bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
amino acid	924
amino acids	884
mannich bases	841
mg kg	609
cell lines	606
results suggest	500
antiviral activity	488
antimicrobial activity	473
present study	455
antibacterial activity	451
mg ml	424
inhibitory activity	412
cell line	408
gene expression	397
oxidative stress	395
cancer cells	363
biological activity	360
natural products	317
physical activity	316
essential oils	299
breast cancer	295
cell death	292
important role	287
antioxidant activity	283
antimicrobial peptides	282
antifungal activity	275
research funds	268
cancer cell	266
active site	260
mass spectrometry	257
control group	246
nervous system	219
cell proliferation	218
pomegranate juice	218
reference drug	217
results indicate	214
escherichia coli	204
molecular weight	202
graduate school	199
wild type	195
dependent manner	194
essential oil	193
biological activities	191
fatty acids	190
results showed	189
psoralea corylifolia	189
protein kinase	186
wide range	186
ic values	184
binding site	184
cell cycle	183
influenza virus	178
spinal cord	176
inhibitory effect	175
medicinal plants	172
ng ml	169
nitric oxide	166
solid phase	165
side chain	160
side effects	160
cell surface	160
prostate cancer	159
endothelial cells	157
enzyme activity	156
cell membrane	154
reactive oxygen	154
mannich base	153
staphylococcus aureus	152
widely used	149
plasma membrane	149
previous studies	149
stem cells	148
growth factor	146
dna damage	145
oxygen species	144
punica granatum	144
peptide synthesis	141
tumor cells	140
protein expression	140
central nervous	139
blood pressure	138
clinical trials	137
fatty acid	136
transcription factor	136
acid residues	136
lipid peroxidation	136
two different	135
immune system	135
antimicrobial peptide	135
creative tourism	134
herpes simplex	132
molecular mechanisms	132
signi fi	132
cell culture	132
type i	131
significantly increased	131
immune response	130
negative bacteria	129
secondary structure	127
results show	127
mrna expression	126
significantly higher	126
western blot	125
signal transduction	125
recent studies	125
cell viability	124
coumarin derivatives	122
plant extracts	121
first day	121
transcription factors	121
molecular dynamics	120
inhibitory effects	119
flow cytometry	118
body weight	117
studies showed	116
simplex virus	116
cordyceps sinensis	115
naturally occurring	115
binding sites	114
trypsin inhibitor	114
cell cultures	113
doc id	112
cord uid	112
large number	112
signaling pathways	111
protein synthesis	111
biologically active	111
significant difference	110
binding protein	108
secondary metabolites	108
bioactive compounds	107
cell wall	107
activity relationship	107
recent years	107
high affinity	106
smooth muscle	106
cell growth	106
molecular docking	105
side chains	104
ms ms	103
antiviral agents	103
affi nity	103
oral administration	103
expression levels	102
blood samples	102
data suggest	102
also found	102
epithelial cells	102
significant increase	102
antiviral activities	101
national institute	100
reverse transcriptase	99
platelet aggregation	99
crystal structure	98
positive bacteria	98
diabetes mellitus	98
rna chaperone	97
analysis revealed	97
results obtained	97
cell adhesion	97
membrane proteins	96
type ii	96
antimicrobial activities	95
statistically significant	95
previously reported	95
significantly reduced	94
taken together	94
serine protease	94
lg ml	94
biological evaluation	94
significant differences	93
first time	93
cytotoxic activity	93
conformational changes	93
gel electrophoresis	92
also known	92
different types	91
well known	91
mouse model	91
ic value	91
mammalian cells	90
virus replication	90
th day	90
significantly decreased	90
also showed	90
acid sequence	89
active compounds	89
protease inhibitors	88
bases derived	88
animal models	88
type diabetes	88
radical scavenging	88
binding affinity	87
protein interactions	87
signaling pathway	87
risk factors	87
terminal domain	87
inflammatory activity	86
mic values	86
protective effect	86
key role	86
electron microscopy	85
drug resistance	85
drug discovery	85
results indicated	85
free radical	85
candida albicans	85
growth inhibition	85
antimicrobial agents	85
dna binding	84
membrane potential	84
chaperone activity	83
commonly used	83
phenolic compounds	83
present work	83
ca i	83
nmr spectroscopy	83
may play	83
modifi ed	83
mycobacterium tuberculosis	83
may contribute	81
activity relationships	81
enzymatic activity	81
small molecule	81
performed using	81
chemical composition	81
lung cancer	81
amino group	81
human rhinovirus	80
liquid chromatography	80
diabetic rats	80
virus type	80
cell types	80
public health	80
phase peptide	80
broad spectrum	80
pomegranate fruit	79
superoxide dismutase	79
stem cell	79
viral infections	78
cerebral cortex	78
activated protein	78
commercially available	78
anticancer activity	78
antimalarial activity	77
hydroxyl group	77
findings suggest	77
therapeutic agents	77
low molecular	77
circular dichroism	77
molecular biology	77
fold higher	77
hela cells	76
fi rst	76
phenolic mannich	76
rat brain	76
heart failure	76
also observed	76
progenitor cells	76
wistar rats	76
results suggested	75
antioxidant capacity	75
eucalyptus camaldulensis	75
membrane protein	75
showed significant	75
docking studies	75
expression level	74
virus infection	74
highly conserved	74
protein levels	74
drug delivery	73
negatively charged	73
blood glucose	73
neuronal activity	73
tumor cell	73
metal ions	73
small molecules	73
mannich reaction	73
vitro activity	72
synthesized compounds	72
insulin resistance	72
necrosis factor	72
may also	72
research institute	72
living cells	72
binding domain	71
colon cancer	71
building blocks	71
viral replication	71
chemical synthesis	71
ellagic acid	71
neurodegenerative diseases	71
fi cantly	71
high levels	70
affinity chromatography	70
inhibitory concentration	70
functional groups	70
angiotensin ii	70
seed oil	70
gallic acid	70
catalytic activity	69
plasmodium falciparum	69
first step	69
infectious diseases	69
antiproliferative activity	69
closely related	69
high activity	69
assay system	69
purkinje cells	69
colorectal cancer	69
bacillus subtilis	69
protein structure	68
marine natural	68
blot analysis	68
receptor antagonist	68
infected cells	68
nmda receptor	68
host cells	68
converting enzyme	68
respiratory tract	68
skeletal muscle	67
compounds showed	67
new class	67
immunodeficiency virus	67
human breast	67
hippocampal neurons	66
significantly lower	66
coupled receptors	66
united states	66
analysis showed	66
bone marrow	66
adverse effects	66
synthetic peptides	66
recombinant protein	66
positive control	66
extracellular matrix	65
different concentrations	65
drug development	65
three different	65
natural compounds	65
also used	65
resistant strains	65
scavenging activity	65
cyclic peptides	65
cell migration	65
antitumor activity	65
prefrontal cortex	64
pseudomonas aeruginosa	64
knockout mice	64
ecklonia cava	64
data indicate	64
nucleic acid	64
serine proteases	64
binding proteins	64
mechanisms underlying	64
lactic acid	64
determined using	64
identifi ed	64
crucial role	63
model system	63
saccharomyces cerevisiae	63
protein kinases	63
human immunodeficiency	63
synaptic transmission	63
molecular mass	63
transgenic mice	63
nuclear factor	62
host cell	62
cell membranes	62
kg day	62
poorly understood	62
silver nanoparticles	62
tumor necrosis	62
carboxylic acid	62
potent inhibitors	62
brain science	62
weight loss	62
molecular mechanism	62
vitro studies	61
synthetic peptide	61
phenyl ring	61
day compared	61
receptor binding	61
whole blood	61
deficient mice	61
results demonstrate	61
bglu activity	61
current study	61
animal model	61
human plasma	61
fusion protein	61
fl uorescence	60
western blotting	60
viral rna	60
positively charged	60
drug design	60
protease activity	60
situ hybridization	60
time pcr	60
effi cient	59
acute respiratory	59
lipid bilayer	59
myocardial infarction	59
acetic acid	59
muscle cells	59
acid derivatives	59
phase synthesis	59
ang ii	59
signifi cant	59
antifungal activities	59
mtt assay	58
visual cortex	58
cytotoxic effects	58
protective effects	58
previous study	58
viral infection	58
enzyme activities	58
cellular processes	58
hek cells	58
antiviral drugs	58
less active	58
studies revealed	57
substrate specificity	57
respiratory syndrome	57
fi cant	57
therapeutic potential	57
important roles	57
results revealed	57
several studies	57
derivatives synthesis	57
may lead	57
common cold	57
cortical neurons	56
pomegranate extract	56
protein folding	56
magnetic resonance	56
induced apoptosis	56
antiviral effects	56
may provide	56
antioxidant properties	56
another study	56
potent anti	56
heat shock	55
fruit extract	55
hydrogen peroxide	55
risk factor	55
antibacterial activities	55
fold increase	55
medicinal plant	55
plant species	55
ethyl acetate	55
ligand binding	55
pc cells	55
atpase activity	55
conformational change	55
antiviral effect	55
bacterial cell	55
compound showed	55
antioxidant activities	55
traditional chinese	54
target protein	54
peripheral blood	54
purifi cation	54
food intake	54
cancer patients	54
pathogenic bacteria	54
tested compounds	54
evaluated using	54
antimycobacterial activity	54
amine reagents	54
two groups	54
newly synthesized	54
human lung	54
specifi city	54
clinical studies	53
free radicals	53
endoplasmic reticulum	53
biological properties	53
structural features	53
hepg cells	53
technical university	53
antibacterial agents	53
specific activity	53
monoclonal antibody	53
pharmacological activities	53
critical role	53
monoclonal antibodies	53
galla chinensis	53
neural stem	53
low concentrations	53
tyrosine kinase	53
rheumatoid arthritis	53
mrna levels	53
synaptic plasticity	53
significant reduction	52
antimicrobial properties	52
modifi cation	52
heart rate	52
terminal region	52
tandem mass	52
biological processes	52
inflammatory cytokines	52
natural product	52
directed mutagenesis	51
high throughput	51
treated cells	51
brown alga	51
significant decrease	51
wound healing	51
brain regions	51
widely distributed	51
rna polymerase	51
investigated using	51
small intestine	51
group i	51
platelet activation	51
recombinant proteins	51
purifi ed	51
life cycle	51
real time	51
peptide bond	51
positive cells	51
ion channels	51
inflammatory response	51
pregnant women	51
human health	51
potent inhibitor	50
preliminary results	50
factor viii	50
human cancer	50
antimicrobial potential	50
two new	50
new compounds	50
hepatocellular carcinoma	50
bacterial strains	50
estrogen receptor	50
vitro anti	50
protein complexes	50
even though	50
pomegranate seed	50
aromatic ring	50
osaka univ	50
inhibition zone	50
also reported	49
university graduate	49
toxic effects	49
highly selective	49
volatile oils	49
using different	49
virus activity	49
ascorbic acid	49
solid support	49
major role	49
hydrogen bonding	49
immune responses	49
human cells	49
protein level	49
higher activity	49
chemical engineering	49
wide variety	49
low toxicity	48
neuronal cells	48
peptides containing	48
induced diabetic	48
kyoto university	48
infl uence	48
high concentrations	48
ko mice	48
also investigated	48
proteins involved	48
aspartic acid	48
bioactive peptides	48
traditional medicine	48
room temperature	48
vivo studies	48
rhus chinensis	48
nucleic acids	48
intrinsically disordered	48
healthy subjects	48
high level	48
structural analysis	48
related compounds	48
chinese medicine	47
granule cells	47
two types	47
blood cells	47
glutamic acid	47
high resolution	47
activity towards	47
cytotoxic effect	47
beneficial effects	47
pharmacological properties	47
crystal structures	47
severe acute	47
last years	47
adipose tissue	47
cov clpro	47
culture medium	47
inhibitory activities	47
dynamics simulations	47
medicinal chemistry	47
thermal stability	47
hydrogen bonds	47
acid sequences	47
dna repair	47
target cells	46
vaccinia virus	46
induced cell	46
research center	46
neurite outgrowth	46
anticonvulsant activity	46
proteolytic activity	46
aqueous solution	46
secondary structures	46
multiple sclerosis	46
marine sponge	46
phenolic acids	46
endothelial cell	46
standard drug	46
full length	46
sequence analysis	46
plasma samples	46
diffusion method	46
aspergillus niger	46
modifi cations	46
structural changes	46
less potent	45
male rats	45
hydrogen bond	45
similar results	45
trypsin inhibitors	45
activity compared	45
showed high	45
tumor growth	45
pyramidal neurons	45
university school	45
new drugs	45
identifi cation	45
dengue virus	45
cell survival	45
allowed us	45
study showed	45
see footnote	45
target genes	45
systematic review	45
density lipoprotein	45
biofilm formation	45
better understanding	45
neuropathic pain	45
human body	45
neuronal cell	45
rat model	45
significantly different	45
innate immunity	44
highly active	44
activity levels	44
plant growth	44
human brain	44
seed extract	44
genes involved	44
brain barrier	44
mouse brain	44
environmental factors	44
large scale	44
genes encoding	44
paulownia tomentosa	44
binding properties	44
apc resistance	44
ankara university	44
dna polymerase	44
cells expressing	44
receptor antagonists	44
measured using	44
least one	44
pyramidal cells	44
cell division	43
binding activity	43
determine whether	43
gene encoding	43
dna methylation	43
activity schedules	43
innate immune	43
time course	43
experimental data	43
per day	43
cellular uptake	43
coiled coil	43
gnrh neurons	43
molecular level	43
molecular modeling	43
analyzed using	43
synthesized using	43
fat diet	43
blood coagulation	43
methanol extract	43
phage display	43
antiviral properties	43
normal cells	43
mg protein	43
aqueous extract	43
serum albumin	42
yoghurt sample	42
science institute	42
immune cells	42
inhibitory potency	42
brown algae	42
play important	42
membrane permeability	42
will discuss	42
glial cells	42
selectivity index	42
four different	42
mutant mice	42
pharmakologie und	42
heart disease	42
oxide synthase	42
cardiovascular diseases	42
molecular basis	42
statistical analysis	42
active peptides	42
gel filtration	42
genomic dna	42
diabetic patients	41
vitro antiviral	41
throughput screening	41
life sciences	41
azadirachta indica	41
kg body	41
small number	41
protein tyrosine	41
hippocampal slices	41
peptide chain	41
minimum inhibitory	41
induces apoptosis	41
anticancer agents	41
oxidative damage	41
induced oxidative	41
energy transfer	41
hydroxyl groups	41
inflammatory effects	41
human umbilical	41
plasmon resonance	41
neem oil	41
adhesion molecules	41
high degree	41
ketonic mannich	41
peptides derived	41
rat liver	41
umbilical vein	41
phase ii	41
amyloid fibrils	41
nmda receptors	41
cyclic peptide	41
ex vivo	41
surface plasmon	41
significant changes	41
broad range	40
differentially expressed	40
three times	40
three groups	40
enzyme inhibition	40
healthy volunteers	40
cancer therapy	40
bacterial growth	40
also increased	40
obtained using	40
potential anti	40
inhibition activity	40
target proteins	40
glycyrrhiza glabra	40
organic solvents	40
remains unclear	40
metabolic engineering	40
serum levels	40
results demonstrated	40
primary structure	40
growth rate	40
ec values	40
protein coupled	40
takes place	40
previously shown	40
peptide sequences	40
healthy controls	40
und toxikologie	40
chemical constituents	40
bond formation	39
cord injury	39
also demonstrated	39
free energy	39
reporter gene	39
glucose levels	39
essential role	39
exclusion chromatography	39
fluorescent protein	39
significantly inhibited	39
sulphated ps	39
structurally related	39
protease inhibitor	39
drug candidates	39
dentate gyrus	39
mitochondrial membrane	39
disulfide bridges	39
expression vector	39
potent activity	39
plasma levels	39
coronary artery	39
dose dependent	39
peptide sequence	39
autoimmune diseases	39
ca region	39
performance liquid	39
chain reaction	39
cell biology	39
acid composition	39
physicochemical properties	39
highly specific	39
hcv rna	39
natural sources	39
amine reagent	38
medical university	38
will present	38
expression profiles	38
based probes	38
metabolic stability	38
potential therapeutic	38
cordyceps militaris	38
rat hippocampal	38
signal peptide	38
light scattering	38
previously described	38
complex formation	38
bovine serum	38
lead compound	38
free amino	38
clinical trial	38
polymerase chain	38
resistant staphylococcus	38
protecting groups	38
helicobacter pylori	38
chemical ligation	38
aminope ptidase	38
active compound	38
i will	38
family members	38
enzymes involved	38
scientific research	38
assay using	38
aerial parts	38
apoptotic cell	38
olfactory bulb	38
will also	38
receptor agonist	38
opioid receptor	38
rhinovirus infection	38
schiff bases	38
showed higher	38
disulfide bonds	38
cells showed	38
may cause	38
osaka university	38
fusion proteins	38
intracellular ca	37
mtlr activity	37
marine compounds	37
carbonic anhydrase	37
increased significantly	37
studies demonstrated	37
adrenergic receptor	37
times higher	37
viral diseases	37
male wistar	37
structural studies	37
glutathione peroxidase	37
cells using	37
crude extracts	37
platelet count	37
rational design	37
oral bioavailability	37
trypanosoma brucei	37
min mg	37
anticoagulant activity	37
chain cleavage	37
findings indicate	37
antifungal agents	37
method using	37
neem cake	37
stress response	37
methyl group	37
signifi cantly	37
may affect	37
respiratory infections	37
arachidonic acid	37
much higher	37
exchange chromatography	37
cell type	37
aliphatic amines	37
outer membrane	37
ntm species	37
ace activity	36
terminal part	36
medical school	36
growth cone	36
research group	36
substantia nigra	36
vein endothelial	36
effi ciency	36
immune function	36
bacterial infections	36
human serum	36
cycle arrest	36
antimicrobial compounds	36
organic compounds	36
higher concentrations	36
catalytic domain	36
significant effect	36
starting point	36
size exclusion	36
inflammatory diseases	36
coupled receptor	36
metabolic syndrome	36
data obtained	36
trypanosomal activity	36
lead compounds	36
without affecting	36
normal human	36
double mannich	36
peptide fragments	36
ion exchange	36
time points	36
science foundation	36
delivery systems	36
glutamate receptor	35
fl ower	35
last decade	35
recent advances	35
carbon source	35
penetrating peptides	35
female rats	35
upper respiratory	35
protein binding	35
marine algae	35
data show	35
will provide	35
biological functions	35
degradation products	35
punicic acid	35
traditionally used	35
may represent	35
recently reported	35
infrared spectroscopy	35
heparan sulfate	35
cardiovascular disease	35
chemical properties	35
dopaminergic neurons	35
nmr spectra	35
recent study	35
biochemical parameters	35
secondary aliphatic	35
biological effects	35
selective inhibitors	35
mycolic acids	35
also tested	35
early stage	35
ring system	35
showed good	35
red blood	35
citric acid	35
living organisms	35
specific antibodies	35
positive correlation	35
carcinoma cells	35
cd cd	35
long term	35
stress conditions	34
confocal microscopy	34
obtained results	34
studies using	34
analysis using	34
bat activity	34
new insights	34
virtual screening	34
tertiary structure	34
studied using	34
mesenchymal stem	34
low activity	34
mononuclear cells	34
amide bond	34
culture conditions	34
synergistic effect	34
two distinct	34
pathogenic fungi	34
replacement therapy	34
moderate activity	34
hiv activity	34
brain development	34
health sciences	34
like receptor	34
food industry	34
basal ganglia	34
ethanolic extract	34
cell penetrating	34
plasminogen activator	34
sedentary behavior	34
sensory neurons	34
glutamate receptors	34
human colon	34
highly expressed	34
reaction mixture	34
growth hormone	34
melanoma cells	34
brain tissue	34
receptor activation	34
compounds isolated	34
coumarin nucleus	34
volatile oil	34
total antioxidant	33
growth factors	33
dependent protein	33
protein interaction	33
transmembrane domain	33
increased risk	33
fusarium oxysporum	33
physiological role	33
dorsal root	33
ray crystallography	33
antiviral compounds	33
structural characterization	33
specifi cally	33
years ago	33
ferulic acid	33
may result	33
chemical modification	33
vascular smooth	33
like proteins	33
protein degradation	33
dna gyrase	33
activity using	33
new therapeutic	33
compounds exhibited	33
fl uorescent	33
kyoto univ	33
acid residue	33
antioxidant status	33
kinetic parameters	33
signalling pathways	33
syncytial virus	33
results will	33
world health	33
probably due	33
elevated levels	33
mice showed	33
vero cells	33
cell apoptosis	33
methanol extracts	33
inflammatory responses	33
infected mice	33
dna replication	33
caffeic acid	33
life science	33
pomegranate peel	33
native chemical	33
vascular endothelial	33
respiratory syncytial	33
dawley rats	33
motor neurons	33
studies suggest	33
middle east	32
human diseases	32
tohoku univ	32
peptide analogues	32
venous thrombosis	32
expression patterns	32
lactate dehydrogenase	32
mosaic virus	32
control cells	32
chemical structures	32
analgesic activity	32
direct interaction	32
data demonstrate	32
catalytic site	32
environmental conditions	32
weight management	32
glycyrrhetinic acid	32
marine organisms	32
electrostatic interactions	32
two compounds	32
recombinant human	32
peptide library	32
diffi cult	32
binding assay	32
treated group	32
point mutations	32
early stages	32
concentration range	32
different mechanisms	32
acid production	32
resonance energy	32
topoisomerase i	32
adhesion molecule	32
weight gain	32
dna synthesis	32
alkaline phosphatase	32
increased expression	32
antiplasmodial activity	32
see scheme	32
experimental conditions	32
pharmacokinetic properties	32
lipid bilayers	32
pathological conditions	32
derived peptides	32
open reading	32
unnatural amino	32
different cell	32
quality control	32
bariatric surgery	32
sesquiterpene lactones	32
social media	32
expressing cells	32
gene transcription	32
examined whether	32
cells treated	32
botrytis cinerea	32
tissue factor	32
fruiting bodies	32
carbon atoms	31
pharmaceutical industry	31
pharmacological activity	31
particular interest	31
many different	31
compounds may	31
tohoku university	31
cell lysates	31
eukaryotic cells	31
kg bw	31
many studies	31
therapeutic target	31
using two	31
powerful tool	31
control mice	31
major components	31
protecting group	31
pharmaceutical sciences	31
tokyo metropolitan	31
also able	31
particle size	31
highly effective	31
chemical stability	31
extracts showed	31
human liver	31
terminal amino	31
health organization	31
double bond	31
chain length	31
least two	31
study revealed	31
old rats	31
anticancer drugs	31
nagoya university	31
physiological conditions	31
carcinoma cell	31
tissue engineering	31
projection neurons	31
ph values	31
quantitative analysis	31
using various	31
membrane fusion	31
active constituents	31
present results	31
control subjects	31
oil encapsulated	31
glucose level	31
increased levels	31
experiments showed	31
authors declare	31
phase i	31
expression pattern	31
tumor suppressor	31
tumour cells	31
juice consumption	31
better understand	31
enzymatic hydrolysis	30
fermentation process	30
recently developed	30
cancer stem	30
take place	30
vitro assays	30
well established	30
biological systems	30
physical distancing	30
nuclear magnetic	30
ca influx	30
phosphorylation sites	30
insulin secretion	30
peptide libraries	30
health problem	30
active sites	30
different stages	30
per week	30
green tea	30
total protein	30
cleavage site	30
bacterial bglu	30
therapeutic strategies	30
dimensional structure	30
new analogues	30
molecular target	30
antibiotic resistance	30
gastrointestinal tract	30
type mice	30
methyl ester	30
currently used	30
protein engineering	30
mammary gland	30
rna replication	30
cancer treatment	30
values ranging	30
long time	30
blood flow	30
ca pyramidal	30
agents synthesis	30
chronic inflammation	30
locomotor activity	30
strand breaks	30
ovarian cancer	30
cytoplasmic membrane	30
protein function	30
mrna level	30
promising results	30
clinical isolates	30
metabolic pathways	30
energy metabolism	30
fluorescence microscopy	30
structure activity	30
hiv infection	30
significant role	30
pivotal role	30
cysteine proteases	30
cholesterol side	30
possible role	30
prepared compounds	30
control groups	30
biological function	30
related genes	30
methanolic extract	30
decreased significantly	30
brain function	30
ethanol extract	30
red alga	29
proteolytic enzymes	29
herbal medicine	29
fl avonoids	29
higher levels	29
phosphate buffer	29
gene transfer	29
various types	29
investigate whether	29
viral dna	29
conformational analysis	29
neural activity	29
mycelial growth	29
new derivatives	29
medium containing	29
neurotrophic factor	29
low doses	29
binding studies	29
auditory cortex	29
dorsal horn	29
based approach	29
fluorescence intensity	29
chlorogenic acid	29
sexual activity	29
colon carcinoma	29
serum samples	29
pg ml	29
ros production	29
chain fatty	29
containing peptides	29
potent inhibitory	29
protective role	29
normal range	29
fl owers	29
therapeutic applications	29
dna sequences	29
hippocampal ca	29
high molecular	29
may help	29
sh domain	29
may serve	29
mesangial cells	29
binding motif	29
inhibitory concentrations	29
also studied	29
adult male	29
chemical structure	29
whole cell	29
endophytic fungus	29
structural information	29
information processing	29
high yield	29
kda protein	29
natural killer	29
two novel	29
develop new	29
years old	29
different doses	29
opioid receptors	29
provide new	28
antimicrobial effects	28
comet assay	28
oxygen transfer	28
organic acids	28
riken brain	28
ion channel	28
among others	28
docking study	28
prion protein	28
term potentiation	28
leydig cells	28
new method	28
neuronal death	28
enveloped viruses	28
much lower	28
low levels	28
mitochondrial dysfunction	28
health care	28
steady state	28
new zealand	28
data analysis	28
guinea pigs	28
protein aggregation	28
glucose tolerance	28
protein concentration	28
surface expression	28
investigated whether	28
linolenic acid	28
cellular functions	28
receptor subtypes	28
time spent	28
limited number	28
helical structure	28
functional properties	28
enzyme inhibitors	28
reading frame	28
liver tissue	28
also exhibited	28
gene therapy	28
adult rats	28
cultured rat	28
vitro study	28
human skin	28
transduction pathways	28
ray diffraction	28
metal ion	28
activity assay	28
two main	28
health benefits	28
acid bacteria	28
plasma glucose	28
healthy individuals	28
rna viruses	27
new anti	27
patients treated	27
novel compounds	27
clinical applications	27
neuronal differentiation	27
single cell	27
mouse models	27
future studies	27
data showed	27
protein complex	27
drug resistant	27
amino groups	27
fully understood	27
frontal cortex	27
liver injury	27
mental health	27
bean trypsin	27
great interest	27
gabaergic neurons	27
will allow	27
inflammatory mediators	27
nerve injury	27
physiological processes	27
highly sensitive	27
water extract	27
antimycobacterial agents	27
dendritic cells	27
different species	27
isolated compounds	27
neural network	27
confi rmed	27
inflammatory effect	27
high fat	27
culture media	27
peritoneal macrophages	27
titration calorimetry	27
high dose	27
intestinal bacteria	27
new york	27
compounds containing	27
kinase activity	27
previous work	27
cultured cells	27
mmpl inhibitors	27
receptor subtype	27
organic chemistry	27
three new	27
coupling reagents	27
increasing concentrations	27
disulfide bond	27
cells compared	27
still unknown	27
assessed using	27
evidence suggests	27
developing countries	27
acute myocardial	27
potential use	27
delivery system	27
trypsin inhibitory	27
fluorescent probe	27
dendritic spines	27
great potential	27
high selectivity	27
programmed cell	27
showed activity	27
kidney cells	27
amyloid formation	27
nervous systems	27
stranded dna	27
results provide	27
mass spectrometric	27
central role	27
physiological functions	27
tumour cell	27
using fmoc	27
also evaluated	27
sedentary behaviour	27
antiviral drug	27
working memory	27
like protein	27
ionic liquids	27
based compounds	27
new generation	26
model peptides	26
factor xa	26
ros generation	26
light chain	26
specific binding	26
antimicrobial agent	26
useful tool	26
clotting time	26
related proteins	26
like activity	26
morphological changes	26
cancer types	26
aqueous solutions	26
binding domains	26
good activity	26
high performance	26
gram negative	26
structural similarity	26
tissue culture	26
linoleic acid	26
transmembrane domains	26
diarrhea virus	26
rna binding	26
high affi	26
action potentials	26
several types	26
se rum	26
reference drugs	26
antioxidant potential	26
listeria monocytogenes	26
research groups	26
ribosomal proteins	26
body mass	26
highest value	26
hydrophobic interactions	26
therapeutic effects	26
extensively studied	26
treated animals	26
point mutation	26
specific inhibitors	26
gut microbiota	26
possible mechanism	26
controlled trial	26
research centre	26
showed moderate	26
crude extract	26
blood vessels	26
antiinflammatory activity	26
based assay	26
surface receptors	26
antiviral agent	26
transition state	26
also examined	26
thyroid hormone	26
dna strand	26
tof mass	26
high purity	26
antibacterial properties	26
studies indicate	26
receptive field	26
androgen receptor	26
cd spectroscopy	26
arabidopsis thaliana	26
glucose uptake	26
column chromatography	26
recently identified	26
acute phase	26
studies indicated	26
isothermal titration	26
inhibition zones	26
influenza viruses	26
also performed	26
steroidal saponins	26
raw material	26
binding pocket	26
plaque reduction	26
polyunsaturated fatty	26
leukemia cells	25
mg dl	25
rna synthesis	25
treated mice	25
specific manner	25
response element	25
aqueous media	25
test drug	25
expression system	25
gram positive	25
multidrug resistance	25
substrate binding	25
disc diffusion	25
human prostate	25
experiments revealed	25
albino rats	25
vitro evaluation	25
vivo activity	25
cultured human	25
potent antiviral	25
mechanism underlying	25
mammalian cell	25
blood plasma	25
patients suffering	25
cultured cordyceps	25
tract infections	25
machine learning	25
enzymatic activities	25
highly potent	25
four times	25
high doses	25
derivatives showed	25
inhibitory potential	25
endothelial growth	25
prothrombin time	25
cysteine residues	25
less toxic	25
next step	25
showed strong	25
low cytotoxicity	25
therapeutic agent	25
charged residues	25
medicinal properties	25
nitrogen atom	25
sulfated polysaccharides	25
university students	25
reduction assay	25
thrombus formation	25
cytokine production	25
proteins may	25
marine pharmacology	25
inhibitory action	25
also shown	25
phaseolus vulgaris	25
total number	25
yeast extract	25
mainly due	25
sleeping sickness	25
protein production	25
cow milk	25
also inhibited	25
class i	25
fold less	25
epigallocatechin gallate	25
binding assays	25
various biological	25
terminal sequence	25
mass spectrometer	25
activity may	25
different parts	25
still unclear	25
topoisomerase ii	25
cell activation	25
free conditions	25
potential antiviral	25
scanning electron	25
final concentration	25
gene regulation	25
terminal fragment	25
interacting protein	25
activity comparable	25
native peptide	25
activity evaluation	25
nmr studies	25
potential target	25
short peptides	25
translational modification	25
streptomyces sp	25
diabetic mice	24
two decades	24
potential role	24
substituted phenyl	24
dependent inhibition	24
promoter region	24
alzheimer disease	24
significant inhibition	24
glutamate release	24
proinflammatory cytokines	24
regression analysis	24
click chemistry	24
per se	24
hydrophobic interaction	24
two major	24
major component	24
transmitter release	24
building block	24
will describe	24
microwave irradiation	24
new type	24
commonly found	24
ser thr	24
group compared	24
chemically synthesized	24
like domain	24
mycolic acid	24
chalcone analogues	24
endophytic fungi	24
purkinje cell	24
several proteins	24
methanolic extracts	24
blood mononuclear	24
also reduced	24
new approach	24
positive charge	24
result suggests	24
relatively low	24
dna sequence	24
protein sequence	24
guinea pig	24
immunomodulatory activity	24
laser desorption	24
phenolic content	24
actin cytoskeleton	24
activity schedule	24
various diseases	24
green fluorescent	24
great importance	24
precursor protein	24
new drug	24
adult rat	24
north america	24
fourier transform	24
new antiviral	24
human cytomegalovirus	24
lung adenocarcinoma	24
mice treated	24
toxic effect	24
mdck cells	24
cells via	24
activity studies	24
ug ml	24
low concentration	24
million people	24
structural biology	24
rna molecules	24
scutellaria baicalensis	24
beta cells	24
host defense	24
ph range	24
different classes	24
chinese medicinal	24
solid state	24
ms analysis	24
neonatal rat	24
expression analysis	24
social isolation	24
model systems	24
bacterial cells	24
local community	24
functional analysis	24
key enzyme	24
increasing interest	24
lesser extent	24
oleic acid	24
remained unchanged	24
cysteine protease	24
mast cell	24
comparative study	24
mass index	24
plant extract	24
acid transport	24
surface area	24
mast cells	24
peptide backbone	24
give rise	24
rhizoctonia solani	24
exhibited significant	24
bl mice	24
insulin sensitivity	24
higher affinity	24
apoptotic cells	24
distilled water	23
glucuronic acid	23
shock proteins	23
research team	23
drug target	23
viral entry	23
female mice	23
neural activities	23
subcellular localization	23
structural elements	23
bactericidal activity	23
human neutrophils	23
negative control	23
lipid metabolism	23
significant correlation	23
inflammatory properties	23
completely abolished	23
microarray analysis	23
cacybp sip	23
virus particles	23
sequence similarity	23
molecular targets	23
help us	23
anticancer activities	23
increased activity	23
sodium alginates	23
polyacrylamide gel	23
willebrand factor	23
also detected	23
new series	23
fever virus	23
different chemical	23
triazole derivatives	23
complex i	23
cerebral ischemia	23
infections caused	23
fungal cell	23
high glucose	23
cell lung	23
glucuronidase inhibitors	23
transcriptional activation	23
thrombin generation	23
molecule inhibitors	23
proteasome system	23
drinking water	23
neuronal migration	23
derived neurotrophic	23
days post	23
survival rate	23
cleavage sites	23
sar studies	23
cdna library	23
catalytic efficiency	23
higher concentration	23
differential expression	23
disease caused	23
liver disease	23
functional role	23
median age	23
well understood	23
neuroprotective effects	23
genetic engineering	23
allow us	23
shed light	23
chronic hepatitis	23
calcium channels	23
significantly improved	23
bglu inhibitors	23
glucuronidase activity	23
fi brils	23
high pressure	23
financial support	23
water molecules	23
novel series	23
thromboplastin time	23
biological membranes	23
time point	23
tyrosine kinases	23
exhibited potent	23
kinase inhibitor	23
serine proteinase	23
electrical stimulation	23
viral proteins	23
ge healthcare	23
tourism industry	23
minimal inhibitory	23
crypt unit	23
fungal strains	23
tissue damage	23
angiotensin i	23
cells infected	23
well documented	23
highest activity	23
plasma ace	23
coagulation factors	23
model membrane	23
diffusion coefficient	23
direct contact	23
small amounts	23
site directed	22
factor receptor	22
using standard	22
vivo study	22
aspergillus flavus	22
stationary phase	22
food products	22
russian science	22
ns protease	22
rich source	22
also determined	22
promoter activity	22
mm tris	22
peptide derivatives	22
artifi cial	22
raw materials	22
helix bundle	22
silica gel	22
drug targets	22
selectivity towards	22
novel peptide	22
leading cause	22
active packaging	22
desorption ionization	22
acid side	22
defi ned	22
apoptotic effects	22
regulatory proteins	22
ethanol production	22
antioxidant enzymes	22
structure prediction	22
water solubility	22
glioma cells	22
protein sequences	22
transmission electron	22
like protease	22
study aimed	22
ml min	22
ubiquitin proteasome	22
high frequency	22
binding capacity	22
cardiac hypertrophy	22
well characterized	22
inflammatory activities	22
total cholesterol	22
calf thymus	22
heavy metals	22
fibril formation	22
human genome	22
different methods	22
brain tissues	22
riken bsi	22
matrix metalloproteinases	22
activity recognition	22
water maze	22
also suggest	22
cationic antimicrobial	22
relationship studies	22
associated protein	22
receptor agonists	22
specific protein	22
keio univ	22
various concentrations	22
induced platelet	22
salicylic acid	22
effi cacy	22
synthesis using	22
screen time	22
ionic strength	22
transforming growth	22
study also	22
novel class	22
negative correlation	22
platelet counts	22
hydrophobic core	22
mass transfer	22
functional roles	22
fear memory	22
transcriptional regulation	22
tourism activities	22
cultural tourism	22
different cancer	22
mic value	22
heavy chain	22
corylifolia extract	22
expression profile	22
lymph nodes	22
sitting time	22
chemical compounds	22
acid analysis	22
soluble fibrin	22
blood loss	22
peptide ligands	22
reaction conditions	22
dynamic light	22
microwave assisted	22
helical conformation	22
peel extract	22
ii diabetes	22
currently available	22
green alga	21
cell bodies	21
nanomolar range	21
recently shown	21
triphosphatase activity	21
computational methods	21
neuronal damage	21
nadph oxidase	21
transgenic mouse	21
growth cones	21
low affinity	21
different time	21
culture system	21
risk assessment	21
cells grown	21
antitumour activity	21
resistant bacteria	21
motor learning	21
university hospital	21
one hand	21
folk medicine	21
worth noting	21
containing two	21
plasmid dna	21
intestinal microbiota	21
high risk	21
older adults	21
might play	21
reference compound	21
translational modifications	21
two peptides	21
patients undergoing	21
relatively high	21
studies will	21
activity synthesis	21
young people	21
carotid artery	21
feline interferon	21
developmental stages	21
oxidant activity	21
low density	21
potentially useful	21
oxidative dna	21
paw edema	21
gene cluster	21
brown seaweed	21
mice lacking	21
viral envelope	21
blood cell	21
medical research	21
ecklonia stolonifera	21
structural diversity	21
vein thrombosis	21
per min	21
synthetic strategy	21
viral genome	21
phase method	21
fatty liver	21
research council	21
group ii	21
polyethylene glycol	21
signalling pathway	21
minor groove	21
basic research	21
activated receptor	21
therapeutic targets	21
microglial cells	21
fmoc tbu	21
multidrug resistant	21
platelet function	21
inducing apoptosis	21
virus infections	21
single molecule	21
tissue samples	21
lysine residues	21
highly variable	21
nagoya univ	21
structural basis	21
largely unknown	21
medical science	21
several different	21
ic mm	21
capillary electrophoresis	21
test compounds	21
natural amino	21
vesicular stomatitis	21
cell density	21
covalently linked	21
defense system	21
ray scattering	21
sequence homology	21
brain injury	21
domain swapping	21
cell signaling	21
much less	21
derivatives containing	21
yeast cells	21
cell activity	21
zoster virus	21
protein molecules	21
releasing hormone	21
clinical symptoms	21
sequence information	21
almost completely	21
iu ml	21
four groups	21
blood levels	21
using molecular	21
well plates	21
blood serum	21
pulmonary disease	21
creative commons	21
inclusion bodies	21
least partially	21
surround suppression	21
rich peptides	21
pomegranate fl	21
potent antioxidant	21
presentation will	21
protein structures	21
arginine residues	21
data collection	21
cell patch	21
pulmonary embolism	21
showed increased	21
phosphatase activity	21
corylifolia linn	21
heterologous expression	21
large numbers	20
activity toward	20
metropolitan institute	20
molecular interactions	20
urine samples	20
triazole ring	20
protein stability	20
bioactive metabolites	20
translation initiation	20
tyrosine phosphorylation	20
drug administration	20
charged amino	20
also play	20
stomatitis virus	20
flow cytometric	20
controlled release	20
mda levels	20
bleeding complications	20
structure elucidation	20
still remains	20
sciatic nerve	20
proteomic analysis	20
enzyme production	20
inhibition assay	20
atopic dermatitis	20
dub inhibitors	20
might contribute	20
novel approach	20
total phenolic	20
antibiotic activity	20
product formation	20
stranded rna	20
peptide derived	20
hiv reverse	20
different proteins	20
coagulation factor	20
structural protein	20
useful tools	20
molecular weights	20
experimental animals	20
water interface	20
food packaging	20
dependent kinase	20
glycopeptide antibiotics	20
cytotoxic agents	20
also called	20
ch ch	20
dna fragmentation	20
axon terminals	20
specific antibody	20
human intestinal	20
pharmacological effects	20
antibacterial effects	20
primary motor	20
integral membrane	20
brain research	20
low ph	20
medium composition	20
filamentous fungi	20
organic solvent	20
tract infection	20
disulfide bridge	20
coumarin scaffold	20
showed potent	20
total rna	20
mes test	20
control sample	20
study using	20
intracellular calcium	20
ray structure	20
significant change	20
salmonella typhimurium	20
fold lower	20
small cell	20
cell layer	20
brain activity	20
bacterial membrane	20
will show	20
treatment options	20
action potential	20
clinical signs	20
active components	20
renal failure	20
mean age	20
xenopus oocytes	20
fast food	20
binding partners	20
plants used	20
protein content	20
enzymatic degradation	20
carboxyl group	20
prepared using	20
er stress	20
resistance mechanisms	20
dpph radical	20
proline residues	20
reporter cell	20
cycle progression	20
ganoderma lucidum	20
reversed phase	20
md simulations	20
homologous recombination	20
sensitive dye	20
artery disease	20
mechanisms involved	20
showed better	20
skeletal muscles	20
bearing mice	20
force field	20
plaque formation	20
coronary heart	20
creative tourist	20
matrix metalloproteinase	20
recently discovered	20
i intron	20
water extracts	20
chinese herbal	20
pechmann condensation	20
supported lipid	20
candidate genes	20
human tumor	20
specific expression	20
first report	20
dna viruses	20
preliminary data	20
pcr analysis	20
frequently used	20
results also	20
fungal pathogens	20
study will	20
benzoic acid	20
binding mode	20
fi nal	20
fi ed	20
vitro model	20
fructus psoraleae	20
attractive target	20
type protein	20
expressed protein	20
high density	20
via inhibition	20
proteinase inhibitors	20
peptide chemistry	20
epidermal growth	20
clinical use	20
cellular proteins	20
plasmodial activity	20
cholera toxin	20
dioscorea species	20
highest antioxidant	20
higher plants	20
human amps	20
fluorescence spectroscopy	20
prenylated coumarins	20
human cell	20
herpes virus	20
aminomethyl function	20
high temperature	20
aromatic aldehydes	20
rna interference	20
human blood	20
physiological ph	20
cytotoxicity towards	20
vitro antibacterial	20
standard deviation	20
based assays	20
stimulatory effect	20
medical sciences	20
different molecular	20
state university	20
developed countries	20
steroid hormones	20
wide spectrum	20
therapeutic approach	20
one study	19
proteolytic degradation	19
transmembrane protein	19
epithelial cell	19
corona virus	19
phenolic hydroxyl	19
underlying mechanism	19
vitro antimicrobial	19
jak stat	19
hcv ns	19
surface antigen	19
vice versa	19
green fluorescence	19
purified using	19
studies suggested	19
target cell	19
phytopathogenic fungi	19
extract showed	19
within days	19
antimalarial drugs	19
xenopus laevis	19
ca channel	19
vivo anti	19
high content	19
type ca	19
neurons showed	19
glutathione reductase	19
rats treated	19
key enzymes	19
chronic obstructive	19
antidiabetic activity	19
many diseases	19
activity probes	19
therapeutic intervention	19
administered orally	19
different conditions	19
van der	19
cell differentiation	19
flow rate	19
disease virus	19
group showed	19
study suggests	19
thin layer	19
chronic diseases	19
elevated plus	19
antitumor activities	19
interacting proteins	19
less effective	19
gives rise	19
xanthine oxidase	19
different groups	19
single amino	19
low temperature	19
study investigated	19
medium supplemented	19
neutral ph	19
endophytic bacteria	19
total oxidant	19
high efficiency	19
table iii	19
study included	19
lipid rafts	19
volatile basil	19
spatial memory	19
using nmr	19
specific inhibitor	19
structural motifs	19
metal binding	19
provide evidence	19
urgent need	19
three major	19
heat stress	19
protein fragments	19
methyl groups	19
treated rats	19
incubation period	19
cationic amino	19
fi eld	19
liver microsomes	19
synaptic vesicles	19
lactobacillus plantarum	19
activity increased	19
antiviral therapy	19
control animals	19
human host	19
candida activity	19
axon guidance	19
inner membrane	19
diseases including	19
low abundance	19
disease states	19
aminoisobutyric acid	19
inhibit viral	19
gene products	19
proteinase inhibitor	19
processes including	19
glucose metabolism	19
financially supported	19
small peptides	19
model membranes	19
three dimensional	19
leaf extracts	19
profi le	19
chemotherapeutic agents	19
side reactions	19
sars coronavirus	19
detailed study	19
negative effects	19
several factors	19
optical imaging	19
colony formation	19
novel mannich	19
catalytic residues	19
human igg	19
fos expression	19
preclinical studies	19
cell extracts	19
pyrrole derivatives	19
conventional antibiotics	19
first study	19
receptor subunits	19
sh domains	19
ca binding	19
coupling reaction	19
shelf life	19
good agreement	19
wistar albino	19
antiviral potential	19
peptide substrates	19
carbon dioxide	19
various cell	19
nose syndrome	19
thiobarbituric acid	19
propidium iodide	19
biotechnology institute	19
alkyl chain	19
synaptic inputs	19
antioxidant effect	19
water soluble	19
fluorescent probes	19
gold nanoparticles	19
binding affinities	19
cytopathic effect	19
transport activity	19
results support	19
mice infected	19
virus entry	19
homology model	19
toxicity studies	19
matrix proteins	19
mental retardation	19
time consuming	19
membrane fluidity	19
inflammatory processes	19
oxidant status	19
cgmp signaling	19
synthesized peptides	19
success rate	19
clinical development	19
linear peptide	19
comparative analysis	19
mediated via	19
cells without	19
like growth	19
leukemia cell	19
double mutant	19
volatile organic	19
lung carcinoma	19
aromatic plants	19
bladder cancer	19
granule cell	19
chemical modifications	19
study shows	19
structural requirements	19
coli bglu	19
abundance scores	19
prolyl oligopeptidase	18
presynaptic terminals	18
human embryonic	18
reaction time	18
clamp recordings	18
antioxidant effects	18
schwann cells	18
cytotoxicity studies	18
fruiting body	18
sodium channel	18
ca signals	18
per cent	18
antithrombin iii	18
visual information	18
double bonds	18
cinnamic acid	18
low dose	18
dairy products	18
septic shock	18
promising candidates	18
acute toxicity	18
cell carcinoma	18
rats fed	18
nitro group	18
thrombin inhibitors	18
strand rna	18
showed inhibitory	18
lower compared	18
contains two	18
carcinogenic cells	18
cells resulted	18
inflammatory drugs	18
japan science	18
showed similar	18
also present	18
large amounts	18
ischemia reperfusion	18
disordered proteins	18
metabolic processes	18
dopamine receptor	18
one patient	18
strong inhibitory	18
initiation factor	18
postnatal day	18
activity data	18
increasing evidence	18
low temperatures	18
structural properties	18
ca channels	18
photosystem ii	18
sodium alginate	18
polypeptide chain	18
chromone derivatives	18
clinical application	18
layer chromatography	18
early diagnosis	18
well tolerated	18
assay showed	18
dominant negative	18
hplc analysis	18
sesquiterpene lactone	18
novel mechanism	18
dilution method	18
proliferative activity	18
three days	18
oxidative phosphorylation	18
conducted using	18
well suited	18
time dependent	18
study group	18
experimental studies	18
carboxamide derivatives	18
ml concentration	18
coding region	18
dry weight	18
randomized controlled	18
visual stimuli	18
gene product	18
neutral red	18
many cases	18
antiprotozoal activity	18
potent antibacterial	18
ethylene glycol	18
peptide conjugates	18
marked increase	18
described previously	18
alternative splicing	18
compound exhibited	18
triple helix	18
pure compounds	18
biosynthetic pathway	18
optical density	18
chromatographic separation	18
age groups	18
hemolytic activity	18
retention time	18
human subjects	18
may act	18
routine activity	18
atomic force	18
carbon sources	18
strong anti	18
aqueous extracts	18
two classes	18
novel anti	18
molecular structure	18
adenylyl cyclase	18
final product	18
brain tumors	18
important step	18
immunomodulatory properties	18
data support	18