This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.
trigram | frequency |
---|---|
the presence of | 486 |
as well as | 419 |
in the presence | 299 |
cd t cells | 251 |
the absence of | 240 |
influenza a virus | 227 |
in the absence | 206 |
hepatitis c virus | 203 |
were infected with | 196 |
of the viral | 196 |
in this study | 188 |
as previously described | 186 |
type i ifn | 182 |
the cells were | 175 |
severe acute respiratory | 174 |
we found that | 173 |
the number of | 170 |
the role of | 168 |
acute respiratory syndrome | 167 |
in order to | 163 |
is required for | 162 |
was used to | 161 |
due to the | 156 |
hek t cells | 152 |
in addition to | 151 |
cells were infected | 147 |
the expression of | 145 |
to determine the | 143 |
a and b | 141 |
analysis of the | 140 |
respiratory syndrome coronavirus | 137 |
according to the | 137 |
been shown to | 136 |
at room temperature | 135 |
based on the | 134 |
for min at | 132 |
vesicular stomatitis virus | 132 |
cd t cell | 131 |
of the virus | 130 |
plos pathog doi | 129 |
t cells were | 126 |
for h at | 125 |
west nile virus | 122 |
in response to | 118 |
cells were transfected | 117 |
to determine whether | 117 |
one of the | 116 |
in contrast to | 116 |
were transfected with | 116 |
the amount of | 114 |
data not shown | 112 |
activation of the | 110 |
structure of the | 109 |
were used to | 108 |
members of the | 108 |
respiratory syncytial virus | 107 |
of type i | 106 |
the induction of | 106 |
in infected cells | 104 |
an moi of | 104 |
was performed using | 104 |
as described previously | 103 |
consistent with the | 103 |
the majority of | 100 |
at an moi | 98 |
the development of | 97 |
was determined by | 97 |
fig a and | 96 |
has been shown | 96 |
compared to the | 96 |
expression of the | 95 |
were incubated with | 95 |
the ability of | 95 |
was added to | 94 |
the plasma membrane | 93 |
cells were incubated | 93 |
a number of | 92 |
the formation of | 90 |
pla g a | 90 |
type i interferon | 90 |
cells infected with | 89 |
as shown in | 89 |
cells were washed | 89 |
the cell surface | 88 |
the effect of | 87 |
a role in | 87 |
b and c | 86 |
each of the | 86 |
the level of | 85 |
observed in the | 85 |
as described above | 85 |
mice infected with | 85 |
at uc for | 84 |
region of the | 84 |
is essential for | 84 |
the importance of | 83 |
involved in the | 83 |
cells were fixed | 83 |
s q y | 83 |
was used as | 81 |
the use of | 80 |
cells in the | 80 |
it has been | 79 |
the fact that | 79 |
the production of | 79 |
well as the | 79 |
end of the | 78 |
data suggest that | 78 |
in vitro and | 78 |
crystal structure of | 78 |
mouse hepatitis virus | 78 |
of influenza a | 78 |
were treated with | 77 |
herpes simplex virus | 76 |
the context of | 76 |
hepatitis b virus | 76 |
mhv h a | 75 |
shown to be | 75 |
we show that | 75 |
it is possible | 74 |
suggesting that the | 73 |
cells were then | 73 |
was observed in | 73 |
western blot analysis | 73 |
associated with the | 72 |
of viral rna | 71 |
the lack of | 71 |
were determined by | 71 |
in the context | 71 |
the case of | 70 |
as described in | 70 |
s and s | 70 |
in the same | 70 |
shown in fig | 69 |
in the case | 69 |
the activation of | 69 |
in the cns | 68 |
to that of | 68 |
the activity of | 68 |
is possible that | 67 |
added to the | 67 |
role in the | 67 |
the effects of | 66 |
the replication of | 66 |
d b np | 66 |
role of the | 65 |
fig b and | 65 |
of the host | 65 |
is consistent with | 65 |
activity of the | 64 |
present in the | 64 |
detected in the | 64 |
is associated with | 64 |
were used for | 64 |
the levels of | 64 |
human immunodeficiency virus | 64 |
innate immune response | 63 |
were obtained from | 63 |
presence of the | 63 |
c and d | 63 |
the end of | 63 |
the evolution of | 63 |
the structure of | 63 |
results indicate that | 62 |
d b npn | 62 |
kindly provided by | 62 |
responsible for the | 62 |
total rna was | 62 |
these data suggest | 62 |
s b fig | 62 |
influenza a viruses | 61 |
of infected cells | 61 |
resulted in a | 60 |
h n influenza | 60 |
by flow cytometry | 60 |
the possibility that | 60 |
by plaque assay | 60 |
an increase in | 60 |
in cell culture | 60 |
suggest that the | 60 |
the emergence of | 60 |
the release of | 60 |
high levels of | 59 |
b npn a | 59 |
h at uc | 59 |
production of infectious | 59 |
changes in the | 58 |
and s fig | 58 |
s a fig | 58 |
showed that the | 58 |
were performed in | 58 |
was used for | 58 |
as compared to | 58 |
dependent rna polymerase | 58 |
by western blot | 57 |
t cells in | 57 |
ns and ns | 57 |
middle east respiratory | 57 |
contribute to the | 57 |
of influenza virus | 57 |
viral rna synthesis | 57 |
and characterization of | 56 |
v p y | 56 |
found that the | 56 |
a total of | 56 |
indicating that the | 56 |
were incubated for | 56 |
of the two | 56 |
the viral rna | 55 |
required for the | 55 |
mutations in the | 55 |
similar to the | 55 |
cell lysates were | 55 |
appears to be | 55 |
infection in the | 55 |
p y f | 55 |
three independent experiments | 55 |
to determine if | 54 |
east respiratory syndrome | 54 |
viral gene expression | 54 |
used as a | 54 |
have been shown | 54 |
as a result | 54 |
were maintained in | 54 |
the addition of | 54 |
the control of | 54 |
the mechanism of | 54 |
the university of | 54 |
derived from the | 53 |
the viral genome | 53 |
wild type and | 53 |
the extent of | 53 |
p and p | 53 |
a role for | 53 |
of hepatitis c | 53 |
was carried out | 53 |
virus infection in | 52 |
found to be | 52 |
such as the | 52 |
is involved in | 52 |
central nervous system | 52 |
ha and na | 52 |
part of the | 52 |
cells were lysed | 52 |
in agreement with | 52 |
to this end | 51 |
was detected in | 51 |
in comparison to | 51 |
analysis was performed | 51 |
remains to be | 51 |
be involved in | 51 |
rlr signaling proteins | 51 |
the interaction between | 51 |
referred to as | 51 |
has been reported | 51 |
sialic acid binding | 50 |
at h post | 50 |
the host cell | 50 |
or absence of | 50 |
of cd t | 50 |
presence or absence | 50 |
the presence or | 50 |
it is not | 50 |
in a cells | 50 |
of the human | 50 |
in the cytoplasm | 50 |
balb c mice | 50 |
were purchased from | 49 |
on the other | 49 |
infected with the | 49 |
materials and methods | 49 |
we observed a | 49 |
a a a | 49 |
relative to the | 49 |
in the viral | 49 |
are shown in | 49 |
ev c atpase | 49 |
h n virus | 49 |
cells were treated | 49 |
in human cells | 49 |
indicate that the | 48 |
characterization of the | 48 |
the identification of | 48 |
was performed as | 48 |
to assess the | 48 |
vitro and in | 48 |
of viral replication | 48 |
virus replication and | 48 |
fig c and | 48 |
were incubated at | 48 |
hmpv f protein | 48 |
in complex with | 48 |
to wild type | 47 |
the impact of | 47 |
and cells were | 47 |
the endoplasmic reticulum | 47 |
atrh and atrh | 47 |
an important role | 47 |
innate immune responses | 47 |
a result of | 47 |
presence of a | 47 |
of severe acute | 46 |
a variety of | 46 |
replication in the | 46 |
and in vivo | 46 |
found in the | 46 |
of vesicular stomatitis | 46 |
as determined by | 46 |
of c atpase | 46 |
results suggest that | 46 |
been reported to | 46 |
of three independent | 46 |
is dependent on | 46 |
of the n | 46 |
with pfu of | 46 |
the interaction of | 46 |
of a novel | 46 |
on the cell | 46 |
the course of | 46 |
the binding of | 45 |
for minutes at | 45 |
show that the | 45 |
and incubated for | 45 |
we demonstrate that | 45 |
most of the | 45 |
of the ifn | 45 |
that of the | 45 |
have been reported | 45 |
increase in the | 45 |
compared to wild | 45 |
all of the | 45 |
incubated at uc | 45 |
of the p | 45 |
and in the | 45 |
the d b | 45 |
we conclude that | 44 |
r interaction sites | 44 |
was able to | 44 |
of l pro | 44 |
when compared to | 44 |
the ability to | 44 |
fig and s | 44 |
nile virus infection | 43 |
at the indicated | 43 |
the generation of | 43 |
data indicate that | 43 |
play a role | 43 |
demonstrate that the | 43 |
was found to | 43 |
were analyzed by | 43 |
the percentage of | 43 |
the hmpv f | 43 |
the inhibition of | 43 |
washed twice with | 43 |
regions of the | 43 |
unfolded protein response | 43 |
the other hand | 43 |
this suggests that | 43 |
figure s a | 43 |
have shown that | 43 |
with the exception | 42 |
the type i | 42 |
to interact with | 42 |
likely to be | 42 |
the accumulation of | 42 |
care and use | 42 |
r interaction site | 42 |
hela cells were | 42 |
of rna viruses | 42 |
cells were seeded | 42 |
activated protein kinase | 42 |
similar to that | 42 |
during wnv infection | 41 |
in the lungs | 41 |
and stained with | 41 |
in cells infected | 41 |
were observed in | 41 |
multiplicity of infection | 41 |
was removed and | 41 |
in the brain | 41 |
corresponding to the | 41 |
rna was extracted | 41 |
cells treated with | 41 |
rna was isolated | 41 |
of rnase l | 41 |
shown in figure | 41 |
a range of | 41 |
it is also | 41 |
compared to wt | 41 |
the innate immune | 41 |
the coiled coil | 41 |
these results indicate | 41 |
with ml of | 41 |
were used as | 41 |
have been described | 41 |
type i ifns | 41 |
is mediated by | 40 |
replication of the | 40 |
were added to | 40 |
were inoculated with | 40 |
after infection with | 40 |
its ability to | 40 |
understanding of the | 40 |
in the lung | 40 |
and incubated with | 40 |
min at uc | 40 |
was performed in | 40 |
viral replication and | 40 |
at the same | 40 |
the frequency of | 40 |
of the cell | 40 |
were grown in | 40 |
it is likely | 40 |
used for the | 40 |
were detected in | 40 |
cells were harvested | 40 |
of ded p | 40 |
strand rna synthesis | 40 |
final concentration of | 40 |
of the protein | 40 |
was shown to | 40 |
is able to | 40 |
used in this | 39 |
t cell responses | 39 |
was measured by | 39 |
was associated with | 39 |
were stained with | 39 |
were collected at | 39 |
to the cell | 39 |
semliki forest virus | 39 |
of the c | 39 |
between the two | 39 |
of the upr | 39 |
has not been | 39 |
are essential for | 39 |
were carried out | 39 |
be due to | 39 |
of the rna | 39 |
are required for | 39 |
of sindbis virus | 39 |
position of the | 39 |
to be a | 39 |
the exception of | 39 |
of the most | 39 |
closely related to | 38 |
wild type mice | 38 |
the regulation of | 38 |
a subset of | 38 |
function of the | 38 |
specific cd t | 38 |
our understanding of | 38 |
incubated for h | 38 |
did not affect | 38 |
type i and | 38 |
virus replication in | 38 |
we hypothesized that | 38 |
some of the | 38 |
with or without | 38 |
in the nucleus | 38 |
used to determine | 38 |
at uc in | 38 |
is responsible for | 37 |
the surface of | 37 |
infected cells were | 37 |
provided by dr | 37 |
are involved in | 37 |
fetal bovine serum | 37 |
viral replication in | 37 |
member of the | 37 |
in mammalian cells | 37 |
in ml of | 37 |
viral rna was | 37 |
a critical role | 37 |
in fig a | 37 |
the tombusvirus replicase | 37 |
supernatants were collected | 37 |
the h n | 37 |
venezuelan equine encephalitis | 37 |
experiments were performed | 37 |
and stored at | 37 |
is known to | 37 |
there was no | 37 |
of h n | 37 |
of infectious virus | 36 |
and analyzed by | 36 |
has also been | 36 |
for min and | 36 |
were resuspended in | 36 |
that can be | 36 |
binding to the | 36 |
but not in | 36 |
of these viruses | 36 |
the central nervous | 36 |
were generated by | 36 |
for detection of | 36 |
t cell response | 36 |
suggests that the | 36 |
in terms of | 36 |
mice were infected | 36 |
the site of | 36 |
of the sars | 36 |
immunodeficiency virus type | 36 |
contributes to the | 36 |
the function of | 36 |
is shown in | 36 |
the crystal structure | 36 |
performed as described | 35 |
due to a | 35 |
sequences of the | 35 |
in which the | 35 |
as a control | 35 |
are representative of | 35 |
these data indicate | 35 |
was performed on | 35 |
the efficiency of | 35 |
a final concentration | 35 |
lymphocytic choriomeningitis virus | 35 |
important role in | 35 |
by using the | 35 |
the ppxy motif | 35 |
rna replication and | 35 |
are known to | 35 |
of the genome | 35 |
plays a role | 35 |
npn a cd | 35 |
dependent on the | 35 |
characterization of a | 35 |
mediated by the | 35 |
identification of a | 35 |
were washed twice | 35 |
residues in the | 35 |
of ebov gp | 35 |
d and e | 35 |
the proportion of | 35 |
of the three | 35 |
we used a | 34 |
induction of the | 34 |
cells transfected with | 34 |
regulation of the | 34 |
at h p | 34 |
crystal structures of | 34 |
in wt mice | 34 |
the loss of | 34 |
by centrifugation at | 34 |
from the same | 34 |
is important for | 34 |
at the end | 34 |
the assembly of | 34 |
to identify the | 34 |
of the s | 34 |
the severe acute | 34 |
contrast to the | 34 |
related to the | 34 |
is likely that | 34 |
stability of the | 34 |
in the liver | 34 |
induction of ifn | 34 |
in both the | 34 |
by using a | 34 |
the observation that | 34 |
at day p | 34 |
component of the | 34 |
of rlr signaling | 34 |
the unfolded protein | 33 |
uc for min | 33 |
cells were maintained | 33 |
followed by a | 33 |
may be a | 33 |
we did not | 33 |
in line with | 33 |
following reovirus infection | 33 |
the detection of | 33 |
in the human | 33 |
open reading frame | 33 |
to investigate the | 33 |
of pla g | 33 |
were collected and | 33 |
have not been | 33 |
the distribution of | 33 |
we used the | 33 |
equine encephalitis virus | 33 |
required for efficient | 33 |
the ratio of | 33 |
for viral replication | 33 |
for at least | 33 |
in s table | 33 |
to be the | 33 |
of west nile | 33 |
amino acid sequence | 33 |
inhibition of the | 33 |
not required for | 33 |
low levels of | 33 |
results demonstrate that | 33 |
figure b and | 33 |
simplex virus type | 33 |
the viral replication | 33 |
not due to | 33 |
of protein vi | 33 |
expression of a | 33 |
was performed with | 33 |
wide range of | 33 |
has been demonstrated | 33 |
mutation in the | 32 |
viral and host | 32 |
bind to the | 32 |
are likely to | 32 |
could not be | 32 |
was purchased from | 32 |
to study the | 32 |
downstream of the | 32 |
gene expression in | 32 |
assays were performed | 32 |
min at room | 32 |
after h of | 32 |
infected cells and | 32 |
in hela cells | 32 |
in the s | 32 |
is likely to | 32 |
figure s b | 32 |
room temperature for | 32 |
components of the | 32 |
results in a | 32 |
there was a | 32 |
type i interferons | 32 |
of the influenza | 32 |
washed with pbs | 32 |
a wide range | 32 |
the pathogenesis of | 32 |
the lungs of | 32 |
with the viral | 31 |
mechanism by which | 31 |
there is no | 31 |
vero e cells | 31 |
these results suggest | 31 |
was incubated with | 31 |
with pbs and | 31 |
the time of | 31 |
of ebola virus | 31 |
and resuspended in | 31 |
performed as previously | 31 |
were washed with | 31 |
mm tris ph | 31 |
approved by the | 31 |
mapk erk pathway | 31 |
of viral proteins | 31 |
d b v | 31 |
in combination with | 31 |
of the h | 31 |
two independent experiments | 31 |
a decrease in | 31 |
were subjected to | 31 |
gene expression and | 31 |
total number of | 31 |
binding of the | 31 |
b v p | 31 |
was determined using | 30 |
and the viral | 30 |
strand rna viruses | 30 |
s c fig | 30 |
is the first | 30 |
led to a | 30 |
determine whether the | 30 |
results show that | 30 |
differences in the | 30 |
knockdown of vcp | 30 |
in vitro transcribed | 30 |
to be involved | 30 |
a and c | 30 |
been associated with | 30 |
as a negative | 30 |
was performed by | 30 |
of virus replication | 30 |
hmpv b f | 30 |
titers in the | 30 |
murine hepatitis virus | 30 |
and transferred to | 30 |
the stability of | 30 |
uc for h | 30 |
we observed that | 30 |
interaction with the | 30 |
subclinical in utero | 30 |
and activation of | 30 |
interaction site mutants | 30 |
the total number | 30 |
were harvested at | 30 |
coronavirus spike protein | 30 |
infected with mhv | 30 |
cd and cd | 30 |
the secretory pathway | 30 |
the influenza virus | 30 |
none of the | 30 |
terminal domain of | 30 |
the supernatant was | 30 |
and that the | 30 |
the synthesis of | 30 |
the same time | 30 |
were performed as | 30 |
with respect to | 29 |
any of the | 29 |
titers were determined | 29 |
a reduction in | 29 |
a consequence of | 29 |
the influenza a | 29 |
determined by the | 29 |
for h with | 29 |
data demonstrate that | 29 |
was also observed | 29 |
we also observed | 29 |
plasmacytoid dendritic cells | 29 |
were found to | 29 |
at least three | 29 |
of hepatitis b | 29 |
a cells were | 29 |
a functional sbs | 29 |
insights into the | 29 |
were transferred to | 29 |
were fixed and | 29 |
pcr products were | 29 |
have been identified | 29 |
of the receptor | 29 |
specificity of the | 29 |
ded p is | 29 |
for h and | 29 |
can be used | 29 |
in virus replication | 29 |
of a single | 29 |
domain of the | 29 |
washed three times | 29 |
of prp sc | 29 |
the p p | 29 |
was quantified by | 29 |
indicated by the | 29 |
described in the | 29 |
many of the | 29 |
binds to the | 29 |
role for the | 29 |
it should be | 29 |
viral titers in | 29 |
to examine the | 29 |
consistent with our | 29 |
in the cell | 29 |
the host response | 29 |
were fixed with | 29 |
used to generate | 29 |
we propose that | 29 |
we have previously | 29 |
the virus to | 28 |
included in the | 28 |
at the time | 28 |
identified in the | 28 |
plates were incubated | 28 |
to generate a | 28 |
is critical for | 28 |
well plates were | 28 |
that in the | 28 |
and cd t | 28 |
a series of | 28 |
by addition of | 28 |
of the spike | 28 |
the immune response | 28 |
ie and ie | 28 |
h n viruses | 28 |
used in the | 28 |
were seeded in | 28 |
viral rna replication | 28 |
demonstrated that the | 28 |
were normalized to | 28 |
identification of the | 28 |
b and s | 28 |
we determined the | 28 |
obtained from the | 28 |
mutation of the | 28 |
animal care and | 28 |
was isolated from | 28 |
of mouse hepatitis | 28 |
assembly of the | 28 |
of the sbs | 28 |
sequence of the | 28 |
there is a | 28 |
to note that | 28 |
results showed that | 28 |
in accordance with | 28 |
b and d | 28 |
compared with the | 28 |
the fraction of | 28 |
immune response to | 28 |
the immune system | 28 |
of wild type | 28 |
expression levels of | 28 |
is due to | 28 |
of the cells | 28 |
t cells and | 28 |
supplemented with fetal | 27 |
of the a | 27 |
insight into the | 27 |
to the host | 27 |
in mosquito cells | 27 |
levels of viral | 27 |
the length of | 27 |
prior to the | 27 |
c virus infection | 27 |
to test this | 27 |
than that of | 27 |
to be determined | 27 |
resulting in a | 27 |
located in the | 27 |
virus rna replication | 27 |
the reassortant viruses | 27 |
processing of the | 27 |
consistent with previous | 27 |
at least two | 27 |
were collected from | 27 |
leading to the | 27 |
of virus particles | 27 |
interacts with the | 27 |
known to be | 27 |
was replaced with | 27 |
assay was performed | 27 |
is not known | 27 |
in the virus | 27 |
appeared to be | 27 |
carried out using | 27 |
alb ts and | 27 |
the brains of | 27 |
were able to | 27 |
in these cells | 27 |
as measured by | 27 |
viral genomic rna | 27 |
effect on the | 27 |
to the nucleus | 27 |
in pbs and | 27 |
acid binding site | 27 |
open reading frames | 27 |
indicated that the | 27 |
mhc class i | 27 |
data show that | 27 |
the n module | 27 |
the existence of | 27 |
a significant increase | 27 |
an essential role | 27 |
the dynamics of | 27 |
led to the | 27 |
the wild type | 27 |
structural and functional | 27 |
were performed using | 27 |
expression in the | 27 |
revealed that the | 27 |
m and m | 27 |
fig d and | 27 |
cells were inoculated | 26 |
consistent with a | 26 |
in viral replication | 26 |
been implicated in | 26 |
carried out in | 26 |
at uc and | 26 |
in the first | 26 |
well as in | 26 |
the most abundant | 26 |
a negative control | 26 |
interact with the | 26 |
that ded p | 26 |
been shown that | 26 |
i ifn production | 26 |
virus infection and | 26 |
structures of the | 26 |
viruses in the | 26 |
cells were grown | 26 |
in the host | 26 |
virus and host | 26 |
in c cells | 26 |
are important for | 26 |
fatty acid synthesis | 26 |
significant increase in | 26 |
the analysis of | 26 |
importance of the | 26 |
g for min | 26 |
in the two | 26 |
are listed in | 26 |
not affect the | 26 |
bushy stunt virus | 26 |
significant reduction in | 26 |
protein and the | 26 |
and incubated at | 26 |
at the plasma | 26 |
the virus and | 26 |
was confirmed by | 26 |
a mouse model | 26 |
we suggest that | 26 |
interferon regulatory factor | 26 |
the contribution of | 26 |
their ability to | 26 |
similar results were | 26 |
agreement with the | 26 |
are associated with | 26 |
appear to be | 26 |
determined by plaque | 26 |
of the total | 26 |
serve as a | 26 |
at least in | 26 |
tomato bushy stunt | 26 |
the in vitro | 26 |
would like to | 26 |
that there is | 26 |
may contribute to | 26 |
that have been | 26 |
to the viral | 26 |
in figure a | 26 |
by confocal microscopy | 26 |
no effect on | 26 |
reduction in the | 26 |
a and s | 25 |
recognition of the | 25 |
h post infection | 25 |
the npn a | 25 |
in a humidified | 25 |
a virus infection | 25 |
h post transfection | 25 |
b np cd | 25 |
nature of the | 25 |
addition to the | 25 |
a fraction of | 25 |
induction of type | 25 |
the hypothesis that | 25 |
for the virus | 25 |
the infected cells | 25 |
depending on the | 25 |
prior to infection | 25 |
influenza virus infection | 25 |
be used to | 25 |
followed by the | 25 |
were analyzed using | 25 |
interaction between the | 25 |
the recruitment of | 25 |
as a consequence | 25 |
like to thank | 25 |
may not be | 25 |
a multiplicity of | 25 |
it is important | 25 |
ability of the | 25 |
to those of | 25 |
the requirement for | 25 |
incubated for min | 25 |
wt and ifit | 25 |
explained by the | 25 |
cells that were | 25 |
fold increase in | 25 |
these results demonstrate | 25 |
u os cells | 25 |
were harvested and | 25 |
a gift from | 25 |
the rate of | 25 |
supplemented with fbs | 25 |
the result of | 25 |
reads mapping to | 25 |
of innate immune | 25 |
is important to | 25 |
of the m | 25 |
virus titers were | 25 |
compared to control | 25 |
in the control | 25 |
are able to | 25 |
together with the | 25 |
by western blotting | 25 |
s and l | 25 |
the sensitivity of | 25 |
difference in the | 25 |
the abundance of | 25 |
be able to | 25 |
the results of | 25 |
side of the | 25 |
and wt mice | 25 |
are consistent with | 25 |
to the plasma | 25 |
the respiratory tract | 24 |
suggested that the | 24 |
under the control | 24 |
was assessed by | 24 |
to play a | 24 |
is thought to | 24 |
its role in | 24 |
stored at uc | 24 |
length of the | 24 |
morbidity and mortality | 24 |
to wt mice | 24 |
innate and adaptive | 24 |
performed using the | 24 |
at the cell | 24 |
of ns and | 24 |
of two independent | 24 |
viral dna replication | 24 |
in mdck cells | 24 |
had no effect | 24 |
is an important | 24 |
to confirm that | 24 |
at hours post | 24 |
of a viral | 24 |
the ebola virus | 24 |
at the n | 24 |
the ends of | 24 |
cells per well | 24 |
emerging infectious diseases | 24 |
higher levels of | 24 |
the notion that | 24 |
use of the | 24 |
of the four | 24 |
h and h | 24 |
of di particles | 24 |
transfected with plasmids | 24 |
in text s | 24 |
i and iii | 24 |
of chikungunya virus | 24 |
close to the | 24 |
to the virus | 24 |
we compared the | 24 |
could be detected | 24 |
flock house virus | 24 |
correlated with the | 24 |
is necessary for | 24 |
which in turn | 24 |
d b gp | 24 |
were found in | 24 |
has been proposed | 24 |
as part of | 24 |
in a dose | 24 |
was observed for | 24 |
accordance with the | 24 |
the possibility of | 24 |
rna synthesis by | 24 |
was not affected | 24 |
structure of a | 24 |
with the indicated | 24 |
possible that the | 24 |
days post infection | 24 |
tumv intercellular movement | 24 |
of mhv spike | 24 |
did not show | 24 |
as indicated by | 23 |
we examined the | 23 |
previously shown to | 23 |
and inhibition of | 23 |
incubated with the | 23 |
and used to | 23 |
shown in the | 23 |
we tested whether | 23 |
for hours at | 23 |
in the regulation | 23 |
were shown to | 23 |
majority of the | 23 |
portion of the | 23 |
corresponds to the | 23 |
comparison of the | 23 |
the increase in | 23 |
be explained by | 23 |
consistent with this | 23 |
as a template | 23 |
of a new | 23 |
the association of | 23 |
the inhibitory effect | 23 |
the mean of | 23 |
h a replication | 23 |
followed by incubation | 23 |
and use committee | 23 |
with fetal bovine | 23 |
on the surface | 23 |
c bl mice | 23 |
indicated time points | 23 |
been demonstrated to | 23 |
sev cantell ld | 23 |
with the same | 23 |
in mice infected | 23 |
virus in the | 23 |
we were able | 23 |
it may be | 23 |
hepatitis virus strain | 23 |
critical role in | 23 |
of at least | 23 |
were cultured in | 23 |
of cells with | 23 |
we sought to | 23 |
of the reassortant | 23 |
were used in | 23 |
the capacity of | 23 |
we demonstrated that | 23 |
are shown as | 23 |
data are presented | 23 |
of the family | 23 |
the involvement of | 23 |
the in vivo | 23 |
the indicated time | 23 |
the viral life | 23 |
bound to the | 23 |
respiratory syndrome virus | 23 |
the kinetics of | 23 |
are thought to | 23 |
c virus rna | 23 |
leads to the | 23 |
for the presence | 23 |
the specificity of | 23 |
can also be | 23 |
incubation at uc | 23 |
previous studies have | 23 |
fmdv l pro | 23 |
essential for the | 23 |
are presented as | 23 |
in the supernatant | 23 |
viruses have been | 23 |
likely due to | 23 |
ebola virus glycoprotein | 23 |
resulted in the | 23 |
the viral capsid | 23 |
in the gut | 23 |
but not the | 23 |
a significant reduction | 23 |
in fig b | 23 |
the position of | 23 |
was generated by | 23 |
and s b | 23 |
these data demonstrate | 23 |
thermo fisher scientific | 23 |
or in the | 23 |
to the same | 23 |
was detected by | 23 |
were unable to | 23 |
the introduction of | 23 |
for the development | 23 |
recombinant ded p | 23 |
stat and grb | 23 |
mapped to the | 23 |
by the addition | 23 |
and use of | 23 |
is capable of | 23 |
were then washed | 23 |
protein in the | 23 |
a panel of | 23 |
of a virus | 23 |
by the viral | 23 |
added to each | 22 |
the cut site | 22 |
cells were co | 22 |
of the wt | 22 |
upstream of the | 22 |
using the same | 22 |
the indicated times | 22 |
to the n | 22 |
at and hpi | 22 |
that had been | 22 |
was required for | 22 |
inhibitory effect of | 22 |
the basis of | 22 |
site in the | 22 |
in s fig | 22 |
differences between the | 22 |
in figure s | 22 |
note that the | 22 |
cells were cultured | 22 |
for h before | 22 |
single amino acid | 22 |
in the n | 22 |
and function of | 22 |
the capacity to | 22 |
the sars coronavirus | 22 |
of the other | 22 |
s fig and | 22 |
tumor necrosis factor | 22 |
in utero zikv | 22 |
effect of the | 22 |
interactions between the | 22 |
of dengue virus | 22 |
those of the | 22 |
infection and the | 22 |
the united states | 22 |
in utero infection | 22 |
of ptx in | 22 |
to our knowledge | 22 |
e and f | 22 |
initial binding rate | 22 |
in the pre | 22 |
structural basis for | 22 |
in pbs containing | 22 |
resulting in the | 22 |
transfected with a | 22 |
in patients with | 22 |
of mice infected | 22 |
of the cellular | 22 |
has been previously | 22 |
were quantified by | 22 |
of the complex | 22 |
observed for the | 22 |
of human cytomegalovirus | 22 |
positive cells were | 22 |
and stained for | 22 |
leads to a | 22 |
dmem supplemented with | 22 |
cloned into the | 22 |
possibility that the | 22 |
are responsible for | 22 |
had fiber head | 22 |
antiviral activity of | 22 |
in the infected | 22 |
to a final | 22 |
the hepatitis c | 22 |
free virus particles | 22 |
structure and function | 22 |
p p modification | 22 |
of the first | 22 |
and the cells | 22 |
to confirm the | 22 |
rna synthesis in | 22 |
plaque assay on | 22 |
virus infection by | 22 |
at the university | 22 |
a cd t | 22 |
was kindly provided | 21 |
mouse model of | 21 |
because of the | 21 |
gut cd t | 21 |
formation of the | 21 |
control of the | 21 |
the side chain | 21 |
surface of the | 21 |
viral life cycle | 21 |
of viral dna | 21 |
is required to | 21 |
protein kinase c | 21 |
associated with a | 21 |
be noted that | 21 |
utero zikv infection | 21 |
hendra and nipah | 21 |
viral and cellular | 21 |
for min to | 21 |
did not significantly | 21 |
of rna synthesis | 21 |
cells and the | 21 |
no significant differences | 21 |
and the virus | 21 |
not appear to | 21 |
absence of the | 21 |
has been described | 21 |
was subjected to | 21 |
the sinv replicase | 21 |
carried out as | 21 |
virus nonstructural protein | 21 |
and subjected to | 21 |
results were obtained | 21 |
complex with the | 21 |
the degree of | 21 |
capsid protein and | 21 |
luciferase activity was | 21 |
not yet been | 21 |
wt d b | 21 |
hours post infection | 21 |
in this case | 21 |
be important for | 21 |
due to its | 21 |
and of the | 21 |
to test the | 21 |
that the majority | 21 |
of these proteins | 21 |
linked to the | 21 |
of cytokine signaling | 21 |
normalized to the | 21 |
amino acid residues | 21 |
the onset of | 21 |
not essential for | 21 |
may also be | 21 |
more than of | 21 |
presented as mean | 21 |
protease inhibitor cocktail | 21 |
is not clear | 21 |
human monoclonal antibody | 21 |
the wt and | 21 |
should be noted | 21 |
stably transduced with | 21 |
cells were collected | 21 |
then incubated with | 21 |
the sfv complex | 21 |
cleavage of the | 21 |
conformational changes in | 21 |
rna in the | 21 |
were lysed and | 21 |
adaptive immune response | 21 |
of infectious hcv | 21 |
the diversity of | 21 |
were infected at | 21 |
that it is | 21 |
a function of | 21 |
encoded by the | 21 |
more than one | 21 |
large number of | 21 |
at least one | 21 |
the virus in | 21 |
is similar to | 21 |
early and late | 21 |
were stimulated with | 21 |
belonging to the | 21 |
this is the | 21 |
p replication protein | 21 |
rna virus replication | 21 |
was extracted from | 21 |
a combination of | 21 |
induction of socs | 21 |
and atrh helicases | 21 |
of template rnas | 21 |
of viral particles | 21 |
of the capsid | 21 |
the crystal structures | 21 |
sox cut sites | 21 |
removal of the | 21 |
the capsid protein | 21 |
were obtained by | 21 |
away from the | 21 |
with the following | 21 |
affected by the | 21 |
for hr at | 21 |
the interactions between | 21 |
results in the | 21 |
transfected with the | 20 |
the genome of | 20 |
of infectious particles | 20 |
at a multiplicity | 20 |
and did not | 20 |
h ss n | 20 |
of viral infection | 20 |
which is a | 20 |
amav and tcrv | 20 |
were identified in | 20 |
fixed and stained | 20 |
an inhibitor of | 20 |
of t cells | 20 |
of a functional | 20 |
was obtained from | 20 |
of the ppxy | 20 |
the conformation of | 20 |
antibodies were used | 20 |
sev cantell hd | 20 |
fraction of the | 20 |
three times with | 20 |
from infected cells | 20 |
used as the | 20 |
ss n ps | 20 |
c rasm a | 20 |
compared to those | 20 |
t cell receptor | 20 |
twice with pbs | 20 |
clarified by centrifugation | 20 |
of the genomic | 20 |
virus infected cells | 20 |
was determined in | 20 |
is a major | 20 |
we would like | 20 |
i and mda | 20 |
reported to be | 20 |
in human and | 20 |
not affected by | 20 |
the host immune | 20 |
the interaction with | 20 |
important for the | 20 |
the significance of | 20 |
two of the | 20 |
the present study | 20 |
the ma virus | 20 |
to evaluate the | 20 |
activity in the | 20 |
is that the | 20 |
protein is a | 20 |
h after transfection | 20 |
rosavirus c rasm | 20 |
shown that the | 20 |
required for viral | 20 |
for virus replication | 20 |
of the immune | 20 |
of wt mice | 20 |
is supported by | 20 |
for analysis of | 20 |
viral rna in | 20 |
to cry b | 20 |
replication and transcription | 20 |
during the course | 20 |
in viral rna | 20 |
change in the | 20 |
fold dilutions of | 20 |
statistical analysis was | 20 |
institutional animal care | 20 |
the genomic rna | 20 |
representation of the | 20 |
and samd l | 20 |
the nucleus and | 20 |
with sev cantell | 20 |
of the infection | 20 |
the treatment of | 20 |
in control cells | 20 |
for min in | 20 |
based on these | 20 |
in cells expressing | 20 |
of the interaction | 20 |
in the formation | 20 |
the distal ileum | 20 |
fig e and | 20 |
response to the | 20 |
one of these | 20 |
n influenza a | 20 |
of the l | 20 |
in a mouse | 20 |
be detected in | 20 |
by day p | 20 |
as evidenced by | 20 |
of human immunodeficiency | 20 |
in viral load | 20 |
was detected using | 20 |
is the most | 19 |
suppressor of cytokine | 19 |
host response to | 19 |
mpv and mpv | 19 |
institutes of health | 19 |
the limit of | 19 |
of the type | 19 |
were fixed in | 19 |
for production of | 19 |
was not detected | 19 |
in the m | 19 |
of host cell | 19 |
pcr was performed | 19 |
kshv lytic replication | 19 |
effects of the | 19 |
of sendai virus | 19 |
rpm for min | 19 |
n influenza virus | 19 |
transfected cells were | 19 |
rabbit polyclonal anti | 19 |
during chronic hiv | 19 |
as a model | 19 |
ss h ps | 19 |
hcv rna replication | 19 |
to understand the | 19 |
of rl mice | 19 |
to form a | 19 |
c and s | 19 |
under these conditions | 19 |
development of a | 19 |
of the gp | 19 |
s b table | 19 |
wt and mutant | 19 |
a member of | 19 |
and evolution of | 19 |
supporting information s | 19 |
for the first | 19 |
performed in triplicate | 19 |
decrease in the | 19 |
the infectivity of | 19 |
amplification of the | 19 |
entry of iav | 19 |
replication in vitro | 19 |
rna replication in | 19 |
and h n | 19 |
er and golgi | 19 |
there is an | 19 |
the entry of | 19 |
the absence or | 19 |
to measure the | 19 |
in this region | 19 |
heat shock protein | 19 |
type and mutant | 19 |
to further investigate | 19 |
viruses such as | 19 |
mechanisms by which | 19 |
allowed us to | 19 |
bovine serum albumin | 19 |
the outcome of | 19 |
proteins in the | 19 |
template rnas by | 19 |
of which are | 19 |
the potential to | 19 |
control and lipin | 19 |
in the brains | 19 |
and expression of | 19 |
is known about | 19 |
confirmed that the | 19 |
reactivated for h | 19 |
in the mouse | 19 |
were detected by | 19 |
japanese encephalitis virus | 19 |
by the presence | 19 |
cell lines were | 19 |
levels of the | 19 |
plays an important | 19 |
to analyze the | 19 |
and adaptive immune | 19 |
studies have shown | 19 |
were washed three | 19 |
important to note | 19 |
of laboratory animals | 19 |
of the individual | 19 |
of the same | 19 |
of the coronavirus | 19 |
than of the | 19 |
in nonhuman primates | 19 |
of the fusion | 19 |
of the innate | 19 |
cells with a | 19 |
infected cells was | 19 |
in influenza a | 19 |
levels in the | 19 |
figure a and | 19 |
of the tombusvirus | 19 |
was cloned into | 19 |
immune responses to | 19 |
rna synthesis and | 19 |
we showed that | 19 |
essential role in | 19 |
with type i | 19 |
and ifit mice | 19 |
of total rna | 19 |
supported by the | 19 |
or presence of | 19 |
some of these | 19 |
feline infectious peritonitis | 19 |
the degradation of | 19 |
has previously been | 19 |
in the respiratory | 19 |
levels of ifn | 19 |
of the replicase | 19 |
were allowed to | 19 |
to better understand | 19 |
the samples were | 19 |
h at room | 19 |
of the core | 19 |
were washed and | 19 |
and loss of | 19 |
the standard deviation | 19 |
rosavirus b and | 19 |
there are no | 19 |
that expression of | 19 |
order to determine | 19 |
results indicated that | 19 |
national institutes of | 19 |
and the other | 19 |
has been observed | 19 |
fetal calf serum | 19 |
an a footprint | 19 |
wt and sting | 19 |
the sequence of | 19 |
n ss h | 19 |
in association with | 19 |
have also been | 19 |
mice were euthanized | 18 |
samples were then | 18 |
in the number | 18 |
absence of a | 18 |
in mice and | 18 |
of the lhr | 18 |
be responsible for | 18 |
in wild type | 18 |
early during infection | 18 |
and found that | 18 |
gp on the | 18 |
and respiratory syndrome | 18 |
similar to those | 18 |
uc in a | 18 |
viral load in | 18 |
activity of c | 18 |
many of these | 18 |
at day post | 18 |
utilisation of template | 18 |
gene expression by | 18 |
the cns of | 18 |
one or more | 18 |
for each of | 18 |
cells with the | 18 |
a set of | 18 |
did not observe | 18 |
infected with a | 18 |
of mhv h | 18 |
interactions with the | 18 |
the discovery of | 18 |
the ns protein | 18 |
during viral infection | 18 |
cytokines and chemokines | 18 |
to the cells | 18 |
in a manner | 18 |
host gene expression | 18 |
the growth of | 18 |
shows that the | 18 |
levels of isg | 18 |
were confirmed by | 18 |
of the manuscript | 18 |
porcine reproductive and | 18 |
binding to p | 18 |
on vero cells | 18 |
during the early | 18 |
cell leukemia virus | 18 |
and la ts | 18 |
the cleavage site | 18 |
ml of pbs | 18 |
which has been | 18 |
side chain of | 18 |
proteins involved in | 18 |
of wt and | 18 |
mice sacrificed on | 18 |
release of infectious | 18 |
but did not | 18 |
disease control and | 18 |
the golgi apparatus | 18 |
extent of fusion | 18 |
deisgylase dub activity | 18 |
is the only | 18 |
k and k | 18 |
variation in the | 18 |
of the er | 18 |
in humans and | 18 |
as compared with | 18 |
were generated using | 18 |
experiment was repeated | 18 |
no significant difference | 18 |
is an essential | 18 |
the viral membrane | 18 |
and can be | 18 |
critical for the | 18 |
was calculated as | 18 |
course of infection | 18 |
shown in s | 18 |
are expressed as | 18 |
to viral infection | 18 |
proteins were detected | 18 |
day post infection | 18 |
we find that | 18 |
we report that | 18 |
these results are | 18 |
control and prevention | 18 |
need to be | 18 |
hev and niv | 18 |
of the genus | 18 |
of viral mrna | 18 |
of semliki forest | 18 |
of listeria monocytogenes | 18 |
figure s c | 18 |
immune responses and | 18 |
s in text | 18 |
of ev c | 18 |
infection with the | 18 |
reproductive and respiratory | 18 |
were then incubated | 18 |
were performed with | 18 |
the size of | 18 |
sacrificed on day | 18 |
stages of infection | 18 |
and virus production | 18 |
by the virus | 18 |
of convalescent plasma | 18 |
for hour at | 18 |
the new world | 18 |
conformation of the | 18 |
roles in the | 18 |
mapping to the | 18 |
isolated from a | 18 |
produced in the | 18 |
the availability of | 18 |
is present in | 18 |
using flow cytometry | 18 |
lower respiratory tract | 18 |
based on a | 18 |
context of the | 18 |
are present in | 18 |
min at rt | 18 |
the f protein | 18 |
positive and negative | 18 |
of the major | 18 |
and normalized to | 18 |
of the gene | 18 |
as demonstrated by | 18 |
absence or presence | 18 |
at the level | 18 |
in a single | 18 |
the mechanism by | 18 |
not result in | 18 |
infection of the | 18 |
in the c | 18 |
loss of the | 18 |
by alphavirus replicases | 18 |
this study was | 18 |
ross river virus | 18 |
the efficacy of | 18 |
is sufficient to | 18 |
that the presence | 18 |
of the ha | 18 |
the same as | 18 |
early stages of | 18 |
we performed a | 18 |
we have identified | 18 |
infection in vitro | 17 |
the asymmetric unit | 17 |
severe and non | 17 |
green fluorescent protein | 17 |
the coding region | 17 |
a key role | 17 |
observed that the | 17 |
coding region of | 17 |
for the care | 17 |
lead to the | 17 |
of viral and | 17 |
that are not | 17 |
also observed in | 17 |
on the viral | 17 |
due to an | 17 |
translation of the | 17 |
may play a | 17 |
in hek t | 17 |
to be important | 17 |
and in vitro | 17 |
primary and secondary | 17 |
along with the | 17 |
of the blv | 17 |
the nature of | 17 |
been observed in | 17 |
in transfected cells | 17 |
and d b | 17 |
of the infected | 17 |
b and b | 17 |
the virus was | 17 |
data are shown | 17 |
relative to wt | 17 |
induced by the | 17 |
to define the | 17 |
with the wt | 17 |
not in the | 17 |
performed in the | 17 |
data were analyzed | 17 |
major histocompatibility complex | 17 |
in table s | 17 |
not sufficient to | 17 |
that l pro | 17 |
and for the | 17 |
determine if the | 17 |
to a lesser | 17 |
the tgev rbd | 17 |
to generate the | 17 |
likely that the | 17 |
of the coiled | 17 |
as assessed by | 17 |
with previous studies | 17 |
that the virus | 17 |
the viral protein | 17 |
of hsp isoforms | 17 |
the sialic acid | 17 |
the initiation of | 17 |
it is clear | 17 |
we measured the | 17 |
medium was replaced | 17 |
the cytoplasm of | 17 |
with that of | 17 |
the idea that | 17 |
terminus of the | 17 |
immune response in | 17 |
this is in | 17 |
by binding to | 17 |
influenza virus hemagglutinin | 17 |
activity of l | 17 |
on the virus | 17 |
the negative strand | 17 |
on day post | 17 |
the viral polymerase | 17 |
the removal of | 17 |
the average of | 17 |
fixed with paraformaldehyde | 17 |
were separated by | 17 |
serial dilutions of | 17 |
caused by the | 17 |
cells were reactivated | 17 |
exclude the possibility | 17 |
data showed that | 17 |
the veev genome | 17 |
amino acid sequences | 17 |
in this paper | 17 |
the design of | 17 |
of pfu cell | 17 |
ppxy late domain | 17 |
region in the | 17 |
cleavage site in | 17 |
the rest of | 17 |
k b s | 17 |
that they are | 17 |
and used for | 17 |
of sars coronavirus | 17 |
blot analysis of | 17 |
were tested for | 17 |
media was removed | 17 |
of the antiviral | 17 |
an rna virus | 17 |
this is a | 17 |
may be due | 17 |
rather than the | 17 |
as a reference | 17 |
l pro c | 17 |
served as a | 17 |
isolated from the | 17 |
distribution of the | 17 |
cells were stimulated | 17 |
s d fig | 17 |
of a host | 17 |
igm and igg | 17 |
in the early | 17 |
as a function | 17 |
we analyzed the | 17 |
are grateful to | 17 |
molecular basis of | 17 |
to be more | 17 |
infected mice were | 17 |
viruses and their | 17 |
line with the | 17 |
for disease control | 17 |
nsp and nsp | 17 |
performed using a | 17 |
a determinant of | 17 |
supernatants were harvested | 17 |
and has been | 17 |
is also a | 17 |
at a final | 17 |
synthesis by the | 17 |
evolution of the | 17 |
in absence of | 17 |
transiently transfected with | 17 |
the first time | 17 |
we assessed the | 17 |
analyzed the data | 17 |
used to detect | 17 |
the inoculum was | 17 |
c virus replication | 17 |
mouth disease virus | 17 |
predicted to be | 17 |
sendai virus c | 17 |
in the replication | 17 |
a mixture of | 17 |
was observed when | 17 |
oas rnase l | 17 |
to calculate the | 17 |
were lysed in | 17 |
mice compared to | 17 |
of s and | 17 |
by interacting with | 17 |
of core protein | 17 |
body weight loss | 17 |
the appearance of | 17 |
for sting in | 17 |
the genital mucosa | 17 |
a solution of | 17 |
cell extracts were | 17 |
secondary antibodies were | 17 |
altered peptide ligand | 17 |
been linked to | 17 |
a significant decrease | 17 |
virus ns protein | 17 |
as described for | 17 |
in the second | 17 |
at the non | 17 |
but does not | 17 |
for viral rna | 17 |
domains of the | 17 |
and pathogenesis of | 16 |
a group of | 16 |
in the genome | 16 |
of mg ml | 16 |
as in the | 16 |
of lymphocytic choriomeningitis | 16 |
rna helicase and | 16 |
collected from the | 16 |
cells compared to | 16 |
that the observed | 16 |
of the template | 16 |
conjugated secondary antibodies | 16 |
extracted from the | 16 |
of host factors | 16 |
contributed to the | 16 |
dna sensing by | 16 |
at the highest | 16 |
identified as a | 16 |
in vitro transcription | 16 |
a concentration of | 16 |
cd ko cells | 16 |
essential for viral | 16 |
the spike protein | 16 |
defective interfering particles | 16 |
of the mean | 16 |
in control and | 16 |
collected at the | 16 |
limit of detection | 16 |
ability to cleave | 16 |
infected wild type | 16 |
ha na balance | 16 |
strand rna virus | 16 |
is one of | 16 |
fold change in | 16 |
from the cytoplasm | 16 |
were washed in | 16 |
is sensitive to | 16 |
was not observed | 16 |
infection in a | 16 |
not observed in | 16 |
elevated levels of | 16 |
the e g | 16 |
samples were collected | 16 |
we were unable | 16 |
the likelihood of | 16 |
out as described | 16 |
thought to be | 16 |
in the sbs | 16 |
functional analysis of | 16 |
are the most | 16 |
was generated from | 16 |
ded p and | 16 |
low level of | 16 |
proteins have been | 16 |
top of the | 16 |
host immune response | 16 |
s a and | 16 |
of the sinv | 16 |
c and tnf | 16 |
test this hypothesis | 16 |
to characterize the | 16 |
humoral responses in | 16 |
aspects of the | 16 |
infection in vivo | 16 |
the golgi complex | 16 |
in all cases | 16 |
antibodies specific for | 16 |
the potential of | 16 |
a functional receptor | 16 |
although it is | 16 |
are needed to | 16 |
was performed at | 16 |
h n and | 16 |
were transiently transfected | 16 |
is crucial for | 16 |
on the basis | 16 |
dn vps b | 16 |
the plates were | 16 |
we are grateful | 16 |
response to infection | 16 |
supplemented with fcs | 16 |
of the mouse | 16 |
did not have | 16 |
viral load and | 16 |
account for the | 16 |
during hcmv infection | 16 |
the case for | 16 |
in vivo and | 16 |
rnas by alphavirus | 16 |
c atpase is | 16 |
the form of | 16 |
have been implicated | 16 |
of the mhv | 16 |
the amino acid | 16 |
due to their | 16 |
our results show | 16 |
no evidence for | 16 |
and it is | 16 |
the secretion of | 16 |
propose that the | 16 |
in the er | 16 |
to of the | 16 |
by degrading cgas | 16 |
the care and | 16 |
times post infection | 16 |
and rnase l | 16 |
is based on | 16 |
resuspended in ml | 16 |
functional receptor for | 16 |
was replaced by | 16 |
for h in | 16 |
receptor binding and | 16 |
in support of | 16 |
respiratory tract infections | 16 |
has been suggested | 16 |
t cell activation | 16 |
in all three | 16 |
to have a | 16 |
increasing amounts of | 16 |
the viral replicase | 16 |
medium supplemented with | 16 |
inab and ifuse | 16 |
viral capsid protein | 16 |
was isolated using | 16 |
a humidified incubator | 16 |
simian immunodeficiency virus | 16 |
hours after infection | 16 |
cleavage of rlr | 16 |
infected with wild | 16 |
result in the | 16 |
of eif e | 16 |
and analysis of | 16 |
human and animal | 16 |
in the culture | 16 |
type and bid | 16 |
to induce the | 16 |
a b signaling | 16 |
seems to be | 16 |
of the t | 16 |
confirm that the | 16 |
of the murine | 16 |
significant differences in | 16 |
we investigated the | 16 |
that did not | 16 |
african green monkey | 16 |
previously shown that | 16 |
and s a | 16 |
sd of three | 16 |
er stress response | 16 |
is the major | 16 |
wt mice at | 16 |
effects on the | 16 |
is independent of | 16 |
each time point | 16 |
the p gene | 16 |
host and viral | 16 |
from different genera | 16 |
fusion hmpv f | 16 |
of defective interfering | 16 |
cellular response to | 16 |
were detected using | 16 |
rift valley fever | 16 |
resulted in an | 16 |
were determined using | 16 |
is not required | 16 |
t cell recognition | 16 |
the sox cut | 16 |
times with pbs | 16 |
s c table | 16 |
cells were transiently | 16 |
statistical significance was | 16 |
provided by the | 16 |
by incubation with | 16 |
the roles of | 16 |
that could be | 15 |
of the second | 15 |
of the negative | 15 |
in situ hybridization | 15 |
dbp p and | 15 |
interacting with the | 15 |
in dmem supplemented | 15 |
for in vitro | 15 |
before and after | 15 |
in the p | 15 |
moi of pfu | 15 |
hours post transfection | 15 |
the catalytic site | 15 |
using graphpad prism | 15 |
late time points | 15 |
avian influenza a | 15 |
were mixed with | 15 |
and added to | 15 |
it appears that | 15 |
the viral genomic | 15 |
been identified in | 15 |
is determined by | 15 |
the antiviral activity | 15 |
stained with anti | 15 |
been reported in | 15 |
replication and pathogenesis | 15 |
whole cell lysates | 15 |
at this time | 15 |
was due to | 15 |
different time points | 15 |
correlation between the | 15 |
adaptive immune responses | 15 |
c for min | 15 |
have been observed | 15 |
mice were inoculated | 15 |
presence of fcs | 15 |
in pbs for | 15 |
role for sting | 15 |
of the productive | 15 |
evolutionary history of | 15 |
depend on the | 15 |
wrote the paper | 15 |
in protein vi | 15 |
in some cases | 15 |
the cells with | 15 |
evidence for a | 15 |
in the current | 15 |
dengue virus infection | 15 |
mediated activation of | 15 |
ns and or | 15 |
location of the | 15 |
activation of nf | 15 |
the process of | 15 |
t cells are | 15 |
was allowed to | 15 |
the sequences of | 15 |
conceived and designed | 15 |
of the nsp | 15 |
centers for disease | 15 |
evp and mvp | 15 |
the adaptive immune | 15 |
have demonstrated that | 15 |
hematoxylin and eosin | 15 |
representative of two | 15 |
particles in the | 15 |
infected with either | 15 |
for the indicated | 15 |
of the central | 15 |
the location of | 15 |
reduction in viral | 15 |
set out to | 15 |
of the chikv | 15 |
to wnv infection | 15 |
sensing by degrading | 15 |
the cleavage of | 15 |
significant differences between | 15 |
the time course | 15 |
by comparing the | 15 |
temperature for h | 15 |
the tip of | 15 |
the most important | 15 |
in this work | 15 |
is in agreement | 15 |
of the corresponding | 15 |
and designed the | 15 |
to each well | 15 |
designed the experiments | 15 |
of all the | 15 |
conjugated goat anti | 15 |
the s and | 15 |
the suppression of | 15 |
virulence gene expression | 15 |
capsid protein vp | 15 |
has been associated | 15 |
of the ebola | 15 |
the selection of | 15 |
in innate immune | 15 |
in samd l | 15 |
are colored in | 15 |
it is unclear | 15 |
of neutralizing antibodies | 15 |
viral entry and | 15 |
the following day | 15 |
part of a | 15 |
and s c | 15 |
half of the | 15 |
virus fusion protein | 15 |
as opposed to | 15 |
levels of virus | 15 |
a period of | 15 |
transferred to a | 15 |
genes involved in | 15 |
difference between the | 15 |
mode of action | 15 |
antiviral cd t | 15 |
a sucrose cushion | 15 |
later time points | 15 |
which is the | 15 |
the influence of | 15 |
to bind to | 15 |
depends on the | 15 |
was measured using | 15 |
mouse samd l | 15 |
buffer containing mm | 15 |
the severity of | 15 |
mh mn ss | 15 |
not alter the | 15 |
y f and | 15 |
little is known | 15 |
subjected to western | 15 |
presence of ver | 15 |
hsc and ihsp | 15 |
correlate with the | 15 |
and treated with | 15 |
to replicate in | 15 |
implicated in the | 15 |
the active site | 15 |
in any of | 15 |
a single amino | 15 |
a previous study | 15 |
chikungunya virus inhibits | 15 |
for helpful discussions | 15 |
of the brain | 15 |
capacity of the | 15 |
formation of a | 15 |
of the d | 15 |
of virus infection | 15 |
influenza virus replication | 15 |
was added and | 15 |
of the rbd | 15 |
of the full | 15 |
of the wild | 15 |
between the ifn | 15 |
is located in | 15 |
to test whether | 15 |
in the induction | 15 |
to the presence | 15 |
the inflammatory response | 15 |
infected with pfu | 15 |
infection with a | 15 |
a comparison of | 15 |
to the wt | 15 |
overnight at uc | 15 |
evidence for the | 15 |
at uc with | 15 |
leukemia virus type | 15 |
is dispensable for | 15 |
increase in viral | 15 |
production of the | 15 |
viral titers were | 15 |
was not due | 15 |
inhibits dna sensing | 15 |
of progeny virions | 15 |
flow cytometry analysis | 15 |
the a footprint | 15 |
least in part | 15 |
the next day | 15 |
acts as a | 15 |
indicates that the | 15 |
number of reads | 15 |
in this context | 15 |
our results indicate | 15 |
as early as | 15 |
cell monolayers were | 15 |
in brains of | 15 |
human respiratory syncytial | 15 |
of the ns | 15 |
was analyzed using | 15 |
npn a peptide | 15 |
a lesser extent | 15 |
its interaction with | 15 |
and or ns | 15 |
were calculated using | 15 |
to the development | 15 |
is indicated by | 15 |
in the rd | 15 |
the concentration of | 15 |
at a concentration | 15 |
the early secretory | 15 |
new england biolabs | 15 |
viral protein synthesis | 15 |
em structure of | 15 |
the results showed | 15 |
virus inhibits dna | 15 |
mhc class ii | 15 |
on ice for | 15 |
intensity of the | 15 |
sought to determine | 15 |
for each virus | 15 |
cells in a | 15 |
plays a critical | 15 |
then added to | 15 |
in conjunction with | 15 |
in fig c | 15 |
is regulated by | 15 |
were cloned into | 15 |
in vero cells | 15 |
of the hmpv | 15 |
the difference in | 15 |
in the different | 15 |
was digested with | 15 |
and s table | 15 |
to inhibit the | 15 |
of the mrna | 15 |
representative of three | 15 |
the receptor binding | 15 |
of the catalytic | 15 |
size of the | 15 |
a density of | 15 |
regions in the | 15 |
this was not | 15 |
we have shown | 15 |
the phosphorylation of | 15 |
rna polymerase ii | 15 |
no difference in | 15 |
we do not | 14 |
t rna polymerase | 14 |
this study we | 14 |
of the cytoplasmic | 14 |
in the cytosol | 14 |
of herpes simplex | 14 |
at a density | 14 |
weight loss and | 14 |
in pro cells | 14 |
of infection in | 14 |
the s segment | 14 |
protein that is | 14 |
the fusion protein | 14 |
santa cruz biotechnology | 14 |
other cell types | 14 |
we tested the | 14 |
and h post | 14 |
structural analysis of | 14 |
presence of an | 14 |
of the mie | 14 |
at the site | 14 |
of the e | 14 |
significant difference in | 14 |
early stage of | 14 |
to ensure that | 14 |
gene expression was | 14 |
in each of | 14 |
of the different | 14 |
that map to | 14 |
findings suggest that | 14 |
in vitro studies | 14 |
was analyzed by | 14 |
was present in | 14 |
in influenza virus | 14 |
density in the | 14 |
be affected by | 14 |
located at the | 14 |
listed in s | 14 |
of the structural | 14 |
amplified by pcr | 14 |
through er and | 14 |
s e fig | 14 |
upon infection with | 14 |
did not result | 14 |
to the right | 14 |
a k a | 14 |
they do not | 14 |
the er stress | 14 |
h of infection | 14 |
i ifn receptor | 14 |
activity towards k | 14 |
a lack of | 14 |
that interact with | 14 |
b y f | 14 |
correspond to the | 14 |
lower than that | 14 |
to investigate whether | 14 |
number of viruses | 14 |
of an a | 14 |
for efficient replication | 14 |
virus infection is | 14 |
a large number | 14 |
more likely to | 14 |
the full length | 14 |
side chains of | 14 |
growth factor receptor | 14 |
use of laboratory | 14 |
the action of | 14 |
the supernatant of | 14 |
and standard deviation | 14 |
ml of the | 14 |
association of the | 14 |
of a human | 14 |
proteins that are | 14 |
to be an | 14 |
with severe acute | 14 |
and hours post | 14 |
impact on the | 14 |
phase of the | 14 |
during virus infection | 14 |
residue in the | 14 |
table s in | 14 |
in trex bcbl | 14 |
the mixing test | 14 |
the env tmd | 14 |
yet to be | 14 |
of a cells | 14 |
to type i | 14 |
extents of fusion | 14 |
comparative analysis of | 14 |
as rdrp initiation | 14 |
in the genital | 14 |
bind to a | 14 |
cell response via | 14 |
combined with the | 14 |
the human cytomegalovirus | 14 |
were associated with | 14 |
serological assays for | 14 |
cellular and viral | 14 |
with a single | 14 |
new world bat | 14 |
have been previously | 14 |
are presented in | 14 |
peptide ligand vaccination | 14 |
the initial binding | 14 |
valley fever virus | 14 |
is clear that | 14 |
t cells with | 14 |
host factors in | 14 |
we next determined | 14 |
induction of apoptosis | 14 |
btv ns m | 14 |
into host cells | 14 |
and the supernatant | 14 |
in liquid nitrogen | 14 |
that has been | 14 |
fact that the | 14 |
calculated using the | 14 |
both in vitro | 14 |
in tissue culture | 14 |
human coronavirus e | 14 |
were isolated from | 14 |
replication in cell | 14 |
in our study | 14 |
ratio of the | 14 |
quantification of the | 14 |
n and n | 14 |
cells were plated | 14 |
in severe and | 14 |
for expression of | 14 |
infected with veev | 14 |
of mapk erk | 14 |
of the hsp | 14 |
initiation factor in | 14 |
efficiency of the | 14 |
early secretory pathway | 14 |
day after infection | 14 |
virus infection of | 14 |
incubated overnight at | 14 |
would be expected | 14 |
of the inhibitor | 14 |
is not essential | 14 |
mtase as rdrp | 14 |
in the binding | 14 |
infected at an | 14 |
type and ips | 14 |
d b y | 14 |
recombinant mhv s | 14 |
expression levels were | 14 |
the antiviral response | 14 |
e and e | 14 |
in presence of | 14 |
by the tombusvirus | 14 |
all of which | 14 |
a ratio of | 14 |
standard deviation of | 14 |
sites in the | 14 |
added to a | 14 |
calculated as the | 14 |
the cell membrane | 14 |
cells at uc | 14 |
and mhv h | 14 |
mediated restriction of | 14 |
the mixture was | 14 |
and infected with | 14 |
luciferase activity in | 14 |
this may be | 14 |
of this study | 14 |
expression of ifn | 14 |
yeast dbp p | 14 |
no evidence of | 14 |
for binding to | 14 |
of the tgev | 14 |
of the trimer | 14 |
of serological assays | 14 |
amino acid substitution | 14 |
compared to mock | 14 |
mice immunized with | 14 |
the origin of | 14 |
higher level of | 14 |
a dilution of | 14 |
essential amino acids | 14 |
play an important | 14 |
been reported for | 14 |
of samd l | 14 |
factor in ns | 14 |
footprint on the | 14 |
the matrix protein | 14 |
genomic rna and | 14 |
by a single | 14 |
by measuring the | 14 |
all samples were | 14 |
the wt virus | 14 |
significant decrease in | 14 |
to compare the | 14 |
which is consistent | 14 |
of the sox | 14 |
our data suggest | 14 |
result of the | 14 |
performed the experiments | 14 |
can interact with | 14 |
of the peptide | 14 |
means sd of | 14 |
in spite of | 14 |
after which the | 14 |
our finding that | 14 |
new insights into | 14 |
could be a | 14 |
level in the | 14 |
detection of sars | 14 |
tgev and prcv | 14 |
in this report | 14 |
small molecule inhibitors | 14 |
or infected with | 14 |
and incubated in | 14 |
g and g | 14 |
it would be | 14 |
of the hemagglutinin | 14 |
in at least | 14 |
was amplified by | 14 |
helicase activity of | 14 |
assigned to the | 14 |
viral rna and | 14 |
in the present | 14 |
back to the | 14 |
responses in severe | 14 |
the risk of | 14 |
ends of the | 14 |
t cells that | 14 |
sodium dodecyl sulfate | 14 |
proteins of the | 14 |
infected with sev | 14 |
were analyzed for | 14 |
key role in | 14 |
was not significantly | 14 |