quadgram

This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

quadgram	frequency
in the presence of	166
on the other hand	89
in the case of	85
for the treatment of	82
severe acute respiratory syndrome	71
in vitro and in	63
vitro and in vivo	54
no conflict of interest	53
in the eo of	53
the authors declare no	53
authors declare no conflict	53
declare no conflict of	52
as shown in figure	52
is one of the	50
for the development of	46
for peer review of	45
as well as the	45
x for peer review	45
for the synthesis of	45
in the range of	44
in the treatment of	42
chromatography to give compound	40
and then purified by	40
the presence of a	39
the terms and conditions	38
under the terms and	38
the creative commons attribution	38
to the general procedure	38
of the creative commons	38
and conditions of the	38
according to the general	38
conditions of the creative	38
terms and conditions of	38
by reverse phase flash	36
reverse phase flash chromatography	36
on the surface of	36
one of the most	35
purified by reverse phase	35
phase flash chromatography to	34
this article is an	34
distributed under the terms	34
tmprss and cathepsin l	34
access article distributed under	34
then purified by reverse	34
is an open access	34
open access article distributed	34
article distributed under the	34
flash chromatography to give	34
article is an open	34
the general procedure a	34
an open access article	34
porphyrins and their analogues	33
acute respiratory syndrome coronavirus	33
to the formation of	32
eo of wild hemp	31
the structure of the	31
the eo of wild	30
the surface of the	30
cathepsin l and b	30
in the development of	30
a wide range of	29
the eo of the	29
a large number of	28
the presence of the	28
can be used to	28
the antiviral activity of	28
the formation of the	28
are shown in figure	28
herpes simplex virus type	28
proposed mechanism for the	28
of the p a	27
the crystal structure of	27
human immunodeficiency virus type	27
was found to be	27
was treated with n	27
the active site of	26
inhibitors of cathepsin l	26
an important role in	26
this class of inhibitors	26
were found to be	25
purified by column chromatography	25
studies have shown that	24
was added to the	24
in the second step	24
in the first step	24
of human cathepsin l	24
in the formation of	24
with ic values of	23
in the field of	23
of tmprss and cathepsin	22
inhibitors of tmprss and	22
compound was treated with	22
the results indicated that	22
the best docked pose	21
forms hydrophobic contacts with	21
form hydrogen bonds or	21
residues that form hydrogen	21
that form hydrogen bonds	21
as shown in scheme	21
on the basis of	21
as shown in table	21
at the same time	21
of severe acute respiratory	20
the scope of the	20
hepg cells and mcf	20
and biological evaluation of	20
type hydrogen bond with	20
the results showed that	20
in the present study	20
in the absence of	20
hydrophobic contacts with residues	20
the activation of the	19
of human immunodeficiency virus	19
for the design of	19
was used as a	18
selectivity over cathepsin b	18
at room temperature for	18
in the active site	18
at a concentration of	18
when compared with the	18
synthesis and biological evaluation	18
has been reported to	18
as well as in	17
to the development of	17
shown in figure a	17
crystal structure of the	17
in a mouse model	17
strain scsio xws f	17
the crude product was	17
the presence of an	17
it was shown that	17
for the detection of	17
a binding energy of	17
was purified by column	17
were recorded on a	17
in addition to the	17
in the form of	17
autophagic cell death in	16
both in vitro and	16
food and drug administration	16
an ic value of	16
the reaction mixture was	16
lb and sb methods	16
the effect of the	16
in vitro selection of	16
interaction of ac with	16
epidermal growth factor receptor	16
against hepg cells and	16
has a binding energy	16
the concentration of the	16
of the breeding lines	15
the analysis of the	15
as a result of	15
alanine and then purified	15
one of the main	15
for the extraction of	15
the formation of a	15
can be used for	15
of this class of	15
it is important to	15
of ac with naoh	15
when compared to the	15
it is noteworthy that	15
the results revealed that	15
the production of il	15
the use of a	15
activity against hepg cells	14
in the pathogenesis of	14
with an ic value	14
silica gel column chromatography	14
phytochemical inhibitors of tmprss	14
were used as the	14
chronic obstructive pulmonary disease	14
below the detection limit	14
is due to the	14
product was purified by	14
the intensity of the	14
play an important role	14
the distance between the	14
a critical role in	14
have been found to	14
the formyl peptide receptor	14
has been shown to	14
at the end of	14
l and b in	13
the interaction of ac	13
spectra were recorded on	13
the porphyrins and their	13
inhibitor of cathepsin l	13
reported in the literature	13
vascular endothelial growth factor	13
type hydrogen bonds with	13
a mouse model of	13
for the first time	13
a wide variety of	13
as a consequence of	13
of traditional chinese medicine	13
the end of the	13
at position of the	13
small cell lung cancer	13
in the s subsite	13
that the presence of	13
crude product was purified	13
in ewat of hfd	13
a key role in	13
can also be used	13
compared to the standard	13
led to the formation	13
similar to that of	13
was expressed as the	13
the results of the	13
is involved in the	13
has been used for	13
as a positive control	13
of cathepsin l and	13
a colorless amorphous solid	13
of cathepsin l with	13
has been widely used	13
is shown in figure	13
by the presence of	12
by silica gel column	12
on the constituents of	12
simultaneous detection of multiple	12
is formed in the	12
o type hydrogen bond	12
both cathepsin l and	12
following treatment with undiluted	12
the rpi data set	12
tc and cf remained	12
gold bean trypsin inhibitor	12
used to determine the	12
for the analysis of	12
the constituents of cimicifuga	12
inhibitor predicted by vnnadmet	12
de novo drug design	12
the antibacterial activity of	12
cancer cells in vitro	12
after oral administration of	12
purified by silica gel	12
the early stages of	12
developed a series of	12
in the regulation of	12
the binding of the	12
nmr spectra were recorded	12
cells were treated with	12
of herpes simplex virus	12
it is worth noting	12
are summarized in table	12
the simultaneous detection of	12
in the best docked	12
the synthesis of p	12
for the use of	12
isolation and characterization of	12
in the search for	12
used in the treatment	12
of hepatitis c virus	12
in the spectra of	12
fold selectivity over cathepsin	12
the case of the	12
and cf remained viable	12
design and synthesis of	12
the chemical structure of	12
mediated synthesis of phosphoramidates	12
studies on the constituents	12
at the s pocket	12
that most of the	11
of a series of	11
was developed using the	11
for binding to the	11
been found to be	11
it was found that	11
shows the cathepsin l	11
to uv light for	11
should be noted that	11
was carried out on	11
ns of the md	11
acute respiratory distress syndrome	11
ic values in the	11
of the indole ring	11
to give the desired	11
constituents of cimicifuga species	11
with respect to the	11
important role in the	11
in the s pocket	11
the substrate binding residue	11
exposed to uv light	11
been reported to be	11
ph of biscao water	11
scsio xws f was	11
compounds were evaluated against	11
of the registered cultivars	11
have been reported to	11
it is possible to	11
added to each well	11
are involved in the	11
involves the formation of	11
t forms hydrophobic contacts	11
in the intensity of	11
natural deep eutectic solvents	11
h at room temperature	11
synthesis and evaluation of	11
be attributed to the	11
the introduction of a	11
developed using the coreldraw	11
eo of the breeding	11
results showed that the	11
l residues that form	11
to bind to the	11
is worth noting that	11
image was developed using	11
best docked pose with	11
it should be noted	11
has also been used	11
the use of metal	11
cathepsin l residues that	11
mechanism of action of	11
proliferative activity against hepg	11
using the coreldraw software	11
scope of the synthesis	11
role of autophagy in	11
the cathepsin l residues	11
this image was developed	11
the rest of the	11
and characterization of a	11
cells with ic values	11
and dpph radical scavenging	11
stacking interactions with c	11
in the search of	11
have been developed to	11
of the synthesis was	11
has been found to	11
herbal medicine and tcm	11
is responsible for the	11
uv light for min	10
of the eo of	10
with permission from the	10
a molecular mass of	10
as well as for	10
the tmprss residues that	10
this class of compounds	10
inhibitor predicted by swissadme	10
center of mass of	10
a new series of	10
the s pocket of	10
of reactive oxygen species	10
in comparison to the	10
the formation of an	10
of the reaction was	10
in the production of	10
in view of the	10
for the identification of	10
in the nanomolar range	10
it was observed that	10
cfu ml for tc	10
been reported to have	10
about ppm for c	10
for the production of	10
of cancer cells and	10
remained viable following treatment	10
have been reported in	10
the fact that the	10
the aerial parts of	10
stacking interactions with t	10
induced autophagic cell death	10
against herpes simplex virus	10
of these compounds were	10
human umbilical vein endothelial	10
with the cell membrane	10
the development of novel	10
recorded on a bruker	10
was based on the	10
of the ple band	10
as in the case	10
synthesis of compounds a	10
the nature of the	10
as well as their	10
in breast cancer cells	10
viable following treatment with	10
signal amplification by reversible	10
the stability of the	10
was used as the	10
the d structure of	10
are listed in table	10
amine to give the	10
cf remained viable following	10
bioinformatics and molecular modeling	10
to the synthesis of	10
results are presented as	10
c forms hydrophobic contacts	10
have been used as	10
frap and dpph radical	10
the development of a	10
tmprss residues that form	10
shows the tmprss residues	10
with an ic of	10
described the synthesis of	10
the wealth of india	10
the first step of	10
be used as a	10
at the active site	10
with the exception of	10
the synthesis was explored	10
of the target protein	10
on a bruker avance	10
of the md simulation	10
the antioxidant activity of	10
amplification by reversible exchange	10
the cfu ml for	10
the usa hemp strain	10
and granules of r	10
from ns to ns	10
ml for tc and	10
been used as a	10
exposure to uv light	10
been used for the	10
the carbon atoms of	10
the center of mass	10
the human immunodeficiency virus	10
carbon atoms of the	10
for tc and cf	10
with the aid of	10
herbs and tcm formulas	10
the mechanism of action	10
hydrogen bonds with residues	10
in the crystal structure	10
the isomeric pyrazolyl nucleosides	10
umbilical vein endothelial cells	10
of the test compounds	10
in the synthesis of	10
scn a sodium voltage	10
the ability of the	10
the ph of the	9
as the reference compounds	9
curves correspond to the	9
a consequence of the	9
the plates were incubated	9
the rgdechi d peptide	9
will be discussed in	9
these results suggest that	9
with ic values in	9
patients with severe covid	9
for the formation of	9
in the process of	9
are shown in table	9
in vivo and in	9
in the ranges of	9
showed the highest binding	9
for multiplexed detection of	9
in the work of	9
binding energy in the	9
the solvent was removed	9
the mechanism of the	9
the binding affinity of	9
of cimicifuga simplex wormsk	9
the antiviral efficacy of	9
of the virus into	9
of the most promising	9
other members of the	9
active cathepsin l and	9
of the most common	9
of the nlrp inflammasome	9
the development of new	9
was observed in the	9
in complex with the	9
can be found in	9
the antioxidant capacity of	9
to the active site	9
in the analysis of	9
mechanism of the reaction	9
is similar to that	9
the fusion of the	9
drug screening and design	9
coli dna topoisomerase i	9
of the amino acid	9
nuclear magnetic resonance spectroscopy	9
the amino acid residues	9
active site of the	9
play a critical role	9
selectivity towards cathepsin l	9
the role of autophagy	9
the antiviral effect of	9
in the fight against	9
the expression levels of	9
of the s subsite	9
the structures of the	9
as a measure of	9
and the ph of	9
amino acid residues in	9
of lb and sb	9
of the active site	9
of dna and rna	9
for the determination of	9
in a variety of	9
to ns of the	9
autophagic cell death of	9
been reported in the	9
results indicated that the	9
the binding site of	9
are presented as the	9
to the best of	9
to a solution of	9
efficacy and safety of	9
the binding pocket of	9
no effect on the	9
the severe acute respiratory	9
substrate binding residue d	9
ns to ns of	9
site of cathepsin l	9
energy in the best	9
yields in the range	9
lb and sb techniques	9
were the most active	9
dna and rna viruses	9
peripheral blood mononuclear cells	9
used as the reference	9
to give the product	9
crude products were purified	9
of porphyrins and their	9
a small amount of	9
without the need for	9
binding to the target	8
been widely used in	8
cell entry of sars	8
play a role in	8
spectra of the complexes	8
concentrated under reduced pressure	8
due to the presence	8
cathepsin l and cathepsin	8
reported the synthesis of	8
is directly related to	8
concentration in the eo	8
against a panel of	8
oxidation of a phosphoric	8
h n and h	8
of tc and cf	8
both dna and rna	8
was measured using a	8
of west nile virus	8
nmr spectra of the	8
compared with that of	8
phytochemicals whose binding energy	8
presented as the mean	8
best of our knowledge	8
used in this study	8
that the introduction of	8
of a phosphoric ester	8
human breast cancer cells	8
used to evaluate the	8
in the last years	8
water and co in	8
active site of cathepsin	8
the detection limit of	8
the binding energy of	8
be used for the	8
these results suggested that	8
effect of mizoribine on	8
structural basis for the	8
with severe acute respiratory	8
the combined use of	8
a broad range of	8
c inhibitor predicted by	8
contacts with residues e	8
was added to each	8
we found that the	8
the prepared compounds were	8
the world health organization	8
o type hydrogen bonds	8
the molecular mechanisms of	8
a crucial role in	8
in traditional chinese medicine	8
hydrogen bond with residue	8
nucleophilic attack from the	8
the residue w forms	8
structure of the sars	8
of a tcm formula	8
inhibition zone of mm	8
are responsible for the	8
in biscao water and	8
following are available online	8
a significant increase in	8
plays an important role	8
the course of the	8
the main chain of	8
a series of compounds	8
tc and cf following	8
antiviral activity of mizoribine	8
of the most potent	8
bean trypsin inhibitor is	8
calculated for c h	8
whose binding energy in	8
the virus into the	8
wide range of biological	8
p c inhibitor predicted	8
concentration required to reduce	8
cbd in the eo	8
in a recent study	8
to note that the	8
of strain scsio xws	8
identification and characterization of	8
docked pose with tmprss	8
the mechanisms of action	8
it has been reported	8
had no effect on	8
co in the air	8
were purified by column	8
tmprss in complex with	8
discovery and development of	8
have been used in	8
has also been reported	8
amine in the presence	8
on the development of	8
correlation peaks between the	8
is based on the	8
mg d s g	8
products were purified by	8
the activity of caspase	8
the evaluation of the	8
of this compound in	8
simplex wormsk studies on	8
with about ppm for	8
these kinds of compounds	8
the best of our	8
n and h n	8
and anhydrous k co	8
biscao water and co	8
and cf following treatment	8
and b in different	8
cells were infected with	8
in vitro inhibition of	8
statistical significance was analyzed	8
of type ia topoisomerases	8
reproduced with permission from	8
a novel class of	8
the results are presented	8
among its active molecules	8
to the standard drug	8
cytochrome p a inhibitor	8
a chemical shift of	8
the indication to use	8
eo of the registered	8
the concentration of this	8
selective inhibitor of cathepsin	8
were below the detection	8
biscao dispersion and colloidal	8
c in a humidified	8
dispersion and colloidal dispersion	8
in the free ligand	8
the binding mode of	8
to the presence of	8
hydrogen bond with c	8
using a mixture of	8
the relative configurations of	8
fusion with the cell	8
and co in the	8
at the p position	8
middle east respiratory syndrome	8
of cancer cell lines	8
the most potent compounds	8
a inhibitor predicted by	8
over the course of	8
d structure of the	8
of cathepsin l in	8
the treatment of covid	8
docking and molecular dynamics	8
the tc and cf	8
relative configurations of isoxazolidines	8
dpph radical scavenging values	8
wormsk studies on the	8
cytochrome p c inhibitor	8
pi k akt mtor	8
of the virus and	8
the crystal structures of	8
the protein data bank	8
a phosphoric ester group	8
the enzyme active site	8
the following are available	8
against tc and cf	8
the scope of this	8
from the authors of	8
cartoon representation of the	8
to of the eo	8
for h at room	8
parts of cimicifuga simplex	8
p a inhibitor predicted	8
has been reported that	8
higher than that of	8
small molecule inhibitors of	8
cimicifuga simplex wormsk studies	8
range of biological activities	8
of indian medicinal plants	8
binding energy of the	8
at the p site	8
is essential for the	8
stacking interaction with c	8
permission from the authors	8
values in the range	8
presence of h o	7
a new class of	7
as indicated in the	7
that the addition of	7
lower than that of	7
extraction of otn from	7
cov cl pro complexed	7
ml of tc and	7
of the copper catalyst	7
in agreement with the	7
to investigate the effect	7
based analytical devices for	7
the eo of cv	7
shown in figure c	7
ca ions in biscao	7
to that described for	7
from the leaves of	7
between ca ions in	7
of three independent experiments	7
has been used as	7
to the lungs of	7
bu n br as	7
at the early stages	7
binding sites on the	7
results are expressed as	7
to be involved in	7
in the identification of	7
previous studies have shown	7
on the structure of	7
compared to the control	7
the activation of caspase	7
the concentration of il	7
have been shown to	7
the beginning of the	7
reported to have anti	7
creative commons attribution license	7
supernatants were harvested and	7
the importance of the	7
the cell viability was	7
a number of studies	7
dna and rna topoisomerase	7
cfu ml of tc	7
lower than the original	7
to afford the desired	7
in the low micromolar	7
in accordance with the	7
were obtained as tfa	7
with an elimination of	7
the therapeutic potential of	7
this compound in the	7
a novel series of	7
of the ligand in	7
breast cancer cell line	7
water and ml solvent	7
apoptosis and autophagy in	7
at the beginning of	7
with inhibition zones of	7
widely used in the	7
molecular similarity and docking	7
was used to compare	7
were then subjected to	7
did not affect the	7
with the aim of	7
one of the major	7
in response to the	7
in vitro evaluation of	7
activity of some new	7
and respiratory syncytial virus	7
cathepsin l in complex	7
the virus and the	7
cl pro complexed with	7
scope of the reaction	7
the ph of each	7
the authors reported that	7
to afford the corresponding	7
are expressed as means	7
in comparison with the	7
dna aptamers have been	7
a member of the	7
of the virion to	7
activity was expressed as	7
commercial production of cbd	7
of ac interacted with	7
and its application to	7
the p a and	7
the tmprss model structure	7
the molecular mechanism of	7
to the discovery of	7
a low detection limit	7
the virion to the	7
could be attributed to	7
also been used to	7
the aqueous solution of	7
is in agreement with	7
with a wide range	7
to be used in	7
supplementary figure s a	7
of the host cell	7
synthesis and biological activity	7
a selective inhibitor of	7
in this study were	7
a result of the	7
interaction between ca ions	7
additional water and ml	7
in good agreement with	7
the presence of h	7
in the activation of	7
the synthesis of phosphoramidates	7
by chen et al	7
of potential molecular targets	7
of the ir bands	7
used for the treatment	7
natural product inhibitors of	7
activity of essential oils	7
research has shown that	7
figures s and s	7
d r grand challenge	7
spectra of compounds a	7
the interaction of the	7
of the prepared compounds	7
to the host cell	7
to be used as	7
of the isomeric pyrazolyl	7
stage of attachment of	7
antibacterial and antifungal activity	7
with high affinity and	7
a better understanding of	7
nucleophilic attack on the	7
ions in biscao water	7
selectivity for cathepsin l	7
turned out to be	7
of attachment of the	7
of the structure of	7
aminophenol and sodium acetate	7
l in complex with	7
covalent bond with the	7
chemical structure of the	7
of the interaction of	7
the active sites of	7
of the wild hemp	7
as a function of	7
room temperature for min	7
the raman spectrum of	7
it is well known	7
the inhibitory effect of	7
surface of the protein	7
were used as controls	7
cells were incubated with	7
in patients with severe	7
is well known that	7
cells were seeded in	7
release of cytochrome c	7
cells were cultured in	7
epa and ht co	7
have also been reported	7
on the use of	7
the noe spectra of	7
was found to inhibit	7
as compared to the	7
of essential oils from	7
antioxidant capacity of umifenovir	7
is it possible that	7
could be used as	7
biscao water was sprayed	7
sodium acetate and formic	7
be due to the	7
have led to the	7
diagnosis and treatment of	7
phytochemical inhibitors of cathepsin	7
in the context of	7
obtained as tfa salts	7
model structure of tmprss	7
and central nervous system	7
the major components of	7
of herbal medicine and	7
of the peptide to	7
a comparison of the	7
the position of the	7
the synthesis of compounds	7
used as a control	7
innate and adaptive immunity	7
the eos of the	7
the use of the	7
of influenza a virus	7
to a variety of	7
the central nervous system	7
and mrna levels of	7
the area of the	7
and the reaction mixture	7
for the recognition of	7
crystal structure of human	7
attachment of the virion	7
the antioxidant effect of	7
stage of zikv infection	7
the low micromolar range	7
the side chain of	7
the main protease of	7
by exposure to uv	7
the resulting mixture was	7
this led to the	7
of the immune system	7
and rna topoisomerase activities	7
expressed as the mean	7
oxygen atom of the	7
presence of a base	7
the rna topoisomerase activity	7
vivo and in vitro	7
acetate and formic acid	7
the case of tmprss	7
for the simultaneous detection	7
data are expressed as	7
is related to the	7
drug discovery and development	7
have been used to	7
and fractions of interest	7
carried out on a	6
into the host cell	6
selectivity toward cathepsin l	6
as potential inhibitors of	6
with cathepsin l and	6
the treatment of asthma	6
in complex with c	6
apoptosis of cancer cells	6
was obtained from the	6
as an anticancer drug	6
isolated from selaginella tamariscina	6
of a novel coronavirus	6
attacked by the amine	6
authors suggested that this	6
its weaker binding affinity	6
and antifungal activities of	6
same trend but with	6
and developed an affinity	6
of the pyrazole compounds	6
use of metal nanoparticles	6
and fusion with the	6
and biological activity of	6
counts of tc and	6
an example of this	6
antioxidant effect of umifenovir	6
reagents that selectively labels	6
synthesis from organic azide	6
the photoactivatable benzoyl group	6
shown in green colour	6
in the screening of	6
activity of mizoribine against	6
the biotinylated probe was	6
of these prepared compounds	6
is the area of	6
those with substituents at	6
was identified as a	6
in the discovery of	6
at different stages of	6
models of potential molecular	6
a desthiobiotinylated analog also	6
was measured over the	6
the molecular formula of	6
to the use of	6
a strong labeling of	6
of the influenza virus	6
creative commons attribution the	6
that was lower than	6
to incubation with p	6
that are essential for	6
and the lowest in	6
channel type scn a	6
residue was purified by	6
residue w forms a	6
and irreversible cathepsin inhibitor	6
from the roots of	6
when the enzyme was	6
the ic value of	6
the absorbance of the	6
irreversibly inactivates the enzyme	6
of the usa hemp	6
in order to obtain	6
was sprayed onto the	6
investigate the effect of	6
supernatant was measured using	6
by the addition of	6
on silica gel columns	6
in the culture supernatant	6
at the enzyme pocket	6
a value that was	6
of amino acid residues	6
binding affinity to streptavidin	6
cytochrome c from mitochondria	6
reduced labeling due to	6
levels of zikv rna	6
intensity of the ple	6
expressed as the ec	6
was refluxed for h	6
docking simulations showed that	6
is associated with the	6
in hepg cell line	6
for the fabrication of	6
a solution of the	6
the enzyme via covalent	6
in the n gene	6
selection of dna aptamers	6
that selectively labels enzymes	6
as c h o	6
value that was lower	6
subjected to gel electrophoresis	6
the pyrazole compounds a	6
protease falcipain and cathepsin	6
directed competitive and irreversible	6
it is obvious that	6
of the severe acute	6
panel of cancer cell	6
by appel and einig	6
the absence of the	6
may be responsible for	6
of cbd in the	6
which is typical for	6
inactivates the enzyme via	6
the early stage of	6
on a stringent criteria	6
to its weaker binding	6
the specificity of the	6
synthesis and characterization of	6
the synthesis of a	6
are expressed as mean	6
this scaffold could be	6
be utilized for the	6
us food and drug	6
color coded and the	6
proton adjacent to n	6
combined lb and sb	6
best docked pose of	6
n atom of the	6
in one of the	6
coded and the photoactivatable	6
be related to the	6
and antiviral activity of	6
in the present work	6
resulting in the formation	6
solubility class predicted by	6
the percentage of apoptotic	6
compounds b and c	6
the biotinylated compound inhibited	6
of a variety of	6
may contribute to the	6
for affinity pull down	6
cancer cell line hs	6
of the aqueous solution	6
the active site tyrosine	6
total residues were in	6
by the amine to	6
in complex with t	6
ratio is equal to	6
the rapid development of	6
the increase of the	6
in drug discovery and	6
moiety is utilized for	6
the catalytic cys residue	6
h o as a	6
the usa strain eo	6
also be used to	6
of mm compared to	6
probe was incubated with	6
i and type ii	6
radioactive reagents that selectively	6
diameter of inhibition zone	6
we decided on a	6
liquid to solid ratio	6
culture supernatant was measured	6
of negatively supercoiled dna	6
have been proposed to	6
shown in figure b	6
of the selected compounds	6
the purified trypsin inhibitor	6
both tc and cf	6
could be utilized for	6
the total residues were	6
tumor necrosis factor alpha	6
and molecular docking studies	6
escherichia coli dna topoisomerase	6
in line with this	6
the genetic material of	6
the spikes on the	6
proliferation of cancer cells	6
as the number of	6
and exposed to streptavidin	6
ac interacted with naoh	6
and the photoactivatable benzoyl	6
have been used for	6
to a chemical shift	6
demonstrated the importance of	6
results in the formation	6
a wealth of information	6
for compounds of series	6
for the active site	6
the design of new	6
the reference compounds may	6
studies have reported that	6
the same trend but	6
using the mmt assay	6
is determined by the	6
the anomeric proton adjacent	6
coworkers described the synthesis	6
demonstrating that p competes	6
lb and sb strategies	6
that p competes for	6
can be classified as	6
inactivation of rna viruses	6
from s to s	6
evolution of ligands by	6
the eo of registered	6
been shown to be	6
appear to a chemical	6
with that of the	6
be responsible for the	6
scaffold could be utilized	6
on a series of	6
vitro selection of rna	6
enzyme via covalent modification	6
to probe cathepsin l	6
on the rpi data	6
ratio and additional water	6
biotinylated compound inhibited plasmodial	6
amino acids of the	6
involved in the regulation	6
strong labeling of the	6
inhibitory activities than emodin	6
colloidal dispersion were below	6
after the interaction with	6
the p a to	6
suggested that this scaffold	6
showed the presence of	6
ligand binding site residues	6
the target compounds a	6
induce autophagic cell death	6
binding energies of the	6
first developed biotinylated aziridine	6
and lanthanide containing dota	6
usa strain eo was	6
according to the manufacturer	6
ion exchange chromatography on	6
purification was effected by	6
inhibition zones of mm	6
of new derivatives of	6
were in the ranges	6
curve corresponds to the	6
s pocket of cathepsin	6
of compounds in which	6
treatment with compound a	6
were added to the	6
cardiotoxicity induced by aconitine	6
s is the area	6
the development of cell	6
in the design of	6
in drug discovery research	6
an increase in the	6
dna cleavage and relaxation	6
the introduction of the	6
of each of the	6
down and target identification	6
the presence of two	6
clearly demonstrating that p	6
potential natural product inhibitors	6
zone of mm compared	6
a panel of cancer	6
p competes for the	6
the crude products were	6
cells in vitro and	6
the presence of phosphine	6
inflammatory cytokines and chemokines	6
concentration of this compound	6
to the powerful deshielding	6
w forms a face	6
commons attribution the authors	6
recent advances in the	6
the role of the	6
due to its weaker	6
with substituents such as	6
was treated with e	6
the h nmr spectra	6
the process according to	6
purification of the products	6
the result of the	6
weaker binding affinity to	6
of the crystal structure	6
shift of about ppm	6
that the use of	6
chemical shift of about	6
of autophagic cell death	6
site of the enzyme	6
l and subjected to	6
in hydrogen bond formation	6
involved in parasite pathogenicity	6
naoh weight ratio is	6
labels enzymes involved in	6
via organic azide generation	6
might be due to	6
compound inhibited plasmodial protease	6
has been used to	6
type scn a sodium	6
but with reduced labeling	6
stands for template size	6
with reduced labeling due	6
crystal structure of sars	6
analog irreversibly inactivates the	6
all of these derivatives	6
selected for biological testing	6
plasmodial protease falcipain and	6
process according to mechanism	6
exhibited the same trend	6
inhibitor complex was observed	6
anomeric proton adjacent to	6
decided on a stringent	6
of type ia topoisomerase	6
to below the detection	6
ic values ranging from	6
bovine viral diarrhea virus	6
by wang et al	6
the comfa and comsia	6
that in the first	6
more potent than the	6
is coded in blue	6
compounds of series i	6
the rate constants were	6
affinity label to probe	6
incubated at room temperature	6
the highest concentration tested	6
found to be more	6
phosphoramidate synthesis from organic	6
synthesis of phosphoramidates from	6
synthesis and in vitro	6
structural models of potential	6
the determination of the	6
is the most common	6
mechanism for the synthesis	6
results suggest that the	6
a powerful tool for	6
an inhibition zone of	6
in gold bean trypsin	6
cathepsin l and subjected	6
at concentrations up to	6
of ligands by exponential	6
after h of incubation	6
in the united states	6
systematic evolution of ligands	6
an affinity label to	6
of compound a on	6
peer review of figure	6
incubated for h at	6
the oxygen atom of	6
step consist in the	6
in the usa strain	6
compound concentration required to	6
in a co incubator	6
the virus life cycle	6
trend but with reduced	6
room temperature for h	6
human cancer cell lines	6
isomer of the biotinylated	6
on chemical constituents of	6
class predicted by swissadme	6
zones of mm and	6
in a similar fashion	6
the effects of the	6
performed in order to	6
as a radical initiator	6
also exhibited the same	6
of drying biscao water	6
mm compared to the	6
a mechanism of the	6
with the formation of	6
the identified phytochemical inhibitors	6
and subjected to gel	6
line with this observation	6
to uv light of	6
mixture was refluxed for	6
the phenolic hydroxyl group	6
received epa or ht	6
been approved by the	6
and coworkers described the	6
a stringent criteria of	6
conjugated biotin moiety is	6
affinity pull down and	6
plays a critical role	6
in drug design and	6
from the seeds of	6
in type ia topoisomerases	6
of the biotinylated probe	6
of gold nanoparticles in	6
gated channel type scn	6
air as a radical	6
after treatment with a	6
with isolated yields of	6
original ph of biscao	6
the formation of p	6
dispersion were below the	6
in the soret region	6
used to screen the	6
ligands by exponential enrichment	6
of mass of the	6
and colloidal dispersion were	6
low counts of tc	6
to compare the sample	6
is shown in table	6
attack from the amine	6
the labeling was diminished	6
biscao water on the	6
inhibit the activity of	6
from three independent experiments	6
in the crystal structures	6
competes for the active	6
as well as to	6
of the polyphenolic compounds	6
the aziridine analog irreversibly	6
studies are needed to	6
relaxation of negatively supercoiled	6
then purified by silica	6
eo of the usa	6
antiviral activity was expressed	6
from the aerial parts	6
activity of silver nanoparticles	6
in supplementary table s	6
for comfa and comsia	6
type i and type	6
entry into host cells	6
used for the synthesis	6
of the total residues	6
the interaction with naoh	6
of aryl vinylsulfonate ester	6
was the most potent	6
it is difficult to	6
the significance of the	6
human formyl peptide receptor	6
the discovery of a	6
during ns to ns	6
hydrolytic or enzymatic cleavage	6
probe cathepsin l activity	6
from organic azide and	6
although p has a	6
the induction of autophagy	6
a white powder coating	6
and selective inhibitors of	6
the same trend as	6
detection of multiple analytes	6
was incubated with cathepsin	6
utilized for affinity pull	6
products in the range	6
used to enhance the	6
compare the sample groups	6
it is not known	6
induced by aconitine alkaloids	6
using air as a	6
and after the interaction	6
effect of compound a	6
pull down and target	6
reduced to below the	6
one of the first	6
development of new drugs	6
and breast cancer cell	6
that this scaffold could	6
also been reported in	6
results indicate that the	6
concentration of the compound	6
competitive and irreversible cathepsin	6
these prepared compounds were	6
of these derivatives were	6
of biscao water was	6
according to published procedures	6
ph of each wet	6
with substituents at c	6
the spectra of the	6
predicted by swissadme using	6
the most active compound	6
gel column chromatography to	6
developed an affinity label	6
the formyl peptide receptors	6
parameters evaluated in ewat	6
derivatives were tested against	6
a second type of	6
of the main chain	6
incubated with cathepsin l	6
the area of depression	6
for the selection of	6
the enzyme was treated	6
be used in the	6
different from that of	6
in close proximity to	6
labeling of the enzyme	6
human tumor cell lines	6
is colorless and transparent	6
beyond the scope of	6
at different time points	6
potential to be used	6
endothelial growth factor receptor	6
percentage of apoptotic cells	6
the applicability of the	6
in situ azide generation	6
than the original ph	6
selectively labels enzymes involved	6
is utilized for affinity	6
measured over the course	6
cell line hs t	6
the development of the	6
patchouli alcohol and oseltamivir	6
the need for an	6
column chromatography to give	6
structure and function of	6
on the type of	6
was used for the	6
of cytochrome c from	6
for template size of	6
the ligand binding site	6
compound and its derivatives	6
for cathepsin l over	6
based on the structure	6
effected by column chromatography	6
cleavage and relaxation activity	6
falcipain and cathepsin l	6
which reacts further with	6
enzymes involved in parasite	6
the original ph of	6
dicarboxylate and demonstrated its	6
enzyme was treated with	6
subsequently exposed to uv	6
peaks between the aromatic	6
the substitution of the	6
identified phytochemical inhibitors of	6
inflammatory diseases such as	6
reduction of the nitro	6
utilized for the development	6
that acts as a	6
the conjugated biotin moiety	6
due to the powerful	6
prior to incubation with	6
influenced by increasing the	6
was effected by column	6
the inhibition of the	6
and coworkers prepared a	6
were in the range	6
as potent inhibitors of	6
plays a key role	6
inhibited plasmodial protease falcipain	6
of the porphyrins and	6
biotin moiety is utilized	6
cf following treatment with	6
afford the desired products	6
the culture supernatant was	6
used to compare the	6
was further confirmed by	6
that are involved in	6
labeling due to its	6
the quality of the	6
weight ratio is equal	6
contacts with residues g	6
the mixture was stirred	6
analog also exhibited the	6
that can be used	6
immediately after spraying was	6
label to probe cathepsin	6
increased in ewat of	6
was lower than the	6
were used as a	6
with an inhibition zone	6
the efficacy of a	6
the ability to inhibit	6
was added to a	6
on the viral envelope	6
desthiobiotinylated analog also exhibited	6
the difference between the	6
involved in the pathogenesis	6
of autophagy in the	6
compounds and fractions of	6
in patients with covid	6
via in situ azide	6
it was suggested that	6
the table gives the	6
biotinylated probe was incubated	6
aziridine analog irreversibly inactivates	6
and demonstrated its antiplasmodial	5
dipolar cycloaddition of nucleobase	5
domains d and d	5
compounds were identified as	5
worth noting that the	5
s subsite of the	5
the vast majority of	5
this indicates that the	5
the application of the	5
was performed based on	5
may be attributed to	5
variation in the intensity	5
series of nitrile compounds	5
in the structure of	5
it is necessary to	5
on the activation of	5
atom at position of	5
inhibited the expression of	5
has been proven to	5
a higher concentration of	5
is determined by two	5
used as the standard	5
the anticancer activities of	5
of patchouli alcohol and	5
l and cathepsin b	5
a decrease in the	5
between the p a	5
which is consistent with	5
in the eos of	5
preferred at this position	5
the p a with	5
activity against h n	5
released from the contaminated	5
showed ic values of	5
purification and characterization of	5
of distinct phylogenetic origins	5
that the combination of	5
the time of addition	5
enhance the sensitivity of	5
a set of technical	5
for a total of	5
of bacterial topoisomerase i	5
exerted the maximum potency	5
spans the active site	5
it is also important	5
the highest binding affinity	5
pro complexed with inhibitor	5
colour while the carbon	5
the data presented in	5
residues interacting with the	5
a new approach for	5
production of inflammatory mediators	5
bactericidal activities of biscao	5
present in c forms	5
it is worth mentioning	5
letter residue code along	5
compared to the reference	5
used to increase the	5
solvent was removed in	5
with fetal bovine serum	5
yields ranging from to	5
has been approved by	5
on the indole ring	5
the structural basis for	5
from different natural sources	5
the detection of multiple	5
of the phenolic group	5
that described for a	5
was established as c	5
from a number of	5
product is formed in	5
the interaction with the	5
the inactivation exhibited the	5
in the registered cultivars	5
h and c nmr	5
the ligand are shown	5
transcription and replication of	5
the slow part of	5
supplementary figure s b	5
a diverse set of	5
ns have been used	5
the following trend for	5
of action of the	5
of indian raw materials	5
the bidentate ligand trough	5
the test compounds was	5
the active site and	5
dna and rna molecules	5
atoms via hydrogen bonds	5
to be effective against	5
hydrophobic substituents were preferred	5
figure a and b	5
the indole ring and	5
of chronic obstructive pulmonary	5
lysosomes and whole cells	5
group in was protected	5
of otn from human	5
and cd t cell	5
phosphoryl amino acid esters	5
by epa or ht	5
on a silica gel	5
min at room temperature	5
compound a for h	5
the addition of the	5
be discussed in the	5
analysis of the enzyme	5
is worth mentioning that	5
of the binding pocket	5
after ns of the	5
in a separate study	5
have reported on the	5
chemical shifts of the	5
this is followed by	5
ligand atoms via hydrogen	5
in order to achieve	5
of the genetic material	5
from plus lab corp	5
in a rat model	5
the third intracellular loop	5
for the identification and	5
bond formation with the	5
of a panel of	5
formed in the second	5
gene expression of the	5
and the remaining treatments	5
more potent activity than	5
the effectiveness of the	5
only a marginal selectivity	5
the interaction between the	5
listed in supplementary table	5
a transient covalent bond	5
been found to have	5
various cancer cell lines	5
figure c shows the	5
a promising alternative to	5
antibacterial activity against gram	5
delivery of rnai molecules	5
were washed twice with	5
direct precipitation with acetonitrile	5
demonstrated its antiplasmodial activity	5
a change in the	5
at the plasma membrane	5
the production of inflammatory	5
amino acids in the	5
the molecular mechanisms and	5
was considered as and	5
a silica gel column	5
which are related to	5
which consists of two	5
methanolic ammonia provided the	5
electrotransferred to a membrane	5
radical scavenging and frap	5
position in the protein	5
as indicated in figure	5
subsite of the enzyme	5
basis for the recognition	5
and the results were	5
top inhibitors of tmprss	5
has been proposed to	5
compounds were screened for	5
have been isolated from	5
glycan cryptic sugar moieties	5
detection limit of the	5
aqueous extracts of roselle	5
human colon cancer cells	5
the corresponding single letter	5
of harringtonine for h	5
virus titers in supernatants	5
were considered to be	5
white powder was insoluble	5
atoms of the amino	5
is a powerful tool	5
was performed on a	5
were carried out in	5
evaluated against hepg cells	5
long period of time	5
highly potent and selective	5
as we have recently	5
plays a role in	5
are shown in green	5
in lysosomes and whole	5
distance of the center	5
to generate larger biscao	5
p s k signaling	5
at this position as	5
one of the active	5
and their applications in	5
has not yet been	5
water was sprayed onto	5
contents of four glucosinolates	5
the antiviral activity was	5
the anomeric proton of	5
in the human diet	5
of the ligand are	5
inhibition of herpes simplex	5
examples of the successful	5
of wild hemp from	5
zooms into the region	5
single letter residue code	5
table gives the symbol	5
viruses of distinct phylogenetic	5
it is interesting to	5
extraction of bioactive compounds	5
c h n o	5
activities of biscao water	5
in the area of	5
a measure of the	5
understanding the molecular mechanisms	5
residue code along with	5
of the center of	5
aniline in the presence	5
reported in the case	5
skov ovarian cancer cells	5
hydrogen bonds with the	5
the drug discovery process	5
the highest bioactivity against	5
with a variety of	5
an interaction between ca	5
transient covalent bond with	5
the case of compounds	5
be involved in the	5
potency and selectivity for	5
the region containing the	5
by the fact that	5
over other tested cysteine	5
emodin derivatives linked with	5
in the innate immune	5
supernatant of a suspension	5
of inflammatory cytokines and	5
merck silica gel f	5
is consistent with the	5
was analyzed from t	5
binding site of a	5
simplex virus type glycoprotein	5
were preferred at this	5
maximum potency and selectivity	5
of transcription and replication	5
have been employed to	5
achieve the formation of	5
to that of the	5
property exerted the maximum	5
to be the most	5
the design of the	5
has been improved by	5
cells in vitro by	5
are displayed using yellow	5
the presence of et	5
aqueous solution of paracetamol	5
was estimated to be	5
along with their position	5
of the results obtained	5
sar analysis of this	5
one compound qbsc d	5
be explained by the	5
on the template surface	5
the results indicate that	5
inhibitory effect on the	5
the treatment of influenza	5
molarity ratio and additional	5
as well as a	5
a flow rate of	5
c in a co	5
significance was analyzed from	5
the antioxidant properties of	5
added to the cells	5
of the tested compounds	5
this is in agreement	5
are a class of	5
the in vitro anti	5
set of technical replicates	5
in the control of	5
have the potential to	5
a class of flavonoids	5
that the antiviral activity	5
of the benzodiazepine inhibitors	5
which correspond to the	5
the obtained results are	5
in a more recent	5
with tmprss during ns	5
on the nature of	5
the treatment of viral	5
and are able to	5
an effective way to	5
dpph radical scavenging and	5
ala val leu phe	5
capacity of a substance	5
concentration of cbd in	5
the phage display community	5
inactivation exhibited the following	5
of biscao water on	5
in the reacting system	5
example of this is	5
are shown in cyan	5
over anhydrous na so	5
and tumor necrosis factor	5
to unravel the molecular	5
selective over cathepsin b	5
the indole ring is	5
with methanolic ammonia provided	5
against influenza a virus	5
of the complement system	5
a dictionary of indian	5
apoptosis in hepg cells	5
ml of clean water	5
in human colon cancer	5
treatment of compound a	5
cfu ml of cf	5
a condensation reaction between	5
the binding domain to	5
binding site of the	5
dose of mg kg	5
interacting with the ligand	5
the efficacy and safety	5
to identify potential inhibitors	5
a large variety of	5
human respiratory syncytial virus	5
substituents at the para	5
materials can be accessed	5
this position as comparison	5
of a suspension of	5
be utilized to develop	5
commonly found in nature	5
catalyzed synthesis of phosphoramidates	5
reaction mixture was stirred	5
ccl in the presence	5
been found to possess	5
cysteine protease from t	5
by indian medicinal plants	5
was the most active	5
in human embryonic lung	5
in the lungs of	5
considered to be a	5
the potential use of	5
which is an important	5
have been demonstrated to	5
and colloidal dispersion exhibited	5
effect of rgdechi d	5
are given in table	5
water was prepared by	5
antioxidant activity of umifenovir	5
through the induction of	5
the design of a	5
while the carbon atoms	5
in vitro and ex	5
nitrogen atom of the	5
produced by indian medicinal	5
we have recently described	5
by an interaction between	5
for the prevention of	5
of influenza virus infection	5
of small molecule inhibitors	5
of india the wealth	5
the performance of the	5
procedure analogous to that	5
cells were pretreated with	5
as shown by the	5
interactions within the s	5
to achieve the formation	5
and in vitro evaluation	5
that none of the	5
their position in the	5
the present study was	5
exhibited the following trend	5
compounds of series ii	5
of this series was	5
for the discovery of	5
for sert and d	5
activation of the caspase	5
binding of the target	5
the influence of the	5
statistical analysis was performed	5
a more recent study	5
the death of cancer	5
nh group of the	5
considered as and the	5
raman spectrum of ac	5
these derivatives were prepared	5
significance is determined by	5
form hydrogen bonds with	5
the development of therapeutic	5
a set of mimotopes	5
with their position in	5
to the infected cells	5
to interfere with the	5
because of the different	5
the eos of wild	5
ligand d shape similarity	5
was injected into the	5
with the corresponding single	5
the innate immune response	5
based de novo design	5
the hcv protease and	5
did not show any	5
presence of et n	5
crucial role in the	5
on phytochemicals of indian	5
potent and selective inhibitors	5
a rat model of	5
to the cell surface	5
test compared with the	5
the powerful deshielding effect	5
the stage of transcription	5
this work was supported	5
added to ml of	5
characterization of a novel	5
the amount of il	5
cell migration and invasion	5
in the isoxazolidine ring	5
in agreement with those	5
in most of the	5
screening in drug discovery	5
it turned out that	5
top phytochemical inhibitors of	5
synthesis was explored with	5
different types of cancer	5
effect of silver nanoparticles	5
at the time of	5
substituents were preferred at	5
as a mixture with	5
bovine viral diarrhoea virus	5
in a wide variety	5
synthesis was explored using	5
from the center of	5
of the eos of	5
code along with their	5
for the reaction in	5
were used to evaluate	5
prepared by a procedure	5
has proven to be	5
with stirring for h	5
mentioned in this review	5
on the interaction between	5
into the region containing	5
in light of the	5
is consistent with our	5
domain to the spike	5
using h and c	5
and the production of	5
induction of autophagic cell	5
and autophagic cell death	5
required to reduce virus	5
generate larger biscao particles	5
of the effect of	5
which incur both hydrophobicity	5
generated by an interaction	5
patterning electrodes creating dielectric	5
cells were grown in	5
the column temperature was	5
synthesis of phosphoramidates using	5
in various types of	5
the development of vaccines	5
as and the remaining	5
can lead to the	5
cathepsin l over other	5
in prostate cancer cells	5
was isolated from the	5
gly ala val leu	5
the residue was purified	5
highest bioactivity against candida	5
wild hemp from austria	5
as a white solid	5
and their effects on	5
the cell membrane is	5
inactivated cathepsin l with	5
of dna aptamers against	5
after removal of the	5
yielded the target derivative	5
have already been established	5
breast cancer cell lines	5
were carried out at	5
inhibitors of human cathepsin	5
for c h n	5
hydroxyl group in was	5
washed twice with pbs	5
withdrawing property exerted the	5
the two magnesium ions	5
potentially be utilized to	5
and evaluation of their	5
targets for the development	5
luminescent cell viability assay	5
proposed mechanism for an	5
stage of transcription and	5
colorless and transparent with	5
dictionary of indian raw	5
the ple and pl	5
the authors did not	5
the supernatant of a	5
the results obtained from	5
used to calculate the	5
the growth of cancer	5
antiviral activity of the	5
has been widely described	5
found to be the	5
and the supernatant was	5
of aconitine alkaloids and	5
inhibits the growth of	5
dried over anhydrous na	5
drug analysis and screening	5
can be controlled by	5
virus into the host	5
in drug screening and	5
the biological functions of	5
corresponding single letter residue	5
has been used in	5
exposed surface of the	5
active sites of the	5
that this class of	5
the apoptosis of cancer	5
values of the inactivation	5
the sequence of the	5
desired product is formed	5
growth of cancer cells	5
of the inhibitor in	5
tmprss during ns to	5
more research is required	5
was followed by the	5
compared with the control	5
from a reaction of	5
other tested cysteine proteases	5
the last few decades	5
of the chemical shift	5
in combination with the	5
the replacement of the	5
transparent with a ph	5
de novo design of	5
a series of nitrile	5
amines such as aniline	5
was also used to	5
human gastric cancer cells	5
against fungus candida albicans	5
the fe o mgo	5
the phosphorylation of amines	5
peer review of the	5
of the natural compounds	5
was carried out by	5
assisted laser desorption ionization	5
groups present in t	5
against the main protease	5
was carried out using	5
is the work by	5
in the binding pocket	5
c h o by	5
carried out a thorough	5
at the s subsite	5
the synthesis of the	5
and selectivity for cathepsin	5
laser desorption ionization time	5
important to note that	5
of the known inhibitors	5
identification of potential inhibitors	5
and other constituents from	5
treated with different concentrations	5
without the need of	5
potential phytochemical inhibitors of	5
in a humidified atmosphere	5
formation of an extensive	5
configurations of isoxazolidines cis	5
epa or ht alone	5
can interact with other	5
have been identified in	5
reverse transcriptase inhibitory activity	5
the ligand atoms via	5
a was reduced with	5
synthesized using the iodine	5
to the reference drug	5
nucleophilic substitution between the	5
drug design and discovery	5
of one of the	5
be one of the	5
the us food and	5
india the wealth of	5
causing the death of	5
the s subsite of	5
of the viral envelope	5
indian raw materials industrial	5
in the final step	5
antioxidant capacity of a	5
to the progression of	5
the active site cleft	5
and incubated for h	5
of wild hemp buro	5
are important for the	5
afford the desired product	5
hq and its derivatives	5
a bruker avance iii	5
the authors developed a	5
in table and figure	5
to be required for	5
of the intensity of	5
of biscao and bisca	5
activation of the nlrp	5
in the protein sequence	5
were more potent than	5
vitro and ex vivo	5
on the interaction of	5
aptamers have been selected	5
wealth of india the	5
as an internal standard	5
the compound concentration required	5
and concentrated under reduced	5
the fight against cancer	5
were infected with zikv	5
in order to be	5
to the spike receptor	5
prone to the formation	5
the search of novel	5
the amine to give	5
bind to the target	5
the causative agent of	5
statistical significance is determined	5
following trend for aa	5
identify potential inhibitors of	5
can be combined with	5
of biscao water and	5
h of stirring in	5
of amino acid sequences	5
opens the door for	5
it is well established	5
ability to inhibit the	5
the inhibitory activity of	5
quaternary ammonium salt derivatives	5
fold selective over cathepsin	5
showed that biscao water	5
of respiratory syncytial virus	5
incur both hydrophobicity and	5
a major constituent of	5
most of the compounds	5
are labelled with the	5
mixture was stirred at	5
were used in the	5
of the gp protein	5
that bind to the	5
aerial parts of cimicifuga	5
the cellular uptake of	5
green colour while the	5
to be active against	5
spectra were recorded at	5
of the inactivation exhibited	5
was defined as the	5
the effect of rgdechi	5
were present in the	5
c and h in	5
healing of pseudomonas aeruginosa	5
shown in cyan colour	5
of ac in the	5
enzyme linked immunosorbent assay	5
reported to be a	5
by direct methods and	5
had the highest bioactivity	5
antiplasmodial activity using cell	5
compound in the usa	5
in human breast cancer	5
synthetic routes to p	5
an ec value of	5
the exposed surface of	5
and incubated at room	5
on the phenyl ring	5
is important to note	5
were incubated for h	5
spontaneous hemp from hungary	5
compared with the zikv	5
atoms of the ligand	5
the lloq in the	5
the antiviral activities of	5
of the homology model	5
better understanding of the	5
is dependent on the	5
tmprss or cathepsin l	5
ic value of nm	5
an intensity increase of	5
coli topoisomerase i and	5
melting points were determined	5
agents such as ccl	5
removed in vacuo and	5
the selected natural compounds	5
the amount of active	5
is likely to be	5
of pi k akt	5
the efficacy of the	5
and the substrate binding	5
as a set of	5
for their antiviral activities	5
a procedure analogous to	5
analogous to that described	5
lloq in the current	5
via hydrogen bonds or	5
the most widely used	5
both lb and sb	5
in the management of	5
sert and d receptor	5
binding domain to the	5
figure zooms into the	5
as the ratio of	5
is the number of	5
position as comparison of	5
the viral life cycle	5
its antiplasmodial activity using	5
powerful deshielding effect of	5
the back skin of	5
phosphorylation of p mapk	5
time of addition assay	5
of the aconitine alkaloids	5
of formyl peptide receptor	5
it is possible that	5
due to the formation	5
were evaluated for their	5
and pharmacological evaluation of	5
to be a promising	5
and transparent with a	5
inhibit the replication of	5
key role in the	5
the gene expression of	5
the bioactivity of the	5
of binding to the	5
the active component of	5
virus type glycoprotein h	5
means that the presence	5
optimal number of components	5
the rate constants of	5
has led to the	5
alone or in combination	5
the lipophilicity of the	5
at the concentration of	5
raw materials industrial products	5
can be accessed at	5
at the exposed surface	5
l over other tested	5
the virucidal activity of	5
the further development of	5
ligand are shown in	5
region containing the catalytic	5
with the ligand atoms	5
of the isoxazolidine ring	5
the maximum potency and	5
the release of cytochrome	5
a nucleophilic substitution between	5
in order to generate	5
or in combination with	5
ml of biscao water	5
spectra of ac interacted	5
example is the work	5
the figure zooms into	5
probably due to the	5
inhibiting the growth of	5
a time of addition	5
was used to determine	5
may be due to	5
a have already been	5
for simultaneous detection of	5
with the bidentate ligand	5
both hydrophobicity and electron	5
emodin quaternary ammonium salt	5
smooth metal or plastic	5
the basis of the	5
through inhibition of the	5
by means of the	5
a tetrahedral coordination of	5
with the zikv group	5
labelled with the corresponding	5
over cathepsin b and	5
the molecular basis of	5
active site cleft of	5
the formation of phosphoramidates	5
per sample was determined	5
when biscao water was	5
tc and cf were	5
the administration of epa	5
of tmprss in complex	5
the enhancement factor of	5
in green colour while	5
the eo of spontaneous	5
the genome sequence of	5
mode of action of	5
is a member of	5
mechanism for the iodine	5
a suspension of this	5
prepared compounds were screened	5
that can be found	5
was performed using the	5
of the human immunodeficiency	5
by a procedure analogous	5
supplementary materials can be	5
the results from this	5
were also obtained with	4
combination of lb and	4
direct methods and refined	4
characteristics of heated scallop	4
the extraction of bioactive	4
by the authors in	4
studies were carried out	4
cells based on the	4
is also important to	4
and structural elucidation of	4
well as for the	4
in the expression of	4
is necessary for the	4
quercetin has been approved	4
resolved by direct methods	4
type ia topoisomerases have	4
docked pose of screened	4
inhibition of hepatitis c	4
using a handheld odor	4
to the side chain	4
did not exhibit any	4
internal ribosome entry site	4
detection of active cathepsin	4
that selectively detected cathepsin	4
to the carbon and	4
dimensional model of the	4
associated with severe acute	4
the binding affinity and	4
the structure of qbsc	4
interactions and conformational strain	4
probes enabled the detection	4
isolated compounds and fractions	4
ns have been found	4
novel coronavirus associated with	4
membrane of the target	4
temperature was maintained at	4
plays a crucial role	4
each well of a	4
the target to the	4
amounts of stoichiometric waste	4
the authors postulated that	4
have focused on the	4
evaluated in ewat of	4
inhibitors of tmprss namely	4
was then subjected to	4
interactions compensated for higher	4
mechanism of action and	4
product was purified on	4
as expected that lps	4
the first step from	4
activity of human top	4
a greater inhibitory effect	4
two active forms of	4
during the life cycle	4
dispersion contained insoluble cao	4
changes of overall therapeutic	4
conversion of diethyl hydrogen	4
of this study was	4
coil around the surface	4
of the pyrazole derivatives	4
ki ki values of	4
compound a suppressed the	4
and d nmr experiments	4
of the virus was	4
ethanol to the known	4
contained insoluble cao and	4
enabled the detection of	4
inhibitory effect of mizoribine	4
death of cancer cells	4
the progression of skov	4
quantitative estimate of drug	4
the early steps of	4
intracellular inactive precursors of	4
on the docking binding	4
the interaction of cationic	4
main protease of the	4
incubation of cellular extracts	4
the primary stage of	4
b over cathepsin s	4
of a large number	4
by other papers for	4
selectively detected cathepsin l	4
prevention and treatment of	4
a series of novel	4
activity of cathepsin l	4
molecular interactions with the	4
the majority of the	4
with i to form	4
which is colorless and	4
the nmr spectra were	4
is considered to be	4
raman spectra of ac	4
lily bulb trypsin inhibitor	4
ir spectra of ac	4
protons were observed in	4
counting were performed as	4
formula of was established	4
a comprehensive review on	4
the most commonly used	4
has been reported as	4
presence of two protein	4
the nucleophilic substitution of	4
phenylphosphoramidate complex with an	4
rmsd and rmsf values	4
of chinese herbal medicine	4
the affinity of the	4
fe o mgo nanoparticles	4
cell culture supernatant when	4
curve from zero to	4
compared to the benzofuranyl	4
was selected as the	4
could be potentially be	4
been observed that the	4
followed by the addition	4
plates were incubated at	4
at the s site	4
deep eutectic solvents for	4
evaporation followed by reconstitution	4
cancer cells and decreased	4
compounds and showed significant	4
as a negative control	4
are of similar geometry	4
cathepsin b was also	4
the most active compounds	4
studies have demonstrated that	4
to the concentration of	4
missing in the spectra	4
a lung cancer cells	4
in insulin secretory granule	4
made in triplicate and	4
proliferation of gastric cancer	4
by increasing the electron	4
are crucial for the	4
compound successfully probed the	4
this means that the	4
against the h n	4
from zero to infinity	4
type ia topoisomerases can	4
african green monkey kidney	4
of the formation of	4
chemical shift values of	4
the basis of h	4
the treatment of type	4
peptide agonist for fpr	4
topoisomerase i and reverse	4
activity against enveloped viruses	4
ki values of the	4
obstructs the progression of	4
japanese encephalitis reporter virus	4
electron transfer oxidation of	4
the predicted r of	4
was resolved by direct	4
to the valporic acid	4
a number of n	4
dpph radical scavenging activity	4
of molecular similarity and	4
b and c are	4
reduced the relaxation activity	4
kcal mol for the	4
the inhibitory properties of	4
which then reacts with	4
of the identified phytochemical	4
progress has been made	4
as compared with the	4
two unknown proteins also	4
developed compound successfully probed	4
a thorough sar analysis	4
crude was purified by	4
critical role in cancer	4
also been used as	4
cells were used as	4
carbon and nitrogen atoms	4
involves covalent modification of	4
determine the antiviral activity	4
at the molecular level	4
a series of new	4
of h o and	4
the activity of the	4
the expression of pro	4
is positively influenced by	4
based on our previous	4
eos and their components	4
a high concentration of	4
biological evaluation of novel	4
had no role in	4
vacuum evaporation followed by	4
presence and absence of	4
of our studies on	4
candidates for the treatment	4
internalization of the virus	4
types of cancer treatments	4
the nlrp inflammasome was	4
water was exposed to	4
for tmprss and cathepsin	4
of active cathepsin l	4
lps and atp treatment	4
and at the same	4
with the aim to	4
of cellular extracts with	4
and the crude product	4
the estimated binding energy	4
in the supernatant was	4
to be higher than	4
then subjected to a	4
mechanism of the i	4
for targeted drug delivery	4
of the desired product	4
with sodium borohydride in	4
the release of pro	4
r h and r	4
compound was obtained as	4
assays were performed in	4
back skin of hairless	4
in the scientific literature	4
using signal amplification by	4
ppm due to the	4
the extract of ypf	4
benzofuranyl and imidazopyridinyl ligands	4
highest binding energy of	4
the hmbc correlation of	4
of rna molecules that	4
this process was repeated	4
based on the docking	4
and have great potential	4
estimated binding energy of	4
this scaffold showed improved	4
diameters of inhibition zones	4
after the treatment of	4
for a variety of	4
application of dna aptamers	4
in continuation of our	4
marginal selectivity over cathepsin	4
covalent modification of the	4
comparative with the free	4
in the heart tissue	4
the complexity of the	4
images of biscao water	4
shows a tetrahedral coordination	4
as a final remark	4
the lower limit of	4
and b in kirsten	4
at different concentrations for	4
against human immunodeficiency virus	4
reduce the cell proliferation	4
are not able to	4