bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
acute respiratory	911
respiratory syndrome	728
severe acute	710
severe covid	539
mg kg	363
clinical signs	348
liver failure	345
respiratory distress	289
novel coronavirus	287
coronavirus disease	273
intensive care	253
severe hepatitis	246
mechanical ventilation	241
syndrome coronavirus	236
critically ill	230
risk factors	220
immune response	211
severe cases	206
respiratory failure	203
falciparum malaria	200
severe disease	186
distress syndrome	186
severe malaria	182
rights reserved	169
hepatic encephalopathy	160
septic shock	160
sars coronavirus	155
renal failure	153
clinical characteristics	151
severe pneumonia	147
ill patients	140
care unit	138
systematic review	136
clinical trials	136
ml kg	133
liver disease	132
kg iv	131
clinical features	129
disease severity	128
inflammatory response	127
immune responses	123
sars patients	123
respiratory tract	120
cytokine storm	117
hospitalized patients	116
viral load	114
blood pressure	113
type i	113
may also	112
inflammatory cytokines	111
immune system	111
innate immune	111
convalescent plasma	110
cerebral malaria	108
lung injury	107
cohort study	106
epithelial cells	105
world health	103
severe sepsis	103
severe group	98
severe patients	97
peripheral blood	97
mortality rate	96
hong kong	96
chronic liver	95
clinical manifestations	95
severe respiratory	95
health organization	94
clinical trial	94
metabolic acidosis	92
spike protein	92
severe cap	92
public health	90
acquired pneumonia	90
liver transplantation	89
viral infections	88
severe asthma	87
increased risk	85
respiratory disease	84
coronavirus infection	83
converting enzyme	82
organ failure	80
author funder	80
orogastric lavage	80
significantly higher	80
granted medrxiv	79
cord uid	79
doc id	79
infectious diseases	78
virus infection	78
pulmonary edema	77
severe illness	77
activated charcoal	77
viral infection	76
united states	76
blood flow	76
risk factor	75
side effects	75
liver function	72
cov infection	71
infected patients	71
mental health	70
abdominal pain	70
acute liver	70
supplemental oxygen	70
chronic hepatitis	69
pediatric patients	68
intravenous fluids	68
may occur	67
patients infected	67
arterial blood	67
clinical course	66
viral replication	66
peer review	66
controlled trial	66
nervous system	66
nitric oxide	66
middle east	65
respiratory rate	65
kg po	62
fda labels	62
chest ct	62
reactive protein	62
nk cells	61
cardiac output	61
severe falciparum	61
two groups	61
copyright holder	61
heart failure	60
clinical practice	60
severe ea	60
east respiratory	60
disseminated intravascular	59
binding lectin	59
severe critical	59
airway obstruction	59
important role	59
patients treated	58
retrospective cohort	58
intravascular coagulation	58
lactate dehydrogenase	58
high risk	58
lopinavir ritonavir	58
bone marrow	57
health care	57
plasmodium falciparum	57
monoclonal antibody	57
lung function	57
hbv infection	57
adult patients	57
heart rate	57
liver cirrhosis	56
logistic regression	56
critical care	56
necrosis factor	56
hepatorenal syndrome	55
acute lung	55
randomized controlled	54
mg dl	54
patients may	54
sars cov	54
version posted	54
organ dysfunction	54
multiple organ	53
poor prognosis	53
portal hypertension	53
asthma exacerbations	53
icu admission	53
liver diseases	53
clinical symptoms	53
see section	53
liver injury	53
higher risk	52
infectious disease	52
pulmonary vascular	52
lymphocyte count	51
adaptive immune	51
red blood	51
young children	51
endothelial cells	50
upper respiratory	50
prospective study	50
blood cells	50
viral rna	49
cell responses	49
early stage	49
retrospective study	49
platelet count	49
immune cells	49
case series	49
gastrointestinal tract	49
randomized clinical	48
critical patients	48
innate immunity	48
incubation period	48
respiratory viruses	48
central nervous	48
pleural effusion	48
coronavirus pneumonia	47
fluid therapy	47
renal function	47
physical examination	47
induce emesis	47
animal models	47
high levels	47
liver cells	47
pregnant women	47
assessment report	46
cytokine release	46
high mortality	46
clinical data	46
factors associated	46
gastrointestinal bleeding	46
adverse effects	46
among patients	46
reuse allowed	45
bacterial infection	45
allowed without	45
systemic inflammatory	45
prothrombin time	45
without permission	45
present study	44
perform orogastric	44
tumor necrosis	44
heart disease	44
observational study	44
severe fever	44
mm hg	43
acute renal	43
thrombocytopenia syndrome	43
hepatic failure	43
severely ill	43
acute phase	43
body weight	43
associated coronavirus	43
patients admitted	43
early diagnosis	42
determine whether	42
pulmonary disease	42
administer intravenous	42
within hours	42
critical illness	42
whenever possible	42
crystalloid fluids	42
central venous	42
significant difference	41
patients receiving	41
host immune	41
accepted article	41
urine output	41
case report	41
kg hour	41
statistically significant	41
blood cell	40
complement activation	40
carbon dioxide	40
foreign bodies	40
respiratory symptoms	40
lower respiratory	40
equine asthma	40
inflammatory responses	39
metabolic alkalosis	39
severe liver	39
influenza virus	39
spectrum antibiotics	39
rheumatoid arthritis	39
lung disease	39
whole blood	39
another study	39
acute exacerbation	39
staphylococcus aureus	39
closely related	39
previous studies	39
ill covid	39
cerebral edema	39
coagulation factors	39
release syndrome	38
dendritic cells	38
new coronavirus	38
systemic inflammation	38
airway inflammation	38
liver cell	38
blood glucose	38
intracranial pressure	38
inflammatory cytokine	38
neutralizing antibodies	38
may cause	38
proinflammatory cytokines	38
ace expression	37
disease progression	37
kg minute	37
body temperature	37
significant differences	37
neutralizing antibody	36
many cases	36
blood vessels	36
bronchoalveolar lavage	36
independent risk	36
serum levels	36
recent study	36
antibody responses	36
endothelial cell	36
macrophage activation	36
airway disease	36
large number	36
critical covid	35
blood gas	35
first hours	35
oxygen saturation	35
patients showed	35
develop severe	35
clinical outcomes	35
pulmonary hypertension	35
white blood	35
urinary tract	34
clinical management	34
clinical studies	34
critical cases	34
patients without	34
social isolation	34
may develop	34
medrxiv preprint	34
hospital mortality	34
fungal infection	34
nucleic acid	34
foreign body	34
inflammatory reaction	34
severe infection	34
supportive care	33
intravenous crystalloid	33
significantly increased	33
natural killer	33
intravenous immunoglobulin	33
controlled trials	33
pulse oximetry	33
significantly lower	33
posted may	33
severe community	33
tract infection	33
case reports	33
antiviral drugs	33
frozen plasma	33
pulmonary embolism	33
i ifn	33
disease control	33
tidal volume	33
poor outcome	32
cell count	32
adverse events	32
care workers	32
maternal morbidity	32
drotrecogin alfa	32
mortality rates	32
cause severe	32
fatality rate	32
icu patients	32
several studies	32
may result	32
may lead	32
kg day	32
endotracheal intubation	31
intravenous fluid	31
inflammatory mediators	31
fresh frozen	31
infected pneumonia	31
chain reaction	31
pandemic influenza	31
general anesthesia	31
bacterial infections	31
survival rate	31
plasminogen activator	31
type hepatitis	31
hospital admission	31
also found	31
clinical improvement	31
one study	31
activation syndrome	31
diabetes mellitus	30
diagnostic criteria	30
limited settings	30
treatment consists	30
pediatric intensive	30
hepatitis patients	30
response syndrome	30
also reported	30
invasive mechanical	30
obstructive pulmonary	30
one patient	30
african children	30
included studies	30
immunomodulatory therapy	30
elevated levels	30
emergency care	30
serum albumin	30
hemophagocytic lymphohistiocytosis	29
soft tissue	29
regression analysis	29
respiratory syncytial	29
commonly used	29
severe dengue	29
cytokine levels	29
blood samples	29
complement system	29
cardiovascular disease	29
gene expression	29
plasma therapy	29
nk cell	29
within days	29
underlying disease	29
oxygen therapy	29
early phase	29
clinical presentation	29
differential diagnosis	29
liver damage	28
mild cases	28
control group	28
cytokine production	28
chronic obstructive	28
respiratory infections	28
avian influenza	28
lymphocyte ratio	28
intravenous catheter	28
i interferon	28
years old	28
oxygen delivery	28
prognostic factors	28
syncytial virus	28
diagnostic tests	28
scoring system	28
mechanically ventilated	28
pidd patients	28
severe maternal	28
kupffer cells	28
healthy controls	28
human coronavirus	27
care units	27
femoral head	27
underlying diseases	27
coronavirus associated	27
kawasaki disease	27
case fatality	27
polymerase chain	27
monoclonal antibodies	27
early stages	27
viral shedding	27
severe leukopenia	27
confirmed cases	27
clotting factors	27
blood ammonia	27
partial pressure	27
severe rd	27
serum creatinine	27
higher levels	27
significantly associated	27
patients hospitalized	27
respiratory alkalosis	26
sterile saline	26
gas exchange	26
hepatic cirrhosis	26
may contribute	26
mean age	26
blood volume	26
may require	26
th cells	26
may include	26
apache ii	26
increased levels	26
systemic circulation	26
cardiac dysrhythmias	26
extracellular traps	26
effective treatment	26
brain edema	26
mild covid	26
recurrent airway	26
make sure	26
amino acid	26
immune function	26
viral hepatitis	26
human coronaviruses	26
international license	26
endemic areas	25
molecular weight	25
viral clearance	25
viral entry	25
respiratory system	25
severe infections	25
currently available	25
two patients	25
upper airway	25
randomized trial	25
made available	25
sample size	25
laboratory tests	25
intestinal epithelial	25
saline solution	25
long term	25
iv cri	25
hpa axis	25
vitro studies	25
aspiration pneumonia	25
statistical analysis	25
syndrome virus	25
data suggest	25
cerebrospinal fluid	25
type ii	25
high fever	25
urinary catheter	25
rhesus macaques	25
local anesthetic	25
within weeks	25
neutrophil extracellular	25
disease caused	25
median age	25
alveolar damage	25
many patients	25
care medicine	25
hospitalized covid	24
receptor antagonist	24
fatal cases	24
gastrointestinal symptoms	24
coronavirus spike	24
moderate ea	24
cell types	24
amino acids	24
neurological diseases	24
may play	24
smooth muscle	24
protective immunity	24
computed tomography	24
lymph nodes	24
renal perfusion	24
endotracheal tube	24
fluid resuscitation	24
cardiac arrest	24
streptococcus pneumoniae	24
spike glycoprotein	23
signs associated	23
diaphragmatic hernia	23
angiotensin ii	23
host cells	23
antibiotic therapy	23
thoracic radiographs	23
therapy may	23
cardiac surgery	23
underlying cause	23
pulmonary interstitial	23
clinical outcome	23
maintain hydration	23
clinical severity	23
lung pathology	23
negative bacteria	23
shock syndrome	23
kidney disease	23
electrolyte abnormalities	23
blood count	23
laboratory findings	23
viral particles	23
ill children	23
growth factor	23
medical records	23
small number	23
children patients	23
retrospective analysis	23
small intestine	23
receptor binding	22
recent years	22
brain barrier	22
ventricular dysrhythmias	22
anterior chamber	22
aseptically scrub	22
within minutes	22
cell damage	22
lactic acidosis	22
ng ml	22
ml min	22
severe vs	22
viral loads	22
severe influenza	22
exchange transfusion	22
control study	22
confidence interval	22
oxidative stress	22
severe sars	22
infected cells	22
crystalloid fluid	22
cirrhotic patients	22
normal range	22
significantly different	22
blood products	22
emergency department	22
blood coagulation	22
fungal infections	22
cell entry	22
severe adenovirus	22
congestive heart	22
mild patients	22
emerging infectious	21
plasmodium vivax	21
ventilatory support	21
antiviral therapy	21
drug administration	21
body mass	21
host cell	21
pathological changes	21
hypersensitivity reactions	21
renal tubular	21
vascular resistance	21
tissue damage	21
angiotensin converting	21
vascular endothelial	21
vivax malaria	21
pulmonary function	21
cns excitation	21
general population	21
catheter placement	21
prognostic value	21
muscle tremors	21
multiple sclerosis	21
atopic dermatitis	21
climate change	21
odds ratio	21
like disease	21
vascular dilatation	21
acute hepatitis	21
functional receptor	21
also observed	21
wide range	21
lung damage	21
mucous membranes	21
cell response	21
positively correlated	21
stem cell	21
disease process	21
aspartate aminotransferase	20
pao fio	20
vaccine development	20
control seizures	20
inflammatory syndrome	20
factor viii	20
new york	20
developing severe	20
mean arterial	20
coagulation dysfunction	20
coronavirus infections	20
weight loss	20
common clinical	20
west nile	20
spinal cord	20
anaphylactic reactions	20
cell surface	20
combination therapy	20
moderate covid	20
kidney injury	20
refractory ascites	20
hepatopulmonary syndrome	20
small amount	20
urinary bladder	20
pneumonia group	20
high level	20
human monoclonal	20
toxicity include	20
also occur	20
kg sq	20
southern china	20
rna polymerase	20
multivariate analysis	20
ace receptors	20
high dose	20
class ii	20
sodium bicarbonate	20
bile duct	20
one case	20
even though	20
leukocyte count	20
virus infections	20
oral administration	20
first case	20
increased significantly	20
made based	20
infected individuals	20
fluid bolus	20
infection control	20
massive necrosis	20
liver dysfunction	20
head trauma	20
small intestinal	19
may reveal	19
capillary refill	19
gastroprotectant drugs	19
study showed	19
phase iii	19
analgesic drugs	19
ethylene glycol	19
study clinical	19
platelet transfusion	19
allergic reactions	19
may appear	19
study also	19
serum potassium	19
fulminant hepatitis	19
blood gases	19
protease inhibitors	19
may present	19
zika virus	19
reactive oxygen	19
dysfunction syndrome	19
adaptive immunity	19
remains unclear	19
broad spectrum	19
immunomodulatory therapies	19
nile virus	19
least one	19
ct scan	19
bridging necrosis	19
severe pulmonary	19
less severe	19
chest pain	19
disease onset	19
protease inhibitor	19
drug manual	19
lower airway	19
airway pressure	19
like receptor	19
may increase	19
stage liver	19
respiratory illness	19
cap group	19
primary immunodeficiency	19
diffuse alveolar	19
nonsteroidal antiinflammatory	19
peritoneal dialysis	19
first week	19
refill time	19
adverse reactions	19
intravenous quinine	18
south korea	18
arterial oxygen	18
blood transfusion	18
ventricular tachycardia	18
acute onset	18
spectrum antiviral	18
severe lung	18
descriptive study	18
previously healthy	18
factor vii	18
liver biopsy	18
moderate cases	18
replacement therapy	18
laboratory parameters	18
day mortality	18
toxic potential	18
clinical diagnosis	18
clinical picture	18
upper airways	18
failure caused	18
complete blood	18
neurological symptoms	18
patients will	18
fatal outcome	18
antibody response	18
infection may	18
full text	18
mild ea	18
mouse model	18
susceptibility testing	18
lymphocyte counts	18
pilot study	18
ema assessment	18
congenital heart	18
organ damage	18
blood group	18
like receptors	18
corticosteroid therapy	18
also associated	18
kupffer cell	18
lavage fluid	18
elderly patients	18
better understanding	18
common causes	18
lactic acid	18
sars virus	18
nlrp inflammasome	18
pediatric covid	18
cell membrane	18
immunocompromised patients	18
recombinant human	18
might also	18
ace receptor	18
rna viruses	18
rate infusion	18
renal dysfunction	18
differential diagnoses	18
constant rate	18
jak inhibitors	18
clinical progression	18
disease course	18
sore throat	18
antiviral activity	18
binding protein	18
transmission dynamics	18
receptor ace	18
intercostal space	18
corticosteroid treatment	18
enteral feeding	17
intravenous artesunate	17
absolute lymphocyte	17
host defense	17
short term	17
clinical variables	17
birth weight	17
chronic severe	17
cns depression	17
much higher	17
see table	17
portal vein	17
electron microscopy	17
igg antibodies	17
febrile illness	17
virus disease	17
toxic dose	17
adult inpatients	17
serine protease	17
performed using	17
healthy adults	17
escherichia coli	17
intraocular pressure	17
fibrin degradation	17
cell culture	17
test results	17
host factors	17
important factor	17
complicated malaria	17
severe systemic	17
vein thrombosis	17
categorical variables	17
study conducted	17
catheter hub	17
may help	17
human transmission	17
acute kidney	17
high incidence	17
important roles	17
rna virus	17
mbl deficiency	17
informed consent	17
advanced age	17
lyme disease	17
hyperferritinemic syndrome	17
natural history	17
allergic diseases	17
asthma exacerbation	17
loading dose	17
high doses	17
small animal	17
class i	17
dengue shock	17
hypovolemic shock	17
healthcare workers	17
respiratory function	17
stem cells	17
vaccine candidates	17
oxygen species	17
treatment strategies	17
study group	17
animal model	17
protective role	17
china clinical	17
occur within	17
oncotic pressure	17
higher incidence	17
symptom onset	17
warm water	17
inflammatory airway	17
partial thromboplastin	17
sars cases	17
three patients	17
high frequency	17
relapsing fever	17
first days	16
cell carcinoma	16
affected area	16
two cases	16
cardiogenic shock	16
missing data	16
widely used	16
may reduce	16
authors declare	16
immune activation	16
reduce mortality	16
signs may	16
patients died	16
immunodeficiency virus	16
low levels	16
overall mortality	16
candida albicans	16
human airway	16
mitochondrial dysfunction	16
serum bilirubin	16
venous blood	16
atrial fibrillation	16
different clinical	16
recently published	16
membrane oxygenation	16
hiv infection	16
person transmission	16
intestinal mucosa	16
fluid diuresis	16
cardiac disease	16
renal disease	16
multiple organs	16
vascular access	16
nkt cells	16
seasonal influenza	16
primary cause	16
clinical findings	16
significant increase	16
bacterial translocation	16
tract infections	16
tap water	16
artificial liver	16
healthy individuals	16
patients developed	16
potential therapeutic	16
red cell	16
will help	16
metabolic disorders	16
predictive value	16
studies showed	16
fi brosis	16
cell counts	16
association study	16
type iii	16
specific antibody	16
national health	16
exclusion criteria	16
older age	16
future studies	16
life cycle	16
arterial pressure	16
immune evasion	16
pulmonary artery	16
antiinflammatory drugs	16
elevated lactate	16
standard treatment	16
cov spike	16
multivariate logistic	16
bacterial peritonitis	16
granulation tissue	16
poor outcomes	16
inflammatory diseases	16
failure patients	16
among children	16
united kingdom	16
direct contact	16
dynamic changes	16
antibody titers	16
creative commons	16
severe symptoms	16
emergency use	16
spotted fever	16
prognostic significance	16
alanine aminotransferase	16
prospective observational	15
abo blood	15
significantly reduced	15
protective effect	15
late stage	15
structural proteins	15
severe coronavirus	15
primary care	15
mortality among	15
include vomiting	15
ace protein	15
high viral	15
antimicrobial peptides	15
spontaneous bacterial	15
may become	15
mesenchymal stem	15
prism score	15
several days	15
parenteral nutrition	15
clinical benefit	15
base imbalance	15
every hours	15
airway epithelial	15
influenza pandemic	15
large amounts	15
severe type	15
human ace	15
use authorization	15
bolus therapy	15
systemic infection	15
global health	15
extension tubing	15
multisystem inflammatory	15
yellow fever	15
dependent rna	15
renal replacement	15
common symptoms	15
chronic lung	15
intravenous infusion	15
status epilepticus	15
binding domain	15
meq kg	15
reverse transcription	15
angiotensin system	15
secondary hlh	15
patients usually	15
hbv replication	15
autoimmune diseases	15
southeast asia	15
urea nitrogen	15
intestinal mucosal	15
severe anaemia	15
pcr assays	15
cell activation	15
upper gastrointestinal	15
serum sodium	15
interim guidance	15
treatment group	15
drug name	15
drug resistance	15
hemolytic anemia	15
infectious agents	15
posted march	15
higher mortality	15
activated partial	15
syndrome clinical	15
urgent need	15
mixed viral	15
secondary infections	15
causes severe	15
sars outbreak	15
cardiac injury	15
respiratory acidosis	15
abdominal cavity	15
cancer drug	15
common cause	15
biliary tract	15
secondary infection	15
cell death	15
mononuclear cells	15
ct data	15
acute severe	15
lymphocyte subsets	15
continuous variables	15
coagulation factor	15
inflammatory markers	15
capillary permeability	15
red cells	15
taking care	15
pressure ventilation	15
respiratory pattern	15
sputum samples	15
extracorporeal membrane	15
viral pneumonia	15
reported cases	15
pneumonia caused	15
functional exhaustion	15
human disease	15
increased mortality	15
administer supplemental	15
ventricular fibrillation	15
human infection	15
exact test	15
adults hospitalized	15
bacterial co	15
strongly associated	14
also known	14
stimulating factor	14
active ingredient	14
induced acute	14
inflammatory cells	14
clinical manifestation	14
total body	14
pediatric icu	14
ct images	14
studies demonstrated	14
childhood asthma	14
vaccine candidate	14
immune dysregulation	14
acute hepatic	14
successfully treated	14
human immunodeficiency	14
base balance	14
analysis showed	14
renal blood	14
respiratory infection	14
patients also	14
large amount	14
ct findings	14
anion gap	14
patients aged	14
inborn errors	14
macrophage responses	14
cd cd	14
burn injury	14
elevated serum	14
injection site	14
dna vaccine	14
emergency treatment	14
affected horses	14
filtration rate	14
total number	14
abdominal radiographs	14
community outbreak	14
wide association	14
chest radiograph	14
two different	14
less common	14
data collection	14
hospital discharge	14
administer gastroprotectant	14
human lung	14
plasma exchange	14
blood urea	14
ventilation may	14
paediatric intensive	14
treated patients	14
emerging infections	14
years ago	14
coagulation system	14
recovered patients	14
cellular immune	14
virus replication	14
term outcome	14
intrahepatic cholestasis	14
assisted ventilation	14
significant risk	14
th cytokine	14
immune cell	14
antiviral drug	14
genetic variants	14
necrotizing pneumonia	14
long time	14
inflammatory cell	14
therapeutic strategies	14
clinical significance	14
pattern recognition	14
recent studies	14
ear canal	14
dry cough	14
total bilirubin	14
multiorgan failure	14
social distancing	14
positive pressure	14
case management	14
control measures	14
kg body	14
immune complexes	14
independently associated	14
function tests	14
oxygen supplementation	14
respiratory secretions	14
chinese center	14
promoter region	14
function testing	14
malarial disease	14
tissue perfusion	14
developed severe	14
glomerular filtration	14
respiratory status	14
therapeutic efficacy	14
fluid volume	14
cirrhosis patients	14
chronic pain	14
cardiac failure	14
successful treatment	14
time rt	14
deep learning	14
clinical presentations	14
leukocytes ml	14
study using	14
coronavirus replication	14
eosinophilic asthma	14
lactate levels	14
ct scans	14
specific igg	14
study involving	14
premature infants	14
patient may	14
tumour necrosis	14
int csr	14
gestational age	14
activated protein	14
two studies	14
different stages	14
infusion reactions	14
future research	14
key role	14
critical progression	14
fresh whole	14
pulmonary consolidation	14
family members	13
cytokine profiles	13
innate lymphoid	13
good prognosis	13
human respiratory	13
patients often	13
albumin levels	13
gas analysis	13
clinical study	13
data analysis	13
brain tissue	13
cap patients	13
liver tissue	13
red rubber	13
tissue distribution	13
cellular immunity	13
saharan africa	13
wound healing	13
anaphylactic reaction	13
mean duration	13
varying degrees	13
supplementary table	13
membrane fusion	13
genome sequence	13
young adults	13
venous pressure	13
liver enzymes	13
poor performance	13
atypical pneumonia	13
primary infection	13
antiemetic drugs	13
fluid management	13
consensus statement	13
age group	13
adhesion molecule	13
deep vein	13
venous catheter	13
disease clinical	13
imported malaria	13
repeated doses	13
serological tests	13
kg im	13
disease patients	13
induced liver	13
patients diagnosed	13
animal patients	13
thoracostomy tube	13
intestinal flora	13
findings suggest	13
lung tissue	13
affected individuals	13
solid organ	13
coagulation parameters	13
weight heparin	13
mild rd	13
liver transplant	13
phase i	13
blood circulation	13
hospital stay	13
density shadows	13
core promoter	13
allergic disease	13
real time	13
year old	13
severe complications	13
sars infection	13
hps patients	13
secondary hemophagocytic	13
administer activated	13
transjugular intrahepatic	13
systemic levels	13
increased susceptibility	13
significant reduction	13
prospective cohort	13
uncomplicated malaria	13
highly pathogenic	13
clinical disease	13
phase trial	13
plasma levels	13
increased respiratory	13
osmotic pressure	13
organ transplantation	13
ml syringe	13
worse outcome	13
free radical	13
average age	13
older adults	13
intrahepatic portosystemic	13
crucial role	13
prowess trial	13
clinical specimens	13
cells may	13
inhaled corticosteroids	13
gauge needle	13
myocardial infarction	13
uncomplicated falciparum	13
times higher	13
tissue factor	13
included patients	13
killer cells	13
mortality due	13
laboratory diagnosis	13
infected mice	13
coronavirus rna	13
type patients	13
sars pathogenesis	13
clinical treatment	13
thromboplastin time	13
csr sars	13
chronic respiratory	13
intravascular hemolysis	13
sodium chloride	13
minimal hepatic	13
tissue plasminogen	13
within months	13
urethral obstruction	13
packed rbcs	13
severe outcomes	13
lung cancer	13
extremely severe	13
baseline characteristics	13
study found	13
transplant recipients	13
high prevalence	13
adult respiratory	13
antiviral treatment	13
vital signs	13
acute covid	13
near miss	13
different types	13
known antidote	13
high rate	13
host response	13
cell subsets	13
nutritional support	13
recovery phase	13
foreign object	13
relatively low	13
base status	13
severe manifestations	13
tidal volumes	13
fast respiratory	13
also cause	13
largely supportive	13
organ systems	13
previously described	12
critical role	12
pulmonary capillaries	12
asthmatic patients	12
kidney function	12
without severe	12
treating patients	12
disease may	12
pulmonary infiltrates	12
proinflammatory cytokine	12
treatment protocol	12
allergic asthma	12
per minute	12
cp therapy	12
involving patients	12
phase ii	12
uric acid	12
north america	12
hla class	12
confirmed covid	12
will need	12
veterinary medicine	12
aged years	12
laryngeal paralysis	12
morbid neurological	12
copy number	12
minute iv	12
small sample	12
creatine kinase	12
second week	12
intrapulmonary vascular	12
psoriatic arthritis	12
several factors	12
several limitations	12
atrioventricular block	12
serum il	12
eosinophil counts	12
related coronavirus	12
serious complications	12
spider nevus	12
body surface	12
oxygen requirement	12
multicenter study	12
severe equine	12
task force	12
small amounts	12
preliminary report	12
study population	12
human mab	12
compassionate use	12
patient discomfort	12
seven days	12
glucocorticoid therapy	12
standard deviation	12
might lead	12
dimer levels	12
ebola virus	12
treatment guidelines	12
antithrombin iii	12
significant correlation	12
pneumonia outbreak	12
controlled study	12
short period	12
mass index	12
cardiovascular system	12
cytokine responses	12
median duration	12
convalescent sera	12
confirmed sars	12
target cells	12
contact tracing	12
time pcr	12
thrombotic complications	12
initial treatment	12
immune compromised	12
maternal mortality	12
elizabethan collar	12
early detection	12
bacterial sepsis	12
human cerebral	12
cohort studies	12
patients requiring	12
lower airways	12
balamuthia mandrillaris	12
ventilated patients	12
may provide	12
ii score	12
electronic medical	12
autoimmune disease	12
new virus	12
right atrium	12
also contribute	12
units kg	12
human body	12
storm syndrome	12
will provide	12
medical management	12
platelet counts	12
cell therapy	12
borrelia miyamotoi	12
hemorrhagic fever	12
viral proteins	12
von willebrand	12
first line	12
epithelial cell	12
stimulated gene	12
virus transmission	12
competing interests	12
surgical intervention	12
low molecular	12
chronic kidney	12
often associated	12
specific antibodies	12
impaired consciousness	12
health emergency	12
study reported	12
brain injury	12
minimum database	12
clipped area	12
antiviral effects	12
dermal exposure	12
non critical	12
cases may	12
icu syndrome	12
community acquired	12
life support	12
cell epitopes	12
interferon response	12
initial symptom	12
risk patients	12
tracheal mucus	12
valentine leukocidin	12
host responses	12
toxic effects	12
high rates	12
ventilation blood	12
high morbidity	12
lower levels	12
fio ratio	12
commercially available	12
type inflammation	12
atrial standstill	12
gene promoter	12
myocardial injury	12
primary disease	12
cell immunity	12
gold standard	12
human asthma	11
statistical significance	11
patient characteristics	11
mild disease	11
therapeutic option	11
depressive symptoms	11
cell dysfunction	11
will require	11
bronchial epithelial	11
accessory proteins	11
factor receptor	11
lung parenchyma	11
inflammatory drugs	11
mbl gene	11
critical group	11
pulmonary aspergillosis	11
rapid diagnosis	11
dependent enhancement	11
uncontrolled asthma	11
mg days	11
pulmonary arterial	11
fi rst	11
brain swelling	11
observational studies	11
electrolyte imbalance	11
clinical efficacy	11
colloid fluids	11
respiratory insufficiency	11
idiopathic arthritis	11
also lead	11
influenza viruses	11
pleural space	11
confluent necrosis	11
respiratory burst	11
severe stage	11
five days	11
main clinical	11
arterial partial	11
supplementary material	11
regular insulin	11
age groups	11
including sars	11
including severe	11
oxygen supply	11
small molecule	11
antiviral agent	11
molecular mechanisms	11
common patients	11
first step	11
cardiopulmonary arrest	11
contact layer	11
heartland virus	11
chronic renal	11
anesthetic drugs	11
mechanisms underlying	11
signal transduction	11
may reflect	11
ingestion includes	11
reperfusion injury	11
appropriate treatment	11
healthy children	11
symptoms may	11
working group	11
catheter site	11
hepatitis virus	11
influenza infection	11
nursing home	11
protein kinase	11
medical history	11
patchy shadows	11
primary liver	11
easily accessible	11
resource utilization	11
highly effective	11
mast cells	11
coagulation cascade	11
blood smear	11
respiratory covid	11
nosocomial infection	11
i interferons	11
affected animals	11
well tolerated	11
lymphoid cells	11
health checkup	11
predisposing factors	11
fatal covid	11
smoke inhalation	11
abnormal coagulation	11
nucleocapsid protein	11
janus kinase	11
platelet function	11
group i	11
asthma control	11
gastric decontamination	11
animals may	11
humoral immune	11
evidence suggests	11
toxic substances	11
outcomes among	11
sudden onset	11
may induce	11
decreased significantly	11
virus entry	11
reactions occurred	11
vena cava	11
bat origin	11
juvenile idiopathic	11
medical staff	11
endoplasmic reticulum	11
arterial hypertension	11
severe hepatic	11
water retention	11
abdominal ultrasound	11
results showed	11
developing countries	11
syndrome severe	11
will also	11
intravascular volume	11
open reading	11
side effect	11
continuous infusion	11
thoracic society	11
health outcomes	11
controlled clinical	11
immune dysfunction	11
bleeding tendency	11
treatment options	11
signs include	11
treatment strategy	11
domestic animals	11
healthy horses	11
inclusion criteria	11
genetic variation	11
subcutaneous emphysema	11
term management	11
serum biochemistry	11
patients compared	11
scoring systems	11
participants receiving	11
decompensated liver	11
rhesus macaque	11
four patients	11
skin lesions	11
respiratory viral	11
high blood	11
intestinal obstruction	11
therapeutic intervention	11
laboratory results	11
herpes simplex	11
dead space	11
drug interactions	11
pd deficiency	11
east asia	11
cooling measures	11
sepsis patients	11
oral transmission	11
bal fluid	11
pulmonary fibrosis	11
cell rna	11
situ hybridization	11
chronic hbv	11
causative agent	11
clinical research	11
pulmonary contusions	11
nasal discharge	11
readily available	11
requiring mechanical	11
major outbreak	11
animal studies	11
aggressive treatment	11
coagulation tests	11
cleavage site	11
factor xiii	11
respiratory diseases	11
low dose	11
glucose levels	11
plr value	11
million people	11
cytokine response	11
transgenic mice	11
respiratory support	11
skin rash	11
vast majority	10
temporary tracheostomy	10
clinically proven	10
current evidence	10
hepatocyte necrosis	10
recognition receptors	10
factors may	10
sequence analysis	10
ex vivo	10
organ perfusion	10
related reactions	10
important lessons	10
degradation products	10
often accompanied	10
esophageal irritation	10
maternal near	10
flapping tremor	10
international normalized	10
central role	10
intestinal tract	10
also may	10
gastrointestinal hemorrhage	10
therapeutic target	10
associated sars	10
blood culture	10
early warning	10
free water	10
severe anemia	10
specific treatment	10
significantly elevated	10
young covid	10
normalized ratio	10
laboratory testing	10
serum lactate	10
initial dose	10
probable sars	10
study design	10
mild moderate	10
guangdong province	10
platelet aggregation	10
cell infection	10
early recognition	10
immunoglobulin therapy	10
pg ml	10
induced illness	10
also important	10
patients survived	10
independent predictors	10
drugs used	10
univariate analysis	10
per se	10
tick bites	10
fluid loss	10
adult covid	10
coagulation disorders	10
stroke volume	10
postural changes	10
hbv carriers	10
pulmonary infection	10
may progress	10
serum sickness	10
respiratory samples	10
hbv quasispecies	10
accurate diagnosis	10
potential role	10
like protease	10
potent neutralization	10
systemic juvenile	10
potential risks	10
new insights	10
tissue injury	10
ascertainment rate	10
three days	10
intracranial hemorrhage	10
low tidal	10
acute sars	10
pulmonary oedema	10
ph value	10
patients presenting	10
high expression	10
radiological findings	10
preliminary data	10
circulating blood	10
malaria infection	10
neurological signs	10
mbl levels	10
clinically significant	10
probable bat	10
creatinine clearance	10
kg min	10
sectional study	10
severe thrombocytopenia	10
adenovirus infection	10
thromboembolic disease	10
natriuretic peptide	10
ill patient	10
peritoneal cavity	10
veterinary ophthalmologist	10
multiple testing	10
blood vessel	10
portosystemic shunt	10
nasopharyngeal aspirates	10
wuhan clinical	10
severe adverse	10
immunodeficient patients	10
tickborne infections	10
cell transplantation	10
convalescent patients	10
severe pandemic	10
antigen presentation	10
high concentrations	10
renal impairment	10
adenovirus pneumonia	10
cell deformability	10
sars pneumonia	10
blood clots	10
extracellular fluid	10
patients suffering	10
mice infected	10
septic patients	10
year prospective	10
tested positive	10
several weeks	10
iv slowly	10
signaling pathway	10
induced lung	10
willebrand factor	10
major role	10
specific symptoms	10
five cases	10
hbv dna	10
molecular biology	10
dose intravenous	10
allergic rhinitis	10
mean airway	10
rubber catheter	10
portal area	10
humanized mab	10
label non	10
hydrogen peroxide	10
clinical syndromes	10
small bowel	10
fluid balance	10
beneficial effects	10
invasive pulmonary	10
one year	10
severe inflammatory	10
lung inflammation	10
may influence	10
severe forms	10
altered mental	10
plasma inflammatory	10
physiological conditions	10
mental status	10
mg day	10
fluid overload	10
ballooning degeneration	10
oxygen inhalation	10
york city	10
blood tests	10
hypotensive shock	10
immunosorbent assay	10
severe hypoxemia	10
severe form	10
cancer patients	10
analyzed using	10
potential treatment	10
humoral responses	10
better understand	10
systolic blood	10
interquartile range	10
tracheal wash	10
spread rapidly	10
year period	10
sickle cell	10
data available	10
literature review	10
sporadic cases	10
west africa	10
global burden	10
randomised controlled	10
even death	10
factor xii	10
examination findings	10
oxygenation index	10
laboratory data	10
plasma concentration	10
syndrome patients	10
outbreak associated	10
early treatment	10
living alone	10
cardiovascular status	10
late stages	10
days post	10
viral diseases	10
preterm infants	10
symptomatic treatment	10
psychiatric disorders	10
publication bias	10
needle catheter	10
noncardiogenic pulmonary	10
likely due	10
abdominal distension	10
also showed	10
flow ratio	10
fracture site	10
reduced mortality	10
cell infiltration	10
short time	10
malignant progression	10
considered statistically	10
drug reactions	10
poor clinical	10
main causes	10
peritoneal lavage	10
respiratory droplets	10
saudi arabia	10
neurological manifestations	10
previous reports	10
observational cohort	10
mab used	10
clinical spectrum	10
common cold	10
lung lesions	10
energy metabolism	10
heparinized saline	10
systemic hypertension	10
pleural fluid	10
ill sars	10
one third	10
clinical conditions	10
bartonella infection	10
energy expenditure	10
environmental factors	10
psychiatric symptoms	10
antimicrobial therapy	10
practice guidelines	10
medical care	9
membrane protein	9
single center	9
cranial nerve	9
reverse transcriptase	9
include fever	9
plasmatic levels	9
placebo group	9
compared using	9
increased incidence	9
recently emerged	9
remains unknown	9
among women	9
two major	9
body fluid	9
pulmonary involvement	9
healthy donors	9
radiation therapy	9
factor alpha	9
vivax infection	9
cell apoptosis	9
airway epithelium	9
health status	9
early identification	9
two years	9
often cause	9
different degrees	9
less likely	9
left atrial	9
i iii	9
highly expressed	9
ct value	9
adult asthma	9
infection association	9
emergency management	9
also shown	9
clinical response	9
least two	9
six months	9
almost exclusively	9
commonly seen	9
increased capillary	9
white tape	9
mechanisms involved	9
anesthetic depth	9
main cause	9
immunocompromised hosts	9
motor neuron	9
sars epidemic	9
clinical sign	9
tracheal aspirates	9
rescue therapy	9
main protease	9
prophylactic anticoagulation	9
primary immunodeficiencies	9
confidence intervals	9
conventional mechanical	9
activator inhibitor	9
sterile gloves	9
clinical case	9
significant association	9
tidal carbon	9
treat covid	9
asymptomatic cases	9
calcium gluconate	9
arterial oxygenation	9
severe inflammation	9
two types	9
blood films	9
clot formation	9
protein levels	9
pneumonia patients	9
newborn infants	9
first described	9
related acute	9
recent meta	9
electrolyte imbalances	9
nonstructural protein	9
massive release	9
three types	9
viral activity	9
aspiration pneumonitis	9
ncov infection	9
myeloid cells	9
taken together	9
patients present	9
neurological sequelae	9
flow nasal	9
following conditions	9
moderate group	9
alveolar macrophages	9
hepatocellular carcinoma	9
hubei province	9
rib fractures	9
respiratory complications	9
prothrombin activity	9
longitudinal studies	9
improve outcomes	9
neutrophilic inflammation	9
granulomatous disease	9
adhesive tape	9
survival time	9
following formula	9
merkel cell	9
genomic characterisation	9
plasma concentrations	9
people living	9
serious adverse	9
intravenous injection	9
institutional review	9
lumbar puncture	9
require mechanical	9
health authorities	9
viral etiology	9
patients recovered	9
affected areas	9
severely affected	9
adverse drug	9
virus origins	9
unfractionated heparin	9
least days	9
international guidelines	9
intermediate layer	9
endemic regions	9
therapeutic effect	9
prognostic indicator	9
specific immune	9
naturally occurring	9
often occurs	9
infectious agent	9
traumatic brain	9
ideal body	9
significantly decreased	9
leading cause	9
vascular dilation	9
pathological features	9
acute abdominal	9
respiratory virus	9
progressive respiratory	9
guidance statement	9
also present	9
hbv related	9
active bleeding	9
published studies	9
chb patients	9
pulmonary inflammation	9
base excess	9
south america	9
sedimentation rate	9
consider cytokine	9
effect model	9
mycobacterium tuberculosis	9
lectin pathway	9
severe symptom	9
transitional cell	9
among others	9
sample collection	9
neutrophil count	9
one week	9
cardiac dysfunction	9
sodium concentration	9
tyrosine kinase	9
chronic health	9
cause clinical	9
mediated immunity	9
lateral recumbency	9
negative pressure	9
linked immunosorbent	9
inflammatory monocyte	9
medical therapy	9
following infection	9
fusion protein	9
renal insufficiency	9
body fluids	9
pleural cavity	9
patent airway	9
severe eosinophilic	9
secondary bacterial	9
clinical predictors	9
nuclear factor	9
prevent infection	9
case definitions	9
surgical correction	9
term use	9
clinical evidence	9
fda label	9
thermal burns	9
high affinity	9
children admitted	9
stranded rna	9
elevated il	9
way stopcock	9
retinal detachment	9
inspired oxygen	9
bacterial culture	9
commonly reported	9
positive results	9
cardiopulmonary bypass	9
inflammatory factors	9
acute malaria	9
three groups	9
adenovirus infections	9
associated encephalopathy	9
corona virus	9
also revealed	9
hepatic lobules	9
th th	9
following sars	9
fulminant liver	9
storm syndromes	9
like symptoms	9
particularly important	9
factors influencing	9
volume expansion	9
term prognosis	9
often difficult	9
new cases	9
human cases	9
routine clinical	9
immediate treatment	9
meld score	9
quantitative chest	9
low doses	9
aspergillus fumigatus	9
organ function	9
intrinsic renal	9
usually associated	9
common type	9
severe clinical	9
case study	9
may explain	9
antibody production	9
wbc count	9
medical treatment	9
pulmonary parenchymal	9
pneumonia severity	9
four factors	9
death rate	9
cardiovascular support	9
still remains	9
supraventricular tachycardia	9
structural protein	9
days following	9
structural basis	9
patients reported	9
immunol doi	9
aldosterone system	9
asymptomatic infection	9
tolerate oral	9
bal cytology	9
immune deficiency	9
diseases society	9
permissive hypercapnia	9
electrolyte status	9
occurred within	9
mannosebinding lectin	9
diagnostic peritoneal	9
bacterial pathogens	9
therapeutic approach	9
flow rate	9
muscle weakness	9
showed higher	9
barrier function	9
safety profile	9
intravenous extension	9
renal injury	9
cytokine profile	9
density lipoprotein	9
health system	9
dose corticosteroids	9
two independent	9
median survival	9
chronic rhinosinusitis	8
develop acute	8
important aspect	8
understanding sars	8
passive range	8
nipah virus	8
two doses	8
borrelia burgdorferi	8
hypersensitivity reaction	8
people worldwide	8
mannose binding	8
immune pathways	8
interferon responses	8
significant improvement	8
po bid	8
severe renal	8
function may	8
two weeks	8
randomised trial	8
review will	8
adverse outcomes	8
high serum	8
intravenous administration	8
aerosol inhalation	8
mucous membrane	8
will improve	8
treatment effects	8
patients show	8
severe bleeding	8
th cytokines	8
suspected cases	8
significant decrease	8
affected patients	8
multiple factors	8
cardiac contractility	8
disease pathogenesis	8
concentrated human	8
acute pulmonary	8
tissue necrosis	8
major cause	8
first day	8
neurologic examination	8
bilateral lung	8
may vary	8
pericardial effusion	8
imaging features	8
chronic bronchitis	8
respiratory pathogens	8
unclear whether	8
liver tissues	8
cell necrosis	8
proven protease	8
peripheral lymphocyte	8
lung diseases	8
term safety	8
airway remodelling	8
magnetic resonance	8
drug report	8
five patients	8
chronic hepatic	8
pulmonary angiography	8
th day	8
clinical care	8
vertical transmission	8
iv tid	8
insufficient ventilation	8
systematic reviews	8
sepsis campaign	8
time activity	8
amoy gardens	8
asthma phenotypes	8
gene polymorphisms	8
toxicity includes	8
first time	8
respiratory effort	8
improved survival	8
signaling pathways	8
exploratory laparotomy	8
increased viral	8
coronavirus sars	8
studies suggest	8
cerebral hernia	8
transfusion reaction	8
related liver	8
will increase	8
specific cd	8
human leptospirosis	8
biochemistry profile	8
supportive therapy	8
control groups	8
immunoglobulin products	8
blood sugar	8
room air	8
sodium phosphate	8
pneumonia groups	8
patient care	8
epidemiological characteristics	8
invasive aspergillosis	8
antimicrobial agents	8
less commonly	8
local anesthetics	8
medical emergency	8
ct imaging	8
first cases	8
incidence rate	8
clear evidence	8
candidate vaccines	8
serum amylase	8
commonly observed	8
ground glass	8
wearing sterile	8
human sars	8
predictive factors	8
humidified oxygen	8
nan doi	8
deceased patients	8
treat hyperthermia	8
cases among	8
commonly found	8
frequently used	8
operating characteristic	8
required mechanical	8
mouse models	8
myasthenia gravis	8
effective antiviral	8
acute intrinsic	8
may manifest	8
mild symptoms	8
play important	8
burst activity	8
also play	8
arterial thromboembolism	8
coronavirus pathogenesis	8
receiver operating	8
humoral response	8
aseptic necrosis	8
subcutaneous tissue	8
may take	8
well described	8
inhaled nitric	8
pit viper	8
persistent infection	8
progress rapidly	8
routine blood	8
absolutely contraindicated	8
adjunct therapy	8
blood smears	8
third day	8
one hand	8
different populations	8
bcg vaccination	8
cardiac silhouette	8
directed therapy	8
distal end	8
thoracic duct	8
hospitalization priority	8
patients following	8
previously shown	8
increased expression	8
primary outcome	8
potential benefits	8
available evidence	8
igg antibody	8
may benefit	8
fda drug	8
nasal catheter	8
hematopoietic stem	8
dna vaccines	8
hemorrhagic shock	8
derived macrophages	8
creactive protein	8
one month	8
vivo study	8
coronary heart	8
lung volume	8
face mask	8
review board	8
airway bleeding	8
older patients	8
opportunistic infections	8
expression levels	8
gastrointestinal ulceration	8
worse prognosis	8
blood ph	8
publisher full	8
lung involvement	8
kg ideal	8
cutaneous manifestations	8
ace gene	8
borne diseases	8
term outcomes	8
plr levels	8
recent review	8
adjunctive therapy	8
within normal	8
artificial ventilation	8
following criteria	8
specific conditions	8
refractory septic	8
upper limit	8
acute management	8
epidemiological studies	8
cytokine il	8
second intention	8
thoracic auscultation	8
rapid progression	8
entry depends	8
prerenal azotemia	8
cns disease	8
levels may	8
statistical difference	8
erythrocyte sedimentation	8
different groups	8
ongoing hemorrhage	8
prognostic factor	8
azole antifungals	8
bacterial meningitis	8
see also	8
interstitial pneumonia	8
large sample	8
much lower	8
endothelial growth	8
hour iv	8
infect dis	8
see sections	8
viral fusion	8
pcr testing	8
antiviral agents	8
normal blood	8
respiratory problems	8
pulmonary vasculature	8
carbon monoxide	8
blood type	8
like illness	8
preliminary study	8
receiving mg	8
often reveals	8
among cases	8
killer cell	8
fatality rates	8
progenitor cells	8
fluid deficit	8
plasma level	8
intoxication include	8
clinical evaluation	8
rna synthesis	8
underlying causes	8
abdominal paracentesis	8
viral disease	8
wound exudates	8
airborne transmission	8
intestinal endotoxemia	8
relatively high	8
international consensus	8
label use	8
viral pathogens	8
intermediate dose	8
severe patient	8
many factors	8
cov infections	8
improved clinical	8
respiratory compromise	8
hospitalised patients	8
line treatment	8
among adults	8
mortality associated	8
low risk	8
abdominal effusion	8
lymphocyte subset	8
perfusion parameters	8
jak inhibitor	8
nasopharyngeal swabs	8
circulating immune	8
patients required	8
endothelial dysfunction	8
patients received	8
clinical assessment	8
including il	8
tocilizumab treatment	8
survival rates	8
emerging viral	8
mortality risk	8
patients require	8
treat ingestion	8
small animals	8
available data	8
patients affected	8
cl pro	8
three times	8
failure may	8
based study	8
wide variety	8
generation cephalosporin	8
patients clinical	8
requiring intensive	8
mainland china	8
blood groups	8
infections may	8
intracranial hypertension	8
patients within	8
limited data	8
position paper	8
supportive treatment	8
hyaline membrane	8
promote diuresis	8
radiographs may	8
become infected	8
chloroquine hydroxychloroquine	8
nasal cpap	8
cumulative dose	8
chronic granulomatous	8
maintain renal	8
pseudomonas aeruginosa	8
surface area	8
eosinophilic inflammation	8
failure due	8
teaching hospital	8
current state	8
monitor urine	8
patient groups	8
dehydrogenase level	8
therapeutic options	8
previous study	8
viral protein	8