bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
lung injury	1046
acute lung	653
acute respiratory	464
respiratory distress	366
distress syndrome	346
ali ards	313
mechanical ventilation	242
stem cells	224
epithelial cells	202
intensive care	189
induced ali	183
septic shock	168
lung tissue	159
respiratory failure	155
induced lung	145
critically ill	130
growth factor	126
severe sepsis	126
inflammatory response	123
gene expression	122
induced acute	112
control group	109
lung tissues	107
mg kg	106
pulmonary edema	104
endothelial cells	101
lung inflammation	98
vascular permeability	95
mesenchymal stem	93
stem cell	91
endothelial cell	89
apache ii	88
bone marrow	87
care unit	87
ill patients	87
inflammatory cytokines	87
like receptor	85
alveolar epithelial	83
alveolar macrophages	83
progenitor cells	80
animal models	80
vascular endothelial	73
oleic acid	71
critical care	71
airway epithelial	70
necrosis factor	70
liver i	70
ards patients	66
nitric oxide	65
tumor necrosis	64
human lung	64
bronchoalveolar lavage	63
hospital mortality	62
patients admitted	62
ttp ko	61
immune response	60
respiratory syndrome	59
protein kinase	59
challenged ttp	59
severe acute	58
mortality rate	57
present study	57
risk factors	57
stem progenitor	57
significantly higher	55
activated protein	54
organ dysfunction	54
inflammatory mediators	54
type ii	54
mechanically ventilated	54
association studies	53
innate immune	53
converting enzyme	53
cell types	53
epithelial cell	53
clinical trials	52
organ failure	52
endothelial barrier	52
icu stay	51
inflammatory responses	51
endothelial growth	51
mouse model	51
two groups	51
lung epithelial	50
nlrp inflammasome	50
ng ml	50
lps administration	50
day mortality	49
cord uid	48
proinflammatory cytokines	48
doc id	48
icu admission	47
ventilated patients	47
human airway	46
signaling pathways	45
significant differences	45
oxidative stress	45
important role	45
ml kg	44
tlr signaling	44
barrier function	44
immune responses	43
mortality rates	43
pulmonary vascular	43
ii score	43
immune cells	42
significantly reduced	42
tidal volume	41
lps challenge	41
renal failure	41
multiple organ	41
time point	40
alveolar epithelium	40
gas exchange	39
derived organoids	39
nuclear factor	39
blood pressure	39
type i	39
performed using	38
rat model	38
granule content	38
differentially expressed	38
pao fio	38
septic patients	38
smoke inhalation	38
lavage fluid	37
significantly increased	37
statistical analysis	37
icu mortality	36
bal fluid	36
protein expression	36
signal transduction	36
infl uence	36
inflammatory cells	36
fluid clearance	36
signaling pathway	36
barrier dysfunction	35
pulmonary fibrosis	35
lung disease	35
clinical trial	35
statistically significant	35
extended data	35
injury induced	35
infl ammatory	35
cystic fibrosis	34
inflammatory lung	34
arterial blood	34
protein levels	34
lps group	34
protective effect	34
gene therapy	34
inflammatory cytokine	34
higher mortality	34
syndrome coronavirus	33
organoids derived	33
ec barrier	33
nebulised heparin	33
western blot	33
ko mice	33
virus infection	33
airway epithelium	33
protective effects	33
gene transfer	33
reperfusion injury	33
influenza virus	33
mean age	33
rat lung	32
previous studies	32
adult respiratory	31
cardiac surgery	31
cohort study	31
immune system	31
nalp inflammasome	31
lung diseases	31
lung cancer	30
oxide synthase	30
critical role	30
may also	30
significant difference	30
cytokine storm	30
derived evs	30
adult patients	30
angiotensin ii	30
genetic variations	30
alveolar type	30
alveolar fluid	29
previously described	29
barrier enhancement	29
barrier integrity	29
novel coronavirus	29
cell death	29
dendritic cells	29
body weight	29
significantly lower	29
intestinal organoids	29
pluripotent stem	29
smooth muscle	29
murine model	29
alveolar space	29
pulmonary inflammation	29
highly pathogenic	29
time points	29
logistic regression	28
reactive oxygen	28
ali model	28
sodium transport	28
room temperature	28
cytokine production	28
data suggest	28
ttp myeko	28
lung organoids	27
clinical studies	27
ischemia reperfusion	27
expressed genes	27
observational study	27
three groups	27
controlled trial	27
infl ammation	27
respiratory tract	27
heart failure	27
innate immunity	27
challenged wt	27
thermo fisher	27
light chain	26
icu patients	26
genetic polymorphisms	26
treated mice	26
lung endothelial	26
hemorrhagic shock	26
cells via	26
care units	26
systemic inflammation	26
blood samples	26
binding protein	26
lung vascular	26
noninfluenza group	26
cell barrier	25
cell signaling	25
high mortality	25
myosin light	25
results showed	25
inflammasome activation	25
dry weight	25
blood gas	25
recent studies	25
therapeutic potential	25
transcription factor	25
pulmonary hypertension	25
plasminogen activator	25
authors declare	25
negative regulator	25
control mice	25
molecular mechanisms	25
analysis showed	25
myocardial infarction	24
trauma patients	24
proinflammatory cytokine	24
systematic review	24
fish oil	24
alveolar damage	24
cell proliferation	24
edema fluid	24
survival rate	24
viral infection	24
united states	24
growth factors	24
cell apoptosis	24
adhesion molecule	24
systemic inflammatory	24
epithelial barrier	23
lung inflammatory	23
induced inflammation	23
increased mortality	23
inflammatory diseases	23
results suggest	23
stimulating factor	23
commonly used	23
amino acid	23
critical illness	23
oxygen species	23
fatty acids	23
injured lung	23
progenitor cell	23
likely diagnosis	23
stromal cells	23
cell lines	23
coronavirus disease	23
airway epithelia	23
heart rate	23
mpo activity	23
pulmonary disease	23
pulmonary microvascular	23
increased levels	22
ex vivo	22
map kinase	22
clinical characteristics	22
derived stem	22
macrophage migration	22
injured lungs	22
host response	22
chain kinase	22
inhibitory factor	22
blood cells	22
increased risk	22
knockout mice	22
like receptors	22
induced pulmonary	22
widely used	22
peripheral blood	22
cardiac output	22
tipe overexpression	22
candidate gene	22
ali models	22
ii cells	22
free days	22
lps stimulation	22
chronic obstructive	22
hepatocyte growth	22
human neutrophils	21
expression levels	21
neutrophil infiltration	21
cell surface	21
tidal volumes	21
clinical isolates	21
cytokine signaling	21
obstructive pulmonary	21
genetic association	21
randomized controlled	21
keratinocyte growth	21
ali induced	21
candidate genes	21
saps ii	21
lung function	21
based therapies	21
surfactant protein	20
blot analysis	20
acquired pneumonia	20
wet dry	20
tumor organoids	20
lung stem	20
wt mice	20
high levels	20
three times	20
old female	20
significant increase	20
way anova	20
arterial pressure	20
fi brosis	20
neutrophil elastase	20
self assessment	20
alveolar spaces	20
significantly decreased	20
rac nitration	20
replacement therapy	20
gene coding	20
bacterial infection	20
lung damage	20
migration inhibitory	20
injury model	20
respiratory diseases	20
ali susceptibility	20
ali mice	19
significantly different	19
umbilical cord	19
barrier regulation	19
determined using	19
increased significantly	19
drug screening	19
plasma levels	19
cardiac index	19
cell cycle	19
net formation	19
western blotting	19
predictive value	19
cell counts	19
several studies	19
sofa score	19
inducible nitric	19
extracellular matrix	19
hospital stay	19
respiratory rate	19
tlr expression	19
escherichia coli	19
mouse lung	19
total protein	19
cardiac function	19
red blood	19
lung compliance	19
current study	19
signalling pathway	19
tissue damage	19
palm expression	19
muscle cells	19
risk factor	18
study period	18
cell membrane	18
associated pneumonia	18
kidney injury	18
host immune	18
enhancing factor	18
monoclonal antibody	18
type mice	18
transcription factors	18
supplementary table	18
patients receiving	18
rat lungs	18
endothelial permeability	18
smoke exposure	18
recombinant human	18
negative bacteria	18
dependent manner	18
capillary barrier	18
pandemic influenza	18
human pulmonary	18
receptor signaling	18
blood flow	18
emergency department	18
mrna expression	18
increased vascular	18
ali cultures	18
regression analysis	18
lung water	18
may play	18
alveolar edema	18
cytokine release	18
breast cancer	18
microvascular endothelial	18
derived exosomes	18
cell entry	17
flow cytometry	17
severe lung	17
human coronavirus	17
basal cells	17
cell culture	17
dead space	17
polymicrobial sepsis	17
rd day	17
stress disorder	17
proinflammatory mediators	17
measured using	17
cecal ligation	17
avian influenza	17
injury date	17
blood vessels	17
weight ratio	17
pressure support	17
acute kidney	17
host defense	17
associated virus	17
ml min	17
considered significant	17
evidence suggests	17
acute renal	17
inflammatory cell	17
therapeutic target	17
therapeutic effects	17
neutrophil apoptosis	17
among covid	17
animal studies	17
cortical actin	17
patients infected	17
drug delivery	17
vascular barrier	17
assessment questions	17
cell therapy	17
barrier disruption	16
elevated levels	16
lung edema	16
pulmonary oedema	16
challenged mice	16
cell line	16
neutrophil recruitment	16
intercellular adhesion	16
animal model	16
prospective study	16
prospective observational	16
medical conditions	16
vascular endothelium	16
pathological changes	16
cytoskeletal rearrangement	16
health care	16
preclinical models	16
study showed	16
partial pressure	16
genetic variation	16
infected mice	16
airway organoids	16
adaptive immune	16
experimental studies	16
mlc phosphorylation	16
high risk	16
organoid culture	16
inflammatory effects	16
syncytial virus	16
metabolic pathways	16
therapeutic targets	16
acute pancreatitis	16
personalized medicine	16
novel therapeutic	16
space fraction	16
splen group	16
fio ratio	15
disease modeling	15
patients received	15
potential therapeutic	15
negatively regulates	15
viral infections	15
total rna	15
phase iii	15
actin cytoskeleton	15
two patients	15
retrospective study	15
human genome	15
bl mice	15
ali group	15
total cell	15
stellate ganglia	15
injury caused	15
pg ml	15
acid group	15
neutrophil extracellular	15
par isoforms	15
extracellular traps	15
airway pressure	15
yousaf ali	15
mechanical stress	15
pulmonary artery	15
smartcare ps	15
recent study	15
lung pathology	15
associated lung	15
tumor cells	15
idiopathic pulmonary	15
respiratory syncytial	15
microvascular permeability	15
ali culture	15
ards may	15
university hospital	15
expression profiling	15
protein concentration	15
pulmonary injury	15
previous study	15
activator inhibitor	15
clinical features	15
acute myocardial	15
cystic fi	15
oxygen delivery	15
therapeutic effect	15
vascular leak	15
hospital discharge	15
pulmonary diseases	15
results indicate	15
amino acids	15
recent years	15
inhalation therapy	15
blood products	15
clinical outcomes	15
analyzed using	15
median age	14
extracorporeal membrane	14
humana press	14
injury via	14
serum levels	14
ec permeability	14
pathways involved	14
like neutrophils	14
early phase	14
acute exacerbation	14
treated rats	14
statistical significance	14
group received	14
human studies	14
science business	14
surgical icu	14
icu length	14
reduced lung	14
east respiratory	14
effi ciency	14
linked immunosorbent	14
severe form	14
therapeutic strategy	14
surface area	14
acute inflammatory	14
another study	14
patients undergoing	14
group box	14
springer science	14
remains unclear	14
promoter region	14
intracranial hypertension	14
membrane oxygenation	14
one patient	14
flox control	14
compared using	14
lung organoid	14
mean arterial	14
fisher scientific	14
pulmonary arterial	14
similar results	14
mobility group	14
lung models	14
also found	14
examination reveals	14
mg dl	14
organ injury	14
influenza infection	14
pulmonary endothelium	14
higher risk	14
cell colony	14
tissue injury	14
conscious rats	14
invasive mechanical	14
middle east	14
oxidized phospholipids	14
mg ml	14
evans blue	14
ms ms	14
business media	14
inflammatory bowel	14
cell type	14
proximal airway	14
immunosorbent assay	14
liquid interface	14
protein level	14
diffuse alveolar	14
adhesion molecules	14
lps ifn	14
cell migration	14
buffered saline	13
rac gtpase	13
pufa ratio	13
transepithelial sodium	13
differential expression	13
national institutes	13
animal care	13
intratracheal administration	13
consecutive patients	13
central role	13
derived mesenchymal	13
lipid emulsions	13
deficient mice	13
alveolar macrophage	13
significantly inhibited	13
mediated gene	13
cleaved caspase	13
pivotal role	13
first days	13
mice compared	13
neutrophil accumulation	13
tyrosine phosphorylation	13
invasive ventilation	13
effi cacy	13
per group	13
tissue factor	13
neutrophil proteome	13
lysis buffer	13
respiratory infections	13
goblet cells	13
associated ali	13
lung cells	13
cell cultures	13
stress fibers	13
group compared	13
induced pluripotent	13
pct levels	13
assay kit	13
significantly elevated	13
normal lung	13
based approaches	13
lg ml	13
clinical data	13
sofa scores	13
rights reserved	13
taken together	13
type diabetes	13
pseudomonas aeruginosa	13
ali patients	13
cell infiltration	13
cytokine levels	13
time pcr	13
colorectal cancer	13
infectious diseases	13
increased expression	13
culture system	13
myocardial injury	12
barrier permeability	12
may lead	12
inflammatory effect	12
proliferated aec	12
shrna group	12
key role	12
cellular infiltration	12
lab work	12
may contribute	12
posttraumatic stress	12
gastric cancer	12
prospective cohort	12
adipose tissue	12
lung weight	12
demographic data	12
tissue samples	12
within days	12
icu admissions	12
mouse lungs	12
higher incidence	12
alkaline phosphatase	12
increased pulmonary	12
surviving sepsis	12
ammatory response	12
santa cruz	12
vascular leakage	12
inflammasome assembly	12
th day	12
kg min	12
care medicine	12
nadph oxidase	12
exogenous surfactant	12
made available	12
antibiotic therapy	12
deubiquitinating enzymes	12
fibrin deposition	12
years old	12
tissue repair	12
endothelial progenitor	12
drug discovery	12
intravenous administration	12
polymerase chain	12
deubiquitinating enzyme	12
inflammatory properties	12
mediated transfer	12
cardiopulmonary bypass	12
percutaneous tracheostomy	12
induced sepsis	12
renal replacement	12
acute physiology	12
shock patients	12
higher levels	12
intraperitoneal injection	12
beneficial effects	12
injured patients	12
lung ischemia	12
diabetes mellitus	12
alveolar dead	12
viral vectors	12
among patients	12
drug development	12
described previously	12
month period	12
tlr gene	12
inspired oxygen	12
clara cells	12
oxygen saturation	12
cell count	12
study demonstrated	12
also confirmed	12
plasma membrane	12
arachidonic acid	12
pulmonary pathology	12
immunohistochemical staining	12
whole blood	12
chain reaction	12
secondary antibody	12
alveolar pneumocytes	12
first step	12
genetic variants	12
head injury	12
hyaline membranes	12
renal function	12
gastric contents	12
organoid cultures	12
considered statistically	11
gene transcription	11
central venous	11
cas technology	11
lung parenchyma	11
controlled trials	11
derived hepcidin	11
ethics committee	11
primary human	11
systemic circulation	11
epithelial type	11
response syndrome	11
death risk	11
cell membranes	11
also known	11
died within	11
clinical course	11
fluid transport	11
vitro model	11
induced inflammatory	11
inflammatory markers	11
cigarette smoke	11
pct level	11
mouse monoclonal	11
ali candidate	11
determine whether	11
reduce mortality	11
glutamyl transferase	11
acute pulmonary	11
early stage	11
protein assay	11
injury score	11
receptor antagonist	11
rac protein	11
using crispr	11
study group	11
electron microscopy	11
club cells	11
human bronchial	11
time course	11
cardiogenic pulmonary	11
coronary artery	11
competing interests	11
studies demonstrated	11
complement activation	11
rabbit anti	11
high doses	11
myristate acetate	11
clinical practice	11
infectious disease	11
bronchial epithelial	11
carbon dioxide	11
cell adhesion	11
disease process	11
bowel disease	11
also showed	11
pulmonary drug	11
tir domain	11
free radicals	11
pulmonary endothelial	11
organ models	11
mm tris	11
adult stem	11
activated receptor	11
inflammatory injury	11
pathogenic virus	11
heat shock	11
uric acid	11
human mesenchymal	11
deletion polymorphism	11
gap formation	11
myeloid cells	11
protective role	11
positive control	11
dna damage	11
mesenchymal stromal	11
acid aspiration	11
phase ii	11
spontaneous breathing	11
gene delivery	11
liver injury	11
day survival	10
rac activation	10
angiotensin converting	10
left ventricular	10
interstitial edema	10
important roles	10
patients without	10
cancer stem	10
first period	10
distal lung	10
enteral nutrition	10
clinical study	10
major role	10
gene variants	10
host cells	10
bacterial infections	10
intratracheal instillation	10
right lung	10
cancer cells	10
induced protein	10
pathogenic viruses	10
ventilator associated	10
significantly attenuated	10
vivo studies	10
expiratory pressure	10
major trauma	10
extracellular vesicles	10
dependent pathway	10
sepsis bundles	10
mrna levels	10
supportive care	10
distal airway	10
lower tidal	10
active ingredients	10
sham operation	10
human bone	10
granule proteins	10
tlr myd	10
meningococcal disease	10
normal rats	10
blood cultures	10
intestinal stem	10
spinal afferents	10
infected patients	10
cancer organoids	10
genes involved	10
virus replication	10
pulmonary stem	10
ali rat	10
infected hae	10
cardiovascular disease	10
human disease	10
adverse effects	10
respiratory disease	10
least one	10
neutrophil activation	10
days mortality	10
final nebulisation	10
significant reduction	10
organoid lines	10
scoring system	10
negative control	10
insertion deletion	10
linolenic acid	10
sodium channel	10
alveolar cells	10
cerebral organoids	10
ast treatment	10
lung endothelium	10
organ dysfunctions	10
impaired afc	10
severe pneumonia	10
lung cell	10
lung regeneration	10
patients developed	10
late phase	10
new onset	10
pathway analysis	10
tlr mrna	10
cardiac arrest	10
molecular weight	10
severe hypoxemia	10
mouse anti	10
distal alveolar	10
control animals	10
basement membrane	10
lung wet	10
tyrosine kinase	10
adenoviral vector	10
hepcidin knockdown	10
pulmonary function	10
alveolar wall	10
severe respiratory	10
significant protection	10
functional indexes	10
multivariate analysis	10
community acquired	10
patients treated	10
intracellular iron	10
lung fluid	10
transforming growth	10
pulmonary epithelial	10
laboratory animals	10
even though	10
myeko mice	10
antiviral responses	10
ventilatory support	10
serum hmgb	10
per day	10
soybean oil	10
enteroendocrine cells	10
patients suffering	10
identifi ed	10
improved survival	10
ttp expression	10
adult lung	10
common cause	10
human intestinal	10
cell suspension	10
hepatic functional	10
square test	10
including ali	10
liquid nitrogen	10
injury acute	10
old male	10
phorbol myristate	10
care patients	10
fluid balance	10
many studies	10
therapeutic interventions	10
solid bar	10
clinically relevant	10
septic mice	10
pulmonary circulation	10
septal thickening	10
rna seq	10
influenza viruses	9
secondary antibodies	9
mm nacl	9
surgical patients	9
regression model	9
syndrome acute	9
previous reports	9
healthy volunteers	9
coa reductase	9
coronavirus infection	9
traditional tidal	9
acute inflammation	9
polyclonal antibody	9
ii scores	9
human alveolar	9
hospital charges	9
day post	9
ciliated cells	9
sars coronavirus	9
nitrate nitrite	9
factor kappa	9
cell populations	9
science foundation	9
culture media	9
underlying mechanisms	9
inflammatory process	9
gram negative	9
higher doses	9
rho kinase	9
ace inhibitors	9
liver ischemia	9
epithelial sodium	9
obese patients	9
arterial oxygen	9
oxygenation index	9
medical patients	9
reactive protein	9
gtpase activity	9
significant correlation	9
relative levels	9
traumatic brain	9
national institute	9
first time	9
trauma system	9
signaling technology	9
extravascular lung	9
medical icu	9
side effects	9
deficient neutrophils	9
blood gases	9
inflammatory disorders	9
expression level	9
attenuates acute	9
mm hg	9
mean apache	9
human umbilical	9
per time	9
lung microvascular	9
catalytic domain	9
differential regulation	9
myeloid cell	9
mice treated	9
rheumatoid arthritis	9
studied patients	9
recent advances	9
cell shape	9
mediated ali	9
therapeutic strategies	9
improves survival	9
grant acknowledgement	9
primary antibodies	9
transduction pathways	9
lung alveolar	9
derived mvs	9
days post	9
chemokine receptors	9
adverse events	9
ascitic fluid	9
protease inhibitor	9
apical side	9
multiple comparisons	9
epithelial damage	9
increased lung	9
use committee	9
epithelial organoids	9
fatty acid	9
four members	9
ali caused	9
cold pbs	9
lung development	9
activated receptors	9
flox flox	9
binding lectin	9
essential role	9
gene polymorphisms	9
horseradish peroxidase	9
hairpin rna	9
developed ards	9
angiotensin system	9
culture conditions	9
standard deviation	9
positive end	9
six patients	9
single nucleotide	9
lgr stem	9
alveolar walls	9
genes coding	9
teaching hospital	9
cardiogenic shock	9
tyrosine nitration	9
controlled clinical	9
light microscope	9
respiratory system	9
positive association	9
transduction pathway	9
hypoxemic respiratory	9
factor gene	9
increased permeability	9
large number	9
roc curve	9
san diego	9
lung index	9
overzealous host	9
induced increase	9
airway inflammation	9
biological processes	9
predicted mortality	9
surface expression	9
mv duration	9
plasma extravasation	9
proteins involved	9
major cause	9
phosphate receptor	9
transient receptor	9
sized blood	9
severely ill	9
cell function	9
vascular smooth	9
terminal kinase	9
isolated rat	9
epidermal growth	9
zika virus	9
interstitial lung	9
mice lacking	9
long term	9
traumatic stress	9
natural science	9
normal human	9
beneficial effect	9
met signaling	9
significantly improved	9
focal adhesion	9
lung fibrosis	9
lower respiratory	9
intracranial pressure	8
sars patients	8
statistical analyses	8
severe ards	8
tight junction	8
different cell	8
also reduced	8
lps induces	8
knockdown mice	8
brain dysfunction	8
time rt	8
binding proteins	8
organ damage	8
also significantly	8
graphpad prism	8
core degs	8
independent risk	8
cause ali	8
inflammasome activity	8
edema associated	8
i cells	8
activator protein	8
inflammatory mediator	8
mice per	8
lpsinduced ali	8
oxygen partial	8
ii epithelial	8
confocal microscopy	8
hiv aids	8
also used	8
patients required	8
null mice	8
cell survival	8
rho gtpases	8
sepsis campaign	8
molecular mechanism	8
macrophage colony	8
alveolar oedema	8
factor alpha	8
diurnal changes	8
kappab activation	8
vital signs	8
alo monolayers	8
total number	8
small intestine	8
acute brain	8
differential diagnosis	8
wistar rats	8
investigate whether	8
attractive target	8
nitrated rac	8
circulating neutrophils	8
cell damage	8
granted medrxiv	8
chemoattractant protein	8
normal saline	8
airspace edema	8
lps exposure	8
international cohort	8
enter cells	8
human respiratory	8
five patients	8
lung protective	8
higher expression	8
rna viruses	8
ace expression	8
wet weight	8
work reveals	8
icu discharge	8
defense mechanisms	8
ventilator settings	8
induced ec	8
author funder	8
poor outcome	8
neutralizing antibody	8
study suggests	8
human colon	8
marrow mscs	8
data indicate	8
culture medium	8
murine models	8
gene ontology	8
day group	8
thrombin receptor	8
several polymorphisms	8
acute phase	8
receptor agonists	8
significant higher	8
adrenergic agonists	8
eicosapentaenoic acid	8
liver organoids	8
ill patient	8
age years	8
pathway using	8
conditioned media	8
respiratory infection	8
blocking buffer	8
vascular hyperpermeability	8
ventilation strategy	8
differential metabolites	8
disease severity	8
low levels	8
may help	8
cytokine il	8
clinical investigations	8
intratracheal injection	8
lung macrophages	8
complex formation	8
expiratory flow	8
target genes	8
wash buffer	8
injury mice	8
kidney organoids	8
brain injury	8
mortality prediction	8
extracellular pbef	8
reduced expression	8
hydrogen peroxide	8
granulocyte colony	8
serum tnf	8
requiring mechanical	8
cultured cells	8
protein substrates	8
neutrophil sequestration	8
vascular integrity	8
international license	8
analysis revealed	8
viral infectivity	8
inflammasome formation	8
neutrophil migration	8
healthy controls	8
endosome pathway	8
tipe treatment	8
tlr trif	8
showed significant	8
findings suggest	8
palm gene	8
mediated inflammation	8
injury group	8
also shown	8
short hairpin	8
ljf groups	8
quantified using	8
lower mortality	8
low tidal	8
two studies	8
ttp overexpression	8
post hoc	8
cell carcinoma	8
pulmonary embolism	8
four patients	8
magnesium sulphate	8
inclusion criteria	8
lps treatment	8
orally inhaled	8
animal experiments	8
proteomic analysis	8
mass spectrometry	8
clinical outcome	8
mice infected	8
various cell	8
nutrition support	8
live rats	8
nuclear extracts	8
tumor suppressor	8
bca protein	8
viral rna	8
cells per	8
serum amyloid	8
linkage disequilibrium	8
might also	8
activating factor	8
cell niche	8
randomly assigned	8
confocal images	8
viral replication	8
clinical evidence	8
angiotensin i	8
matrix metalloproteinases	8
receptor potential	8
treat covid	8
mitochondrial transfer	8
signaling cascades	8
related genes	8
induced increases	8
air embolism	8
natural killer	8
human neutrophil	8
nervous system	8
therapeutic efficacy	8
patient population	8
injury following	8
vitro studies	8
canine model	8
year period	8
study indicates	8
hospital length	8
acid injection	8
eff ective	8
experimental design	8
regulatory factor	8
molecular targets	8
mediated lung	8
specific ttp	8
colon cancer	8
may affect	8
like cells	8
patients presented	8
pleural effusion	8
transmembrane conductance	8
based nams	8
sepsis induced	8
human subjects	8
novel biomarker	8
angiotensin receptor	8
barrier protection	8
less likely	8
induced barrier	8
ovarian cancer	8
dysfunction syndrome	8
vegf levels	8
protein concentrations	8
via inhibiting	8
pattern recognition	8
rabbit polyclonal	8
normal range	8
expression omnibus	8
studies showed	8
based lipid	8
high power	8
elderly patients	8
serum albumin	8
vitro expansion	8
induced tlr	8
bronchioalveolar stem	8
early endosome	8
plasma concentration	8
mice lungs	8
severe ali	8
successfully used	8
give rise	8
antioxidant supplementation	8
ion transport	8
genetic material	8
genome editing	8
perivascular edema	8
per year	8
mg day	8
genetic factors	8
inhibition group	8
cord blood	8
polyunsaturated fatty	8
treat ali	8
human pluripotent	8
significant decrease	8
studies suggest	8
tlr inhibition	8
organoid models	8
first day	8
colony enhancing	7
derived factor	7
also increased	7
severe septic	7
single cells	7
descriptive study	7
actin ring	7
recipient mice	7
gene family	7
bovine serum	7
pbef neutralizing	7
brush border	7
apical surface	7
comorbid medical	7
infarct size	7
findings indicate	7
alveolar septal	7
lung injuries	7
may infl	7
lactate requests	7
icu ventilators	7
cells derived	7
therapeutic options	7
genetic predisposition	7
ali vs	7
lactate levels	7
single cell	7
conditioned medium	7
kinase gene	7
respiratory muscles	7
septic animals	7
tlr ligands	7
sample size	7
leading cause	7
also demonstrated	7
significant increases	7
adrenergic receptor	7
thromboplastin time	7
canine models	7
significantly associated	7
base excess	7
base pairs	7
stromal cell	7
mice showed	7
cell differentiation	7
isolated lungs	7
non invasive	7
organoids culture	7
transmission electron	7
survival rates	7
curcuma longa	7
epidemiologic studies	7
preclinical studies	7
i interferon	7
alveolar capillary	7
relative expression	7
physiology score	7
induced apoptosis	7
lung model	7
gas analysis	7
anticoagulant effects	7
ttp levels	7
inflammatory processes	7
pilot study	7
life technologies	7
exclusion criteria	7
respiratory insufficiency	7
intestinal epithelial	7
host inflammation	7
final manuscript	7
underlying ali	7
rna interference	7
endogenous stem	7
highly expressed	7
tolllike receptor	7
actin filaments	7
niv mode	7
fat embolism	7
hepatocellular injury	7
factor viia	7
nlrp pathway	7
organoids using	7
histological examination	7
ali remains	7
surfactant proteins	7
pmn nad	7
per well	7
required mechanical	7
still remains	7
simplified acute	7
pulsatility index	7
experimental sepsis	7
neutrophil counts	7
human macrophages	7
nlrp asc	7
fibroproliferative phase	7
regenerative medicine	7
major causes	7
blue dye	7
viral entry	7
nlrp activation	7
poor correlation	7
pulmonary organ	7
future studies	7
may provide	7
experimental study	7
may occur	7
chronic renal	7
much less	7
positive bacteria	7
chemokine receptor	7
general icu	7
sham group	7
relevant outcomes	7
may serve	7
markedly attenuated	7
inflammatory reactions	7
chest pain	7
medical records	7
including il	7
general wards	7
cells within	7
promoter polymorphism	7
lung infl	7
prone positioning	7
partial thromboplastin	7
copyright holder	7
multicenter study	7
immunofluorescence staining	7
graphpad software	7
results show	7
antiviral response	7
admission diagnosis	7
induced septic	7
hospitalized patients	7
intravascular coagulation	7
macrophage activation	7
least three	7
stimulated afc	7
receptor blockers	7
rescue therapies	7
differentiated human	7
ards ali	7
antimicrobial peptides	7
serine protease	7
novel therapies	7
poorly understood	7
blood barrier	7
randomly divided	7
neutrophilic lung	7
specific protease	7
following ali	7
drug administration	7
study also	7
clinical manifestations	7
cov infection	7
low dose	7
adenosine monophosphate	7
genetic information	7
repair process	7
four hours	7
small airway	7
center study	7
primary outcome	7
goat anti	7
nucleic acid	7
associated acute	7
transgene expression	7
study design	7
late endosome	7
inhibitory effects	7
significant association	7
vegfr mrna	7
target range	7
lung infections	7
rapid response	7
type cells	7
pancreatic ductal	7
injury may	7
effi cient	7
basic science	7
recent evidence	7
activated neutrophils	7
confidence interval	7
small intestinal	7
bal protein	7
well known	7
pulmonary infiltrates	7
failure due	7
enhanced cleaning	7
related quality	7
genes related	7
data showed	7
splen groups	7
brain organoids	7
surfactant therapy	7
kidney disease	7
myocardial ischemia	7
iron content	7
human tissues	7
will help	7
independently associated	7
pancreatic cancer	7
preclinical animal	7
mortality benefit	7
ali method	7
two different	7
term expansion	7
potential targets	7
stress doses	7
routinely used	7
promising results	7
data collection	7
decreased expression	7
conductance regulator	7
wet lung	7
onset severe	7
potential role	7
liver transplantation	7
surfactant system	7
flow rate	7
group treated	7
postoperative period	7
fluid reabsorption	7
study shows	7
associated proteins	7
markedly elevated	7
inflammatory disease	7
artery bypass	7
endosomal pathway	7
induced neutrophil	7
pulmonary infection	7
zfp flox	7
tumour necrosis	7
blood neutrophils	7
blood vessel	7
studies reported	7
pulmonary expression	7
lung epithelium	7
total body	7
clinical setting	7
eff ects	7
mucociliary clearance	7
induce ali	7
following lps	7
post ali	7
enteral feeding	7
myeloid differentiation	7
nucleotide polymorphism	7
seq results	7
permeability pulmonary	7
induced endothelial	7
receptor expression	7
epithelial fluid	7
new therapeutic	6
severe asthma	6
fluid resuscitation	6
cultured human	6
improved outcomes	6
last years	6
enzyme gene	6
rectal cancer	6
adherens junctions	6
sphingosine kinase	6
ctrl group	6
many patients	6
treatment option	6
th ese	6
controlled study	6
ali induction	6
ubiquitin chains	6
help identify	6
therapeutic agent	6
association study	6
drug response	6
lps ad	6
per high	6
generate tumors	6
significantly downregulated	6
human ipsc	6
attenuates endotoxin	6
aud patients	6
antioxidant therapy	6
box protein	6
common genetic	6
ifn signaling	6
improved cardiac	6
marrow mesenchymal	6
ovariectomized rats	6
respiratory mechanics	6
fl uid	6
endotoxic shock	6
european descent	6
hepatocellular carcinoma	6
per patient	6
fl fl	6
two types	6
sustained viral	6
also reported	6
cutting edge	6
closely related	6
histological changes	6
kinase activation	6
neutrophilic infiltration	6
crucial role	6
genetic recombination	6
combination therapy	6
jaam dic	6
tnf therapy	6
ali risk	6
serum lactate	6
included patients	6
authors read	6
profi le	6
network pharmacology	6
lipid emulsion	6
mechanisms involved	6
receiving mechanical	6
basic research	6
corresponding ali	6
vascular injury	6
liver disease	6
hepcidin expression	6
mice received	6
cells may	6
interferon signaling	6
baseline levels	6
modified score	6
regulated protein	6
protects mice	6
treated patients	6
first line	6
trial coordination	6
reduced mortality	6
ali may	6
inspiratory muscle	6
respiratory dysfunction	6
exosomes derived	6
fi brinogen	6
tissue sections	6
gov identifier	6
decreased mortality	6
inflammasome pathway	6
ly i	6
retinoic acid	6
cancer cell	6
antimicrobial therapy	6
mediates lung	6
extracellular signal	6
tlr upregulation	6
human monocytes	6
clinical review	6
traf traf	6
rats treated	6
small interfering	6
tumor microenvironment	6
retrospective analysis	6
prism software	6
adherens junction	6
cell motility	6
normal organoids	6
recognition receptors	6
challenged flox	6
pulmonary dead	6
patients requiring	6
response team	6
interferon regulatory	6
single lgr	6
signal transducer	6
jnk activation	6
su treated	6
urine output	6
tight junctions	6
mechanisms underlying	6
personalized treatment	6
lps groups	6
lung repair	6
enrichment analysis	6
negative effects	6
severe pulmonary	6
rodent model	6
carotid artery	6
prospectively collected	6
better understanding	6
fold change	6
palm knockdown	6
low doses	6
quantitative analysis	6
target cells	6
heparin dosage	6
multivariate logistic	6
ventilation strategies	6
pufa administration	6
embryonic stem	6
positive findings	6
receiver operating	6
organoid biobank	6
case report	6
chest radiograph	6
master mix	6
successfully established	6
positive airway	6
transcriptional regulation	6
mast cells	6
akt pathway	6
interacting protein	6
chronic lung	6
epithelial permeability	6
mechanism underlying	6
ammatory cytokines	6
early stages	6
purified using	6
family members	6
induced changes	6
activated partial	6
human small	6
bronchopulmonary dysplasia	6
disease models	6
cell permeability	6
early identification	6
treated group	6
iron metabolism	6
ali rats	6
gel electrophoresis	6
also involved	6
alveolar septum	6
inflammatory stimuli	6
identifier nct	6
aav vector	6
clinical isolate	6
human ali	6
may cause	6
score ii	6
improved oxygenation	6
pneumococcal pneumonia	6
clinical problem	6
aec cell	6
vivo net	6
congestive heart	6
chronic health	6
gene approach	6
odds ratio	6
capillary leak	6
reduced levels	6
tertiary referral	6
kg body	6
dry ratio	6
primary antibody	6
pbef expression	6
neutralizing antibodies	6
functional repair	6
interim analysis	6
lung specimens	6
mylk gene	6
protein content	6
humanized anti	6
cell receptor	6
alveolar injury	6
cohort studies	6
dark cycle	6
established ards	6
notch signaling	6
using western	6
therapeutic intervention	6
cftr function	6
study aimed	6
cre zfp	6
tissue plasminogen	6
conjugated secondary	6
sepsis guideline	6
protein kinases	6
influenza group	6
containing adaptor	6
promising potential	6
zn levels	6
animal study	6
focal adhesions	6
immune cell	6
clinically significant	6
european consensus	6
endoplasmic reticulum	6
ali mouse	6
viral load	6
clinical symptoms	6
care facilities	6
bacterial pneumonia	6
ii alveolar	6
severe community	6
pulmonary inflammatory	6
environmental factors	6
mediated endothelial	6
neutrophils purified	6
attenuates lipopolysaccharide	6
chest radiography	6
related ali	6
control groups	6
unpaired two	6
patients often	6
normally distributed	6
proliferated cells	6
actin stress	6
actin polymerization	6
poor prognosis	6
helicobacter pylori	6
stellate injection	6
publicly available	6
gold standard	6
derived intestinal	6
two distinct	6
higher rate	6
polymorphonuclear neutrophils	6
high mobility	6
care doi	6
organoids model	6
lactic acidosis	6
ace levels	6
frequency oscillatory	6
soluble intercellular	6
patients underwent	6
translational research	6
associated protein	6
consensus conference	6
patient ventilator	6
important mechanism	6
murine lung	6
tipe lps	6
potential novel	6
cerebral compression	6
multiorgan failure	6
animal research	6
higher peep	6
cytometry analysis	6
urban areas	6
parenteral nutrition	6
inhaled drugs	6
shorter duration	6
blood lactate	6
regulating vascular	6
laboratory animal	6
organic acids	6
chi square	6
effector domain	6
washed twice	6
ali via	6
extracellular atp	6
ethnic groups	6
patients using	6
ii receptor	6
oscillatory ventilation	6
experimental data	6
hepcidin gene	6
total cells	6
serious adverse	6
spike protein	6
atp release	6
alveolar hemorrhage	6
bal fluids	6
human endothelial	6
japanese encephalitis	6
play important	6
matched normal	6
molecular subtypes	6
mononuclear cells	6
general hospital	6
twice daily	6
septic aki	6
may reduce	6
significant improvement	6
mouse models	6
whitney test	6
studies examining	6
complement system	6
cardiac surgical	6
respiratory support	6
intravenous injection	6
dependent cytoskeletal	6
paracellular gap	6
rna sequencing	6
van der	6
dub family	6
gastric organoids	6
mean values	6
mice exhibit	6
life support	6
power field	6
ventilator days	6
cumulative fb	6
cell lung	6
phosphorylated mlc	6
attenuated lps	6
serum creatinine	6
inflammatory gene	6
reverse transcription	6
enhanced expression	6
inhibitory effect	6
organ failures	6
fully understood	6
lung homogenate	6
prone position	6
peroxisome proliferator	6
ubiquitinated protein	6
perivascular inflammation	6
national natural	6
interfacility transfers	6
blood transfusion	6
colon organoids	6
curcumin reduced	6
buffered formalin	6
related mortality	6
genetically engineered	6
lung sections	6
airway cells	6
circadian oscillations	6
transgenic mice	6
cell activation	6
staphylococcus aureus	6
patients may	6
provide evidence	6
lung liquid	6
research tool	6
vagus nerve	6
inos mrna	6
tlr activation	6
three patients	6
sequencing data	6
studies using	6
treatment group	6
randomised controlled	6
cells overexpressing	6
intestinal ischemia	5
patient outcome	5
related molecules	5
pmn infiltration	5
lactate level	5
sample sizes	5
observer reliability	5
overt dic	5
growing body	5
receptor family	5
cause mortality	5
modifi ed	5
attenuated lung	5
cell gap	5
novel role	5
clinical conditions	5
patients older	5
commercially available	5
sepsis syndrome	5
statin therapy	5
active lung	5
proteasomal degradation	5
hepcidin level	5
rac inhibition	5
weight loss	5
body mass	5
muramyl dipeptide	5
fluid therapy	5
serine proteases	5
might contribute	5
soft tissue	5
flap region	5
also examined	5
significantly upregulated	5
erythema nodosum	5
nosocomial infection	5
ad libitum	5
epithelial progenitor	5
der gesundheitsbezogenen	5
ct scan	5
patient demographics	5
oid testing	5
tissue homogenates	5
nr ab	5
end expiratory	5
polymorphonuclear leukocytes	5
cancer patients	5
dex group	5
septic group	5
previously reported	5
patients died	5
abdominal incision	5
values less	5
epithelial monolayer	5
negative selection	5
received mechanical	5
normal level	5
ameliorates lipopolysaccharide	5
experimental acute	5
detrimental role	5
markedly reduced	5
high tidal	5
consecutive days	5
early postoperative	5
specific pathogen	5
berlin definition	5
stress fiber	5
epithelial stem	5
disease processes	5
immunocompromised mice	5
surgical wards	5
enzyme insertion	5
alveolar flooding	5
shock may	5
statistical difference	5
induced airway	5
experimental models	5
may result	5
mouse neutrophils	5
irradiated ttp	5
positive staining	5
initial treatment	5
significant neutrophil	5
mortality reduction	5
lymphocyte counts	5
lps injection	5
negative predictive	5
aa ratios	5
cytoskeletal changes	5
socs expression	5
hepatic function	5
dry ratios	5
human gastric	5
mpo granule	5
translational modification	5
may allow	5
forming capacity	5
methods section	5
see table	5
cationic lipid	5
correlation coefficient	5
fluid responsiveness	5
cell isolation	5
alveolar cell	5
protein family	5
studies found	5
lps instillation	5
allergic airway	5
ammatory cytokine	5
vegf gene	5
ang ii	5
collected data	5
derived growth	5
therapeutic regimen	5
inflammatory reaction	5
using real	5
disseminated intravascular	5
oid deposition	5
neutrophil chemoattractants	5
mixed medical	5
i ifn	5
enhancing effect	5
polyvinylidene difluoride	5
autoimmune disease	5
older age	5
cognitive dysfunction	5
strongly associated	5
transcriptional changes	5
several clinical	5
procoagulant molecules	5
protein stability	5
volume ventilation	5
representative confocal	5
active compounds	5
lung transplantation	5
wide association	5
blood sample	5
multiple testing	5
organoid biobanks	5
multiple organs	5
specific forms	5
intratracheally administered	5
multiple transfusions	5
murine macrophages	5
cell numbers	5
total hospital	5
weaning criteria	5
pathogenic viral	5
left lung	5
enrolled patients	5
medical center	5
ct scans	5
anova followed	5
ali initiation	5
isolated perfused	5
clinical management	5
injury models	5
rad laboratories	5
phosphatebuffered saline	5
normal control	5
groups increased	5
capillary bed	5
non parametric	5
human liver	5
derived monolayers	5
neutrophil exudation	5
enteral formula	5
med doi	5
asc caspase	5
meoh meoh	5
mitochondrial function	5
including immune	5
perfused rat	5
bipap vision	5
experimental model	5
droplets particles	5
old patients	5
functional outcome	5
major histocompatibility	5
studies will	5
related diseases	5
cord mesenchymal	5
inflammatory activity	5
iii clinical	5
various types	5
washed three	5
syndrome network	5
including lung	5
treatment improves	5
neutrophil function	5
neutrophil numbers	5
direct causes	5
endothelial cadherin	5
cells also	5
influenza pandemic	5
tunel staining	5
cases per	5
monocyte chemoattractant	5
cell suspensions	5
cardiovascular system	5
one patients	5
may exert	5
syndrome pulmonary	5
receptor signalling	5
clara cell	5
burn patients	5
reduced plasma	5
study examining	5
glasgow coma	5
significant changes	5
prosthetic valve	5
injury patients	5
coma scale	5
log rank	5
transport across	5
androgen receptor	5
fi brinolysis	5
health evaluation	5
bacterial clearance	5
transendothelial migration	5
cytokines including	5
blood lymphocytes	5
fluid challenge	5
future research	5
clinical utility	5
terminal hydrolases	5
intratracheal lps	5
melatonin treatment	5
lung biopsies	5
seven patients	5
original magnification	5
pancreatic organoids	5
free access	5
mediated knock	5
cpa patients	5
antigen receptor	5
volume mechanical	5
cytokine expression	5
comparison test	5
ace gene	5
representative photomicrographs	5
cftr channel	5
ventricular function	5
susceptibility gene	5
cellular barrier	5
adaptor inducing	5
underlying disease	5
adaptive immunity	5
quality control	5
damage induced	5
systemic diseases	5
derived human	5
type neutrophils	5
clinical significance	5
imaging system	5
rifle criteria	5
dubs might	5
rectal organoids	5
negative regulation	5
intensivmedizinischen behandlung	5
aids patients	5
dha aa	5
tract infection	5
dexamethasone group	5
main active	5
time quantitative	5
may improve	5
one hour	5
lung mpo	5
target cell	5
lung section	5
blood cell	5
cell lysis	5
cell sorting	5
ards secondary	5
proteome changes	5
phagocytic cells	5
severe inflammation	5
competence assessment	5
assess whether	5
many types	5
post lps	5
randomized trial	5
signifi cantly	5
developing ards	5
mortality risk	5
conjugating enzymes	5
lpschallenged ttp	5
oxidative burst	5
rank test	5
expression patterns	5
cell organoids	5
well plates	5
assessed using	5
study provides	5
injury role	5
membrane formation	5
care services	5
induced cell	5
hemodynamic changes	5
cerebral hyperperfusion	5
last decade	5
mice exhibited	5
deceased covid	5
drug sensitivity	5
well tolerated	5
common causes	5
semiquantitative histopathological	5
clinical application	5
possible molecular	5
world health	5
large surface	5
first interim	5
large numbers	5
novel mechanism	5
histocompatibility complex	5
enhanced chemiluminescence	5
trend towards	5
histopathological scoring	5
inhibiting nlrp	5
death effector	5
circuit life	5
failure assessment	5
accession number	5
prognostic factors	5
among groups	5
hospital admission	5
cells following	5
light cycle	5
following admission	5
novel therapeutics	5
elisa assay	5
excessive inflammatory	5
blotting analysis	5
ii modified	5
factors associated	5
rat liver	5
histological subtypes	5
edema resolution	5
shock group	5
mortality data	5
restore lung	5
valve replacement	5
clinical implications	5
hematopoietic stem	5
intensive insulin	5
often associated	5
trif protein	5
demographic characteristics	5
shock admitted	5
airway components	5
specific inhibitor	5
rabbit igg	5
antigen retrieval	5
muscle mlck	5
arterial hypertension	5
one year	5
patients needed	5
endogenous surfactant	5
pneumoniae infection	5
apoptotic cells	5
new insights	5
one study	5
total volume	5
retrospective review	5
saline group	5
multiple genes	5
superoxide dismutase	5
elisa kits	5
authors reported	5
autologous transplantation	5
public health	5
extracellular dna	5
urinary tract	5
adenoviral gene	5
stroke volume	5
plasma vegf	5
every patient	5
male wistar	5
respiratory epithelium	5
blood volume	5
muc ac	5
alo lines	5
fi brin	5
decreased lung	5
way analysis	5
binding sites	5
inducing interferon	5
high vascular	5
pufa supply	5
previous report	5
peer review	5
medical university	5
like protein	5
sepsis group	5
rich edema	5
capsid proteins	5
new treatment	5
indirect injury	5
independent predictor	5
expression analysis	5
mapk family	5
active caspase	5
previous findings	5
right panel	5
granulocyte macrophage	5
expression profiles	5
older patients	5
cognitive decline	5
patients suffered	5
five datasets	5
cellular kinetics	5
intravital imaging	5
potentially important	5
marrow stromal	5
vivo experiments	5
mucociliary epithelium	5
causative bacteria	5
marrow chimeras	5
eines ptsd	5
operated control	5
organoid model	5
mixed venous	5
cruz biotechnology	5
venous pressure	5
prolonged mechanical	5
human recombinant	5
crystal structure	5
human development	5
cross talk	5
cellular processes	5
results demonstrate	5
survival benefit	5
data support	5
murine sepsis	5
precision medicine	5
infection causes	5
surface tension	5
protective strategies	5
mean duration	5
disease progression	5
enteral diet	5
possible therapeutic	5
reduce lung	5
well established	5
health organization	5
randomized clinical	5
placebo group	5
diseases including	5
retrospective cohort	5
parenteral administration	5
ards patient	5
intubated patients	5
right ventricular	5
cyclic adenosine	5
induced systemic	5
pars expression	5
ill adults	5
predisposing factors	5
isth overt	5
mice via	5
guinea pigs	5
tissue culture	5
serum procalcitonin	5
key component	5
tissue oxygen	5
process following	5
study conducted	5
exudative phases	5
specifi city	5
whole lung	5