bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
patients will	155
informed consent	154
data will	144
mechanical ventilation	143
sample size	140
adverse events	139
study will	138
controlled trial	128
control group	111
clinical trial	110
acute respiratory	110
will also	106
will receive	101
additional file	97
study protocol	94
lung injury	91
primary outcome	89
respiratory distress	87
adverse event	85
participants will	84
randomized controlled	82
intensive care	81
clinical trials	81
trial will	80
distress syndrome	77
full protocol	76
group will	75
study intervention	75
data collection	74
ethics committee	72
mg kg	70
analyses will	70
critically ill	69
exclusion criteria	69
respiratory failure	68
study drug	64
within days	63
serious adverse	61
will include	61
analysis will	61
clinical practice	58
randomised controlled	58
trial registration	58
ill patients	57
primary endpoint	57
samples will	57
acute lung	56
secondary outcomes	55
blood pressure	54
inclusion criteria	51
twice daily	50
statistical analysis	50
consent form	48
clinical study	47
systematic review	46
care unit	46
treatment group	44
investigator will	44
ravulizumab bsc	44
pao fio	44
cord uid	42
doc id	42
trials doi	42
pilot rct	42
interim analysis	42
principal investigator	42
protocol amendment	41
two groups	40
icu patients	39
organ failure	39
intervention group	38
consent will	37
risk factors	37
trial design	37
case report	37
public health	37
study team	37
data protection	36
breast cancer	36
chronic obstructive	36
will use	36
pulmonary disease	36
investigators will	36
critical care	36
study center	36
outcomes will	35
invasive mechanical	35
lung function	35
analysis plan	35
clinical improvement	35
patients randomized	35
indigenous infants	34
airway pressure	34
within hours	34
obstructive pulmonary	34
will provide	34
randomization will	34
medical records	32
will take	32
steering committee	32
air pollution	31
respiratory syndrome	31
severe acute	31
dornase alfa	31
dans le	31
protocol version	31
information will	30
missing data	30
first days	30
bsc alone	30
blood gas	30
venous thromboembolism	30
clinical research	30
study design	29
hospitalized patients	29
least one	29
supplemental oxygen	29
icu admission	29
severe covid	28
institutional affiliations	28
per year	28
hospital admission	28
oxygen saturation	28
legally acceptable	28
physical activity	28
report form	28
events will	28
springer nature	28
trial date	28
published maps	28
remains neutral	28
jurisdictional claims	28
patients admitted	28
patient will	28
hypoxic respiratory	28
results will	28
nature remains	28
vector control	27
treatment will	27
side effects	27
clinical outcomes	27
arterial blood	27
blood samples	27
study participants	26
study medication	26
coronavirus disease	26
preterm infants	26
le promoteur	26
healthcare workers	26
gum arabic	26
usual care	26
acceptable representative	26
gut microbiota	26
cure rct	26
lopinavir ritonavir	26
day mortality	26
bubonic plague	26
vestibular function	26
study data	26
primary efficacy	26
les patients	25
cytokine storm	25
treatment groups	25
clinical data	25
research team	25
monitoring committee	25
take place	25
treating physician	25
new zealand	25
trauma patients	25
data analysis	25
copd exacerbation	24
acute hypoxic	24
hearing loss	24
study site	24
hospital discharge	24
written informed	24
randomized clinical	23
eligibility criteria	23
mechanically ventilated	23
university hospital	23
nasal cpap	23
study period	23
note springer	23
participating centers	23
medical patients	23
investigator must	23
blood sample	23
competing interests	23
respiratory symptoms	22
logistic regression	22
icu pilot	22
main outcomes	22
secondary endpoints	22
ward pilot	22
trials website	22
expediting dissemination	22
data management	22
respiratory rate	22
ordinal scale	22
letter serves	22
adult patients	22
behaviour change	22
key elements	22
physical examination	22
familiar formatting	22
outcome measures	22
randomly assigned	22
enoxaparin sodium	22
health organization	22
pneumonic plague	22
kfsh rc	21
lung disease	21
site staff	21
eligible patients	21
cohort study	21
size calculation	21
data monitoring	21
good clinical	21
intervention period	21
parallel group	21
supplementary information	21
source data	21
sensorineural hearing	21
asthma exacerbations	21
crf ecrf	21
patients per	21
hiruz ctu	21
live home	21
controlled trials	21
primary analysis	21
free days	21
cytokine release	21
positive end	21
world health	21
clinical studies	21
trial status	21
yes vs	20
patient information	20
study participation	20
inspired oxygen	20
myocardial infarction	20
pregnancy test	20
supportive care	20
mortality rate	20
main trial	20
principal investigators	20
source documents	20
primary outcomes	20
experimental group	20
study physician	20
expiratory pressure	20
infected patients	20
written consent	20
novel coronavirus	20
vital signs	19
oxygen therapy	19
authors declare	19
efficacy outcome	19
gas exchange	19
ketamine infusion	19
intervention will	19
severe pneumonia	19
groups will	19
confidence interval	19
information accompanies	19
performed using	19
clinically significant	19
sodium chloride	19
heart failure	19
variables will	19
complement activation	19
indoor residual	19
standard deviation	19
per group	19
residual spraying	19
function tests	19
traitement par	19
balance main	18
patients aged	18
final manuscript	18
release syndrome	18
study drugs	18
recruitment manoeuvre	18
female patients	18
high risk	18
significance level	18
medical history	18
staff will	18
safety monitoring	18
structured summary	18
study treatment	18
par le	18
heart rate	18
flow nasal	18
sofa score	18
coordinating investigator	18
analyzed using	18
randomized trial	18
causal relationship	18
hypertension control	17
major bleeding	17
screening period	17
untoward medical	17
medicinal product	17
outcome will	17
interim analyses	17
sudden sensorineural	17
budesonide formoterol	17
will occur	17
rank test	17
corresponding author	17
protocol amendments	17
subject will	17
adverse reaction	17
cancer survivors	17
mg ml	17
phase ii	17
type i	17
positive airway	17
auxiliary nurses	17
nasal obstruction	17
cystic fibrosis	17
personal data	16
monitoring board	16
electronic data	16
statistical methods	16
research ethics	16
patients may	16
patients enrolled	16
icu stay	16
dans les	16
arm will	16
effect size	16
clavulanic acid	16
respiratory tract	16
study procedures	16
will continue	16
medical management	16
ventilated patients	16
medical occurrence	16
severe hypoxaemia	16
may also	16
respiratory illness	16
renal function	16
standard protocol	16
control arm	16
information sheet	16
primary evaluation	16
day will	16
clinically relevant	16
surgical intervention	16
invasive ventilation	16
first patient	16
subjects will	15
primary care	15
ketamine will	15
continuous variables	15
recruitment rate	15
proportional hazards	15
data collected	15
active group	15
irb iec	15
red blood	15
laboratory tests	15
severe respiratory	15
vestibular dysfunction	15
saes will	15
criteria will	15
epithelial cells	15
safety profile	15
local regulations	15
blood cells	15
adverse effects	15
ctcae ratings	15
confirmed covid	15
peep levels	15
cause mortality	15
miracle trial	15
medical record	15
categorical variables	15
will follow	15
critical illness	15
time points	15
risk factor	15
regulatory authorities	15
severe trauma	15
process evaluation	15
protocol items	15
continuous positive	15
cox proportional	15
standard treatment	15
blood cell	15
open label	15
protocol deviations	15
le traitement	15
least years	15
concomitant medication	15
controlled ventilation	15
exact test	15
evaluation period	15
made available	15
digital intervention	15
kg day	14
total sample	14
data safety	14
current study	14
authors read	14
failure assessment	14
sensitivity analyses	14
dementia care	14
pilot study	14
caloric test	14
test will	14
plus soc	14
data entry	14
serum samples	14
days will	14
body weight	14
statistical analyses	14
health care	14
xa activity	14
team will	14
systemic glucocorticoids	14
dose ketamine	14
inhaled sargramostim	14
physician will	14
des patients	14
il inhibitors	14
ethical approval	14
specialist cancer	14
pilot trial	14
primary objective	14
standard care	14
hospital visit	14
aedes aegypti	14
model will	14
final version	14
per protocol	14
trial protocol	14
associated pneumonia	14
path trial	14
secondary outcome	14
subgroup analyses	14
cette recherche	14
induced lung	14
sequential organ	14
month follow	14
inflammatory cytokines	14
ml min	14
will assess	13
resource utilization	13
muscle wasting	13
patients ayant	13
reasonable request	13
sargramostim mcg	13
platelet count	13
treatment allocation	13
clinical effectiveness	13
study personnel	13
regulatory requirements	13
site will	13
secondary objectives	13
ambulatory patients	13
care model	13
health posts	13
acute stroke	13
per arm	13
septal surgery	13
kg min	13
trial steering	13
ct scan	13
pour les	13
eudract number	13
intervention arm	13
partial pressure	13
interventional trials	13
allocation ratio	13
study investigators	13
bloodstream infection	13
increased risk	13
antibiotic treatment	13
early intervention	13
body temperature	13
institutional review	13
quality assurance	13
research council	13
treatment duration	13
acute exacerbation	13
hospital stay	13
iv sargramostim	13
infectious diseases	13
per day	13
rescue intervention	13
protection regulation	13
will evaluate	13
zika virus	13
time frame	13
following criteria	13
inflammatory response	13
cluster randomized	13
indigenous children	13
laboratory parameters	13
i error	13
multicomponent intervention	12
berlin definition	12
ethics approval	12
en cas	12
may require	12
outcomes include	12
peking university	12
tests will	12
long term	12
common terminology	12
future use	12
phase iii	12
pulmonary embolism	12
health research	12
day period	12
comes first	12
oxygen supplementation	12
cancer patients	12
outcome data	12
iu kg	12
virus infection	12
health coaching	12
allergic reactions	12
cluster randomised	12
survivorship care	12
peripheral blood	12
mcg ml	12
first hospital	12
compared using	12
controlled study	12
visits will	12
calendar days	12
inflammatory markers	12
ravulizumab will	12
white blood	12
protocol adherence	12
surface area	12
treatment effect	12
review board	12
en charge	12
confirmed cases	12
direct access	12
approximately patients	12
inferiority margin	12
will allow	12
clinical outcome	12
data capture	12
whichever comes	12
control groups	12
adverse reactions	12
will meet	12
respiratory disease	12
participant will	12
study staff	12
intervention strategy	12
university first	12
nursing home	12
rm max	12
body surface	12
pulse oximetry	12
prep group	12
dans un	12
will ensure	12
standard practice	12
consent forms	12
candidate agents	12
dietary quality	12
systemic inflammation	12
patients infected	11
sargramostim affects	11
take part	11
edta blood	11
chez les	11
will conduct	11
body mass	11
pendant jours	11
temporal relationship	11
patients undergoing	11
trial participants	11
general data	11
randomisation will	11
years old	11
procedure will	11
calculated using	11
patients treated	11
cardiovascular disease	11
respiratory support	11
bacterial pathogens	11
descriptive statistics	11
versus days	11
study visit	11
terminology criteria	11
adjunct low	11
treatment period	11
square test	11
medication will	11
will perform	11
birth weight	11
gas analysis	11
ml kg	11
ovid study	11
active surveillance	11
deemed necessary	11
weeks prior	11
replacement therapy	11
healthcare providers	11
research project	11
respiratory system	11
groups using	11
binary outcome	11
within weeks	11
will make	11
health system	11
fibrosis bronchiectasis	11
chronic lung	11
pro data	11
study groups	11
male patients	11
retrograde cholangiopancreatography	11
trial registry	11
baseline data	11
ventilatory support	11
endoscopic retrograde	11
infants hospitalised	11
patients included	11
treating physicians	11
recovery time	11
among patients	11
past months	11
last patient	11
health districts	11
study results	11
chronic respiratory	11
day onwards	11
outcome measure	11
additional days	11
abv illness	11
flow oxygen	11
final follow	11
whole blood	11
respiratory infection	11
lower respiratory	11
prise en	11
clinical recovery	11
medical sciences	11
endpoint will	11
flow rate	11
ethical committee	11
patients experiencing	11
national institute	11
may th	11
coaching sessions	11
hospital records	11
feasibility study	10
investigational product	10
positive pressure	10
ambulatory treatment	10
observational study	10
last infusion	10
master protocol	10
allocation will	10
parameters will	10
childbearing potential	10
group sequential	10
will consist	10
ae sae	10
high flow	10
will submit	10
first patients	10
total number	10
nasal cannula	10
time point	10
attending physician	10
viral infections	10
will undergo	10
mg per	10
des personnes	10
stimulating factor	10
syndrome coronavirus	10
clinical characteristics	10
mass index	10
kg twice	10
secondary analyses	10
viral infection	10
month period	10
northern territory	10
treat analysis	10
safety outcomes	10
statistical code	10
participant recruitment	10
will review	10
study sites	10
final analysis	10
complement system	10
best supportive	10
study outcomes	10
ward patients	10
nasal septum	10
electronic case	10
abv infection	10
study information	10
safety data	10
mg sarilumab	10
data set	10
fondation adolphe	10
competent authority	10
receive standard	10
patient safety	10
treating clinician	10
respiratory viruses	10
patient data	10
filled syringes	10
mitochondrial dna	10
protocol will	10
arterial pressure	10
applicable regulatory	10
two study	10
american society	10
higher peep	10
influenza virus	10
atrial fibrillation	10
nasal oxygen	10
unexpected serious	10
sae reporting	10
taking part	10
baseline characteristics	10
ischemic stroke	10
drug will	10
au cours	10
renal replacement	10
measurements will	10
will improve	10
regression model	10
patients randomised	10
dose lmwh	10
will compare	10
sample will	10
interquartile range	10
chloride injection	10
recruit patients	10
sponsor will	10
schools will	10
day treatment	10
symptomatic abv	10
computed tomography	10
hypertension treatment	10
regression models	10
reported outcomes	10
current treatment	10
reactive protein	10
allocation sequence	10
renal failure	10
ciprofloxacin mg	10
becoming aware	10
randomization stratification	10
abv transmission	10
health behaviours	10
may include	10
stratification factor	10
statistically significant	10
medical research	10
risk assessment	10
will recruit	10
implementation strategies	9
barthel index	9
category ordinal	9
ctcae rating	9
deep sedation	9
family members	9
sufficient time	9
treatment arm	9
accompanying person	9
will remain	9
two arms	9
cause death	9
conventional therapy	9
le groupe	9
respiratory syncytial	9
zealand clinical	9
hpa axis	9
may lead	9
nurses will	9
period will	9
protocol analysis	9
care units	9
bleeding requiring	9
regression will	9
retrospective cohort	9
bronchiectasis exacerbations	9
day compared	9
please see	9
randomised trials	9
investigator may	9
treat principle	9
least weeks	9
reference number	9
commonly used	9
polymerase chain	9
controlled clinical	9
laboratory test	9
kidney function	9
covid patients	9
sartre study	9
first dose	9
trial data	9
mean change	9
national cancer	9
study population	9
clinical course	9
every hours	9
multiple imputation	9
immune response	9
fio ratio	9
every day	9
widely used	9
patients without	9
uz ghent	9
treatment assignment	9
phone call	9
antibiotic therapy	9
blood serum	9
day visit	9
medical care	9
blood tests	9
will report	9
endpoints will	9
continuous infusion	9
medical treatment	9
single iv	9
study eudract	9
health status	9
liver function	9
must also	9
safety information	9
investigational site	9
respiratory exacerbations	9
patients requiring	9
rater reliability	9
respiratory elastance	9
patient recruited	9
bsc will	9
molecular patterns	9
children will	9
molecular weight	9
relevant bleeding	9
days number	9
visit will	9
population will	9
protocol deviation	9
turbinate reduction	9
documents will	9
individual patient	9
reported outcome	9
will reduce	9
chronic cough	9
antiplatelet therapy	9
provide informed	9
delivery room	9
legal representative	9
energy homeostasis	9
highly effective	9
administered intravenously	9
confidence intervals	9
peripheral vestibular	9
report will	9
will collect	9
elderly patients	9
glasgow coma	9
induced thrombocytopenia	9
national institutes	9
immune system	9
clinical decision	9
un traitement	9
hospitalised patients	9
random numbers	9
monitoring plan	9
form will	9
united states	9
thromboembolic complications	9
spo fio	9
vasoplegic shock	9
mg day	9
alexion confidential	9
arterial oxygen	9
severe air	9
pressure ventilation	9
severe ards	9
chain reaction	9
icu units	9
forms will	9
final report	9
gov nct	9
committee will	9
will require	9
based system	9
least days	9
respiratory bacterial	9
age group	9
emory university	9
associated molecular	9
treatment success	9
biological specimens	9
baseline severity	9
one patient	9
main rct	9
analogue scale	9
mechanical ventilatory	9
therapeutic response	9
congenital anomaly	8
treat population	8
peak inspiratory	8
investigational medicinal	8
potential participants	8
drug administration	8
pas totalement	8
health centers	8
weeks post	8
experimental therapy	8
clinical management	8
months prior	8
hazards model	8
original treatment	8
les informations	8
patient recruitment	8
systolic blood	8
data sharing	8
health outcomes	8
daily doses	8
aes will	8
important protocol	8
endotracheal tube	8
sur le	8
intervention groups	8
anticoagulant treatment	8
versus usual	8
current standard	8
additional blood	8
surfactant administration	8
au promoteur	8
envelopes will	8
reasonable possibility	8
saudi arabia	8
general hospital	8
hazard ratio	8
aged years	8
neutrophil extracellular	8
interstitial pneumonia	8
reported within	8
clinical follow	8
every months	8
implementation process	8
qui se	8
concomitant drug	8
screen failure	8
reviewed journals	8
vein thrombosis	8
trial results	8
last days	8
enoxaparin will	8
research center	8
jwby formulas	8
inflammatory processes	8
combination therapy	8
four groups	8
take oral	8
fatality rate	8
treatment guidelines	8
baseline visit	8
requiring invasive	8
severe renal	8
last visit	8
intravenous infusion	8
group assignment	8
research nurse	8
within months	8
study group	8
low birth	8
previous studies	8
weight heparin	8
huashan hospital	8
secondary analysis	8
ris group	8
protocol violations	8
face mask	8
balance rct	8
outcome assessment	8
epidemiological impact	8
respiratory pathogens	8
functional assessment	8
asthma patients	8
acutely ill	8
study participant	8
treatment effects	8
wilcoxon rank	8
end point	8
room air	8
oxygen supplement	8
version number	8
ten days	8
thromboembolic events	8
die within	8
middle east	8
drugs will	8
values will	8
international guidelines	8
study records	8
routine clinical	8
additional information	8
mean difference	8
first year	8
care services	8
innate immune	8
mashhad university	8
third party	8
creatinine clearance	8
normally distributed	8
nasal airway	8
centers will	8
east respiratory	8
score odoratest	8
proactive prophylaxis	8
alternative explanation	8
next exacerbation	8
patients covid	8
pk pd	8
eminent intervention	8
ayant une	8
chloroquine phosphate	8
patients receiving	8
syncytial virus	8
placebo group	8
axillary temperature	8
blood count	8
lung recruitment	8
general anaesthesia	8
avant le	8
day prednisone	8
des lavages	8
international conference	8
may affect	8
peep level	8
fudan university	8
sc injection	8
national health	8
patients suffering	8
local ethics	8
event one	8
test results	8
yucatan state	8
spontaneous breathing	8
iv injection	8
assessment scales	8
block sizes	8
ventilation mode	8
medical condition	8
dsmb will	8
mg ravulizumab	8
nasal patency	8
trial statistician	8
concomitant disease	8
severe adverse	8
inflammatory effect	8
dmc will	8
rheumatoid arthritis	8
alveolar macrophages	8
related quality	8
days alive	8
randomized control	8
data entries	8
cancer nurse	8
information provided	8
room temperature	7
contact person	7
traditional chinese	7
center will	7
confirmed probable	7
sarilumab will	7
visual analogue	7
prior balance	7
pulmonary hypertension	7
study procedure	7
asthma assessment	7
gcp guidelines	7
health services	7
recruitment rates	7
glucocorticoid therapy	7
exacerbations per	7
therefore believe	7
interviews will	7
recruitment will	7
eortc qlq	7
specimens will	7
systemic inflammatory	7
label trial	7
positive sars	7
australian indigenous	7
uncorrected axillary	7
significantly reduced	7
repeated sc	7
data must	7
practice guidelines	7
storage conditions	7
care coordination	7
large number	7
group allocation	7
aerosolized dornase	7
clinically appropriate	7
peep range	7
educational module	7
financial toxicity	7
laboratory results	7
placebo arm	7
china clinical	7
sum test	7
kg body	7
prevent one	7
author details	7
abv cases	7
ae crf	7
versus medical	7
missing values	7
improve survival	7
standard hygiene	7
random number	7
viral load	7
community health	7
nitrogen balance	7
acacia senegal	7
study subjects	7
allocated treatment	7
les investigateurs	7
nasopharyngeal swab	7
methods design	7
vital parameters	7
ordinating investigator	7
selon les	7
extracellular traps	7
registration number	7
primary endpoints	7
clinical worsening	7
known hypersensitivity	7
will help	7
ill medical	7
future research	7
complex interventions	7
assess whether	7
treatment protocol	7
tract infection	7
chlamydia species	7
rank sum	7
study aims	7
two different	7
ng ml	7
icu wards	7
alanine aminotransferase	7
collect peripheral	7
study conduct	7
versus standard	7
elevated il	7
control program	7
medical monitor	7
ctu will	7
ventilation strategy	7
process will	7
block randomization	7
implementation research	7
feasibility outcomes	7
high levels	7
mg orally	7
lung diseases	7
coronavirus infection	7
disease requiring	7
inflammatory parameters	7
hyperinflammatory syndrome	7
serum ferritin	7
intravenous injection	7
patients recruited	7
le cadre	7
ghent university	7
high dose	7
symptomatic vte	7
blood test	7
th day	7
receive placebo	7
animal models	7
conditional recommendation	7
deviated septum	7
ethics committees	7
days prior	7
meningococcal vaccination	7
clinical benefit	7
intervention clinician	7
study duration	7
research nurses	7
liver disease	7
receive either	7
reference group	7
may reduce	7
children aged	7
severe pollution	7
prone positioning	7
multiorgan failure	7
secondary efficacy	7
following variables	7
factors associated	7
per local	7
include patients	7
single mg	7
ravulizumab treatment	7
le protocole	7
oral consent	7
du protocole	7
whenever possible	7
will obtain	7
jun page	7
will determine	7
brain injury	7
records may	7
du traitement	7
gestational age	7
study database	7
partner therapeutics	7
task force	7
per standard	7
evaluation will	7
randomly allocated	7
oral anticoagulants	7
secondary aim	7
funding body	7
recent laboratory	7
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recommended dose	7
enteral nutrition	7
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three times	7
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income countries	7
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competent authorities	7
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per month	7
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le patient	7
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iv twice	6
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nairos trial	6
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sarilumab plus	6
du produit	6
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bushen yiqi	6
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ent hospital	5
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uz gent	5
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jugement principal	5
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ray index	4
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ards according	4
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le test	4
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type ii	4
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table will	4
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experimental treatment	4
direct oral	4
ctcae toxicities	4
following reasons	4
leur sera	4
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third season	4
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clinical chemistry	4
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peep selected	4
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trial completion	4
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icu days	4
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study set	4
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patients du	4
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aes saes	4
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nasal cavity	4
sharing platform	4
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existing condition	4
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randomization procedure	4
time without	4
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blood oxygenation	4
entourez une	4
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antibody titre	4
induced acute	4
positive samples	4
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intervention components	4
acute onset	4
weight adjusted	4
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also shown	4
interquartile ranges	4
restoring lung	4
common respiratory	4
ventilator will	4
ferritin levels	4
injury induced	4
les traitements	4
drug authority	4
based care	4
examination findings	4
fois par	4
received sufficient	4
one study	4
generated random	4
prospective study	4
lung oxygenation	4
outcome assessor	4
high mortality	4
related aes	4
secondary bacterial	4
le virus	4
peep titration	4
receive anakinra	4
active smoker	4
research associates	4
may contribute	4
hospital zurich	4
ordinal score	4
measuring blood	4
respiratory drive	4
systemic cytokine	4
important difference	4
takes place	4
will explore	4
comparisons will	4
early application	4
received research	4
health science	4
ou non	4
des produits	4
investigator site	4
lower peep	4
day visits	4
equivalent cs	4
nasal septoplasty	4