma factors	15
highly immunogenic	15
treated patients	15
induced antibodies	15
atomic force	15
four hours	15
like antibodies	15
relative birth	15
denv infection	15
blood bags	15
local blood	15
plt transfusions	15
drug resistance	15
will lead	15
free haemoglobin	15
uremic syndrome	15
circulating immune	15
methods used	15
antibody isotype	15
functional antibody	15
considered positive	15
hours later	15
conjugated anti	15
epithelial cell	15
positive rate	15
immunogenic proteins	15
control bags	15
positive particles	15
regular donors	15
hour cci	15
multiple myeloma	15
clinical significance	15
trali cases	15
binding affinities	15
hcv ag	15
years period	15
random donors	15
serum ferritin	15
adoptive immunotherapy	15
cobe spectra	15
may induce	15
two human	15
rhd immunization	15
virulent rv	15
cell apheresis	15
alternative approach	15
aiha patients	15
secondary structure	15
final product	15
cd mab	15
immune checkpoint	15
heparin pf	15
binding domains	15
mica surface	15
hinge region	15
ip vs	15
laboratory mistake	15
plasma low	15
routinely used	15
human peripheral	15
mbl levels	15
hemagglutination inhibition	15
international standard	15
erythrocyte concentrates	15
ovarian cancer	15
spike antibody	15
neutralizing effects	15
detection system	15
proteins may	15
days later	15
viral titers	15
gene segments	15
pregnancy outcomes	15
immunized mice	15
newly emerging	15
rhd exons	15
case group	15
general hospitals	15
mcmv viral	15
standard deviation	15
rhd positive	15
th week	15
chronic fatigue	15
inhibitory fccriib	15
platelet function	15
spike glycoprotein	15
phage coat	15
low titer	15
mmr vaccination	15
like virus	15
ebov gp	15
hit patients	15
cardiac diseases	15
also important	15
neutralizing mab	15
emerging infections	15
sexual partners	15
infection may	15
cell yield	15
hematopoietic stem	15
new donors	15
fc effector	15
cold antibodies	15
derived platelets	15
clinical conditions	15
soluble protein	15
drug discovery	15
living space	15
apoplastic fluid	15
study included	15
health sciences	15
antibodies bound	15
salmonella enterica	15
blood derived	15
plasma volume	15
milk samples	15
low molecular	15
based assay	15
external controls	15
transient expression	15
early responders	15
dna typing	15
culture supernatants	15
antibody assays	15
rh system	15
receive blood	15
analytical sensitivity	15
treated platelets	15
antigen receptors	15
rare red	15
th response	15
human cytomegalovirus	15
serially diluted	15
cell adhesion	15
term newborns	15
group systems	15
platelet rich	15
rheumatic diseases	15
treated animals	15
human ig	15
quality controls	15
differences among	15
phage particle	15
also provide	15
type gp	15
rhd gene	15
prestorage leucodepletion	15
randomized trial	15
hbsag prevalence	15
platelet specific	15
steric hindrance	15
five patients	15
au nps	15
ii molecules	15
culture medium	15
hbsag negative	15
health problem	15
biologically active	15
type envelope	15
first report	15
viral safety	15
induced thrombocytopenia	15
flow rate	15
studies demonstrated	15
mds patients	15
alert system	15
auto vue	15
severe clinical	15
framework regions	15
transfusion institute	15
virus particle	15
cell disease	15
apheresis procedure	15
intestinal iga	15
synthetic dna	15
blood conservation	15
campylobacter jejuni	15
antigen antibody	15
simian immunodeficiency	15
successfully applied	15
pbs containing	15
pf antibody	15
chronic hepatitis	15
fresenius hemocare	15
rbc abs	15
humanized mab	15
hemocue plasma	15
fully synthetic	15
relatively small	15
maternal alloantibody	15
restrictive transfusion	15
results indicated	15
showed high	15
found positive	15
normal controls	15
whooping cough	14
different concentrations	14
donors will	14
inflammatory reactions	14
factor ix	14
may vary	14
mediated protection	14
quartz crystal	14
current study	14
constructed using	14
signaling pathways	14
engineered antibodies	14
iron deficiency	14
immune status	14
fatigue syndrome	14
botulinum toxin	14
therapeutic approaches	14
fluorescent antibody	14
statistical modelling	14
activating fc	14
response rate	14
antibody technology	14
large quantities	14
antigen complexes	14
using elisa	14
deuterium exchange	14
wide variety	14
clinical evaluation	14
conserved epitopes	14
one woman	14
human health	14
screening test	14
subacute sclerosing	14
ig preparations	14
chronic viral	14
sciences authority	14
cdrh identity	14
synergistic neutralizing	14
quantum dots	14
transfusion associated	14
chronic inflammatory	14
denv diii	14
higher concentration	14
therapeutic effects	14
body fluids	14
antigen units	14
i clinical	14
several weeks	14
cell killing	14
active sle	14
five days	14
also obtained	14
igg titers	14
therapeutic strategies	14
immune plasma	14
transfusion committee	14
partial protection	14
mediated lysis	14
aggregated igg	14
received blood	14
cell repertoire	14
human population	14
primary human	14
binding properties	14
generated using	14
regular blood	14
peer review	14
positive individuals	14
synthetic libraries	14
falciparum malaria	14
serologic assays	14
high titre	14
humoral responses	14
surface area	14
liver transplantation	14
transfusion strategy	14
immunoglobulin classes	14
pilot study	14
malaria infection	14
occurring antibodies	14
specific memory	14
cell counts	14
laboratory personnel	14
binding specificity	14
four years	14
pathological conditions	14
using recombinant	14
method using	14
cell development	14
iga deficiency	14
confer protection	14
serious complications	14
group antibodies	14
cohort study	14
specific serum	14
major cause	14
positive direct	14
future studies	14
particularly useful	14
secretory component	14
virus attachment	14
i trial	14
autoimmune haemolytic	14
antibody prophylaxis	14
local immunity	14
disease onset	14
passively acquired	14
purified using	14
patients showed	14
attenuated virus	14
reactive neutralizing	14
mab approved	14
new approach	14
falciparum antigens	14
elisa test	14
mice immunized	14
articular cartilage	14
clinical illness	14
compatibility testing	14
secreting cells	14
two samples	14
negative patients	14
young animals	14
antiviral antibodies	14
system may	14
response may	14
flow cytometer	14
infected dogs	14
graft versus	14
disease transmission	14
group antigen	14
previously infected	14
nzb mice	14
falciparum infection	14
active infection	14
functional activity	14
coat proteins	14
split intein	14
stimulating factor	14
several advantages	14
inhibitory receptors	14
vivo antibody	14
positive clones	14
million people	14
serum levels	14
immune phage	14
aqueous humor	14
diagnostic purposes	14
another important	14
sialic acid	14
following administration	14
viral protein	14
similar results	14
iga class	14
increasingly important	14
sandwich assay	14
bowel disease	14
plasma pools	14
protein binding	14
physical examination	14
kg body	14
transfusion process	14
extremely high	14
antibodies recognizing	14
antigen panning	14
bartonella spp	14
intravenous administration	14
acid residue	14
positive reaction	14
renal failure	14
second step	14
calf serum	14
normal subjects	14
cells will	14
like particle	14
cytopathic effects	14
highest dilution	14
overlapping epitopes	14
nobel prize	14
tested using	14
early phase	14
nucleotide sequences	14
antibody classes	14
neisseria meningitidis	14
merozoite surface	14
life threatening	14
basic research	14
hemolytic uremic	14
library constructed	14
immune deficiency	14
screening method	14
asian population	14
negative bacteria	14
haemovigilance programme	14
cell salvage	14
fv antibody	14
based methods	14
increasing number	14
antibody candidates	14
internal medicine	14
anaphylactic shock	14
secondary antibodies	14
cells per	14
hbsag positive	14
purified antibodies	14
standard deviations	14
acute lymphoblastic	14
binding activities	14
passively transferred	14
increased significantly	14
common variable	14
selected antibodies	14
bispecific igg	14
fungal infections	14
mrna encoding	14
forming units	14
nucleotide polymorphisms	13
fold higher	13
immune human	13
phosphate buffer	13
antibodies also	13
human memory	13
lymphoid tissue	13
paratope identity	13
facs screening	13
stx holotoxin	13
cell cytotoxicity	13
negative samples	13
rhd zygosity	13
intravenous injection	13
neonatal lupus	13
health authorities	13
acid amplification	13
insertional mutagenesis	13
helper cells	13
patient safety	13
broad neutralizing	13
neutrophil activation	13
donor platelet	13
neutralize sars	13
antibodies towards	13
based detection	13
cytomegalovirus infection	13
igy technology	13
paratope prediction	13
fusion partner	13
neonatal mice	13
frequency antigens	13
virus surface	13
soluble form	13
fecal samples	13
new insights	13
total igg	13
detect low	13
light microscopy	13
antigenic variation	13
widespread use	13
diagnostic tool	13
vital signs	13
infected targets	13
two categories	13
higher frequency	13
molecular basis	13
patient population	13
fi eld	13
made available	13
results demonstrated	13
prophylactic anti	13
chicken eggs	13
neutralization tests	13
received one	13
malignant cells	13
less likely	13
positive predictive	13
using anti	13
antibody reacted	13
phage displayed	13
shelf life	13
pulmonary disease	13
antibiotic resistance	13
lower levels	13
acute phase	13
term protection	13
directed mutagenesis	13
small intestine	13
corticosteroid therapy	13
clinical experience	13
human immunology	13
several days	13
overall mortality	13
highly purified	13
viral fusion	13
killed brv	13
modified mrna	13
cryptosporidium parvum	13
messenger rna	13
commercial kits	13
cell membranes	13
severe symptoms	13
transfusion practices	13
neonatal calf	13
fusion efficiency	13
terminal region	13
testing methods	13
mechanical ventilation	13
weight loss	13
several months	13
signal intensities	13
specific cytotoxic	13
certain cases	13
i antibodies	13
vaccine virus	13
medical research	13
selected clones	13
canine coronavirus	13
igm response	13
integral part	13
routine testing	13
expression systems	13
checkpoint inhibitors	13
specific immunity	13
skeletal muscle	13
recombinant dna	13
viral membrane	13
enzyme activity	13
taken place	13
cholera toxin	13
previously unknown	13
constant domain	13
ige binding	13
natural human	13
pcr method	13
cynomolgus macaques	13
adoptive transfer	13
elisa assay	13
receptor interactions	13
kg dose	13
igg class	13
laboratory tests	13
adv particles	13
heart block	13
five different	13
male patient	13
epitope sequence	13
tissue banking	13
macular degeneration	13
donor samples	13
antigenic targets	13
antiviral activity	13
antiviral responses	13
variable immunodeficiency	13
small cell	13
four times	13
mm nacl	13
cell patients	13
pathogenic bacteria	13
fluorescence intensity	13
induce antibodies	13
coagulation factor	13
st century	13
peritonitis virus	13
poly dat	13
blood inventory	13
tumor growth	13
studies performed	13
sars virus	13
ige antibodies	13
cell antibody	13
phosphate buffered	13
clinical data	13
fi lms	13
clinical presentation	13
sclerosing panencephalitis	13
antibody formation	13
bacterial species	13
healthy control	13
assay using	13
activate complement	13
protein engineering	13
virus may	13
per product	13
old female	13
lethal factor	13
severe hemolytic	13
effective way	13
miu ml	13
neutralization titers	13
repeat donors	13
mb plasma	13
longer periods	13
theraflex mb	13
one must	13
directed toward	13
us food	13
good manufacturing	13
determining region	13
vectored immunoprophylaxis	13
days since	13
plasma recipients	13
irregular antibodies	13
biomarker discovery	13