This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-000933-nn9gj0z1 | Dual wavelength imaging allows analysis of membrane fusion of influenza virus inside cells Pharmacological inhibition of endocytic pathways: is it specific enough to be useful? |
| cord-266078-h53zpjab | The more the merrier? |
| cord-262248-q5eijunp | Return to the past: the case for antibody- based therapies in infectious diseases Update: Ebola Virus Disease Epidemic- West Africa Plant- based vaccines against viruses Hyperimmune serum from healthy vaccinated individuals for Ebola virus disease? |
| cord-001859-d62iuk72 | The second potentially druggable heat shock protein and molecular chaperone? |
| cord-312743-9e4yufo5 | Evolution of carbohydrate antigens- microbial forces shaping host glycomes? |
| cord-001700-c6elsnag | Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations Phylogenetic assessment of filoviruses: how many lineages of Marburg virus? |
| cord-001992-m4k20i7g | How does the PPXY late domain of LCMV promote the release of DI particles? |
| cord-000127-tkxpjlyn | Is there evidence that favors either of these potential evolutionary mechanisms? |
| cord-262753-jld1ygxt | -is there a P function in vesicular stomatitis virus? |
| cord-001541-5d64esp4 | The transcription complex of vesicular stomatitis virus Transcription and replication of nonsegmented negative- strand RNA viruses Origins of genes:"big bang"or continuous creation? |
| cord-304815-3datxv8j | Who controls the samples? |
| cord-001769-2sdg5ll7 | The convergence of multiple signalling pathways on ROS production? |
| cord-275307-d7htyfcl | Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells Global or local? |
| cord-001385-rb5vwolt | Specific inhibition of a pathogenic receptor tyrosine kinase by its transmembrane domain Computational design of peptides that target transmembrane helices Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling Location, location, location: is membrane partitioning everything when it comes to innate immune activation? |
| cord-278511-je1509ar | How can this be addressed? |
| cord-269466-9hnal9ad | How do Plant Viruses Utilize the Host Secretory Pathway for Efficient Viral Replication and Spread? |
| cord-269466-9hnal9ad | Tomato bushy stunt virus Ubiquitination of tombusvirus p33 replication protein plays a role in virus replication and binding to the host Vps23p ESCRT protein Arabidopsis myosin XI- K localizes to the motile endomembrane vesicles associated with F- actin The cell biology of Tobacco mosaic virus replication and movement Myosindependent endoplasmic reticulum motility and F- actin organization in plant cells Integrity of the early secretory pathway promotes, but is not required for, severe acute respiratory syndrome coronavirus RNA synthesis and virus- induced remodeling of endoplasmic reticulum membranes Missing links? |
| cord-003169-bdw5ke4i | Neuraminidase receptor binding variants of human influenza A(H3N2) viruses resulting from substitution of aspartic acid 151 in the catalytic site: a role in virus attachment? |
| cord-002893-d7hetoq0 | Mice described in Fig 2A were Emerging viral diseases: confronting threats with new technologies Cross- species virus transmission and the emergence of new epidemic diseases Poxvirus cell entry: how many proteins does it take? |
| cord-002893-d7hetoq0 | So why are both SAMD9 and SAMD9L kept in humans and many other mammals? |
| cord-289879-fh7ic0kp | The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host Characterization of the Influenza a Virus Gene Pool in Avian Species in Southern China: Was H6N1 a Derivative or a Precursor of H5N1? |
| cord-000025-6zrv687k | : Has something changed? |
| cord-000025-6zrv687k | This differential requirement for components of the immune response in different organs raises an important question about norovirus pathogenesis and lymphoid infection: are the cells infected in intestine and MLN the same? |
| cord-013526-6fip93l2 | Extracellular Vesicles Mediate Receptor- Independent Transmission of Novel Tick- Borne Bunyavirus Extracellular vesicles: a new communication paradigm? |
| cord-002142-tdgu9sr9 | Nitric Oxide Increases Susceptibility of Toll- like Receptor- Activated Macrophages to Spreading Listeria monocytogenes Bacterial adaptation to oxidative stress: implications for pathogenesis and interaction with phagocytic cells Life of Listeria monocytogenes in the host cells'cytosol Bacterial production of methylglyoxal: a survival strategy or death by misadventure? |
| cord-290617-45be6gxe | G cytidine deaminase association with coronavirus nucleocapsid protein Evidence for host- dependent RNA editing in the transcriptome of SARS- CoV-2 Human coronaviruses: what do they cause? |
| cord-290617-45be6gxe | Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses? |
| cord-264579-csro48ks | Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine- based activation motif Binding of intrinsically disordered proteins is not necessarily accompanied by a structural transition to a folded form Multichain immune recognition receptor signaling: different players, same game? |
| cord-314451-mqnqjn0c | Summary of a technical meeting 25- 26 Is there an ideal animal model for SARS? |
| cord-001257-t21l6i3f | Distinct DDX DEAD- box RNA helicases cooperate to modulate the HIV-1 Rev function From promoting to inhibiting: diverse roles of helicases in HIV-1 Replication Viruses and the human DEAD- box helicase DDX3: inhibition or exploitation? |
| cord-001257-t21l6i3f | REN stimulatory for replication? |
| cord-003441-810r5q03 | The papain- like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain- like protease? |
| cord-003441-810r5q03 | a report of a laboratory infection and serological survey of human sera from three different states of India Outbreak of arbovirus infection in the Tadzhik SSR due to the Issyk- Kul virus Laboratory infections with Ganjam virus Thunderclap headache caused by Erve virus? |
| cord-278569-yr06jwm1 | Do men have a higher case fatality rate of severe acute respiratory syndrome than women do? |
| cord-287219-qxkwjkif | Did Merck's failed HIV vaccine cause harm? |
| cord-287219-qxkwjkif | The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development? |
| cord-325624-6anybxnk | When can axonal injury be beneficial? |
| cord-286137-4cbh3u3z | Could nutrition also actively shape how viruses evolve? |
| cord-286137-4cbh3u3z | So, do viruses harboring higher genetic diversity initially fare better in establishing an infection and displaying virulent phenotypes? |
| cord-002125-anp238gu | Do lipid rafts mediate virus assembly and pseudotyping? |
| cord-311383-1aqt65cc | Molecular dynamics simulations and multiple X- ray structure analyses Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain- like protease? |
| cord-311383-1aqt65cc | What are the functions of these modules? |
| cord-253783-3a1qde41 | Gastric acidity protects mice against prion infection? |
| cord-253783-3a1qde41 | Trapped conformation of full- length ovine prion protein induced by adsorption on clays Glutamic acid deamination in the presence of montmorillonite Synthesis of long prebiotic oligomers on mineral surfaces Interactions between prion protein isoforms: The kiss of death? |
| cord-332747-u46xryoo | Case Closed? |
| cord-001655-uqw74ra0 | Presence of neutralizing antibodies against Junin virus( Argentine hemorrhagic fever) in guinea pigs infected with Tacaribe virus Cross- protection in nonhuman primates against Argentine hemorrhagic fever Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest A revision of the system of nomenclature for influenza viruses: a WHO Memorandum The Modern U.S. Reptile Industry Wet markets- a continuing source of severe acute respiratory syndrome and influenza? |
| cord-268388-kkhuzf3p | Epidemic potential or a storm in a teacup? |
| cord-268388-kkhuzf3p | What are our pharmacotherapeutic options for MERS- CoV? |
| cord-267149-5twx9y5c | This correlation suggests that TfR1 use is a key determinant in the virulence of clade B viruses, which raises an important question: how easily might clade B viruses circulating in animals gain the ability to use human TfR1? |
| cord-002542-f7l4ty2j | A Potential New Human Antiviral Immunostimulatory Defective Viral Genomes from Respiratory Syncytial Virus Promote a Strong Innate Antiviral Response during Infection in Mice and Humans Effects of defective interfering viruses on virus replication and pathogenesis in vitro and in vivo Defective viral genomes arising in vivo provide critical danger signals for the triggering of lung antiviral immunity Engineering of homologous recombination hotspots with AU- rich sequences in brome mosaic virus Identification and manipulation of the molecular determinants influencing poliovirus recombination Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad- spectrum antivirals? |
| cord-002542-f7l4ty2j | An inevitable consequence of an error- prone polymerase? |
| cord-002542-f7l4ty2j | Why do RNA viruses recombine? |
| cord-011380-kfkp1zpn | So how does it possibly work at the molecular level? |
| cord-294342-7ycgd0h7 | Does low pH directly cause conformational changes in EBOV GP to induce fusion, or does it work via increasing the activity of cathepsins, or both[ 7, 20]? |
| cord-294342-7ycgd0h7 | The question now becomes: how readily does a fusion pore enlarge when connecting an EBOV envelope with an endosomal membrane? |
| cord-280221-s6oxq772 | Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding The SARS, MERS and novel coronavirus( COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? |
| cord-280221-s6oxq772 | I. Infection enhancement by non- neutralizing antibody Convalescent plasma: new evidence for an old therapeutic tool? |
| cord-280221-s6oxq772 | Is COVID-19 receiving ADE from other coronaviruses? |
| cord-356115-vblgotjn | Does the analysis of MHV- A59 ts mutants help us to understand these complex processes? |
| cord-353703-u86ggw11 | How does the stressed out ER find relief during virus infection? |
| cord-000578-jhetyd9t | Thus, can tombusviruses and other small RNA viruses replicate without the use of a helicase or they subvert a cellular helicase(s) to assist their replication? |
| cord-000578-jhetyd9t | Why would TBSV utilize both an RNA chaperone and an RNA helicase? |
| cord-342291-imn7g084 | What is the biological role of the bat IAV surface glycoproteins? |
| cord-351548-jvl63652 | An alternative view on an outdated hypothesis Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer? |
| cord-264225-vzcfeh7t | Chiang Mai HEPS Working Group New insights into HIV-1 specific cytotoxic T- lymphocyte responses in exposed, persistently seronegative Kenyan sex workers Cervical HIV- specific IgA in a population of commercial sex workers correlates with repeated exposure but not resistance to HIV HIV vaccine development in the aftermath of the STEP study: re- focus on occult HIV infection? |
| cord-264225-vzcfeh7t | The Clustering of Infected SIV Cells in Lymphatic Tissue Glycerol monolaurate prevents mucosal SIV transmission Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection Heterogeneity and plasticity of T helper cells Cellular heterogeneity: do differences make a difference? |
| cord-341034-2oigu75k | AMPKmediated inhibition of mTOR kinase is circumvented during immediate- early times of human cytomegalovirus infection Treatment of insulin resistance with metformin in naive genotype 1 chronic hepatitis C patients receiving peginterferon alfa-2a plus ribavirin Pioglitazone as adjuvant therapy in chronic hepatitis C: sequential rather than concomitant administration with pegylated interferon and ribavirin? |
| cord-341034-2oigu75k | Semliki Forest virus RNA requires continuous lipid synthesis Role of Cellular Lipids in Positive- Sense RNA Virus Replication Complex Assembly and Function Molecular biology of rift valley Fever virus Intracellular distribution of rubella virus nonstructural protein P150 Characterization of rubella virus replication complexes using antibodies to double- stranded RNA Ultrastructure of Kunjin virus- infected cells: colocalization of NS1 and NS3 with double- stranded RNA, and of NS2B with NS3, in virus- induced membrane structures Replication and gene function in Kunjin virus Kunjin RNA replication and applications of Kunjin replicons Molecular and ultrastructural analysis of heavy membrane fractions associated with the replication of Kunjin virus RNA Wrapping things up about virus RNA replication Kunjin virus: an Australian variant of West Nile? |
| cord-000246-mlhd9zbs | + CD8+ T cell response a consequence of diminished naïve CTL[ 33]? |
| cord-000246-mlhd9zbs | Can the smaller response to D b NPN3A be correlated with structural constraints or any decrease in stability for the pMHC- I complex? |
| cord-000246-mlhd9zbs | What would be the case for TCR responses elicited by influenza A viruses expressing the mutant NPN3A peptide in the native viral protein? |
| cord-265947-7j9qqi8w | Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases Structure of influenza virus N7: the last piece of the neuraminidase"jigsaw"puzzle A secondary sialic acid binding site on influenza virus neuraminidase: fact or fiction? |
| cord-265947-7j9qqi8w | Virus Receptor Binding Neuraminidase receptor binding variants of human influenza A(H3N2) viruses resulting from substitution of aspartic acid 151 in the catalytic site: a role in virus attachment? |
| cord-265947-7j9qqi8w | What adaptive changes in hemagglutinin and neuraminidase are necessary for emergence of pandemic influenza virus from its avian precursor? |
| cord-324928-cpryxa6p | A neglected public health concern? |
| cord-324928-cpryxa6p | This raises an intriguing question: did a SINV- like ancestor lose its ability to replicate in vertebrates or did an EILV- like ancestor acquire the ability to replicate in a vertebrate host? |
| cord-286072-kgpvdb42 | : What Do They All Do? |
| cord-286072-kgpvdb42 | How the SARS coronavirus causes disease: host or organism? |
| cord-013481-3zwq67do | Could IFNβ have distinct biological effects that are likely not due to other IFN- Is? |
| cord-013481-3zwq67do | Which ISGs are responsible for the discordant effects of IFN- Is at distinct phases of infection with persistent viruses? |
| cord-013481-3zwq67do | e.g., IFNα2 for HIV-1 infection) achieve the same in vivo effect as that of more potent IFN- Is( e.g., IFNα14)? |
| cord-316999-712rit8h | A neglected concept in invasion ecology? |
| cord-316999-712rit8h | Parasites lost- do invaders miss the boat or drown on arrival? |
| cord-316999-712rit8h | The importance of disease- mediated invasions Is invasion success explained by the enemy release hypothesis? |
| cord-076082-4kpkhz0o | Can cats spread avian flu? |
| cord-076082-4kpkhz0o | Could cats, or other non- avian species, have played a role in spreading the reassortant viruses in Java? |
| cord-076082-4kpkhz0o | Similarly, could cats act as amplifying hosts facilitating viral expansion and cross- species transmission, as civets did in the SARS outbreaks[ 52]? |
| cord-076082-4kpkhz0o | What factors have contributed to the apparent difference in the growth of genetic diversity? |
| cord-302340-pw2xqhwa | Is there a common characteristic shared by IFITM3-susceptible viruses? |
| cord-302340-pw2xqhwa | These studies also raise new questions including i) how do IFN and IFITM3 prevent viral fusion? |
| cord-302340-pw2xqhwa | and iii) is the latter action required for viral restriction, or alternatively does it arise as an outcome of IFITM3's potential cellular role? |
| cord-302340-pw2xqhwa | how do IFN and IFITM3 alter the endosomal and autolysosomal compartments? |
| cord-316584-b1aa1lri | A New Respiratory Threat? |
| cord-316584-b1aa1lri | Does CAR expression on erythrocytes lead to an advantage for host or virus? |
| cord-316584-b1aa1lri | Has CAR expression on erythrocytes put a selective pressure on Ads( and coxsackie B viruses that also bind CAR) to avoid an erythrocyte virus trap[ 28]? |
| cord-316584-b1aa1lri | Or has CAR expression by erythrocytes allowed HAds to thrive because it has allowed open access to so many more tissues and cell types? |
| cord-316584-b1aa1lri | binding, adhesion strengthening, and changes in viral structure CAR chasing: canine adenovirus vectors- all bite and no bark? |
| cord-304747-ojyxs3cp | At what age does infection typically occur? |
| cord-304747-ojyxs3cp | If so, what kind of disease does it cause? |
| cord-304747-ojyxs3cp | SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen Creation of human tumour cells with defined genetic elements Is there a role for SV40 in human cancer? |
| cord-304747-ojyxs3cp | This discovery raises many questions for further investigation, such as, Is WU virus a human pathogen? |
| cord-304747-ojyxs3cp | Where in the body does WU virus reside? |
| cord-290253-hxxizipk | Across 95 Drosophila Species Upper thermal limits of Drosophila are linked to species distributions and strongly constrained phylogenetically Upper thermal limits in terrestrial ectotherms: how constrained are they? |
| cord-290253-hxxizipk | Are extreme temperatures a stress? |
| cord-290253-hxxizipk | How will global climate change affect parasite- host assemblages? |
| cord-290253-hxxizipk | The role of genotype- by- environment interactions in sexual selection How will global climate change affect parasite- host assemblages? |
| cord-290253-hxxizipk | The thermal mismatch hypothesis explains host susceptibility to an emerging infectious disease Genotype- environment interaction and the evolution of phenotypic plasticity Quantitative Genetics and the Evolution of Reaction Norms Genotype- by- environment interactions and adaptation to local temperature affect immunity and fecundity in Drosophila melanogaster Coexistence of Similar Genotypes of Daphnia magna in Intermittent Populations: Response to Thermal Stress Temperature checks the Red Queen? |
| cord-290253-hxxizipk | Using a controlled method of viral inoculation allows us to standardize inoculation dose so we can ask, given equal exposure, how does temperature affect the ability of a pathogen to persist and replicate in a given host? |
| cord-290253-hxxizipk | the key to understanding host- pathogen interactions and microbial pest control? |
| cord-346053-mk1mzc5z | How can we make sense of the processes that have led to the wide variety of pathogenicity factors in plant pathogens and that continue to drive the evolution of pathogens? |
| cord-346053-mk1mzc5z | How do pathogens, whether they parasitize plants or animals, acquire virulence to new hosts and resistance to the arms we deploy to control disease? |
| cord-346053-mk1mzc5z | The ABC transporter BcatrB affects the sensitivity of Botrytis cinerea to the phytoalexin resveratol and the fungicide fenpiclonil Pathogenicity genes of phytopathogenic fungi Fungal LysM effectors: extinguishers of host immunity? |
| cord-346053-mk1mzc5z | The importance of fungal pectinolytic enzymes in plant invasion, host adaptability and symptom type Pathogenic fungi: leading or led by ambient pH? |
| cord-346053-mk1mzc5z | gypsophilae and betae, recently evolved pathogens? |
| cord-334315-ymkrgj0h | Can viruses also influence host transcription by manipulating RNA decay pathways to short- circuit feedback regulatory mechanisms? |
| cord-334315-ymkrgj0h | Could sfRNAmediated inactivation of Xrn1 cause a defect in the coordination of RNA decay and transcription in the host? |
| cord-334315-ymkrgj0h | How do virusinduced changes in RNA decay pathways interface with potential changes in innate immune responses? |
| cord-334315-ymkrgj0h | How might changes in host mRNA stability contribute to virus- induced pathology during infection( Figure 1)? |
| cord-334315-ymkrgj0h | What are the consequences of viral inactivation of decay factors like Xrn1 in terms of disease? |
| cord-332205-ydijp66b | Can you believe that there is not even a unified database for viruses? |
| cord-332205-ydijp66b | Can you imagine that nearly all existing bioinformatical tools are not specifically designed for the context of viruses? |
| cord-332205-ydijp66b | Did you know that virologists currently only know of about 3,200 viral species but that more than 320,000 mammal- associated viruses[ 4] are thought to await discovery? |
| cord-332205-ydijp66b | Global transport networks and infectious disease spread Natural alternatives to in- feed antibiotics in pig production: can immunomodulators play a role? |
| cord-332205-ydijp66b | Interested? |
| cord-332205-ydijp66b | Perhaps there was no time left to take care of viruses? |
| cord-332205-ydijp66b | Why is this? |