bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
ang ii	2108
converting enzyme	1202
angiotensin ii	885
angiotensin system	445
blood pressure	417
heart failure	360
ang i	360
angiotensin converting	250
ace inhibitors	247
acute respiratory	228
lung injury	223
amino acid	218
ace activity	214
ace expression	209
myocardial infarction	184
amino acids	177
mas receptor	177
ii type	170
angiotensin i	169
ace ang	165
type receptor	162
ace inhibitor	160
severe acute	148
respiratory syndrome	147
endothelial cells	146
ii receptor	138
ace inhibition	131
smooth muscle	129
cardiac hypertrophy	121
angiotensin receptor	120
spike protein	114
nitric oxide	111
acute lung	110
ii levels	109
mas axis	109
hypertensive rats	109
receptor blockers	106
epithelial cells	105
ace gene	104
growth factor	100
ace levels	100
sars coronavirus	98
respiratory distress	97
kidney disease	97
aldosterone system	96
gene expression	95
human ace	95
angiotensinconverting enzyme	94
oxidative stress	93
distress syndrome	89
diabetic nephropathy	89
mrna expression	88
coronavirus disease	85
muscle cells	82
ace protein	82
cardiovascular disease	82
left ventricular	81
angiotensin peptides	80
important role	79
novel coronavirus	76
cytokine storm	76
animal models	76
syndrome coronavirus	75
receptor mas	75
nervous system	74
spontaneously hypertensive	73
ang iv	73
cord uid	73
doc id	73
endothelial dysfunction	72
enzyme inhibition	71
transgenic mice	71
may also	71
human angiotensin	69
renin receptor	68
renin angiotensin	68
enzyme inhibitors	67
knockout mice	67
beneficial effects	65
protein expression	65
receptor antagonist	65
ang iii	64
mg kg	63
neutral endopeptidase	63
active site	62
induced cardiac	62
immune response	61
brain ras	61
inflammatory cytokines	60
angiotensin type	60
diabetes mellitus	60
related carboxypeptidase	59
clinical trials	59
ace may	58
induced lung	58
vascular endothelial	57
apelin ko	57
present study	56
blood flow	56
ko mice	56
cell proliferation	55
podocyte injury	55
coupled receptor	53
plasma levels	53
functional receptor	53
pulmonary hypertension	53
deficient mice	52
vascular smooth	52
ace mrna	52
necrosis factor	52
recombinant human	52
stem cells	51
protective effects	51
receptor antagonists	51
type diabetes	50
increased ace	50
cardiac function	49
receptor axis	49
crucial role	49
bone marrow	49
chronic kidney	47
cardiovascular diseases	47
heart function	47
nlrp inflammasome	46
viral entry	46
novel angiotensin	46
adipose tissue	46
tumor necrosis	46
endothelial cell	46
central nervous	46
mouse model	45
human heart	45
severe covid	45
plasma ang	45
biological activity	45
increased ang	43
lung tissue	43
inhibitor therapy	43
receptor blockade	43
cell surface	43
receptor blocker	43
cardiac dysfunction	43
protective role	42
enzyme activity	42
reninangiotensin system	42
therapeutic target	42
type i	41
host cells	41
kidney injury	40
enzyme inhibitor	40
ang tie	40
immune system	40
ii receptors	40
mineralocorticoid receptor	40
pregnant women	40
lung cancer	40
systematic review	39
ace angiotensin	39
cell growth	39
cell membrane	39
protein kinase	39
reactive oxygen	39
coronary artery	38
also known	38
previous studies	38
viral infection	38
cardiovascular system	38
cardiac remodeling	38
oxygen species	38
cell death	37
circulating ace	37
cell lines	37
solid phase	37
ii infusion	37
heart disease	37
high glucose	37
expression levels	37
ace deficiency	37
cardiac fibrosis	37
biologically active	37
inflammatory response	36
enzyme gene	36
blood vessels	36
cell entry	36
coronavirus infection	35
pulmonary arterial	35
vascular permeability	35
transforming growth	35
angiotensin iv	35
significantly increased	35
soluble ace	35
arterial hypertension	35
renin activity	34
protective effect	34
renal injury	34
signaling pathways	34
septic shock	34
clinical characteristics	34
ace knockout	34
mass spectrometry	34
binding domain	34
viral replication	34
functional expression	33
rats angiotensin	33
somatic ace	33
peptide synthesis	33
extracellular matrix	33
pressure overload	33
may contribute	33
converts angiotensin	33
disease severity	33
recombinant ace	33
ejection fraction	33
high levels	32
type ii	32
tissue distribution	32
binding site	32
significantly higher	32
potential therapeutic	32
several studies	32
cigarette smoke	32
gastrointestinal tract	32
cohort study	31
infected patients	31
local ras	31
insulin resistance	31
signal transduction	31
rat model	31
lung failure	31
plasma membrane	31
enzyme protects	30
endothelial function	30
cell volume	30
endothelial growth	30
nuclear factor	30
angiotensin peptide	30
hypertensive patients	30
receptor binding	30
increased expression	30
clinical studies	30
receptor activation	30
clinical trial	29
activated protein	29
transgenic rats	29
diabetic mice	29
ace ace	29
classical ras	29
increased levels	29
reduced ace	29
human homolog	29
proximal tubule	29
experimental models	29
ii formation	29
molecular mechanisms	29
plasma ace	29
receptor gene	29
side chain	29
enzymatic activity	29
ace receptor	29
dependent manner	29
first step	28
receptor ace	28
influenza virus	28
recent study	28
renal function	28
diabetic kidney	28
biological peptides	28
avian influenza	28
normal pregnancies	28
proximal tubules	28
enzyme angiotensin	28
cancer cells	28
congestive heart	28
significantly reduced	28
receptor stimulation	28
system inhibitors	28
pulmonary fibrosis	28
oxide synthase	27
catalytic activity	27
acid residues	27
lung fibrosis	27
cardiac myocytes	27
innate immune	27
inflammatory effects	27
critically ill	27
cleavage site	27
endogenous ligand	27
natriuretic peptide	27
pressure regulation	27
brain tissue	27
tie system	27
highly expressed	27
recent studies	26
essential hypertension	26
angiotensin receptors	26
deletion polymorphism	26
colitis severity	26
ectodomain shedding	26
per group	26
raas axis	26
severe cases	26
essential regulator	26
ace also	26
ras system	26
serum ace	26
neurogenic hypertension	26
molecular weight	26
serine protease	26
tissue injury	26
ii production	26
may lead	26
ras components	25
body weight	25
room temperature	25
renin inhibitors	25
induced hypertension	25
signaling pathway	25
cell types	25
protein levels	25
crystal structure	25
data suggest	25
ang peptides	25
null mice	25
chronic heart	25
renal disease	25
among patients	25
also found	24
novel therapeutic	24
renin inhibitor	24
pulmonary vascular	24
risk factors	24
alveolar epithelial	24
protease inhibitor	24
building blocks	24
western blot	24
mrna levels	24
ii signaling	24
liver fibrosis	24
lung tumor	24
glomerular filtration	24
cardiac fibroblasts	24
ii induces	24
organ damage	24
arterial pressure	24
control group	24
antimicrobial peptides	24
understanding sars	24
catalytic domain	24
ventrolateral medulla	23
ischemia reperfusion	23
cardiac angiotensin	23
active sites	23
artery disease	23
coronavirus spike	23
high blood	23
generate ang	23
vascular remodeling	23
adrenal gland	23
infected mice	23
retrospective cohort	23
cov infection	23
ventricular dysfunction	23
rights reserved	23
statistically significant	23
hepatic fibrosis	23
cellular hypertrophy	23
results showed	23
brain renin	23
raas components	23
prorenin receptor	23
cardiovascular effects	23
transcription factor	23
sars pathogenesis	23
high affinity	23
results suggest	23
receptor expression	23
proteolytic cleavage	22
treated mice	22
diabetic rats	22
spike glycoprotein	22
patients infected	22
statistical significance	22
clinical course	22
failing human	22
acute myocardial	22
side effects	22
plasma renin	22
receptor type	22
human renin	22
clinical outcomes	22
vitro studies	22
studies using	22
ventricular hypertrophy	22
previous study	22
critical role	22
lung diseases	22
immune responses	22
amyotrophic lateral	22
smoke exposure	22
ace ratio	22
united states	22
insensitive carboxypeptidase	22
lateral sclerosis	22
sympathetic nervous	21
hospitalized patients	21
rat brain	21
receptor subtypes	21
endoplasmic reticulum	21
uric acid	21
angiotensin iii	21
clinical evidence	21
severe pneumonia	21
reperfusion injury	21
circulating ang	21
catenin signaling	21
key role	21
inflammatory cytokine	21
significantly decreased	21
respiratory failure	21
ace shedding	21
signalling pathways	21
lung disease	21
cardiovascular function	21
ace overexpression	21
essential role	21
pathological conditions	21
liver disease	21
binding affinity	21
form ang	21
produce ang	21
innate immunity	21
adverse effects	20
inhibitory activity	20
gene transfer	20
like ace	20
induced acute	20
ace deletion	20
ace cleaves	20
tissue angiotensin	20
cancer cell	20
proximal tubular	20
ras activation	20
intensive care	20
potential role	20
human tissues	20
risk factor	20
human lung	20
enzyme type	20
hypertensive rat	20
spike proteins	20
central role	20
chain hetes	20
genetic deletion	20
classical raas	20
catalytically active	20
secondary structure	20
orally active	20
multiple comparisons	20
tissue damage	20
cytokine release	20
ii effects	19
virus infection	19
bovine serum	19
therapeutic targets	19
glomerular injury	19
mouse models	19
induced pulmonary	19
vascular inflammation	19
wt mice	19
previously described	19
gs bs	19
disease progression	19
bs type	19
first time	19
circulating ras	19
organ dysfunction	19
previously reported	19
exposed rats	19
significant differences	19
mice angiotensin	19
western blotting	19
mas receptors	19
patients treated	19
cellular ace	19
receptor subtype	19
significant difference	19
time pcr	19
well established	19
human coronavirus	19
cyclic peptides	19
may explain	19
taken together	19
receptor agonist	19
hypertension angiotensin	19
vascular endothelium	19
another study	19
angiotensin systems	19
ii treatment	19
physiological functions	19
like receptor	19
cell survival	19
insertion deletion	19
ii generation	18
platelet aggregation	18
viral rna	18
peptide analogues	18
cell type	18
endogenous ang	18
map kinase	18
mesangial cells	18
kinin system	18
peptide levels	18
plasminogen activator	18
proinflammatory cytokines	18
myocardial fibrosis	18
human airway	18
metabolic syndrome	18
homologue ace	18
may play	18
db db	18
urinary levels	18
cell apoptosis	18
treated group	18
target cells	18
normal lung	18
clinical data	18
also observed	18
dependent mechanism	18
rat heart	18
organ failure	18
active peptides	18
significantly different	18
induced diabetic	18
receptor angiotensin	18
ii stimulates	18
membrane fusion	18
healthy individuals	18
brain angiotensin	18
portal pressure	18
bs patients	18
isolated perfused	18
airway epithelial	17
serum ang	17
therapeutic potential	17
vasodilatory shock	17
authors declare	17
may increase	17
substrate specificity	17
antimicrobial activity	17
evidence suggests	17
antihypertensive effects	17
metabolic stability	17
coronavirus infections	17
brain barrier	17
aldosterone synthase	17
natriuretic peptides	17
bound ace	17
left ventricle	17
kidney diseases	17
tumor tissue	17
podocyte apoptosis	17
novel peptide	17
suppressed ang	17
control rats	17
soluble form	17
increased risk	17
plasma kallikrein	17
mice showed	17
db mice	17
injury angiotensin	17
transmembrane protein	17
performed using	17
acute kidney	17
circulating levels	17
type mice	17
mice lacking	17
acid transporter	17
protecting groups	17
analysis revealed	17
healthy controls	17
arb use	17
arachidonic acid	17
phase peptide	17
dawley rats	17
fold higher	17
detrimental effects	16
intestinal inflammation	16
two different	16
glomerular diseases	16
aldosterone secretion	16
adhesion molecules	16
ncov infection	16
deleterious effects	16
failure patients	16
ras blockade	16
inflammatory mediators	16
biological effects	16
cardioprotective effects	16
systolic blood	16
inflammatory responses	16
regulated aminopeptidase	16
higher risk	16
animal model	16
multiple organ	16
endogenous apelin	16
viral invasion	16
skeletal muscle	16
stem cell	16
human recombinant	16
side chains	16
complement system	16
tissue ras	16
tyrosine kinase	16
tubular cells	16
widely used	16
ras inhibitors	16
one study	16
significant reduction	16
losartan treatment	16
pivotal role	16
vascular resistance	16
type receptors	16
viral particles	16
wide variety	16
local renin	16
extracellular domain	16
ii ang	16
small intestine	16
ill patients	16
exogenous ang	16
neutral amino	16
renal angiotensin	16
drug design	16
increased blood	16
way anova	16
animal studies	15
pulmonary artery	15
respiratory system	15
generating ang	15
target organs	15
clinical features	15
serine proteases	15
cyclic peptide	15
decreased expression	15
solid support	15
based drug	15
may provide	15
ace null	15
ventricular tachycardia	15
ace might	15
inflammatory cells	15
cells angiotensin	15
adhesion molecule	15
care unit	15
renal ace	15
ace plays	15
atrial fibrillation	15
two active	15
serum levels	15
might also	15
also showed	15
cell adhesion	15
myocardial ischemia	15
vascular injury	15
molecular dynamics	15
mediates regulated	15
viral load	15
plasma angiotensin	15
masr axis	15
human cells	15
system blockers	15
ii stimulation	15
negative regulator	15
whereas ace	15
active renin	15
brush border	15
cardiac contractility	15
rat hearts	15
renal ang	15
peptide metabolism	15
higher levels	15
portal hypertension	15
peptide ang	15
cell signaling	15
ace concentration	15
subfornical organ	15
regulated ectodomain	15
basement membrane	15
activator inhibitor	15
pressure elevation	15
cardiomyocyte hypertrophy	14
viral infections	14
inflammatory drugs	14
normal pregnancy	14
lipid accumulation	14
i converting	14
mice per	14
host cell	14
binding sites	14
human podocytes	14
receptor signaling	14
also associated	14
whereas ang	14
study showed	14
ethics committee	14
cell culture	14
respiratory tract	14
daily i	14
expression profiling	14
cell viability	14
heart association	14
two peptides	14
ischaemic heart	14
new therapeutic	14
cells expressing	14
structural basis	14
increased angiotensin	14
genetic ace	14
vascular leakage	14
peptide angiotensin	14
chronic angiotensin	14
aldosterone levels	14
current evidence	14
converts ang	14
tumor cells	14
findings suggest	14
intracellular signaling	14
controlled trial	14
renin prorenin	14
extracellular signal	14
tissue factor	14
wide range	14
phase synthesis	14
circulating renin	14
middle east	14
immune cells	14
expressing cells	14
ace transgenic	14
analyzed using	14
urinary ace	14
ii accumulation	14
rat models	14
rostral ventrolateral	14
lung inflammation	14
heart rate	14
high concentrations	14
podocyte loss	14
experimental studies	14
ventricular remodeling	14
binding protein	14
new coronavirus	14
native peptide	14
major role	14
glucose transporter	13
ex vivo	13
new class	13
enzyme homologue	13
producing ang	13
progenitor cells	13
sga pregnancies	13
transcription factors	13
kinin peptides	13
low levels	13
knockout mouse	13
potent vasoconstrictor	13
cell rna	13
vascular dysfunction	13
tissue ang	13
ras activity	13
cell line	13
acid sequence	13
cardiac ace	13
tissue ace	13
vascular disease	13
different tissues	13
feedback loop	13
forming activity	13
density lipoprotein	13
cultured human	13
physiological roles	13
peptide sequence	13
metabolic alkalosis	13
gene polymorphisms	13
ii pneumocytes	13
ng ml	13
two main	13
disease control	13
chemoattractant protein	13
system angiotensin	13
juxtaglomerular cells	13
mast cell	13
measured using	13
bl mice	13
studies suggest	13
pressure control	13
arb therapy	13
sars virus	13
total rna	13
kidney damage	13
filtration barrier	13
type diabetic	13
local tissue	13
terminal domain	13
randomized controlled	13
plasma aldosterone	13
ii may	13
transmembrane domain	13
disulfide bridges	13
glomerular podocytes	13
significantly lower	13
receptors mediate	13
cardiac phenotype	13
resistant hypertension	13
beneficial effect	13
viral spike	13
studies showed	13
recently reported	13
hete metabolites	13
tissue kallikrein	13
sudden death	13
angiotensin aldosterone	13
engineered human	13
cd cd	13
gestational age	13
function angiotensin	13
entry receptor	13
increased plasma	13
hypertensive mice	13
east respiratory	13
growth factors	13
entry depends	12
systemic inflammation	12
liver injury	12
fatty acids	12
structural studies	12
controlled trials	12
sfrp expression	12
ros production	12
recombinant angiotensin	12
ras plays	12
cardiac tissue	12
protein synthesis	12
podocyte damage	12
complement cascade	12
receptor antagonism	12
tie signalling	12
coupled receptors	12
proteolytic activation	12
human plasma	12
significant role	12
renin gene	12
feb suppressed	12
hydrogen bond	12
adult inpatients	12
gene polymorphism	12
proven protease	12
metabolite formation	12
rat kidney	12
vasopressin release	12
acid transporters	12
liquid chromatography	12
blood coagulation	12
current study	12
may serve	12
acei arb	12
post hoc	12
cl cotransporter	12
like stem	12
activity relationship	12
protease tmprss	12
renal tubular	12
dependent hypertension	12
heart weight	12
membrane protein	12
murine model	12
induced cellular	12
commercially available	12
serum angiotensin	12
induced vascular	12
therapeutic strategies	12
well known	12
small embryonic	12
lung function	12
collecting duct	12
also shown	12
pulmonary diseases	12
particular interest	12
alpha convertase	12
interstitial fibrosis	12
aldosterone concentration	12
click chemistry	12
much higher	12
diabetic complications	12
critical illness	12
cellular receptor	12
immune complexes	12
decreased ang	12
ii also	12
dss i	12
pediatric patients	12
endothelial nitric	12
effects via	12
high concentration	12
ras axis	12
antihypertensive agents	12
clinically proven	12
inflammatory diseases	12
ii mediates	12
classical axis	12
cancer risk	12
american heart	12
mononuclear cells	12
inhibitor treatment	12
pathological changes	12
mouth disease	12
transmembrane protease	12
subsequent studies	12
therapeutic implications	12
may result	12
tissues using	12
renal fibrosis	12
mouse kidney	12
renal tubules	12
induced podocyte	12
chronic cigarette	12
pulmonary edema	12
creative commons	12
system blockade	12
ahf patients	12
failing heart	12
actin cytoskeleton	12
disease angiotensin	12
resveratrol alone	12
high risk	12
ace activation	11
cardiovascular physiology	11
birth weight	11
systemic ras	11
chain reaction	11
water retention	11
sex differences	11
intracellular signalling	11
determined using	11
cardiovascular actions	11
peptide bond	11
ms ms	11
single amino	11
elevated blood	11
assay kit	11
increases ace	11
elevated plasma	11
drug discovery	11
also promotes	11
selective inhibitors	11
cellular uptake	11
monocyte chemoattractant	11
two enzymes	11
expressing ace	11
ulcerative colitis	11
induced heart	11
dependent pathways	11
terminal catalytic	11
increased urinary	11
increased production	11
ii binds	11
human angiotensinconverting	11
lung damage	11
inhibit ace	11
following myocardial	11
arg bradykinin	11
expression may	11
transgenic mouse	11
therapeutic strategy	11
normal pregnant	11
atrial natriuretic	11
enzymerelated carboxypeptidase	11
nep may	11
structural proteins	11
therapeutic role	11
patients receiving	11
catenin pathway	11
even though	11
fetal bovine	11
expression level	11
muscle cell	11
specific inhibitors	11
clinical effects	11
sequence homology	11
cellular responses	11
ras pathway	11
kidney function	11
cord blood	11
increasing ace	11
gut dysbiosis	11
prostate cancer	11
negative feedback	11
converting enzymerelated	11
hypotensive effect	11
ventricular systolic	11
glomerular basement	11
therapeutic agents	11
cardiac ang	11
peptide fragments	11
alveolar macrophages	11
significant decrease	11
viral attachment	11
least two	11
brain regions	11
bioactive peptides	11
urinary excretion	11
human endothelial	11
molecular biology	11
biological functions	11
coronary arteries	11
via mas	11
research ethics	11
pressure responses	11
stranded rna	11
diminazene aceturate	11
cell membranes	11
failure angiotensin	11
amide bond	11
increase ace	11
multiple sclerosis	11
specific ace	11
blot analysis	11
terminal residue	11
tissue renin	11
possible role	11
infected cells	11
protein kinases	11
los niveles	11
akita mice	11
glycation end	11
carboxypeptidase angiotensin	11
fatty acid	11
high level	11
hematopoietic stem	11
human vascular	11
attenuates angiotensin	11
protein interactions	11
syncytial virus	11
healthy volunteers	11
degrades ang	11
pg ml	11
tissue levels	11
data indicate	11
higher concentrations	11
mas pathway	11
tumor growth	11
via angiotensin	11
phase ii	11
nucleus tractus	11
angiotensinogen gene	11
cellular levels	11
cardiovascular events	11
ii concentration	11
polymerase chain	11
supplementary material	11
many tissues	11
potential target	11
pulmonary disease	11
cardiac injury	11
increase ang	10
two distinct	10
important roles	10
significant increase	10
ang peptide	10
human kidney	10
commonly used	10
respiratory disease	10
induced tgf	10
neprilysin inhibitor	10
platelet activation	10
diabetic patients	10
breast cancer	10
functional groups	10
matrix proteins	10
active peptide	10
ace activators	10
harmful effects	10
increased activity	10
heart ventricles	10
better understanding	10
preserved ejection	10
inhibits growth	10
induced pah	10
tissue sites	10
informed consent	10
inhibitory effects	10
direct renin	10
binding proteins	10
pulmonary arteries	10
advanced glycation	10
wild type	10
factor receptor	10
chronic liver	10
aldosterone production	10
large number	10
may promote	10
emerging evidence	10
coronavirus nl	10
disease states	10
rheumatoid arthritis	10
blood pressures	10
colitis induction	10
results indicated	10
mechanical ventilation	10
forming enzymes	10
rodent models	10
renal perfusion	10
closely related	10
severe disease	10
potential treatment	10
intracellular calcium	10
myocardial injury	10
two isoforms	10
diabetic renal	10
ras may	10
enhanced expression	10
inhibitory effect	10
metabolic disorders	10
hypotensive effects	10
antithrombotic effect	10
angiotensinogen mrna	10
ace functions	10
inflammatory bowel	10
infection may	10
type angiotensin	10
mice treated	10
lipid metabolism	10
cardioprotective effect	10
venous thromboembolism	10
severe heart	10
mechanical stress	10
circular dichroism	10
foot processes	10
physiological conditions	10
peptide substrates	10
isolated rat	10
evidence indicates	10
renal failure	10
mesenchymal transition	10
ace polymorphisms	10
raas genes	10
widely expressed	10
short half	10
induced ace	10
formation rate	10
elevated ang	10
renal cortex	10
epithelial cell	10
amino group	10
may help	10
early stages	10
menstrual cycle	10
probably due	10
reduced renal	10
inhibition may	10
world health	10
glucose uptake	10
induced colitis	10
cardiovascular risk	10
pressure response	10
chemical synthesis	10
respiratory syncytial	10
mediated effects	10
data analysis	10
autoimmune diseases	10
alzheimer disease	10
influenza viruses	10
mediated reduction	10
health organization	10
paraventricular nucleus	10
european society	10
safety profile	10
direct effect	10
cells may	10
insulin sensitivity	10
sequence identity	10
structural analysis	10
also increased	10
nadph oxidase	10
analysis showed	10
sodium retention	10
terminal amino	10
ser thr	10
cleaves ang	10
soluble human	10
local angiotensin	10
ischemic stroke	10
cd cells	10
carboxyl group	10
renin receptors	10
electrolyte balance	10
inhibitor arb	10
perfused rat	10
lung adenocarcinoma	10
vascular complications	10
inflammatory factors	10
markedly increased	10
vascular beds	10
regulatory role	10
aortic smooth	10
circulating angiotensin	10
increasing evidence	10
whether ace	10
mortality rate	10
inhibitor binding	10
two axes	10
small molecule	10
chemical stability	10
aortic fibrosis	10
may cause	10
renoprotective effects	10
therapeutic benefits	10
virus entry	10
er stress	10
early gestation	9
induced aortic	9
gene family	9
porcine coronary	9
negatively charged	9
mm nacl	9
coronary heart	9
dipeptidyl carboxypeptidase	9
ii via	9
length human	9
precursor protein	9
gene encoding	9
related protein	9
plasma samples	9
statistical analysis	9
systolic dysfunction	9
hypertensive subjects	9
airway epithelia	9
signal peptide	9
catalytic efficiency	9
renal dysfunction	9
filtration rate	9
epicardial adipose	9
cell swelling	9
different organs	9
treated apelin	9
helical conformation	9
sympathetic nerve	9
soluble angiotensin	9
ace internalization	9
solitary tract	9
gene deletion	9
determine whether	9
santa cruz	9
antihypertensive drugs	9
heart block	9
end products	9
ii synthesis	9
endogenous angiotensin	9
future studies	9
acid residue	9
endosome system	9
human angiogenin	9
system components	9
predominantly expressed	9
therapeutic intervention	9
previous results	9
prolyl endopeptidase	9
ace contains	9
chain hete	9
renovascular hypertension	9
binding motif	9
new organ	9
beneficial role	9
ace function	9
using one	9
functional roles	9
peptide inhibitor	9
enzyme attenuates	9
recently described	9
specific cell	9
ras systems	9
pulmonary ras	9
protecting group	9
water transport	9
mice exhibit	9
fatal outcomes	9
antagonizes ang	9
ace activator	9
tubular epithelial	9
raas axes	9
provided evidence	9
sars receptor	9
clinical relevance	9
cell migration	9
higher plasma	9
correlated inversely	9
renal blood	9
cdna library	9
blood cells	9
clinical benefits	9
chronic ace	9
assay buffer	9
podocyte hypertrophy	9
lower ace	9
pathogenic avian	9
inflammatory lung	9
hfmd cases	9
myocardial remodeling	9
ace via	9
enzyme overexpression	9
critical care	9
foot process	9
including ace	9
normotensive rats	9
without affecting	9
accepted article	9
blood samples	9
right ventricular	9
acute phase	9
critical conditions	9
pathological findings	9
converting enzymes	9
highly specific	9
i receptor	9
human brain	9
convert ang	9
decreased ace	9
axis activation	9
infectious diseases	9
angiotensin generation	9
significantly inhibited	9
protective arm	9
mice show	9
activity assay	9
infarct size	9
vivo study	9
positively correlated	9
last decade	9
like receptors	9
myocardial ace	9
recombinant soluble	9
associated protein	9
th cells	9
peripheral blood	9
ii degradation	9
receptors may	9
treated rats	9
intrarenal renin	9
ang variants	9
apelin knockout	9
inhibitors may	9
cardiac effects	9
downregulate ace	9
conscious rats	9
gel electrophoresis	9
mm tris	9
fibrosis angiotensin	9
pathways angiotensin	9
decompensated heart	9
baroreflex sensitivity	9
experimental model	9
kg dose	9
new angiotensin	9
growth restriction	9
neprilysin inhibition	9
naturally occurring	9
inhibits angiotensin	9
local production	9
receptor knockout	9
salt hypertension	9
positive feedback	9
ii cell	9
ev infection	9
renal diseases	9
viral loads	9
pathological cardiac	9
alternative raas	9
epidermal growth	9
inflammatory reactions	9
connective tissue	9
evidence supports	9
reduced ang	9
may represent	9
newly synthesized	9
rat angiotensin	9
remains unclear	9
cigarette smoking	9
endothelial damage	9
apical surface	9
raas inhibitors	9
well tolerated	9
reach statistical	9
gene transcription	9
increased susceptibility	9
complement activation	9
biological properties	9
fractional shortening	9
coronavirus pneumonia	9
recent years	9
protein coupled	9
high ang	9
improves endothelial	9
cerebrospinal fluid	9
angiotensin metabolism	9
intracellular ang	9
cardiotoxic mid	9
activated ras	9
extracellular space	9
releasing peptide	9
inflammasome activation	9
downregulated connexins	9
arb treatment	9
pulmonary hypertensive	9
renin secretion	9
blood volume	9
randomized clinical	9
ion channels	9
elevated levels	9
rna expression	9
membrane bound	9
functional significance	9
mouse hearts	9
normal cardiac	9
regulates ace	9
expression via	9
terminal region	8
acid transport	8
transfected cells	8
drug development	8
hemodynamic effects	8
baroreceptor reflex	8
dipolar cycloaddition	8
mas proto	8
sympathetic activity	8
physiological role	8
cytokine production	8
ace insertion	8
activity ace	8
like growth	8
group showed	8
mediates angiotensin	8
lipoic acid	8
drugs targeting	8
peptide backbone	8
transduction mechanisms	8
quantitative mrna	8
proteolytic enzymes	8
novel homologue	8
severe hfmd	8
cardiovascular complications	8
chinese center	8
diseases angiotensin	8
study also	8
mesenchymal stem	8
adrenal glands	8
two homologous	8
specific receptor	8
mesenteric arteries	8
podocyte detachment	8
disulfide bonds	8
mental retardation	8
human umbilical	8
cardiac muscle	8
several reports	8
molecular modelling	8
levels may	8
eca en	8
factor alpha	8
peptide inhibitors	8
podocyte injuries	8
membranal ace	8
penetrating peptides	8
ace reduces	8
studies showing	8
opposite effects	8
plasma level	8
specific inhibitor	8
synthase inhibition	8
via activation	8
time points	8
male mice	8
also contribute	8
lupus nephritis	8
rat proximal	8
indel polymorphism	8
whether ang	8
bradykinin potentiation	8
highly pathogenic	8
myosin heavy	8
accentuates vascular	8
therapeutic options	8
inflammatory markers	8
organ dysfunctions	8
rho kinase	8
glomerular sclerosis	8
ii increases	8
might play	8
hoc test	8
apoe knockout	8
induced cell	8
higher expression	8
induced vasodilation	8
induce podocyte	8
murine vsels	8
oxide release	8
mrna level	8
national health	8
secreted frizzled	8
different cell	8
amyloid fibrils	8
ras cascade	8
transgenic animals	8
selective ace	8
nmr spectroscopy	8
hypertensive nephrosclerosis	8
catalytic properties	8
releasing hormone	8
blood vessel	8
buffered saline	8
upper respiratory	8
although ace	8
ii alone	8
pathway angiotensin	8
rat liver	8
also play	8
putative receptor	8
tertiary structure	8
monoclonal antibodies	8
peptide corresponding	8
fluid homeostasis	8
surface area	8
increased glomerular	8
specific amino	8
fetal growth	8
high mortality	8
enzyme accelerates	8
second messenger	8
antimicrobial peptide	8
organic solvents	8
adverse events	8
studies indicate	8
previously shown	8
regulated kinase	8
juxtaglomerular apparatus	8
ras within	8
disulfide bridge	8
tgn endosome	8
phase i	8
ii actions	8
findings indicate	8
del sraa	8
human disease	8
pressure effects	8
including hypertension	8
hepatic stellate	8
human liver	8
therapeutic approaches	8
dss treatment	8
ace i	8
mild cases	8
injury induced	8
pharmacological inhibition	8
ii induced	8
recent advances	8
vascular effects	8
kidney cortex	8
tumour necrosis	8
gut microbiome	8
patients admitted	8
neurodegenerative disorders	8
mediated increase	8
recent findings	8
kidney cells	8
pilot study	8
virus receptor	8
idiopathic pulmonary	8
grade soluble	8
hypertrophic markers	8
conformational analysis	8
fusion protein	8
study demonstrated	8
national institutes	8
altered blood	8
cell body	8
randomised trial	8
decreased levels	8
type internalization	8
clinical findings	8
tissue growth	8
ncov infected	8
ras inhibition	8
peptidyl dipeptidase	8
palmitic acid	8
systemic ang	8
map kinases	8
upregulate ace	8
hydrogen bonding	8
tau pathology	8
specific substrate	8
umbilical cord	8
membrane ace	8
cells transfected	8
cellular entry	8
ace converts	8
sodium pump	8
physiological function	8
testis ace	8
ace induces	8
new insights	8
mechanisms involved	8
life span	8
drosophila melanogaster	8
ace using	8
deficiency accentuates	8
protein level	8
bowel disease	8
northern italy	8
cov spike	8
ii angiotensin	8
ncov may	8
will allow	8
cells via	8
renin levels	8
patients showed	8
mice overexpressing	8
pathological effects	8
several new	8
clinical implications	8
alternative pathways	8
final concentration	8
pilot clinical	8
emerging role	8
described previously	8
fibrotic effects	8
ge healthcare	8
patients linked	8
ace concentrations	8
peptide dendrimers	8
either ace	8
vasoactive peptides	8
renal damage	8
nep expression	8
dysregulated ras	8
sars cov	8
xo expression	8
transmembrane serine	8
chronic obstructive	8
afferent arterioles	8
new target	8
electron microscopy	8
selective inhibitor	8
mediated activation	8
also called	8
apelin antagonizes	8
forming enzyme	8
therapeutic approach	8
prostaglandin synthesis	8
adverse outcomes	8
heavy chain	8
human vsels	8
also bind	8
renin expression	8
local ang	8
clinical use	8
using clinical	8
association study	8
mechanism underlying	8
ii activates	8
slit diaphragm	8
tumor angiogenesis	8
results suggested	8
pneumonia patients	8
axis may	8
descriptive study	8
trizol reagent	8
also expressed	8
reticulum stress	8
cell function	8
ii alveolar	8
main effector	8
endocrine system	8
ii level	8
macrophage infiltration	8
physiological effects	8
positively charged	8
forming ang	8
patients taking	8
markedly reduced	8
induced nephropathy	8
severe symptoms	8
ii metabolism	8
ace protects	8
tissue samples	8
disease pathogenesis	8
pressor response	8
receptor system	8
therapeutic agent	8
pathological remodeling	8
cardiac arrhythmias	8
germinal ace	8
new components	8
intracellular renin	8
diabetic retinopathy	8
biochemical indexes	8
activity relationships	8
xanthine oxidase	8
research council	7
ace results	7
life sciences	7
facilitates viral	7
iconverting enzyme	7
control mice	7
situ hybridization	7
may involve	7
without ace	7
interstitial fluid	7
two decades	7
opposing actions	7
ras might	7
randomized trial	7
american college	7
hypertension ace	7
kidney tissue	7
transcriptional regulation	7
experimental heart	7
monoclonal antibody	7
pulmonary blood	7
mice expressing	7
induced endothelial	7
new drugs	7
cardiovascular homeostasis	7
two separate	7
across gestation	7
media thickness	7
lung cells	7
antihypertensive effect	7
hexxh zinc	7
renal proximal	7
metabolic pathways	7
factor beta	7
artery smooth	7
lesser extent	7
treg th	7
diabetes infected	7
primary structure	7
specific ang	7
three different	7
yet known	7
small rnas	7
human tissue	7
coagulation cascade	7
kidney ace	7
direct evidence	7
reactive protein	7
early studies	7
transmembrane glycoprotein	7
chemical ligation	7
specific expression	7
alternative renin	7
proteins involved	7
furin cleavage	7
systemic blood	7
rat lung	7
cv system	7
catalytic domains	7
neutralizing antibodies	7
nonpeptide mimic	7
chloride channel	7
artery occlusion	7
type natriuretic	7
fat diet	7
mouse heart	7
large hinge	7
statistically significantly	7
amyloid angiopathy	7
inflammatory effect	7
serum albumin	7
ii blockade	7
using ace	7
ii exerts	7
adam activity	7
plaque formation	7
ras genes	7
well plates	7
increased cardiac	7
bradykinin peptides	7
infected pneumonia	7
studies revealed	7
healthy subjects	7
class i	7
peptide ligation	7
recent report	7
zinc metallopeptidase	7
novel human	7
pharmacokinetic properties	7
using trizol	7
drug candidates	7
pcr analysis	7
genetic analysis	7
dd genotype	7
molecular mechanism	7
confocal microscopy	7
endogenous peptide	7
cell activation	7
cerebral artery	7
inhibitors angiotensin	7
mediated vasodilation	7
unlike ace	7
derived tgf	7
cardiac renin	7
membrane aminopeptidase	7
lysis buffer	7
increased circulating	7
receptor mediates	7
negative bacteria	7
enzyme determines	7
unnatural amino	7
diseases including	7
proinflammatory cytokine	7
might contribute	7
mas angiotensin	7
research groups	7
processing enzymes	7
vascular tone	7
renal ras	7
underlying mechanisms	7
membranous nephropathy	7
potential mechanism	7
present work	7
enzymatic degradation	7
peptide libraries	7
different types	7
sprague dawley	7
ii administration	7
linear peptide	7
years ago	7
angiotensin angiotensin	7
human body	7
independent mechanisms	7
influenza infection	7
myocyte hypertrophy	7
apical membrane	7
obstructive pulmonary	7
reduced plasma	7
reduce ace	7
activity may	7
arterial remodeling	7
animal care	7
aldosterone release	7
albumin excretion	7
signal pathway	7
immunocytochemical expression	7
key regulator	7
wall thickness	7
normal human	7
may induce	7
rat lungs	7
damage caused	7
regulate ace	7
ventricular mass	7
survival study	7
adult tissues	7
baroreflex function	7
leading cause	7
antithrombotic activity	7
enzymatically active	7
pressure reduction	7
ray structures	7
lamina propria	7
nucleic acid	7
plasma clearance	7
ards induced	7
nmr studies	7
prospective study	7
since ang	7
mouse brain	7
antiproliferative activity	7
low doses	7
bnp mrna	7
experimental evidence	7
mouse embryonic	7
vitro study	7
cardioprotective actions	7
small molecules	7
diastolic dysfunction	7
white blood	7
study found	7
hfmd patients	7
chronic renal	7
prone spontaneously	7
systemic circulation	7
adult respiratory	7
lung tissues	7
also reported	7
feb administration	7
human blood	7
additional file	7
coronavirus sars	7
agonist ave	7
may act	7
i transmembrane	7
reduces blood	7
kinase pathway	7
ace differentially	7
apelin receptor	7
counterregulatory actions	7
proliferative effects	7
enhanced renal	7
human cardiac	7
ischemic cardiomyopathy	7
converting ang	7
angiotensin production	7
control study	7
mitochondrial dysfunction	7
studies also	7
disease model	7
circumventricular organs	7
ras blockers	7
bar chart	7
rat hypothalamo	7
enzyme inhibits	7
experimental colitis	7
molecular cloning	7
fluid balance	7
decrease ang	7
cardiac tissues	7
biological role	7
two amino	7
may attenuate	7
structures reveal	7
induces endothelial	7
biliary fibrosis	7
hemolytic activity	7
serum uric	7
potential mechanisms	7
cardiovascular regulation	7
endothelial ace	7
using lc	7
experimental acute	7
ii significantly	7
linked mental	7
abundantly expressed	7
pharmacological effects	7
muscle actin	7
express ace	7
pregnant rats	7
cardiovascular disorders	7
em structure	7
weight gain	7
inhibitor omapatrilat	7
pulmonary inflammation	7
vascular remodelling	7
peptidase activity	7
gene knockout	7
highest levels	7
reduced expression	7
renal renin	7
still unclear	7
heart cell	7
increase blood	7
hypertrophy induced	7
may exert	7
low molecular	7
pressure homeostasis	7
endothelial progenitor	7
oral administration	7
chronic hepatitis	7
cultured rat	7
myocardial hypertrophy	7
lactam bridge	7
zinc metallopeptidases	7
embryonic stem	7
ab operation	7
cell penetrating	7
excessive activation	7
sfrp overexpression	7
synthetic peptide	7
vasoactive peptide	7
peptide formation	7
subsequent study	7
improve outcomes	7
results obtained	7
middle cerebral	7
may reflect	7
aged apelin	7
renal ischemia	7
neurohypophysial system	7
mtt assay	7
takes place	7
neutralizing activity	7
blood sampling	7
different species	7
ace receptors	7
molecular basis	7
fold lower	7
dd polymorphism	7
inhibitors increase	7
shear stress	7
lipoprotein receptor	7
therapeutic effects	7
renal immunocytochemical	7
messenger rna	7
pulmonary injury	7
confidence interval	7
infarction increases	7
peptides containing	7
terminal dipeptide	7
producing fusion	7
i arbs	7
oral delivery	7
risk patients	7
human breast	7
microbial ecology	7
system activation	7
chart showing	7
kg day	7
also reduced	7
heart angiotensin	7
reproductive system	7
since ace	7
related proteins	7
bending motion	7
biological actions	7
ace homologue	7
ill covid	7
antiviral response	7
pulmonary ace	7
bat origin	7
also involved	7
evidence supporting	7
homologous domains	7
recently shown	7
mas knockout	7
china clinical	7
intravascular coagulation	7
cysteine protecting	7
relatively high	7
aspartic acid	7
differential expression	7
hospital admission	7
dependent vasodilatation	7
motion important	7
cleave ace	7
higher ace	7
potent inhibitor	7
polyclonal antibody	7
physiological relevance	7
fmoc tbu	7
important regulator	7
two forms	7
en pacientes	7
significant changes	7
higher ang	7
will discuss	7
mainly expressed	7
murine bone	7
ace variants	7
genomic characterization	7
renin release	7
lung edema	7
segmental glomerulosclerosis	7
prokaryotic selectivity	7
ace structure	7
peptide sequences	7
patients might	7
enzyme responsible	7
vascular diseases	7
via inhibition	7
strong evidence	6
urinary albumin	6
calcium signaling	6
mice exhibited	6
regulates blood	6
pulmonary inflammatory	6
stat pathway	6
particularly relevant	6
third trimester	6
molecular size	6
renin inhibition	6
inhibitor cocktail	6
derived vsels	6
measured per	6
causes severe	6
acid sequences	6
inhibitor mln	6
ii binding	6
outbreak associated	6
mediated pressor	6
canine coronary	6
human hearts	6
ii expression	6
steroidal anti	6
endogenous inhibitor	6
standard therapy	6
length form	6
downstream signalling	6
human genome	6
tractus solitarii	6
podocyte depletion	6
enzyme inhibitory	6
blood glucose	6
may offer	6
focal segmental	6
ncov spike	6
immunodeficiency virus	6
commons licence	6
ace substrate	6
results indicate	6
hydrolyzes ang	6
renal cells	6
month exposed	6
altered glycosylation	6
sars outbreak	6
much less	6
structure analysis	6
bovine aortic	6
central angiotensin	6
new potential	6
specific angiotensin	6
increasing local	6
heart contractility	6
chronic administration	6
degrading ang	6
cell biology	6
acid release	6
spinal cord	6
tissues including	6
surface receptors	6
conformational change	6
study using	6
virus transmission	6
factor kappa	6
potent anti	6
may affect	6
mediated cardiac	6
effects mediated	6
spike receptor	6
reduced left	6
human research	6
mechanisms regulating	6
induced injury	6
mediated ace	6
myocardial infarcted	6
case report	6
immune complex	6
vasopeptidase inhibition	6
low concentration	6
receptors form	6
potential approach	6
nep levels	6
poorly understood	6
baroreflex control	6
female reproductive	6
ncov sars	6
cotransporter activity	6
vascular cells	6
experimental hypertension	6
peptide chain	6
insulin secretion	6
hypoxic pulmonary	6
gram positive	6
remain unclear	6
cerebral amyloid	6
research group	6
ace leads	6
sars patients	6
hospitalized covid	6
drug administration	6
fibroblast proliferation	6
possible involvement	6
thrombus formation	6
ad compared	6
calculated using	6
adrenergic receptor	6
controlled study	6
weight ratio	6
cardiac output	6
arb drugs	6
collagen synthesis	6
ace acts	6
system date	6
human subjects	6
dimensional structure	6
active ace	6
target organ	6
promotes antithrombotic	6
gastric cancer	6
large body	6
elevated ace	6
acute cardiac	6
subsequent ang	6
general hospital	6
protease inhibitors	6
low dose	6
signaling mechanisms	6
intracellular angiotensin	6
will present	6
turn structure	6
combined treatment	6
financial support	6
also confirmed	6
cells within	6
caudal ventrolateral	6
dna sequences	6
ace amplification	6
peptide receptor	6
vivo metabolism	6
complex system	6
nonproteolytic activation	6
alternative pathway	6
podocytes cultured	6
differentially interact	6
selective overexpression	6
vehicle treatment	6
protective ang	6
shr kidney	6
perivascular fibrosis	6
vasopeptidase inhibitors	6
human urine	6
bradykinin receptor	6
microwave irradiation	6
disseminated intravascular	6
rna virus	6
terminal glycosylation	6
renal impairment	6
organ injury	6
vasoprotective axis	6
sectional area	6
colitis model	6
using different	6
expressed ace	6
trend towards	6
associated coronavirus	6
ace level	6
specific tissues	6
specific protein	6
vasopeptidase inhibitor	6
biochemical pathways	6
month smoke	6
reduced levels	6
viral shedding	6
kinin peptide	6
severe respiratory	6
supplementary table	6
rats reduces	6
nucleic acids	6
biological evaluation	6
pediatric kidney	6
egf receptor	6
shed light	6
rats treated	6
might provide	6
canonical wnt	6
another important	6
clinical manifestations	6
pe group	6
novel target	6
single residue	6
glomerular podocyte	6
alternative axis	6
arterial blood	6
cardiovascular pathologies	6
chronic inflammation	6
activity studies	6
truncated form	6
genetic variants	6
animal experiments	6
termed ace	6
weight kininogen	6
mainly due	6
augments entry	6
use committee	6
digestive system	6
significantly elevated	6
systemic vascular	6
coronavirus replication	6
proximal straight	6
specific binding	6
bradykinin peptide	6
findings support	6
pyrococcus furiosus	6
enhanced chemiluminescence	6
two groups	6
last years	6
una mayor	6
brain ace	6
mediated relaxation	6
isolated using	6
collagen iii	6
acute renal	6
regulate blood	6
nonpeptide angiotensin	6
early stage	6
randomised controlled	6
different populations	6
extracellular fluid	6
also induce	6
water absorption	6
acute coronary	6
amino terminal	6
potent inhibitors	6
cirrhotic patients	6
limiting step	6
acid peptide	6
human glomerular	6
higher doses	6
hw bw	6
helical structure	6
mg day	6
long time	6
accumulating evidence	6
intrarenal angiotensin	6
activation via	6
serial changes	6
fold increase	6
thick ascending	6
water reabsorption	6
cell cycle	6
enhanced ang	6
dendritic cells	6
gut microbiota	6
total protein	6
new analogues	6
chronic treatment	6
atp ap	6
attenuates pulmonary	6
collagen deposition	6
signaling molecules	6
accessory proteins	6
protein priming	6
peptides derived	6
increased mortality	6
osmotic minipumps	6
downstream signaling	6
important mechanism	6
entry driven	6
increased serum	6
lv ejection	6
trna fragments	6
three main	6
days post	6
mas oncogene	6
lewis rats	6
nucleotide polymorphisms	6
improved metabolic	6
transgenic ren	6
adult patients	6
previous reports	6
membrane vesicles	6
oncogene mas	6
regulated membrane	6
many questions	6
considered significant	6
enzyme activators	6
study reported	6
ii feb	6
anova followed	6
developmentally regulated	6
full length	6
murine recombinant	6
fluid volume	6
key enzyme	6
act via	6
induced hypertensive	6
xo activity	6
ras peptides	6
renal tissue	6
resveratrol protects	6
several different	6
phase method	6
mice carrying	6
severe coronavirus	6
van der	6
glial cells	6
promising candidates	6
university hospital	6
several mechanisms	6
blood cell	6
two independent	6
positive bacteria	6
plasma volume	6
also increases	6
host immune	6
considered statistically	6
trypsin inhibitor	6
hydroxyeicosatetraenoic acid	6
remains elusive	6
pneumonia outbreak	6
directed mutagenesis	6
inflammatory conditions	6
tract infections	6
sodium excretion	6
dna gyrase	6
microvascular endothelial	6
sickle cell	6
vivo heart	6
actions via	6
derived peptides	6
enzyme levels	6
nasal epithelium	6
lcz group	6
previously demonstrated	6
mesenchymal cells	6
antifibrotic effects	6
components required	6
leukocyte recruitment	6
dp dt	6
new roles	6
hypertension hospitalized	6
probable bat	6
wistar rats	6
prevent lung	6
natural amino	6
system revisited	6
regulated kinases	6
tissue inflammation	6
renal effects	6
human pulmonary	6
fibrosis induced	6
distinct roles	6
receptor mrna	6
mhc ratio	6
negatively regulates	6
ace cleavage	6
kininase ii	6
higher affinity	6
acid aspiration	6
induced obesity	6
terminal active	6
ischaemic stroke	6
stellate cells	6
pulmonary angiotensin	6
rat aorta	6
concentration increases	6
native chemical	6
ace antibody	6
vasodepressor actions	6
dna synthesis	6
renal tissues	6
wnt signaling	6
african americans	6
receptor recognition	6
vascular events	6
also express	6
drugs may	6
newly discovered	6
ut mice	6
key step	6
virus replication	6
ii antagonism	6
peptide chains	6
normal conditions	6
recent meta	6
vascular cell	6
atpase activity	6
take place	6
losartan administration	6
chain cyclization	6
receptor mediated	6
lead compounds	6
arterial stiffness	6
hydrophobic interactions	6
patients requiring	6
neprilysin inhibitors	6
clinical outcome	6
camostat mesylate	6
artery remodeling	6
mechanism involving	6
membrane proteins	6
rats exposed	6
possible mechanisms	6
increased renal	6
expression analysis	6
intestinal ace	6
results may	6
synthetic peptides	6
key factor	6
rat uterus	6
hemoregulatory peptide	6
glucose transport	6
also demonstrated	6
prorenin levels	6
hela cells	6
induces vascular	6
many different	6
cardiopulmonary protection	6
cells express	6
shr rats	6
also present	6
high molecular	6
ii regulates	6
mas expression	6
pathological hypertrophy	6
provide evidence	6
written informed	6
viral binding	6
lung epithelial	6
clinical practice	6
pregnancy group	6
rat aortic	6
investigate whether	6