trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
acute lung injury	616
respiratory distress syndrome	346
acute respiratory distress	324
in patients with	212
in the lung	174
as well as	161
the development of	142
lung injury in	128
induced lung injury	117
of acute lung	112
of patients with	112
the expression of	102
the role of	101
induced acute lung	100
is associated with	99
in acute lung	98
the use of	96
lung injury and	92
the pathogenesis of	89
the presence of	85
acute respiratory failure	82
intensive care unit	81
critically ill patients	81
in the lungs	79
of ali ards	77
of acute respiratory	77
the number of	76
the acute respiratory	76
the effect of	74
the control group	71
i r injury	70
liver i r	70
involved in the	70
role in the	69
of lung injury	69
in ali ards	67
according to the	66
the treatment of	66
patients with ali	66
patients with acute	64
in the pathogenesis	64
mesenchymal stem cells	64
in critically ill	64
tumor necrosis factor	63
in response to	62
of the lung	62
the severity of	62
one of the	61
in this study	61
the lung tissue	60
a total of	58
the levels of	57
the production of	56
been shown to	55
and acute respiratory	55
the activation of	54
length of stay	53
patients with ards	52
patients with severe	52
study was to	52
the effects of	52
vascular endothelial growth	51
of the patients	51
the present study	50
was used to	50
endothelial growth factor	50
a number of	49
of mechanical ventilation	49
the intensive care	48
associated with the	48
severe acute respiratory	48
in the alveolar	48
compared to the	48
there was no	47
this study was	46
of this study	46
pathogenesis of ali	46
acute respiratory syndrome	45
h after lps	44
with acute respiratory	44
the aim of	44
the lungs of	43
due to the	43
an important role	43
alveolar epithelial cells	42
in the development	42
important role in	41
compared with the	41
to evaluate the	41
as shown in	41
at h after	41
in addition to	41
it has been	41
the level of	41
in the icu	41
stem progenitor cells	41
in order to	40
airway epithelial cells	40
to assess the	40
are associated with	40
based on the	40
was associated with	39
we found that	38
for the treatment	38
patients in the	37
has been shown	37
with ali ards	37
associated with increased	37
injury in mice	36
and septic shock	36
is the most	36
the release of	35
to determine the	35
associated with a	35
for ali ards	35
to the icu	34
development of ali	34
the most common	34
activation of the	34
mechanically ventilated patients	34
with severe sepsis	34
what is the	34
bronchoalveolar lavage fluid	34
respiratory syndrome coronavirus	33
in the first	33
there was a	33
injury induced by	33
extended data fig	33
cells in the	33
on the other	33
cm h o	33
after liver i	33
lung tissues were	33
there were no	33
the pathophysiology of	33
have shown that	33
of aec s	33
apache ii score	33
ali ards patients	33
in the lps	32
organoids derived from	32
be associated with	32
is characterized by	32
showed that the	32
mouse model of	32
admitted to the	32
after lps administration	32
for acute lung	32
patients admitted to	32
well as the	31
the other hand	31
the inflammatory response	31
aim of this	31
lung inflammation and	31
understanding of the	31
the incidence of	31
as compared with	30
of the disease	30
of c a	29
the impact of	29
were included in	29
were used to	29
the mice were	29
activated protein kinase	29
and in the	29
expression in the	29
the risk of	29
nitric oxide synthase	29
as previously described	29
the lung tissues	28
ttp ko mice	28
related to the	28
lung injury induced	28
downregulation of palm	28
expression of the	28
patients were included	28
stem cells in	28
in the control	28
changes in the	28
in animal models	28
lung epithelial cells	28
can be used	27
the study was	27
for treatment of	27
for patients with	27
the need for	27
the most likely	27
adult respiratory distress	27
with septic shock	27
at room temperature	27
the alveolar space	27
observed in the	27
of the study	27
as compared to	27
in acute respiratory	27
in terms of	27
in the presence	27
the noninfluenza group	26
of ali and	26
differentially expressed genes	26
the formation of	26
was significantly higher	26
no significant differences	26
and the acute	26
patients with sepsis	26
the regulation of	26
severe sepsis and	26
the absence of	25
challenged ttp ko	25
was performed using	25
from patients with	25
a variety of	25
injury and the	25
sepsis and septic	25
in lung tissues	25
intensive care units	25
data suggest that	25
to investigate the	25
the degree of	25
murine model of	25
to the lung	25
a mouse model	25
found that the	25
lung injury by	24
of p x	24
in the balf	24
the two groups	24
induced by lps	24
the management of	24
the application of	24
has been reported	24
model of ali	24
there is a	24
in the intensive	24
with acute lung	24
a role in	24
of severe sepsis	24
influenza a virus	24
the downregulation of	24
the end of	24
ttp are mice	24
the authors declare	24
mesenchymal stem cell	24
analysis was performed	24
ali and ards	24
duration of mechanical	24
respiratory failure in	24
endothelial cell barrier	24
to be a	24
contribute to the	24
morbidity and mortality	23
results suggest that	23
be used to	23
in the ad	23
has also been	23
s p receptor	23
in the ali	23
between the two	23
an increase in	23
the first h	23
patients at risk	23
animal models of	23
were analyzed by	23
the h n	23
in bronchoalveolar lavage	23
tlr and tlr	23
to the development	23
injury in rats	23
a murine model	23
found to be	23
has not been	23
reactive oxygen species	23
most likely diagnosis	23
in intensive care	23
of the alveolar	22
levels in the	22
and h after	22
in a murine	22
is one of	22
in the h	22
activated protein c	22
pulmonary vascular permeability	22
in accordance with	22
shown in fig	22
was used for	22
myosin light chain	22
in a mouse	22
the ability of	22
injury and acute	22
in the treatment	22
appears to be	22
to the control	22
of inflammatory mediators	22
analysis showed that	22
the alveolar epithelium	22
negative regulator of	22
of ttp in	22
alveolar fluid clearance	22
organoids can be	22
mortality in patients	22
of proinflammatory cytokines	22
results showed that	22
been associated with	22
h n influenza	21
when compared to	21
chronic obstructive pulmonary	21
used as a	21
in the noninfluenza	21
associated with higher	21
ali ards is	21
the rate of	21
lung tissue from	21
were treated with	21
was used as	21
the function of	21
keratinocyte growth factor	21
the majority of	21
there is no	21
can also be	21
increased risk of	21
our understanding of	21
the lung injury	21
of the most	21
included in the	21
a model of	21
is involved in	21
regulation of the	21
in the present	21
of s p	21
hepatocyte growth factor	21
in the pulmonary	20
and treatment of	20
that in the	20
a critical role	20
and outcomes of	20
a period of	20
pluripotent stem cells	20
as a potential	20
light chain kinase	20
genetic association studies	20
in the study	20
is an important	20
after lps challenge	20
likely to be	20
have been shown	20
as determined by	20
treatment of acute	20
and lung injury	20
macrophage migration inhibitory	20
of the human	20
obstructive pulmonary disease	20
migration inhibitory factor	20
may be a	20
type ii cells	20
model of acute	20
in lung tissue	20
of the gene	20
than in the	20
gene coding for	20
risk factors for	20
admission to the	20
in lung injury	20
to study the	20
demonstrated that the	20
leads to the	20
of icu stay	19
significantly higher in	19
plays an important	19
studies have demonstrated	19
patients with the	19
ali induced by	19
western blot analysis	19
the identification of	19
were incubated with	19
infl uence the	19
a rat model	19
polymorphisms in the	19
analysis of the	19
this patient has	19
the influence of	19
and outcome of	19
the onset of	19
with or without	19
of respiratory failure	19
the current study	19
approved by the	19
is essential for	19
in adults with	19
the importance of	19
and activation of	19
to be associated	19
was observed in	19
the mechanism of	19
this article is	19
p map kinase	19
the loss of	19
the gene coding	19
the inhibition of	18
for mechanical ventilation	18
and outcome in	18
n a l	18
icu and hospital	18
of nebulised heparin	18
shown to be	18
patients with septic	18
a l p	18
ligation and puncture	18
in the setting	18
responsible for the	18
the extent of	18
and inflammation in	18
after acute lung	18
region of the	18
treatment of ali	18
the setting of	18
to the lungs	18
as a result	18
the percentage of	18
challenged ttp are	18
and mechanical ventilation	18
the lps group	18
care and use	18
the time of	18
risk of death	18
need to be	18
were found to	18
were subjected to	18
models of ali	18
no difference in	18
these data suggest	18
the adult respiratory	18
high levels of	18
end of the	18
shown in table	18
was supported by	18
the bone marrow	18
protective effects of	18
be involved in	18
the case of	18
of septic shock	18
the lung is	18
in the case	18
in the early	18
studies have shown	18
in the regulation	18
critical role in	18
human airway epithelial	18
the basis of	18
the outcome of	18
inducible nitric oxide	18
the administration of	18
a significant increase	18
is likely to	17
l p r	17
and mg kg	17
have demonstrated that	17
p r o	17
of these patients	17
self assessment questions	17
higher in the	17
acute kidney injury	17
a systematic review	17
the association between	17
a part of	17
referred to as	17
o u r	17
u r n	17
such as the	17
of vascular endothelial	17
associated with susceptibility	17
smooth muscle cells	17
response to lps	17
we hypothesized that	17
the relationship between	17
inflammatory lung injury	17
i r group	17
patients who were	17
was found to	17
h n group	17
the changes in	17
ill patients with	17
respiratory failure and	17
of inflammatory cytokines	17
in the acute	17
previous studies have	17
role of the	17
levels of tnf	17
development of acute	17
cecal ligation and	17
p r e	17
for h at	17
j o u	17
patients infected with	17
alveolar type ii	17
increased levels of	17
of tumor necrosis	17
the results of	17
o o f	17
r o o	17
associated with ali	17
r n a	17
systemic inflammatory response	17
at the end	17
these results suggest	17
derived stem cells	17
of pulmonary edema	17
are expressed as	17
was determined by	17
the oleic acid	16
mortality in the	16
expression in lung	16
assessment questions in	16
differences in the	16
conflict of interest	16
ventilated patients with	16
evidence suggests that	16
article is protected	16
red blood cells	16
of severe acute	16
of inflammatory cells	16
h n virus	16
of sepsis and	16
airway epithelial cell	16
protected by copyright	16
lung injury date	16
and mortality in	16
in septic shock	16
a reduction in	16
in ards patients	16
clinical isolates of	16
levels of il	16
mechanical ventilation in	16
the process of	16
and acute lung	16
not associated with	16
increase in the	16
to identify the	16
for min at	16
the lung was	16
suggest that the	16
is protected by	16
the diagnosis of	16
the mechanisms of	16
in both groups	16
in a rat	16
epithelial cells and	16
h after liver	16
gene expression in	16
used in the	16
questions in rheumatology	16
cytokines and chemokines	16
authors declare that	16
have also been	16
the most important	16
consistent with the	16
because of the	15
of stay in	15
data are expressed	15
were used as	15
c bl mice	15
effects of curcumin	15
challenged ttp myeko	15
inhibition of the	15
the occurrence of	15
for the development	15
is regulated by	15
this suggests that	15
the ability to	15
the combination of	15
plasminogen activator inhibitor	15
respiratory syncytial virus	15
fluid clearance in	15
induced ali in	15
in critical care	15
oxidative stress and	15
all the patients	15
the association of	15
nlrp inflammasome activation	15
analysis of variance	15
compared with those	15
septic shock and	15
multiple organ dysfunction	15
in the serum	15
before and after	15
in mechanically ventilated	15
cystic fi brosis	15
significant differences in	15
length of icu	15
associated with an	15
host immune response	15
was induced by	15
injury caused by	15
were associated with	15
stem cells and	15
which in turn	15
in patients who	15
a negative regulator	15
outcomes of acute	15
the increase in	15
lung injury the	15
in comparison to	15
been reported to	15
stem progenitor cell	15
in our study	15
acute renal failure	15
a role for	15
inflammatory response in	15
idiopathic pulmonary fibrosis	15
intercellular adhesion molecule	15
protective effect of	15
have been described	15
acute lung inflammation	15
in alveolar macrophages	15
significant increase in	15
oleic acid group	15
play a role	14
the proliferation of	14
the efficacy of	14
extracorporeal membrane oxygenation	14
middle east respiratory	14
accordance with the	14
east respiratory syndrome	14
shirato et al	14
in recent years	14
play an important	14
part of springer	14
thermo fisher scientific	14
of the na	14
the study of	14
did not have	14
the membranes were	14
resulted in a	14
are presented as	14
the nlrp inflammasome	14
icu length of	14
invasive mechanical ventilation	14
in survivors of	14
clinical characteristics of	14
endothelial and epithelial	14
we did not	14
severity of the	14
described in the	14
of vegf in	14
total of patients	14
mechanical ventilation and	14
is a common	14
associated lung injury	14
therapeutic potential of	14
were admitted to	14
was assessed by	14
considered to be	14
days after discharge	14
h after the	14
innate immune responses	14
admitted to our	14
results indicate that	14
pathways involved in	14
inflammatory cytokines and	14
the susceptibility to	14
with h n	14
in contrast to	14
the amount of	14
increased vascular permeability	14
is required for	14
in bal fluid	14
isolates of hcov	14
in the pathophysiology	14
used for the	14
induced ali and	14
epithelial and endothelial	14
in the management	14
is a major	14
part of the	14
injury in the	14
a recent study	14
dead space fraction	14
science business media	14
the patients were	14
most of the	14
is due to	14
aim of the	14
distress syndrome in	14
incidence and outcomes	14
results in the	14
the course of	14
difference in the	14
of inflammation and	14
springer science business	14
derived from the	14
the rd day	14
the duration of	14
in the past	14
of springer science	14
there are no	14
the lungs were	14
by means of	14
in the current	14
no significant difference	14
mobility group box	13
of alveolar macrophages	13
in each group	13
all rights reserved	13
during the first	13
the innate immune	13
severity of lung	13
risk of developing	13
with respect to	13
linked immunosorbent assay	13
granule content and	13
the results showed	13
components of the	13
ali or ards	13
mean age of	13
of intensive care	13
the icu stay	13
obtained from the	13
adult patients with	13
to explore the	13
neutrophil extracellular traps	13
pao fio ratio	13
for acute respiratory	13
each time point	13
with a high	13
patients admitted in	13
and length of	13
of palm on	13
of the inflammatory	13
like receptor signaling	13
of patients were	13
leading to the	13
due to a	13
national institutes of	13
they have no	13
zt and zt	13
was no difference	13
intratracheal administration of	13
response to the	13
it is important	13
by highly pathogenic	13
at risk for	13
a result of	13
ali in mice	13
in vitro and	13
lung tissue was	13
logistic regression analysis	13
of cytokine signaling	13
were obtained from	13
well as in	13
rat model of	13
proliferation of aec	13
was to evaluate	13
to acute lung	13
induced pluripotent stem	13
in the mouse	13
molecular mechanisms of	13
vascular endothelial cells	13
after lps stimulation	13
when compared with	13
similar to the	13
were no significant	13
group of patients	13
to be an	13
the interaction of	13
acute exacerbation of	13
of melatonin in	13
were higher in	13
the study period	13
exacerbation of copd	13
as described in	13
of the respiratory	13
plasma levels of	13
are involved in	13
is responsible for	13
the cells were	13
declare that they	13
was performed by	13
at each time	13
the activity of	13
and in vivo	13
in of the	13
dry weight ratio	13
to reduce the	13
the lack of	13
was obtained from	13
innate immune response	13
were found in	13
this is a	13
were performed using	13
on acute lung	13
the purpose of	13
the first days	13
patients were admitted	13
human pulmonary microvascular	13
that they have	13
was confirmed by	13
which has been	13
is important to	13
the in vivo	13
at the time	13
the in vitro	13
the cell surface	12
a central role	12
no differences in	12
is the first	12
susceptibility and outcome	12
roles in the	12
in the gene	12
expressed in the	12
and release of	12
study of patients	12
were observed in	12
significant differences between	12
of critically ill	12
inflammation in the	12
be used for	12
of the right	12
of gene expression	12
lung injury caused	12
ii and sofa	12
are needed to	12
of death in	12
disorders such as	12
to have a	12
within the first	12
aspiration of gastric	12
in the number	12
a member of	12
the potential to	12
vivo and in	12
no conflict of	12
distress syndrome the	12
the risk factors	12
lower in the	12
remains to be	12
lung injury was	12
has been associated	12
in septic patients	12
associated with acute	12
a decrease in	12
of oxymatrine on	12
effect of oxymatrine	12
review and meta	12
ali susceptibility and	12
mortality rate was	12
that can be	12
of the acute	12
elevated levels of	12
is mediated by	12
inflammatory response and	12
of ali in	12
admitted to icu	12
infl ammatory response	12
depending on the	12
in vivo and	12
of endothelial cell	12
of ards in	12
reported to be	12
susceptibility and or	12
depends on the	12
applied to the	12
use of a	12
balb c mice	12
proximal and distal	12
statistical analysis was	12
of patients admitted	12
significantly lower in	12
derived mesenchymal stem	12
may lead to	12
hematoxylin and eosin	12
microvascular endothelial cells	12
compared to lps	12
the length of	12
were purchased from	12
arterial blood gas	12
of bone marrow	12
detected in the	12
renal replacement therapy	12
analyses were performed	12
in sepsis and	12
lung injury after	12
cells via the	12
many of the	12
the mortality rate	12
in the circulation	12
more than one	12
with high mortality	12
of the il	12
of hepcidin in	12
was approved by	12
induced by lipopolysaccharide	12
to the intensive	12
on the basis	12
significantly higher than	12
administration of lps	12
the therapeutic potential	12
systematic review and	12
in the same	12
in ali and	12
the bronchoalveolar lavage	12
expression levels of	12
compared with controls	12
of the cell	12
polymerase chain reaction	12
prospective observational study	12
found in the	12
the human lung	12
which can be	12
the disease is	12
a key role	12
diffuse alveolar damage	12
transepithelial sodium transport	12
apache ii and	12
with the development	12
with a median	12
have been reported	12
quality of life	12
of gastric contents	12
was significantly reduced	12
in conscious rats	12
the fact that	12
we demonstrated that	12
was performed to	12
multiple organ failure	12
area under the	12
and endothelial cells	12
severe lung injury	12
in human airway	12
as described above	12
increased expression of	12
thought to be	12
shown in figure	12
serum levels of	12
review of the	12
pulmonary edema and	12
lung injury model	12
and lung tissue	12
an in vitro	12
and found that	12
alveolar dead space	12
that of the	12
lung stem cells	12
is referred for	12
were significantly lower	12
the magnitude of	12
in the absence	12
injury in a	12
mediated transfer of	11
were used for	11
the differentially expressed	11
in both the	11
patients with covid	11
at zt and	11
in the human	11
it is not	11
a protective effect	11
suppressor of cytokine	11
levels of the	11
vitro and in	11
during the study	11
pulmonary microvascular endothelial	11
randomized controlled trial	11
activation of nf	11
repair and regeneration	11
the three groups	11
development of the	11
considered statistically significant	11
the analysis of	11
cytokines such as	11
of the present	11
significantly increased in	11
but not in	11
of ali induced	11
embedded in paraffin	11
epithelial cells in	11
induced by highly	11
endothelial barrier function	11
proliferated aec s	11
induction of ali	11
in the second	11
known to be	11
in vitro model	11
cardiogenic pulmonary edema	11
septic shock in	11
the proportion of	11
and hospital mortality	11
endothelial progenitor cells	11
and or outcome	11
the hypothesis that	11
plays a critical	11
is critical for	11
acts as a	11
institutes of health	11
are likely to	11
prospective cohort study	11
neutrophils in the	11
blood samples were	11
deposition in the	11
been implicated in	11
higher incidence of	11
was higher than	11
of the major	11
mrna and protein	11
was performed in	11
as a therapeutic	11
the united states	11
identified in the	11
the value of	11
of nitric oxide	11
differences between the	11
the survival rate	11
characterized by the	11
of inducible nitric	11
and severity of	11
a specifi c	11
for min and	11
tlr expression in	11
mechanism by which	11
the area of	11
determined by the	11
was to assess	11
was higher in	11
of p mapk	11
vascular permeability in	11
pulmonary edema in	11
of the total	11
was not associated	11
levels of ttp	11
transfer of the	11
admission to icu	11
intravenous administration of	11
inflammatory mediators and	11
suggesting that the	11
or septic shock	11
the neutrophil proteome	11
on examination she	11
medical and surgical	11
have not been	11
in this model	11
lps or clp	11
and duration of	11
of human airway	11
mean arterial pressure	11
stem cell therapy	11
not yet been	11
of multiple organ	11
lung inflammatory response	11
is caused by	11
highly pathogenic virus	11
the alveolar macrophages	11
in the group	11
could not be	11
inflammatory bowel disease	11
between the groups	11
to determine whether	11
in these patients	11
not significantly different	11
disruption of the	11
are shown in	11
patients with a	11
ttp myeko mice	10
and protein expression	10
we speculate that	10
lung injury is	10
nalp inflammasome assembly	10
was significantly increased	10
septic shock patients	10
of the genetic	10
some of the	10
mice were treated	10
cytokines in the	10
surfactant protein b	10
and characterization of	10
the involvement of	10
lung tissues of	10
a history of	10
injection of rtx	10
sepsis or septic	10
test was used	10
with the severity	10
repair of injured	10
did not differ	10
in the adult	10
study showed that	10
the final nebulisation	10
of ards and	10
in the usa	10
factors such as	10
w d ratio	10
and that the	10
to induce the	10
regulation of endothelial	10
is also a	10
room temperature for	10
genetic variations in	10
the s p	10
or acute respiratory	10
the effectiveness of	10
and results in	10
with higher mortality	10
in liquid nitrogen	10
the context of	10
how would you	10
in the literature	10
ali ards may	10
to be involved	10
activation of p	10
in rat lung	10
outcome of acute	10
indicating that the	10
that have been	10
she has a	10
also known as	10
the host response	10
were compared using	10
common cause of	10
into the lungs	10
progenitor cells in	10
into the alveolar	10
highly pathogenic viruses	10
derived from human	10
of the same	10
transforming growth factor	10
of injured lungs	10
for more than	10
protein expression of	10
of the protein	10
a patient with	10
b and c	10
risk factor for	10
that c a	10
higher levels of	10
effect on the	10
the alveolar dead	10
human bone marrow	10
followed by a	10
sachs et al	10
p mapk and	10
it may be	10
be an important	10
and at cells	10
was determined using	10
knockdown of hepcidin	10
pulmonary edema fluid	10
development of novel	10
the decision to	10
the potential of	10
animal care and	10
inflammatory cytokines in	10
the possibility of	10
a pivotal role	10
the lungs and	10
of inflammatory responses	10
to be the	10
during acute lung	10
by flow cytometry	10
expression of p	10
in rats with	10
li et al	10
may play a	10
phorbol myristate acetate	10
may contribute to	10
with increased mortality	10
was induced in	10
pulmonary drug delivery	10
therapeutic effect of	10
be due to	10
of patients in	10
was the most	10
effect of the	10
mechanisms of ali	10
was significantly lower	10
were collected from	10
as in the	10
infl uence of	10
h after operation	10
was used in	10
the injured lung	10
component of the	10
at least one	10
all patients admitted	10
were determined by	10
at risk of	10
and the severity	10
guidelines for the	10
human airway epithelia	10
on the first	10
mean age was	10
lung tissue and	10
have a higher	10
added to the	10
infl ammation and	10
to describe the	10
growth factor and	10
was found in	10
lung injury acute	10
to critical care	10
to test the	10
of nlrp inflammasome	10
been described in	10
production of proinflammatory	10
the recognition of	10
role of ttp	10
was measured using	10
have been associated	10
increased pulmonary vascular	10
a set of	10
and in vitro	10
ali ards and	10
mechanical ventilation for	10
injection of lps	10
in human lung	10
in lung epithelial	10
and is associated	10
increases in the	10
compared with other	10
to the severity	10
elevated in the	10
was added to	10
of mortality in	10
factor in the	10
human mesenchymal stem	10
to understand the	10
protein levels in	10
the g allele	10
such as sepsis	10
expressed as mean	10
no competing interests	10
to play a	10
the apache ii	10
variation in the	10
experiments were performed	10
key role in	10
associated with decreased	10
is a critical	10
lung tissues from	10
stay in icu	10
for use in	10
to validate the	10
as a consequence	10
followed by the	10
with the control	10
used as the	10
patients who died	10
angiotensin converting enzyme	10
ly g neutrophils	10
and epithelial cells	10
is a key	10
of oxidative stress	10
with a mean	10
central role in	10
as evidenced by	10
hepatic functional indexes	10
which may be	10
the phosphorylation of	10
associated with high	10
diseases such as	10
a randomized controlled	9
increase in pulmonary	9
polymorphism in the	9
in a model	9
for the first	9
use of melatonin	9
following the final	9
on mechanical ventilation	9
we investigated the	9
impact on the	9
by lps in	9
the apical side	9
function of the	9
ali rat model	9
in adult patients	9
lung compliance and	9
and may be	9
after induction of	9
large number of	9
such as il	9
presence of a	9
randomized controlled trials	9
may also be	9
to display the	9
the potential for	9
signal transduction pathway	9
expression of par	9
the work of	9
of curcumin on	9
organ failure in	9
of the control	9
variations in the	9
therapy for acute	9
were able to	9
rd day after	9
on admission to	9
calculated as the	9
or in the	9
the integrity of	9
were collected for	9
in alveolar epithelial	9
higher risk of	9
the respiratory tract	9
and endothelial cell	9
members of the	9
partial pressure of	9
lung injury via	9
significant difference between	9
inflammatory responses and	9
of p map	9
of patients had	9
a combination of	9
day mortality in	9
have no competing	9
levels were significantly	9
a is a	9
of these studies	9
pneumonia in wuhan	9
mediated by the	9
owing to the	9
be important in	9
has been demonstrated	9
mortality rate of	9
and animal models	9
patients suffering from	9
traf and traf	9
the infl uence	9
s p and	9
to the alveolar	9
the systemic circulation	9
relative levels of	9
a higher mortality	9
lead to the	9
and has been	9
genetic variation in	9
the first step	9
due to its	9
expression of tlr	9
has shown that	9
with the adult	9
half of the	9
apache ii scores	9
for cell entry	9
all patients with	9
with susceptibility to	9
it should be	9
levels of pro	9
is necessary to	9
wet dry weight	9
endothelial barrier dysfunction	9
in clinical trials	9
be used as	9
we assessed the	9
the early phase	9
to confirm the	9
and use of	9
into the lung	9
epidermal growth factor	9
was evaluated by	9
in patients at	9
significant reduction in	9
in the respiratory	9
and clinical studies	9
therapeutic target for	9
of granule content	9
to the activation	9
the emergency department	9
organ dysfunction in	9
lung and heart	9
and approved the	9
development of a	9
the characteristics of	9
in our icu	9
were measured by	9
alveolar macrophages were	9
compared with that	9
smoke for min	9
data were collected	9
recent studies have	9
associated with severe	9
needs to be	9
have been used	9
of laboratory animals	9
epa and dha	9
were the most	9
significantly reduced in	9
during the icu	9
with more than	9
patients treated with	9
of the tlr	9
in the united	9
lung tissue samples	9
vascular smooth muscle	9
were stained with	9
human airway epithelium	9
a subset of	9
higher in patients	9
c a antibody	9
its role in	9
number of studies	9
induced lung inflammation	9
were obtained at	9
at the same	9
h n infection	9
proteins involved in	9
cell signaling technology	9
and stored at	9
cd t cells	9
failure in the	9
linked to the	9
in the activation	9
with and without	9
ali caused by	9
inflammation and fibrosis	9
ec barrier enhancement	9
the human genome	9
ali ards in	9
integrity of the	9
in vivo studies	9
for the management	9
more than h	9
of critical care	9
use of laboratory	9
ali was induced	9
t cells and	9
we conducted a	9
which leads to	9
than those without	9
r d systems	9
group compared with	9
challenged wt mice	9
protein expression in	9
of par isoforms	9
as a novel	9
bronchial epithelial cells	9
study demonstrated that	9
c a and	9
we aimed to	9
development of ards	9
an increased risk	9
of endothelial barrier	9
were exposed to	9
were performed in	9
lung endothelial cell	9
at this time	9
the intensity of	9
severe sepsis or	9
number of ventilator	9
has been suggested	9
and use committee	9
the incidence and	9
the first time	9
epithelial cell cultures	9
in preclinical models	9
admitted in the	9
a group of	9
the prognosis of	9
extravascular lung water	9
of neutrophils and	9
cause of death	9
patients who developed	9
is made available	9
results in a	9
in trauma patients	9
gene transfer of	9
severity of illness	9
natural science foundation	9
and glutamyl transferase	9
important in the	9
group were significantly	9
the site of	9
in the normal	9
from the lung	9
is a rare	9
data not shown	9
from the blood	9
in human neutrophils	9
in the vascular	9
implicated in the	9
of tlr with	9
caused by the	9
of neutrophils to	9
therapeutic effects of	9
of neutrophils in	9
the care and	9
the epithelial cells	9
in severe sepsis	9
member of the	9
we found a	9
in the clp	9
the surface of	9
were detected in	9
of vascular permeability	9
experimental studies and	9
immune response in	9
several studies have	9
revealed that the	9
innate immune cells	9
in association with	9
as a negative	9
genes coding for	9
the balf of	9
were fixed in	9
then incubated with	9
compared to control	9
authors declare no	9
gene therapy for	9
total cell counts	9
the induction of	9
suggested that the	9
and western blot	9
the most frequent	9
been used to	9
nuclear factor kappa	9
hospital mortality was	9
mice were sacrificed	9
of alveolar epithelial	9
to obtain the	9
can be established	9
of these two	9
cell types in	9
of the nlrp	9
in the context	9
leads to a	9
the implementation of	9
used as an	9
fibrin deposition in	9
over a period	9
as described previously	9
relationship between the	9
expression in human	9
distress syndrome acute	9
was calculated as	9
in all patients	9
the reduction of	9
as assessed by	9
ali and sepsis	9
challenge with lps	9
major cause of	9
patients with chronic	9
the balance between	9
is based on	9
the first period	9
therapies for ali	9
used to identify	9
such as tnf	9
infiltration of neutrophils	9
the immune response	9
is an essential	9
sepsis and ali	9
the addition of	9
insertion deletion polymorphism	9
in children with	9
patients were studied	8
is thought to	8
to intensive care	8
not differ between	8
these changes were	8
and organ models	8
at the indicated	8
of novel coronavirus	8
the day of	8
and function of	8
results in increased	8
alveolar epithelial type	8
activation of caspase	8
in h n	8
we analyzed the	8
h time point	8
c a is	8
i r groups	8
induced by oleic	8
examination she has	8
by oleic acid	8
model was used	8
study suggests that	8
o f i	8
during mechanical ventilation	8
were resuspended in	8
in the mechanism	8
of red blood	8
a o f	8
lung wet dry	8
for each patient	8
the promoter region	8
it is also	8
a major role	8
have been successfully	8
group at each	8
in mice with	8
respiratory distress in	8
under a author	8
acute brain dysfunction	8
role of c	8
first days of	8
and sofa score	8
like receptor in	8
be attributed to	8
of cases of	8
a h n	8
their ability to	8
have not yet	8
attributed to the	8
of lung epithelial	8
rna was extracted	8
recruitment and activation	8
have focused on	8
a license to	8
pluripotent stem cell	8
mediated gene transfer	8
license to display	8
which is an	8
the preprint in	8
in ali patients	8
from mechanical ventilation	8
and can be	8
requiring mechanical ventilation	8
a author funder	8
level in the	8
of less than	8
effi cacy of	8
was found between	8
lower tidal volumes	8
the actin cytoskeleton	8
epithelial sodium channel	8
may be associated	8
ventilation with lower	8
was defined as	8
of human lung	8
clinical outcomes in	8
pulmonary inflammation and	8
as measured by	8
of the manuscript	8
mrna expression in	8
ii epithelial cells	8
been reported that	8
of a novel	8
the recruitment of	8
the repair of	8
not observed in	8
of neutrophil apoptosis	8
the acute phase	8
the blood of	8
a p value	8
respiratory failure is	8
a significant reduction	8
promoter region of	8
the airway epithelial	8
at baseline and	8
of lung tissue	8
on the day	8
the patients with	8
stay in the	8
of the lungs	8
identified as a	8
both proximal and	8
aec s in	8
of liver i	8
c a in	8
structure of the	8
to icu admission	8
p x receptor	8
the result of	8
was performed on	8
supported by the	8
of these proteins	8
of oleic acid	8
the overzealous host	8
of the pathophysiology	8
and c a	8
and management of	8
to acute respiratory	8
local and systemic	8
has granted medrxiv	8
models of acute	8
in combination with	8
cause of acute	8
the pulmonary circulation	8
have been made	8
mechanical ventilation was	8
who has granted	8
foundation of china	8
of ml kg	8
efficacy and safety	8
to quantify the	8
infiltration in the	8
the survival of	8
normalized to the	8
the development and	8
necrosis factor alpha	8
tlr inhibition group	8
the molecular mechanisms	8
outcomes in patients	8
any of the	8
than of the	8
the infiltration of	8
the lung and	8
of specifi c	8
posttraumatic stress disorder	8
in vitro studies	8
was no significant	8
low levels of	8
of the s	8
content and net	8
increased in the	8
granule content in	8
admitted to a	8
the upregulation of	8
sayed et al	8
significantly different between	8
granted medrxiv a	8
release of inflammatory	8
need for mechanical	8
those in the	8
used in this	8
with mortality in	8
aec s were	8
of immune cells	8
alveolar type i	8
data are presented	8
critical role of	8
role for the	8
we used a	8
injury acute respiratory	8
international license it	8
in the injured	8
were then incubated	8
is known to	8
fig s a	8
with an increased	8
f i o	8
induced increases in	8
and tlr trif	8
were analyzed using	8
mice were given	8
cells were washed	8
give rise to	8
hospital length of	8
to the same	8
pivotal role in	8
a potential therapeutic	8
was shown to	8
animal and organ	8
mice at zt	8
survivors of the	8
in a recent	8
of the host	8
examination reveals a	8
the membrane was	8
innate and adaptive	8
expressed genes in	8
of pulmonary vascular	8
the introduction of	8
total number of	8
stress disorder in	8
with sepsis and	8
was considered significant	8
prior to icu	8
a risk factor	8
more likely to	8
and clinical investigations	8
are the most	8
female is referred	8
the structure of	8
lung injury mice	8
the right lung	8
is consistent with	8
with ali and	8
the icu and	8
and vascular endothelial	8
been found to	8
lab work reveals	8
severity of disease	8
showed a significant	8
hypoxemic respiratory failure	8
organ dysfunction syndrome	8
science foundation of	8
activity in the	8
compared with control	8
lung tissue were	8
data were analyzed	8
regulated by the	8
a prospective observational	8
tissue from rats	8
sepsis and acute	8
bone marrow mscs	8
display the preprint	8
did not affect	8
protection against ali	8
used to evaluate	8
and regulation of	8
can lead to	8
bca protein assay	8
available under a	8
inflammatory cells and	8
model of sepsis	8
the patients who	8
acute myocardial infarction	8
of the endothelial	8
which is a	8
administration of a	8
the response to	8
that has been	8
the plasma membrane	8
ventilator associated pneumonia	8
at the onset	8
edema associated with	8
mice infected with	8
plasma concentration of	8
the milieu of	8
critically ill patient	8
gene expression profiling	8
f v t	8
challenged with lps	8
injury to the	8
at least in	8
in relation to	8
of tlr in	8
with regard to	8
should not be	8
are thought to	8
pathophysiology of sepsis	8
transfer to the	8
gene expression omnibus	8
the evolution of	8
medrxiv a license	8
tlr with myd	8
balf and serum	8
challenged wt and	8
injury and inflammation	8
lung vascular permeability	8
resulting in a	8
umbilical cord blood	8
inserted into the	8
the vascular endothelium	8
and regeneration of	8
tlr myd and	8
the infl ammatory	8
for disease modeling	8
induced increase in	8
this study is	8
seen in the	8
of nuclear factor	8
a cohort of	8
were anesthetized with	8
the ratio of	8
in inflammatory lung	8
indicates that the	8
type i cells	8
work was supported	8
who did not	8
organ failure and	8
to treat covid	8
the mean age	8
transient receptor potential	8
infected with sars	8
the gene expression	8
license it is	8
type ii epithelial	8
and it is	8
made available under	8
kras g d	8
in the patients	8
in the alveoli	8
genes in the	8
of the patient	8
due to their	8
in the hospital	8
a consequence of	8
tissues were harvested	8
protein assay kit	8
to the disease	8
significant difference in	8
the same time	8
was performed as	8
correlated with the	8
in vitro expansion	8
myd and tlr	8
hospital mortality rate	8
into three groups	8
the alveolar spaces	8
has been implicated	8
hepcidin knockdown mice	8
more than of	8
the protective effect	8
of reactive oxygen	8
the myosin light	8
p a o	8
should be considered	8
the resolution of	8
in lung and	8
impact of the	8
the therapeutic effect	8
the acute lung	8
than those of	8
the first day	8
traumatic stress disorder	8
diurnal changes in	8
the prevalence of	8
present study was	8
exposed to smoke	8
the critically ill	8
cancer stem cells	8
the th day	8
the sections were	8
inflammatory cells in	8
the contribution of	8
with renal failure	8
the repair and	8
u day group	8
with hematoxylin and	8
surviving sepsis campaign	8
low tidal volume	8
and angiotensin ii	8
of studies have	8
may be an	8
the late phase	8
mortality in ards	8
were used in	8
in a significant	8
ards may be	8
doses of hydrocortisone	8
in the other	8
appear to be	8
studies demonstrated that	8
role of p	8
released from the	8
preprint in perpetuity	8
oleic acid injection	8
it is made	8
cells in vitro	8
to be important	8
neutrophil apoptosis in	8
in the medical	8
with susceptibility and	8
by western blot	8
read and approved	8
of endothelial cells	8
study indicates that	8
and apache ii	8
interstitial lung disease	8
was no statistical	8
used to treat	8
lung injury score	8
of at cells	8
were admitted in	8
the kinetics of	8
the progression of	7
in the rat	7
of hospital stay	7
g for min	7
related quality of	7
it is a	7
to analyze the	7
and critical care	7
are shown as	7
reduction of the	7
sections were then	7
effect of curcumin	7
in endothelial cells	7
lung injury or	7
that the downregulation	7
immune response to	7
we showed that	7
higher mortality and	7
cells in a	7
patients had a	7
cohort of patients	7
for this preprint	7
absence of a	7
in a single	7
resulting in the	7
in the clinical	7
in the repair	7
pi k akt	7
of our study	7
at high risk	7
was not significantly	7
mouse monoclonal antibody	7
mice compared to	7
leading cause of	7
sodium transport and	7
and the alveolar	7
are normalized to	7
apoptosis in the	7
of organoids in	7
plays a role	7
yang et al	7
after lps or	7
membranes were incubated	7
upregulated in the	7
patients with diabetes	7
parts of the	7
the late endosome	7
important roles in	7
and lung tissues	7
it is difficult	7
the airway epithelium	7
in the levels	7
has been developed	7
cell colony enhancing	7
icu or hospital	7
mediators in the	7
and outcome from	7
in the blood	7
national institute of	7
statistical analyses were	7
injury by inhibiting	7
old female with	7
severity of ards	7
prior to the	7
along with the	7
alveolar septal thickening	7
after cardiac surgery	7
our study was	7
well as a	7
tlr signaling pathway	7
in the promoter	7
development and disease	7
of blood products	7
on examination he	7
alveolar macrophages and	7
have been identified	7
total rna was	7
of the circuit	7
sato et al	7
in vascular permeability	7
it is unlikely	7
animal model of	7
and development of	7
a and c	7
and canine models	7
higher mortality rate	7
may have been	7
over a month	7
the apical surface	7
aec s was	7
to enhance the	7
the supernatant was	7
importance of the	7
levels of pai	7
by the presence	7
human intestinal organoids	7
and incubated at	7
risk factors of	7
be related to	7
length of hospital	7
has long been	7
in the last	7
high risk of	7
effects of msc	7
in the patient	7
of lung inflammation	7
of the three	7
inflammation and injury	7
the disease of	7
higher than in	7
uence of genetic	7
was based on	7
reperfusion injury in	7
traditional tidal volumes	7
with lps and	7
of the airway	7
were identified by	7
nitric oxide and	7
old female is	7
lactate requests in	7
major causes of	7
for multiple comparisons	7
intestinal stem cells	7
lung injury a	7
of all patients	7
pulmonary expression of	7
age of years	7
may be due	7
were identified in	7
failure due to	7
essential for the	7
of the lps	7
was extracted from	7
on the nd	7
fluid of patients	7
transmembrane conductance regulator	7
in this chapter	7
were measured with	7
and are associated	7
of stem cells	7
in comparison with	7
area of the	7
lung tissue in	7
the existence of	7
on the outcome	7
in the neutrophil	7
for the care	7
survival of patients	7
those of the	7
proteins in the	7
are characterized by	7
are consistent with	7
of the genome	7
differentiated human airway	7
induced ali was	7
of alveolar edema	7
in alveolar spaces	7
may infl uence	7
h o and	7
pathophysiology of ali	7
were performed by	7
treatment of the	7
in human pulmonary	7
glutamyl transferase were	7
in airway epithelial	7
under the roc	7
a protective role	7
promise in preclinical	7
prevention and treatment	7
the alveolar epithelial	7
that patients with	7
knowledge of the	7
icu stay and	7
the extracellular matrix	7
the overexpression of	7
a series of	7
but there was	7
we studied patients	7
huang et al	7
be a promising	7
of stay and	7
predictive value of	7
between patients with	7
reported in the	7
for evaluation of	7
is dependent on	7
the activities of	7
this work was	7
these findings suggest	7
is referred to	7
a large number	7
in a time	7
numbers of neutrophils	7
v t ratio	7
innate immune system	7
of dubs in	7
had a higher	7
per time point	7
in the corresponding	7
effect of s	7
bronchioalveolar stem cells	7
in supplementary table	7
the early stage	7
the generation of	7
lung epithelial and	7
and clinical trial	7
zfp flox flox	7
is needed to	7
committee of the	7
the ali and	7
v group at	7
critical care medicine	7
be a potential	7
mortality rates were	7
with increased levels	7
in the late	7
a pao fio	7
overexpression of the	7
one of these	7
the endothelial barrier	7
of the cytokine	7
of organ dysfunction	7
infection in mice	7
tidal volumes as	7
levels of proinflammatory	7
models of lung	7
study was supported	7
significantly elevated in	7
chain kinase gene	7
adaptive immune responses	7
p f ratio	7
ec barrier function	7
correlation between the	7
patients who underwent	7
serum and lung	7
none of the	7
severe sepsis in	7
cortical actin ring	7
and did not	7
randomly divided into	7
number of patients	7
was applied to	7
of these cells	7
according to a	7
as one of	7
of protein c	7
of icu admission	7
significantly decreased in	7
the mortality in	7
of patients who	7
blood gas analysis	7
with novel coronavirus	7
mice treated with	7
and lung inflammation	7
stress doses of	7
were randomly divided	7
production of tnf	7
in which the	7
recent advances in	7
the lung in	7
short hairpin rna	7
lgr stem cells	7
intratracheal instillation of	7
in pulmonary vascular	7
hepcidin in aecs	7
of more than	7
into two groups	7
and safety of	7
with acute exacerbation	7
findings suggest that	7
lobe of the	7
during icu stay	7
to smoke for	7
these results indicate	7
compared with traditional	7
copyright holder for	7
act as a	7
from the bone	7
lungs of the	7
of hyaline membranes	7
of the experiment	7
in the oleic	7
nitration at y	7
gene expression and	7
were collected and	7
of proinflammatory mediators	7
based lipid emulsions	7
onset of ards	7
pathophysiology of acute	7
we evaluated the	7
risk for ards	7
effects in the	7
treatment of ards	7
protein in the	7
it is likely	7
are expressed in	7
genes related to	7
was performed with	7
myd or trif	7
investigated the effects	7
the cytokine storm	7
at the level	7
the area under	7
is known about	7
depend on the	7
to determine if	7
by the national	7
the underlying mechanisms	7
of expression of	7
the respiratory system	7
samples were collected	7
is composed of	7
with a higher	7
human pluripotent stem	7
intensive care patients	7
tyrosine phosphorylation of	7
concentration in the	7
in a large	7
acute and chronic	7
the arterial blood	7
on the surface	7
were not significantly	7
canine models of	7
is a novel	7
effects of melatonin	7
influenza a h	7
this may be	7
cells derived from	7
in this review	7
inflammation in acute	7
b and il	7
accumulation in the	7
in gas exchange	7
is believed to	7
to be used	7
in case of	7
the surfactant protein	7
types in the	7
vitro model of	7
and goblet cells	7
stem cell niche	7
approved the final	7
shown as mean	7
been successfully used	7
colony enhancing factor	7
a phase ii	7
were no differences	7
association studies have	7
partial thromboplastin time	7
we also found	7
increased mortality in	7
shown to reduce	7
differential regulation of	7
may have a	7
pathogenesis of ards	7
phosphatase and glutamyl	7
to the study	7
to reduce mortality	7
was considered statistically	7
higher expression of	7
at admission and	7
is necessary for	7
the stem progenitor	7
mice were randomly	7
holder for this	7
genes involved in	7
is a negative	7
inflammatory and anti	7
the limitations of	7
lead to a	7
in the previous	7
data are shown	7
ali in the	7
inflammation and apoptosis	7
associated with mortality	7
surface or early	7
within the lung	7
function of alveolar	7
in patients admitted	7
seems to be	7
may be the	7
polyunsaturated fatty acids	7
carriers of the	7
outcome in acute	7
lung epithelial cell	7
of the neutrophil	7
evaluate the effect	7
study in a	7
major role in	7
ards patients with	7
contribution to the	7
may not be	7
the copyright holder	7
the response of	7
effect of palm	7
as mentioned above	7
volumes as compared	7
was lower than	7
in the bronchoalveolar	7
the synthesis of	7
significantly associated with	7
the clp and	7
each of the	7
that occur in	7
were approved by	7
of mesenchymal stem	7
it is necessary	7
a prospective cohort	7
wt and ttp	7
volumes for acute	7
regulator of the	7
with traditional tidal	7
ali is a	7
the ali model	7
isolated from the	7
with that in	7
human umbilical cord	7
community acquired pneumonia	7
it is possible	7
gene expression of	7
effect of sars	7
phase of ards	7
is the major	7
and net formation	7
outcome in ards	7
inhibition of nlrp	7
via the late	7
we have also	7
of peripheral blood	7
with myd or	7
focused on the	7
three times with	7
as part of	7
of the studies	7
alkaline phosphatase and	7
inflammatory response syndrome	7
the differential diagnosis	7
were expressed as	7
inflammation and the	7
of an enteral	7
braf v e	7
has been described	7
susceptibility and severity	7
by influenza a	7
h at room	7
the type of	7
mechanisms of the	7
serum amyloid a	7
the change in	7
serve as a	7
hospitalized patients with	7
on the cell	7
acute inflammatory lung	7
or early endosome	7
onset severe sepsis	7
declare no conflict	7
the immune system	7
the rats were	7
inflammatory mediators in	7
the total number	7
international cohort study	7
infection and inflammation	7
ali has not	7
of inspired oxygen	7
decreased in the	7
inflammatory cell infiltration	7
which was not	7
ards in the	7
cells and their	7
the host immune	7
first h of	7
icu of a	7
required mechanical ventilation	7
were detected by	7
to investigate whether	7
side of the	7
result in the	7
to the pulmonary	7
polymorphism is associated	7
temperature for h	7
were taken at	7
is critical to	7
signal transduction pathways	7
but it is	7
was to investigate	7
located in the	7
we used the	7
surface area of	7
stained with hematoxylin	7
novel coronavirus in	7
be induced by	7
and alveolar macrophages	7
tidal volumes for	7
of the pulmonary	7
icu mortality was	7
interaction of tlr	7
in the process	7
zhang and colleagues	7
pandemic influenza a	7
present in the	7
mesenchymal stromal cells	7
not related to	7
tumour necrosis factor	7
c a receptor	7
comorbid medical conditions	7
made in the	7
of genetic variations	7
higher than the	7
gas exchange and	7
an attractive target	7
characteristics of the	7
two groups were	7
with lower tidal	7
alveolar epithelial barrier	7
was lower in	7
lung infl ammation	7
oxygen partial pressure	7
and neutrophil infiltration	7
activity of the	7
in mice and	7
but there is	7
was not peer	7
more susceptible to	7
on the contrary	7
polymorphisms have been	7
attenuates acute lung	7
been suggested that	7
lps and ifn	7
management of severe	7
may be involved	7
ii score was	7
ischemia reperfusion injury	7
mean apache ii	7
hou et al	7
and sofa scores	7
contributes to the	7
all of the	7
adult stem cells	7
the final manuscript	7
of the anti	7
outcome of patients	7
lung injury through	7
of gossypol on	7
inflammatory response by	7
the beginning of	7
involvement of the	7
analyzed using the	6
mpo activity in	6
factor in acute	6
play important roles	6
analysis of these	6
tissue plasminogen activator	6
clinical trials have	6
in the liver	6
studies suggest that	6
by inhibiting the	6
safety and efficacy	6