bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
converting enzyme	1037
ang ii	672
angiotensin ii	558
ace inhibitors	476
blood pressure	319
heart failure	306
angiotensin system	262
acute respiratory	245
angiotensin converting	227
respiratory syndrome	208
ace activity	206
angiotensin i	202
severe acute	182
myocardial infarction	176
ace inhibitor	174
receptor blockers	162
coronavirus disease	159
novel coronavirus	154
ang i	148
lung injury	140
angiotensin receptor	139
ii receptor	134
syndrome coronavirus	131
ace inhibition	128
enzyme inhibitors	127
spike protein	120
smooth muscle	105
ii type	104
cardiovascular disease	104
hereditary angioedema	104
active site	103
sars coronavirus	98
amino acid	96
inh concentrate	93
angiotensinconverting enzyme	89
left ventricular	88
human ace	87
inh deficiency	86
gene expression	85
endothelial cells	85
type receptor	85
nitric oxide	80
severe covid	80
increased risk	79
clinical trials	75
ace expression	72
risk factors	72
amino acids	72
viral entry	71
ace gene	71
nervous system	71
respiratory distress	71
enzyme inhibition	71
epithelial cells	70
factor xii	70
neutral endopeptidase	70
aldosterone system	69
may also	64
ii levels	62
cord uid	62
distress syndrome	62
doc id	62
side effects	61
mas receptor	61
receptor antagonist	61
db mice	59
kidney disease	58
type i	58
type ii	56
clinical characteristics	55
oxidative stress	55
united states	55
i arbs	55
animal models	53
acute lung	52
diabetes mellitus	52
human angiotensin	52
coronary artery	51
renin angiotensin	49
host cells	49
blood flow	49
ace protein	48
significantly increased	48
hypertensive rats	48
endothelial dysfunction	48
clinical trial	48
protein expression	47
inhibitor therapy	47
middle east	46
severe disease	46
systematic review	46
coronavirus infection	46
vascular smooth	45
human coronavirus	44
increased ace	44
type diabetes	43
critically ill	43
heart rate	43
receptor blocker	42
east respiratory	42
diabetic nephropathy	42
cell surface	42
mas axis	41
intensive care	40
inhibitor deficiency	40
knockout mice	40
hypertensive patients	40
growth factor	40
ace ace	40
pulmonary hypertension	40
adverse effects	40
angioedema attacks	40
channel blockers	39
respiratory tract	39
recombinant human	38
hereditary angioneurotic	38
muscle cells	38
cohort study	38
infected patients	38
immune system	38
potentiating peptides	38
renin receptor	38
risk factor	38
cell entry	38
calcium channel	38
receptor blockade	38
active sites	38
herd immunity	38
heart disease	37
spontaneously hypertensive	37
somatic ace	37
beta blockers	37
enzyme inhibitor	37
diabetic mice	37
viral replication	37
system inhibitors	36
nh gene	36
clinical course	36
induced lung	36
among patients	36
transgenic mice	36
cytokine storm	36
receptor antagonists	36
world health	35
sars cov	35
kcal mol	35
functional receptor	35
patients infected	35
health organization	35
insulin administration	35
central nervous	35
host cell	34
enzyme gene	34
also known	34
congestive heart	34
disease severity	34
ventricular dysfunction	34
ang iv	34
cont mice	34
vascular endothelial	33
important role	33
ischemic stroke	33
cardiac output	33
related carboxypeptidase	32
inflammatory cytokines	32
higher risk	32
lung fibrosis	32
ejection fraction	31
ill patients	31
deletion polymorphism	31
hae attacks	31
brain ras	31
enzyme activity	31
deficient mice	31
binding site	31
cardiovascular diseases	31
copyright holder	30
esterase inhibitor	30
patients receiving	30
output loss	30
immune response	30
crystal structure	30
i converting	30
angioneurotic edema	29
protease inhibitor	29
potential therapeutic	29
hae type	29
ace levels	28
serine protease	28
inhibitor gene	28
mortality rate	28
european society	28
molecular weight	28
hospitalized patients	28
artery disease	28
granted medrxiv	28
death rates	28
viral infections	28
beneficial effects	28
author funder	28
ace may	27
receptor stimulation	27
converts angiotensin	27
ang iii	27
substrate specificity	27
vascular resistance	27
coronavirus spike	27
soluble ace	27
organ damage	27
binding domain	27
vascular permeability	27
ace ang	27
essential hypertension	26
mrna expression	26
patients treated	26
chronic kidney	26
drosophila melanogaster	26
cov infection	26
enzymatic activity	26
icu admission	26
insect ace	26
type iii	26
antihypertensive drugs	26
lung tissue	26
plasminogen activator	26
viral load	25
mineralocorticoid receptor	25
ace homologues	25
immune responses	25
nonallergic angioedema	25
angiotensin peptides	25
bradykinin potentiating	25
risk group	25
atrial fibrillation	25
may contribute	25
rbd ace	25
pressure regulation	24
receptor ace	24
transforming growth	24
enzyme angiotensin	24
action potential	24
receptor binding	24
gpiase activity	24
gastrointestinal tract	24
receptor gene	24
fatality rate	24
term prophylaxis	24
anchored proteins	24
plasma kallikrein	24
spike proteins	24
chronic heart	24
clinical features	24
significantly higher	24
mouse model	24
blood vessels	24
control group	24
system blockers	24
may result	24
human lung	24
protein kinase	24
patients taking	23
two active	23
death rate	23
viral rna	23
angiotensin type	23
peer review	23
brain tissue	23
reninangiotensin system	23
cell membrane	23
renal disease	23
acc aha	23
sequence identity	23
uncaria tomentosa	23
inflammatory response	23
care unit	23
right ventricle	23
abdominal pain	23
attenuated androgens	23
peptidase activity	23
phase ii	23
ras components	22
insertion deletion	22
heart function	22
influenza virus	22
inh function	22
laryngeal edema	22
lopinavir ritonavir	22
cleavage site	22
lung failure	22
gene promoter	22
public health	22
ace receptor	22
retrospective cohort	22
clinical studies	22
case series	21
viral infection	21
controlled trial	21
late stages	21
contact system	21
novel angiotensin	21
expression levels	21
plasma levels	21
right ventricular	21
hereditary angio	21
receptor activation	21
zinc ion	21
crucial role	21
renin inhibitor	21
kinin system	21
ace knockout	21
wide range	21
widely used	21
mechanical ventilation	21
animal studies	21
tissue distribution	21
acute myocardial	21
recombinant ace	21
may increase	21
hepatic fibrosis	21
version posted	21
receptor expression	20
natriuretic peptides	20
lung cells	20
statistically significant	20
virus infection	20
blood glucose	20
ii receptors	20
clinical manifestations	20
proximal tubule	20
coupled receptor	20
cardiac angiotensin	20
posted june	20
protective role	20
replacement therapy	20
inhibitors arbs	20
functional expression	20
ace axis	20
new coronavirus	20
convalescent plasma	20
circulating ace	20
inherited angioedema	20
affected patients	20
tg mice	20
renin activity	20
receptor axis	20
refractory period	19
portal pressure	19
current smokers	19
liver fibrosis	19
catalytically active	19
spike glycoprotein	19
hospital mortality	19
akita mice	19
lower respiratory	19
clinical data	19
left ventricle	19
cardiovascular system	19
ventricular hypertrophy	19
respiratory failure	19
enzyme protects	19
mortality rates	19
liver disease	19
structural proteins	19
therapeutic target	19
increased expression	19
general population	19
reactive oxygen	19
case fatality	19
increased levels	19
human plasma	18
myocardial injury	18
signal transduction	18
ii formation	18
kidney injury	18
receptor agonist	18
plasma concentrations	18
corona virus	18
protective effects	18
alveolar epithelial	18
ace angiotensin	18
natriuretic peptide	18
sympathetic nervous	18
two homologous	18
pulmonary fibrosis	18
molecular mechanisms	18
monoclonal antibody	18
tranexamic acid	18
medrxiv preprint	18
plasma membrane	18
sars virus	18
target cells	17
first step	17
converting enzymes	17
angiotensinogen gene	17
inhibitor binding	17
american college	17
acute attacks	17
pulmonary disease	17
anchored protein	17
odds ratio	17
inh concentration	17
recent studies	17
adam tace	17
another study	17
severe lethal	17
highly expressed	17
receptor mas	17
glucose levels	17
lung fibroblasts	17
patients admitted	17
oxide synthase	17
early stage	17
high risk	17
human renin	17
protease tmprss	17
randomized clinical	17
necrosis factor	17
renal function	17
binding sites	16
two domains	16
activity ratio	16
essential regulator	16
two groups	16
upper respiratory	16
virus entry	16
arterial hypertension	16
immune cells	16
binding pocket	16
health care	16
acquired angioedema	16
european countries	16
ace homologue	16
mitral valve	16
coronavirus sars	16
previous studies	16
terminal domain	16
drosophila ace	16
renal ace	16
reduced ace	16
plasma renin	16
bradykinin receptor	16
renin inhibitors	16
cardiac function	16
complement activation	16
homologous domains	16
high blood	16
arbs treatment	16
confirmed cases	16
proximal tubular	16
diabetic kidney	16
pulmonary vascular	16
home therapy	16
gene transcription	16
stem cells	16
protective effect	16
oxygen species	16
authors declare	16
clinical symptoms	16
inhibitors angiotensin	16
acute abdominal	16
circulating ras	16
gene polymorphisms	16
china clinical	15
cardiovascular risk	15
reuse allowed	15
new york	15
ebola virus	15
tissue ras	15
ace mrna	15
aldosterone synthase	15
binding affinity	15
signaling pathways	15
hungarian hae	15
observational study	15
drug design	15
related angioedema	15
neutralizing antibodies	15
allowed without	15
ace deletion	15
chronic obstructive	15
tissue ace	15
rights reserved	15
studies using	15
specific substrate	15
african americans	15
dengue virus	15
inhibitory activity	15
innate immune	15
rat model	15
cell proliferation	15
heart association	15
without permission	15
functional activity	15
interventricular septum	15
respiratory disease	15
higher levels	15
serine proteases	15
antihypertensive agents	15
akita hnrnpf	15
may lead	15
patients without	15
catalytic activity	15
biologically active	15
gene polymorphism	15
binding protein	15
rats angiotensin	15
entry depends	15
lung damage	15
portal hypertension	15
catalytic domain	15
clinically proven	15
pediatric patients	15
present study	15
diabetic patients	15
adrenal gland	15
inhibitor treatment	15
angiotensin iv	15
mammalian ace	15
key role	15
disease control	15
db db	15
proximal tubules	15
proven protease	15
higher mortality	15
data suggest	15
membrane protein	15
human airway	15
control study	14
chronic use	14
task force	14
gpi anchor	14
mice lacking	14
i hereditary	14
angioneurotic oedema	14
cardiac fibrosis	14
molecular biology	14
receptor subtypes	14
many different	14
different tissues	14
angiotensin systems	14
kinin peptides	14
aceis arbs	14
human homolog	14
factor xiia	14
obstructive pulmonary	14
major role	14
phase i	14
angiotensin receptors	14
right coronary	14
new therapeutic	14
ii generation	14
induced acute	14
syncytial virus	14
clinical implications	14
clinical use	14
randomised trial	14
creative commons	14
protease inhibitors	14
tissue kallikrein	14
tumor necrosis	14
american heart	14
respiratory syncytial	14
glycosylation sites	14
hypertension hospitalized	14
gender differences	14
side chain	14
angioedema associated	14
increased ang	14
edematous attacks	14
cause mortality	14
icu care	14
might also	14
antiviral activity	14
cell types	14
randomized controlled	14
second messenger	14
acute attack	14
neprilysin inhibitor	14
dipeptidyl peptidase	14
aortic stenosis	14
proteolytic activation	14
severe cases	14
significantly decreased	14
clinical practice	14
brush border	14
intracellular calcium	13
induced hypertension	13
cell culture	13
deaths due	13
pulmonary vasoconstriction	13
potential role	13
receiving ace	13
may occur	13
classical ras	13
insensitive carboxypeptidase	13
observational studies	13
increasing ace	13
peptide levels	13
acid sequence	13
cardiovascular events	13
rat heart	13
western blotting	13
human cells	13
tubular cells	13
ii production	13
rat brain	13
whereas ace	13
understanding sars	13
less likely	13
hypertensive subjects	13
liquid chromatography	13
inh concentrations	13
elderly patients	13
endothelial function	13
specific inhibitor	13
significant increase	13
adverse events	13
specific ace	13
local ras	13
integral membrane	13
ras system	13
tissue injury	13
clinical outcomes	13
angioedema caused	13
potent inhibitor	13
biological peptides	13
viral loads	13
retrospective study	13
stroke volume	13
lethal disease	13
antifibrinolytic agents	13
aortic valve	13
taking ace	13
guinea pig	13
late stage	13
molecular cloning	13
ethnic groups	13
patients hospitalized	13
sex hormones	13
catalytic site	13
high levels	13
renal angiotensin	13
md simulation	13
clinical presentation	13
adjusted hr	13
mortality among	13
peripheral vascular	13
ventricular arrhythmias	13
acid residues	13
adult inpatients	13
renin prorenin	13
specific inhibitors	13
uncaric acid	13
local renin	13
rna viruses	13
ace i	13
may cause	13
ace deficiency	12
may play	12
activator inhibitor	12
decreased ace	12
therapeutic implications	12
cell death	12
chain reaction	12
recurrent angioedema	12
airway epithelium	12
like activity	12
insulin resistance	12
selective inhibitors	12
lung disease	12
results suggest	12
ventricular tachycardia	12
cardiovascular effects	12
nep may	12
made available	12
monoclonal antibodies	12
increased mortality	12
transmembrane domain	12
drug classes	12
side effect	12
possible role	12
significant difference	12
myocardial ischemia	12
like enzyme	12
optimal lockdown	12
small intestine	12
high level	12
human heart	12
type mice	12
injury angiotensin	12
dependent enhancement	12
coronary blood	12
aldosterone secretion	12
studies showed	12
antiviral drugs	12
may explain	12
terminal catalytic	12
raas antagonists	12
also observed	12
ectodomain shedding	12
incubation period	12
orally active	12
beta blocker	12
significantly reduced	12
molecular basis	12
mas receptors	12
polymerase chain	12
glomerular injury	12
recent study	12
significant differences	12
mild symptoms	12
nuclear factor	12
attack therapy	12
transmission rate	12
one study	12
dendritic cells	12
ace also	12
active renin	12
acute coronary	12
also showed	12
coronary sinus	12
sars pathogenesis	12
factors associated	12
membrane fusion	12
bat origin	12
patients may	12
taken together	12
chronic angiotensin	12
coronary arteries	12
danazol treatment	12
dipeptidyl carboxypeptidase	12
harmful effects	12
physiological functions	12
risk patients	12
study group	12
inflammatory effects	12
endothelial cell	12
transgenic rats	12
well tolerated	12
weight kininogen	12
rna polymerase	12
promoter activity	12
several studies	12
endopeptidase activity	12
using ace	12
administration significantly	11
biological activity	11
hydrogen bond	11
younger subjects	11
domain specific	11
determine whether	11
infected individuals	11
inh protein	11
also found	11
failure angiotensin	11
related coronavirus	11
mg daily	11
high mortality	11
potent vasoconstrictor	11
sequence homology	11
tissue angiotensin	11
disease course	11
vascular disease	11
selective inhibitor	11
angina pectoris	11
drosophila angiotensin	11
virus may	11
ii pneumocytes	11
serum samples	11
circulating ang	11
prorenin receptor	11
controlled trials	11
chloride ion	11
oral contraception	11
coronavirus nl	11
renin gene	11
isolated perfused	11
rbd binding	11
two isoforms	11
pulmonary blood	11
normoxic recovery	11
female patients	11
position statement	11
ischaemic heart	11
vasoactive peptides	11
classical pathway	11
cardiovascular death	11
pathological conditions	11
inhibitory effect	11
adipose tissue	11
within hours	11
right atrium	11
physiological processes	11
infectious diseases	11
activated protein	11
mas pathway	11
two patients	11
reduced ejection	11
male fertility	11
renal injury	11
many patients	11
hfsa acc	11
outflow tract	11
hemoregulatory peptide	11
catalytic domains	11
brain renin	11
bothrops jararaca	11
coronavirus infections	11
arachidonic acid	11
alveolar macrophages	11
testis ace	11
randomized trial	11
airway epithelia	11
may help	11
study clinical	11
blood volume	11
map kinase	11
musca domestica	11
significantly lower	11
analysis revealed	11
like ace	11
coronavirus pneumonia	11
abdominal attacks	11
mouse models	11
disease states	11
pressure lowering	11
coronavirus receptor	11
internal medicine	11
aldosterone levels	11
factor xia	11
angiotensin iii	11
vitro studies	11
ace activities	11
even though	11
international license	11
significant reduction	11
human coronaviruses	11
inhibition may	11
cerebrospinal fluid	11
expression profiling	11
patients undergoing	11
antihypertensive effects	11
enzyme homologue	11
muscle contraction	11
cardiac hypertrophy	10
two forms	10
protein levels	10
mrna levels	10
severe coronavirus	10
increases ace	10
also shown	10
inhibitory effects	10
therapeutic targets	10
binding motif	10
perfusion pressure	10
regression analysis	10
receptor type	10
novel therapeutic	10
negative feedback	10
conformational change	10
ace shedding	10
large number	10
therapeutic potential	10
circumflex artery	10
null mice	10
ace genes	10
small molecule	10
lower risk	10
fatal outcomes	10
severe heart	10
virus disease	10
receptor antagonism	10
patients suffering	10
higher prevalence	10
increased susceptibility	10
experimental studies	10
nadph oxidase	10
mild disease	10
reduced risk	10
hemodynamic effects	10
arb use	10
per month	10
essential role	10
alzheimer disease	10
treated patients	10
signal peptide	10
modify ace	10
structural studies	10
kinin inactivation	10
wide variety	10
imr cells	10
influenza viruses	10
outcomes among	10
raas inhibition	10
chloride ions	10
inhibitor concentrate	10
significant role	10
hae center	10
somatic angiotensin	10
informed consent	10
arbs may	10
ras dysregulation	10
angiotensin peptide	10
recent years	10
previously reported	10
renal ang	10
renal proximal	10
iconverting enzyme	10
rat ace	10
different mechanisms	10
myocardial contractility	10
induced contraction	10
acei arb	10
contact activation	10
significant effect	10
pulmonary edema	10
zika virus	10
abdominal attack	10
binding interface	10
hormone replacement	10
wall thickness	10
increasing amounts	10
organ failure	10
chinese center	10
cellular entry	10
without affecting	10
general practitioners	10
injury induced	10
class i	10
viral proteins	10
xii activation	10
adult patients	10
case reports	10
negative regulator	10
peptide substrates	10
extracellular matrix	10
ras activity	10
dependent manner	10
failure patients	10
inpatient use	10
vascular endothelium	10
acei arbs	10
treatment options	10
hypertension treatment	10
kininase ii	10
ii stimulates	10
experimental models	10
dry cough	10
mucociliary clearance	10
molecular docking	10
peptide metabolism	10
recent report	10
structural basis	10
ischemic heart	10
based drug	10
airway epithelial	10
lung cancer	10
disease progression	10
like protease	10
vasoactive peptide	10
viral clearance	10
may present	10
aminocaproic acid	10
neprilysin inhibition	10
antihypertensive medications	9
messenger rna	9
arb therapy	9
intestinal wall	9
generating ang	9
coupled receptors	9
clinical benefit	9
cytokine release	9
cardiac arrest	9
ventricular outflow	9
hae attack	9
cell rna	9
black african	9
study conducted	9
innate immunity	9
case report	9
human brain	9
pivotal role	9
drug treatment	9
room temperature	9
much less	9
smoking status	9
addresses concerns	9
kidney diseases	9
terminal dipeptide	9
physiological relevance	9
inhibitors may	9
hospital admission	9
older age	9
reflex tachycardia	9
ace orthologous	9
enzyme responsible	9
type natriuretic	9
ace might	9
alphitobius diaperinus	9
hageman factor	9
family members	9
logistic regression	9
coronary syndrome	9
fold increased	9
pulmonary diseases	9
ii degradation	9
tissue levels	9
also increased	9
least one	9
pig ileum	9
severe lung	9
lockdown policy	9
intravascular coagulation	9
statement addresses	9
wall tension	9
ras imbalance	9
soluble form	9
vivo studies	9
inflammatory mediators	9
left atrium	9
therapeutic approaches	9
fold increase	9
inflammatory markers	9
social distancing	9
postmenopausal women	9
ace ratio	9
ulcerative colitis	9
critical care	9
clinical benefits	9
emerging data	9
lethal covid	9
line therapy	9
performed using	9
per day	9
brain barrier	9
ace insertion	9
lesser mealworm	9
myocardial oxygen	9
tissue sites	9
disseminated intravascular	9
using raas	9
hyperoxic gas	9
serum angiotensin	9
cell growth	9
class iii	9
virus safety	9
pressure reduction	9
increased amounts	9
effective treatment	9
patients showed	9
gene encoding	9
broad spectrum	9
commonly used	9
chronic hepatitis	9
fetal lung	9
express ace	9
peripheral vasodilation	9
angiotensinogen mrna	9
different organs	9
phase depolarization	9
tissue ang	9
catalytic properties	9
blocking drugs	9
york city	9
total deaths	9
generate ang	9
therapeutic effects	9
pneumonia outbreak	9
mg dl	9
circulating levels	9
mice angiotensin	9
endothelial nitric	9
ace structure	9
lupus erythematosus	9
chronic ace	9
statistical significance	9
described previously	9
high concentrations	9
rat kidney	9
arterial pressure	9
structural requirements	9
ace converts	9
low molecular	9
cells angiotensin	9
median age	9
substrate binding	9
pressure control	9
high affinity	9
viral spike	9
total rna	9
therapeutic benefits	9
ng ml	9
glomus cells	9
disease angiotensin	9
ventricular systolic	9
catalytic zinc	9
recombinant soluble	9
dependent inherited	9
vascular inflammation	9
possible mechanisms	9
ace homolog	9
natural products	9
negative charge	9
aha statement	9
dd genotype	9
infected pneumonia	9
human recombinant	9
domain ace	9
proinflammatory cytokines	9
safety profile	9
serum concentrations	9
human tace	9
tissue damage	9
human tissues	9
correlated inversely	9
camostat mesylate	9
gene family	9
critical residues	9
available data	9
reliance level	9
two classes	9
pulmonary arterial	9
elevated levels	9
pilot study	9
highly selective	9
included studies	9
ras blockade	9
high prevalence	9
receptor signaling	9
immunodeficiency virus	9
factors may	9
ang peptides	9
direct renin	9
receptor angiotensin	9
ace polymorphisms	9
high molecular	8
sodium retention	8
study showed	8
performance liquid	8
immune function	8
like symptoms	8
mass spectrometry	8
venous thromboembolism	8
viral particles	8
may potentiate	8
different cell	8
nep expression	8
novel homologue	8
ace enzyme	8
protein coupled	8
ras may	8
circulating angiotensin	8
cell lines	8
stem cell	8
troponin levels	8
potentiating peptide	8
fatty acids	8
peptidyl dipeptidase	8
first case	8
nod mice	8
beneficial effect	8
action potentials	8
normal cardiac	8
antifibrotic effects	8
common side	8
bradykinin receptors	8
without ligand	8
cohort studies	8
gene insertion	8
patients presenting	8
hypertension angiotensin	8
factor viii	8
high dose	8
study population	8
diabetic rats	8
activity may	8
small airway	8
kidney function	8
amyloid beta	8
drugs used	8
water retention	8
releasing hormone	8
two subdomains	8
angiotensin generation	8
proteolytic cleavage	8
lung inflammation	8
sars patients	8
adrenergic receptors	8
cardiovascular function	8
transmembrane serine	8
oxygen consumption	8
severe illness	8
human studies	8
melanogaster ace	8
systemic vascular	8
day follow	8
synergistic effect	8
either ace	8
expression may	8
pulmonary ras	8
germinal ace	8
white group	8
glucose uptake	8
standard care	8
muscle cell	8
many years	8
reactive protein	8
target protease	8
outbreak associated	8
symptomatic heart	8
experimental evidence	8
domain inhibitors	8
two distinct	8
functional characterization	8
raas inhibitors	8
cell signaling	8
tissue factor	8
inflammatory reactions	8
mesangial cells	8
hospitalized covid	8
peptide hormones	8
lymphocyte ratio	8
enzymatically active	8
proteolytic activity	8
hubei province	8
receptors may	8
avian influenza	8
hypoxic pulmonary	8
human immunodeficiency	8
regulated aminopeptidase	8
like enzymes	8
subgroup analysis	8
blocker therapy	8
arbs therapy	8
currently available	8
low dose	8
recorded diagnosis	8
relatively low	8
crystal structures	8
class ii	8
drug therapy	8
better understanding	8
supplementary material	8
whether ace	8
cigarette smoking	8
systemic lupus	8
bk receptor	8
alveolar cells	8
angioedema patients	8
mg kg	8
higher incidence	8
normoxic gas	8
cell cultures	8
septic shock	8
inflammatory responses	8
potentiating compounds	8
current smoking	8
cardiac remodeling	8
evidence suggests	8
myocardial fibrosis	8
lowering blood	8
transmembrane protease	8
less frequently	8
esc council	8
collagen deposition	8
findings suggest	8
bound ace	8
adverse effect	8
national health	8
decreased ang	8
glycemic control	8
renal artery	8
increased vascular	8
left atrial	8
first time	8
lung diseases	8
inflammatory conditions	8
gp recorded	8
homologue ace	8
descending artery	8
angiotensinaldosterone system	8
drug discovery	8
arterial stiffness	8
cardiac fibroblasts	8
regulatory peptides	8
ace paralogous	8
ii metabolism	8
gene duplication	8
human monoclonal	8
signalling pathways	8
mice overexpressing	8
years ago	8
indel polymorphism	8
infected cells	8
future research	8
therapeutic strategy	8
deficiency workshop	8
family medicine	8
intermediate host	8
human angiotensinconverting	8
ras blockers	8
neurological manifestations	8
small study	8
drug development	8
md simulations	8
kallikrein inhibitor	8
inhibit ace	8
collagen synthesis	8
perfused rat	8
terminal active	8
studied tissues	8
docking studies	8
blood meal	8
survival benefit	8
cardiovascular implications	8
germ cells	8
free peritoneal	8
extracellular domain	8
inhibitory peptides	8
studies suggest	8
heterogeneous nuclear	8
serum ace	8
lung epithelial	8
quantitative mrna	8
complement components	8
transmembrane protein	8
dual therapy	8
mortality benefit	8
cell line	8
coronary perfusion	8
adrenal cortex	8
plasma bradykinin	8
enzyme ii	8
critical role	8
ang peptide	8
pressor response	8
alternative splicing	8
mast cell	8
probable bat	8
therapeutic strategies	8
peritoneal fluid	8
enzyme inhibitory	8
body weight	7
function angiotensin	7
norepinephrine release	7
higher ace	7
ras pathway	7
inhibitors reduce	7
two main	7
positive results	7
observed differences	7
nuclear proteins	7
classical axis	7
may influence	7
potentiating action	7
available evidence	7
transcription factor	7
mediates regulated	7
measured using	7
soluble human	7
furin cleavage	7
tace structure	7
biological functions	7
calcium channels	7
receptor agonists	7
preoperative prophylaxis	7
new insights	7
arb treatment	7
increase blood	7
ii induces	7
liver injury	7
prophylactic treatment	7
life cycle	7
cardiovascular complications	7
knockout sperm	7
pulmonary embolism	7
fulminant myocarditis	7
em structure	7
sinus node	7
ece homolog	7
increasing evidence	7
duplication event	7
effective refractory	7
effects associated	7
may exacerbate	7
cov spike	7
phosphinic peptide	7
renal outcomes	7
single gene	7
also demonstrated	7
ace enzymes	7
frontal cortex	7
papillary muscle	7
renal cortex	7
cardiac failure	7
single amino	7
survival study	7
cardiac tissue	7
fluorogenic peptide	7
inhibitors versus	7
inflammatory cells	7
increase ace	7
endocardial cushion	7
last decade	7
differential regulation	7
mutant protein	7
angiotensin iconverting	7
much higher	7
vascular injury	7
positive reference	7
precursor protein	7
may decrease	7
associated angioedema	7
although ace	7
biological effects	7
mortality associated	7
potential influence	7
female mice	7
dextran sulfate	7
group receiving	7
side chains	7
important lessons	7
amyloid angiopathy	7
competitive inhibitors	7
molecular mass	7
blood group	7
commons attribution	7
ace acts	7
significant decrease	7
failing human	7
placebo group	7
activity assay	7
clinical relevance	7
weight gain	7
cov replication	7
papillary muscles	7
carbon atoms	7
potentiating activity	7
skeletal muscle	7
endothelial growth	7
vascular beds	7
early phase	7
systolic blood	7
fold higher	7
cardiac myocytes	7
million people	7
gastric cancer	7
masr axis	7
well established	7
respiratory system	7
clinical management	7
increased incidence	7
also associated	7
sample size	7
ventricular mass	7
danazol therapy	7
spinal cord	7
angioedema attack	7
cardiovascular comorbidities	7
lamina propria	7
factor xi	7
differential expression	7
anopheles gambiae	7
lockdown measures	7
sex differences	7
vaccine arrival	7
per million	7
brain angiotensin	7
arb drugs	7
inositol phosphates	7
ii accumulation	7
cardiac action	7
untreated patients	7
ace gpiase	7
difficulty breathing	7
medical research	7
coronavirus entry	7
independent predictors	7
expressing cells	7
metabolic syndrome	7
pressure homeostasis	7
additional file	7
renal tubules	7
induced diabetic	7
tricuspid valve	7
inhibitor captopril	7
total number	7
direct evidence	7
commercially available	7
virtual screening	7
genome sequence	7
rat liver	7
lesser extent	7
new target	7
vasopeptidase inhibitor	7
evidence supporting	7
ventricular remodeling	7
interim guidance	7
coronavirus associated	7
calcium levels	7
blind placebo	7
drug administration	7
main protease	7
human transmission	7
sore throat	7
ace null	7
cells via	7
like peptide	7
associated coronavirus	7
molecular level	7
carbohydrate groups	7
bar chart	7
biochemical indexes	7
total protein	7
treatment may	7
worse outcomes	7
levels may	7
infect humans	7
neprilysin inhibitors	7
ncov infected	7
body mass	7
left circumflex	7
primary outcome	7
pacemaker cells	7
increased angiotensin	7
synthase inhibition	7
mass index	7
terminal part	7
new class	7
chart showing	7
pilot clinical	7
blood supply	7
mouse brain	7
vasoprotective axes	7
current evidence	7
receptor may	7
two enzymes	7
indirect deaths	7
heat shock	7
kinin receptor	7
mm tris	7
peptide ang	7
direct effect	7
upper airway	7
chest pain	7
carboxypeptidase angiotensin	7
therapeutic option	7
lower ace	7
study using	7
studied tissue	7
degrading enzymes	7
active peptides	7
plasma angiotensin	7
direct interaction	7
million cases	7
post hoc	7
proteolytic processing	7
based study	7
acid sequences	7
bk degradation	7
regulated ectodomain	7
low levels	7
increased plasma	7
pathway activation	7
also present	7
domain selectivity	7
bradykinin generation	7
less severe	7
adverse outcomes	7
renal failure	7
hepatic stellate	7
cell receptor	7
icu patients	7
african descent	7
intermediate hosts	7
reproductive system	7
mean age	7
ventricular function	7
heavily glycosylated	7
single domain	7
testing positive	7
circulatory system	7
edema formation	7
lipid raft	7
bk action	7
results showed	7
ii ang	7
domain active	7
membrane bound	7
induced angioedema	7
invertebrate ace	7
cellular receptor	7
antibody responses	7
creatine kinase	7
disease expression	7
carotid body	7
cardiogenic shock	7
cardiac conditions	7
human sace	7
hospitalised patients	7
renal fibrosis	7
laboratory diagnosis	7
human vascular	7
subfornical organ	7
term treatment	7
pichia pastoris	7
renal tubular	7
patients linked	7
protein interaction	7
active metabolite	7
peripheral blood	7
conformational changes	6
human testis	6
growth factors	6
among african	6
inh functional	6
two large	6
plate reader	6
facilitating viral	6
prevents tgf	6
therapeutic options	6
scientific societies	6
significant increases	6
functional conservation	6
coronary heart	6
higher expression	6
human somatic	6
initial conditions	6
key differences	6
ace genotype	6
significant effects	6
carboxyl group	6
ii effects	6
arg bradykinin	6
lipid metabolism	6
intrarenal renin	6
acute phase	6
like peptides	6
ace receptors	6
severe sars	6
reduced left	6
clinical improvement	6
gene deletion	6
first ace	6
severe abdominal	6
cardiology american	6
cardiac events	6
prevent sars	6
human body	6
impulse generation	6
serum levels	6
cell membranes	6
enzymatic degradation	6
highly conserved	6
rheumatoid arthritis	6
signaling pathway	6
human coronary	6
alternate promoters	6
including hypertension	6
negatively charged	6
novel virus	6
lung function	6
autoimmune diseases	6
ligand interactions	6
receptor upregulation	6
two axes	6
follicle wall	6
van der	6
high plasma	6
hypotensive effect	6
serum albumin	6
physiological function	6
prefusion conformation	6
complete protease	6
health records	6
gene transfer	6
receptor knockout	6
local angiotensin	6
low doses	6
prospective cohort	6
systolic dysfunction	6
type diabetic	6
open reading	6
general reliance	6
unless otherwise	6
heme oxygenase	6
domain protein	6
protein structure	6
commons licence	6
intrinsic pathway	6
vascular leakage	6
vital role	6
cardiac injury	6
also expressed	6
epithelial cell	6
endothelin converting	6
motion important	6
vascular events	6
diastolic depolarization	6
kinin formation	6
may serve	6
ace cleaves	6
cell fusion	6
objective function	6
receptor neprilysin	6
angioedema may	6
mouse kidney	6
vascular damage	6
positive patients	6
human health	6
relative risk	6
drug targets	6
mm hg	6
hematopoietic stem	6
molecular dynamics	6
may regulate	6
lcz group	6
chronic diseases	6
primary structure	6
point mutations	6
major cardiovascular	6
small number	6
peptide receptor	6
testicular ace	6
therapeutic agent	6
ff complement	6
treated cells	6
bombyx mori	6
antiviral compounds	6
nuclear ribonucleoprotein	6
relatively small	6
sinoatrial node	6
confounding variables	6
may prevent	6
multiple sclerosis	6
vasopeptidase inhibition	6
porcine coronary	6
human receptor	6
pathogenic coronaviruses	6
released egfp	6
functional ace	6
atrioventricular node	6
dyax corp	6
concomitant use	6
many countries	6
potential risk	6
transmission dynamics	6
blood cells	6
protein releasing	6
deduced amino	6
also plays	6
type plasminogen	6
receptor subtype	6
usually associated	6
shock protein	6
positively charged	6
rabbit lung	6
activity correlated	6
human respiratory	6
peripheral vasodilator	6
systemic blood	6
potentiating nonapeptide	6
high glucose	6
disease patients	6
human tissue	6
raas components	6
million reads	6
biochemical properties	6
inhibitor rxpa	6
ras activation	6
practice guidelines	6
least two	6
study design	6
nh mutations	6
angiotensin production	6
cigarette use	6
cov receptor	6
available online	6
mg day	6
descriptive study	6
systemic inflammatory	6
online version	6
following myocardial	6
global pandemic	6
theromyzon tessulatum	6
intestinal absorption	6
sympathetic activity	6
increased blood	6
cerebral amyloid	6
epidemiological studies	6
reactive center	6
functional roles	6
av node	6
transmembrane potential	6
zinc binding	6
higher affinity	6
ns md	6
nucleic acid	6
often associated	6
hypertensive rat	6
binding channel	6
viral genome	6
unclear whether	6
lv ejection	6
potentiating factors	6
cardiovascular morbidity	6
unpublished data	6
never smokers	6
sudden cardiac	6
guanylate cyclase	6
competitive inhibitor	6
increase susceptibility	6
human beings	6
vasomotor tone	6
hospital setting	6
bradykinin levels	6
viral pneumonia	6
systemic hypertension	6
higher rates	6
male mice	6
reproduction number	6
pressure effects	6
virus transmission	6
international committee	6
average age	6
human angiotensinogen	6
inhibitor omapatrilat	6
reactive site	6
multivariate analysis	6
diabetic animals	6
original sars	6
tau pathology	6
share sequence	6
clinical evidence	6
carboxypeptidase activity	6
soluble fraction	6
tissue samples	6
renal damage	6
cytokine production	6
drugs may	6
disease susceptibility	6
giving rise	6
national institute	6
existing hypertension	6
therapy program	6
scientific evidence	6
since ace	6
among others	6
systemic circulation	6
cystic ovaries	6
dd polymorphism	6
leech theromyzon	6
trend towards	6
regulate ace	6
repurposed drugs	6
analysis showed	6
zinc metallopeptidase	6
severe pneumonia	6
may vary	6
inflammatory drugs	6
serpin function	6
inflammatory pathways	6
deceased patients	6
av nodal	6
septal perforators	6
releasing peptide	6
convert ang	6
wet market	6
consecutive patients	6
respiratory infection	6
within days	6
organ dysfunction	6
two catalytic	6
basal level	6
cardiac ischemia	6
proprotein convertases	6
adenylate cyclase	6
rat models	6
may provoke	6
combination therapy	6
left anterior	6
spectrum antiviral	6
expert group	6
aventis behring	6
degradation products	6
frequently used	6
prion protein	6
binding properties	6
may produce	6
aged years	6
neurogenic hypertension	6
randomised controlled	6
potentiating factor	6
tissue plasminogen	6
spontaneous diastolic	6
asymptomatic individuals	6
kinin peptide	6
cellular protease	6
early studies	6
ii angiotensin	6
great deal	6
anterior descending	6
hypotensive effects	6
vascular bed	6
regulates ace	6
virus validation	6
plasma ang	6
neutrophil elastase	6
apoptotic cells	6
negative inotropy	6
remote work	6
putative receptor	6
hydrophobic interactions	6
hospitalised covid	6
shr kidney	6
reduced mortality	6
genetic analysis	6
ventricular ejection	6
ad compared	6
validation studies	6
docking score	6
become infected	6
metabolic disorders	6
underlying conditions	6
emerging evidence	6
lower blood	6
proxy measure	6
two ace	6
selective ace	6
systematic reviews	6
chronic liver	6
future studies	6
patients developed	6
force field	6
vascular complications	6
common symptoms	6
pulmonic valve	6
cysteine residues	6
serum potassium	6
sympathetic activation	6
septum primum	6
free periods	6
activation via	6
locusta migratoria	6
activity levels	6
alkaline phosphatase	6
human kidney	6
ii via	6
gene knockout	6
renovascular hypertension	6
target proteases	6
inactivation pathways	6
culture medium	6
estrogen replacement	6
severe aortic	6
sequence similarity	6
elevated ace	6
adjusted odds	6
significantly elevated	6
clinical parameters	6
correct diagnosis	6
supporting information	6
tentative sars	6
intracellular signaling	6
beneficial role	6
structures reveal	6
using different	6
radial immunodiffusion	6
high doses	6
women taking	6
melanogaster ance	6
current situation	6
lisinopril complex	6
release syndrome	6
ii hereditary	6
randomized trials	6
type calcium	6
inh mutants	6
previously described	6
vivo models	6
supportive care	6
porphyromonas gingivalis	6
sympathetic tone	6
male gender	6
initial docking	6
anopheles stephensi	6
cell activation	6
randomized control	6
mediated vasodilation	6
biochemical characterization	6
hoc analysis	6
without eliciting	6
patients received	6
inh autoantibodies	6
renal expression	6
adjusted hrs	6
charge distribution	6
emergency department	6
physiological roles	6
anoace homologues	6
specific primers	6
dilated cardiomyopathy	6
many tissues	6
docking pose	6
genetic variants	6
may indicate	6
previously shown	6
dimensional structure	6
linked glycosylation	6
respiratory infections	6
severe attacks	6
class ic	6
platelet activation	6
kell blood	6
secondary prevention	6
first evidence	6
western blot	6
johns hopkins	6
central role	6
lower mortality	6
ace homologs	6
expression within	6
antihypertensive efficacy	6
ras inhibitors	6
inverse relationship	6
studies also	6
may exert	6
peptide formation	6
ii also	6
site residues	6
endothelin system	6
renal tissue	6
pulmonary neuroendocrine	6
artery stenosis	6
angioedema due	6
catalytic efficiency	6
platelet aggregation	6
high incidence	5
respiratory virus	5
pulmonary injury	5
thromboembolic events	5
related disorders	5
aldosterone production	5
decompensated heart	5
tmprss protease	5
note springer	5
patients presented	5
also increase	5
antithrombotic effect	5
increased glomerular	5
kidney failure	5
ace imbalance	5
month intervals	5
major mediator	5
irritans exigua	5
serum ang	5
mortality risk	5
binding energy	5
acid replacements	5
ii clinical	5
therapy may	5
endogenous ligand	5
oral contraceptives	5
studies reported	5
site zinc	5
medical treatment	5
therapeutic interventions	5
circulating renin	5
jurisdictional claims	5
fluorogenic substrate	5
catalytic mechanism	5
channel blocker	5
chinese patients	5
subcutaneous insulin	5
putative ace	5
people infected	5
potassium levels	5
increased myocardial	5
may potentially	5
comorbid conditions	5
inhibitor design	5
nature remains	5
facilitate viral	5
three different	5
ed admission	5
similar results	5
renal impairment	5
foramen ovale	5
risk individuals	5
thromboembolic disease	5
aii levels	5
potential conflict	5
glucose control	5
extensively studied	5
second wave	5
like syndrome	5
rat intestine	5
inhibition improves	5
carboxypeptidase ace	5
single active	5
tumor growth	5
derived peptides	5
still unclear	5
negative inotropic	5
hae caused	5
bundle branch	5
weight heparin	5
china medical	5
transgenic animals	5
santa cruz	5
african american	5
vascular system	5
rmsd values	5
ii level	5
ancestral ace	5
domain structure	5
cirrhotic patients	5
angioedema without	5
will need	5
noncardiac surgery	5
ligand complexes	5
consensus sequence	5
urinary excretion	5
age years	5
volume overload	5
short periods	5
systemic inflammation	5
novel peptide	5
saudi arabia	5
broad substrate	5
prove beneficial	5
treatment group	5
antibody specific	5
oral ace	5
paralogous gene	5
clinically significant	5
eliciting reflex	5
increased frequency	5
prostate cancer	5
less effective	5
intracellular ca	5
media thickness	5
ischaemic stroke	5
estrogen therapy	5
recent reports	5
relatively high	5
care alone	5
agt gene	5
study reported	5
bending motion	5
albumin excretion	5
another report	5
inhibitor use	5
alveolar damage	5
ethnic group	5
also suggest	5
inhibitor angiotensin	5
airway obstruction	5
mechanical trauma	5
extracellular signal	5
analysis based	5
specific expression	5
regulated membrane	5
i receptor	5
hyperoxic lung	5
positive disease	5
entry receptor	5
ventricular fibrillation	5
immunity threshold	5
serial interval	5
nep inhibitors	5
interatrial septum	5
ace inhibitory	5
neutrophil infiltration	5
also revealed	5
deficiency angioedema	5
respiratory symptoms	5
inflammatory lung	5
springer nature	5
pressure response	5
denotes covid	5
lockdown levels	5
cdna encoding	5
cord blood	5
plant food	5
novel activity	5
stimulated gene	5
cho cells	5
drug repurposing	5
without ace	5
primary endpoint	5
slightly higher	5
confidence intervals	5
published maps	5
membrane anchor	5
heart rhythm	5
coronary revascularization	5
block sars	5
viral invasion	5
structural features	5
ii trial	5
severe respiratory	5
juxtaglomerular apparatus	5
effective therapeutic	5
pcr positive	5
nonpeptide agonist	5
acute kidney	5
care workers	5
different clinical	5
willebrand factor	5
may worsen	5
mcg kg	5
cl protease	5
selective inhibition	5
new angiotensin	5
vivo substrates	5
reduce mortality	5
wing discs	5
stranded rna	5
also acts	5
study investigators	5
antiviral response	5
kidney angiotensin	5
allele frequency	5
drugs targeting	5
multicenter study	5
neurodegenerative diseases	5
alternative pathways	5
kidney damage	5
angiotensin blockade	5
reverse transcriptase	5
care units	5
ethics committee	5
diagnostic tool	5
population reaches	5
reperfusion injury	5
chloride dependence	5
may induce	5
current study	5
severe exacerbation	5
effects via	5
ace pathways	5
hepatic metabolism	5
symptom onset	5
put forward	5
hypertensive drugs	5
inflammatory properties	5
might provide	5
system also	5
portal hypertensive	5
small intestinal	5
even higher	5
physiological conditions	5
higher susceptibility	5
heparin octasaccharide	5
worse prognosis	5
key modulator	5
liver function	5
therapeutic agents	5
ace differentially	5
viral testing	5
neurotransmitter release	5
experimental lung	5
sars epidemic	5
clinical effect	5
heart attack	5
significant change	5
aldosterone antagonists	5
closely resembles	5
left coronary	5
mutation database	5
cytokine storms	5
ance expression	5
angioedema hereditary	5
electronic health	5
table vi	5
cardiac pacemaker	5
ambulatory blood	5
mononuclear cells	5
congestive cardiac	5
edged sword	5
components required	5
dependent pathway	5
coronavirus diseases	5
best binding	5
closely related	5
domain selective	5
two years	5
new type	5
recent advances	5
heart block	5
developing angioedema	5
limited information	5
clinical significance	5
coronavirus replication	5
recombinant xcace	5
angiotensin aldosterone	5
apical surface	5
effective dose	5
amersham bioscience	5
heart angiotensin	5
soluble angiotensin	5
domain angiotensin	5
kinin receptors	5
pneumonia associated	5
fetal human	5
black bars	5
mesenchymal cells	5
rat rptcs	5
several reports	5
including ace	5
higher plasma	5
data indicate	5
induced oxidative	5
tissue renin	5
male reproductive	5
vasodilatory effect	5
term therapy	5
healthy subjects	5
future treatment	5
diffuse alveolar	5
active angiotensin	5
angioedema symptoms	5
may therefore	5
interquartile range	5
increased covid	5
chronic renal	5
also include	5
positive correlation	5
different types	5
rna virus	5
ace variants	5
oral administration	5
peptide ac	5
containing mm	5
bile duct	5
direct myocardial	5
viral protein	5
entry replication	5
myocardial dysfunction	5
target organ	5
one may	5
multiple biological	5
two alternate	5
elevated ang	5
pattern recognition	5
cell damage	5
may act	5
type iv	5
ras plays	5
fluid homeostasis	5
egg binding	5
likely results	5
receptors mediate	5
studies reporting	5
human small	5
age groups	5
lower airways	5
kininase i	5
tested positive	5
acid glycosides	5
healthcare workers	5
experimental study	5
like immunoreactivity	5
axis may	5
patients whose	5
polymorphism may	5
severely ill	5
main effector	5
improve outcomes	5
genetic polymorphism	5
reflex sympathetic	5
increased renal	5
molecule inhibitors	5
extracellular space	5
length human	5
der waals	5
human serum	5
activity assays	5
expression via	5
antihypertensive treatment	5
cleaves gpi	5
domain form	5
authors report	5
stable angina	5
med doi	5
two different	5
encoding ace	5
markedly increased	5
stellate cells	5
segment elevation	5
protein may	5
small interfering	5
activated factor	5
therapeutic efficacy	5
zona pellucida	5
genomic characterisation	5
escherichia coli	5
also reported	5
patients reported	5
pulmonary damage	5
treatment protocols	5
multiple studies	5
active form	5
serum complement	5
intrinsic rate	5
idiopathic pulmonary	5
raas blockers	5
acidic ph	5
induced endothelial	5
high viral	5
human cell	5
key components	5
water absorption	5
cardiac vein	5
literature review	5
competing interests	5
like gene	5
may reduce	5
body fluids	5
peptide angiotensin	5
significantly different	5
treat hypertension	5
cultured human	5
twice daily	5
prorenin levels	5
rat effect	5
virus infections	5
thrombotic complications	5
association task	5
terminal sequence	5
case rep	5
quinovic acid	5
pathways involving	5
multiple organ	5
institutional affiliations	5
global health	5
circulating coronaviruses	5
receptor mediates	5
controlled randomized	5
cov virus	5
severe complications	5
matrix proteins	5
regulatory role	5
ovarian follicular	5
experimental diabetes	5
human disease	5
zinc metalloproteinase	5
airway disease	5
erythema marginatum	5
critical aminoacids	5
braak tangle	5
ece activity	5
kidney proximal	5
i statistics	5
gene coding	5
change ace	5
test results	5
bradykinin peptides	5
potential benefit	5
oxide production	5
oral submucous	5
blood coagulation	5
ii may	5
will also	5
neuroendocrine cells	5
homologue ance	5
myocardial infarct	5
detrimental effects	5
clinical signs	5
kinetic studies	5
bronchial epithelial	5
may provide	5
infarct size	5
global threat	5
amyloid peptide	5
zinc dependent	5
highly similar	5
great interest	5
clinical condition	5
highly specific	5
study provided	5
forming enzymes	5
counts per	5
glass opacities	5
short duration	5
viral respiratory	5
virus origins	5
lacking angiotensin	5
edematous swelling	5
submucous fibrosis	5
obese diabetic	5
cellular responses	5
lactate dehydrogenase	5
regulate blood	5
via angiotensin	5
extracellular fluid	5
mediated reduction	5
control animals	5
recent findings	5