trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
the presence of	286
as well as	197
in the presence	174
the development of	166
one of the	164
the use of	159
of cathepsin l	148
the formation of	147
the treatment of	140
based on the	125
according to the	123
due to the	116
as shown in	114
the effect of	107
the synthesis of	105
shown in figure	101
in order to	94
structure of the	90
on the other	89
the other hand	89
the case of	87
the eo of	87
in the case	85
for the treatment	84
the active site	81
in vitro and	79
of the virus	78
was used to	78
a series of	75
formyl peptide receptor	75
severe acute respiratory	74
the activity of	74
compared to the	73
the concentration of	72
found to be	72
human immunodeficiency virus	72
the structure of	71
acute respiratory syndrome	71
involved in the	70
was found to	69
the production of	68
in addition to	66
in the eo	64
the expression of	64
in this study	64
vitro and in	64
of biscao water	63
the role of	62
of the compounds	61
the activation of	60
a number of	60
and in vivo	60
antiviral activity of	59
used as a	59
cathepsin l and	58
to determine the	57
are shown in	57
the mechanism of	56
the interaction of	55
was added to	55
herpes simplex virus	55
cancer cell lines	55
most of the	55
the authors declare	55
responsible for the	54
no conflict of	54
of the target	54
related to the	54
can be used	54
declare no conflict	53
used in the	53
conflict of interest	53
authors declare no	53
the surface of	53
at room temperature	53
in the range	53
the number of	53
respiratory syncytial virus	52
crystal structure of	52
compared with the	52
is one of	52
of the protein	51
in drug discovery	51
the binding of	51
of the most	50
the antiviral activity	50
and cathepsin l	49
of these compounds	49
the p a	49
used for the	49
was treated with	49
lb and sb	48
for the development	48
binding to the	48
showed that the	48
the range of	48
and characterization of	48
the analysis of	47
for the synthesis	47
coli topoisomerase i	47
of the enzyme	47
of the sars	47
activity of the	46
cov cl pro	46
be used to	46
well as the	46
tc and cf	45
for peer review	45
x for peer	45
hepatitis c virus	45
peer review of	45
mechanism for the	45
such as the	44
to give compound	44
the identification of	44
of the ligand	44
amino acid residues	43
in the treatment	43
it has been	43
a variety of	43
led to the	43
the inhibition of	43
were used as	43
to be a	43
in patients with	43
has been reported	43
autophagic cell death	42
the effects of	42
traditional chinese medicine	42
the most potent	42
role in the	42
was carried out	42
some of the	42
due to its	41
and colloidal dispersion	41
binding energy of	41
have been reported	41
the absence of	40
and then purified	40
in which the	40
analysis of the	40
chromatography to give	40
the release of	40
then purified by	40
shown in table	40
in figure a	40
this class of	40
of silver nanoparticles	40
the design of	40
effect of the	40
presence of a	39
with respect to	39
that can be	39
the s pocket	39
the first step	39
activation of the	39
the results of	39
in vitro selection	39
of wild hemp	39
ic values of	39
proposed mechanism for	38
the creative commons	38
the desired product	38
the cells were	38
the present study	38
obtained from the	38
surface of the	38
position of the	38
the terms and	38
of the creative	38
and conditions of	38
terms and conditions	38
on the surface	38
under the terms	38
dna and rna	38
conditions of the	38
creative commons attribution	38
breast cancer cells	38
to the general	38
the general procedure	38
in the first	37
with ic values	37
by column chromatography	37
because of the	37
to evaluate the	37
the discovery of	37
a and b	37
as a result	37
in drug design	37
in complex with	37
the importance of	37
at the same	36
in the s	36
by reverse phase	36
the efficacy of	36
phase flash chromatography	36
the application of	36
to give the	36
reverse phase flash	36
class of inhibitors	36
this article is	36
inhibitors of tmprss	36
the most active	35
present in the	35
was used as	35
the crystal structure	35
respiratory syndrome coronavirus	35
general procedure a	35
purified by reverse	35
in terms of	35
the addition of	35
nuclear magnetic resonance	35
an open access	34
the host cell	34
wide range of	34
open access article	34
the fact that	34
type ia topoisomerases	34
distributed under the	34
tmprss and cathepsin	34
is an open	34
in the second	34
article is an	34
flash chromatography to	34
the amount of	34
in this review	34
access article distributed	34
of the p	34
article distributed under	34
been reported to	34
predicted by swissadme	34
of dna aptamers	34
the s subsite	33
a mixture of	33
added to the	33
has been used	33
eo of wild	33
porphyrins and their	33
of cancer cells	33
which is a	33
have shown that	33
when compared to	33
to form the	33
results showed that	33
have been used	33
and their analogues	33
of a novel	33
of the main	33
human cathepsin l	32
to improve the	32
of the viral	32
to the formation	32
synthesis of phosphoramidates	32
and in vitro	32
d and d	32
the scope of	32
in the development	32
in combination with	32
to afford the	31
associated with the	31
l and b	31
studies on the	31
based drug design	31
mechanism of the	31
formation of the	31
used as the	31
were carried out	31
revealed that the	31
were found to	31
with an ic	31
c for h	31
the introduction of	31
to enhance the	31
inhibitors of cathepsin	31
observed in the	30
was purified by	30
ic value of	30
effect on the	30
contribute to the	30
a set of	30
interactions with the	30
were used to	30
in the present	30
indicated that the	30
suggested that the	30
bind to the	30
influenza a virus	30
simplex virus type	30
the interaction between	30
the second step	30
has also been	30
to inhibit the	30
reactive oxygen species	30
is able to	29
the most common	29
an important role	29
large number of	29
s and s	29
inhibition of the	29
eo of the	29
the potential of	29
reported in the	29
synthesis and biological	29
the detection of	29
the mixture was	29
a wide range	29
to that of	28
form hydrogen bonds	28
presence of the	28
important role in	28
the structures of	28
cathepsin l in	28
a large number	28
cells in vitro	28
predicted by vnnadmet	28
of compounds a	28
deep eutectic solvents	28
studies have shown	28
and evaluation of	28
in the last	27
hydrogen bonds with	27
for h at	27
to form a	27
is the most	27
dpph radical scavenging	27
in the field	27
in recent years	27
inhibitory effect on	27
c and c	27
of human cathepsin	27
of the reaction	27
been found to	27
treated with n	27
of the n	27
of the total	27
immunodeficiency virus type	27
to increase the	27
based virtual screening	27
were able to	27
selectivity over cathepsin	27
e and a	27
of patchouli alcohol	26
mechanism of action	26
the search for	26
west nile virus	26
results indicated that	26
of tmprss and	26
for min at	26
hydrogen bonds or	26
have also been	26
mechanisms of action	26
at the s	26
the immune system	26
concentration of the	26
in the same	26
is involved in	26
in a dose	26
be used for	26
the ph of	26
active site of	26
to the target	26
can also be	25
as a potential	25
the combination of	25
the process of	25
scsio xws f	25
fpr and fpr	25
of the two	25
the field of	25
nmr spectra of	25
resulting in the	25
spectra were recorded	25
the binding site	25
the viral envelope	25
of influenza virus	25
there is a	25
the growth of	25
over cathepsin b	25
been used as	25
of the c	25
based on their	25
purified by column	25
the percentage of	25
synthesis of p	25
in the search	25
study of the	25
is associated with	25
evaluation of the	25
cancer cells and	25
the molecular mechanisms	24
it can be	24
following treatment with	24
the same time	24
biscao water was	24
in the process	24
the amino acid	24
cathepsin l with	24
when compared with	24
properties of the	24
increase in the	24
of compound a	24
the best docked	24
based drug discovery	24
based analytical devices	24
is shown in	24
of the binding	24
are involved in	24
the n gene	24
the possibility of	24
results in the	24
in the formation	24
was used for	24
recent advances in	24
attributed to the	24
of the eo	24
depending on the	24
that have been	24
cell death in	24
atom of the	24
the reaction mixture	23
of action of	23
phytochemical inhibitors of	23
shown in scheme	23
biscao water and	23
stacking interactions with	23
hydrogen bond with	23
for cathepsin l	23
against hepg cells	23
the intensity of	23
been reported in	23
been used for	23
dependent rna polymerase	23
a total of	23
reported to be	23
in comparison with	23
it is also	23
followed by the	23
the end of	23
and can be	23
the area of	23
formyl peptide receptors	23
interaction with the	23
the results indicated	23
has been widely	23
in response to	22
the ability to	22
the performance of	22
the effectiveness of	22
formation of a	22
is an important	22
in agreement with	22
towards cathepsin l	22
binding of the	22
to uv light	22
scope of the	22
development of a	22
is used to	22
found that the	22
type ia topoisomerase	22
antiviral activity against	22
inhibitor predicted by	22
which can be	22
compound was treated	22
in the literature	22
in the absence	22
a recent study	22
these compounds were	22
values of the	22
it is a	22
use of a	22
growth factor receptor	22
to investigate the	22
been shown to	22
spectra of the	22
be used as	22
is responsible for	22
the detection limit	22
the basis of	22
tumor necrosis factor	22
ns to ns	22
the ability of	22
the most promising	22
leads to the	22
a concentration of	22
t and t	22
of metal nanoparticles	21
in this work	21
and biological evaluation	21
need to be	21
in cancer therapy	21
have been identified	21
forms hydrophobic contacts	21
of the antioxidant	21
and in the	21
relative to the	21
the target protein	21
were treated with	21
the crude product	21
to be the	21
the values of	21
the mechanisms of	21
in a recent	21
the induction of	21
hepg cells and	21
isolated from the	21
to study the	21
residues that form	21
by means of	21
expressed as the	21
on the basis	21
of the compound	21
the function of	21
of a new	21
to assess the	21
hydrophobic contacts with	21
the results showed	21
sequence of the	21
structures of the	21
no effect on	21
of the active	21
that form hydrogen	21
the pathogenesis of	21
after oral administration	21
best docked pose	21
for the design	21
a solution of	21
in this case	21
in breast cancer	21
for drug discovery	20
compounds have been	20
found in the	20
cells were seeded	20
the generation of	20
cells treated with	20
as the mean	20
contacts with residues	20
three independent experiments	20
at the p	20
been used to	20
the nature of	20
type hydrogen bond	20
characterization of a	20
potent and selective	20
with that of	20
of the inhibitor	20
mediated synthesis of	20
due to their	20
the md simulation	20
of human immunodeficiency	20
of this class	20
prepared compounds were	20
an increase in	20
considered to be	20
as a consequence	20
the lack of	20
in ewat of	20
acts as a	20
mediated isothermal amplification	20
the formyl peptide	20
of severe acute	20
cells and mcf	20
o type hydrogen	20
leading to the	20
it should be	20
intensity of the	20
a review of	20
hepatitis b virus	20
diseases such as	20
the influence of	20
inhibitors of the	20
the evaluation of	20
biological evaluation of	20
in another study	20
together with the	20
at a concentration	20
similar to that	19
suggest that the	19
for c h	19
of the s	19
product was purified	19
the extraction of	19
on a bruker	19
of bioactive compounds	19
were recorded on	19
of the cell	19
the cathepsin l	19
to reduce the	19
the content of	19
widely used in	19
silica gel column	19
lead to the	19
the stability of	19
have been developed	19
of natural products	19
than that of	19
patients with severe	19
the reference compounds	19
of autophagy in	19
of the peptide	19
the levels of	19
are listed in	19
addition to the	19
in a mouse	19
comfa and comsia	19
site of the	19
could be used	19
can lead to	19
the binding affinity	19
suggesting that the	19
production of il	19
drug discovery and	19
similar to the	19
in the lungs	19
results revealed that	19
it is worth	19
the administration of	19
of the same	19
each of the	19
correspond to the	19
is based on	19
the indole ring	19
members of the	19
the specificity of	19
which may be	19
of the hiv	19
the proliferation of	19
expression of the	19
is essential for	19
of rnai molecules	19
interaction between the	19
corresponding to the	19
the binding pocket	19
inhibitory activity of	18
of the human	18
a positive control	18
simultaneous detection of	18
point of view	18
was reported to	18
was determined by	18
carried out on	18
after h of	18
detection of multiple	18
were obtained from	18
antioxidant activity of	18
the reduction of	18
changes in the	18
atoms of the	18
central nervous system	18
a mouse model	18
are expressed as	18
for the detection	18
for the first	18
and its derivatives	18
of aconitine alkaloids	18
of p a	18
epa or ht	18
pi k akt	18
of ac with	18
is required for	18
in biscao water	18
the in vitro	18
supplementary tables s	18
it is possible	18
binds to the	18
in the future	18
antibacterial activity of	18
the reaction of	18
demonstrated that the	18
for h and	18
derived from the	18
the cell membrane	18
of the g	18
the reaction was	18
of the drug	18
the determination of	18
the most important	18
was subjected to	18
room temperature for	18
and molecular modeling	18
used in this	18
binding energies of	18
included in the	18
structural basis for	18
the eos of	18
the distance between	18
in the usa	18
chemical constituents of	18
the screening of	18
in the active	18
supplementary figure s	18
to be used	18
the breeding lines	18
to the development	18
for the extraction	18
information on the	18
were performed in	18
are summarized in	17
the standard drug	17
in comparison to	17
indian medicinal plants	17
in the form	17
the progression of	17
mode of action	17
as in the	17
indicate that the	17
virtual screening and	17
with cathepsin l	17
to interact with	17
the form of	17
recorded on a	17
it was shown	17
the authors of	17
determined by the	17
the p site	17
be attributed to	17
presence of an	17
a binding energy	17
data not shown	17
chemical constituents from	17
sar by nmr	17
were subjected to	17
binding site of	17
been used in	17
that of the	17
shift of the	17
based on a	17
reaction mixture was	17
a result of	17
after treatment with	17
bound to the	17
an ic value	17
de novo design	17
is important to	17
of amino acid	17
well as in	17
the sensitivity of	17
compounds were evaluated	17
a library of	17
a decrease in	17
in the crystal	17
supplementary table s	17
been widely used	17
are responsible for	17
of the corresponding	17
essential for the	17
strain scsio xws	17
the selection of	17
complex with the	17
potential inhibitors of	17
trypsin inhibitory activity	17
of essential oils	17
depends on the	17
for drug design	17
inhibitory effect of	17
has been shown	17
a critical role	17
the registered cultivars	17
the inhibitory effect	17
epidermal growth factor	17
the ic values	17
was shown that	17
b and c	17
of influenza a	17
of the gp	17
and molecular docking	17
has been found	17
crude product was	17
activity of some	17
region of the	17
serum amyloid a	17
to bind to	17
effects on the	17
in the c	17
were added to	17
cancer cells in	17
of all the	17
used to determine	16
did not show	16
is due to	16
the need for	16
which is the	16
gastric cancer cells	16
and drug administration	16
the results obtained	16
of amino acids	16
time of addition	16
there is no	16
vitro selection of	16
of the herb	16
apoptosis and autophagy	16
in the synthesis	16
colon cancer cells	16
an example of	16
the affinity of	16
of a protein	16
as an example	16
with the target	16
features of the	16
for use in	16
it is well	16
in the human	16
interaction of ac	16
discovery and development	16
and sb methods	16
comparison of the	16
was evaluated by	16
of the synthesis	16
the positive control	16
both in vitro	16
and to the	16
of traditional chinese	16
part of the	16
oral administration of	16
the interaction with	16
carried out using	16
without the need	16
the virus and	16
analysis was performed	16
cell lung cancer	16
free energy calculations	16
rna topoisomerase activity	16
a dna aptamer	16
endothelial growth factor	16
the phosphorylation of	16
to confirm the	16
results of the	16
the type of	16
virtual screening of	16
also known as	16
group at the	16
has a binding	16
at position of	16
are able to	16
use of the	16
in the airways	16
and b in	16
of the substrate	16
nmr spectra were	16
to predict the	16
it is important	16
determination of the	16
ac with naoh	16
results suggest that	16
stability of the	16
a panel of	16
the course of	16
be used in	16
in vitro anti	16
the regulation of	16
led to a	16
development of new	16
the compounds were	16
proved to be	16
in this context	16
decrease in the	16
the recognition of	16
food and drug	16
a role in	15
as the reference	15
the amine to	15
in the study	15
cathepsin b and	15
the nlrp inflammasome	15
end of the	15
in vivo studies	15
in cancer cells	15
to obtain a	15
mouth disease virus	15
the results revealed	15
was observed in	15
these derivatives were	15
ic values in	15
to be an	15
in the current	15
was measured using	15
at the end	15
cathepsin l residues	15
effects of the	15
the result of	15
resulting in a	15
a consequence of	15
the plates were	15
in rat plasma	15
and synthesis of	15
as inhibitors of	15
at the active	15
molecular mechanisms of	15
antiviral activities of	15
the virus to	15
is the first	15
performance liquid chromatography	15
by using a	15
biscao and bisca	15
of the host	15
inhibitor of cathepsin	15
was reported by	15
sites of the	15
of nucleic acids	15
alanine and then	15
for the identification	15
is noteworthy that	15
the cell viability	15
reported to have	15
the constituents of	15
the work of	15
the chemical structure	15
nature of the	15
wang et al	15
critical role in	15
and development of	15
to be effective	15
have been proposed	15
the death of	15
also been reported	15
is similar to	15
of this series	15
with the corresponding	15
molecular dynamics simulations	15
epa and ht	15
it is not	15
the antibacterial activity	15
of the chemical	15
cannabis sativa l	15
early stages of	15
summarized in table	15
isolated yields of	15
it is noteworthy	15
the study of	15
the metal ion	15
antioxidant capacity of	15
because of their	15
the prediction of	15
have been found	15
the anomeric proton	15
the results are	15
on the viral	15
the same trend	15
was the most	15
of proteins and	15
also been used	15
in vivo and	15
activity against the	15
of the products	15
reaction of the	15
of the breeding	15
cancer cell line	15
the stage of	15
were purchased from	15
that bind to	15
the action of	15
in the protein	14
understanding of the	14
of the structure	14
fusion of the	14
inhibition zone of	14
the spectra of	14
based analytical device	14
detection limit of	14
substrate binding residue	14
which is an	14
ability of the	14
ranging from to	14
activity of a	14
below the detection	14
vesicular stomatitis virus	14
is well known	14
an in vitro	14
it was observed	14
are needed to	14
a key role	14
bu n br	14
small interfering rna	14
cells in the	14
was prepared by	14
of the test	14
based on these	14
to the standard	14
this is the	14
group of the	14
dipolar cycloaddition of	14
as a new	14
the hcv protease	14
world health organization	14
as a positive	14
that has been	14
the synthesis was	14
bean trypsin inhibitor	14
the test compounds	14
identification of a	14
dna aptamers are	14
of hepatitis c	14
the viral genome	14
is composed of	14
drug design and	14
the roles of	14
different types of	14
antibacterial and antifungal	14
a class of	14
deep eutectic solvent	14
all of these	14
terminal domains of	14
c in a	14
for the analysis	14
the rnai molecules	14
the center of	14
was expressed as	14
proteins in the	14
dna topoisomerase i	14
is that the	14
in view of	14
breast cancer cell	14
were used for	14
interacting with the	14
the results were	14
obstructive pulmonary disease	14
the replication of	14
extracted from the	14
cell proliferation and	14
the influenza virus	14
molecular docking studies	14
were identified as	14
of the registered	14
the amino acids	14
structure of a	14
the binding energy	14
reported that the	14
of gold nanoparticles	14
activity against hepg	14
in the binding	14
the synthesis and	14
the preparation of	14
cf remained viable	14
in the pathogenesis	14
is determined by	14
new series of	14
distance between the	14
cfu ml of	14
also be used	14
response surface methodology	14
type hydrogen bonds	14
inhibitors of human	14
of type ia	14
induction of autophagy	14
chronic obstructive pulmonary	14
gel column chromatography	14
values in the	14
activated protein kinase	14
was identified as	14
to be more	14
it was found	14
of n gene	14
using the same	14
in prostate cancer	14
ns of the	14
that in the	14
is consistent with	14
has not been	14
play an important	14
a tcm formula	14
the results from	14
is related to	14
some of these	14
along with the	14
and incubated at	14
interact with the	14
instead of the	14
lower than the	14
the aim of	14
acute lung injury	14
design and synthesis	14
incubated for h	14
study on the	14
the cytotoxicity of	14
proliferative activity against	14
specificity of the	14
the method was	14
mouse model of	14
spectra of ac	14
were evaluated against	14
of the three	14
dna aptamers have	13
effect of mizoribine	13
aptamers have been	13
in the host	13
under reduced pressure	13
mg kg day	13
been reported that	13
an inhibitor of	13
was performed by	13
previous studies have	13
in clinical trials	13
of drug discovery	13
the first time	13
therapeutic potential of	13
used to identify	13
in most cases	13
the rate of	13
and molecular dynamics	13
the isolation of	13
formed in the	13
were in the	13
identification of novel	13
view of the	13
the delivery of	13
ewat of hfd	13
modification of the	13
of escherichia coli	13
more potent than	13
antiviral effect of	13
the s site	13
cd t cells	13
by increasing the	13
of the molecules	13
chemical structure of	13
the wild hemp	13
de novo drug	13
required for the	13
development of novel	13
of the ir	13
binding affinity of	13
d structure of	13
lower than that	13
by silica gel	13
in the following	13
which has been	13
of these derivatives	13
and that the	13
then subjected to	13
of the antiviral	13
bioshell calcium oxide	13
the chemical shift	13
a wide variety	13
result of the	13
are essential for	13
to the synthesis	13
of the ple	13
by nmr spectroscopy	13
period of time	13
inhibitory activity against	13
and subjected to	13
structure of tmprss	13
respect to the	13
protein data bank	13
herbal medicine and	13
of compounds with	13
in the best	13
the main protease	13
at and cm	13
in the h	13
of the pyrazole	13
of herpes simplex	13
key role in	13
the ic value	13
is mediated by	13
inflammatory and anti	13
the antioxidant activity	13
the supernatant was	13
relies on the	13
was performed using	13
the prepared compounds	13
to verify the	13
potency and selectivity	13
the d structure	13
the management of	13
of the disease	13
a reaction of	13
and treatment of	13
energy of the	13
indicating that the	13
review of the	13
in this respect	13
wide variety of	13
were prepared by	13
and has been	13
of the tested	13
for the use	13
van der waals	13
were determined by	13
caused by the	13
the ratio of	13
of small molecules	13
to understand the	13
cells were washed	13
stages of the	13
in the lung	13
that the presence	13
cells were then	13
in accordance with	13
this method was	13
in a similar	13
the existence of	13
the porphyrins and	13
mrna levels of	13
toward cathepsin l	13
of the md	13
the most relevant	13
in the regulation	13
this type of	13
uv light for	13
carried out in	13
a colorless amorphous	13
of tc and	13
colorless amorphous solid	13
to form an	13
leads to a	13
and its application	13
chen et al	13
that most of	13
the time of	13
were selected for	13
based microfluidic devices	13
multiplexed detection of	13
of the selected	13
molecular docking and	13
and virtual screening	13
of the amino	13
protein in the	13
as indicated in	13
small cell lung	13
these compounds are	13
positive and gram	13
potent inhibitors of	13
to the lungs	13
the removal of	13
vascular endothelial growth	13
the control group	13
of this review	13
are required for	13
with high affinity	13
the search of	13
implicated in the	13
of the interaction	13
on the constituents	12
was found that	12
the complement system	12
are found in	12
fusion with the	12
natural deep eutectic	12
cimicifuga simplex wormsk	12
we found that	12
the cfu ml	12
was determined using	12
inflammatory activity of	12
were performed using	12
of biological activities	12
in the free	12
novo drug design	12
indicates that the	12
of cysteine cathepsins	12
should be noted	12
an in silico	12
detected in the	12
to the cell	12
the binding mode	12
as compared to	12
of the series	12
cells with ic	12
topoisomerase i and	12
role of autophagy	12
treatment of covid	12
properties of a	12
the leaves of	12
the lungs of	12
to explore the	12
derived growth factor	12
phage display technology	12
position in the	12
was based on	12
and cf remained	12
ex vivo selection	12
been developed to	12
of harringtonine was	12
values ranging from	12
antimicrobial activity of	12
purified by silica	12
reduction of the	12
both cathepsin l	12
found to have	12
identification of potential	12
active cathepsin l	12
correlation peaks between	12
the emergence of	12
is worth noting	12
a combination of	12
an ic of	12
cells were treated	12
cathepsin l is	12
in a concentration	12
the antiviral efficacy	12
for patients with	12
gold bean trypsin	12
the phenyl ring	12
the free ligand	12
role of the	12
compounds of series	12
have led to	12
other members of	12
the early stages	12
insight into the	12
in the spectra	12
is formed in	12
a group of	12
and it is	12
in figure b	12
and the corresponding	12
isolation and characterization	12
are presented as	12
bovine serum albumin	12
were incubated with	12
the interactions between	12
constituents of cimicifuga	12
in figure c	12
kcal mol and	12
basis for the	12
contributes to the	12
saturation transfer difference	12
goitrin and s	12
inflammatory cytokines and	12
the ple band	12
activities of the	12
resulted in the	12
bond with the	12
be noted that	12
cfu ml for	12
can be a	12
method for the	12
rsv f protein	12
be due to	12
the rpi data	12
the cell surface	12
has been proposed	12
interacts with the	12
and the cell	12
has been demonstrated	12
by the presence	12
showed the highest	12
the ppi network	12
in crude drugs	12
small molecule inhibitors	12
as previously reported	12
in the reaction	12
different concentrations of	12
are associated with	12
the site of	12
was developed using	12
to the control	12
in the intensity	12
case of the	12
chemical shift of	12
treatment with undiluted	12
treatment with a	12
area of the	12
was incubated with	12
and granules of	12
tuberculosis topoisomerase i	12
a systematic review	12
of a single	12
was utilized to	12
of the paper	12
prostate cancer cells	12
the spread of	12
and the subsequent	12
in the culture	12
to the active	12
has led to	12
the simultaneous detection	12
series of compounds	12
specificity and sensitivity	12
aerial parts of	12
developed a series	12
to of the	12
introduction of a	12
attached to the	12
molecular mass of	12
studies of the	12
fold selectivity over	12
the substrate binding	12
the carbon atoms	12
tandem mass spectrometry	12
ppm for c	12
of cancer cell	12
rpi data set	12
to each well	12
of sars coronavirus	12
identified as a	12
molecular mechanism of	12
gold nanoparticles were	12
crystal structures of	12
from the authors	12
of the first	12
have already been	12
in the control	12
temperature for min	12
compared to those	12
listed in table	12
the quality of	12
of the indole	12
in a humidified	12
standard deviation of	12
patchouli alcohol was	12
this scaffold was	12
for the reaction	12
in the target	12
was performed in	12
the roots of	12
a bruker avance	12
c for min	12
results are presented	12
s pocket of	12
information about the	12
in the n	12
influence on the	12
for binding to	12
using the coreldraw	11
representation of the	11
in traditional chinese	11
the majority of	11
synthesis of new	11
substituents on the	11
and coworkers prepared	11
correlation of h	11
substituents at the	11
selectivity towards cathepsin	11
the developed compound	11
of rgdechi d	11
types of cancer	11
in the fight	11
the aconitine alkaloids	11
human breast cancer	11
is a potent	11
molecule inhibitors of	11
expression levels of	11
added to each	11
of the results	11
are related to	11
to the anti	11
of the complexes	11
shown that the	11
the coreldraw software	11
are capable of	11
with or without	11
xws f was	11
in this regard	11
shown to be	11
the benzoxazine ring	11
cytokines and chemokines	11
of zikv infection	11
mixture was stirred	11
consistent with the	11
agreement with the	11
in the production	11
of a series	11
cathepsin l biology	11
r r r	11
do not have	11
specific for the	11
to obtain the	11
in safa m	11
l residues that	11
of patients with	11
of a drug	11
can be found	11
transforming growth factor	11
use of metal	11
respiratory distress syndrome	11
is possible to	11
fetal bovine serum	11
is also a	11
able to inhibit	11
ability to inhibit	11
delivery of sirna	11
design of a	11
as a novel	11
the plasma membrane	11
of the manuscript	11
the rgdechi d	11
involves the formation	11
p a to	11
image was developed	11
studies have reported	11
acute respiratory distress	11
these prepared compounds	11
in the viral	11
interactions with c	11
crude products were	11
regulation of autophagy	11
the template surface	11
h at room	11
give the desired	11
the rest of	11
the isoxazolidine ring	11
the potential to	11
western blot analysis	11
on the interaction	11
of the usa	11
out to be	11
and the reaction	11
synthesis of a	11
the target of	11
is found in	11
the samples were	11
and dpph radical	11
was calculated as	11
to perform a	11
patients with covid	11
discovery of novel	11
a measure of	11
biological activity of	11
they do not	11
compounds in the	11
hydrogen bond formation	11
this compound was	11
of more than	11
plates were incubated	11
for min and	11
amino acid sequences	11
binding free energy	11
in the cell	11
epa plus ht	11
selective inhibitor of	11
nuclear overhauser effect	11
and sodium acetate	11
was also used	11
afford the desired	11
and tcm formulas	11
of the sample	11
and identification of	11
as demonstrated by	11
in the work	11
change in the	11
synthesis and evaluation	11
synthesis of novel	11
and of the	11
insights into the	11
induced by the	11
as a control	11
is important for	11
of isoxazolidines cis	11
focused on the	11
this image was	11
to identify the	11
on silica gel	11
catalyzed oxidative cross	11
interactions between the	11
to measure the	11
exposure to uv	11
coli dna topoisomerase	11
of the catalytic	11
the need to	11
the secretion of	11
the side chain	11
of roselle calyces	11
the availability of	11
with the cell	11
to synthesize p	11
utilized for the	11
of phenolic compounds	11
for this purpose	11
an amino acid	11
has been proven	11
to detect the	11
cathepsin l enzyme	11
at the early	11
of cimicifuga species	11
binding pocket of	11
the level of	11
the solvent was	11
n and h	11
the rate constants	11
could be a	11
proven to be	11
rest of the	11
in cathepsin l	11
these results suggest	11
in contrast to	11
trypsin inhibitor is	11
showed ic values	11
side chain of	11
cell viability was	11
concentration in the	11
the control of	11
against influenza a	11
the training set	11
carbon atoms of	11
cells were incubated	11
of ligand binding	11
they found that	11
was isolated from	11
of h o	11
to provide a	11
worth noting that	11
figure s a	11
ph of biscao	11
approved by the	11
to screen the	11
and formic acid	11
removal of the	11
to cathepsin l	11
exposed to uv	11
corel corporation id	11
on the structure	11
of some new	11
t forms hydrophobic	11
of dna and	11
medicine and tcm	11
and have been	11
with severe covid	11
designed and synthesized	11
and incubated for	11
was obtained from	11
with the aim	11
characterization of the	11
was purchased from	11
developed using the	11
shows the cathepsin	11
of the metal	11
been proposed to	11
were the most	11
consists of two	11
usa hemp strain	11
docked pose with	11
was shown to	11
an overview of	11
to analyze the	11
the antioxidant capacity	11
cancer cells by	11
by measuring the	10
a sodium voltage	10
note that the	10
in traditional medicine	10
of virtual screening	10
compounds such as	10
to have anti	10
bonds with residues	10
the tmprss residues	10
docking and molecular	10
relaxation edited nmr	10
reacts with the	10
will be discussed	10
virus and the	10
be responsible for	10
well as for	10
cathepsin l over	10
were infected with	10
light for min	10
to the best	10
influenza a viruses	10
the silver nanoparticles	10
treated with the	10
the last years	10
of apoptotic cells	10
of the individual	10
herbs and tcm	10
virtual screening is	10
and use of	10
a molecular mass	10
was performed with	10
there is an	10
autophagy and apoptosis	10
rgdechi d peptide	10
by the authors	10
incubated with the	10
in line with	10
induced autophagic cell	10
are the main	10
to the cells	10
the concept of	10
synthesis was explored	10
the molecular docking	10
at the para	10
co in the	10
this study was	10
any of the	10
research groups have	10
a new series	10
the protein and	10
c forms hydrophobic	10
in the low	10
was performed on	10
new class of	10
to compare the	10
vein endothelial cells	10
considered as a	10
used in traditional	10
member of the	10
of reactive oxygen	10
were determined using	10
fact that the	10
the last few	10
of the virion	10
in vitro evaluation	10
effect of umifenovir	10
vero e cells	10
molecular similarity and	10
targets for the	10
of the isoxazolidine	10
afforded the target	10
isomeric pyrazolyl nucleosides	10
can interact with	10
and function of	10
and antiviral activity	10
and h n	10
properties such as	10
was prepared in	10
remained viable following	10
semen ziziphi spinosae	10
as a catalyst	10
coated silver nanoparticles	10
by reversible exchange	10
a model of	10
be related to	10
the inhibitory activity	10
of carbon atoms	10
component of the	10
with a low	10
an anticancer drug	10
the most effective	10
number of studies	10
and quantification of	10
staphylococcus aureus and	10
advances in the	10
be associated with	10
carried out by	10
and stored at	10
wealth of india	10
structural features of	10
play a role	10
to carry out	10
addition of the	10
to prevent the	10
and activation of	10
has been described	10
increase of the	10
similar to those	10
interactions with t	10
inhibitory effects on	10
the natural compounds	10
amino acid groups	10
the aid of	10
methods in drug	10
of viral infection	10
ml for tc	10
to reduce virus	10
of active molecules	10
in a follow	10
of the isomeric	10
solvent was removed	10
the selected compounds	10
activities of biscao	10
the united states	10
is a major	10
gated channel type	10
may not be	10
of cimicifuga simplex	10
comparison to the	10
used to screen	10
of small molecule	10
was determined as	10
activation of caspase	10
the wealth of	10
polymerase chain reaction	10
the loss of	10
selectivity of the	10
that biscao water	10
substitution of the	10
the target products	10
through inhibition of	10
additional water and	10
c is a	10
permission from the	10
by using the	10
and safety of	10
route to p	10
components of the	10
this indicates that	10
was observed that	10
the drug discovery	10
carbonyl group at	10
tmprss residues that	10
the fusion of	10
against herpes simplex	10
the least potent	10
a novel coronavirus	10
structure of human	10
control of the	10
size of the	10
viable following treatment	10
to the host	10
found to inhibit	10
of the molecule	10
the significance of	10
with an ec	10
released from the	10
the aerial parts	10
the value of	10
bacterial topoisomerase i	10
umbilical vein endothelial	10
class of compounds	10
antimicrobial activity against	10
higher than that	10
different stages of	10
for the production	10
inhibitors of sars	10
from the amine	10
be found in	10
inhibitory effects of	10
amino acid sequence	10
of mass of	10
magnetic resonance spectroscopy	10
about ppm for	10
amine to give	10
in hepg cells	10
light of the	10
gene expression of	10
n and n	10
the exception of	10
h n and	10
nmr spectroscopy and	10
p and p	10
cleavage of the	10
a comparison of	10
at the beginning	10
linked to the	10
used to evaluate	10
a review on	10
in this paper	10
of the nlrp	10
important for the	10
such as a	10
a mechanism of	10
essential oils from	10
the target compounds	10
routes to p	10
in the nanomolar	10
model of the	10
of the complex	10
for the simultaneous	10
of this compound	10
it is the	10
with the aid	10
of series i	10
scn a sodium	10
n gene expression	10
analogous to that	10
c h o	10
the ns b	10
the antiviral effect	10
the activities of	10
consists of a	10
reported on the	10
into host cells	10
granules of r	10
basis of the	10
the nanomolar range	10
was able to	10
various types of	10
the usa hemp	10
efficacy and safety	10
gold nanoparticles as	10
for the recognition	10
domain of the	10
and antimicrobial activity	10
of new drugs	10
with permission from	10
amino acids at	10
interfere with the	10
the polarization transfer	10
associated with a	10
have not been	10
may also be	10
a and trans	10
h and c	10
human umbilical vein	10
antiviral efficacy of	10
between the aromatic	10
synthesis of compounds	10
inhibition zones of	10
the university of	10
the genetic material	10
presented in table	10
has been developed	10
was used in	10
a change in	10
peripheral blood mononuclear	10
shows the tmprss	10
of cytochrome c	10
can be observed	10
radix salviae miltiorrhizae	10
structural models of	10
likely to be	10
injected into the	10
bioinformatics and molecular	10
the sequence of	10
binding energy in	10
for tc and	10
p a and	10
n synthesis via	10
of in vitro	10
of the h	10
of tcm formulas	10
the human immunodeficiency	10
well as their	10
the risk of	10
cells at the	10
gold nanoparticles in	10
activity of mizoribine	10
to give a	10
the fight against	10
design of new	10
the hydroxyl group	10
scope of this	10
be a promising	10
this means that	10
response to the	10
the rpirls method	10
and biological activity	10
to a solution	10
the isomeric pyrazolyl	10
signal amplification by	10
influenza virus infection	10
was stirred at	10
is a natural	10
generated by the	10
von willebrand factor	10
frap and dpph	10
formation of an	10
inhibitor of the	10
in the dark	10
cell death of	10
with the exception	10
interactions of the	10
and the ph	10
of cathepsin k	10
from ns to	10
amplification by reversible	10
a powerful tool	10
this is a	10
antioxidant properties of	10
measured using a	10
nmr in drug	10
described the synthesis	10
of the dna	10
lung cancer cells	10
to achieve the	10
of chemical constituents	10
to create a	10
center of mass	10
small amount of	10
of the biological	10
of herbal medicine	10
are the most	10
the cancer cells	10
first step of	10
estimated binding energy	9
rational design of	9
were performed by	9
is a highly	9
of the bioactive	9
biscao dispersion and	9
is capable of	9
allowed us to	9
of inflammatory mediators	9
and hydrophobic interactions	9
compound in the	9
the cell culture	9
from selaginella tamariscina	9
h after the	9
it was not	9
the substitution of	9
to our knowledge	9
also used to	9
in human neutrophils	9
function of the	9
shown in the	9
among its active	9
vivo and in	9
crucial for the	9
as much as	9
of the cells	9
have demonstrated that	9
is not a	9
was set at	9
on the target	9
can act as	9
to generate a	9
with the ligand	9
to those of	9
this suggests that	9
give the product	9
most of these	9
potential of the	9
as we have	9
did not affect	9
substitution on the	9
in the air	9
and antifungal activities	9
of tumor cells	9
blood mononuclear cells	9
cells in a	9
to ns of	9
a and a	9
as previously described	9
presented as the	9
and application of	9
by forming a	9
identification of the	9
used as an	9
in vitro by	9
as reported by	9
carried out to	9
in the analysis	9
to optimize the	9
the phenolic group	9
is needed to	9
virus in the	9
of the new	9
aqueous solution of	9
the culture supernatant	9
minimum inhibitory concentration	9
the desired p	9
and sb techniques	9
cathepsin l inhibitor	9
regions of the	9
that the antiviral	9
of this study	9
further development of	9
design of the	9
importance in the	9
site of cathepsin	9
the reference drug	9
with a ph	9
addition of water	9
reverse transcriptase inhibitory	9
strategies have been	9
have been extensively	9
potential to be	9
screening for the	9
colorless and transparent	9
in cell culture	9
with a large	9
the relationship between	9
the outcome of	9
screening and design	9
separated from the	9
of the primary	9
the carbonyl group	9
by the amine	9
is favorable for	9
the decrease in	9
based inhibitors of	9
cell entry of	9
with the catalytic	9
refers to the	9
with the control	9
novel class of	9
remains to be	9
isoxazolidine analogues of	9
of the rna	9
of the genome	9
of the free	9
of porphyrins and	9
vero cells were	9
the innate immune	9
pred and ipminer	9
using the mmt	9
in the past	9
of mizoribine on	9
was performed to	9
the efficiency of	9
vicik et al	9
the copper catalyst	9
the viral rna	9
also showed that	9
the fabrication of	9
hepg cell line	9
results indicate that	9
respiratory tract infections	9
at least two	9
the suppression of	9
the newly synthesized	9
all of the	9
to calculate the	9
with those of	9
the enzyme active	9
group in the	9
with different concentrations	9
for the determination	9
human embryonic kidney	9
the molecular mechanism	9
are presented in	9
the best of	9
cathepsin l activity	9
statistical significance was	9
the highest binding	9
and apoptosis in	9
that the compound	9
was added and	9
cartoon representation of	9
were evaluated for	9
the difference between	9
method based on	9
was investigated using	9
authors suggested that	9
subjected to a	9
the obtained results	9
root mean square	9
development of the	9
with residues e	9
the magnetic field	9
in the isoxazolidine	9
for multiplexed detection	9
none of the	9
dna cleavage and	9
that it is	9
that received epa	9
ns have been	9
recent studies have	9
were harvested and	9
oxidative stress in	9
performed in a	9
and cytotoxicity of	9
reported the synthesis	9
of the desired	9
compounds with a	9
p a with	9
is a key	9
and leads to	9
protons in the	9
with a wide	9
used to measure	9
that could be	9
assay was performed	9
found in a	9
of antiviral agents	9
efficacy of the	9
in vitro the	9
proteins that are	9
for the formation	9
were cultured in	9
antiviral activity was	9
performed using the	9
the catalytic residues	9
antifungal activity of	9
the prevention of	9
along with their	9
the replacement of	9
at the c	9
a comprehensive review	9
dependent dna polymerase	9
and then the	9
the elimination of	9
coxsackie virus b	9
ligand binding site	9
is often used	9
cell cycle arrest	9
compared with that	9
a small amount	9
to note that	9
the expression levels	9
the severe acute	9
route to phosphoramidates	9
novel series of	9
these kinds of	9
the desired products	9
curves correspond to	9
play a critical	9
higher than the	9
induced by a	9
be discussed in	9
observed that the	9
inflammatory effects of	9
of action and	9
and did not	9
to identify potential	9
was lower than	9
high throughput screening	9
were obtained by	9
used as controls	9
and purification of	9
combined with the	9
energy in the	9
to the c	9
in the interaction	9
good agreement with	9
the indole moiety	9
that do not	9
the knowledge of	9
which results in	9
as a measure	9
anticancer effects of	9
could not be	9
the resulting mixture	9
studies have demonstrated	9
drug screening and	9
selective inhibitors of	9
the ranges of	9
we investigated the	9
of dengue virus	9
ray crystal structure	9
activity of caspase	9
the proposed method	9
o my by	9
of the crude	9
of west nile	9
needs to be	9
study showed that	9
concentrations of the	9
of the known	9
assays were performed	9
determined to be	9
in a variety	9
and analysis of	9
cbd in the	9
length of the	9
according to their	9
over the past	9
of the benzimidazole	9
the h n	9
used to treat	9
it could be	9
known to be	9
be considered as	9
hibiscus sabdariffa l	9
was assessed by	9
a is a	9
case of tmprss	9
pharmacological studies have	9
soybean trypsin inhibitor	9
docked pose of	9
we have also	9
peaks between the	9
but not the	9
stirring for h	9
of the plant	9
combined use of	9
supernatants were harvested	9
of compounds in	9
agents for the	9
substituents at c	9
belonging to the	9
action of the	9
to solid ratio	9
of hepg cells	9
and after the	9
the most widely	9
there was a	9
activity in the	9
value of the	9
the target cell	9
dna aptamers against	9
not able to	9
r r h	9
impact on the	9
the usa strain	9
into the host	9
and rna viruses	9
the absorbance of	9
a lot of	9
cd t cell	9
were observed in	9
to interfere with	9
the target and	9
the residue was	9
reduction in the	9
yields in the	9
protective effects of	9
in the final	9
of lb and	9
infection in vitro	9
and their applications	9
of chinese herbal	9
composed of a	9
has shown that	9
defined as the	9
a crucial role	9
amino acids in	9
is a novel	9
acid residues in	9
inhibition of hiv	9
course of the	9
of the docked	9
washed twice with	9
of the caspase	9
not affect the	9
of compounds of	9
of the benzoxazine	9
in relation to	9
hepg cells were	9
the virus into	9
in the screening	9
a basis for	9
results suggested that	9
cell death by	9
and in a	9
of the potential	9
many of the	9
the crystal structures	9
of ligands with	9
arctium lappa l	9
residues of the	9
the diversity of	9
and antifungal activity	9
in hepatocellular carcinoma	9
residues in the	9
therapeutic effects of	9
in the g	9
inhibitors of influenza	9
which was used	9
products were purified	9
the tested compounds	9
to the discovery	9
in the ranges	9
consequence of the	9
corresponds to the	9
the cost of	9
and the results	9
gene expression and	9
interaction of the	9
the host cells	9
concentration required to	9
in a single	9
activity against gram	9
the construction of	9
spectrum of ac	9
apoptotic cell death	9
ph of the	9
binding sites on	9
ac interacted with	9
cells were cultured	9
in the table	9
have been shown	9
was associated with	9
binding residue d	9
the sars coronavirus	9
the authors reported	9
purification of the	9
in hek cells	9
discovery of a	9
the bioactivity of	9
with more than	9
and for the	9
strand of dna	9
collected from the	9
in a large	9
commercial production of	9
coli topoisomerase iii	9
of the hcv	9
with substituents at	9
were dissolved in	9
have been selected	8
conformation of the	8
such as il	8
plays an important	8
new derivatives of	8
cancer cells via	8
against staphylococcus aureus	8
the mixed r	8
evaluated for their	8
antifungal activities of	8
a range of	8
prepared by a	8
and breast cancer	8
synthesized in the	8
the properties of	8
on the development	8
table and figure	8
after the first	8
of the eos	8
of a tcm	8
our understanding of	8
proteins such as	8
with severe acute	8
water and ml	8
with isolated yields	8
production of inflammatory	8
were calculated by	8
the surfaces of	8
biological activities of	8
treatment of the	8
drug delivery systems	8
on a stringent	8
the homology model	8
protease from t	8
of a base	8
with compound a	8
zone of mm	8
as an anti	8
identification and characterization	8
known inhibitors of	8
ccl in the	8
crucial role in	8
cells were infected	8
referred to as	8
of inflammatory cytokines	8
and validation of	8
of p and	8
on the template	8
of the aptamer	8
was calculated by	8
human formyl peptide	8
antiviral effects of	8
systemic lupus erythematosus	8
better understanding of	8
of oxidative stress	8
against tc and	8
have to be	8
to afford compound	8
of p mapk	8
of hydrogen bond	8
better than the	8
been demonstrated to	8
evaluation of novel	8
a function of	8
be valuable to	8
a suspension of	8
of the natural	8
pose with tmprss	8
diseases caused by	8
may contribute to	8
wormsk studies on	8
replication of the	8
necessary for the	8
specific inhibition of	8
to avoid the	8
resulted in an	8
suggests that the	8
of the above	8
have great potential	8
composition of the	8
in the leaves	8
p a inhibitor	8
with a specific	8
were pretreated with	8
derivatives were tested	8
red blood cells	8
kinds of compounds	8
a member of	8
pyrazolyl nucleosides a	8
escherichia coli atcc	8
surface of a	8
a target for	8
that the introduction	8
at p position	8
the first stage	8
were purified by	8
importance of the	8
bond with c	8
the diagnosis of	8
there are several	8
isolated from a	8
of pi k	8
cytochrome p a	8
of the cu	8
free radical scavenging	8
antiviral activities against	8
synthesis and anti	8
as a target	8
synthesis of the	8
the interactions of	8
diagnosis and treatment	8
of the four	8
are used to	8
a new class	8
were incubated at	8
chemokines and cytokines	8
a inhibitor predicted	8
the nmr spectra	8
was accompanied by	8
at the concentration	8
with the viral	8
targeted delivery of	8
the dried powder	8
of our knowledge	8
range of biological	8
are important for	8
was in the	8
evidenced by the	8
distance of the	8
of a phosphoric	8
viral replication and	8
synthesized using the	8
enzymes involved in	8
means that the	8
was calculated from	8
smegmatis topoisomerase i	8
in different cell	8
fe o mgo	8
in determining the	8
catalytic cys residue	8
cf following treatment	8
residue w forms	8
the need of	8
the beginning of	8
figure and table	8
and antiviral activities	8
broad range of	8
ring and the	8
further studies on	8
parts of cimicifuga	8
by decreasing the	8