bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
amino acid	1057
amino acids	1022
sialic acid	788
sialic acids	397
fatty acids	380
mass spectrometry	375
cancer cells	292
neu gc	239
cell lines	229
fatty acid	218
pomegranate juice	218
glutamic acid	197
acid residues	180
neu ac	176
escherichia coli	176
biological activity	175
antimicrobial peptides	173
gallic acid	172
solid phase	166
lactic acid	161
influenza virus	156
tannic acid	150
acetic acid	150
nucleic acid	149
breast cancer	146
punica granatum	144
cell surface	143
antimicrobial activity	140
plasma membrane	139
gene expression	138
present study	135
ellagic acid	133
binding sites	132
signi fi	132
peptide synthesis	131
side chain	128
molecular weight	120
important role	118
cancer cell	113
prostate cancer	110
fish oil	109
hairy roots	109
nucleic acids	109
immune response	109
binding site	106
antibacterial activity	104
nitric oxide	104
inhibitory activity	103
affi nity	101
cell line	101
cell proliferation	100
nervous system	99
mg kg	97
secondary structure	96
immune system	96
cell membrane	96
antioxidant activity	96
laser desorption	94
side chains	94
chlorogenic acid	94
active site	91
cell death	89
oxidative stress	87
ms ms	86
results suggest	85
antiviral activity	85
tumor cells	84
desorption ionization	83
citric acid	83
caffeic acid	82
epithelial cells	82
growth factor	82
wide range	81
staphylococcus aureus	80
pomegranate fruit	79
drug delivery	79
phase peptide	79
building blocks	79
acid sequence	79
endothelial cells	77
secondary metabolites	76
modifi ed	76
blood pressure	76
negative bacteria	75
liquid chromatography	74
virus infection	73
fi rst	73
click chemistry	72
phenolic compounds	72
hairy root	72
fi cantly	71
wild type	71
clinical trials	71
two different	71
cellular uptake	71
tof ms	70
antimicrobial peptide	70
acid binding	69
phenolic acids	69
inhibitory effect	69
biologically active	69
cell wall	69
central nervous	68
mass spectrometric	67
cord uid	67
organic acids	67
high affinity	67
chemical synthesis	67
doc id	67
body weight	66
results showed	66
cell adhesion	66
pr virus	66
protein synthesis	66
phase synthesis	65
skeletal muscle	64
tca cycle	64
cell growth	64
seed oil	64
mg ml	64
mammalian cells	63
acid production	63
assisted laser	63
large number	63
type i	62
widely used	62
identifi ed	62
results indicate	61
saccharomyces cerevisiae	60
acid derivatives	60
natural products	60
dependent manner	60
protein kinase	60
carboxylic acid	60
fl uorescence	60
acetylated sialic	60
dicaffeoylquinic acid	59
negatively charged	59
molecular dynamics	59
arachidonic acid	59
small molecules	59
leucine aminopeptidase	58
metal ions	58
polyalthic acid	58
effi cient	58
naturally occurring	57
glutamic acids	57
acid residue	57
signifi cant	57
fi cant	57
cell types	56
pomegranate extract	56
nmr spectroscopy	56
spinal cord	56
immune responses	56
may also	56
host cell	56
signal transduction	56
biological activities	55
animal models	55
red wine	55
necrosis factor	55
linked sialic	55
side effects	54
cancer therapy	54
acid composition	54
synthetic peptides	54
cyclic peptides	54
penetrating peptides	54
rheumatoid arthritis	53
molecular mass	53
results show	53
galla chinensis	53
binding domain	53
purifi cation	52
fruit extract	52
polyunsaturated fatty	52
gel electrophoresis	52
carbon source	52
lung cancer	52
different types	51
modifi cation	51
drug discovery	51
human serum	51
tumor necrosis	51
present work	51
binding protein	51
acetylneuraminic acid	50
cell membranes	50
binding proteins	50
root cultures	50
pomegranate seed	50
recent years	50
gum arabic	50
structural characterization	50
purifi ed	50
acid metabolism	49
activity relationship	48
aspartic acid	48
systematic review	48
infected mice	48
enzymatic activity	48
cell cultures	48
rhus chinensis	48
reactive oxygen	48
infl uence	48
tof tof	47
also known	47
oral administration	47
type ii	47
enzymatic hydrolysis	47
monoclonal antibodies	47
solid support	47
hydrochloric acid	47
specifi city	47
results obtained	47
peptides containing	47
studies showed	47
enzyme activity	46
alcohol consumption	46
acid ceramidase	46
lipid peroxidation	46
previous studies	46
positive bacteria	46
metabolic acidosis	46
cell cycle	46
protein expression	46
insulin resistance	46
room temperature	46
chemical engineering	46
angiotensin ii	45
ionization mass	45
malic acid	45
biological properties	45
crystal structure	45
closely related	45
substrate specificity	44
molecular biology	44
structural analysis	44
high resolution	44
methionine aminopeptidase	44
tandem mass	44
well known	44
free amino	44
highly conserved	43
synthetic peptide	43
cell culture	43
platelet aggregation	43
acid sequences	43
glycan binding	43
dna binding	43
target protein	43
recent studies	43
innate immune	43
also found	43
amino group	43
protein sequence	42
herpes simplex	42
chain fatty	42
three different	42
human health	42
polysialic acid	42
metabolic engineering	42
stem cells	42
aspergillus niger	42
inflammatory cytokines	42
high levels	42
circular dichroism	41
protein interactions	41
molecular mechanisms	41
pseudomonas aeruginosa	41
peptide chain	41
commercially available	41
broad spectrum	41
acid glycan	41
converting enzyme	41
cancer patients	41
medicinal plants	41
recombinant proteins	40
rat liver	40
linolenic acid	40
auf die	40
adipose tissue	40
identifi cation	40
performance liquid	40
oxygen species	40
binding affinity	40
palmitic acid	40
cell penetrating	40
sugar binding	39
therapeutic agents	39
modifi cations	39
monoclonal antibody	39
ms analysis	39
control group	39
ng ml	39
rat brain	38
wide variety	38
metabolic pathways	38
receptor binding	38
first step	38
commonly used	38
wine consumption	38
terminal region	38
gastrointestinal tract	37
functional groups	37
small intestine	37
delivery systems	37
sequence analysis	37
helicobacter pylori	37
sodium bicarbonate	37
cyclic peptide	37
signifi cantly	37
infected cells	37
serum albumin	37
acute respiratory	37
colon cancer	37
type diabetes	37
active peptides	37
amide bond	37
fold higher	37
food intake	37
peptide sequences	37
endoplasmic reticulum	37
betulinic acid	37
glycolylneuraminic acid	36
negative ion	36
peptide bond	36
melanoma cells	36
phenolic acid	36
fermentation process	36
recombinant protein	36
human brain	36
parenteral nutrition	36
methyl ester	36
binding activity	36
chemical structure	36
drug design	36
key role	36
effi ciency	36
acetyl groups	36
technical university	35
mouse model	35
transcription factors	35
punicic acid	35
target cells	35
spike protein	35
cystic fibrosis	35
linoleic acid	35
simplex virus	35
growth rate	35
metal ion	35
transcription factor	35
positively charged	35
affinity chromatography	35
ascorbic acid	35
apn cd	35
flow cytometry	35
tof mass	35
inflammatory response	35
coumaric acid	35
fl ower	35
bacillus subtilis	35
performed using	35
tumor growth	34
ic values	34
essential amino	34
antioxidant capacity	34
immune cells	34
electron microscopy	34
living cells	34
vitro studies	34
previously reported	34
aqueous solution	34
critical role	34
blood glucose	34
takes place	34
human cells	33
protecting groups	33
hydrogen bonding	33
pathogenic bacteria	33
gold nanoparticles	33
pomegranate peel	33
hydrogen bond	33
specifi cally	33
peptide design	33
palmitoylated proteins	33
peptide sequence	33
wistar rats	33
influenza viruses	33
serum levels	33
coiled coil	33
brain barrier	33
experimental data	33
tumor cell	33
peptide analogues	33
mouse brain	32
cryptochlorogenic acid	32
diabetes mellitus	32
ion mode	32
genes encoding	32
rational design	32
plasmodium falciparum	32
bioactive peptides	32
peptides derived	32
large scale	32
significantly increased	32
muscle mass	32
chemical ligation	32
growth hormone	32
conformational analysis	32
autoimmune diseases	32
human breast	32
dietary protein	32
membrane proteins	32
ganglioside gm	31
golgi apparatus	31
binding properties	31
energy metabolism	31
large amounts	31
immune function	31
acid transport	31
inhibitory effects	31
extracellular matrix	31
plasma amino	31
antimicrobial properties	31
nuclear factor	31
analysis revealed	31
bile acids	31
st gal	31
primary structure	31
juice consumption	31
activity relationships	31
proteins involved	31
necrotizing enterocolitis	31
also used	30
small molecule	30
much higher	30
mononuclear cells	30
blood cells	30
glycosylation sites	30
vivo studies	30
metabolic stability	30
synthesis using	30
endothelial cell	30
heart disease	30
multiple sclerosis	30
data suggest	30
surface area	30
free sialic	30
fl uorescent	30
high throughput	30
red blood	30
fusion protein	30
acid concentration	30
peptide fragments	29
physiological conditions	29
din en	29
catalytic activity	29
carbon dioxide	29
deficient mice	29
rats fed	29
new class	29
metabolic syndrome	29
peptide backbone	29
high degree	29
residues tof	29
clinical studies	29
building block	29
sialylated glycans	29
activator protein	29
newly synthesized	29
low molecular	29
helical structure	29
adhesion molecules	29
host cells	29
fl avonoids	29
diffi cult	29
surface plasmon	29
mrna expression	29
fl owers	29
mycophenolic acid	29
innate immunity	28
hydroxyl group	28
major role	28
acid content	28
oxygen transfer	28
bone marrow	28
widely distributed	28
protein palmitoylation	28
bacterial growth	28
molecular basis	28
protective effect	28
bond formation	28
secondary structures	28
linked glycans	28
native chemical	28
antioxidant properties	28
heparan sulfate	28
cultured cells	28
heat shock	28
ion channels	28
layer chromatography	28
sambucus formosananakai	28
eicosapentaenoic acid	28
induced apoptosis	28
significant increase	28
quantitative analysis	27
recombinant human	27
gene therapy	27
medium containing	27
fiber die	27
plasmon resonance	27
using fmoc	27
virus type	27
yeast extract	27
bioactive compounds	27
mass spectrometer	27
model peptides	27
terminal amino	27
also observed	27
directed mutagenesis	27
confi rmed	27
significantly decreased	27
infectious diseases	27
density lipoprotein	27
active sites	27
highly sensitive	27
ankara university	27
crucial role	27
first time	27
antifungal activity	27
blot analysis	27
protein sequences	27
dendritic cells	27
ethanol extract	27
peptide library	26
therapeutic potential	26
phytochemical constituents	26
human body	26
ern hrung	26
disulfide bridges	26
human igg	26
small amounts	26
antimicrobial agents	26
peptide ligands	26
chemical properties	26
potent inhibitors	26
results suggested	26
anticancer drugs	26
terminal part	26
may contribute	26
bovine serum	26
coupling reagents	26
glycan structures	26
physicochemical properties	26
colorectal cancer	26
natural amino	26
antimicrobial activities	26
biological processes	26
magnetic resonance	26
factors affecting	26
related compounds	26
ic value	26
virtual screening	26
critically ill	26
biological functions	26
carboxylic acids	26
new method	26
high affi	26
short peptides	26
animal model	25
may lead	25
cell type	25
conformational changes	25
potential therapeutic	25
culture medium	25
phage display	25
salmonella typhimurium	25
neurodegenerative diseases	25
null mice	25
base balance	25
glucose metabolism	25
may play	25
growth inhibition	25
hydroxyl groups	25
weight loss	25
taken together	25
normal human	25
vascular endothelial	25
plant species	25
membrane protein	25
signaling pathways	25
mechanical properties	25
free radicals	25
free radical	25
terminal domain	25
blood vessels	25
carboxyl group	25
structural features	25
molecular recognition	25
sh domain	25
based therapeutics	25
two groups	25
preliminary results	25
nmda receptor	25
containing peptides	25
fatty acyl	25
enzymes involved	25
penetrating peptide	25
exchange chromatography	25
flos lonicerae	25
high yield	25
native peptide	25
another study	25
protein folding	25
cell receptor	25
cancer treatment	24
years ago	24
open reading	24
low concentrations	24
gene encoding	24
least two	24
transgenic mice	24
total synthesis	24
drug resistance	24
clinical trial	24
human milk	24
signal peptide	24
peptide derivatives	24
disulfide bonds	24
therapeutic target	24
cognitive decline	24
also showed	24
carbonic anhydrase	24
structural determination	24
previously described	24
peripheral blood	24
high concentrations	24
immunodeficiency virus	24
unnatural amino	24
two types	24
acid bacteria	24
last years	24
results indicated	24
health benefits	24
genes involved	24
rich peptides	24
significantly reduced	24
opioid receptor	24
candida albicans	24
genomic dna	23
boronic acid	23
will also	23
low levels	23
peptide bonds	23
neochlorogenic acid	23
highly specific	23
aqueous solutions	23
enveloped viruses	23
hydrogen peroxide	23
investigated using	23
new analogues	23
cinnamic acid	23
animal viruses	23
receptor antagonist	23
dynamics simulations	23
hydrogen bonds	23
neuraminic acid	23
fi brils	23
amino groups	23
method using	23
protecting group	23
oic acid	23
protein structure	23
analysis using	23
studies revealed	23
using different	23
anticancer activity	23
opioid receptors	23
highly potent	23
ganglioside biosynthesis	23
calcium hydroxide	23
phase method	23
acid constituents	23
studies using	23
ethanol production	23
culture conditions	23
peptide nucleic	23
stationary phase	23
ang ii	23
smooth muscle	23
highly selective	23
estrogen receptor	23
natural sources	23
cardiovascular disease	23
biological evaluation	22
enzyme inhibitors	22
formic acid	22
lactic acidosis	22
delivery system	22
cell viability	22
times higher	22
commonly found	22
intrinsically disordered	22
several different	22
red wines	22
food industry	22
glutamate receptors	22
peel extract	22
human plasma	22
several studies	22
high molecular	22
tyrosine kinase	22
effi cacy	22
bei der	22
artifi cial	22
oxide synthase	22
physiological ph	22
bacterial cell	22
defi ned	22
proteomic analysis	22
bacterial species	22
electrospray ionization	22
ca i	22
pharmaceutical industry	22
plant extracts	22
acid concentrations	22
high level	22
superoxide dismutase	22
peptide libraries	22
fusion proteins	22
cell lung	22
apn inhibitors	22
plaque formation	22
wheat straw	22
lipid bilayer	22
respiratory syndrome	22
st sia	22
secondary metabolite	22
synthesized using	22
human skin	22
outer membrane	22
resistant staphylococcus	22
see section	22
target proteins	22
ferulic acid	22
potent inhibitor	22
negative charge	21
steric block	21
fold increase	21
pomegranate fl	21
oleic acid	21
significant effect	21
transition state	21
spike glycoprotein	21
present paper	21
drug development	21
like receptor	21
western blot	21
sample preparation	21
recent study	21
thin layer	21
acid load	21
recently reported	21
complete reduction	21
interaction chromatography	21
cancer cachexia	21
determine whether	21
molecular weights	21
functional analysis	21
polymalic acid	21
data indicate	21
cell division	21
activity towards	21
allowed us	21
determined using	21
helical conformation	21
peptide conjugates	21
structural information	21
brain development	21
fmoc tbu	21
rat plasma	21
plasmid dna	21
neuronal cells	21
solid state	21
human genome	21
biosynthetic pathway	21
gram negative	21
radical scavenging	21
middle east	21
structural studies	21
beneficial effects	21
nmr spectra	21
early stages	21
diabetic rats	21
pichia pastoris	21
wound healing	21
dna damage	21
clinical outcomes	21
ill patients	21
ray diffraction	21
gene delivery	21
gastric cancer	21
benzoic acid	21
human immunodeficiency	21
acid side	21
binding capacity	21
charged residues	20
eukaryotic cells	20
translational modifications	20
pulmonary diseases	20
ovarian cancer	20
also investigated	20
enzymatic degradation	20
mrna levels	20
results will	20
reading frame	20
successfully applied	20
prion protein	20
terminal fragment	20
medium composition	20
high performance	20
tertiary structure	20
molecular species	20
cell differentiation	20
polyphenolic compounds	20
water molecules	20
disulfide bond	20
chinese hamster	20
drug target	20
based approach	20
disease virus	20
united states	20
synthesized peptides	20
control mice	20
plant growth	20
molecular mechanism	20
anticancer drug	20
chemical stability	20
tumor suppressor	20
reporter gene	20
two main	20
green tea	20
coupled receptors	20
drug candidates	20
glucose uptake	20
gm activator	20
cultured human	20
kg body	20
will present	20
hela cells	20
respiratory distress	20
crystal structures	20
molecular docking	20
human colon	20
essential oils	20
protein design	20
inflammatory responses	20
cell epitopes	20
fi ed	20
also play	20
aromatic amino	20
unsaturated fatty	20
adhesion molecule	20
disulfide bridge	20
chain length	20
enzymatic synthesis	20
bacterial strains	20
capillary electrophoresis	20
human melanoma	20
structure activity	19
serine protease	19
renal tubular	19
essential role	19
lung injury	19
viral proteins	19
soybean oil	19
ion exchange	19
induces apoptosis	19
dimensional structure	19
chemical composition	19
intensive care	19
insulin sensitivity	19
degrading enzymes	19
ph values	19
camphoric acid	19
calcium carbonate	19
high temperature	19
secondary metabolism	19
older people	19
glucose levels	19
muscle cells	19
disordered proteins	19
rna viruses	19
model systems	19
dna sequences	19
two peptides	19
traditional chinese	19
recent advances	19
product formation	19
hamster ovary	19
mg gfw	19
interfering rna	19
intestinal tract	19
gene silencing	19
cysteine residues	19
serine proteases	19
propionic acid	19
cytokine production	19
ethyl acetate	19
acid glycans	19
positive ion	19
nmda receptors	19
model system	19
hydrophobic interaction	19
free fatty	19
human diseases	19
complex formation	19
expression levels	19
intestinal mucosa	19
obtained using	19
nuclear magnetic	19
broad range	19
cell migration	19
cell surfaces	19
environmental conditions	19
class i	19
arabidopsis thaliana	19
data sets	19
research centre	19
possible role	19
fi eld	19
potent anti	19
previous study	19
particle size	19
antibacterial properties	19
electrostatic interactions	19
intrinsic disorder	19
avian influenza	19
ligand binding	19
hepatocellular carcinoma	19
full length	19
chemical structures	19
fi nal	19
flight mass	19
evidence suggests	19
catalytic domain	19
cd spectroscopy	19
maldi mass	19
endothelial growth	19
thermal stability	19
two distinct	19
gas chromatography	19
cell survival	19
showed high	19
translational modification	19
septic shock	19
membrane fusion	19
insulin secretion	18
body composition	18
model peptide	18
acidic ph	18
ganglioside gd	18
ser thr	18
bile acid	18
umbilical vein	18
van der	18
plasma glucose	18
gram positive	18
tof synthesis	18
hyaluronic acid	18
terminal sialic	18
activated protein	18
kaurenoic acid	18
cmah gene	18
significant differences	18
gene products	18
various types	18
spectrometric analysis	18
computational methods	18
natural killer	18
acdase activity	18
throughput screening	18
acid inhibits	18
carcinoma cells	18
cho cells	18
protein interaction	18
adenylate cyclase	18
blood plasma	18
high content	18
low ph	18
distress syndrome	18
streptococcus pneumoniae	18
human diet	18
com scientificreports	18
insulin signaling	18
cells using	18
organic acid	18
last decade	18
may occur	18
nitrogen sources	18
antimicrobial effects	18
retention time	18
triple helix	18
important roles	18
protein levels	18
life sciences	18
cell apoptosis	18
peritoneal macrophages	18
phase ii	18
binding studies	18
cell epitope	18
enteral nutrition	18
protein kinases	18
reductive amination	18
protein production	18
specific activity	18
viral infection	18
kda protein	18
powerful tool	18
different concentrations	18
blood coagulation	18
natural product	18
different cell	18
quantum dots	18
growth factors	18
bacterial infections	18
diabetic patients	18
flow rate	18
drug administration	18
may provide	18
gel filtration	18
current study	18
expression vector	18
hepg cells	18
may result	18
acute lung	18
enzyme production	18
group ii	18
western blotting	18
may cause	18
cytotoxic activity	18
acid analysis	18
fermented juice	18
polypeptide chain	18
biological function	18
natural compounds	18
peptide chemistry	18
human prostate	18
mycobacterium tuberculosis	18
rich protein	18
fluorescence microscopy	18
related proteins	18
lipid metabolism	18
useful tools	17
tissue engineering	17
glucuronic acid	17
peptide derived	17
cell signaling	17
organic solvents	17
receptor antagonists	17
per se	17
column chromatography	17
small peptides	17
four different	17
great potential	17
infl ammatory	17
authors declare	17
studied using	17
arginine residues	17
secreted phospholipase	17
bestimmung der	17
surface receptors	17
scavenging activity	17
hplc analysis	17
national institute	17
monte carlo	17
potent antioxidant	17
medicinal chemistry	17
cellular membranes	17
data obtained	17
carbon sources	17
respiratory tract	17
binding affi	17
protein binding	17
small interfering	17
similar results	17
linked glycosylation	17
recently developed	17
pyruvate dehydrogenase	17
brain gangliosides	17
acid peptide	17
active compounds	17
high purity	17
conformational change	17
pharmacological activity	17
inflammatory mediators	17
organic chemistry	17
small number	17
relatively high	17
expression level	17
random coil	17
per day	17
poorly understood	17
promising results	17
severe acute	17
rna interference	17
chemical groups	17
virus attachment	17
pharmacological properties	17
factor receptor	17
also able	17
body fat	17
biological effects	17
acid oxidation	17
limited number	17
selective inhibitors	17
group i	17
gene transcription	17
short peptide	17
therapeutic applications	17
agrobacterium rhizogenes	17
antiproliferative activity	17
intracellular trafficking	17
brain tissue	17
batch phase	17
stranded rna	17
cationic amino	17
derived peptides	17
sea urchin	17
maldi ms	17
intracellular delivery	17
analysis showed	17
steady state	17
phosphate buffer	17
low doses	17
bile salts	17
great interest	17
kidney disease	17
hydrophobic interactions	17
great apes	17
programmed cell	17
cells via	17
serum samples	17
epithelial cell	17
extract inhibited	17
highly expressed	17
least one	17
two new	17
mammary gland	17
sequence similarity	17
research group	17
sole carbon	17
sirna delivery	17
inflammatory cells	16
controlled trial	16
glycan chains	16
endosomal escape	16
transmembrane protein	16
nutrition nr	16
high pressure	16
binding motif	16
lipid rafts	16
secretory phospholipase	16
chondroitin sulfate	16
acid hydrolysis	16
much less	16
public health	16
dna sequence	16
ordered proteins	16
central role	16
glycan analysis	16
nutritional status	16
high activity	16
muscular dystrophy	16
inflammatory diseases	16
silica gel	16
intestinal bacteria	16
ph range	16
alkaline ceramidase	16
immunomodulatory properties	16
linear peptide	16
membrane permeability	16
glucose level	16
plasma levels	16
acetyl group	16
metabolic pathway	16
immunomodulatory activity	16
tumor targeting	16
mass transfer	16
tissue sections	16
base theories	16
nmr studies	16
early stage	16
aqueous extract	16
formosananakai extract	16
gm gangliosidosis	16
blood mononuclear	16
creative commons	16
signal sequence	16
structural units	16
shock proteins	16
ex vivo	16
time point	16
expressed protein	16
sambucus nigra	16
cancer development	16
reverse transcriptase	16
fatty acylation	16
proteolytic activity	16
new approach	16
fl ammation	16
hydrophobic residues	16
sequence information	16
fat diet	16
dissolved oxygen	16
studies demonstrated	16
much lower	16
mast cells	16
vein endothelial	16
chronic kidney	16
receptor agonist	16
structurally related	16
light scattering	16
ionic liquid	16
also demonstrated	16
dry weight	16
sequence homology	16
human coronavirus	16
antibacterial activities	16
structural basis	16
nutritive value	16
gastric mucosa	16
guinea pigs	16
auf den	16
based method	16
profi le	16
splice correction	16
will describe	16
protease activity	16
conformational properties	16
two novel	16
antisense oligonucleotides	16
reversed phase	16
divalent cations	16
microwave assisted	16
conformational studies	16
structural changes	16
ion mobility	16
end products	16
signaling pathway	16
will allow	16
net charge	16
may represent	16
chromatographic separation	16
virus yield	16
neuronal cell	16
coronary heart	15
biological samples	15
relatively low	15
network structure	15
chain reaction	15
single molecule	15
energy transfer	15
anticancer effects	15
will provide	15
stem cell	15
different stages	15
oleanolic acid	15
viral rna	15
acid conjugates	15
olive oil	15
sinapinic acid	15
knockout mice	15
rnase iii	15
cell invasion	15
brain regions	15
viral genome	15
protein concentration	15
egg yolk	15
salivary glands	15
replacement therapy	15
cell monolayer	15
binding peptides	15
dna replication	15
significantly lower	15
novel peptide	15
different methods	15
binding domains	15
carbon atoms	15
mucosal surfaces	15
situ hybridization	15
gives rise	15
molecular modeling	15
proteinogenic amino	15
experimental conditions	15
compounds may	15
higher concentrations	15
myocardial infarction	15
trypsin inhibitor	15
three types	15
better understanding	15
plasma samples	15
genetic engineering	15
energy expenditure	15
phase extraction	15
tat peptide	15
enzyme activities	15
aroc values	15
containing two	15
wine phenolics	15
even though	15
gene cluster	15
pharmacological activities	15
pathological conditions	15
free energy	15
reaction mixture	15
single cell	15
protein coupled	15
dilution rate	15
filamentous fungi	15
beitrag zur	15
plant cell	15
alternative splicing	15
cell function	15
molecular cloning	15
two strains	15
methyl esters	15
cysteine residue	15
differential expression	15
polyacrylamide gel	15
cell density	15
key enzyme	15
low micromolar	15
aminopeptidase inhibitors	15
dental caries	15
structural diversity	15
significant role	15
different conditions	15
peptide binding	15
degradation products	15
highly efficient	15
different species	15
coupling reaction	15
acid levels	15
structural data	15
using various	15
point mutations	15
tryptic peptides	15
amyloid fibrils	15
dietary supplementation	15
chemically synthesized	15
protease inhibitors	15
blood flow	15
ring opening	15
nanomolar range	15
human cancer	15
particular interest	15
dairy products	15
protein molecules	15
fi cient	15
assay using	15
transmembrane domain	15
internal standard	15
male rats	15
polymerase chain	15
metabolic flux	15
chain amino	15
mammalian cell	15
double bond	15
three major	15
comparative study	15
three dimensional	15
well established	15
biomedical applications	15
effi ciently	15
pomegranate polyphenols	15
older adults	15
cycle arrest	15
mouse models	15
docosahexaenoic acid	15
mass spectra	15
medicinal plant	15
angiotensin converting	15
various biological	15
new drugs	15
magnetic nanoparticles	14
protein turnover	14
human umbilical	14
aminobutyric acid	14
clinical use	14
cantly inhibited	14
ms method	14
significant difference	14
polyethylene glycol	14
chronic diseases	14
fl ow	14
confi guration	14
calf thymus	14
pancreatic cancer	14
proteolytic degradation	14
various diseases	14
insect cells	14
different forms	14
acid compositions	14
antitumor activity	14
risk factors	14
potential application	14
studies will	14
positive charge	14
photodynamic therapy	14
proteolytic stability	14
aqueous media	14
living organisms	14
studies concerning	14
higher activity	14
specific binding	14
directly involved	14
saturated fatty	14
infectious bronchitis	14
acylated proteins	14
highly active	14
also reported	14
covalently linked	14
located within	14
primary protein	14
idps idprs	14
proline residues	14
specific expression	14
mucosal cell	14
trifluoroacetic acid	14
pulmonary disease	14
liver disease	14
large intestine	14
human cell	14
using high	14
peptide substrates	14
alternative oxidase	14
cell activation	14
higher affinity	14
time points	14
sequence identity	14
drug release	14
blood samples	14
structural analogues	14
lesser extent	14
also inhibited	14
molecular level	14
life cycle	14
cleavage site	14
protein level	14
peel extracts	14
binding mode	14
dna polymerase	14
nontransformed roots	14
targeted delivery	14
activating factor	14
acid hydroxylase	14
body mass	14
hospital stay	14
linked oligosaccharides	14
extensively studied	14
positive cells	14
peptide interactions	14
fi ndings	14
key enzymes	14
click reaction	14
series gangliosides	14
sachs disease	14
binding assay	14
brush border	14
next step	14
lemon juice	14
recently shown	14
human liver	14
results demonstrated	14
obtained results	14
lysine residues	14
heart rate	14
nontransgenic roots	14
contact time	14
expression system	14
spectrometry analysis	14
human tissues	14
steric hindrance	14
take place	14
gd synthase	14
functional group	14
significant amounts	14
homologous recombination	14
protein fragments	14
protein amino	14
well plate	14
single amino	14
dna gyrase	14
peptide analogs	14
cytoplasmic tail	14
clinical applications	14
beneficial effect	14
environmental factors	14
class ii	14
gastric acid	14
another important	14
adaptive immunity	14
give rise	14
extract inhibits	14
rich region	14
acid functionalized	14
great importance	14
among others	14
cardiovascular diseases	14
hemolytic activity	14
cos cells	14
financial support	14
dietary fat	14
neutral ph	14
real time	14
coding region	14
target cell	14
maldi analysis	14
also studied	14
glutamate release	14
capsid proteins	14
intestinal absorption	14
matrix metalloproteinases	14
experiments showed	14
bene fi	14
egg white	14
focused teaching	13
final product	13
significant decrease	13
nutrition rev	13
may explain	13
kinetic parameters	13
chemical modifications	13
bacillus anthracis	13
per year	13
lactate dehydrogenase	13
block oligonucleotides	13
surface antigen	13
antibody recognition	13
many cases	13
cd spectra	13
cationic antimicrobial	13
side reactions	13
conformational preferences	13
autosomal recessive	13
peptide dendrimers	13
two decades	13
derived peptide	13
acid supplementation	13
listeria monocytogenes	13
inclusion bodies	13
fmoc chemistry	13
containing amino	13
charged amino	13
recent developments	13
tubular acidosis	13
gene transfer	13
heavy metal	13
research institute	13
data acquisition	13
associated protein	13
biosynthetic pathways	13
reactive protein	13
pharmacokinetic study	13
purified using	13
cdna library	13
melanoma cell	13
long chain	13
sequence motifs	13
methyl gallate	13
historical development	13
previous reports	13
zeta potential	13
gene family	13
metal binding	13
data set	13
using standard	13
aminoisobutyric acid	13
infrared spectroscopy	13
translation initiation	13
angiotensin i	13
recently described	13
cytotoxic effects	13
small cell	13
yeast cells	13
batch cultures	13
statistically significant	13
functionalized gold	13
ligand interactions	13
glycosylation site	13
northern blot	13
mass spectroscopy	13
using maldi	13
antioxidant activities	13
total number	13
cerebral cortex	13
carrier protein	13
protein function	13
gene clusters	13
vitro assays	13
synthetic derivatives	13
protective effects	13
hydrophilic interaction	13
dipolar cycloaddition	13
new generation	13
acid biosynthesis	13
primary nec	13
dna fragmentation	13
another approach	13
affi nities	13
cells may	13
fermentation broth	13
aromatic residues	13
chemical modification	13
sugar chains	13
energy intake	13
experimental details	13
clinical isolates	13
protein engineering	13
gc ms	13
cryptococcus neoformans	13
liquid matrices	13
drug targets	13
nuclear antigen	13
previous work	13
biological membranes	13
peptide containing	13
lignocellulosic biomass	13
currently used	13
lead compounds	13
proteolytic enzymes	13
active transport	13
peripheral tissues	13
micromolar range	13
transgenic plants	13
protein tyrosine	13
digestive tract	13
acidic conditions	13
covalently bound	13
fruit peel	13
primary sequence	13
phase i	13
virus replication	13
male wistar	13
uorescence spectroscopy	13
alcohol intake	13
blood group	13
like peptide	13
mice lacking	13
low toxicity	13
receptor activation	13
two major	13
reducing power	13
mg protein	13
functional properties	13
cell extracts	13
results demonstrate	13
patients undergoing	13
starting point	13
white wines	13
protein complexes	13
scale production	13
protein ligation	13
basic amino	13
enzymatic digestion	13
pomegranate seeds	13
presentation will	13
high quality	13
posttranslational modification	13
natural peptides	13
modified peptides	13
metabolite production	13
graduate school	13
binding assays	13
based assay	13
viral infections	13
ion trap	13
enzymatic activities	13
aspartic acids	13
using two	13
acid transporter	13
human platelet	13
lipid bilayers	13
metabolic alkalosis	13
like activity	13
pure form	13
findings suggest	13
sandhoff disease	13
physiological processes	13
animal studies	13
structural properties	13
prepared using	13
zur bestimmung	13
pomegranate rind	13
lipid mediators	13
peptide arrays	13
analgesic effect	13
normal cells	13
significantly higher	13
anaerobic conditions	13
rgd sequence	13
major histocompatibility	13
inflammatory activity	13
wheat bran	13
mouth disease	13
molecular modelling	13
structure analysis	13
dietary sources	13
assisted solid	12
host defense	12
proton pump	12
cancer therapies	12
specific amino	12
phylogenetic analysis	12
sh domains	12
cell biology	12
relationship studies	12
surface sialic	12
maackia amurensis	12
designed based	12
acyl donor	12
moderate alcohol	12
dietary acid	12
synthetic strategy	12
roots compared	12
one study	12
hydrophobic amino	12
pfeifer barbosa	12
terminal peptide	12
taking advantage	12
adverse effects	12
major components	12
syndrome coronavirus	12
activity studies	12
positive control	12
conventional methods	12
experimental results	12
continuous epitopes	12
human blood	12
membrane surface	12
reaction times	12
causative agent	12
inflammatory processes	12
may induce	12
raw material	12
fl ammatory	12
contains two	12
genome sequence	12
base models	12
glycolic acid	12
negative control	12
different kinds	12
cholera toxin	12
competitive inhibitor	12
high selectivity	12
also shown	12
pomegranate juices	12
may increase	12
subcellular localization	12
less likely	12
soluble protein	12
glycans released	12
ciliary activity	12
life span	12
studies indicate	12
significant change	12
blood cell	12
many years	12
large amount	12
viral vectors	12
novel approach	12
gene product	12
new type	12
toxic effects	12
growth conditions	12
rich pomegranate	12
posttranslational modifications	12
cell activity	12
cell entry	12
probably due	12
pharmacokinetic properties	12
peptide conformation	12
head groups	12
gluconic acid	12
quality control	12
chemical methods	12
viral nucleic	12
cyclic nucleotide	12
kg ha	12
university students	12
carbohydrate metabolism	12
antibacterial agents	12
aided design	12
transport system	12
linear peptides	12
new therapeutic	12
often used	12
high blood	12
structure elucidation	12
urea cycle	12
schwann cells	12
data show	12
structure determination	12
amyloid formation	12
base chemistry	12
crude extract	12
gastric juice	12
neutral ceramidase	12
gut microbiota	12
xenopus oocytes	12
seed extract	12
metabolic fluxes	12
size exclusion	12
terminal residues	12
drinking water	12
mechanisms involved	12
time course	12
microwave irradiation	12
insulin receptor	12
increased significantly	12
alcoholic beverages	12
large part	12
surface expression	12
human erythrocytes	12
new insights	12
fatty liver	12
receptor subtype	12
acute lymphoblastic	12
energy source	12
neutral amino	12
mediated delivery	12
systemic inflammatory	12
different strategies	12
compounds containing	12
prediction method	12
lymph nodes	12
neuraminidase treatment	12
carcinogenic cells	12
synaptic plasticity	12
tof analysis	12
imaging mass	12
physical properties	12
serum glycoproteins	12
ray crystallography	12
mitochondrial membrane	12
methods used	12
guinea pig	12
mannose residues	12
untersuchungen fiber	12
thiol groups	12
fl uenza	12
biological roles	12
amadori products	12
ms spectra	12
inhibitory concentration	12
hydrophobic core	12
peptide structure	12
neisseria meningitidis	12
casd gene	12
web server	12
isolated rat	12
trichogin ga	12
glutathione peroxidase	12
ower extract	12
human intestinal	12
results revealed	12
fruit rind	12
food additives	12
studies suggest	12
acid etching	12
light chain	12
new zealand	12
virus particles	12
physiological role	12
growing interest	12
juice polyphenols	12
peptide drugs	12
like protein	12
stranded dna	12
vegetable oils	12
will focus	12
chronic inflammation	12
functional food	12
glycan release	12
nude mice	12
salt concentration	12
protein content	12
therapeutic approach	12
peptides will	12
normal tissues	12
da release	12
anion exchange	12
lonicerae preparations	12
bind sialic	12
acid analogues	12
glucose tolerance	12
peptide inhibitors	12
antigen presentation	12
kinetic studies	12
various cell	12
risk factor	12
three groups	12
human neutrophils	12
like particles	12
also tested	12
aureobasidium pullulans	12
first isolated	12
terminal sequence	12
monomeric sugars	12
membrane phospholipids	12
rna polymerase	12
identi fi	12
ga iv	12
treated mice	12
peptides based	12
reaction conditions	12
experimental group	12
three times	12
parietal cells	12
two steps	12
proteins using	12
covalent attachment	12
evening primrose	12
dependent kinase	12
higher concentration	12
hydrolyzable tannins	12
matrix proteins	12
best results	12
frequently used	12
molar ratio	12
surface receptor	12
glycyrrhizic acid	12
antimicrobial effect	12
ionization time	12
ovary cells	12
dynamic light	12
vaccinia virus	12
human growth	12
fluorescence spectroscopy	12
adult rats	12
ionic liquids	12
initiation factor	12
human lung	12
volatile fatty	12
rat model	12
lipid composition	12
dengue virus	12
taurine depletion	12
two amino	12
double mutant	11
showed higher	11
conformational space	11
severe sepsis	11
releasing hormone	11
ds brain	11
die wirkung	11
major source	11
food products	11
selective binding	11
phosphorylation sites	11
will show	11
peptides showed	11
spent grain	11
cantly increased	11
potential use	11
gastric emptying	11
terminal end	11
gnrh analogues	11
structural elements	11
sphingolipid metabolism	11
animal feed	11
weakly basic	11
peptides isolated	11
glycosylated peptides	11
also involved	11
embryonic stem	11
newly developed	11
significant reduction	11
fl exibility	11
heterologous expression	11
achieved using	11
family members	11
different classes	11
independent phospholipase	11
membrane domains	11
stem ethanol	11
human influenza	11
puerto rico	11
peptide docking	11
spatial resolution	11
blood serum	11
well characterized	11
endophytic fungus	11
induce apoptosis	11
mouse peritoneal	11
antibiotic activity	11
specific protein	11
tyrosine kinases	11
transmission electron	11
virulence factor	11
protein domains	11
primary cultures	11
methanolic extract	11
primrose oil	11
conventional antibiotics	11
case study	11
expressing cells	11
alkaline conditions	11
dna synthesis	11
inner membrane	11
functional characterization	11
also performed	11
ionic strength	11
cell debris	11
cell lysates	11
increased levels	11
several types	11
detection limit	11
cantly decreased	11
binding affinities	11
biofi lm	11
different chemical	11
surgical patients	11
peptide hybrids	11
antibody binding	11
fruit juice	11
metabolic network	11
platelet activation	11
new peptides	11
acid nanoparticles	11
tetrafl uoroborates	11
clinical evidence	11
skeletal muscles	11
atpase activity	11
induced oxidative	11
poor solubility	11
significantly different	11
triglyceride lipase	11
differentially expressed	11
anammox bacteria	11
data bank	11
membrane rafts	11
growth regulators	11
sar studies	11
mannose glycans	11
lactobacillus plantarum	11
linked glycopeptides	11
protein purification	11
provide new	11
specific antigen	11
ed peptides	11
surface proteins	11
binding pocket	11
inhibitory concentrations	11
main chain	11
highly variable	11
plant polysaccharides	11
higher levels	11
expanded bed	11
acid moiety	11
induced diabetic	11
drosophila melanogaster	11
peptide complexes	11
peptide chains	11
consensus sequence	11
mobile phase	11
different proteins	11
tissue culture	11
klebsiella pneumoniae	11
exclusion chromatography	11
bovine coronavirus	11
extract exhibited	11
acid also	11
several diseases	11
healthy human	11
covalently attached	11
therapeutic strategies	11
lipid membrane	11
critical illness	11
significant changes	11
enzyme preparation	11
force field	11
peptide ligation	11
novel method	11
carboxyl groups	11
virucidal activity	11
fluorescent protein	11
chemoenzymatic synthesis	11
glucose homeostasis	11
ph conditions	11
kinase activity	11
novel antimicrobial	11
machine learning	11
xylitol production	11
keto acids	11
chronic obstructive	11
reperfusion injury	11
small proteins	11
dry matter	11
membrane potential	11
long time	11
mouse liver	11
methylene group	11
cantly reduced	11
whole blood	11
useful tool	11
atomic force	11
carbon nanotubes	11
specific antibodies	11
fluorescence intensity	11
false positives	11
expression systems	11
stearic acid	11
polysia chains	11
gm ganglioside	11
rich proteins	11
clinical nutrition	11
peptide fragment	11
play important	11
succinic acid	11
quite different	11
less potent	11
fl exible	11
moderate wine	11
clostridium perfringens	11
oxidative damage	11
universal exchange	11
vibrio cholerae	11
sars coronavirus	11
kidney cells	11
biological significance	11
system using	11
disease progression	11
protein glycosylation	11
acid delivery	11
low level	11
low mw	11
amyloid fi	11
cytotoxic effect	11
allow us	11
high school	11
functional roles	11
active center	11
human embryonic	11
genetically engineered	11
synthetic methods	11
phosphate dehydrogenase	11
acetyl gd	11
cell mass	11
like growth	11
membrane interactions	11
see table	11
care unit	11
helical structures	11
false positive	11
common cold	11
study showed	11
base disturbances	11
methanol extract	11
molecular interactions	11
canary islands	11
proteome analysis	11
genetically modified	11
cellular delivery	11
capsid protein	11
affinity binding	11
carboxylic group	11
dna viruses	11
arginine transport	11
benefi cial	11
controlled release	11
milk oligosaccharides	11
heavy metals	11
intestinal secretion	11
level digraph	11
functional studies	11
peptides corresponding	11
specific sirna	11
alkaline ph	11
past years	11
factor kappa	11
also examined	11
anthrax toxin	11
coupling reagent	11
milk fat	11
beta cells	11
biofilm formation	11
increasing number	11
modern humans	11
dna repair	11
obstructive pulmonary	11
sequence alignment	11
high concentration	11
coupling reactions	11
peptide concentration	11
rat uterus	11
momordica charantia	11
data analysis	11
terminal cysteine	11
treated cells	11
carcinoma cell	11
plasma concentration	11
leading cause	11
transfer rate	11
high amounts	11
cell walls	11
functional role	11
significantly enhanced	11
already known	11
alkaline phosphatase	11
nucleotide sequence	11
novo design	11
heavy chain	11
fl uorinated	11
metabolic activity	10
lysosomal storage	10
ml min	10
stress conditions	10
low mass	10
mast cell	10
molecular analysis	10
intestinal epithelial	10
type iii	10
inhibitory action	10
peptide molecules	10
may serve	10
site directed	10
virus hemagglutinin	10
overall yield	10
inhibition activity	10
activation energy	10
glutamate receptor	10
cyclic rgd	10
group iii	10
methods using	10
chiral centers	10
fermentation conditions	10
food science	10
time consuming	10
rats treated	10
ef fi	10
bacterial cells	10
phylogenetic tree	10
mass spectrum	10
one hand	10
skin cancer	10
protein family	10
phase hplc	10
regulatory peptides	10
clinically relevant	10
caffeoylquinic acids	10
including cancer	10
still unknown	10
attractive target	10
cas protein	10
inflammatory effects	10
cultures using	10
pro residue	10
regulatory mechanisms	10
new technique	10
protected peptide	10
mediated via	10
mouse mammary	10
concentration range	10
cells expressing	10
antigenic determinants	10
cellular processes	10
mrna level	10
phenolic content	10
gynostemma pentaphyllum	10
growth cones	10
shock protein	10
patients suffering	10
stimulating hormone	10
stimulatory effect	10
preliminary data	10
plant secondary	10
enclosed within	10
orthogonally protected	10
basic protein	10
geobacter sulfurreducens	10
sulfate groups	10
double bonds	10
biological systems	10
measured using	10
viral envelope	10
proinflammatory cytokines	10
defined medium	10
signalling pathways	10
cleavage sites	10
two enzymes	10
phosphate pathway	10
dpc micelles	10
ray structure	10
therapeutic targets	10
bronchitis virus	10
based therapies	10
acidic amino	10
total parenteral	10
acid transporters	10
pathogen interactions	10
phagocytic activity	10
acyl chains	10
protein intake	10
tissue regeneration	10
acid moieties	10
biochemical characterization	10
peptide mass	10
biotechnology institute	10
also associated	10
reverse transcription	10
mg dl	10
cytosolic phospholipase	10
fluorescently labeled	10
national research	10
human ata	10
orally active	10
neonatal rat	10
domain swapping	10
trans isomerization	10
histocompatibility complex	10
dairy cows	10
induced cell	10
receptor determinant	10
developmental stages	10
small amount	10
activity compared	10
hydrolysis products	10
scientific research	10
many viruses	10
acid esters	10
aminopeptidase type	10
pdb id	10
antibody production	10
based design	10
animal species	10
minimum inhibitory	10
proteins may	10
qc samples	10
acids within	10
may help	10
salivary ph	10
base pairs	10
co incubator	10
bacillus thuringiensis	10
lund university	10
antibiotic resistance	10
food ingredients	10
catalytic site	10
east technical	10
wang resin	10
sulfate proteoglycans	10
intestinal malabsorption	10
bioactive peptide	10
helix formation	10
may affect	10
epigallocatechin gallate	10
ulcerative colitis	10
cytometric analysis	10
lipid membranes	10
conformationally constrained	10
individual proteins	10
target gene	10
consumption rate	10
high efficiency	10
several hundred	10
various parts	10
also called	10
preclinical studies	10
large variety	10
human evolution	10
bactericidal activity	10
fi cation	10
developmentally regulated	10
cafeteria diet	10
potential applications	10
signalling pathway	10
clinical application	10
physiological state	10
metabotropic glutamate	10
storage diseases	10
campylobacter jejuni	10
coil structure	10
corona virus	10
peak areas	10
proteins containing	10
helix bundle	10
culture media	10
ion channel	10
mg per	10
analysis method	10
selective enrichment	10
parathyroid hormone	10
comparative analysis	10
neural cell	10
dietary supplement	10
new synthetic	10
analyzed using	10
potential role	10
also contribute	10
oxygen supply	10
pressure test	10
potentially useful	10
vice versa	10
neurological disorders	10
stable isotope	10
cellular functions	10
specific inhibitors	10
web servers	10
optimal ph	10
false negative	10
dna sequencing	10
natural peptide	10
labeled proteins	10
working volume	10
placebo group	10
released glycans	10
high sensitivity	10
atopic dermatitis	10
body protein	10
combinatorial chemistry	10
heart failure	10
coli strain	10
rationally designed	10
metabolic effects	10
functional significance	10
acetyl esterase	10
serviceberry fruits	10
analgesic activity	10
alternative conceptions	10
trichosanthes kirilowii	10
general formula	10
ceramide accumulation	10
activated receptor	10
novel class	10
see also	10
milk proteins	10
increased resistance	10
lymphocyte proliferation	10
host sialic	10
growth medium	10
successfully used	10
protein aggregation	10
physical activity	10
high doses	10
white wine	10
polysialic acids	10
many studies	10
metabolic energy	10
cells involved	10
induced dissociation	10
novel human	10
new family	10
enzyme active	10
peroxisome proliferator	10
viral fusion	10
general review	10
sodium hydroxide	10
cysteine proteases	10
matrix metalloproteinase	10
protein identification	10
extract showed	10
pore formation	10
evaluated using	10
potential drug	10
lung carcinoma	10
suffi cient	10
leucine zipper	10
present results	10
cell response	10
ace inhibitory	10
three peptides	10
connective tissue	10
using synthetic	10
sperm motility	10
fragment condensation	10
antifungal activities	10
viral replication	10
labeled peptides	10
current evidence	10
various concentrations	10
transport systems	10
intracellular ca	10
optical density	10
viral particles	10
pipecolic acid	10
nuclear extracts	10
structurally characterized	10
sambucus formosana	10
within minutes	10
cd cd	10
traditionally used	10
using solid	10
anticancer agents	10
medical applications	10
chinese medicine	10
cant decrease	10