journal-trials-cord


Introduction

This is a Distant Reader "study carrel", a set of structured data intended to help the student, researcher, or scholar use & understand a corpus.

This study carrel was created on 2021-05-30 by Eric Morgan <emorgan@nd.edu>. The carrel was created using the Distant Reader cord process, and the input was the result of a query applied to a local mirror of CORD, a data set of scholarly articles on the topic of COVID-19. The actual query was: facet_journal:"Trials". The results of this query were saved in a cache and transformed into a set of plain text files. All of the analysis -- "reading" -- has been done against these plain text files. For example, a short narrative report has been created. This Web page is a more verbose version of that report.

All study carrels are self-contained -- no Internet connection is necessary to use them. Download this carrel for offline reading. The carrel is made up of many subdirectories and data files. The manifest describes each one in greater detail.

Size

There are 42 item(s) in this carrel, and this carrel is 270,802 words long. Each item in your study carrel is, on average, 6,447 words long. If you dig deeper, then you might want to save yourself some time by reading a shorter item. On the other hand, if your desire is for more detail, then you might consider reading a longer item. The following charts illustrate the overall size of the carrel.

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histogram of sizes
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box plot of sizes

Readability

On a scale from 0 to 100, where 0 is very difficult and 100 is very easy, the documents have an average readability score of 47. Consequently, if you want to read something more simplistic, then consider a document with a higher score. If you want something more specialized, then consider something with a lower score. The following charts illustrate the overall readability of the carrel.

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histogram of readability
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box plot of readability

Word Frequencies

By merely counting & tabulating the frequency of individual words or phrases, you can begin to get an understanding of the carrel's "aboutness". Excluding "stop words", some of the more frequent words include:

will, study, patients, trial, data, treatment, clinical, patient, covid, protocol, day, group, intervention, days, care, analysis, time, may, health, respiratory, hospital, use, primary, participants, using, acute, consent, used, within, medical, also, based, blood, randomized, disease, outcomes, icu, control, information, follow, research, severe, investigator, two, lung, following, non, outcome, risk, number

Using the three most frequent words, the three files containing all of those words the most are A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial, Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial, and Sarilumab versus standard of care for the early treatment of COVID-19 pneumonia in hospitalized patients: SARTRE: a structured summary of a study protocol for a randomised controlled trial.

The most frequent two-word phrases (bigrams) include:

patients will, informed consent, data will, mechanical ventilation, sample size, adverse events, study will, controlled trial, control group, clinical trial, acute respiratory, will also, will receive, additional file, study protocol, lung injury, primary outcome, respiratory distress, adverse event, participants will, randomized controlled, intensive care, clinical trials, trial will, distress syndrome, full protocol, group will, study intervention, data collection, ethics committee, analyses will, mg kg, critically ill, exclusion criteria, respiratory failure, study drug, within days, serious adverse, will include, analysis will, clinical practice, randomised controlled, trial registration, primary endpoint, samples will, ill patients, acute lung, secondary outcomes, blood pressure, inclusion criteria

And the three file that use all of the three most frequent phrases are A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial, and Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial.

While often deemed superficial or sophomoric, rudimentary frequencies and their associated "word clouds" can be quite insightful:

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unigrams
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bigrams

Keywords

Sets of keywords -- statistically significant words -- can be enumerated by comparing the relative frequency of words with the number of times the words appear in an entire corpus. Some of the most statistically significant keywords in the carrel include:

patient, study, covid-19, trial, day, icu, health, ards, sars, respiratory, rct, peep, lmwh, intervention, il-6, exacerbation, yucatan, vte, vestibular, ventilation, treatment, trauma, tirs, test, tcm, subject, stroke, stage, southampton, soc, school, sae, pwd, pro, plague, participant, outcome, nurse, norway, nasal, nairos, muscle, mers, madagascar, line, leukine, les, kfsh&rc, ketamine, issnhl

And now word clouds really begin to shine:

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keywords

Topic Modeling

Topic modeling is another popular approach to connoting the aboutness of a corpus. If the study carrel could be summed up in a single word, then that word might be will, and Nasal Airway Obstruction Study (NAIROS): a phase III, open-label, mixed-methods, multicentre randomised controlled trial of septoplasty versus medical management of a septal deviation with nasal obstruction is most about that word.

If the study carrel could be summed up in three words ("topics") then those words and their significantly associated titles include:

  1. will - The TIRS trial: protocol for a cluster randomized controlled trial assessing the efficacy of preventive targeted indoor residual spraying to reduce Aedes-borne viral illnesses in Merida, Mexico
  2. will - Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial
  3. patients - Efficacy of local budesonide therapy in the management of persistent hyposmia in COVID-19 patients without signs of severity: A structured summary of a study protocol for a randomised controlled trial

If the study carrel could be summed up in five topics, and each topic were each denoted with three words, then those topics and their most significantly associated files would be:

  1. will, trial, study - Engaging adolescents in changing behaviour (EACH-B): a study protocol for a cluster randomised controlled trial to improve dietary quality and physical activity
  2. will, study, patients - Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial
  3. study, patients, will - Efficacy of local budesonide therapy in the management of persistent hyposmia in COVID-19 patients without signs of severity: A structured summary of a study protocol for a randomised controlled trial
  4. will, patients, study - Model-based PEEP titration versus standard practice in mechanical ventilation: a randomised controlled trial
  5. will, trial, intervention - LIVE@Home.Path—innovating the clinical pathway for home-dwelling people with dementia and their caregivers: study protocol for a mixed-method, stepped-wedge, randomized controlled trial

Moreover, the totality of the study carrel's aboutness, can be visualized with the following pie chart:

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topic model

Noun & Verbs

Through an analysis of your study carrel's parts-of-speech, you are able to answer question beyonds aboutness. For example, a list of the most frequent nouns helps you answer what questions; "What is discussed in this collection?":

patients, study, trial, data, treatment, intervention, days, patient, group, protocol, analysis, care, time, day, participants, consent, blood, health, outcomes, information, lung, use, ventilation, risk, outcome, disease, hospital, control, number, infection, test, recruitment, events, safety, randomization, criteria, research, dose, results, investigator, case, therapy, event, pressure, site, period, symptoms, sample, assessment, design

An enumeration of the verbs helps you learn what actions take place in a text or what the things in the text do. Very frequently, the most common lemmatized verbs are "be", "have", and "do"; the more interesting verbs usually occur further down the list of frequencies:

using, include, following, received, provided, based, reported, performed, requiring, compared, controlled, treated, conduct, collected, reduced, taken, assessing, considered, associated, defined, participate, according, give, improving, show, related, evaluate, obtained, randomized, recorded, increased, occur, made, administered, measured, develop, confirmed, identified, recruit, approved, complete, allowed, see, meet, written, present, enrolled, expect, need, described

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nouns
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verbs

Proper Nouns

An extraction of proper nouns helps you determine the names of people and places in your study carrel.

COVID-19, •, ICU, ARDS, Health, SARS, RCT, University, mg, Hospital, Investigator, X, SAE, CoV-2, AE, du, Committee, Clinical, Research, le, COPD, BSC, BALANCE, Alexion, sargramostim, ou, Data, ravulizumab, VTE, National, kg, IL-6, enoxaparin, Table, COVID, au, Trials, Protocol, Day, Medical, Fig, SAEs, GM, Ethics, sera, China, les, azithromycin, TIRS, IV

An analysis of personal pronouns enables you to answer at least two questions: 1) "What, if any, is the overall gender of my study carrel?", and 2) "To what degree are the texts in my study carrel self-centered versus inclusive?"

we, it, their, our, they, its, them, i, his, you, he, she, her, your, us, themselves, my, itself, one, me, mg, him, himself, herself, mrs, aptt, , yn7pu9i8, peep, il-6-sartre, http://www.gnomixx.com/

Below are words cloud of your study carrel's proper & personal pronouns.

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proper nouns
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pronouns

Adjectives & Verbs

Learning about a corpus's adjectives and adverbs helps you answer how questions: "How are things described and how are things done?" An analysis of adjectives and adverbs also points to a corpus's overall sentiment. "In general, is my study carrel positive or negative?"

clinical, respiratory, primary, acute, severe, medical, adverse, non, additional, first, secondary, high, randomized, patient, local, mechanical, positive, standard, available, informed, anti, low, final, specific, statistical, possible, inflammatory, randomised, pulmonary, potential, current, serious, covid-19, significant, appropriate, full, applicable, main, chronic, new, early, key, single, relevant, oral, last, important, critical, invasive, eligible

also, well, however, prior, daily, therefore, critically, least, immediately, currently, clinically, approximately, twice, alone, still, significantly, potentially, randomly, directly, first, highly, regardless, previously, especially, soon, respectively, furthermore, legally, already, specifically, later, additionally, mechanically, fully, recently, even, usually, early, routinely, rather, possibly, orally, separately, often, moreover, widely, together, frequently, yet, otherwise

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adjectives
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adverbs

Next steps

There is much more to a study carrel than the things outlined above. Use this page's menubar to navigate and explore in more detail. There you will find additional features & functions including: ngrams, parts-of-speech, grammars, named entities, topic modeling, a simple search interface, etc.

Again, study carrels are self-contained. Download this carrel for offline viewing and use.

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